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Journal of Clinical & Translational Endocrinology

Fausto Fama', Roberto Vita, Alessandro Sindoni, Sergio Lucio Vinci, Grazia Giorgianni, Loredana Grasso, Maria Gioffre'-Florio, Salvatore Benvenga
One-hundred four persons aged ≥ 18 years (62 males and 42 females) who were admitted for traumatic brain injury (TBI) underwent brain computed tomography (CT) scan and assay of serum cortisol, insulin-like growth factor 1 (IGF-1), thyrotropin (TSH) and free thyroxine (FT4). The main purpose was to assess any gender difference and the rate of empty sella (ES). Women were more likely to have empty sella (19/42 [45.2%] vs 19/62 [30.6%], P = 0.15, OR = 1.9), which was more frequently total ES or TES (16/19 [84...
March 2019: Journal of Clinical & Translational Endocrinology
María M Adeva-Andany, Raquel Funcasta-Calderón, Carlos Fernández-Fernández, Elvira Castro-Quintela, Natalia Carneiro-Freire
Diabetes is a common metabolic disorder that involves glucose, amino acids, and fatty acids. Either insulin deficiency or insulin resistance may cause diabetes. Insulin deficiency causes type 1 diabetes and diabetes associated with total pancreatectomy. Glucagon produces insulin resistance. Glucagon-induced insulin resistance promotes type 2 diabetes and diabetes associated with glucagonoma. Further, glucagon-induced insulin resistance aggravates the metabolic consequences of the insulin-deficient state. A major metabolic effect of insulin is the accumulation of glucose as glycogen in the liver...
March 2019: Journal of Clinical & Translational Endocrinology
Norikazu Toi, Masaaki Inaba, Masafumi Kurajoh, Tomoaki Morioka, Noriyuki Hayashi, Tomoe Hirota, Daichi Miyaoka, Masanori Emoto, Shinsuke Yamada
Introduction: Acute and chronic insomnia can exacerbate type 2 diabetes mellitus (T2DM). We investigated suvorexant (an anti-insomnia drug that targets the orexin system) effects on sleep architecture and glucose metabolism in T2DM patients with insomnia. Materials and methods: This 7 day open-label, single-arm, intervention trial included 18 subjects with T2DM and insomnia. After 1 day acclimatization, daily glucose levels, sleep architecture, and autonomic nervous function were evaluated by continuous glucose monitoring (CGM), single-channel electroencephalography, and accelerometry, respectively...
March 2019: Journal of Clinical & Translational Endocrinology
Mohsen Eledrisi, Noor Nabeel Suleiman, Obada Salameh, Mohammad Khair Hamad, Omar Rabadi, Ahmed Mohamed, Rana Al Adawi, Abdul Salam
No abstract text is available yet for this article.
March 2019: Journal of Clinical & Translational Endocrinology
Hala Ibrahim El Gendy, Noha Adly Sadik, Mona Youssry Helmy, Laila Ahmed Rashed
Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control. Methods: 50 patients with T2DM and 50 healthy age matched control subjects were enrolled...
March 2019: Journal of Clinical & Translational Endocrinology
Rahul Peravali, Lucas Gunnels, Satyanarayana Alleboina, Ivan C Gerling, Ayotunde O Dokun
Peripheral Artery Disease (PAD) is a chronic, activity-limiting disease that is caused by atherosclerotic occlusion of blood vessels outside the heart. Type 1 Diabetes (T1D) not only increases an individual's likelihood of developing PAD, but also contributes to poor clinical outcomes after PAD manifestation. Although there is some evidence suggesting that hyperglycemia might alter expression of genes involved in regulating PAD severity or outcomes, our knowledge about the specific genes and pathways involved remains incomplete...
