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MicroRNA

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https://www.readbyqxmd.com/read/28699479/micrornas-based-therapy-a-novel-and-promising-strategy-for-cancer-treatment
#1
Ramona Moles
MicroRNAs are short non-coding RNAs involved in critical biological processes. In the past decade, the deregulation of miRNAs has been well-documented in a wide range of human diseases, including cancer. Overexpression and downregulation of miRNAs affect cellular pathways that contribute to carcinogenesis and tumor progression. This evidence makes miRNAs a suitable candidate for therapeutic applications and leads to developing strategies to manipulate their expression. Consistently, in vitro and in vivo studies show that Let-7, miR-10b, miR-21, miR-34, and miR-221 are promising targets to develop a miRNAs-based therapy for human malignancies...
July 10, 2017: MicroRNA
https://www.readbyqxmd.com/read/28523997/differences-in-relative-levels-of-88-micrornas-in-various-regions-of-the-normal-adult-human-brain
#2
Elena Vladislavovna Filatova, Anelya Khanlarovna Alieva, Maria Igorevna Shadrina, Petr Andreevich Slominsky
AIM OF STUDY: Since the discovery of microRNAs (miRNAs) in the 1990s, our knowledge about their biology has grown considerably. The increasing number of studies addressing the role of miRNAs in development and in various diseases emphasizes the need for a comprehensive catalogue of accurate sequence, expression and conservation information regarding the large number of miRNAs proposed recently in all organs and tissues. The objective of this study was to provide data on the levels of miRNA expression in 15 tissues of the normal human brain...
May 19, 2017: MicroRNA
https://www.readbyqxmd.com/read/28523996/micro-rnas-exercise-and-cellular-plasticity-in-humans-the-impact-of-dietary-factors-and-hypoxia
#3
Timothée Watier, Anthony Mj Sanchez
Physical exercise is a stress that modulates a plethora of cellular mechanisms to promote morphological and metabolic adaptations. Substantial efforts have been made to better understand the modulation of pathways involved in cell plasticity during exercise, but human explorations may be limited because invasive procedures are often required. In recent years, minimally invasive methods for the analysis of microRNAs (miRNAs) modulation in response to exercise have been developed. miRNAs are small molecules that belong to a family of non-coding RNAs...
May 19, 2017: MicroRNA
https://www.readbyqxmd.com/read/28494721/m6a-modification-and-implications-for-micrornas
#4
Ayse Elif Erson-Bensan, Oguzhan Begik
RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes. Here, we review recent literature on m6A modification and potential implications for microRNA (miRNA) mediated gene expression regulation. These implications involve miRNA biogenesis, mRNA-miRNA interactions and m6A target selection...
May 10, 2017: MicroRNA
https://www.readbyqxmd.com/read/28294076/microrna-biogenesis-in-hypoxia
#5
Veronika Bandara, Michael Zenon Michael, Jonathan Mark Gleadle
MicroRNAs (miRNAs) are 17-22 nucleotide, non-coding, single stranded RNA molecules that play a key role in post-transcriptional gene regulation. Hypoxia is a reduction in the normal level of tissue oxygen (O2) tension, and is a feature of chronic vascular disease, pulmonary disease and many cancers. Tissue hypoxia can have widespread effects on cellular functions, as O2 availability is critical for many cellular processes. Cells respond to changes in O2 tension through multiple molecular and cellular mechanisms, including changes in gene expression through transcriptional and translational mechanisms...
March 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/28215140/position-based-nucleotide-analysis-of-mir168-family-in-higher-plants-and-its-targets-in-mammalian-transcripts
#6
Mohammed Javed, Manish Solanki, Anshika Sinha, Lata Israni Shukla
The conserved miR168 family is evaluated for position based nucleotide preference in higher plants. The mature miRNA sequences include miR168-5p and miR168-3p, were obtained from miRBase (v21, June 2014) for 15 families (28 plants) containing a-c subfamilies. The preferred position based nucleotide sequences were obtained for miR168-5p and miR168-3p using Data Analysis in Molecular Biology and Evolution (DAMBE). miR168-5p shows same nucleotides at positions 1-6, 8-9, 11-12, 15-17 and 19. Also, miR168-3p is present in 3 families (10 plants) shows the same nucleotide at position 1-11, 13-15 and 17-21...
February 15, 2017: MicroRNA
https://www.readbyqxmd.com/read/28124611/immunemir-a-database-of-prioritized-immune-mirna-disease-associations-and-its-interactome
#7
Archana Prabahar, Jeyakumar Natarajan
MicroRNAs are the key regulators of gene expression and their abnormal expression in the immune system may be associated with several human diseases such as inflammation, cancer and autoimmune diseases. Elucidation of microRNA (miRNA) disease association through the interactome will deepen the understanding of its disease mechanisms. In this present study, miRNAs specific to immune related diseases were retrieved from curated databases and literature based on MeSH classification of immune system diseases. In total 245 immune miRNAs associated with 92 OMIM disease categories were identified and they are prioritized to specific immune diseases using random walk ranking algorithm...
