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Journal of Clinical & Translational Endocrinology

Hala Ahmadieh, Ahmad Basho, Amal Chehade, Adeeb Al Mallah, Ahmad Dakour
Introduction: Osteoporosis is a generalized skeletal disorder characterized by decreased bone mineral density and microarchitectural deterioration, resulting in increased susceptibility to fractures. The prevalence of osteoporosis in Lebanon, defined as T-score <-2.5 at the total hip using NHANES gender-specific database was estimated to be 31% among postmenopausal women. Purpose: To assess the general perception of osteoporosis among women in Lebanon as well as their general knowledge of its lifestyle, risk factors, diagnostic, preventive and therapeutic measures...
December 2018: Journal of Clinical & Translational Endocrinology
João Martin Martins, Patrícia Aranha
Aims: To understand the paradox of an increased fracture risk despite increased bone mineral density (BMD) in persons with type 2 diabetes (DM2). Patients and Methods: We studied 80 old persons with DM2. Mineral metabolism, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), bone turnover - osteocalcin, procollagen type 1 N-terminal propeptide (P1NP) and C-terminal telopeptide of type 1 collagen (CTX) - were measured and BMD was assessed at the lumbar spine (LS) and femoral neck (FN)...
December 2018: Journal of Clinical & Translational Endocrinology
Salvatore Benvenga, Marianne Klose, Roberto Vita, Ulla Feldt-Rasmussen
Central hypothyroidism (CH) occurs approximately in 1:50,000, and therefore is expected to be one thousand times rarer compared with primary hypothyroidism. Despite its rarity in the general population, it is much more common in certain disorders, in which it is frequently associated with other pituitary hormone deficiencies. The aim of this paper is to provide an updated review on the frequency of congenital CH, which is <1:50,000, and on its etiology, disregarding CH caused by other genetic defects, such as mutations of transcription factors involved in pituitary organogenesis or mutations of the genes encoding TRH or TRH receptor...
December 2018: Journal of Clinical & Translational Endocrinology
Reem Alamoudi, Maram Alsubaiee, Ali Alqarni, Saleh Aljaser, Yousef Saleh, Abdul Salam, Mohsen Eledrisi
Objective: Fasting Ramadan is associated with changes in lifestyle patterns of patients with diabetes who choose to perform fasting. We aimed to determine the attitude and habits of patients with type 1 diabetes during fasting Ramadan. Methods: The study comprised a prospective cohort of patients with type 1 diabetes who were on insulin pump or multiple daily insulin injections (MDI) regimen. Patient questionnaires included the frequency of self-monitoring of blood glucose (SMBG), the need to make changes in insulin regimen by patients, timings of insulin administration, performing carbohydrate counting and levels of physical activity...
December 2018: Journal of Clinical & Translational Endocrinology
Jasper Sung, Suja Padmanabhan, Seema Gurung, Sally Inglis, Mauro Vicaretti, Lindy Begg, N Wah Cheung, Christian M Girgis
No abstract text is available yet for this article.
September 2018: Journal of Clinical & Translational Endocrinology
Nehal Hamdy Elsaid, Noha Adly Sadik, Nagwa Ramadan Ahmed, Sherry Elisha Fayez, Nagwa Abd El-Ghaffar Mohammed
Background: Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in type 2 diabetic obese females and assess its relation with glycemic control, insulin resistance and metabolic parameters. Methods: The study included 60 obese type 2 diabetic females and 30 healthy female subjects formed the control group...
September 2018: Journal of Clinical & Translational Endocrinology
A Catalano, D Chilà, F Bellone, G Nicocia, G Martino, I Loddo, N Morabito, S Benvenga, S Loddo
Disorders of calcium metabolism are frequently encountered in routine clinical practice. However limited data are available on the epidemiology of hypocalcemia and hypercalcemia in hospitalized patients. Our aim was to evaluate the frequency of hypocalcemia and hypercalcemia in hospitalized patients. This is a retrospective study based on the laboratory results of all hospitalized subjects (n = 12,334) whose calcemia was determined between January 1st, 2011 and December 31st, 2014. Measurements of serum calcium were carried out by a single centralized laboratory...
