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SAGE Open Medicine

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https://www.readbyqxmd.com/read/28382208/etravirine-combined-with-antiretrovirals-other-than-darunavir-ritonavir-for-hiv-1-infected-treatment-experienced-adults-week-48-results-of-a-phase-iv-trial
#1
Eduardo Arathoon, Asad Bhorat, Rodica Silaghi, Herta Crauwels, Ludo Lavreys, Lotke Tambuyzer, Ben Van Baelen, Simon Vanveggel, Magda Opsomer
OBJECTIVE: VIOLIN (TMC125IFD3002; NCT01422330) evaluated the safety, tolerability, and pharmacokinetics of etravirine with antiretrovirals other than darunavir/ritonavir in HIV-1-infected patients. METHODS: In a 48-week, phase IV, single-arm, multicenter study, patients on prior antiretroviral therapy (⩾8 weeks) who needed to change regimen for virologic failure (viral load ⩾ 500 copies/mL) or simplification/adverse events (viral load < 50 copies/mL) received etravirine 200 mg bid with ⩾1 other active antiretroviral, excluding darunavir/ritonavir or only nucleoside/tide reverse transcriptase inhibitors...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28344784/effects-of-tamsulosin-and-tolterodine-on-double-j-stent-related-symptoms-a-double-blind-randomized-placebo-controlled-trial
#2
Mahmoudreza Moradi, Hossein Abdi, Sina Ebrahimi, Haress Rezaee, Kaveh Kaseb
BACKGROUND: Ureteral double J stent are routinely applied for urologic patients although stent-related symptoms are common. Several attempts have been reported to minimize these symptoms. OBJECTIVE: To compare Tolterodine, Tamsulosin, and placebo effects on double J stent-related symptoms. MATERIAL AND METHOD: In all, 125 patients (82 males and 43 females) with double J stent were randomly divided into three groups (group 1, n: 42, group2, n: 40 and group 3, n: 43)...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28321303/comparative-study-on-treatment-satisfaction-and-health-perception-in-children-and-adolescents-with-type-1-diabetes-mellitus-on-multiple-daily-injection-of-insulin-insulin-pump-and-sensor-augmented-pump-therapy
#3
Tara Hussain, Mariette Akle, Nico Nagelkerke, Asma Deeb
OBJECTIVES: Diabetes management imposes considerable demands on patients. Treatment method used has an impact on treatment satisfaction. We aim to examine the relationship between treatment satisfaction and health perception with the method used for treatment of type 1 diabetes mellitus in children and adolescents. SUBJECTS AND METHOD: We have interviewed patients with type 1 diabetes mellitus using questionnaires to assess treatment satisfaction and health perception...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28293423/growth-inhibitory-activity-of-ankaferd-hemostat-on-primary-melanoma-cells-and-cell-lines
#4
Seyhan Turk, Umit Yavuz Malkan, Mehdi Ghasemi, Helin Hocaoglu, Duygu Mutlu, Gursel Gunes, Salih Aksu, Ibrahim Celalettin Haznedaroglu
OBJECTIVE: Ankaferd hemostat is the first topical hemostatic agent about the red blood cell-fibrinogen relations tested in the clinical trials. Ankaferd hemostat consists of standardized plant extracts including Alpinia officinarum, Glycyrrhiza glabra, Thymus vulgaris, Urtica dioica, and Vitis vinifera. The aim of this study was to determine the effect of Ankaferd hemostat on viability of melanoma cell lines. METHODS: Dissimilar melanoma cell lines and primary cells were used in this study...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28255442/validity-and-test-retest-reliability-of-a-novel-simple-back-extensor-muscle-strength-test
#5
Amy T Harding, Benjamin Kurt Weeks, Sean A Horan, Andrew Little, Steven L Watson, Belinda Ruth Beck
OBJECTIVES: To develop and determine convergent validity and reliability of a simple and inexpensive clinical test to quantify back extensor muscle strength. METHODS: Two testing sessions were conducted, 7 days apart. Each session involved three trials of standing maximal isometric back extensor muscle strength using both the novel test and isokinetic dynamometry. Lumbar spine bone mineral density was examined by dual-energy X-ray absorptiometry. Validation was examined with Pearson correlations (r)...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28228952/assessment-of-the-expectancy-seriousness-and-severity-of-adverse-drug-reactions-reported-for-chronic-obstructive-pulmonary-disease-therapy
#6
Guenka Petrova, Assena Stoimenova, Maria Dimitrova, Maria Kamusheva, Daniela Petrova, Ognian Georgiev
INTRODUCTION: Adverse drug reactions can cause increased morbidity and mortality, and therefore information needs to be studied systematically. Little is known about the adverse drug reactions for chronic obstructive pulmonary disease therapy. The goal of this study is to assess the expectedness, seriousness and severity of adverse drug reactions during chronic obstructive pulmonary disease therapy based on their reporting in the national pharmacovigilance system. METHODS: This was a prospective, observational, 1-year, real-life study about the pharmacotherapy of a sample of 390 chronic obstructive pulmonary disease patients...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28228951/are-we-cross-matching-too-much-blood-for-elective-open-abdominal-aortic-aneurysm-repair
#7
Emily Lowe, John Quarmby