January 17, 2017: MicroRNA
https://www.readbyqxmd.com/read/28103776/small-and-hungry-micrornas-in-micronutrient-homeostasis-of-plants
#8
Prashanti Patel, Karuna Yadav, Thumballi Ramabhatta Ganapathi
MicroRNAs are emerging players in plant development and response to stresses, both biotic and abiotic such as micronutrient deficiency. These small RNAs regulate cognate downstream targets either by transcript cleavage or translational inhibition. Micronutrient deficiencies lead to poor quality and yield of crops and impaired human health. Over the years several microRNAs have been identified which regulate expression of genes controlling uptake, mobilization and homeostasis of macronutrients such as nitrogen, phosphorus and sulfur to ensure sufficiency without toxicity...
January 17, 2017: MicroRNA
https://www.readbyqxmd.com/read/28088915/evaluation-of-microrna-stability-in-plasma-and-serum-from-healthy-dogs
#9
Lars Enelund, Lise Nikolic Nielsen, Susanna Cirera
BACKGROUND: Early and specific detection of cancer is of great importance for successful treatment of the disease. New biomarkers, like microRNAs, could improve treatment efficiency and survival ratio. In human medicine, deregulation of microRNA profiles in circulation has shown great potential as a new type of biomarker for cancer diagnostics. There are, however, few studies of circulating microRNAs in dogs. Extracellular circulating microRNAs have shown a high level of stability in human blood and other body fluids...
January 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/28056747/micrornas-based-predictor-factor-in-patients-with-migraine-ischemic-stroke
#10
Luca Gallelli, Antonio Siniscalchi, Marco Carotenuto, Maria Cristina Caroleo, Erika Cione, Vincenzo Guidetti
Among the clinical spectrum of neurological diseases, migraine is often associated with cerebro-vasculopathy. Impairment of neuroimmune mediators in the central nervous system has been recognized in the pathophysiology of migraine-related stroke. Although genetic correlation was found in patients with migraine-related stroke, the epidemiology of this disease indicate a need in biomarker searching discovery and validation. In this view, small molecule, called microRNAs (miRNAs), able to regulate immune and neuronal processes has been reported in patients with migraine and ischemic stroke and unambiguous miRNAs related to these diseases could be established as new molecular indicator of precocity for clinical and/or pharmacological intervention...
January 4, 2017: MicroRNA
https://www.readbyqxmd.com/read/27928946/exploring-mechanisms-of-microrna-downregulation-in-cancer
#11
Marissa Williams, Yuen Yee Cheng, Cherie Blenkiron, Glen Reid
MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression at a post-transcriptional level. Each miRNA controls the expression of multiple messenger RNAs (mRNAs) and their dysregulation has been implicated in multiple cancer phenotypes. While some miRNAs are upregulated, global downregulation of miRNA expression is often the rule in cancer. A multitude of potential mechanisms drive aberrant miRNA expression in cancer; miRNA coding regions can harbour genomic defects including mutations, amplifications or deletions, and some miRNAs are broadly repressed by transcription factors such as Myc or have epigenetic modifications to their promoter regions such as hypermethylation of CpG islands...
December 8, 2016: MicroRNA
https://www.readbyqxmd.com/read/27897122/bioinformatics-analysis-of-chicken-mirnas-associated-with-monocyte-to-macrophage-differentiation-and-subsequent-ifng-stimulated-activation
#12
Kristopher Jl Irizarry, Adam Chan, Derek Kettle, Steven Kezian, Dominic Ma, Louis Palacios, Qingshun Li, Calvin L Keeler, Yvonne Drechsler
The goal of this project was to characterize the molecular and cellular roles of various gene targets regulated by 8 miRNAs in differentiating macrophages. Among a number of miRNAs that are found to be expressed in avian macrophages, we focused on eight specific miRNAs (miR-1618, miR-1586, miR-1633, miR-1627, miR-1646, miR-1649, miR-1610, miR-1647) associated with macrophage activation through Wnt signaling, ubiquitination, PPAR mediated macrophage function, vesicle mediated cytokine trafficking, and WD40 domain proteins in macrophage differentiation...
November 29, 2016: MicroRNA
https://www.readbyqxmd.com/read/27834139/microrna-130a-regulation-of-desmocollin-2-in-a-novel-model-of-arrhythmogenic-cardiomyopathy
#13
Stefan R Mazurek, Tyler Calway, Cynthia Harmon, Priyanka Farrell, Gene H Kim
BACKGROUND: MicroRNAs are small noncoding RNA molecules that play a critical role in regulating physiological and disease processes. Recent studies have now recognized microRNAs as an important player in cardiac arrhythmogenesis. Molecular insight into arrhythmogenic cardiomyopathy (AC) has primarily focused on mutations in desmosome proteins. To our knowledge, models of AC due to microRNA dysregulation have not been reported. Previously, we reported on miR-130a mediated down-regulation of Connexin43...
