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SAGE Open Medicine

Charlotte Myhre Jensen, Soren Overgaard, Uffe Kock Wiil, Anthony C Smith, Jane Clemensen
Objectives: In future healthcare systems, individuals are expected to be more involved in managing their health and preventing illness. A previous study of patient empowerment on a hip fracture pathway uncovered a gap between what the healthcare system provided and patients' needs and wishes. The aim of this study was to investigate whether a user-driven approach and a participatory design could provide a solution that would bridge this gap. Methods: Four workshops and a laboratory test were conducted with healthcare professionals to co-create a final prototype...
2018: SAGE Open Medicine
Yuanmay Chang
Objective: Far infrared radiation has been widely used in a variety of healthcare institutions and clinical research. Previous studies have shown that far infrared radiation can promote blood circulation and enhance the functioning of the immune system. Many patients receiving peritoneal dialysis have been co-treated with far infrared radiation to reduce the occurrence of inflammation. This study seeks to evaluate the effects of far infrared radiation therapy on inflammation. Method: We used the lipopolysaccharide-induced peritonitis mouse model to study the effect of far infrared radiation treatment...
2018: SAGE Open Medicine
Ülkü Türk Börü, Ahmet Şükrü Kulualp, Ömer Faruk Tarhan, Cem Bölük, Arda Duman, Gökçe Zeytin Demiral, İlknur Güçlü Altun, Mustafa Taşdemir
Background: The population-based information on the prevalence of stroke from rural areas of Middle East countries including Turkey is unknown. Our aim is to evaluate the prevalence of stroke in those ⩾18 years in the Turkish population in a rural area of Istanbul. Methods: A cross-sectional door-to-door study was conducted in a rural area of Istanbul between 1 March and 30 March 2013. A research protocol recommended by World Health Organization for developing countries was used...
2018: SAGE Open Medicine
Andrea Duncan, Zinnia Batliwalla
Objectives: To understand the quality-of-life implications for post-polio syndrome survivors. Methods: For this qualitative study, a focus group methodology, with a case study design, was used. The data were analyzed for themes using a social ecological conceptual framework. Results: Three focus groups were conducted with a total of 24 participants (N = 24). Participants defined quality of life as being able to engage in meaningful activities of daily living...
2018: SAGE Open Medicine
Helen Razmjou, Tim Dwyer, Richard Holtby
Objectives: It is not clear if using patients with bilateral symptoms would impact the level of disability reported in orthopaedic research. The purposes of this study were to (1) examine the prevalence of bilateral shoulder symptoms (significant pain, stiffness or weakness affecting function) in patients with rotator cuff impingement syndrome, rotator cuff tear and osteoarthritis of the glenohumeral joint, (2) explore risk factors associated with bilateral shoulder symptoms, and (3) examine the impact of symptom bilaterality and hand dominance on pre- and post-operative patient-oriented disability outcomes...
2018: SAGE Open Medicine
Yosef Joseph Segman, Ella Sheiman
Objectives: This validation test was conducted in the Fujisan Blood Bank, Fortaleza, Brazil and evaluated the noninvasive TensorTip MTX (MTX, Cnoga Medical Ltd.) readings of hemoglobin, hematocrit, red blood cells, blood pressure, and heart rate compared to reference lab device readings. Generally, these parameters are measured from venous or capillary blood samples run on a laboratory analyzer or handheld invasive testing devices. Needle sticks are inconvenient to blood donors with relatively high exposure risks...
2018: SAGE Open Medicine
Sylvie Zongo, Mabel Carabali, Marie Munoz, Valéry Ridde
Objectives: Dengue fever remains unrecognized and under-reported in Africa due to several factors, including health professionals' lack of awareness, important prevalence of other febrile illnesses, most of which are treated presumptively as malaria, and the absence of surveillance systems. In Burkina Faso, health centers have no diagnostic tools to identify and manage dengue, which remains ignored, despite the evidence of seasonal outbreaks in recent years. A qualitative study was conducted to analyze the use of rapid diagnostic tests in six health and social promotion centers (i...
