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MicroRNA

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https://www.readbyqxmd.com/read/29336272/let-7-mirna-precursors-co-express-with-lin28b-in-cervical-cells
#1
Alvarez-Salas, Zamora-Contreras
BACKGROUND: The let-7 microRNAs (miRNAs) are frequently dysregulated in carcinogenic processes, including cervical cancer. LIN28 proteins regulate let-7 biogenesis by binding to conserved sequences within the pre-miRNA structure. Nevertheless, recent research has shown that some let-7 miRNAs may escape LIN28 regulation. OBJECTIVE: Correlate pre-let-7 miRNAs and LIN28B levels in cervical cell lines with different malignancy and HPV content. METHODS: Pre-let-7 levels were determined by RTqPCR...
January 15, 2018: MicroRNA
https://www.readbyqxmd.com/read/29299995/mirna-and-proteomic-dysregulation-in-non-small-cell-lung-cancer-in-response-to-cigarette-smoke
#2
Niraj Babu, Jayshree Advani, Hitendra S Solanki, Krishna Patel, Ankit P Jain, Aafaque Ahmad Khan, Aneesha Radhakrishnan, Nandini A Sahasrabuddhe, Premendu Prakash Mathur, Bipin Nair, T S Keshava Prasad, Xiaofei Chang, David Sidransky, Harsha Gowda, Aditi Chatterjee
BACKGROUND: Dysregulation of miRNAs is associated with the development of non-small cell lung cancer (NSCLC). It is imperative to study the dysregulation of miRNAs by cigarette smoke which will affect their targets, either leading to the overexpression of oncoproteins or downregulation of tumor suppressor proteins. OBJECTIVE AND METHODS: In this study, we carried out miRNA sequencing and SILAC-based proteomic analysis of H358 cells chronically exposed to cigarette smoke condensate...
January 3, 2018: MicroRNA
https://www.readbyqxmd.com/read/29237394/prediction-of-mirna-and-identification-of-their-relationship-network-related-to-late-blight-disease-of-potato
#3
Mohammad Samir Farooqi, Animesh Kumar, D C Mishra, Sanjeev Kumar, Anil Rai, K K Chaturvedi, S B Lal, Anu Sharma
Late blight, is one of the most serious disease in potato caused by Phytophthora infestans. In spite of adopting so many agricultural practices this disease is still a threat for potato. Recent studies showed that microRNA (miRNA), an important gene expression regulator, plays a very important role in host-pathogen interaction by silencing genes either by destructing or blocking of translation of mRNA. To date only few miRNA have been discovered which are related to late blight disease of potato during host pathogen interaction...
December 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/29237393/micrornas-downregulation-in-cancer-is-associated-with-guanine-enrichment-in-the-terminal-loop-sequences-of-their-precursors
#4
Amit Cohen, Mario Alberto Burgos-Aceves, Yoav Smith
A global repression in microRNA (miRNA) expression is a phenomenon observed in different types of cancer. Herein, we show an association of miRNAs downregulation in cancer, with guanine (G) enrichment in the terminal loop sequences of their precursors. High G (and GG) content was mostly found in repressed miRNAs of breast, lung and ovary cancers, predominantly in poorly differentiated tumors. The mature sequences of repressed miRNAs had significantly low G level and were enriched with an ACA motif. These results suggest a new link between G enrichment of precursor miRNAs terminal loops and carcinogenesis, and the possible association of specific sequence motifs with the regulation of their expression...
December 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/29237392/chronic-exposure-of-cigarette-smoke-and-chewing-tobacco-alters-expression-of-micrornas-in-esophageal-epithelial-cells
#5
Aafaque Ahmad Khan, Jayshree Advani, Krishna Patel, Vishalakshi Nanjappa, Hitendra S Solanki, Premendu Prakash Mathur, Bipin Nair, T S Keshava Prasad, Aditi Chatterjee, Harsha Gowda
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers with high mortality rate. Cigarette smoke and chewing tobacco are well known risk factors associated with ESCC. However, molecular mechanisms associated with development of ESCC among smokers and chewers are poorly understood. MicroRNAs play an important role in regulating physiological and disease processes including esophageal cancer. OBJECTIVE AND METHODS: In this study, we developed an in vitro model by treating non-neoplastic Het-1A esophageal cell line with cigarette smoke and chewing tobacco...