OBJECTIVES: This study aims to identify current blood transfusion requirements in elective open abdominal aortic aneurysm repair and to compare this to an existing maximum surgical blood order schedule. METHODS: We retrospectively identified patients who underwent elective open abdominal aortic aneurysm repair over a 40-month period in our institution. Pre-operative number of units cross-matched and the number of units actually transfused were identified. The cross-match to transfusion ratio was then calculated...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28228950/outcomes-of-coronary-artery-bypass-grafting-versus-percutaneous-coronary-intervention-with-second-generation-drug-eluting-stents-for-patients-with-multivessel-and-unprotected-left-main-coronary-artery-disease
#8
Kyriacos Papadopoulos, Ioannis Lekakis, Evagoras Nicolaides
OBJECTIVES: To compare the efficacy and safety of percutaneous coronary intervention using second-generation drug-eluting stents with those of coronary artery bypass grafting among patients with multivessel disease and/or unprotected left main coronary artery disease in terms of mortality, myocardial infarction, repeat revascularization, and angina. BACKGROUND: Although coronary artery disease is a leading cause of death in the Western world and in many developing countries, its optimal treatment is still a matter of controversy...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28228949/engaging-patients-as-partners-in-research-factors-associated-with-awareness-interest-and-engagement-as-research-partners
#9
Kristine R Hearld, Larry R Hearld, Allyson G Hall
OBJECTIVES: There is growing interest in engaging patients in healthcare research, which raises important questions about the factors that may promote such engagement. The purpose of this study was to examine the association between patient characteristics and three aspects of patient engagement in the medical research process: awareness, interest, and actual participation. METHODS: Cross-sectional, bivariate analyses were employed using the 2014 Health Information National Trends Survey...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28228948/health-system-frameworks-and-performance-indicators-in-eight-countries-a-comparative-international-analysis
#10
Jeffrey Braithwaite, Peter Hibbert, Brette Blakely, Jennifer Plumb, Natalie Hannaford, Janet Cameron Long, Danielle Marks
OBJECTIVES: Performance indicators are a popular mechanism for measuring the quality of healthcare to facilitate both quality improvement and systems management. Few studies make comparative assessments of different countries' performance indicator frameworks. This study identifies and compares frameworks and performance indicators used in selected Organisation for Economic Co-operation and Development health systems to measure and report on the performance of healthcare organisations and local health systems...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28228947/a-randomized-clinical-trial-of-diabetes-self-management-for-mexican-americans-are-there-serendipitous-health-benefits-for-supporters-of-study-participants
#11
Sharon A Brown, Alexandra A García, Philip R Orlander, Craig L Hanis
OBJECTIVES: Studies of social support in diabetes have focused on the effects of support on the person with type 2 diabetes. We explored diabetes prevention effects of a culturally tailored diabetes self-management intervention in individuals without diabetes who were supporters of intervention participants. METHODS: This is a secondary analysis of data from a randomized clinical trial that involved 256 Mexican Americans with diabetes. Each study participant designated a supporter-spouse, relative, friend-who attended intervention sessions and assisted participants in attaining effective diabetes self-management...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348743/management-of-upper-ureteral-stones-exceeding-15-mm-in-diameter-shock-wave-lithotripsy-versus-semirigid-ureteroscopy-with-holmium-yttrium-aluminum-garnet-laser-lithotripsy
#12
Hamdy Aboutaleb, Mohamed Omar, Shady Salem, Mohamed Elshazly
OBJECTIVES: We conducted a retrospective study to evaluate the efficacy and outcome of shock wave lithotripsy versus semirigid ureteroscopy in the management of the proximal ureteral stones of diameter exceeding 15 mm. METHODS: During the 2009-2014 study period, 147 patients presenting with the proximal ureteral stones exceeding 15 mm in diameter were treated. Both shock wave lithotripsy and ureteroscopy with laser lithotripsy were offered for our patients. A 6/8...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348742/risk-factors-for-clostridium-difficile-infection-in-hiv-infected-patients
#13
Hannah Imlay, Daniel Kaul, Krishna Rao
BACKGROUND: Clostridium difficile infection is a healthcare-associated infection resulting in significant morbidity. Although immunosuppression is associated with Clostridium difficile infection acquisition and adverse outcomes, the epidemiology of Clostridium difficile infection in HIV-infected patients has been little studied in the era of antiretroviral therapy. This study identifies the risk factors for acquisition of Clostridium difficile infection in HIV-infected patients. METHODS: A retrospective, propensity score-matched case-control study design was employed, with patients selected from our institution's outpatient HIV clinic...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348741/fructose-toxic-effect-on-cardiorenal-risk-factors-and-redox-state
#14