September 2018: Journal of Clinical & Translational Endocrinology
John Punnose, Rajeev Kumar Malhotra, Komal Sukhija, Anu Mathew, Asha Sharma, Naimaa Choudhary
Aims: Presence of bimodality in plasma glucose distribution (BPG) and its relevance for gestational diabetes mellitus (GDM) diagnosis were studied in Asian Indian pregnant women. Methods: Fasting (FPG) and two hour plasma glucose (2-h PG) values of oral glucose tolerance tests performed in 36,530 pregnant women for GDM screening (2006-16 period), were analyzed for BPG. A unimodal normal and a mixture of two normal distributions were fitted to log-transformed FPG and 2-h PG data...
September 2018: Journal of Clinical & Translational Endocrinology
Annalisa Giandalia, Maria Angela Pappalardo, Giuseppina T Russo, Elisabetta L Romeo, Angela Alibrandi, Flavia Di Bari, Roberto Vita, Domenico Cucinotta, Salvatore Benvenga
Background and objective: The Pro12Ala (exon 2) and His447His (exon 6) polymorphisms of PPAR-γ, and Gly972Arg polymorphism of IRS-1 have been implicated in insulin resistance (IR) and adiposity. Our aim was to investigate the influence of these polymorphisms on metabolic features of polycystic ovary syndrome (PCOS). Methods: Fifty-three PCOS women and 26 control women underwent a clinical and biochemical evaluation, including a 75-g oral glucose tolerance test...
September 2018: Journal of Clinical & Translational Endocrinology
Martina Blaschke, Regine Koepp, Christof Lenz, Jochen Kruppa, Klaus Jung, Heide Siggelkow
Background: Crohn's disease (CD) is associated with a higher prevalence of osteoporosis, a complication that is recognized as a significant cause of morbidity. Its pathogenesis is controversial, but the activity of CD is one contributing factor. Methods: We stimulated SCP-1 cells (mesenchymal stem cell line) under osteogenic conditions with serum from adult patients with CD in the symptomatic phase (SP) and in remission (R) and with control sera. Concentrations of IL-6, IL-1 beta, and TNF alpha in the sera were measured...
September 2018: Journal of Clinical & Translational Endocrinology
Leslie S Eldeiry, Marina M Alfisher, Catherine F Callahan, Nancy N Hanna, Jeffrey R Garber
Objective: To determine the impact of the use of an electronic medical record tool on the evaluation of adrenal incidentalomas. Methods: Retrospective chart review was used to compare rates of hormone testing and follow up imaging for adrenal incidentalomas. Patients whose radiology reports contained an algorithm with recommendations, based on our 2013 clinical guideline for the workup of these nodules, were compared to those whose imaging reports did not contain the algorithm...
September 2018: Journal of Clinical & Translational Endocrinology
Vin Tangpricha
No abstract text is available yet for this article.
June 2018: Journal of Clinical & Translational Endocrinology
Vitarani D A Ningrum, Zullies Ikawati, Ahmad H Sadewa, Mohammad R Ikhsan
Aims: This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control. Methods: The validated HPLC-UV method was used to examine metformin steady-state concentration, while FBG and glycated albumin were used as the parameters of glycemic control during metformin administration. Results: A total of 82 type-2 diabetes patients were involved with 32...
June 2018: Journal of Clinical & Translational Endocrinology
Sirikunya Torugsa, Hataikarn Nimitphong, Daruneewan Warodomwichit, La-Or Chailurkit, Kriangsuk Srijaruskul, Suwannee Chanprasertyothin, Boonsong Ongphiphadhanakul
Background: The complexity of vitamin D metabolites especially the contribution of C3-epimers of 25-hydroxyvitamin D (C3-epimers) in human sera remains unclear. We hypothesized that genetic polymorphisms in the vitamin D-related gene pathway contribute to variation in C3-epimer levels. Therefore, we investigated candidate single nucleotide polymorphisms (SNPs) concerning C3-epimer levels. Methods: The candidate SNPs, including DHCR7/NADSYN1 (rs12785878), CYP2R1 (rs2060793) and GC (rs2282679), were genotyped in 1727 members of the third project of the Electricity Generating Authority of Thailand 3/1 cohort investigation...