December 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/29076440/mark1-is-a-novel-target-for-mir-125a-5p-implications-for-cell-migration-in-cervical-tumor-cells
#6
Martínez-Acuña Natalia, González-Torres Alejandro, Tapia-Vieyra Juana Virginia, Alvarez-Salas Luis Marat
BACKGROUND: Aberrant miRNA expression is associated with the development of several diseases including cervical cancer. Dysregulation of miR-125a-5p is present in a plethora of tumors, but its role in cervical cancer is not well understood. OBJECTIVE: To analyze the expression profile of miR-125a-5p in tumor and immortal cell lines with further target prediction, validation and function analysis. METHODS: MiR-125a-5p expression was determined by real-time RT-PCR from nine cervical cell lines...
October 24, 2017: MicroRNA
https://www.readbyqxmd.com/read/29034845/predicting-mirna-association-with-corresponding-target-genes-and-single-nucleotide-polymorphisms-in-altered-renal-pathophysiology
#7
Pradeep Jaswani, Swayam Prakash, Narayan Prasad, Suraksha Agrawal, Raj Kumar Sharma
BACKGROUND: Translational research on miRNAs develops reliable biomarkers for diagnosis and prognosis of renal diseases. Bioinformatic analyses and systems biology could drive the research for knowing new informative miRNA targets. OBJECTIVES: This study proposes an approach to identify miRNA specific significant target genes, and single nucleotide polymorphisms (SNPs) associated with renal pathophysiology. METHODS: miRNAs were selected after removing duplicity, on the basis of techniques used, and disease spectrum width score...
October 16, 2017: MicroRNA
https://www.readbyqxmd.com/read/28901847/micrornas-to-monitor-pain-migraine-and-drug-treatment
#8
Luca Gallelli, Erika Cione, Maria Cristina Caroleo, Marco Carotenuto, Pasqualina Lagana, Antonio Siniscalchi, Vincenzo Guidetti
Migraine is a prevalent neurovascular disorders with a complex pathophysiology and therapeutic options characterized by important side effects or problems related to drug abuse. No specific biomarkers are recognized to be univocal for this subclinical condition, yet. In this concern microRNAs have been suggested as potentially useful screening/diagnostic tool, and research is underway to recognize the most effective candidate(s). microRNAs, able to regulate immune and neuronal processes are herein reported for both, mice models with multiple induced pain conditions and human subjects...
September 12, 2017: MicroRNA
https://www.readbyqxmd.com/read/28875846/computational-identification-of-microrna-17-3p-in-breast-cancer-cells
#9
J S Shincy, Mani Pankal, Jinu Jereena, Giri Yogesh Vengatagiri, Kshirsagar Rahul Vittalrao, Pethanen Sivakumar, Vincent Gopinath, K M Kumar, Durairaj Sekar
MicroRNAs (miRNAs) are small, highly conserved non-coding RNA molecules involved in the RNA silencing and post-transcriptional regulation of gene expression. miRNAs are well conserved in both plants and animals, and are thought to be a vital and evolutionarily ancient component of gene regulation and also act as oncogenes or tumor suppressors. It is known that Express Sequence Tags (EST) are a short sub-sequence of cDNA sequence, which contain information of condition or tissue specific transcripts (coding and non-coding) of an organism...
