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MicroRNA

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https://www.readbyqxmd.com/read/29766833/human-micrornas-expression-profiles-in-influenza-b-virus-infected-cells-based-on-illumina-miseq-platform
#1
Kritsada Khongnomnan, Witthaya Poomipak, Kesmanee Praianantathavorn, Suthat Sangchuwong, Trairak Pisitkun, Yong Poovorawan, Sunchai Payungporn
BACKGROUND: Influenza B virus causes influenza-like illness in humans. MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression through mRNA degradation or translational repression. MiRNAs have evolved to regulate many cellular processes including the viral infection response. OBJECTIVE: This study aims to investigate the miRNA profiles of human cells infected with influenza B virus. METHODS: A549 cells were infected with influenza B viruses (MOI = 0...
May 14, 2018: MicroRNA
https://www.readbyqxmd.com/read/29714155/investigating-the-isolation-and-amplification-of-micrornas-for-forensic-body-fluid-identification
#2
Claire L Glynn, Kelsie R O Leary
BACKGROUND: The discovery of forensic DNA typing evolved molecular biology far beyond what could have been expected in terms of its forensic application, and now there exists other developments in molecular biology which are ready for application to forensic challenges. One such challenge is the identification of the body fluid source of stains recovered from evidence items and crime scenes. Currently there are significant efforts in the research field to develop novel methods for the molecular identification of body fluids, with microRNAs (miRNAs) revealing great potential...
April 30, 2018: MicroRNA
https://www.readbyqxmd.com/read/29701140/expression-of-plasma-hsa-mir122-in-hbv-related-hepatocellular-carcinoma-hcc-in-vietnamese-patients
#3
Nguyen Bao Quoc, Nguyen Doan Nguyen Phuong, Tang Kim Ngan, Nguyen Thi Minh Linh, Pham Hung Cuong, Nguyen Ngoc Bao Chau
BACKGROUND: Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in the world and considered as one of the most susceptible cancers in humans. The microRNA molecule, hsa-miR122, considered as a potential biological marker linked with the injury of hepatocellular tissue, is the most common microRNA in human liver cancer. Understanding the expression profile of hsa-miR122 plays an important role in the diagnosis of HCC Objective: Identification and comparison of cut-off values of plasma hsa-miR122 expression were conducted in blood samples of healthy control, HBV infected and HBV-related HCC Vietnamese patients Method and result: Fifty-two blood samples of healthy control and HBV-related HCC cases, collected between 2015 and 2017 were obtained from Ho Chi Minh City Oncology Hospital, Vietnam...
April 27, 2018: MicroRNA
https://www.readbyqxmd.com/read/29658445/improved-detection-of-circulating-mirnas-in-serum-and-plasma-following-rapid-heat-freeze-cycling
#4
Peter D Mariner, Armin Korst, Anis Karimpour-Fard, Brian L Stauffer, Shelley D Miyamoto, Carmen C Sucharov
BACKGROUND: The measurement of circulating miRNAs has proven to be a powerful biomarker tool for several disease processes. Current protocols for the detection of miRNAs usually involve an RNA extraction step, requiring a substantial volume of patient serum or plasma to obtain sufficient input material. OBJECTIVE: Here, we describe a novel methodology that allows detection of a large number of miRNAs from a small volume of serum or plasma without the need for RNA extraction...
April 16, 2018: MicroRNA
https://www.readbyqxmd.com/read/29607782/influence-of-overweight-and-obesity-on-circulating-inflammation-related-microrna
#5
Jamie G Hijmans, Kyle J Diehl, Tyler D Bammert, Philip J Kavlich, Grace M Lincenberg, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
BACKGROUND: Increased cardiovascular disease risk and prevalence associated with overweight and obesity is due, in part, to heightened inflammatory burden. The mechanisms underlying adiposity-related amplification of inflammation are not fully understood. Alterations in regulators of inflammatory processes such as microRNAs (miRs), however, is thought to play a pivotal role. OBJECTIVE: The aim of this study was to determine the influence of overweight and obesity, independent of other cardiovascular risk factors, on circulating expression of miR-34a, miR-126, miR-146a, miR-150 and miR-181b...
