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Schizophrenia Research. Cognition

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https://www.readbyqxmd.com/read/29552509/effects-of-transcranial-direct-current-stimulation-on-working-memory-and-negative-symptoms-in-schizophrenia-a-phase-ii-randomized-sham-controlled-trial
#1
J S Gomes, A P Trevizol, D V Ducos, A Gadelha, B B Ortiz, A O Fonseca, H T Akiba, C C Azevedo, L S P Guimaraes, P Shiozawa, Q Cordeiro, A Lacerda, A M Dias
Background: The lack of efficacy of pharmacological treatments for cognitive and negative symptoms in schizophrenia highlights the need for new interventions. We investigated the effects of tDCS on working memory and negative symptoms in patients with schizophrenia. Method: Double-blinded, randomized, sham-controlled clinical trial, investigating the effects of 10 sessions of tDCS in schizophrenia subjects. Stimulation used 2 mA, for 20 min, with electrodes of 25 cm2 wrapped in cotton material soaked in saline solution...
June 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29552508/polygenic-signal-for-symptom-dimensions-and-cognitive-performance-in-patients-with-chronic-schizophrenia
#2
Rose Mary Xavier, Jennifer R Dungan, Richard S E Keefe, Allison Vorderstrasse
Genetic etiology of psychopathology symptoms and cognitive performance in schizophrenia is supported by candidate gene and polygenic risk score (PRS) association studies. Such associations are reported to be dependent on several factors - sample characteristics, illness phase, illness severity etc. We aimed to examine if schizophrenia PRS predicted psychopathology symptoms and cognitive performance in patients with chronic schizophrenia. We also examined if schizophrenia associated autosomal loci were associated with specific symptoms or cognitive domains...
June 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29552507/galantamine-memantine-combination-effective-in-dementia-translate-to-dementia-praecox
#3
Maju Mathew Koola, Ajay K Parsaik
No abstract text is available yet for this article.
June 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29527507/cognitive-and-psychopathology-correlates-of-brain-white-grey-matter-structure-in-severely-psychotic-schizophrenic-inpatients
#4
Nerisa Banaj, Federica Piras, Fabrizio Piras, Valentina Ciullo, Mariangela Iorio, Claudia Battaglia, Donatella Pantoli, Giuseppe Ducci, Gianfranco Spalletta
The brain structural correlates of cognitive and psychopathological symptoms within the active phase in severely psychotic schizophrenic inpatients have been rarely investigated. Twenty-eight inpatients with a DSM-5 diagnosis of Schizophrenia (SZ), admitted for acute psychotic decompensation, were assessed through a comprehensive neuropsychological and psychopathological battery. All patients underwent a high-resolution T1-weighted magnetic resonance imaging investigation. Increased psychotic severity was related to reduced grey matter volumes in the medial portion of the right superior frontal cortex, the superior orbitofrontal cortex bilaterally and to white matter volume reduction in the medial portion of the left superior frontal area...
June 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29159135/the-influence-of-schizotypal-traits-on-attention-under-high-perceptual-load
#5
Hanne Stotesbury, Sebastian B Gaigg, Saim Kirhan, Corinna Haenschel
Schizophrenia Spectrum Disorders (SSD) are known to be characterised by abnormalities in attentional processes, but there are inconsistencies in the literature that remain unresolved. This article considers whether perceptual resource limitations play a role in moderating attentional abnormalities in SSD. According to perceptual load theory, perceptual resource limitations can lead to attenuated or superior performance on dual-task paradigms depending on whether participants are required to process, or attempt to ignore, secondary stimuli...
