Vishnubhotla Ravikanth, Mitnala Sasikala, Vankadari Naveen, Sabbu Sai Latha, Kishore Venkata Laxmi Parsa, Ketavarapu Vijayasarathy, Ramars Amanchy, Steffie Avanthi, Bale Govardhan, Kalapala Rakesh, Daram Sarala Kumari, Bojja Srikaran, Guduru Venkat Rao, D Nageshwar Reddy
Background: Mortality due to COVID-19 caused by SARS-CoV-2 infection varies among populations. Functional relevance of genetic variations in Angiotensin-converting enzyme 2 ( ACE2 ) and Transmembrane serine protease 2 ( TMPRSS2 ), two crucial host factors for viral entry, might explain some of this variation. Methods: In this comparative study in Indian subjects, we recruited 510 COVID-19 patients and retrieved DNA from 520 controls from a repository. Associations between variants in ACE2 and TMPRSS2 with disease severity were identified by whole exome sequencing (WES, n = 20) and targeted genotyping ( n = 1010)...
May 28, 2021: Meta Gene