April 2, 2018: MicroRNA
https://www.readbyqxmd.com/read/29595121/the-expansion-segments-of-human-28s-rrna-match-micrornas-much-above-18s-rrna-or-core-segments
#6
Michael S Parker, Ambikaipakan Balasubramaniam, Steven L Parker
The size of eukaryotic 25-28S rRNAs shows a progressive phylogenetically linked increase which is pronounced in mammals, and especially in hominids. The increase is confined to specific expansion segments, inserted at points that are highly conserved from yeast to man. These segments also show a progressive increase in nucleotide bias, mostly the GC bias. Substantial parts of the large expansion segments 7, 15 and 27 of 28S rRNA are known to be exposed at the ribosome surface, with no clear association with ribosomal proteins...
March 28, 2018: MicroRNA
https://www.readbyqxmd.com/read/29595120/state-of-the-art-on-viral-micrornas-in-hpv-infection-and-cancer-development
#7
Palmiro Poltronieri, Binlian Sun, Kai-Yao Huang, Tzu-Hao Chang, Tzong-Yi Lee
BACKGROUND: high-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers. OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs. METHOD: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, presence of hairpins, and validation by comparison with RNA sequencing datasets...
March 27, 2018: MicroRNA
https://www.readbyqxmd.com/read/29564990/impact-of-delayed-whole-blood-processing-time-on-plasma-levels-of-mir-1-and-mir-423-5p-up-to-24-hours
#8
Danielle Pazzotti Borges, Edecio Cunha-Neto, Edimar A Bocchi, Vagner Oliveira Carvalho Rigaud
BACKGROUND: Circulating cell-free miRNAs hold great promise as a new class of biomarkers due to their high stability in body fluids and association with disease stages. However, even using sensitive and specific methods, technical challenges are associated with miRNA analysis in body fluids. A major source of variation in plasma and serum is the potential cell-derived miRNA contamination from hemolysis. OBJECTIVES: To evaluate the effect of the delayed whole blood processing time on the concentrations of miR-1 and -423-5p...
March 21, 2018: MicroRNA
https://www.readbyqxmd.com/read/29437031/underexpression-of-mir-486-5p-but-not-overexpression-of-mir-155-is-associated-with-lung-cancer-stages
#9
Marwa A Mohamed, Ehab I Mohamed, Samir A Abd El-Kaream, Mohamed I Badawi, Samy H Darwish
BACKGROUND: Evidence is increasing that microRNAs (miR) are particularly important in lung homeostasis and development and have been shown to be involved in many pulmonary diseases such as asthma, chronic obstructive pulmonary disease, sarcoidosis, lung cancer (LC) and other smoking-related diseases. OBJECTIVE: The objective of this study was to investigate the expression of miR-155 and miR-486-5p in tissues from LC patients and healthy endobronchial mucosa as prognostic biomarkers for diagnosing LC...
February 12, 2018: MicroRNA
https://www.readbyqxmd.com/read/29412128/variation-in-immune-related-micrornas-profile-in-human-milk-amongst-lactating-women
#10
Mariarita Perri, Maria Lucente, Roberto Cannataro, Ida Francesca De Luca, Luca Gallelli, Guido Moro, Giovambattista De Sarro, Maria Cristina Caroleo, Erika Cione
BACKGROUND: Human milk (HM) is a biological fluid representing the first nutriment for newborns. It directly impacts the development of the infant's immune system. In this concern, specific microRNAs (miRNAs) such as hsa-miR-21, hsa-miR-181a, hsa-miR-150 and hsa-miR-223 are known to be involved in the innate and acquired immune response. OBJECTIVE: Herein, these miRNAs were evaluated in frozen and pasteurized samples of human colostrum and HM in order to elucidate the distribution and the expression profile of these biological mediators in both biological fluids...
