journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Cell and Developmental Biology

journal
https://www.readbyqxmd.com/read/28224125/how-do-mesenchymal-stem-cells-influence-or-are-influenced-by-microenvironment-through-extracellular-vesicles-communication
#1
REVIEW
Gabriel Dostert, Benjamin Mesure, Patrick Menu, Émilie Velot
Mesenchymal stem cells (MSCs) are widely used in cell therapy and tissue engineering thanks to their self-renewal, their multipotency, and their immunomodulatory properties that make them an attractive tool for regenerative medicine. A large part of MSCs positive effects is due to their secretion products which participate in creating a favorable microenvironment and closely relate these cells to other cell types. Extracellular vesicles (EVs) belong to cellular secretions. They are produced by cells continuously or after stimulation (e...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28224124/the-mammalian-septin-interactome
#2
REVIEW
Katharina Neubauer, Barbara Zieger
Septins are GTP-binding and membrane-interacting proteins with a highly conserved domain structure involved in various cellular processes, including cytoskeleton organization, cytokinesis, and membrane dynamics. To date, 13 different septin genes have been identified in mammals (SEPT1 to SEPT12 and SEPT14), which can be classified into four distinct subgroups based on the sequence homology of their domain structure (SEPT2, SEPT3, SEPT6, and SEPT7 subgroup). The family members of these subgroups have a strong affinity for other septins and form apolar tri-, hexa-, or octameric complexes consisting of multiple septin polypeptides...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28217689/multiple-roles-of-myc-in-integrating-regulatory-networks-of-pluripotent-stem-cells
#3
REVIEW
Luca Fagnocchi, Alessio Zippo
Pluripotent stem cells (PSCs) are defined by their self-renewal potential, which permits their unlimited propagation, and their pluripotency, being able to generate cell of the three embryonic lineages. These properties render PSCs a valuable tool for both basic and medical research. To induce and stabilize the pluripotent state, complex circuitries involving signaling pathways, transcription regulators and epigenetic mechanisms converge on a core transcriptional regulatory network of PSCs, thus determining their cell identity...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28203562/editorial-antimicrobial-peptides-interaction-with-membrane-lipids-and-proteins
#4
EDITORIAL
Leendert W Hamoen, Michaela Wenzel
No abstract text is available yet for this article.
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28194397/a-novel-human-tissue-engineered-3-d-functional-vascularized-cardiac-muscle-construct
#5
Mani T Valarmathi, John W Fuseler, Jeffrey M Davis, Robert L Price
Organ tissue engineering, including cardiovascular tissues, has been an area of intense investigation. The major challenge to these approaches has been the inability to vascularize and perfuse the in vitro engineered tissue constructs. Attempts to provide oxygen and nutrients to the cells contained in the biomaterial constructs have had varying degrees of success. The aim of this current study is to develop a three-dimensional (3-D) model of vascularized cardiac tissue to examine the concurrent temporal and spatial regulation of cardiomyogenesis in the context of postnatal de novo vasculogenesis during stem cell cardiac regeneration...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28184371/transcriptional-regulation-of-telomerase-reverse-transcriptase-tert-by-myc
#6
REVIEW
Ekta Khattar, Vinay Tergaonkar
Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase reverse transcriptase (TERT), the catalytic component of telomerase. Transcription factor binding, chromatin status as well as epigenetic modifications at the TERT promoter regulates TERT transcription. Myc is an important transcriptional regulator of TERT that directly controls its expression by promoter binding and associating with other transcription factors...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28168188/diversity-of-cnidarian-muscles-function-anatomy-development-and-regeneration
#7
REVIEW
Lucas Leclère, Eric Röttinger
The ability to perform muscle contractions is one of the most important and distinctive features of eumetazoans. As the sister group to bilaterians, cnidarians (sea anemones, corals, jellyfish, and hydroids) hold an informative phylogenetic position for understanding muscle evolution. Here, we review current knowledge on muscle function, diversity, development, regeneration and evolution in cnidarians. Cnidarian muscles are involved in various activities, such as feeding, escape, locomotion and defense, in close association with the nervous system...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28154814/induced-pluripotent-stem-cells-for-traumatic-spinal-cord-injury
#8
REVIEW
Mohamad Khazaei, Christopher S Ahuja, Michael G Fehlings
