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International Journal of Bipolar Disorders

Susana Alberich, Sara Barbeito, Itxaso González-Ortega, Amaia Ugarte, Patricia Vega, Sonia Ruiz de Azúa, Purificación López, Iñaki Zorrilla, Ana González-Pinto
BACKGROUND: Bipolar disorder is a chronic illness that impairs functioning and affects the quality of life of patients. The onset of this illness usually occurs at an early age, and the risk of relapse remains high for decades. Thus, due to the great clinical relevance of identifying long-term predictors of functioning in bipolar disorder, Strauss and Carpenter developed a scale composed of items known to have prognostic value. METHODS: To determine the clinical usefulness of the four-item Strauss-Carpenter scale in bipolar disorder, a 1-year prospective follow-up study was carried out...
December 2016: International Journal of Bipolar Disorders
Kelly E Gill, Stephanie A Cardenas, Layla Kassem, Thomas G Schulze, Francis J McMahon
BACKGROUND: Anabaptists comprise large and growing Amish and Mennonite populations with a unique genetic heritage and cultural background. Little is known about the symptoms and course of major mood disorders in Anabaptists. Even less is known about the impact of potential moderators on symptom severity and course. METHODS: A sample of Amish and Mennonite participants with bipolar, recurrent unipolar, or schizoaffective bipolar disorder (n = 155) were systematically evaluated with a well-validated instrument...
December 2016: International Journal of Bipolar Disorders
Silvia Haag, Paula Haffner, Esther Quinlivan, Martin Brüne, Thomas Stamm
BACKGROUND: Research on theory of mind (ToM) abilities in patients with bipolar disorder has yielded conflicting results. Meta-analyses point to a stable moderate impairment in remitted patients, but factors such as subsyndromal symptoms, illness severity, and deficits in basic neurocognitive functions might act as confounders. Also, differences in deficits depending on task area (cognitive or affective) or task modality (visual or verbal) have been observed. This study aimed to test the hypothesis that euthymic bipolar patients would perform more poorly than healthy subjects on visual cognitive and visual affective ToM tasks...
December 2016: International Journal of Bipolar Disorders
Katie Joyce, Andrew Thompson, Steven Marwaha
BACKGROUND: We aimed to investigate a key element of the early intervention approach whether treatment at an earlier stage of bipolar disorder is more effective than later in its course. METHODS: A comprehensive literature review using Medline, Embase, Psychinfo, PsycArticle, and Web of Science, as data sources, with a subsequent narrative synthesis. Study quality was assessed using the Cochrane risk of bias method. RESULTS: Our search strategy yielded eight primary papers and two meta-analyses (of psychological therapies and Olanzapine) in total representing 8942 patients...
December 2016: International Journal of Bipolar Disorders
Kristen A Schmidt, Brian A Palmer, Mark A Frye
BACKGROUND: This case chronicles the unique presentation of psychotic mixed mania in a female 5 months after parturition and 1 week following breastfeeding discontinuation, highlighting a rarely recognized mania risk factor that is temporally delayed from parturition: breastfeeding discontinuation. CASE PRESENTATION: A 25-year-old G1P1 female with a past psychiatric history of a depressive episode in adolescence presented to the Emergency Department with her 5-month-old daughter, fiancée, and family 1 week after breastfeeding cessation...
December 2016: International Journal of Bipolar Disorders
Jörn Conell, Rita Bauer, Tasha Glenn, Martin Alda, Raffaella Ardau, Bernhard T Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Letizia Bossini, Angela Marianne Paredes Castro, Eric Yat Wo Cheung, Caterina Chillotti, Sabine Choppin, Maria Del Zompo, Rodrigo Dias, Seetal Dodd, Anne Duffy, Bruno Etain, Andrea Fagiolini, Julie Garnham, John Geddes, Jonas Gildebro, Ana Gonzalez-Pinto, Guy M Goodwin, Paul Grof, Hirohiko Harima, Stefanie Hassel, Chantal Henry, Diego Hidalgo-Mazzei, Vaisnvy Kapur, Girish Kunigiri, Beny Lafer, Chun Lam, Erik Roj Larsen, Ute Lewitzka, Rasmus Licht, Anne Hvenegaard Lund, Blazej Misiak, Patryk Piotrowski, Scott Monteith, Rodrigo Munoz, Takako Nakanotani, René E Nielsen, Claire O'Donovan, Yasushi Okamura, Yamima Osher, Andreas Reif, Philipp Ritter, Janusz K Rybakowski, Kemal Sagduyu, Brett Sawchuk, Elon Schwartz, Ângela Miranda Scippa, Claire Slaney, Ahmad Hatim Sulaiman, Kirsi Suominen, Aleksandra Suwalska, Peter Tam, Yoshitaka Tatebayashi, Leonardo Tondo, Eduard Vieta, Maj Vinberg, Biju Viswanath, Julia Volkert, Mark Zetin, Iñaki Zorrilla, Peter C Whybrow, Michael Bauer
BACKGROUND: Information seeking is an important coping mechanism for dealing with chronic illness. Despite a growing number of mental health websites, there is little understanding of how patients with bipolar disorder use the Internet to seek information. METHODS: A 39 question, paper-based, anonymous survey, translated into 12 languages, was completed by 1222 patients in 17 countries as a convenience sample between March 2014 and January 2016. All patients had a diagnosis of bipolar disorder from a psychiatrist...