February 6, 2018: MicroRNA
https://www.readbyqxmd.com/read/29412127/investigating-the-association-between-mir-608-rs4919510-and-mir-149-rs2292832-with-colorectal-cancer-in-iranian-population
#11
Reza Ranjbar, Vahid Chaleshi, Hamid Asadzadeh Aghdaei, Saeid Morovvati
BACKGROUND: Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) networks may serve as diagnostic and prognostic biomarkers of a variety of diseases such as cancer. Some studies have been performed to examine associations between miR-149 and miR-608 polymorphisms and susceptibility to colorectal cancer, but the results remain controversial and race-dependent. OBJECTIVE: The aim of our study was to investigate the association of miR-608 (rs4919510) and miR-149 (rs2292832) with colorectal cancer and its clinical features in a sample of Iranian population...
February 6, 2018: MicroRNA
https://www.readbyqxmd.com/read/29380708/technology-of-rna-interference-in-advanced-medicine
#12
Fatemeh Abedini, Mohammad Ebrahimi, Hossein Hosseinkhani
RNA interference (RNAi) and related pathways involving small interfering RNAs (siRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs (piRNAs) regulate processes such as anti-viral defense, genome surveillance, heterochromatin formation, and gene expression in animals, plants, and fungi. Studies on RNAi have revealed a two-step mechanism: (i) Degradation of dsRNA into small interfering RNAs (siRNAs), 21 to 25 nucleotides long, by an RNase III-like activity. (ii) The siRNAs join an RNase complex, RISC (RNA-induced silencing complex), which acts on the mRNA and degrades it...
January 29, 2018: MicroRNA
https://www.readbyqxmd.com/read/29299995/mirna-and-proteomic-dysregulation-in-non-small-cell-lung-cancer-in-response-to-cigarette-smoke
#13
Niraj Babu, Jayshree Advani, Hitendra S Solanki, Krishna Patel, Ankit P Jain, Aafaque Ahmad Khan, Aneesha Radhakrishnan, Nandini A Sahasrabuddhe, Premendu Prakash Mathur, Bipin Nair, T S Keshava Prasad, Xiaofei Chang, David Sidransky, Harsha Gowda, Aditi Chatterjee
BACKGROUND: Dysregulation of miRNAs is associated with the development of non-small cell lung cancer (NSCLC). It is imperative to study the dysregulation of miRNAs by cigarette smoke which will affect their targets, either leading to the overexpression of oncoproteins or downregulation of tumor suppressor proteins. OBJECTIVE AND METHODS: In this study, we carried out miRNA sequencing and SILAC-based proteomic analysis of H358 cells chronically exposed to cigarette smoke condensate...
January 3, 2018: MicroRNA
https://www.readbyqxmd.com/read/29648524/preface-the-wealth-of-microrna-kingdom-from-plant-defense-to-cancer-prevention
#14
Alberto Izzotti
No abstract text is available yet for this article.
2018: MicroRNA
https://www.readbyqxmd.com/read/29372676/comparison-of-mirna-evolution-and-function-in-plants-and-animals
#15
Yu Zhang, Ze Yun, Liang Gong, Hongxia Qu, Xuewu Duan, Yueming Jiang, Hong Zhu
MicroRNAs (miRNAs), as a major player in post-transcriptional regulation of gene expression, have been reported to regulate a broad variety of key biological processes, including growth, development and stress responses in both plants and animals. While the biogenesis and regulatory abilities of miRNAs have been extensively studied, the evolutionary history of miRNAs still needs more exploration. So far, several models explain the origination of plant and animal MIRNA (MIR) genes. Both inter-species and intra-species conservation and divergence of miRNAs exhibits functional adaptation to changing environments in evolution...