Spinal cord injury (SCI) is a common cause of mortality and neurological morbidity. Although progress had been made in the last decades in medical, surgical, and rehabilitation treatments for SCI, the outcomes of these approaches are not yet ideal. The use of cell transplantation as a therapeutic strategy for the treatment of SCI is very promising. Cell therapies for the treatment of SCI are limited by several translational road blocks, including ethical concerns in relation to cell sources. The use of iPSCs is particularly attractive, given that they provide an autologous cell source and avoid the ethical and moral considerations of other stem cell sources...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28149836/turn-it-down-a-notch
#9
REVIEW
Francesca A Carrieri, Jacqueline Kim Dale
In the developing vertebrate embryo, segmentation initiates through the formation of repeated segments, or somites, on either side of the posterior neural tube along the anterior to posterior axis. The periodicity of somitogenesis is regulated by a molecular oscillator, the segmentation clock, driving cyclic gene expression in the unsegmented paraxial mesoderm, from which somites derive. Three signaling pathways underlie the molecular mechanism of the oscillator: Wnt, FGF, and Notch. In particular, Notch has been demonstrated to be an essential piece in the intricate somitogenesis regulation puzzle...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28119915/budding-yeast-an-ideal-backdrop-for-in-vivo-lipid-biochemistry
#10
REVIEW
Pushpendra Singh
Biological membranes are non-covalent assembly of lipids and proteins. Lipids play critical role in determining membrane physical properties and regulate the function of membrane associated proteins. Budding yeast Saccharomyces cerevisiae offers an exceptional advantage to understand the lipid-protein interactions since lipid metabolism and homeostasis are relatively simple and well characterized as compared to other eukaryotes. In addition, a vast array of genetic and cell biological tools are available to determine and understand the role of a particular lipid in various lipid metabolic disorders...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28119914/interleaflet-coupling-pinning-and-leaflet-asymmetry-major-players-in-plasma-membrane-nanodomain-formation
#11
REVIEW
Toyoshi Fujimoto, Ingela Parmryd
The plasma membrane has a highly asymmetric distribution of lipids and contains dynamic nanodomains many of which are liquid entities surrounded by a second, slightly different, liquid environment. Contributing to the dynamics is a continuous repartitioning of components between the two types of liquids and transient links between lipids and proteins, both to extracellular matrix and cytoplasmic components, that temporarily pin membrane constituents. This make plasma membrane nanodomains exceptionally challenging to study and much of what is known about membrane domains has been deduced from studies on model membranes at equilibrium...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28119913/sphingolipid-organization-in-the-plasma-membrane-and-the-mechanisms-that-influence-it
#12
REVIEW
Mary L Kraft
Sphingolipids are structural components in the plasma membranes of eukaryotic cells. Their metabolism produces bioactive signaling molecules that modulate fundamental cellular processes. The segregation of sphingolipids into distinct membrane domains is likely essential for cellular function. This review presents the early studies of sphingolipid distribution in the plasma membranes of mammalian cells that shaped the most popular current model of plasma membrane organization. The results of traditional imaging studies of sphingolipid distribution in stimulated and resting cells are described...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28105409/cancer-and-thrombosis-the-platelet-perspective
#13
REVIEW
Claire K S Meikle, Clare A Kelly, Priyanka Garg, Leah M Wuescher, Ramadan A Ali, Randall G Worth
Platelets are critical to hemostatic and immunological function, and are key players in cancer progression, metastasis, and cancer-related thrombosis. Platelets interact with immune cells to stimulate anti-tumor responses and can be activated by immune cells and tumor cells. Platelet activation can lead to complex interactions between platelets and tumor cells. Platelets facilitate cancer progression and metastasis by: (1) forming aggregates with tumor cells; (2) inducing tumor growth, epithelial-mesenchymal transition, and invasion; (3) shielding circulating tumor cells from immune surveillance and killing; (4) facilitating tethering and arrest of circulating tumor cells; and (5) promoting angiogenesis and tumor cell establishment at distant sites...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28101500/corrigendum-spleen-dependent-immune-protection-elicited-by-cpg-adjuvanted-reticulocyte-derived-exosomes-from-malaria-infection-is-associated-with-changes-in-t-cell-subsets-distribution
#14
Lorena Martín-Jaular, Armando de Menezes-Neto, Marta Monguió-Tortajada, Aleix Elizalde-Torrent, Míriam Díaz-Varela, Carmen Fernández-Becerra, Francesc E Borras, Maria Montoya, Hernando A Del Portillo
[This corrects the article on p. 131 in vol. 4, PMID: 27900319.].
