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International Journal of Bipolar Disorders

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https://www.readbyqxmd.com/read/28188565/poor-quality-of-life-and-functioning-in-bipolar-disorder
#1
Louisa G Sylvia, Rebecca E Montana, Thilo Deckersbach, Michael E Thase, Maurcio Tohen, Noreen Reilly-Harrington, Melvin G McInnis, James H Kocsis, Charles Bowden, Joseph Calabrese, Keming Gao, Terence Ketter, Richard C Shelton, Susan L McElroy, Edward S Friedman, Dustin J Rabideau, Andrew A Nierenberg
BACKGROUND: This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder. METHODS: Adult participants (N = 482) with bipolar I or II disorder were enrolled in a comparative effectiveness study across eleven study sites and completed baseline measures of medical and psychiatric history, current mood, quality of life, and functioning. Participants with at least mildly depressive or manic/hypomanic symptomatic severity were randomized to receive lithium or quetiapine in addition to adjunctive personalized treatment for 6 months...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28168632/long-term-use-of-lurasidone-in-patients-with-bipolar-disorder-safety-and-effectiveness-over-2%C3%A2-years-of-treatment
#2
Andrei Pikalov, Joyce Tsai, Yongcai Mao, Robert Silva, Josephine Cucchiaro, Antony Loebel
BACKGROUND: Bipolar disorder is a chronic illness with a 2-year recurrence rate of approximately 50% among individuals receiving treatment in the community. The aim of this 18-month, open-label, continuation study was to evaluate the long-term safety and effectiveness of lurasidone in patients who initially presented with a major depressive episode associated with bipolar disorder, and who had completed at least 6 months of initial treatment with lurasidone. METHODS: Patients with bipolar I depression were enrolled in one of three 6-week, double-blind, placebo-controlled trials (monotherapy with lurasidone, 1 study; adjunctive therapy with lurasidone; and lithium or valproate, 2 studies)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28168631/cognitive-remediation-for-bipolar-patients-with-objective-cognitive-impairment-a-naturalistic-study
#3
J Veeh, J Kopf, S Kittel-Schneider, J Deckert, A Reif
BACKGROUND: Many bipolar patients (BP) are affected by cognitive impairments and reduced psychosocial function even after complete remission. In the present naturalistic study, we developed a tailored cognitive remediation program (CR) to evaluate the effect on objective and subjective neuropsychological performance, psychosocial functioning and quality of life. METHODS: The CR program used a cognitive training software combined with group sessions to educate cognitive skills...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28155207/prodrome-or-risk-syndrome-what-s-in-a-name
#4
Pierre Alexis Geoffroy, Jan Scott
BACKGROUND: In the last decade, an increasing number of publications have examined the precursors of bipolar disorders (BD) and attempted to clarify the early origins and illness trajectory. This is a complex task as the evolution of BD often shows greater heterogeneity than psychosis, and the first onset episode of BD may be dominated by depressive or manic features or both. To date, most of the published reviews have not clarified whether they are focused on prodromes, risk syndromes or addressing both phenomena...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28155206/ethical-perspectives-on-recommending-digital-technology-for-patients-with-mental-illness
#5
REVIEW
Michael Bauer, Tasha Glenn, Scott Monteith, Rita Bauer, Peter C Whybrow, John Geddes
The digital revolution in medicine not only offers exciting new directions for the treatment of mental illness, but also presents challenges to patient privacy and security. Changes in medicine are part of the complex digital economy based on creating value from analysis of behavioral data acquired by the tracking of daily digital activities. Without an understanding of the digital economy, recommending the use of technology to patients with mental illness can inadvertently lead to harm. Behavioral data are sold in the secondary data market, combined with other data from many sources, and used in algorithms that automatically classify people...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28155205/a-pilot-study-to-determine-whether-combinations-of-objectively-measured-activity-parameters-can-be-used-to-differentiate-between-mixed-states-mania-and-bipolar-depression
#6
Jan Scott, Arne E Vaaler, Ole Bernt Fasmer, Gunnar Morken, Karoline Krane-Gartiser
BACKGROUND: Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studies that assessed activity parameters reported only mean levels rather than complexity or predictability of activity. We identified cases presenting in one of three acute phases of bipolar disorder and examined whether the application of non-linear dynamic models to the description of objectively measured activity can be used to predict case classification...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28155204/a-systematic-review-of-the-frequency-and-severity-of-manic-symptoms-reported-in-studies-that-compare-phenomenology-across-children-adolescents-and-adults-with-bipolar-disorders
#7
REVIEW
Faye Ryles, Thomas D Meyer, Jaime Adan-Manes, Iain MacMillan, Jan Scott
BACKGROUND: In the last two decades, there has been a significant increase in the diagnosis of Bipolar Disorder (BD) in children. The notion of prepubertal onsets of BD is not without controversy, with researchers debating whether paediatric cases have a distinct symptom profile or follow a different illness trajectory from other forms of BD. The latter issue is difficult to address without long-term prospective follow-up studies. However, in the interim, it is useful to consider the phenomenology observed in groups of cases with different ages of onset and particularly to compare manic symptoms in children diagnosed with BD compared to cases presenting with BD in adolescence and adulthood...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28155203/pilot-study-of-a-culturally-adapted-psychoeducation-cape-intervention-for-bipolar-disorder-in-pakistan