2018: MicroRNA
https://www.readbyqxmd.com/read/29336272/let-7-mirna-precursors-co-express-with-lin28b-in-cervical-cells
#16
Aida Margarita Zamora-Contreras, Luis Marat Alvarez-Salas
BACKGROUND: The let-7 microRNAs (miRNAs) are frequently dysregulated in carcinogenic processes, including cervical cancer. LIN28 proteins regulate let-7 biogenesis by binding to conserved sequences within the pre-miRNA structure. Nevertheless, recent research has shown that some let-7 miRNAs may escape LIN28 regulation. OBJECTIVE: Correlate pre-let-7 miRNAs and LIN28B levels in cervical cell lines with different malignancy and HPV content. METHODS: Pre-let-7 levels were determined by RTqPCR...
2018: MicroRNA
https://www.readbyqxmd.com/read/29237394/prediction-of-mirna-and-identification-of-their-relationship-network-related-to-late-blight-disease-of-potato
#17
Animesh Kumar, Mohammad Samir Farooqi, D C Mishra, Sanjeev Kumar, Anil Rai, K K Chaturvedi, S B Lal, Anu Sharma
Late blight, is one of the most serious disease in potato caused by Phytophthora infestans. In spite of adopting so many agricultural practices this disease is still a threat for potato. Recent studies showed that microRNA (miRNA), an important gene expression regulator, plays a very important role in host-pathogen interaction by silencing genes either by destructing or blocking of translation of mRNA. To date only few miRNA have been discovered which are related to late blight disease of potato during host pathogen interaction...
December 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/29237393/micrornas-downregulation-in-cancer-is-associated-with-guanine-enrichment-in-the-terminal-loop-sequences-of-their-precursors
#18
Amit Cohen, Mario Alberto Burgos-Aceves, Yoav Smith
A global repression in microRNA (miRNA) expression is a phenomenon observed in different types of cancer. Herein, we show an association of miRNAs downregulation in cancer, with guanine (G) enrichment in the terminal loop sequences of their precursors. High G (and GG) content was mostly found in repressed miRNAs of breast, lung and ovary cancers, predominantly in poorly differentiated tumors. The mature sequences of repressed miRNAs had significantly low G level and were enriched with an ACA motif. These results suggest a new link between G enrichment of precursor miRNAs terminal loops and carcinogenesis, and the possible association of specific sequence motifs with the regulation of their expression...
December 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/29237392/chronic-exposure-of-cigarette-smoke-and-chewing-tobacco-alters-expression-of-micrornas-in-esophageal-epithelial-cells
#19
Aafaque Ahmad Khan, Jayshree Advani, Krishna Patel, Vishalakshi Nanjappa, Keshava K. Datta, Hitendra Singh Solanki, Prashant Kumar, Premendu Prakash Mathur, Bipin Nair, T S Keshava Prasad, Aditi Chatterjee, Harsha Gowda
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers with high mortality rate. Cigarette smoke and chewing tobacco are well known risk factors associated with ESCC. However, molecular mechanisms associated with development of ESCC among smokers and chewers are poorly understood. MicroRNAs play an important role in regulating physiological and disease processes including esophageal cancer. OBJECTIVE AND METHODS: In this study, we developed an in vitro model by treating non-neoplastic Het-1A esophageal cell line with cigarette smoke and chewing tobacco...
December 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/29034845/predicting-mirna-association-with-corresponding-target-genes-and-single-nucleotide-polymorphisms-in-altered-renal-pathophysiology
#20
Pradeep Jaswani, Swayam Prakash, Suraksha Agrawal, Narayan Prasad, Raj Kumar Sharma
BACKGROUND: Translational research on miRNAs develops reliable biomarkers for diagnosis and prognosis of renal diseases. Bioinformatic analyses and systems biology could drive the research for knowing new informative miRNA targets. OBJECTIVES: This study proposes an approach to identify miRNA specific significant target genes, and single nucleotide polymorphisms (SNPs) associated with renal pathophysiology. METHODS: miRNAs were selected after removing duplicity, on the basis of techniques used, and disease spectrum width score...
December 6, 2017: MicroRNA
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