March 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29159134/model-selection-and-prediction-of-outcomes-in-recent-onset-schizophrenia-patients-who-undergo-cognitive-training
#6
Ian S Ramsay, Sisi Ma, Melissa Fisher, Rachel L Loewy, J Daniel Ragland, Tara Niendam, Cameron S Carter, Sophia Vinogradov
Predicting treatment outcomes in psychiatric populations remains a challenge, but is increasingly important in the pursuit of personalized medicine. Patients with schizophrenia have deficits in cognition, and targeted cognitive training (TCT) of auditory processing and working memory has been shown to improve some of these impairments; but little is known about the baseline patient characteristics predictive of cognitive improvement. Here we use a model selection and regression approach called least absolute shrinkage and selection operator (LASSO) to examine predictors of cognitive improvement in response to TCT for patients with recent onset schizophrenia...
March 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29114452/using-virtual-reality-to-assess-theory-of-mind-subprocesses-and-error-types-in-early-and-chronic-schizophrenia
#7
Allana L Canty, David L Neumann, David H K Shum
Individuals with schizophrenia often demonstrate theory of mind (ToM) impairment relative to healthy adults. However, the exact nature of this impairment (first- vs. second-order ToM and cognitive vs. affective ToM) and the extent to which ToM abilities deteriorate with illness chronicity is unclear. Furthermore, little is known about the relationships between clinical symptoms and ToM error types (overmentalising, reduced mentalising and no ToM) in early and chronic schizophrenia. This study examined the nature and types of ToM impairment in individuals with early ( n  = 26) and chronic schizophrenia ( n  = 32) using a novel virtual reality task...
December 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28824850/feasibility-and-preliminary-efficacy-of-remotely-delivering-cognitive-training-to-people-with-schizophrenia-using-tablets
#8
Bruno Biagianti, Melissa Fisher, Lisa Howard, Abby Rowlands, Sophia Vinogradov, Joshua Woolley
BACKGROUND: Limited access to Cognitive Training (CT) for people with schizophrenia (SZ) prevents widespread adoption of this intervention. Delivering CT remotely via tablets may increase accessibility, improve scheduling flexibility, and diminish patient burden. METHODS: In this reanalysis of data from a larger trial of CT, we compared two samples of individuals with SZ who chose to complete 40 h of CT either on desktop computers in the laboratory ( N  = 33) or remotely via iPads ( N  = 41)...
December 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28824849/speed-and-capacity-of-working-memory-and-executive-function-in-schizophrenia-compared-to-unipolar-depression
#9
Wolfgang Trapp, Simone Dotterweich, Lena Hintner, Hannah Wollny, Stefan Lautenbacher, Göran Hajak
Schizophrenia is associated with deficits in working memory (WM) and executive functioning (EF) that are present from prodrome to chronic stages of the disease and are related to social and occupational functioning. Recent empirical findings suggest that schizophrenia patients might suffer from a specific speed deficit regarding WM operations that also affects EF. To test this hypothesis, executive functioning (EF) and working memory (WM) performance of 20 schizophrenia (SC) patients, 20 patients suffering from Major Depressive Disorder (MDD) and 40 healthy control (HC) subjects were compared...
December 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28868239/is-the-association-between-offspring-intelligence-and-parents-educational-attainment-influenced-by-schizophrenia-or-mood-disorder-in-parents
#10
Aja Neergaard Greve, Ole Mors, Erik Lykke Mortensen, Sandra Melanie Meier, John J McGrath, Liselotte Petersen
Results from twin, family, and adoption studies all suggest that general intelligence is highly heritable. Several studies have shown lower premorbid intelligence in individuals before the onset of both mood disorders and psychosis, as well as in children and adolescents at genetic high risk for developing schizophrenia. Based on these findings, we aim to investigate if the association between educational achievement in parents and intelligence in their offspring is influenced by schizophrenia or mood disorder in parents...