Fabiane V Francisqueti, Klinsmann C Santos, Artur Jt Ferron, Angelo Tc Lo, Igor O Minatel, Dijon Hs Campos, Ana Lucia A Ferreira, Camila R Corrêa
AIM: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. METHODS: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348740/type-2-diabetes-mellitus-is-associated-with-increased-risk-of-pancreatic-cancer-a-veteran-administration-registry-study
#15
Issam Makhoul, Abdulraheem Yacoub, Eric Siegel
BACKGROUND: The etiology of pancreatic cancer remains elusive. Several studies have suggested a role for diabetes mellitus, but the magnitude of its contribution remains controversial. OBJECTIVES: Utilizing a large administrative database, this retrospective cohort study was designed to investigate the relationship between type 2 diabetes mellitus and pancreatic cancer. PATIENTS AND DESIGN: Using the Veterans Integrated Services Network 16 database, 322,614 subjects were enrolled in the study, including 110,919 with type 2 diabetes mellitus and 211,695 diabetes-free controls matched by gender, year of birth and healthcare facility...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348739/effectiveness-of-an-early-mobilization-program-on-functional-capacity-after-coronary-artery-bypass-surgery-a-randomized-controlled-trial-protocol
#16
Daniel da Costa Torres, Priscila Maria Ramos Dos Santos, Helder José Lima Reis, Denise Moraes Paisani, Luciana Dias Chiavegato
BACKGROUND: Muscle atrophy and prolonged inactivity are associated with an increased sensation of fatigue and reduced functional capacity in the postoperative period in patients undergoing coronary artery bypass grafting. Cardiac rehabilitation after hospital discharge is highly recommended and contributes to improvement in functional capacity and quality of life. However, few studies have evaluated the effectiveness of early mobilization protocols during hospitalization on the patterns of physical activity and functional capacity after coronary artery bypass grafting...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348738/use-of-selective-serotonin-reuptake-inhibitors-and-platelet-aggregation-inhibitors-among-individuals-with-co-occurring-atherosclerotic-cardiovascular-disease-and-depression-or-anxiety
#17
J Douglas Thornton, Parul Agarwal, Usha Sambamoorthi
OBJECTIVE: Medications commonly used to treat heart disease, anxiety, and depression can interact resulting in an increased risk of bleeding, warranting a cautious approach in medical decision making. This retrospective, descriptive study examined the prevalence and the factors associated with the use of both selective-serotonin reuptake inhibitor and platelet aggregation inhibitor among individuals with co-occurring atherosclerotic cardiovascular disease and anxiety or depression. METHODS: Respondents aged 22 years and older, alive throughout the study period, and diagnosed with co-occurring atherosclerotic cardiovascular disease and anxiety or depression (n = 1507) in years 2007 through 2013 of the Medical Expenditures Panel Survey were included...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348737/performance-of-a-cognitive-load-inventory-during-simulated-handoffs-evidence-for-validity
#18
John Q Young, Christy K Boscardin, Savannah M van Dijk, Ruqayyah Abdullah, David M Irby, Justin L Sewell, Olle Ten Cate, Patricia S O'Sullivan
BACKGROUND: Advancing patient safety during handoffs remains a public health priority. The application of cognitive load theory offers promise, but is currently limited by the inability to measure cognitive load types. OBJECTIVE: To develop and collect validity evidence for a revised self-report inventory that measures cognitive load types during a handoff. METHODS: Based on prior published work, input from experts in cognitive load theory and handoffs, and a think-aloud exercise with residents, a revised Cognitive Load Inventory for Handoffs was developed...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348736/effect-of-high-intensity-training-on-endothelial-function-in-patients-with-cardiovascular-and-cerebrovascular-disease-a-systematic-review
#19
Mia Kolmos, Rikke Steen Krawcyk, Christina Kruuse
OBJECTIVES: Exercise improves endothelial dysfunction, the key manifestation of cardiovascular and cerebrovascular disease, and is recommended in both cardiovascular and cerebrovascular rehabilitation. Disagreement remains, however, on the role of intensity of exercise. The purpose of this review was to gather current knowledge on the effects of high-intensity training versus moderate-intensity continuous exercise on endothelial function in cardiovascular and cerebrovascular patients...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/28348735/a-multimodal-approach-to-improving-human-papillomavirus-vaccination-in-a-community-pharmacy-setting
#20
Kenneth C Hohmeier, Donna D Randolph, Cindy Taliaferro Smith, Tracy M Hagemann
BACKGROUND: Community pharmacy has become a major access point for several types of vaccinations. Despite the success of vaccination programs like influenza, pneumococcal, and herpes zoster, the rates of human papillomavirus vaccination continue to lag. OBJECTIVES: The primary objective is to describe and report on the impact of a multimodal series of pharmacist-led educational interventions on human papillomavirus vaccination rates in a community pharmacy setting...
2016: SAGE Open Medicine
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