June 2018: Journal of Clinical & Translational Endocrinology
Soo Ting Joyce Lim, Yuen Ching Angela Hui, Pei Kwee Lim, Chin Choo Evelyn Lim, Yen Yen Chia, Rashida Farhad Vasanwala
Aim: To measure skin thickness (ST) and skin + subcutaneous layer thickness (SCT) by ultrasound and estimate the risk of intramuscular injection (IM) with different needle lengths across injection sites according to age group. Method: Children recruited between 1 and 18 years with type 1 and 2 diabetes on insulin injections and divided into three age groups: 1-6 years, 7-12 years and 13-18 years. A portable ultrasound was used to measure ST and SCT at four injection sites on the abdomen, arm, thigh and buttock...
June 2018: Journal of Clinical & Translational Endocrinology
Osama Adnan Kensara
Aims: The association between vitamin D and polycystic ovary syndrome (PCOS) is an active area of growing research. However, data in Saudi Arabia are scarce. This study aimed to define serum 25-hydroxyvitamin D (25(OH)D) levels among Saudi women with naïve PCOS, and to investigate the associations of their 25(OH)D status with their serum adiponectin and follistatin levels, along with indices of insulin resistance and hormonal deteriorations. Methods: In this case-control observational study, 63 women with PCOS and 65 age-and body mass index (BMI)-matched control women were assessed...
June 2018: Journal of Clinical & Translational Endocrinology
Usha Sethuraman, Marwan A Zidan, Lynae Hanks, Minoo Bagheri, Ambika Ashraf
Background: Obesity is affecting children in epidemic proportions in the United States with nearly 25% of children being obese. Consequences of obesity including dyslipidemia, type 2 diabetes and cardiovascular disease are leading to morbidity at younger ages. Parallel to the obesity and diabetes epidemics, the prevalence of vitamin D deficiency has reached very high levels and has been associated with insulin resistance and dyslipidemia. Studies exploring the impact of vitamin D repletion on insulin sensitivity and dyslipidemia in children are sparse...
June 2018: Journal of Clinical & Translational Endocrinology
Diana Cristina Henao-Carrillo, Oscar M Muñoz, Ana M Gómez, Martín Rondón, Christian Colón, L Chica, Claudia Rubio, Fabián León-Vargas, Maria Alejandra Calvachi, Ana María Perea
Introduction: Degludec (IDeg) is an ultralong-acting insulin, with stable pharmacodynamic profile which leads to lower fluctuations in glucose levels. The effect of IDeg has not been specifically assessed in patients with unstable diabetes, defined as increased glycemic variability (GV). Methods: A prospective before-after pilot study was conducted, including patients managed at Hospital Universitario San Ignacio in Bogotá, Colombia. The impact of the switch from a Glargine or Detemir insulin to a basal insulin regimen with IDeg for 12 weeks on GV measured by continuous glucose monitoring, on A1c levels, and on the incidence of episodes of global and nocturnal hypoglycemia was assessed in a group of patients with (coefficient of variation >34%) or without increased basal GV using a Generalised Estimating Equation (GEE) analysis...
June 2018: Journal of Clinical & Translational Endocrinology
Sheela N Magge, Divya Prasad, Babette S Zemel, Andrea Kelly
Objectives: Obese, African-American (AA) adolescents are at increased risk for vitamin D deficiency. The primary objective of this pilot study was to examine the effect of vitamin D supplementation upon 25-hydroxy vitamin D (25OHD) levels in obese, AA adolescents. Methods: A randomized, double-blinded, controlled pilot study included 26 obese (BMI ≥ 95%ile), vitamin D deficient (25OHD < 20 ng/mL), pubertal AA adolescents (ages 12-17). Subjects received cholecalciferol 1000 IU or 5000 IU daily for 3 months...
June 2018: Journal of Clinical & Translational Endocrinology
Salvatore Benvenga, Flavia Di Bari, Roberta Granese, Irene Borrielli, Grazia Giorgianni, Loredana Grasso, Maria Le Donne, Roberto Vita, Alessandro Antonelli
After encountering two women with serum thyrotropin (TSH) levels greater in periovulatory phase than in other days of the menstrual cycle, we hypothesized that TSH levels could be sensitive to changes in circulating estrogens in women. The objective of this study was to evaluate whether serum TSH increases after an induced acute increase of serum estradiol, and compare serum TSH increase with that of prolactin (PRL) which is a classic estradiol-upregulated pituitary hormone. In this retrospective study, we resorted to stored frozen sera from 55 women who had undergone the GnRH agonist (buserelin)-acute stimulation test of ovarian steroidogenesis...
March 2018: Journal of Clinical & Translational Endocrinology
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