September 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740829/no-association-between-symptom-severity-and-mmn-impairment-in-schizophrenia-a-meta-analytic-approach
#11
Molly A Erickson, Matthew Albrecht, Abigail Ruffle, Leah Fleming, Philip Corlett, James Gold
The mismatch negativity (MMN) is an event-related potential that is consistently attenuated in people with schizophrenia. Within the predictive coding model of psychosis, MMN impairment is thought to reflect the same prediction failures that are also thought to underlie the development and crystallization of delusions and hallucinations. However, the true relationship between symptom severity and MMN impairment across studies has not yet been established. The present meta-analysis used meta-regressions to examine the relationship between MMN impairment (quantified as Hedges' g) and PANSS positive and negative symptom totals across 62 and 68 samples, respectively...
September 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740828/omega-3-fatty-acids-related-to-cognitive-impairment-in-patients-with-schizophrenia
#12
Kazumi Satogami, Shun Takahashi, Shinichi Yamada, Satoshi Ukai, Kazuhiro Shinosaki
Cognitive impairment is strongly associated with functional outcome in patients with schizophrenia but its pathophysiology remains largely unclear. Involvement of omega-3 fatty acids in the cognitive function of healthy individuals and patients with neuropsychiatric disease has received increasing attention. The aim of this study was to examine the relationship between omega-3 fatty acids with cognitive function, social function, and psychiatric symptoms in patients with schizophrenia. The subjects included 30 patients with schizophrenia or schizoaffective disorder...
September 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740827/self-versus-informant-reports-on-the-specific-levels-of-functioning-scale-relationships-to-depression-and-cognition-in-schizophrenia-and-schizoaffective-disorder
#13
Julia Ermel, Cameron S Carter, James M Gold, Angus W MacDonald, J Daniel Ragland, Steven M Silverstein, Milton E Strauss, Deanna M Barch
The goal of the current study was to examine the relationships between insight and both cognitive function and depression in schizophrenia and schizoaffective disorder, and to determine if there were similar relationships across diagnostic categories. We examined discrepancies between self and informant reports of function on the Specific levels of function scale as a metric of insight for interpersonal, social acceptance, work and activities. We examined two samples of individuals with schizophrenia and/or schizoaffective disorder (Ns of 188 and 67 respectively)...
September 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740826/epicog-sch-a-brief-battery-to-screen-cognitive-impact-of-schizophrenia-in-stable-outpatients
#14
Silvia Zaragoza Domingo, Julio Bobes, Maria-Paz García-Portilla, Claudia Morralla
Brief batteries in schizophrenia, are needed to screen for the cognitive impact of schizophrenia. We aimed to validate and co-norm the Epidemiological Study of Cognitive Impairment in Schizophrenia (EPICOG-SCH) derived brief cognitive battery. A cross-sectional outpatient evaluation was conducted of six-hundred-seventy-two patients recruited from 234 centers. The brief battery included well-known subtests available worldwide that cover cognitive domains related to functional outcomes: WAIS-III-Letter-Number-Sequencing-LNS, Category Fluency Test-CFT, Logical-Memory Immediate Recall-LM, and Digit-Symbol-Coding-DSC...
June 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740825/nmdar-hypofunction-and-somatostatin-expressing-gabaergic-interneurons-and-receptors-a-newly-identified-correlation-and-its-effects-in-schizophrenia
#15
REVIEW
Fatemah Alherz, Mohammad Alherz, Hashemiah Almusawi
This review investigates the association between N-methyl-d-Aspartate receptor (NMDAR) hypofunction and somatostatin-expressing GABAergic interneurons (SST +) and how it contributes to the cognitive deficits observed in schizophrenia (SZ). This is based on evidence that NMDAR antagonists caused symptoms resembling SZ in healthy individuals. NMDAR hypofunction in GABAergic interneurons results in the modulation of the cortical network oscillation, particularly in the gamma range (30-80 Hz). These gamma-band oscillation (GBO) abnormalities were found to lead to the cognitive deficits observed in the disorder...
