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Movement Disorders Clinical Practice

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https://www.readbyqxmd.com/read/30515448/comment-on-is-it-useful-to-classify-psp-and-cbd-as-different-disorders
#1
Anthony E Lang
No abstract text is available yet for this article.
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515447/neurostimulation-for-functional-neurological-disorder-evaluating-longitudinal-neurophysiology
#2
Matthew J Burke, Reina Isayama, Gaayathiri Jegatheeswaran, Carolyn Gunraj, Anthony Feinstein, Anthony E Lang, Robert Chen
No abstract text is available yet for this article.
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515446/bilateral-basal-ganglia-necrosis-secondary-to-methamphetamine
#3
Andrea Sanchez, Irene A Malaty, Anna Khanna, Katharina Busl, Teddy S Youn, Nandakumar Nagaraja, Wissam Deeb, Matthew McAdams, Michael S Okun, Daniel Martinez-Ramirez
No abstract text is available yet for this article.
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515445/levodopa-carbidopa-intestinal-gel-infusion-therapy-focus-on-gait-and-balance
#4
Vittorio Rispoli, Nico Golfrè Andreasi, Giovanna Penna, Francesca Preda, Eleonora Contini, Mariachiara Sensi
Background: Gait and balance disorders in advanced Parkinson's disease (aPD) heavily impact the disease burden. In this prospective observational open-label study, our aim was to evaluate the effectiveness of levodopa/carbidopa intestinal gel (LCIG) infusion on balance and gait over a long-term follow-up. Methods: The motor status of 15 aPD patients with balance and gait symptoms was assessed with UPDRS (I-IV) and H&Y at baseline in OFF and ON conditions, and after 52 weeks of LCIG infusion...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515444/dyskinesia-hyperpyrexia-syndrome-in-parkinson-s-disease-a-heat-shock-related-emergency
#5
Marianna Sarchioto, Valeria Ricchi, Marta Melis, Marcello Deriu, Roberta Arca, Maurizio Melis, Francesca Morgante, Giovanni Cossu
No abstract text is available yet for this article.
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515443/assessment-scales-for-patients-with-advanced-huntington-s-disease-comparison-of-the-uhdrs-and-uhdrs-fap
#6
Jessica Y Winder, Wilco P Achterberg, Johan Marinus, Sarah L Gardiner, Raymund A C Roos
Background: The standard clinical assessment tool in Huntington's disease is the Unified Huntington's Disease Rating Scale (UHDRS). In patients with advanced Huntington's disease ceiling and floor effects of the UHDRS hamper the detection of changes. Therefore, the UHDRS-For Advanced Patients (UHDRS-FAP) has been designed for patients with late-stage Huntington's disease. Objectives: This cross-sectional study aims to examine if the UHDRS-FAP can differentiate better between patients with advanced Huntington's disease than the UHDRS...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515442/missing-data-in-the-unified-dysksinesia-rating-scale-udysrs
#7
Sheng Luo, Xuehan Ren, Weilu Han, Christopher G Goetz, Glenn T Stebbins
Objective: Identify the number of allowable missing values still permitting valid surrogate score calculation for the Unified Dyskinesia Rating Scale (UDysRS). Background: Missing data frequently occur in Parkinson's disease rating scales, and they compromise data validity, risking data exclusion from final analyses. Methods: Accessing the International Parkinson and Movement Disorder Society-sponsored UDysRS translation databases (3313 complete scores)...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515441/the-outcome-of-dopamine-dysregulation-syndrome-in-parkinson-s-disease-a-retrospective-postmortem-study
#8
Pedro Barbosa, Atbin Djamshidian, Andrew J Lees, Thomas T Warner
Introduction: We have performed a retrospective analysis of the frequency and relation to treatment of dopamine dysregulation syndrome (DDS) using the Queen Square Brain Bank (QSBB) database. Methods: A search of the QSBB database for consecutive cases donated between 2005 and 2016 with a pathological diagnosis of Parkinson's disease was performed. Results: DDS was present in 8.8% of cases, was more prevalent in males, and was associated with younger age of onset, longer disease duration, and more dopa-induced dyskinesias...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515440/the-10-year-landscape-of-united-states-registered-parkinson-disease-clinical-trials-2007-2016
#9
Kara J Wyant, Erika Yasuda, Vikas Kotagal