August 30, 2017: MicroRNA
https://www.readbyqxmd.com/read/28523997/differences-in-relative-levels-of-88-micrornas-in-various-regions-of-the-normal-adult-human-brain
#10
Elena V Filatova, Anelya Alieva, Maria I Shadrina, Petr A Slominsky
AIM OF STUDY: Since the discovery of microRNAs (miRNAs) in the 1990s, our knowledge about their biology has grown considerably. The increasing number of studies addressing the role of miRNAs in development and in various diseases emphasizes the need for a comprehensive catalogue of accurate sequence, expression and conservation information regarding the large number of miRNAs proposed recently in all organs and tissues. The objective of this study was to provide data on the levels of miRNA expression in 15 tissues of the normal human brain...
August 16, 2017: MicroRNA
https://www.readbyqxmd.com/read/28799488/environment-and-neurodegenerative-diseases-an-update-on-mirna-role
#11
Margherita Ferrante, Gea Oliveri Conti
INTRODUCTION: The importance of neurodegenerative diseases on the management of public health is growing and the real role of the environment and miRNA in their occurrence is still unclear. miRNA can affect significantly the regulatory network. The complex variety and gene-regulatory capacity of miRNAs is particularly valuable in the brain, being a very complex organ with a functional specialization of neurons highly adaptable to environmental stimuli. In particular a miRNAs role is demonstrated in neurological diseases as the effect to toxic and mutagenic substances exposure by the environment...
August 11, 2017: MicroRNA
https://www.readbyqxmd.com/read/28782472/canonical-microrna-matching-differs-greatly-across-groups-of-g-protein-coupled-receptor-mrnas
#12
Michael S Parker, Ambikaipakan Balasubramaniam, Floyd R Sallee, Steven L Parker
BACKGROUND: Heptahelical G protein coupled receptors (GPCRs) support numerous sensory and metabolic functions and differ considerably in levels of expression. GPCR protein levels should link to regulation of GPCR mRNAs by microRNAs (miRs), which might significantly depend on numbers, size and GC content of the canonical antisense matches in mRNAs. These parameters of GPCR mRNAs have not been studied in detail. METHODS: Canonical matching profiles of human GPCR mRNAs and miRs were examined using segments of 7-15 nucleotides in windows shifted by one position over the entire microRNA sequence...
August 4, 2017: MicroRNA
https://www.readbyqxmd.com/read/28738777/aberrantly-binding-micrornas-and-their-interactions-with-nuclear-hormone-receptors
#13
Jeyalakshmi Kandhavelu, Suresh Palanivel, Meenakshisundaram Kandhavelu
Nuclear Hormone Receptors (NHRs) are the most important targets that plays vital role in cellular signaling pathways of disease. Regulation of NHRs by using potential non-coding RNAs, miRNA, is clinically important to control a disease. However, the detailed status of miRNA interactions with NHRs remains unclear. Hence, the focus of present study is to investigate the interface at the genome-wide level in human, mouse and rat using computational biology approach. This big-data analysis explored thousands of available miRNAs interactions with the NHRs and the results showed that 11 miRNAs have conserved targets, where six miRNAs genetically conserved among different species...
July 24, 2017: MicroRNA
https://www.readbyqxmd.com/read/28738776/graph-based-clustering-of-mirna-sequences
#14
Viviani A Kasahara, Maria do Carmo Nicoletti
MicroRNAs (miRNAs) are approximately 22 nucleotide-long non-coding RNA molecules, that play important roles in gene regulation. They regulate several processes, such as development, metabolism and cell death, among many others. The many miRNAs discovered so far have been divided into biologically representative families, aiming at organizing and systematizing their study so to promote, mainly, a better understanding of their functionalities. Considering that members of the same miRNA family tend to biologically function in similar ways, a well-structured family can help detecting miRNA functions which have not been associated yet with any existing family...
