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International Journal of Bipolar Disorders

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https://www.readbyqxmd.com/read/30415424/detecting-significant-genotype-phenotype-association-rules-in-bipolar-disorder-market-research-meets-complex-genetics
#1
René Breuer, Manuel Mattheisen, Josef Frank, Bertram Krumm, Jens Treutlein, Layla Kassem, Jana Strohmaier, Stefan Herms, Thomas W Mühleisen, Franziska Degenhardt, Sven Cichon, Markus M Nöthen, George Karypis, John Kelsoe, Tiffany Greenwood, Caroline Nievergelt, Paul Shilling, Tatyana Shekhtman, Howard Edenberg, David Craig, Szabolcs Szelinger, John Nurnberger, Elliot Gershon, Ney Alliey-Rodriguez, Peter Zandi, Fernando Goes, Nicholas Schork, Erin Smith, Daniel Koller, Peng Zhang, Judith Badner, Wade Berrettini, Cinnamon Bloss, William Byerley, William Coryell, Tatiana Foroud, Yirin Guo, Maria Hipolito, Brendan Keating, William Lawson, Chunyu Liu, Pamela Mahon, Melvin McInnis, Sarah Murray, Evaristus Nwulia, James Potash, John Rice, William Scheftner, Sebastian Zöllner, Francis J McMahon, Marcella Rietschel, Thomas G Schulze
BACKGROUND: Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other complex disorders, major breakthroughs in explaining the high heritability of BD through GWAS have remained elusive. To overcome this dilemma, genetic research into BD, has embraced a variety of strategies such as the formation of large consortia to increase sample size and sequencing approaches...
November 11, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/30397833/the-challenges-of-living-with-bipolar-disorder-a-qualitative-study-of-the-implications-for-health-care-and-research
#2
Eva F Maassen, Barbara J Regeer, Eline J Regeer, Joske F G Bunders, Ralph W Kupka
BACKGROUND: In mental health care, clinical practice is often based on the best available research evidence. However, research findings are difficult to apply to clinical practice, resulting in an implementation gap. To bridge the gap between research and clinical practice, patients' perspectives should be used in health care and research. This study aimed to understand the challenges people with bipolar disorder (BD) experience and examine what these challenges imply for health care and research needs...
November 6, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/30341458/a-nationwide-study-on-concordance-with-multimodal-treatment-guidelines-in-bipolar-disorder
#3
Joannes W Renes, Eline J Regeer, Adriaan W Hoogendoorn, Willem A Nolen, Ralph W Kupka
BACKGROUND: Most previous studies on concordance with treatment guidelines for bipolar disorder focused on pharmacotherapy. Few studies have included other treatment modalities. AIMS: To study concordance with the Dutch guideline of various treatment modalities in outpatient treatment settings for patients with bipolar disorder and to identity factors associated with concordance. METHODS: A nationwide non-interventional study using psychiatrists' and patients' surveys...
October 20, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/30284089/shared-decision-making-in-pharmacotherapy-decisions-perceived-by-patients-with-bipolar-disorder
#4
Doris Verwijmeren, Koen P Grootens
BACKGROUND: Shared decision making has been promoted as standard care, but there has been debate on the possible types. On the one hand, there is a more 'instrumental'/objective approach focused on the exchange of information, but an 'interpersonal'/subjective patient involvement has been suggested as well. In this study we aim to investigate this further by assessing both actual and perceived patient involvement in medical decisions. METHODS: Eighty-one consultations between patients with bipolar disorder and their clinicians were observed and scored using the OPTION scale...
October 4, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/30198055/clinical-characteristics-of-patients-with-bipolar-disorder-and-premorbid-traumatic-brain-injury-a-cross-sectional-study
#5
Ole Kristian Drange, Arne Einar Vaaler, Gunnar Morken, Ole Andreas Andreassen, Ulrik Fredrik Malt, Per Ivar Finseth
BACKGROUND: About one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical condition (BD due to TBI). We investigated whether these patients have similar clinical characteristics as previously described in BD due to TBI (i.e. more aggression and irritability and an increased hypomania/mania:depression ratio) and other distinct clinical characteristics...
