journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Cell and Developmental Biology

journal
https://www.readbyqxmd.com/read/29164114/interorganelle-communication-between-mitochondria-and-the-endolysosomal-system
#1
REVIEW
Gonzalo Soto-Heredero, Francesc Baixauli, María Mittelbrunn
The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29164113/chemokine-signaling-during-midline-epithelial-seam-disintegration-facilitates-palatal-fusion
#2
Christiaan M Suttorp, Niels A Cremers, René van Rheden, Raymond F Regan, Pia Helmich, Sven van Kempen, Anne M Kuijpers-Jagtman, Frank A D T G Wagener
Disintegration of the midline epithelial seam (MES) is crucial for palatal fusion, and failure results in cleft palate. Palatal fusion and wound repair share many common signaling pathways related to epithelial-mesenchymal cross-talk. We postulate that chemokine CXCL11, its receptor CXCR3, and the cytoprotective enzyme heme oxygenase (HO), which are crucial during wound repair, also play a decisive role in MES disintegration. Fetal growth restriction and craniofacial abnormalities were present in HO-2 knockout (KO) mice without effects on palatal fusion...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29164112/details-matter-noise-and-model-structure-set-the-relationship-between-cell-size-and-cell-cycle-timing
#3
Felix Barber, Po-Yi Ho, Andrew W Murray, Ariel Amir
Organisms across all domains of life regulate the size of their cells. However, the means by which this is done is poorly understood. We study two abstracted "molecular" models for size regulation: inhibitor dilution and initiator accumulation. We apply the models to two settings: bacteria like Escherichia coli, that grow fully before they set a division plane and divide into two equally sized cells, and cells that form a bud early in the cell division cycle, confine new growth to that bud, and divide at the connection between that bud and the mother cell, like the budding yeast Saccharomyces cerevisiae...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29119099/wnt-and-hedgehog-signaling-regulate-the-differentiation-of-f9-cells-into-extraembryonic-endoderm
#4
Gurjoth S J Deol, Tina N Cuthbert, Mohamed I Gatie, Danielle M Spice, Lindsay R Hilton, Gregory M Kelly
Mouse F9 cells differentiate into primitive extraembryonic endoderm (PrE) when treated with retinoic acid (RA), and this is accompanied by an up-regulation of Gata6. The role of the GATA6 network in PrE differentiation is known, and we have shown it directly activates Wnt6. Canonical Wnt/β-catenin signaling is required by F9 cells to differentiate to PrE, and this, like most developmental processes, requires input from one or more additional pathways. We found both RA and Gata6 overexpression, can induce the expression of Indian Hedgehog (Ihh) and a subset of its target genes through Gli activation during PrE induction...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29085822/commentary-hnrnpll-a-newly-identified-colorectal-cancer-metastasis-suppressor-modulates-alternative-splicing-of-cd44-during-epithelial-mesenchymal-transition
#5
COMMENT
Somesh Baranwal
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29034233/role-of-cardiolipin-in-mitochondrial-signaling-pathways
#6
REVIEW
Jan Dudek
The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes and plays a role in many mitochondrial processes, including respiration and energy conversion. Pathological changes in CL amount or species composition can have deleterious consequences for mitochondrial function and trigger the production of reactive oxygen species. Signaling networks monitor mitochondrial function and trigger an adequate cellular response. Here, we summarize the role of CL in cellular signaling pathways and focus on tissues with high-energy demand, like the heart...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29034232/maternally-contributed-folate-receptor-1-is-expressed-in-ovarian-follicles-and-contributes-to-preimplantation-development
#7
Trine Strandgaard, Solveig Foder, Anders Heuck, Erik Ernst, Morten S Nielsen, Karin Lykke-Hartmann
Folates have been shown to play a crucial role for proper development of the embryo as folate deficiency has been associated with reduced developmental capacity such as increased risk of fetal neural tube defects and spontanous abortion. Transcripts encoding the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptor FOLR1 are expressed in oocytes and preimplantation embryos, respectively. In this study, we observed maternally contributed FOLR1 protein during mouse and human ovarian follicle development, and 2-cell mouse embryos...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29034231/editorial-the-vascular-niche-in-tissue-repair-a-therapeutic-target-for-regeneration
#8
EDITORIAL
Francisco J Rivera, Maria Elena Silva, Ludwig Aigner
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29021982/autologous-periosteum-derived-micrografts-and-plga-ha-enhance-the-bone-formation-in-sinus-lift-augmentation
#9
Ruggero Rodriguez Y Baena, Riccardo D'Aquino, Antonio Graziano, Letizia Trovato, Antonio C Aloise, Gabriele Ceccarelli, Gabriella Cusella, André A Pelegrine, Saturnino M Lupi