2018: SAGE Open Medicine
Jan Titulaer, Habibollah Arefian, Michael Hartmann, Mustafa Z Younis, Orlando Guntinas-Lichius
Allergic rhinitis is serious public health problems and one of the most common chronic diseases worldwide. We aimed to assess the cost-effectiveness of clinically relevant treatment options for allergic rhinitis using evidence-based literature. In addition, we aimed to develop recommendations for allergic rhinitis treatment based on health economic facts. We searched MEDLINE via PubMed from 2009 to 2014 to identify all therapeutic options described in the current literature and selected randomized controlled trials that used a symptom score, had at least one placebo control group and used adult patients...
2018: SAGE Open Medicine
Adeyi A Adoga, Daniel D Kokong, Nuhu D Ma'an, Joyce G Mugu, Chukwunonso J Mgbachi, Ayuba M Dauda
Background: Stage of head and neck cancers at presentation is a strong determinant of outcomes. Objective: To evaluate predictors of stage of head and neck cancers at presentation and survival in a Nigerian tertiary hospital. Patients and methods: Health records that met the inclusion criteria for head and neck cancers were retrieved using the International Classification of Diseases, 10th revision and analyzed with associations between variables modeled using logistic regression analysis...
2018: SAGE Open Medicine
Jeff Kirk Svane, Ingrid Egerod, Hanne Tønnesen
Objectives: Health promotion is on the global agenda. The risks targeted include smoking, hazardous alcohol consumption, nutrition and insufficient physical activity. Implementation of clinical health promotion, however, remains a major challenge. While several processes, models and frameworks for strategic implementation exist, very few have been tested in randomized designs. Testing a strategic implementation process for clinical health promotion was only recently attempted via a randomized clinical trial on the World Health Organization Health Promotion Hospitals Recognition Process...
2018: SAGE Open Medicine
Mindy E Flanagan, Laurie Plue, Kristine K Miller, Arlene A Schmid, Laura Myers, Glenn Graham, Edward J Miech, Linda S Williams, Teresa M Damush
Objectives: To compare activities and field descriptions of clinical champions across three levels of stroke centers. Methods: A cross-sectional qualitative study using quota sampling was conducted. The setting for this study was 38 acute stroke centers based in US Veterans Affairs Medical Centers with 8 designated as Primary, 24 as Limited Hours, and 6 as Stroke Support Centers. Key informants involved in stroke care were interviewed using a semi-structured approach...
2018: SAGE Open Medicine
Tracy Hellem, Hayden Ferguson
Background: OULA is a high-energy dance workout to top 40 hits that is inspired by yoga and non-impact aerobics. Created in Missoula, Montana, the program has been gaining national and international popularity. To understand the demographic composition, reasons for attending OULA, and experiences with depression/anxiety, we conducted an Internet-based survey. Methods: A pilot descriptive cross-sectional Internet-based survey was created in Qualtrics and distributed through social media and flyers...
2018: SAGE Open Medicine
Rebecca L Mullin, John F Golding, Rebecca Smith, Victoria Williams, Mary Thomas, Rosalie E Ferner
Objectives: To determine intra-rater and inter-rater reliability of functional outcome measures in adults with neurofibromatosis 1 and to ascertain how closely objective and subjective measures align. Methods: A total of 49 ambulant adults with neurofibromatosis 1 aged 16 years and over were included in this observational study: median age 31 years (range: 16-66 years), 29 females, 20 males. Participants were video-recorded or photographed performing four functional outcome measures...
2018: SAGE Open Medicine
Salman Alahmed, Irfan Anjum, Emad Masuadi
Objectives: Cultural beliefs often affect people's attitude toward mental illness and their help-seeking behavior. Belief in superstitious causes of mental illness can lead to seeking help from non-medical practitioners, which might hinder treatment. This study aimed to explore the perception of mental illness and help-seeking behavior among healthcare students. Methods: A cross-sectional study carried out on a sample of 400 randomly selected undergraduate health professional students in Riyadh...