September 10, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/30178112/internet-use-by-older-adults-with-bipolar-disorder-international-survey-results
#6
Rita Bauer, Tasha Glenn, Sergio Strejilevich, Jörn Conell, Martin Alda, Raffaella Ardau, Bernhard T Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Angela M Paredes Castro, Eric Y W Cheung, Caterina Chillotti, Sabine Choppin, Alessandro Cuomo, Maria Del Zompo, Rodrigo Dias, Seetal Dodd, Anne Duffy, Bruno Etain, Andrea Fagiolini, Miryam Fernández Hernandez, Julie Garnham, John Geddes, Jonas Gildebro, Michael J Gitlin, Ana Gonzalez-Pinto, Guy M Goodwin, Paul Grof, Hirohiko Harima, Stefanie Hassel, Chantal Henry, Diego Hidalgo-Mazzei, Anne Hvenegaard Lund, Vaisnvy Kapur, Girish Kunigiri, Beny Lafer, Erik R Larsen, Ute Lewitzka, Rasmus W Licht, Blazej Misiak, Patryk Piotrowski, Ângela Miranda-Scippa, Scott Monteith, Rodrigo Munoz, Takako Nakanotani, René E Nielsen, Claire O'Donovan, Yasushi Okamura, Yamima Osher, Andreas Reif, Philipp Ritter, Janusz K Rybakowski, Kemal Sagduyu, Brett Sawchuk, Elon Schwartz, Claire Slaney, Ahmad H Sulaiman, Kirsi Suominen, Aleksandra Suwalska, Peter Tam, Yoshitaka Tatebayashi, Leonardo Tondo, Julia Veeh, Eduard Vieta, Maj Vinberg, Biju Viswanath, Mark Zetin, Peter C Whybrow, Michael Bauer
BACKGROUND: The world population is aging and the number of older adults with bipolar disorder is increasing. Digital technologies are viewed as a framework to improve care of older adults with bipolar disorder. This analysis quantifies Internet use by older adults with bipolar disorder as part of a larger survey project about information seeking. METHODS: A paper-based survey about information seeking by patients with bipolar disorder was developed and translated into 12 languages...
September 4, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/30097737/aggression-among-216-patients-with-a-first-psychotic-episode-of-bipolar-i-disorder
#7
Hari-Mandir K Khalsa, Ross J Baldessarini, Mauricio Tohen, Paola Salvatore
BACKGROUND: Aggression by patients with bipolar I disorder (BD-I) is not uncommon. Identifying potential risk factors early in the illness-course should inform clinical management and reduce risk. METHODS: In a study sample of 216 initially hospitalized, first-psychotic episode subjects diagnosed with DSM-IV-TR BD-I, we identified recent (within 1 month before hospitalization) aggression by ratings on the Brief Psychiatric Rating Scale-Expanded and review of detailed clinical research records...
August 11, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/30079440/thyroid-and-renal-tumors-in-patients-treated-with-long-term-lithium-case-series-from-a-lithium-clinic-review-of-the-literature-and-international-pharmacovigilance-reports
#8
REVIEW
Luca Ambrosiani, Claudia Pisanu, Arianna Deidda, Caterina Chillotti, Maria Erminia Stochino, Alberto Bocchetta
BACKGROUND: Cancer had never been considered as a relevant problem in patients treated with lithium until 2015, when a document published by the European Medicine Agency concluded that long-term use of lithium might induce renal tumors. A few months later, we observed the case of a woman treated with lithium for 18 years who was diagnosed with both thyroid and renal tumors. METHODS: This study aimed to investigate the correlation between lithium treatment and thyroid or renal tumors...
August 6, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29992455/regional-cortical-thinning-in-young-adults-with-schizophrenia-but-not-psychotic-or-non-psychotic-bipolar-i-disorder
#9
Douglass Godwin, Kathryn I Alpert, Lei Wang, Daniel Mamah
BACKGROUND: Schizophrenia shares some genetic risk and clinical symptoms with bipolar disorder. Clinical heterogeneity across subjects is thought to contribute to variable structural imaging findings across studies. The current study investigates cortical thickness in young adults diagnosed with schizophrenia or bipolar I disorder with a history of hyperthymic mania. We hypothesize that cortical thickness will be most similar between SCZ and the psychotic bipolar 1 disorder subtype. METHODS: Patients with schizophrenia (n = 52), psychotic bipolar I disorder (PBD; n = 49) and non-psychotic bipolar I disorder (NPBD; n = 24) and healthy controls (n = 40) were scanned in a 3T Trio MRI...
