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SAGE Open Medicine

Lealem Gedefaw Bimerew, Tesfaye Demie, Kaleab Eskinder, Aklilu Getachew, Shiferaw Bekele, Waqtola Cheneke, Zewdineh Sahlemariam, Wondimagegn Adisu, Yaregal Asres, Tilahun Yemane, Girum Tesfaye, Getnet Tesfaw, Esayas Kebede Gudina, Zeleke Mekonnen
Background: Clinical laboratory reference intervals are an important tool to identify abnormal laboratory test results. The generating of hematological parameters reference intervals for local population is very crucial to improve quality of health care, which otherwise may lead to unnecessary expenditure or denying care for the needy. There are no well-established reference intervals for hematological parameters in southwest Ethiopia. Objective: To generate hematological parameters reference intervals for apparently healthy individuals in southwest Ethiopia...
2018: SAGE Open Medicine
David C Reardon
The abortion and mental health controversy is driven by two different perspectives regarding how best to interpret accepted facts. When interpreting the data, abortion and mental health proponents are inclined to emphasize risks associated with abortion, whereas abortion and mental health minimalists emphasize pre-existing risk factors as the primary explanation for the correlations with more negative outcomes. Still, both sides agree that (a) abortion is consistently associated with elevated rates of mental illness compared to women without a history of abortion; (b) the abortion experience directly contributes to mental health problems for at least some women; (c) there are risk factors, such as pre-existing mental illness, that identify women at greatest risk of mental health problems after an abortion; and (d) it is impossible to conduct research in this field in a manner that can definitively identify the extent to which any mental illnesses following abortion can be reliably attributed to abortion in and of itself...
2018: SAGE Open Medicine
Pernille Ravn Jakobsen, Anne Pernille Hermann, Jens Søndergaard, Uffe Kock Wiil, Jane Clemensen
Objectives: This study aims to test a mobile health application (mHealth app) developed to meet the needs of women newly diagnosed with asymptomatic osteoporosis. We investigate how the women experience using an mHealth app upon diagnosis of osteoporosis and whether the app can help them to be prepared for treatment decision-making and support them in osteoporosis self-management. We also tested the usability of the app, to find out whether any adjustments were necessary prior to implementation...
2018: SAGE Open Medicine
John Spencer Ingels, Adam Hansell, Sam Zizzi
Objectives: Previous research with participants in weight management has primarily focused on participant weight-loss expectations. The purpose of this study was to explore participant expectations and strategies for measuring progress during a community-based weight management program. Methods: Semi-structured interviews were completed with 22 participants with overweight or obesity, who were currently enrolled in a 2-year weight management program in order to understand their expectations and strategies for measuring their progress...
2018: SAGE Open Medicine
Ajinkya M Pawar, Kerry L LaPlante, Tristan T Timbrook, Aisling R Caffrey
Objectives: Varying statin exposures in bacteremic patients have different impacts on mortality. Among patients with adherent statin use, we sought to evaluate the impact of statin continuation on inpatient mortality in bacteremic patients. Methods: A retrospective cohort study was conducted using Optum ClinformaticsTM with matched Premier Hospital data (October 2009-March 2013). Patients with a primary diagnosis of bacteremia and 6 months of continuous enrollment prior to the admission, receiving antibiotics at least 2 days of antibiotics during the first 3 days of admission, were selected for inclusion...
2018: SAGE Open Medicine
Michael Zhang, David F Jativa
Background: Low plasma levels of vitamin C are associated with adverse outcomes, including increased mortality, in critically ill patients. Several trials have suggested that the administration of intravenous vitamin C in this setting may have beneficial effects, such as reducing the incidence of organ failure and improving survival. However, these studies have generally involved combination therapies consisting of vitamin C along with other antioxidants, confounding the effects of vitamin C alone...
2018: SAGE Open Medicine
Joseph D Tariman, Pamela Katz, Jessica Bishop-Royse, Lisa Hartle, Katharine L Szubski, Toreend Enecio, Ima Garcia, Nadia Spawn, Katherine Jones Masterton
Objectives: This study aimed to develop a scale that can measure the role competency of oncology nurses during shared decision-making process. Methods: A total of 226 oncology nurses who actively provide direct care to patients from inpatient and outpatient oncology units in the Midwest and Pacific Northwest completed the online or mail survey. Exploratory factor analysis and parallel analysis showed the multidimensionality of the role competency scale on shared decision-making nurses...