March 2019: Journal of Clinical & Translational Endocrinology
Salvatore Benvenga, Flavia Di Bari, Roberto Vita, Maria Le Donne, Onofrio Triolo, Roberta Granese, Irene Borrielli, Giuseppe Sole, Marco Floridia, Filippo Genovesi, Domitilla Tromba, Domenico Tromba
The prevalence of postpartum thyroiditis (PPT) averages 5%, with a range from 1% (Thailand) to 22% (Wales, UK, and Liguria, Italy), but 3.6% in another Italian region (Puglia). Evolution of PPT into permanent hypothyroidism (PH) occurs in approximately 50% of cases. Positive thyroperoxidase autoantibodies (TPOAb) in a pregnant woman is a strong predictor of PPT. Because in previous gestational cohorts we found an approximate 12% rate of TPOAb positivity, which compares with 15% in the Liguria cohort and 6% in the Puglia cohort, we hypothesized that the currently unknown prevalence of PPT in Sicily would approximate the said Liguria prevalence...
March 2019: Journal of Clinical & Translational Endocrinology
James Heath Pelham, Lynae Hanks, Stella Aslibekyan, Shima Dowla, Ambika P Ashraf
Aim: Significant knowledge gaps exist regarding lipoprotein profiles in children with type 2 diabetes mellitus (T2DM). The primary objective was to analyze the type and nature of lipoprotein abnormalities present in children with T2DM and to identify determinants of adverse lipoprotein profiles. The secondary objective was to assess associations with elevated glycated hemoglobin (HbA1C), i.e., <8% vs. ≥8.0% and pediatric dyslipidemias in the setting of T2DM. Methods: This retrospective chart review included children with T2DM who had undergone lipoprotein analysis and were not on lipid lowering medications (n = 93)...
March 2019: Journal of Clinical & Translational Endocrinology
Le Zhou, Gianlorenzo Dionigi, Alessandro Pontin, Antonella Pino, Ettore Caruso, Che-Wei Wu, Hui Sun, Ralph P Tufano, Hoon Yub Kim
We evaluate the role of intraoperative neuromonitoring (IONM) in thyroidectomy performed for Graves' disease (GD) with an emphasis on recurrent laryngeal nerve (RLN) management and completeness of resection. The study is a retrospective series comprising 55 thyroidectomy (control group) versus 82 procedures with intermittent IONM (I-IONM) and 72 by means of continuous IONM (C-IONM). In the control group the laryngeal nerves have been identified by visualization solely. In the I-IONM group both vagal nerve (VN) and RLN have been localized and monitored during thyroid resection...
March 2019: Journal of Clinical & Translational Endocrinology
Leonid N Maslov, Natalia V Naryzhnaya, Alla A Boshchenko, Sergey V Popov, Vladimir V Ivanov, Peter R Oeltgen
Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of leptin, MCP-1, IL-6, and TNF-α by adipocytes. It was established that oxidative stress induces a decrease in adiponectin production by adipocytes. It has also been shown that obesity itself can induce oxidative stress...
March 2019: Journal of Clinical & Translational Endocrinology
Salvatore Arena, Salvatore Benvenga
No data are available on the cytologically and histologically demonstrated presence of intranodular chronic lymphocytic thyroiditis (ICLT) and on the ICLT relationship with thyroid nodule characteristics such as size, echotexture and nature (benign or malignant). We wished to fill this gap by analyzing data in a gender-specific fashion. We studied 408 thyroid nodules from 408 consecutive persons (325 females and 83 males). Nodules were isoechoic (n = 268) or hypoechoic (n = 140), ICLT +ve (n = 113 [27...
December 2018: Journal of Clinical & Translational Endocrinology
Thorsten Siegmund, Anja Borck, Ariel Zisman, Peter Bramlage, Stephan Kress
Aims: The BeAM value refers to the difference between a patient's blood glucose level at bedtime (Be) and the following morning before breakfast (AM). The clinical impact of a negative BeAM value (AM blood glucose reading compared to that taken at bedtime) is unknown. Methods: T2DM patients of the OPAL and POC trials were pooled and their BeAM values calculated. Results: From a total of 358 patients, 31 were calculated as having a negative BeAM value at baseline, while 182 had a high value...
December 2018: Journal of Clinical & Translational Endocrinology
Salvatore Benvenga, Marianne Klose, Roberto Vita, Ulla Feldt-Rasmussen
Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion...