December 2016: International Journal of Bipolar Disorders
Elisa Sophie Strasser, Paula Haffner, Jana Fiebig, Esther Quinlivan, Mazda Adli, Thomas Josef Stamm
BACKGROUND: Impulsivity as a tendency to act quickly without considering future consequences has been proposed as a dimensional factor in bipolar disorder. It can be measured using behavioral tasks and self-report questionnaires. Previous findings revealed patients to show worse performance on at least one behavioral measure of impulsivity. Additionally, self-reported impulsivity seems to be higher among bipolar patients, both parameters being possibly associated with a more severe course of illness...
December 2016: International Journal of Bipolar Disorders
Laura D Yuen, Saloni Shah, Dennis Do, Shefali Miller, Po W Wang, Farnaz Hooshmand, Terence A Ketter
BACKGROUND: Current irritability is associated with greater retrospective and current bipolar disorder (BD) illness severity; less is known about prospective longitudinal implications of current irritability. We examined relationships between current irritability and depressive recurrence and recovery in BD. METHODS: Outpatients referred to the Stanford BD Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation at baseline, and with the Clinical Monitoring Form during follow-up during up to 2 years of naturalistic treatment...
December 2016: International Journal of Bipolar Disorders
Sonya M Balukova, Bartholomeus C M Haarman, Rixt F Riemersma-van der Lek, Robert A Schoevers
BACKGROUND: The association between inflammation and the course of mood disorders is receiving increased attention. This study aims to investigate whether a sub-group of patients with BD can be identified for which a higher CRP (C-reactive protein) level at baseline is associated with an unfavorable prognosis. METHODS: This is a historic cohort study using CRP at baseline, with 15-month follow-up of mood status and medication. Cross-sectional analyses include boxplots, one-way ANOVA, receiver operating characteristics (ROC) curve and Chi square test, and the longitudinal analysis using multivariate Cox-regression...
December 2016: International Journal of Bipolar Disorders
Ellen F Charles, Christophe G Lambert, Berit Kerner
BACKGROUND: Bipolar disorder refers to a group of chronic psychiatric disorders of mood and energy levels. While dramatic psychiatric symptoms dominate the acute phase of the diseases, the chronic course is often determined by an increasing burden of co-occurring medical conditions. High rates of diabetes mellitus in patients with bipolar disorder are particularly striking, yet unexplained. Treatment and lifestyle factors could play a significant role, and some studies also suggest shared pathophysiology and risk factors...
December 2016: International Journal of Bipolar Disorders
Sarah M Goodday, Julie Horrocks, Charles Keown-Stoneman, Paul Grof, Anne Duffy
BACKGROUND: Differences in cortisol secretion may differentiate individuals at high compared to low genetic risk for bipolar disorder (BD) and predict the onset or recurrence of mood episodes. The objectives of this study were to determine if salivary cortisol measures are: (1) different in high-risk offspring of parents with BD (HR) compared to control offspring of unaffected parents (C), (2) stable over time, (3) associated with the development of mood episode onset/recurrence, and (4) influenced by comorbid complications...
December 2016: International Journal of Bipolar Disorders
José Oliveira, Rémi Kazma, Edith Le Floch, Meriem Bennabi, Nora Hamdani, Djaouida Bengoufa, Mehdi Dahoun, Céline Manier, Frank Bellivier, Rajagopal Krishnamoorthy, Jean-François Deleuze, Robert Yolken, Marion Leboyer, Ryad Tamouza
BACKGROUND: Genetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem disorder in which immune dysfunction and infectious insults seem to play a major role in the pathophysiology. Association between pattern-recognition receptor coding genes and BD had been previously reported. However, potential interactions with history of pathogen exposure are yet to be explored. METHODS: 138 BD patients and 167 healthy controls were tested for serostatus of Toxoplasma gondii, CMV, HSV-1 and HSV-2 and genotyped for TLR2 (rs4696480 and rs3804099), TLR4 (rs1927914 and rs11536891) and NOD2 (rs2066842) polymorphisms (SNPs)...
December 2016: International Journal of Bipolar Disorders
Scott Monteith, Tasha Glenn, John Geddes, Peter C Whybrow, Michael Bauer
The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are big data and advances in the ability to analyze these data. The impact of big data on the routine treatment of bipolar disorder today and in the near future is discussed, with examples that relate to health policy, the discovery of new associations, and the study of rare events. The primary sources of big data today are electronic medical records (EMR), claims, and registry data from providers and payers...