Sinus lift augmentation is a procedure required for the placement of a dental implant, whose success can be limited by the quantity or quality of available bone. To this purpose, the first aim of the current study was to evaluate the ability of autologous periosteum-derived micrografts and Poly(lactic-co-glycolic acid) (PLGA) supplemented with hydroxyl apatite (HA) to induce bone augmentation in the sinus lift procedure. Secondly, we compared the micrograft's behavior with respect to biomaterial alone, including Bio-Oss® and PLGA/HA, commercially named Alos...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29018797/micrornas-make-the-call-in-cancer-personalized-medicine
#10
REVIEW
Simone Detassis, Margherita Grasso, Valerio Del Vescovo, Michela A Denti
Since their discovery and the advent of RNA interference, microRNAs have drawn enormous attention because of their ubiquitous involvement in cellular pathways from life to death, from metabolism to communication. It is also widely accepted that they possess an undeniable role in cancer both as tumor suppressors and tumor promoters modulating cell proliferation and migration, epithelial-mesenchymal transition and tumor cell invasion and metastasis. Moreover, microRNAs can even affect the tumor surrounding environment influencing angiogenesis and immune system activation and recruitment...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28983484/editorial-diacylglycerol-kinase-signalling
#11
EDITORIAL
Isabel Merida, Andrea Graziani, Fumio Sakane
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28983483/a-comprehensive-infrastructure-for-big-data-in-cancer-research-accelerating-cancer-research-and-precision-medicine
#12
Izumi V Hinkson, Tanja M Davidsen, Juli D Klemm, Anthony R Kerlavage, Warren A Kibbe
Advancements in next-generation sequencing and other -omics technologies are accelerating the detailed molecular characterization of individual patient tumors, and driving the evolution of precision medicine. Cancer is no longer considered a single disease, but rather, a diverse array of diseases wherein each patient has a unique collection of germline variants and somatic mutations. Molecular profiling of patient-derived samples has led to a data explosion that could help us understand the contributions of environment and germline to risk, therapeutic response, and outcome...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28983482/editorial-microenvironment-derived-stem-cell-plasticity
#13
EDITORIAL
Jelena Krstic, Marietta Herrmann, Ivana Gadjanski, Slavko Mojsilovic
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28979895/editorial-organogenesis-from-development-to-disease
#14
EDITORIAL
Sunder Sims-Lucas, Misty Good, Seppo J Vainio
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28971094/editorial-emerging-functions-of-septins
#15
EDITORIAL
Manoj B Menon, Matthias Gaestel
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28959689/intermediate-filaments-at-the-junction-of-mechanotransduction-migration-and-development
#16
REVIEW
Rucha Sanghvi-Shah, Gregory F Weber
Mechanically induced signal transduction has an essential role in development. Cells actively transduce and respond to mechanical signals and their internal architecture must manage the associated forces while also being dynamically responsive. With unique assembly-disassembly dynamics and physical properties, cytoplasmic intermediate filaments play an important role in regulating cell shape and mechanical integrity. While this function has been recognized and appreciated for more than 30 years, continually emerging data also demonstrate important roles of intermediate filaments in cell signal transduction...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28959688/editorial-mitogen-activated-protein-kinases
#17
EDITORIAL
Ana Cuenda, José M Lizcano, José Lozano
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28913335/extracellular-vesicle-flow-cytometry-analysis-and-standardization
#18
REVIEW
Joshua A Welsh, Judith A Holloway, James S Wilkinson, Nicola A Englyst
The term extracellular vesicles (EVs) describes membranous vesicles derived from cells, ranging in diameter from 30 to 1,000 nm with the majority thought to be in the region of 100-150 nm. Due to their small diameter and complex and variable composition, conventional techniques have struggled to accurately count and phenotype EVs. Currently, EV characterization using high-resolution flow cytometry is the most promising method when compared to other currently available techniques, due to it being a high-throughput, single particle, multi-parameter analysis technique capable of analyzing a large range of particle diameters...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28913334/editorial-signaling-pathways-in-embryonic-development
#19
EDITORIAL
Juan J Sanz-Ezquerro, Andrea E Münsterberg, Sigmar Stricker
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28894736/synthetic-gene-expression-circuits-for-designing-precision-tools-in-oncology
#20
REVIEW
Angela Re
Precision medicine in oncology needs to enhance its capabilities to match diagnostic and therapeutic technologies to individual patients. Synthetic biology streamlines the design and construction of functionalized devices through standardization and rational engineering of basic biological elements decoupled from their natural context. Remarkable improvements have opened the prospects for the availability of synthetic devices of enhanced mechanism clarity, robustness, sensitivity, as well as scalability and portability, which might bring new capabilities in precision cancer medicine implementations...
2017: Frontiers in Cell and Developmental Biology
journal
journal
48877
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"