July 24, 2017: MicroRNA
https://www.readbyqxmd.com/read/28699479/micrornas-based-therapy-a-novel-and-promising-strategy-for-cancer-treatment
#15
Ramona Moles
MicroRNAs are short non-coding RNAs involved in critical biological processes. In the past decade, the deregulation of miRNAs has been well-documented in a wide range of human diseases, including cancer. Overexpression and downregulation of miRNAs affect cellular pathways that contribute to carcinogenesis and tumor progression. This evidence makes miRNAs a suitable candidate for therapeutic applications and leads to developing strategies to manipulate their expression. Consistently, in vitro and in vivo studies show that Let-7, miR-10b, miR-21, miR-34, and miR-221 are promising targets to develop a miRNAs-based therapy for human malignancies...
July 10, 2017: MicroRNA
https://www.readbyqxmd.com/read/28523996/micro-rnas-exercise-and-cellular-plasticity-in-humans-the-impact-of-dietary-factors-and-hypoxia
#16
Timothée Watier, Anthony Mj Sanchez
Physical exercise is a stress that modulates a plethora of cellular mechanisms to promote morphological and metabolic adaptations. Substantial efforts have been made to better understand the modulation of pathways involved in cell plasticity during exercise, but human explorations may be limited because invasive procedures are often required. In recent years, minimally invasive methods for the analysis of microRNAs (miRNAs) modulation in response to exercise have been developed. miRNAs are small molecules that belong to a family of non-coding RNAs...
May 19, 2017: MicroRNA
https://www.readbyqxmd.com/read/28215140/position-based-nucleotide-analysis-of-mir168-family-in-higher-plants-and-its-targets-in-mammalian-transcripts
#17
Mohammed Javed, Manish Solanki, Anshika Sinha, Lata Israni Shukla
The conserved miR168 family is evaluated for position based nucleotide preference in higher plants. The mature miRNA sequences include miR168-5p and miR168-3p, were obtained from miRBase (v21, June 2014) for 15 families (28 plants) containing a-c subfamilies. The preferred position based nucleotide sequences were obtained for miR168-5p and miR168-3p using Data Analysis in Molecular Biology and Evolution (DAMBE). miR168-5p shows same nucleotides at positions 1-6, 8-9, 11-12, 15-17 and 19. Also, miR168-3p is present in 3 families (10 plants) shows the same nucleotide at position 1-11, 13-15 and 17-21...
February 15, 2017: MicroRNA
https://www.readbyqxmd.com/read/28494721/m6a-modification-and-implications-for-micrornas
#18
Ayse Elif Erson-Bensan, Oguzhan Begik
OBJECTIVE: RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes. METHOD: Here, we review recent literature on m6A modification and potential implications for microRNA (miRNA) mediated gene expression regulation...
2017: MicroRNA
https://www.readbyqxmd.com/read/28294076/microrna-biogenesis-in-hypoxia
#19
Kanchana Veronika Bandara, Michael Zenon Michael, Jonathan Mark Gleadle
MicroRNAs (miRNAs) are 17-22 nucleotide, non-coding, single stranded RNA molecules that play a key role in post-transcriptional gene regulation. Hypoxia is a reduction in the normal level of tissue oxygen (O2) tension, and is a feature of chronic vascular disease, pulmonary disease and many cancers. Tissue hypoxia can have widespread effects on cellular functions, as O2 availability is critical for many cellular processes. Cells respond to changes in O2 tension through multiple molecular and cellular mechanisms, including changes in gene expression through transcriptional and translational mechanisms...
2017: MicroRNA
https://www.readbyqxmd.com/read/28124611/immunemir-a-database-of-prioritized-immune-mirna-disease-associations-and-its-interactome
#20
Archana Prabahar, Jeyakumar Natarajan
BACKGROUND: MicroRNAs are the key regulators of gene expression and their abnormal expression in the immune system may be associated with several human diseases such as inflammation, cancer and autoimmune diseases. Elucidation of miRNA disease association through the interactome will deepen the understanding of its disease mechanisms. A specialized database for immune miRNAs is highly desirable to demonstrate the immune miRNA disease associations in the interactome. METHODS: miRNAs specific to immune related diseases were retrieved from curated databases such as HMDD, miR2disease and PubMed literature based on MeSH classification of immune system diseases...
2017: MicroRNA
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