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IEEE Journal of Translational Engineering in Health and Medicine

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https://www.readbyqxmd.com/read/28512610/melanoma-is-skin-deep-a-3d-reconstruction-technique-for-computerized-dermoscopic-skin-lesion-classification
#1
T Y Satheesha, D Satyanarayana, M N Giri Prasad, Kashyap D Dhruve
Melanoma mortality rates are the highest amongst skin cancer patients. Melanoma is life threating when it grows beyond the dermis of the skin. Hence, depth is an important factor to diagnose melanoma. This paper introduces a non-invasive computerized dermoscopy system that considers the estimated depth of skin lesions for diagnosis. A 3-D skin lesion reconstruction technique using the estimated depth obtained from regular dermoscopic images is presented. On basis of the 3-D reconstruction, depth and 3-D shape features are extracted...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28507827/wearable-improved-vision-system-for-color-vision-deficiency-correction
#2
Paolo Melillo, Daniel Riccio, Luigi Di Perna, Gabriella Sanniti Di Baja, Maurizio De Nino, Settimio Rossi, Francesco Testa, Francesca Simonelli, Maria Frucci
Color vision deficiency (CVD) is an extremely frequent vision impairment that compromises the ability to recognize colors. In order to improve color vision in a subject with CVD, we designed and developed a wearable improved vision system based on an augmented reality device. The system was validated in a clinical pilot study on 24 subjects with CVD (18 males and 6 females, aged 37.4 ± 14.2 years). The primary outcome was the improvement in the Ishihara Vision Test score with the correction proposed by our system...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28507826/near-infrared-imaging-for-detecting-caries-and-structural-deformities-in-teeth
#3
Keith Angelino, David A Edlund, Pratik Shah
2-D radiographs, while commonly used for evaluating sub-surface hard structures of teeth, have low sensitivity for early caries lesions, particularly those on tooth occlusal surfaces. Radiographs are also frequently refused by patients over safety concerns. Translucency of teeth in the near-infrared (NIR) range offers a non-ionizing and safe approach to detect dental caries. We report the construction of an NIR (850 nm) LED imaging system, comprised of an NIR source and an intraoral camera for rapid dental evaluations...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28507825/spatiotemporal-strategies-for-joint-segmentation-and-motion-tracking-from-cardiac-image-sequences
#4
Huafeng Liu, Ting Wang, Lei Xu, Pengcheng Shi
Although accurate and robust estimations of the deforming cardiac geometry and kinematics from cine tomographic medical image sequences remain a technical challenge, they have significant clinical value. Traditionally, boundary or volumetric segmentation and motion estimation problems are considered as two sequential steps, even though the order of these processes can be different. In this paper, we present an integrated, spatiotemporal strategy for the simultaneous joint recovery of these two ill-posed problems...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28507824/non-invasive-radiofrequency-field-treatment-to-produce-hepatic-hyperthermia-efficacy-and-safety-in-swine
#5
Jason C Ho, Lam Nguyen, Justin J Law, Matthew J Ware, V Keshishian, N C Lara, Trac Nguyen, Steven A Curley, Stuart J Corr
The Kanzius non-invasive radio-frequency hyperthermia system (KNiRFH) has been investigated as a treatment option for hepatic hyperthermia cancer therapy. The treatment involves exposing the patient to an external high-power RF (13.56 MHz) electric field, whereby the propagating waves penetrate deep into the tumor causing targeted heating based on differential tissue dielectric properties. However, a comprehensive examination of the Kanzius system alongside any associated toxicities and its ability to induce hepatic hyperthermia in larger animal models, such as swine, are the subjects of the work herein...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28439481/sit-to-stand-transition-reveals-acute-fall-risk-in-activities-of-daily-living
#6
Tomislav Pozaic, Ulrich Lindemann, Anna-Karina Grebe, Wilhelm Stork
The focus of this paper was on finding wrist sensor-derived features for detecting highly acute fall risk from the sit-to-stand transitions performed in a non-ambulatory environment. Furthermore, the influence of the dominant and non-dominant hand on these features was investigated. A cohort of 174 older subjects was monitored for seven consecutive days in their home setting by using inertial sensors attached at the wrist. Based on the reported falls during a one-month follow-up phase, two groups were defined...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28424753/image-guided-high-intensity-focused-ultrasound-system-for-large-animal-nerve-ablation-studies
#7
Arthur Worthington, Philip Peng, Kevin Rod, Vera Bril, Jahan Tavakkoli
High intensity focused ultrasound (HIFU) is a form of thermal ablation technique, which can treat a variety of medical afflictions. One promising therapeutic use is the permanent destruction of nerves non-invasively in patients with severe spasticity or certain types of pain (e.g., phantom limb pain). To this end, HIFU requires ultrasound guidance, which allows the non-invasive, target-specific deposition of thermal energy to the targeted nerve, thereby blocking axonal conduction. In this paper, a composite system comprising both ultrasound-imaging and HIFU therapy was developed and used to induce localized non-invasive nerve blockage in an in vivo large animal study...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27957405/smart-helmet-wearable-multichannel-ecg-and-eeg
#8