Background: We know little about how well the goals and results of clinical trials in Parkinson disease (PD) reflect the priorities of patients and the broader PD community. Objectives: We conducted a review of registered trials on http://clincialtrials.gov from 2007 to 2016 to explore whether PD trials have moved closer to the therapeutic priority goals articulated by the PD community. Methods: Using the search terms: Parkinson, interventional trials, phase "0-4," we categorized therapeutic PD studies from http://clinicaltrials...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515439/phenoconversion-from-idiopathic-rapid-eye-movement-sleep-behavior-disorder-to-lewy-body-disease
#10
Tomoyuki Miyamoto, Masayuki Miyamoto
Background: The conversion rate and estimated risk of neurodegenerative diseases vary with idiopathic rapid eye movement sleep behavior disorder (IRBD). Methods: This retrospective cohort study examined 273 patients (213 men, 60 women) with polysomnographic-confirmed IRBD (192 and 81 patients in the Sleep Center [SC] cohort and Neurological Center [NC] cohort, respectively) who were followed longitudinally. The date of diagnosis was determined as the onset of an overt neurological syndrome...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515438/prefrontal-cortical-stimulation-in-tourette-disorder-proof-of-concept-clinical-and-neuroimaging-study
#11
Daniela Perani, Stefania Lalli, Leonardo Iaccarino, Pierpaolo Alongi, Orsola Gambini, Angelo Franzini, Alberto Albanese
Background: The benefits of neurosurgery in Tourette Syndrome (TS) are still incompletely understood. Prefrontal cortical electrical stimulation offers a less invasive alternative to deep brain stimulation. Objective: To perform a pilot assessment on safety and efficacy of prefrontal cortical bilateral electrical stimulation in TS using clinical and brain metabolic assessments. Methods: Four adult TS patients underwent tic assessment using the Yale Global Tic Severity Scale and the Rush Video Rating Scale at baseline and 1, 3, 6, and 12-months after implant; whereas FDG-PET scans were acquired at baseline and after 6 and 12 months...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515437/clinical-rating-scales-for-urinary-symptoms-in-parkinson-disease-critique-and-recommendations
#12
REVIEW
Anne Pavy-Le Traon, Nikki Cotterill, Gerard Amarenco, Susanne Duerr, Horacio Kaufmann, Heinz Lahrmann, François Tison, Gregor K Wenning, Christopher G Goetz, Werner Poewe, Cristina Sampaio, Anette Schrag, Olivier Rascol, Pablo Martinez-Martin, Glenn T Stebbins
Background: The prevalence of lower urinary tract symptoms (LUTS) is high in Parkinson's disease (PD). These problems negatively affect quality of life and include both storage and voiding problems. The International Parkinson and Movement Disorder Society established a task force to review clinical rating scales/questionnaires for the assessment of urinary symptoms in PD. Methods: According to prespecified criteria, these scales/questionnaires were classified as "Recommended" or "Recommended with caveats" when clinimetric properties were satisfactory for Recommended status but had not been assessed specifically in PD, "Suggested" or "Listed...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515436/functional-movement-disorders-and-placebo-a-brief-review-of-the-placebo-effect-in-movement-disorders-and-ethical-considerations-for-placebo-therapy
#13
REVIEW
Bonnie M Kaas, Casey Jo Humbyrd, Alexander Pantelyat
Background: Functional movement disorders are common and disabling neurologic conditions. Patients with functional neurologic disorders represent a large proportion of neurology clinic referrals, and limited availability of subspecialty care creates a considerable burden for the healthcare system. These conditions are currently treated with a combination of physical therapy and cognitive behavioral therapy, with variable success. Methods: We searched the Medline database for studies on the epidemiology and physiology of functional movement disorders, as well as those on the placebo effect in movement disorders...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30515435/understanding-impact-and-communication-of-off-periods-in-parkinson-s-disease-a-scoping-review
#14
REVIEW
Tara Rastgardani, Melissa J Armstrong, Anna R Gagliardi, Connie Marras
Background: Off periods are a common and disabling symptom of Parkinson's disease. We reviewed published research on understanding, impact, and communication regarding off periods to identify issues warranting further research. Methods: We performed a scoping review, searching MEDLINE, EMBASE, Cochrane Library, CINAHL, and PsycINFO from 2006 to January 2018 for studies examining the impact of, understanding of, or communication about off periods. Results: Twenty-six papers met eligibility criteria...