#8
Muhammad Ishrat Husain, Imran B Chaudhry, Raza R Rahman, Munir M Hamirani, Nasir Mehmood, Peter M Haddad, John Hodsoll, Allan H Young, Farooq Naeem, Nusrat Husain
BACKGROUND: Despite the use of maintenance medication, recurrence rates in bipolar affective disorder (BPAD) are high. To date, there are no clinical trials that have investigated the use of psychological interventions in bipolar disorder in Pakistan. AIM: The purpose of the study was to assess the feasibility and acceptability of a culturally adapted bipolar psychoeducation programme (CaPE) in Pakistan. METHODS: Thirty-four euthymic bipolar I and II outpatients were randomized to either 12 weekly sessions of individual psychoeducation plus Treatment As Usual (Intervention) or Treatment As Usual (TAU) (Control)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28124233/american-tertiary-clinic-referred-bipolar-ii-disorder-versus-bipolar-i-disorder-associated-with-hastened-depressive-recurrence
#9
Bernardo Dell'Osso, Saloni Shah, Dennis Do, Laura D Yuen, Farnaz Hooshmand, Po W Wang, Shefali Miller, Terence A Ketter
BACKGROUND: Bipolar disorder (BD) is a chronic, frequently comorbid condition characterized by high rates of mood episode recurrence and suicidality. Little is known about prospective longitudinal characterization of BD type II (BD II) versus type I (BD I) in relation to time to depressive recurrence and recovery from major depressive episode. We therefore assessed times to depressive recurrence/recovery in tertiary clinic-referred BD II versus I patients. METHODS: Outpatients referred to Stanford BD Clinic during 2000-2011 were assessed with Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation and with Clinical Monitoring Form during up to 2 years of naturalistic treatment...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28108944/the-seroprevalence-of-antithyroid-peroxidase-antibodies-in-bipolar-families-and-bipolar-twins-results-from-two-longitudinal-studies
#10
G Snijders, L de Witte, E Mesman, S Kemner, R Vonk, R Brouwer, W A Nolen, H A Drexhage, M H J Hillegers
BACKGROUND: Previous studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence's and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (without a mood disorder) compared to controls, suggesting that TPO-Abs might be considered as vulnerability factor (trait marker) for BD development. OBJECTIVES: Here we elucidate, in the same cohorts, but now after 12- and 6-year follow-up, whether TPO-abs should be considered as a 'trait' marker for BD...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27900735/electronic-monitoring-of-self-reported-mood-the-return-of-the-subjective
#11
REVIEW
Abigail Ortiz, Paul Grof
This narrative review describes recent developments in the use of technology for utilizing the self-monitoring of mood, provides some relevant background, and suggests some promising directions. Subjective experience of mood is one of the valuable sources of information about the state of an integrated mind/brain system. During the past century, psychiatry and psychology moved away from subjectivity, emphasizing external observation, precise measurement, and laboratory techniques. This shift, however, provided only a limited improvement in the understanding of mood disorders, and it appears that self-monitoring of mood has the potential to enrich our knowledge, particularly when combined with the advances in technology...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27900734/lithium-side-effects-and-toxicity-prevalence-and-management-strategies
#12
REVIEW
Michael Gitlin
Despite its virtually universal acceptance as the gold standard in treating bipolar disorder, prescription rates for lithium have been decreasing recently. Although this observation is multifactorial, one obvious potential contributor is the side effect and toxicity burden associated with lithium. Additionally, side effect concerns assuredly play some role in lithium nonadherence. This paper summarizes the knowledge base on side effects and toxicity and suggests optimal management of these problems. Thirst and excessive urination, nausea and diarrhea and tremor are rather common side effects that are typically no more than annoying even though they are rather prevalent...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27873290/aims-and-structure-of-the-german-research-consortium-bipolife-for-the-study-of-bipolar-disorder
#13
REVIEW
Philipp S Ritter, Felix Bermpohl, Oliver Gruber, Martin Hautzinger, Andreas Jansen, Georg Juckel, Tilo Kircher, Martin Lambert, Christoph Mulert, Andrea Pfennig, Andreas Reif, Otto Rienhoff, Thomas G Schulze, Emanuel Severus, Thomas Stamm, Michael Bauer
BACKGROUND: Bipolar disorder is a severe and heterogeneous mental disorder. Despite great advances in neuroscience over the past decades, the precise causative mechanisms at the transmitter, cellular or network level have so far not been unraveled. As a result, individual treatment decisions cannot be tailor-made and the uncertain prognosis is based on clinical characteristics alone. Although a subpopulation of patients have an excellent response to pharmacological monotherapy, other subpopulations have been less well served by the medical system and therefore require more focused attention...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27858348/bipolar-disorder-in-the-digital-age-new-tools-for-the-same-illness
#14
John Torous, Paul Summergrad, S Nassir Ghaemi