Wilhelm Von Rosenberg, Theerasak Chanwimalueang, Valentin Goverdovsky, David Looney, David Sharp, Danilo P Mandic
Modern wearable technologies have enabled continuous recording of vital signs, however, for activities such as cycling, motor-racing, or military engagement, a helmet with embedded sensors would provide maximum convenience and the opportunity to monitor simultaneously both the vital signs and the electroencephalogram (EEG). To this end, we investigate the feasibility of recording the electrocardiogram (ECG), respiration, and EEG from face-lead locations, by embedding multiple electrodes within a standard helmet...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27957404/effects-of-real-world-versus-virtual-environments-on-joint-excursions-in-full-body-reaching-tasks
#9
James S Thomas, Christopher R France, Samuel T Leitkam, Megan E Applegate, Peter E Pidcoe, Stevan Walkowski
Starting from an upright standing posture and reaching for a target that requires some forward bending of the trunk can involve many different configurations of the trunk and limb segments. We sought to determine if configurations of the limb and trunk segments during our standardized full-body reaching tasks were influenced by the visual environment. This paper examined movement patterns of healthy participants ([Formula: see text], eight female and nine male) performing full body reaching tasks to: 1) real-world targets; 2) virtual targets presented on a 3-D television; and 3) virtual targets presented using a head-mounted display...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27777829/non-invasive-neuromodulation-using-time-varying-caloric-vestibular-stimulation
#10
Robert D Black, Lesco L Rogers, Kristen K Ade, Heather A Nicoletto, Heather D Adkins, Daniel T Laskowitz
Caloric vestibular stimulation (CVS) to elicit the vestibulo-ocular reflex has long been used in clinical settings to aid in the diagnosis of balance disorders and to confirm the absence of brainstem function. While a number of studies have hinted at the potential therapeutic applications of CVS, the limitations of existing devices have frustrated that potential. Current CVS irrigators use water or air during short-duration applications; however, this approach is not tenable for longer duration therapeutic protocols or home use...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27766188/healthcare-commercialization-programs-improving-the-efficiency-of-translating-healthcare-innovations-from-academia-into-practice
#11
John M Collins, Ofer Reizes, Michael K Dempsey
Academic investigators are generating a plethora of insights and technologies that have the potential to significantly improve patient care. However, to address the imperative to improve the quality, cost and access to care with ever more constrained funding, the efficiency and the consistency with which they are translated into cost effective products and/or services need to improve. Healthcare commercialization programs (HCPs) are described and proposed as an option that institutions can add to their portfolio to improve translational research...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27766187/summary-of-human-ankle-mechanical-impedance-during-walking
#12
Hyunglae Lee, Elliott J Rouse, Hermano Igo Krebs
The human ankle joint plays a critical role during walking and understanding the biomechanical factors that govern ankle behavior and provides fundamental insight into normal and pathologically altered gait. Previous researchers have comprehensively studied ankle joint kinetics and kinematics during many biomechanical tasks, including locomotion; however, only recently have researchers been able to quantify how the mechanical impedance of the ankle varies during walking. The mechanical impedance describes the dynamic relationship between the joint position and the joint torque during perturbation, and is often represented in terms of stiffness, damping, and inertia...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27730016/a-system-for-simple-real-time-anastomotic-failure-detection-and-wireless-blood-flow-monitoring-in-the-lower-limbs
#13
Michael A Rothfuss, Nicholas G Franconi, Jignesh V Unadkat, Michael L Gimbel, Alexander Star, Marlin H Mickle, Ervin Sejdic
Current totally implantable wireless blood flow monitors are large and cannot operate alongside nearby monitors. To alleviate the problems with the current monitors, we developed a system to monitor blood flow wirelessly, with a simple and easily interpretable real-time output. To the best of our knowledge, the implanted electronics are the smallest in reported literature, which reduces bio-burden. Calibration was performed across realistic physiological flow ranges using a syringe pump. The device's sensors connected directly to the bilateral femoral veins of swine...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27730015/the-national-institutes-of-health-affordable-cancer-technologies-program-improving-access-to-resource-appropriate-technologies-for-cancer-detection-diagnosis-monitoring-and-treatment-in-low-and-middle-income-countries
#14
Paul C Pearlman, Rao Divi, Michael Gwede, Pushpa Tandon, Brian S Sorg, Miguel R Ossandon, Lokesh Agrawal, Vinay Pai, Houston Baker, Tiffani Bailey Lash
Point-of-care (POC) technologies have proved valuable in cancer detection, diagnosis, monitoring, and treatment in the developed world, and have shown promise in low-and-middle-income countries (LMIC) as well. Despite this promise, the unique design constraints presented in low-resource settings, coupled with the variety of country-specific regulatory and institutional dynamics, have made it difficult for investigators to translate successful POC cancer interventions to the LMIC markets. In response to this need, the National Cancer Institute has partnered with the National Institute of Biomedical Imaging and Bioengineering to create the National Institutes of Health Affordable Cancer Technologies (ACTs) program...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27730014/national-institute-of-biomedical-imaging-and-bioengineering-point-of-care-technology-research-network-advancing-precision-medicine