June 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740824/associations-between-daily-living-skills-cognition-and-real-world-functioning-across-stages-of-schizophrenia-a-study-with-the-schizophrenia-cognition-rating-scale-japanese-version
#16
Yuko Higuchi, Tomiki Sumiyoshi, Tomonori Seo, Motomu Suga, Tsutomu Takahashi, Shimako Nishiyama, Yuko Komori, Kiyoto Kasai, Michio Suzuki
Cognitive function is impaired in patients with schizophrenia-spectrum disorders, even in their prodromal stages. Specifically, the assessment of cognitive abilities related to daily-living functioning, or functional capacity, is important to predict long-term outcome. In this study, we sought to determine the validity of the Schizophrenia Cognition Rating Scale (SCoRS) Japanese version, an interview-based measure of cognition relevant to functional capacity (i.e. co-primary measure). For this purpose, we examined the relationship of SCoRS scores with performance on the Brief Assessment of Cognition in Schizophrenia (BACS) Japanese version, a standard neuropsychological test battery, and the Social and Occupational Functioning Assessment Scale (SOFAS), an interview-based social function scale...
March 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740823/is-performance-on-probed-serial-recall-tasks-in-schizophrenia-related-to-duration-of-attentional-blink
#17
David P McAllindon, Philip G Tibbo, Gail A Eskes
Schizophrenia is associated with a deficit in working memory, with the degree of working memory impairment related to the level of social and occupational functioning. This study tests the hypothesis that the working memory deficits in individuals with schizophrenia can be explained by slow processing of visual stimuli, as measured by the attentional blink (AB) task. Individuals with schizophrenia (SC) and controls (HC) were recruited from an early intervention service for psychosis and the local community...
March 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740822/neurological-soft-signs-effects-of-trait-schizotypy-psychological-distress-and-auditory-hallucination-predisposition
#18
Saskia de Leede-Smith, Steven Roodenrys, Lauren Horsley, Shannen Matrini, Erin Mison, Emma Barkus
Schizotypy is regarded as a trait vulnerability for psychotic disorders, yet alone is insufficient for development of a diagnosable disorder. Additional symptoms and psychological distress are necessary for help seeking and transition from an at risk mental state to a clinical diagnosis. The present study investigated the interaction between trait schizotypy, state auditory verbal hallucination (AVH) predisposition, distress and handedness for the expression of neurological soft signs (NSS), a neurodevelopmental vulnerability factor for psychosis...
March 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740821/validating-the-construct-of-aberrant-salience-in-schizophrenia-behavioral-evidence-for-an-automatic-process
#19
Teresa Katthagen, Felix Dammering, Norbert Kathmann, Jakob Kaminski, Henrik Walter, Andreas Heinz, Florian Schlagenhauf
Suspecting significance behind ordinary events is a common feature in psychosis and it is assumed to occur due to aberrant salience attribution. The Salience Attribution Test (SAT; Roiser et al., 2009) measures aberrant salience as a bias towards one out of two equally reinforced cue features as opposed to adaptive salience towards features indicating high reinforcement. This is the first study to validate the latent constructs involved in salience attribution in patients. Forty-nine schizophrenia patients and forty-four healthy individuals completed the SAT, a novel implicit salience paradigm (ISP), a reversal learning task and a neuropsychological test battery...
December 2016: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740820/compared-to-high-and-low-cannabis-use-moderate-use-is-associated-with-fewer-cognitive-deficits-in-psychosis
#20
Ashley M Schnakenberg Martin, Kelsey A Bonfils, Beshaun J Davis, Elizabeth A Smith, Kelly Schuder, Paul H Lysaker
Literature on the relationship of cannabis use and cognition in schizophrenia provides the paradoxical view that cannabis use is sometimes linked with less severe impairment in neurocognition. This paper explored the possibility that this is a reflection of a dose related response between lifetime cannabis use and two forms of cognition, neurocognition and metacognition, in schizophrenia. It was hypothesized that three groups of patients could be differentiated, those with (1) little to no cannabis use with poor levels of cognition, (2) moderate cannabis use and relatively better levels of cognition and (3) high cannabis use with relatively poorer levels of cognition...
December 2016: Schizophrenia Research. Cognition
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