"Nothing is more difficult than to ascertain the length of time that a maniacal patient can exist without sleep."-Dr. Sutherland (Br J Psychiatry 7(37):1-19, 1861). Dr. Sutherland's patient was suffering from an acute manic episode, which today is called bipolar illness. 150 years later, we continue to struggle with the same challenges in ascertaining accurate symptoms from patients. In era of new digital tools, the quantified self-movement, and precision medicine, we can ask the question: Can we advance understanding and treatment for bipolar illness beyond asking the same questions as in 1861?...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27858347/serum-concentrations-of-mood-stabilizers-are-associated-with-memory-but-not-other-cognitive-domains-in-psychosis-spectrum-disorders-explorative-analyses-in-a-naturalistic-setting
#15
Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni Mørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset, Ole A Andreassen
BACKGROUND: Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spectrum. We studied the association between serum concentration of mood stabilizers and cognitive performance in a well-characterized sample of bipolar and schizophrenia spectrum disorders. METHODS: Serum concentrations of valproate, lamotrigine, and lithium were analyzed for associations to performance on neuropsychological tests in six cognitive domains in individuals with bipolar disorder (n = 167) and in a combined sample of individuals with bipolar or schizophrenia spectrum disorders (n = 217)...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27837521/bipolar-disorder-in-children-and-adolescents-diagnostic-inpatient-rates-from-2000-to-2013-in-germany
#16
Pradeep Rao, Julie K Moore, Richard Stewart, Kevin Runions, Natasha Bear, Janice W Y Wong, Martin Holtmann, Florian D Zepf
BACKGROUND: Despite growing consensus on nosology and epidemiology of bipolar disorder (BD) in minors, differences remain. We contribute to this discussion by measuring long-term trends in the inpatient discharge rates of BD in minors. METHODS: Nationwide German inpatient discharge diagnoses of BD and other related psychiatric disorders were mapped between 2008 and 2013 using registry data from the German Federal Health Monitoring System. This was compared with previously published data, 2000-2007, to assess long-term trends in diagnosis of BD at discharge...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27757849/psychometric-properties-and-validation-of-a-four-item-version-of-the-strauss-carpenter-scale-in-bipolar-disorder
#17
Susana Alberich, Sara Barbeito, Itxaso González-Ortega, Amaia Ugarte, Patricia Vega, Sonia Ruiz de Azúa, Purificación López, Iñaki Zorrilla, Ana González-Pinto
BACKGROUND: Bipolar disorder is a chronic illness that impairs functioning and affects the quality of life of patients. The onset of this illness usually occurs at an early age, and the risk of relapse remains high for decades. Thus, due to the great clinical relevance of identifying long-term predictors of functioning in bipolar disorder, Strauss and Carpenter developed a scale composed of items known to have prognostic value. METHODS: To determine the clinical usefulness of the four-item Strauss-Carpenter scale in bipolar disorder, a 1-year prospective follow-up study was carried out...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27734417/symptom-profiles-and-illness-course-among-anabaptist-and-non-anabaptist-adults-with-major-mood-disorders
#18
Kelly E Gill, Stephanie A Cardenas, Layla Kassem, Thomas G Schulze, Francis J McMahon
BACKGROUND: Anabaptists comprise large and growing Amish and Mennonite populations with a unique genetic heritage and cultural background. Little is known about the symptoms and course of major mood disorders in Anabaptists. Even less is known about the impact of potential moderators on symptom severity and course. METHODS: A sample of Amish and Mennonite participants with bipolar, recurrent unipolar, or schizoaffective bipolar disorder (n = 155) were systematically evaluated with a well-validated instrument...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27734416/no-differences-in-visual-theory-of-mind-abilities-between-euthymic-bipolar-patients-and-healthy-controls
#19
Silvia Haag, Paula Haffner, Esther Quinlivan, Martin Brüne, Thomas Stamm
BACKGROUND: Research on theory of mind (ToM) abilities in patients with bipolar disorder has yielded conflicting results. Meta-analyses point to a stable moderate impairment in remitted patients, but factors such as subsyndromal symptoms, illness severity, and deficits in basic neurocognitive functions might act as confounders. Also, differences in deficits depending on task area (cognitive or affective) or task modality (visual or verbal) have been observed. This study aimed to test the hypothesis that euthymic bipolar patients would perform more poorly than healthy subjects on visual cognitive and visual affective ToM tasks...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27613276/is-treatment-for-bipolar-disorder-more-effective-earlier-in-illness-course-a-comprehensive-literature-review
#20
REVIEW
Katie Joyce, Andrew Thompson, Steven Marwaha
BACKGROUND: We aimed to investigate a key element of the early intervention approach whether treatment at an earlier stage of bipolar disorder is more effective than later in its course. METHODS: A comprehensive literature review using Medline, Embase, Psychinfo, PsycArticle, and Web of Science, as data sources, with a subsequent narrative synthesis. Study quality was assessed using the Cochrane risk of bias method. RESULTS: Our search strategy yielded eight primary papers and two meta-analyses (of psychological therapies and Olanzapine) in total representing 8942 patients...
December 2016: International Journal of Bipolar Disorders
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