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28101499/plasma-membrane-targeting-of-endogenous-nkcc2-in-cos7-cells-bypasses-functional-golgi-cisternae-and-complex-n-glycosylation
#15
Richa Singh, Shams Kursan, Mohamed Y Almiahoub, Mohammed M Almutairi, Tomás Garzón-Muvdi, Francisco J Alvarez-Leefmans, Mauricio Di Fulvio
Na(+)K(+)2Cl(-) co-transporters (NKCCs) effect the electroneutral movement of Na(+)-K(+) and 2Cl(-) ions across the plasma membrane of vertebrate cells. There are two known NKCC isoforms, NKCC1 (Slc12a2) and NKCC2 (Slc12a1). NKCC1 is a ubiquitously expressed transporter involved in cell volume regulation, Cl(-) homeostasis and epithelial salt secretion, whereas NKCC2 is abundantly expressed in kidney epithelial cells of the thick ascending loop of Henle, where it plays key roles in NaCl reabsorption and electrolyte homeostasis...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28083533/inactivation-of-sonic-hedgehog-signaling-and-polydactyly-in-limbs-of-hereditary-multiple-malformation-a-novel-type-of-talpid-mutant
#16
Yoshiyuki Matsubara, Mikiharu Nakano, Kazuki Kawamura, Masaoki Tsudzuki, Jun-Ichi Funahashi, Kiyokazu Agata, Yoichi Matsuda, Atsushi Kuroiwa, Takayuki Suzuki
Hereditary Multiple Malformation (HMM) is a naturally occurring, autosomal recessive, homozygous lethal mutation found in Japanese quail. Homozygote embryos (hmm(-/-)) show polydactyly similar to talpid(2) and talpid(3) mutants. Here we characterize the molecular profile of the hmm(-/-) limb bud and identify the cellular mechanisms that cause its polydactyly. The hmm(-/-) limb bud shows a severe lack of sonic hedgehog (SHH) signaling, and the autopod has 4 to 11 unidentifiable digits with syn-, poly-, and brachydactyly...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28083532/cd24-a-rheostat-that-modulates-cell-surface-receptor-signaling-of-diverse-receptors
#17
D Craig Ayre, Sherri L Christian
No abstract text is available yet for this article.
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28066767/differential-contribution-of-the-aryl-hydrocarbon-receptor-and-toll-like-receptor-pathways-to-il-8-expression-in-normal-and-cystic-fibrosis-airway-epithelial-cells-exposed-to-pseudomonas-aeruginosa
#18
Lucie Roussel, Shantelle LaFayette, Dao Nguyen, Carolyn J Baglole, Simon Rousseau
Pseudomonas aeruginosa are gram-negative bacteria that frequently infect the lungs of cystic fibrosis (CF) patients. This bacterium is highly responsive to changes in its environment, resulting in the expression of a diverse array of genes that may contribute to the host inflammatory response. P. aeruginosa is well-known to induce neutrophilic inflammation via the activation of Toll-Like Receptors (TLRs). Recently, it was shown that pyocyanin, a phenazine produced by P. aeruginosa, binds to the aryl hydrocarbon receptor (AhR), leading to neutrophilic inflammation as part of the host defense response...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28066766/editorial-molecular-mechanisms-and-physiological-significance-of-organelle-interactions-and-cooperation
#19
EDITORIAL
Michael Schrader, Markus Islinger
No abstract text is available yet for this article.
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28066765/nanotopography-induced-human-bone-marrow-mesangiogenic-progenitor-cells-mpcs-to-mesenchymal-stromal-cells-mscs-transition
#20
Sara Antonini, Marina Montali, Emanuela Jacchetti, Sandro Meucci, Paolo D Parchi, Serena Barachini, Francesca M Panvini, Simone Pacini, Iacopo Petrini, Marco Cecchini
Mesangiogenic progenitor cells (MPCs) are a very peculiar population of cells present in the human adult bone marrow, only recently discovered and characterized. Owing to their differentiation potential, MPCs can be considered progenitors for mesenchymal stromal cells (MSCs), and for this reason they potentially represent a promising cell population to apply for skeletal tissue regeneration applications. Here, we evaluate the effects of surface nanotopography on MPCs, considering the possibility that this specific physical stimulus alone can trigger MPC differentiation toward the mesenchymal lineage...
2016: Frontiers in Cell and Developmental Biology
journal
journal
48877
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"