#15
Penny Ford Carleton, Steven Schachter, John A Parrish, John M Collins, J Benjamin Crocker, Ronald F Dixon, Susan Edgman-Levitan, Kent B Lewandrowski, James E Stahl, Catherine Klapperich, Mario Cabodi, Charlotte A Gaydos, Anne M Rompalo, Yukari Manabe, Tza-Huei Wang, Richard Rothman, Chris D Geddes, Lea Widdice, Joany Jackman, Rishi A Mathura, Tiffani Bailey Lash
To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and close facilitation to move technologies from an early stage of development into clinical testing and patient use. This paper describes the POCTRN and the three currently funded Centers as examples of academic-based organizations that support collaborations across disciplines, institutions, and geographic regions to successfully drive innovative solutions from concept to patient care...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27730013/the-importance-of-state-and-context-in-safe-interoperable-medical-systems
#16
Sandy Weininger, Michael B Jaffe, Michael Robkin, Tracy Rausch, David Arney, Julian M Goldman
This paper describes why "device state" and "patient context" information are necessary components of device models for safe interoperability. This paper includes a discussion of the importance of describing the roles of devices with respect to interactions (including human user workflows involving devices, and device to device communication) within a system, particularly those intended for use at the point-of-care, and how this role information is communicated. In addition, it describes the importance of clinical scenarios in creating device models for interoperable devices...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27730012/analysis-of-difference-in-center-of-pressure-positions-between-experts-and-novices-during-asymmetric-lifting
#17
Hieyong Jeong, Kenji Yamada, Michiko Kido, Shima Okada, Taishin Nomura, Yuko Ohno
Although numerous studies have analyzed the relationship between manual material handling (MMH) and the forces acting on the lumbar spine, the difference in the MMH between experts and novices through the analysis of measured data has not been well studied. The purpose of this paper was to analyze the difference in the MMH positions between ten skilled experts working at a freight transport company (Group 1) and five unskilled novices without any experience (Group 2) during asymmetric lifting. All the human subjects performed asymmetric lifting experiments with closed eyes; the experiments involved moving loads (6 and 18 kg) to the left side...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27620621/elucidating-the-hemodynamic-origin-of-ballistocardiographic-forces-toward-improved-monitoring-of-cardiovascular-health-at-home
#18
Abdul Qadir Javaid, Hazar Ashouri, Srini Tridandapani, Omer T Inan
The ballistocardiogram (BCG), a signal describing the reaction forces of the body to cardiac ejection of blood, has recently gained interest in the research community as a potential tool for monitoring the mechanical aspects of cardiovascular health for patients at home and during normal activities of daily living. An important limitation in the field of BCG research is that while the BCG signal measures the forces of the body, the information desired (and understood) by clinicians and caregivers, regarding mechanical health of the cardiovascular system, is typically expressed as blood pressure or flow...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27602308/point-of-care-technologies-for-the-advancement-of-precision-medicine-in-heart-lung-blood-and-sleep-disorders
#19
Mary Emma Gorham Bigelow, Brian G Jamieson, Chi On Chui, Yufei Mao, Kyeong-Sik Shin, Tony Jun Huang, Po-Hsun Huang, Liqiang Ren, Bishow Adhikari, Jue Chen, Erin Iturriaga
The commercialization of new point of care technologies holds great potential in facilitating and advancing precision medicine in heart, lung, blood, and sleep (HLBS) disorders. The delivery of individually tailored health care to a patient depends on how well that patient's health condition can be interrogated and monitored. Point of care technologies may enable access to rapid and cost-effective interrogation of a patient's health condition in near real time. Currently, physiological data are largely limited to single-time-point collection at the hospital or clinic, whereas critical information on some conditions must be collected in the home, when symptoms occur, or at regular intervals over time...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27602307/guiding-empiric-treatment-for-serious-bacterial-infections-via-point-of-care-formula-see-text-lactamase-characterization
#20
Akilan Palanisami, Shazia Khan, Sultan Sibel Erdem, Tayyaba Hasan
Fever is one of the most common symptoms of illness in infants and represents a clinical challenge due to the potential for serious bacterial infection. As delayed treatment for these infections has been correlated with increased morbidity and mortality, broad-spectrum [Formula: see text]-lactam antibiotics are often prescribed while waiting for microbiological lab results (1-3 days). However, the spread of antibiotic resistance via the [Formula: see text]-lactamase enzyme, which can destroy [Formula: see text]-lactam antibiotics, has confounded this paradigm; empiric antibiotic regimens are increasingly unable to cover all potential bacterial pathogens, leaving some infants effectively untreated until the pathogen is characterized...
2016: IEEE Journal of Translational Engineering in Health and Medicine
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