November 9, 2016: MicroRNA
https://www.readbyqxmd.com/read/27568793/aberrant-expression-of-micrornas-in-b-cell-lymphomas
#14
Carla Sole, Erika Larrea, Lorea Manterola, Ibai Goicoechea, Maria Armesto, Maria Arestin, Maria Caffarel, Angela Araujo, Marta Fernandez, Maria Araiz, Charles Lawrie
B-cell lymphomas represent a heterogeneous collection of more than twenty-five different malignancies. Classification is often challenging as primarily based upon, sometimes subjective, histopathological criteria and misdiagnosis can result in inappropriate treatment decisions. MicroRNAs (miRNAs) hold great promise as novel biomarkers (diagnostic, prognostic and predictive) of B-cell lymphoma in addition to being potential therapeutic targets. The most promising of these miRNAs more often than not play key regulatory roles in lymphopoiesis (development of lymphocytes) when under physiological conditions, and in the pathology of lymphoid malignancies when aberrantly expressed...
August 25, 2016: MicroRNA
https://www.readbyqxmd.com/read/27457069/the-yin-and-yang-of-microrna-assay-methods
#15
Jean-Paul Issartel, Audrey Guttin, Hélène Ipas, Maud Barbado, Catherine Mouret, Emmanuel Garcion
OBJECTIVE: microRNA assessments in biological samples can be performed by different methods that mainly rely on hybridization process, qPCR or RNA sequencing. With the aim to detect and validate microRNA biomarkers in tumor samples, we challenged the consistency of the quantitative results obtained with the different methods. METHODS: We measured microRNA concentrations in several biological samples such as cultured tumor cells or tumor tissues (frozen tissues or FFPE samples) using different microRNA assay methods, in particular hybridization to AffymetrixTM arrays, qPCR and digital droplet qPCR (BioradTM) based on Taqman microRNA assays (Life TechnologiesTM)...
July 25, 2016: MicroRNA
https://www.readbyqxmd.com/read/26861895/retraction-notice-generation-of-knock-down-tools-for-transcription-factor-7-like-2-tcf7l2-and-evaluation-of-its-expression-pattern-in-developing-chicken-optic-tectum
#16
(no author information available yet)
The publishers have decided to retract the manuscript entitled "Generation of Knock Down Tools for Transcription Factor 7-Like-2 (TCF7L2) and Evaluation of its Expression Pattern in Developing Chicken Optic Tectum" published in MicroRNA, volume 4, issue 3, page numbers 209-216, 2015, for the following reasons. • Due to conflict of interests between authors and the Principal Investigator.
February 9, 2016: MicroRNA
https://www.readbyqxmd.com/read/28105907/identification-and-characterization-of-novel-mirnas-in-chlamydomonas-reinhardtii-by-computational-methods
#17
Behzad Hajieghrari, Naser Farrokhi, Bahram Goliaei, Kaveh Kavousi
BACKGROUND: MicroRNAs (miRNAs) are endogenous small non-coding RNAs with 18-24 nucleotides in length, which have important roles in posttranscriptional gene regulation. The resemblance of miRNA biogenesis in unicellular green algae and those in plants suggests probable evolutionary conserved pathways. This conservation provides a ground towards prediction of new homologs via computational biology. METHODS: Here, conserved miRNA genes in Chlamydomonas reinhardtii and plants were examined through homology alignment...
2016: MicroRNA
https://www.readbyqxmd.com/read/28105906/preface-microrna-as-disease-biomarkers
#18
A Pulliero, A Izzotti
No abstract text is available yet for this article.
2016: MicroRNA
https://www.readbyqxmd.com/read/28105905/the-yin-and-yang-of-microrna-assay-methods
#19
Audrey Guttin, Helene Ipas, Maud Barbado, Catherine Mouret, Emmanuel Garcion, Jean-Paul Issartel
OBJECTIVE: microRNA assessments in biological samples can be performed by different methods that mainly rely on hybridization process, qPCR or RNA sequencing. With the aim to detect and validate microRNA biomarkers in tumor samples, we challenged the consistency of the quantitative results obtained with the different methods. METHODS: We measured microRNA concentrations in several biological samples such as cultured tumor cells or tumor tissues (frozen tissues or FFPE samples) using different microRNA assay methods, in particular hybridization to AffymetrixTM arrays, qPCR and digital droplet qPCR (BioradTM) based on Taqman microRNA assays (Life TechnologiesTM)...
2016: MicroRNA
https://www.readbyqxmd.com/read/27966400/editorial-overview-on-micrornas-in-cancer-development-and-virus-infection
#20
EDITORIAL
Palmiro Poltronieri
No abstract text is available yet for this article.
2016: MicroRNA
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