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30363510/rating-scales-and-performance-based-measures-for-assessment-of-functional-ability-in-huntington-s-disease-critique-and-recommendations
#15
Tiago A Mestre, Monica Busse, Aileen M Davis, Lori Quinn, Filipe B Rodrigues, Jean-Marc Burgunder, Noelle E Carlozzi, Francis Walker, Aileen K Ho, Cristina Sampaio, Christopher G Goetz, Esther Cubo, Pablo Martinez-Martin, Glenn T Stebbins
Limitation of functional ability is a major feature of Huntington's disease (HD). The International Parkinson and Movement Disorder Society (MDS) commissioned the appraisal of the use and clinimetric properties of clinical measures of functional ability that have been applied in HD studies and trials to date, to make recommendations regarding their use based on standardized criteria. After a systematic literature search, we included a total of 29 clinical measures grouped into two categories: (1) performance-based measures (e...
July 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30363458/dopamine-receptor-d3-rs6280-is-associated-with-aberrant-decision-making-in-parkinson-s-disease
#16
Roopa Rajan, Syam Krishnan, Gangadhara Sarma, Sankara P Sarma, Asha Kishore
Background: The functional Ser9Gly single nucleotide polymorphism (SNP) in the dopamine D3 receptor gene is associated with impulse control disorders (ICD) in Parkinson's disease (PD) in Indian patients. Whether the same SNP modulates impulsivity in PD patients without active ICD is unknown. We aimed to compare decision-making under uncertainty in PD patients with DRD3 p.S9G (rs6280) variants CT/CC or TT. Methods: We conducted a cross-sectional study including PD patients (n = 78) whose DRD3 p...
July 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30363427/implementing-levodopa-carbidopa-intestinal-gel-for-parkinson-disease-insights-from-us-practitioners
#17
REVIEW
Michelle Burack, Jason Aldred, Cindy Zadikoff, Arvydas Vanagunas, Kevin Klos, Bahri Bilir, Hubert H Fernandez, David G Standaert
Background: Levodopa-carbidopa intestinal gel (LCIG, designated in the United States as carbidopa-levodopa enteral suspension, CLES) was approved in the United States in 2015 for the treatment of refractory motor fluctuations in individuals with Parkinson disease (PD). Many neurologists in the United States have not had personal experience with implementation and management of the unique delivery system for this treatment. Methods and Findings: This educational review was developed to provide practitioners with an understanding of LCIG use from the clinician's point of view...
July 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30363410/subtle-esophageal-motility-alterations-in-parkinsonian-syndromes-synucleinopathies-vs-tauopathies
#18
Inga Claus, Judith Suttrup, Paul Muhle, Sonja Suntrup-Krueger, Marie-Luise Siemer, Frank Lenze, Rainer Dziewas, Tobias Warnecke
Background: Esophageal dysfunction is a frequent phenomenon in Parkinson's disease during all disease stages, but data about esophageal involvement in atypical parkinsonian syndromes as well as possible differences between alpha-synucleinopathies and tauopathies, including causative links to the origin of the dysfunction, are lacking so far. Objective: To describe esophageal alternation patterns in different parkinsonian syndromes and to look for differences supporting the hypothesis of alpha-synuclein aggregation being linked to gastrointestinal impairment in parkinsonian syndromes...
July 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30363394/genetic-dystonia-ataxia-syndromes-clinical-spectrum-diagnostic-approach-and-treatment-options
#19
REVIEW
Malco Rossi, Bettina Balint, Patricio Millar Vernetti, Kailash P Bhatia, Marcelo Merello
Background: Dystonia and ataxia are manifestations of numerous disorders, and indeed, an ever-expanding spectrum of genes causing diseases that encompass dystonia and ataxia are discovered with the advances of genetic techniques. In recent years, a pathophysiological link between both clinical features and the role of the cerebellum in the genesis of dystonia, in some cases, has been proposed. In clinical practice, the genetic diagnosis of dystonia-ataxia syndromes is a major issue for genetic counseling, prognosis and, occasionally, specific treatment...
July 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30363383/association-of-mri-measurements-with-cognitive-outcomes-after-stn-dbs-in-parkinson-s-disease
#20
Laura J Weinkle, Brian Hoyt, John A Thompson, Stefan Sillau, Jody Tanabe, Justin Honce, Olga Klepitskaya
Objectives: Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for improving the motor symptoms of Parkinson's disease (PD). Overall, cognitive function remains stable after STN-DBS in most patients. However, cognitive decline, specifically in the verbal fluency domain, is seen in a subset of STN-DBS patients. Currently, predictors of cognitive decline in PD patients treated with STN-DBS are not well known. Thus, identification of presurgical predictors might provide an important clinical tool for better risk-to-benefit assessment...
July 2018: Movement Disorders Clinical Practice
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