2018: SAGE Open Medicine
Jemal Mohammed, Fitsum Weldegebreal, Zelalem Teklemariam, Habtamu Mitiku
Background: Schistosoma mansoni is a major public health problem. Different studies reported unidentified sites in Ethiopia with variable prevalence and intensity, but there is no report from this study area. Objective: To assess the clinico-epidemiology, malacology, risk factors, and community awareness of S. mansoni in Haradenaba and Dertoramis kebeles in the Bedeno district, eastern Ethiopia. Methods: A cross-sectional study was conducted among 1011 study participants in 413 systematically selected households from Haradenaba and Dertoramis kebeles from 30 June 2016 to 30 July 2017...
2018: SAGE Open Medicine
Shareni Jeyamogan, Naveed Ahmed Khan, Ayaz Anwar, Muhammad Raza Shah, Ruqaiyyah Siddiqui
Objectives: To synthesize novel compounds belonging to Benzodioxane, Naphthalene diimide, Aminophenol derivatives and Porphyrin classes and test their potential anticancer properties. Methods: Several compounds were synthesized and their molecular identity was confirmed using nuclear magnetic resonance. Potential anticancer properties were determined using cytopathogenicity assays and growth inhibition assays using cervical cancer cells (HeLa). Cells were incubated with different concentrations of compounds belonging to Benzodioxane, Naphthalene diimide, Aminophenol derivatives and Porphyrins and effects were determined...
2018: SAGE Open Medicine
Rosamund J Wilson, Beverly Jones, Claudio Marelli
Objectives: The recent availability of iron-based phosphate binders has raised some concerns about iron overload in patients with end-stage renal disease. This study evaluated iron parameters in patients with end-stage renal disease receiving lanthanum carbonate or other non-iron-based phosphate binders. Methods: This analysis used 2-year follow-up data from an open-label, multicentre, randomized, active-controlled, parallel-group, phase 3 trial of lanthanum carbonate (SPD405-307)...
2018: SAGE Open Medicine
Nazmus Saquib, Robert Brunner, Manisha Desai, Matthew Allison, Lorena Garcia, Marcia L Stefanick
Objectives: This study assessed whether the physical component summary score of the RAND-36 health-related quality-of-life survey was associated with incidence of coronary heart disease, stroke, congestive heart failure, angina, or peripheral arterial disease, and whether baseline chronic conditions modified these associations. Methods: Analysis was limited to 69,155 postmenopausal women (50-79 years) in the Women's Health Initiative Study who had complete data on the RAND-36, the outcomes, and covariates...
2018: SAGE Open Medicine
Fredrik Elg, Sharon Hunt
Objectives: Low tissue oxygenation is a predictor of healing outcomes in complex wounds. Adjunct hemoglobin to aid oxygen diffusion has been demonstrated to achieve superior healing outcomes; however, the relative healing benefit across different wound types and evaluations has not yet been estimated. This article does this for the first time. Methods: Data were pooled from previously published real world controlled evaluations, three retrospective cohort controlled studies of a variety of wounds within standard care across hospital and primary care in the North of England in patients with diabetic foot ulcers (n = 40), chronic wounds (n = 100), and sloughy wounds (n = 200)...
2018: SAGE Open Medicine
Olubunmi O Olubamwo, Ifeoma N Onyeka, Alex Aregbesola, Kimmo Ronkainen, Jari Tiihonen, Jaana Föhr, Jussi Kauhanen
Objective: The study examined the determinants of being hospitalized for pneumonia in a large cohort of drug users. Methods: Information of 4817 clients seeking treatment for illicit drug use was linked with the Finnish hospital discharge register to identify those who were hospitalized with main/primary diagnoses of pneumonia during 1997-2013. Cox regression models were used to examine the association between age, gender, homelessness, and route of drug administration of the primary drug at initial clinical consultation and pneumonia hospitalization...
2018: SAGE Open Medicine
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