July 11, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29968068/lack-of-emotional-gaze-preferences-using-eye-tracking-in-remitted-bipolar-i-disorder
#10
John R Purcell, Monika Lohani, Christie Musket, Aleena C Hay, Derek M Isaacowitz, June Gruber
BACKGROUND: Bipolar disorder is associated with heightened and persistent positive emotion (Gruber in Curr Dir Psychol Sci 20:217-221, 2011; Johnson in Clin Psychol Rev 25:241-262, 2005). Yet little is known about information processing biases that may influence these patterns of emotion responding. METHODS: The current study adopted eye-tracking methodology as a continuous measure of sustained overt attention to monitor gaze preferences during passive viewing of positive, negative, and neutral standardized photo stimuli among remitted bipolar adults and healthy controls...
July 3, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29886522/aripiprazole-once-monthly-as-maintenance-treatment-for-bipolar-i-disorder-a-52-week-multicenter-open-label-study
#11
Joseph R Calabrese, Na Jin, Brian Johnson, Pedro Such, Ross A Baker, Jessica Madera, Peter Hertel, Jocelyn Ottinger, Joan Amatniek, Hiroaki Kawasaki
BACKGROUND: The long-acting injectable antipsychotic aripiprazole once-monthly 400 mg (AOM 400) was recently approved for maintenance treatment of bipolar I disorder (BP-I). The purpose of this study was to evaluate the safety, tolerability, and efficacy of AOM 400 as long-term maintenance treatment for BP-I. METHODS: This open-label multicenter study evaluated the effectiveness of AOM 400 as maintenance treatment for BP-I by assessing safety and tolerability (primary objective) and efficacy (secondary objective)...
June 10, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29858927/the-perspectives-of-patients-with-lithium-induced-end-stage-renal-disease
#12
Angèle P M Kerckhoffs, Erwin G T M Hartong, Koen P Grootens
BACKGROUND: Lithium is the treatment of choice for patients suffering from bipolar disorder (BD) but prolonged use induces renal dysfunction in at least 20% of patient. Intensive monitoring of kidney functioning helps to reveal early decline in renal failure. This study investigates the views and experiences of BD patients who have developed end-stage renal disease and were receiving renal replacement therapy. RESULTS: The patients overall reported not to have been offered alternative treatment options at the start of lithium therapy or when renal functions deteriorated...
June 2, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29730832/behavioural-biomarkers-and-mobile-mental-health-a-new-paradigm
#13
LETTER
Diego Hidalgo-Mazzei, Allan H Young, Eduard Vieta, Francesc Colom
Over recent decades, the field of psychiatry has allocated a vast amount of resources and efforts to make available more accurate and objective methods to diagnose, assess and monitor treatment outcomes in psychiatric disorders. Despite the optimism and some significant progress in biological markers, it has become increasingly evident that they are failing to meet initial expectations due to their lack of specificity, inconsistent reliability and limited availability. On the other hand, there is an increasingly emerging evidence of mobile technologies' feasibility to measure mental illness activity...
May 6, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29713845/regularity-of-self-reported-daily-dosage-of-mood-stabilizers-and-antipsychotics-in-patients-with-bipolar-disorder
#14
Maximilian Pilhatsch, Tasha Glenn, Natalie Rasgon, Martin Alda, Kemal Sagduyu, Paul Grof, Rodrigo Munoz, Wendy Marsh, Scott Monteith, Emanuel Severus, Rita Bauer, Philipp Ritter, Peter C Whybrow, Michael Bauer
BACKGROUND: Polypharmacy is often prescribed for bipolar disorder, yet medication non-adherence remains a serious problem. This study investigated the regularity in the daily dosage taken of mood stabilizers and second generation antipsychotics. METHODS: Daily self-reported data on medications taken and mood were available from 241 patients with a diagnosis of bipolar disorder who received treatment as usual. Patients who took the same mood stabilizer or second generation antipsychotic for ≥ 100 days were included...
May 1, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29654479/monitoring-of-patients-treated-with-lithium-for-bipolar-disorder-an-international-survey
#15
M Nederlof, E R Heerdink, A C G Egberts, I Wilting, L J Stoker, R Hoekstra, R W Kupka
BACKGROUND: Adequate monitoring of patients using lithium is needed for optimal dosing and for early identification of patients with (potential) ADEs. The objective was to internationally assess how health care professionals monitor patients treated with lithium for bipolar disorder. METHODS: Using networks of various professional organizations, an anonymous online survey was conducted among health care professionals prescribing lithium. Target lithium serum levels and frequency of monitoring was assessed together with monitoring of physical and laboratory parameters...