2018: SAGE Open Medicine
Ming-Ming Yan, Shu-Shan Wu, Yin-Qing Ying, Nan Lu, Ming-Kang Zhong
Objectives: Acute muscle injury and potentially fatal rhabdomyolysis may occur with the use of statins and certain enzyme inhibitors, but data on this topic from China are quite limited. This study aimed to measure the concomitant exposure of patients to different statins and their enzyme inhibitors or interacting medications in 76 hospitals in six Chinese cities. Methods: Prescription database was retrieved from Hospital Prescription Analysis Cooperation Project from January 2015 to December 2015, covering 76 tertiary facilities in six cities in China...
2018: SAGE Open Medicine
Xavier Debussche, Victorine Lenclume, Maryvette Balcou-Debussche, Danielle Alakian, Claude Sokolowsky, Delphine Ballet, Gerald R Elsworth, Richard H Osborne, Laetitia Huiart
Objectives: Health literacy refers to the ability of individuals to gain access to, use, and understand health information and services in order to maintain a good health. The assessment of health literacy profiles in a population is potentially crucial to respond to health needs. The Health Literacy Questionnaire explores nine dimensions of health literacy and has been shown to display robust psychometric properties. The aim was to test the validity of the multidimensional Health Literacy Questionnaire and to describe the health literacy profiles in a French population at risk of cardiovascular disease...
2018: SAGE Open Medicine
Ingrid Arevalo-Rodriguez, Edgar Muñoz, Diana Buitrago-Garcia, Solange Nuñez-González, Nadia Montero-Oleas, Vanessa Garzón, Hector Pardo-Hernandez, Xavier Bonfill
Few Orthopaedics and Traumatology journals from Latin America and Spain are indexed in major databases; controlled clinical trials published in these journals cannot be exhaustively retrieved using electronic literature searches. We aimed to identify, describe and assess the quality of controlled clinical trials published in Orthopaedics and Traumatology journals from Latin America and Spain through handsearching and evidence mapping methods. We identified controlled clinical trials published in eligible Orthopaedics/Traumatology journals in Spanish until July 2017 by handsearching...
2018: SAGE Open Medicine
MinKyoung Song, Christopher S Lee, Karen S Lyons, Sydnee Stoyles, Kerri M Winters-Stone
Objectives: Little is known about how children's health might be affected by parents' participation in commercial weight loss programs. Given that more than 3.2 million people subscribe to just one commercial weight loss program, Weight Watchers , any secondary effects on children's weight-related health behaviors (e.g. dietary behaviors, physical activity, and sedentary time) and body mass index from parent participation in commercial weight loss programs may have significant public health implications...
2018: SAGE Open Medicine
Despoina Tzira, Anargyroula Prezerakou, Ioannis Papadatos, Artemis Vintila, Anastasia Bartzeliotou, Filia Apostolakou, Ioannis Papassotiriou, Vassiliki Papaevangelou
Objective: Measurement of salivary biomarkers can provide important information regarding hypothalamic-pituitary-adrenal axis activity both under normal conditions as well as in response to psychological or physical stress. Our aim was to correlate salivary stress markers, such as cortisol, α-amylase and immunoglobulin A, with the Pediatric Risk Index Score of Mortality, underlying disease (pathologic, trauma and postoperative), need for mechanical ventilation/sedation and time lag between onset of illness and admission in children admitted in the pediatric intensive care unit...
2018: SAGE Open Medicine
Eivind Inderhaug, Carl-Henrik Schelp, Inge Glambek, Ivar S Kristiansen
Objective: The aim of this work was to estimate cost-effectiveness of five common procedures for varicose vein surgery ( high ligation and stripping, radiofrequency ablation, endovenous laser ablation, steam vein sclerosis and cyanoacrylate glue ) in a Norwegian setting from both a societal and a healthcare payer perspective. Design: Cost-effectiveness analysis using decision tree modelling. Methods: A structured literature search was conducted to estimate the clinical effectiveness and the rate of complications in the five methods...