December 2018: Journal of Clinical & Translational Endocrinology
Hala Ahmadieh, Ahmad Basho, Amal Chehade, Adeeb Al Mallah, Ahmad Dakour
Introduction: Osteoporosis is a generalized skeletal disorder characterized by decreased bone mineral density and microarchitectural deterioration, resulting in increased susceptibility to fractures. The prevalence of osteoporosis in Lebanon, defined as T-score <-2.5 at the total hip using NHANES gender-specific database was estimated to be 31% among postmenopausal women. Purpose: To assess the general perception of osteoporosis among women in Lebanon as well as their general knowledge of its lifestyle, risk factors, diagnostic, preventive and therapeutic measures...
December 2018: Journal of Clinical & Translational Endocrinology
João Martin Martins, Patrícia Aranha
Aims: To understand the paradox of an increased fracture risk despite increased bone mineral density (BMD) in persons with type 2 diabetes (DM2). Patients and Methods: We studied 80 old persons with DM2. Mineral metabolism, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), bone turnover - osteocalcin, procollagen type 1 N-terminal propeptide (P1NP) and C-terminal telopeptide of type 1 collagen (CTX) - were measured and BMD was assessed at the lumbar spine (LS) and femoral neck (FN)...
December 2018: Journal of Clinical & Translational Endocrinology
Salvatore Benvenga, Marianne Klose, Roberto Vita, Ulla Feldt-Rasmussen
Central hypothyroidism (CH) occurs approximately in 1:50,000, and therefore is expected to be one thousand times rarer compared with primary hypothyroidism. Despite its rarity in the general population, it is much more common in certain disorders, in which it is frequently associated with other pituitary hormone deficiencies. The aim of this paper is to provide an updated review on the frequency of congenital CH, which is <1:50,000, and on its etiology, disregarding CH caused by other genetic defects, such as mutations of transcription factors involved in pituitary organogenesis or mutations of the genes encoding TRH or TRH receptor...
December 2018: Journal of Clinical & Translational Endocrinology
Reem Alamoudi, Maram Alsubaiee, Ali Alqarni, Saleh Aljaser, Yousef Saleh, Abdul Salam, Mohsen Eledrisi
Objective: Fasting Ramadan is associated with changes in lifestyle patterns of patients with diabetes who choose to perform fasting. We aimed to determine the attitude and habits of patients with type 1 diabetes during fasting Ramadan. Methods: The study comprised a prospective cohort of patients with type 1 diabetes who were on insulin pump or multiple daily insulin injections (MDI) regimen. Patient questionnaires included the frequency of self-monitoring of blood glucose (SMBG), the need to make changes in insulin regimen by patients, timings of insulin administration, performing carbohydrate counting and levels of physical activity...
December 2018: Journal of Clinical & Translational Endocrinology
Jasper Sung, Suja Padmanabhan, Seema Gurung, Sally Inglis, Mauro Vicaretti, Lindy Begg, N Wah Cheung, Christian M Girgis
No abstract text is available yet for this article.
September 2018: Journal of Clinical & Translational Endocrinology
Nehal Hamdy Elsaid, Noha Adly Sadik, Nagwa Ramadan Ahmed, Sherry Elisha Fayez, Nagwa Abd El-Ghaffar Mohammed
Background: Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in type 2 diabetic obese females and assess its relation with glycemic control, insulin resistance and metabolic parameters. Methods: The study included 60 obese type 2 diabetic females and 30 healthy female subjects formed the control group...
September 2018: Journal of Clinical & Translational Endocrinology
A Catalano, D Chilà, F Bellone, G Nicocia, G Martino, I Loddo, N Morabito, S Benvenga, S Loddo
Disorders of calcium metabolism are frequently encountered in routine clinical practice. However limited data are available on the epidemiology of hypocalcemia and hypercalcemia in hospitalized patients. Our aim was to evaluate the frequency of hypocalcemia and hypercalcemia in hospitalized patients. This is a retrospective study based on the laboratory results of all hospitalized subjects (n = 12,334) whose calcemia was determined between January 1st, 2011 and December 31st, 2014. Measurements of serum calcium were carried out by a single centralized laboratory...
September 2018: Journal of Clinical & Translational Endocrinology
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