April 14, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29619634/add-on-treatment-with-n-acetylcysteine-for-bipolar-depression-a-24-week-randomized-double-blind-parallel-group-placebo-controlled-multicentre-trial-nacos-study-protocol
#16
Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Henrik Enghusen Poulsen, René Ernst Nielsen, Michael Berk, Olivia May Dean, Mohammadreza Mohebbi, Connie Thuroee Nielsen
BACKGROUND: Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depressive episodes, especially compared with the efficacy of treatment for acute mania. N-Acetylcysteine (NAC) has been explored for psychiatric disorders for some time given its antioxidant and anti-inflammatory properties. The current trial aims at testing the clinical effects of adjunctive NAC treatment (compared to placebo) for bipolar depression...
April 5, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29616434/control-charts-for-monitoring-mood-stability-as-a-predictor-of-severe-episodes-in-patients-with-bipolar-disorder
#17
Maria D L A Vazquez-Montes, Richard Stevens, Rafael Perera, Kate Saunders, John R Geddes
BACKGROUND: Recurrent mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder. Early identification of mood episodes enabling timely mood stabilization is an important clinical goal. This study investigates the ability of control chart methodology to predict manic and/or depressive episodes by applying Shewhart's control rules to weekly self-reported scores from mania and depression questionnaires. METHODS: Shewhart's control rules were applied to weekly self-reported scores from the Altman Self-Rating Mania Scale (ASRM) and the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS) collected from 2001 to 2012 as part of the OXTEXT programme...
April 4, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29511876/actigraphy-as-an-objective-intra-individual-marker-of-activity-patterns-in-acute-phase-bipolar-disorder-a-case-series
#18
Karoline Krane-Gartiser, Andreas Asheim, Ole Bernt Fasmer, Gunnar Morken, Arne E Vaaler, Jan Scott
BACKGROUND: Actigraphy could be an objective alternative to clinical ratings of motor activity in bipolar disorder (BD), which is of importance now that increased activity and energy are added as cardinal symptoms of (hypo)mania in the DSM-5 and commonly used rating scales give inadequate information about motor symptoms. To date, most actigraphy studies have been conducted in groups and/or used mean activity levels as the variable of interest. The novelty of this case series is therefore to indicate the potential of actigraphy and non-parametric analysis as an objective and personalized marker of intra-individual activity patterns in different phases of BD...
March 7, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29492700/circulating-antithyroid-antibodies-contribute-to-the-decrease-of-glomerular-filtration-rate-in-lithium-treated-patients-a-longitudinal-study
#19
Alberto Bocchetta, Luca Ambrosiani, Gioia Baggiani, Claudia Pisanu, Caterina Chillotti, Raffaella Ardau, Fernanda Velluzzi, Doloretta Piras, Andrea Loviselli, Antonello Pani
BACKGROUND: Concerns about the adverse effects of long-term treatment with lithium include reduced renal function. In the present study, we examined comorbidities which may be associated with chronic kidney disease in a cohort of patients treated with lithium for up to 41 years. METHODS: We studied 394 patients who were treated with lithium for ≥ 5 years. The potential role of comorbidities (diabetes, concurrent antihypertensive medication, treatment with L-thyroxine, and presence of antithyroid peroxidase/microsomes, anti-thyroglobulin, and/or anti-thyrotropin-receptor antibodies) was analysed...
March 1, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29457195/the-association-between-mood-state-and-chronobiological-characteristics-in-bipolar-i-disorder-a-naturalistic-variable-cluster-analysis-based-study
#20
Robert Gonzalez, Trisha Suppes, Jamie Zeitzer, Colleen McClung, Carol Tamminga, Mauricio Tohen, Angelica Forero, Alok Dwivedi, Andres Alvarado
BACKGROUND: Multiple types of chronobiological disturbances have been reported in bipolar disorder, including characteristics associated with general activity levels, sleep, and rhythmicity. Previous studies have focused on examining the individual relationships between affective state and chronobiological characteristics. The aim of this study was to conduct a variable cluster analysis in order to ascertain how mood states are associated with chronobiological traits in bipolar I disorder (BDI)...
February 19, 2018: International Journal of Bipolar Disorders
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