2018: SAGE Open Medicine
Maria Cristina Queiroga
Objectives: Mastitis is responsible for a decrease in milk yield and quality. Disease control is vital for producers' profit and for consumer's welfare. This study aimed at investigating the immune response to Staphylococcus epidermidis intramammary infection. Methods: A total of 14 S. epidermidis isolates from milk collected from ewes with subclinical mastitis were used. Protein extracts were prepared and analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis...
2018: SAGE Open Medicine
Satoshi Kimura, Muhammad Shabsigh, Hiroshi Morimatsu
Purpose: The traditional approach and the Stewart approach have been developed for evaluating acid-base phenomena. While some experts have suggested that the two approaches are essentially identical, clinical researches have still been conducted on the superiority of one approach over the other one. In this review, we summarize the concepts of each approach and investigate the reasons of the discrepancy, based on current evidence from the literature search. Methods: In the literature search, we completed a database search and reviewed articles comparing the Stewart approach with the traditional, bicarbonate-centered approach to November 2016...
2018: SAGE Open Medicine
Christian Mackey, Melissa A Plegue, Marian Deames, Matthew Kittle, Kendrin R Sonneville, Tammy Chang
Background and objectives: Added sugar consumption is a major risk factor for negative health outcomes and family physicians play an important role in educating patients regarding nutrition behaviors, such as consumption of added dietary sugar. The aim of this study was to describe the knowledge, attitudes, and behaviors of family physicians regarding added dietary sugar. Methods: An online questionnaire was administered to family physician members of the Council of Academic Family Medicine organizations, which support teaching physicians that train family physicians throughout the United States...
2018: SAGE Open Medicine
Somasundram Pillay, Kaveer Ramchandre
Background: With the increased prevalence of HIV pandemic, more focus is placed on pathology involving the central nervous system secondary to HIV infection. Medical computerised tomography scans have become an integral investigation at a regional hospital level. Objective: To provide a description of central nervous system space occupying infective lesion found within this cohort of patients. Setting: Edendale Hospital, Pietermaritzburg, KwaZulu-Natal...
2018: SAGE Open Medicine
Frederick North, Sidna M Tulledge-Scheitel, John C Matulis, Jennifer L Pecina, Andrew M Franqueira, Sarah S Johnson, Rajeev Chaudhry
Background: There are numerous recommendations from expert sources that help guide primary care providers in cancer screening, infectious disease screening, metabolic screening, monitoring of drug levels, and chronic disease management. Little is known about the potential effort needed for a healthcare system to address these recommendations, or the patient effort needed to complete the recommendations. Methods: For 73 recommended population healthcare items, we examined each of 28,742 patients in a primary care internal medicine practice to determine whether they were up-to-date on recommended screening, immunizations, counseling, and chronic disease management goals...
2018: SAGE Open Medicine
Al-Ola Abdallah, Hannah Coleman, Mohamed Kamel, Rodney Davis, Teri Landrum, Horace Spencer, Sam Mackintosh, Fade A Mahmoud, Natasa Milojkovic, Chester Wicker, Konstantinos Arnaoutakis, Mayumi Nakagawa
Objectives: Our group developed the use of the Candida skin test reagent as an adjuvant of cell-mediated immunity in designing a human papillomavirus therapeutic vaccine. Here, this technology is being applied for designing a prostate cancer immunotherapy. Methods: Peptides based on the prostate-specific antigen amino acid sequences were selected, synthesized, and evaluated in terms of their (1) solubility, (2) maturation effects on Langerhans cells by fluorescence-activated cell sorter analysis, and (3) recognition by peripheral immune cells from prostate cancer patients using interferon-γ enzyme-linked immunospot assay...
2018: SAGE Open Medicine
Chaocong Liang, Aijing Luo, Zhuqing Zhong
Objective: The objective of this study was to analyze knowledge mapping and demonstrate the status quo, intellectual base, and hotspots in the field of medication literacy. Methods: Using the data from Web of Science Core database, we constructed a knowledge map to visualize medication literacy using CiteSpace, which revealed the power of the studies, core authors and journals, intellectual base, and hotspots in this field. Results: According to an analysis of 2025 literature reports, the stronger studies were mainly conducted at research institutions of higher education in the United States...
2018: SAGE Open Medicine
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