December 2016: International Journal of Bipolar Disorders
Lauren E Cudney, Benicio N Frey, David L Streiner, Luciano Minuzzi, Roberto B Sassi
BACKGROUND: Evidence suggests that patients with bipolar disorder (BD) experience biological rhythm disturbances; however, no studies have examined the impact of this disruption on quality of life (QOL). The aim of this study is to investigate the influence of biological rhythm, depressive symptoms, sleep quality, and sleep medication use on QOL in BD. METHODS: Eighty BD subjects (44 depressed and 36 euthymic) completed questionnaires assessing QOL (WHOQOL-BREF), biological rhythm disruption (BRIAN), depressive symptoms (MADRS), and sleep quality (PSQI)...
December 2016: International Journal of Bipolar Disorders
Norm O'Rourke, Andrew Sixsmith, David B King, Hamed Yaghoubi-Shahir, Sarah L Canham
OBJECTIVES: Ecological momentary sampling in BD research requires brief symptom measures with low cognitive demands to maximize data collection across the range of BD symptomatology. We developed the BD Sx cognizant of the challenges inherent in scale development with low prevalence populations and the limitations of existing measures (e.g., over-reliance on patients in acute states recruited from psychiatric settings). In order to be generalizable across the full spectrum of the illness, we also included those currently euthymic and those who avoid clinical contact...
December 2016: International Journal of Bipolar Disorders
Krithika Rajagopalan, Elizabeth Dansie Bacci, Kathleen W Wyrwich, Andrei Pikalov, Antony Loebel
BACKGROUND: Bipolar depression is characterized by depressive symptoms and impairment in many areas of functioning, including work, family, and social life. The objective of this study was to assess the independent, direct effect of lurasidone treatment on functioning improvement, and examine the indirect effect of lurasidone treatment on functioning improvement, mediated through improvements in depression symptoms. METHODS: Data from a 6-week placebo-controlled trial assessing the effect of lurasidone monotherapy versus placebo in patients with bipolar depression was used...
December 2016: International Journal of Bipolar Disorders
Alejandro Szmulewicz, Cecilia Samamé, Pablo Caravotta, Diego J Martino, Ana Igoa, Diego Hidalgo-Mazzei, Francesc Colom, Sergio A Strejilevich
BACKGROUND: Behavioral and emotional adverse events induced by drugs commonly prescribed to patients with bipolar disorders are of paramount importance to clinical practice and research. However, no reviews on the topic have been published so far. METHODS: An extensive search was performed. Reports were reviewed if they described behavioral side effects related to pharmacological treatments for bipolar disorders in healthy subjects or patients with different neuropsychiatric disorders...
December 2016: International Journal of Bipolar Disorders
Alberto Bocchetta, Francesco Traccis, Enrica Mosca, Alessandra Serra, Giorgio Tamburini, Andrea Loviselli
Mood disorders and circulating thyroid antibodies are very prevalent in the population and their concomitant occurrence may be due to chance. However, thyroid antibodies have been repeatedly hypothesized to play a role in specific forms of mood disorders. Potentially related forms include treatment-refractory cases, severe or atypical depression, and depression at specific phases of a woman's life (early gestation, postpartum depression, perimenopausal). With regard to bipolar disorder, studies of specific subgroups (rapid cycling, mixed, or depressive bipolar) have reported associations with thyroid antibodies...
December 2016: International Journal of Bipolar Disorders
Erin E Michalak, Steven Jones, Fiona Lobban, Guillermo Perez Algorta, Steven J Barnes, Lesley Berk, Michael Berk, Rachelle Hole, Sara Lapsley, Victoria Maxwell, Roumen Milev, John McManamy, Greg Murray, Mauricio Tohen, Samson Tse, Manuel Sanchez de Carmona, Sheri L Johnson
BACKGROUND: Despite the rapid growth in the sophistication of research on bipolar disorder (BD), the field faces challenges in improving quality of life (QoL) and symptom outcomes, adapting treatments for marginalized communities, and disseminating research insights into real-world practice. Community-based participatory research (CBPR)-research that is conducted as a partnership between researchers and community members-has helped address similar gaps in other health conditions. This paper aims to improve awareness of the potential benefits of CBPR in BD research...
December 2016: International Journal of Bipolar Disorders
Ashlee B Grierson, Ian B Hickie, Sharon L Naismith, Daniel F Hermens, Elizabeth M Scott, Jan Scott
BACKGROUND: Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders. METHODS: Actigraphy was undertaken for about 14 days in 63 post-pubertal individuals aged 13-25 years with a recent onset of a mood disorder meeting recognised diagnostic criteria...
December 2016: International Journal of Bipolar Disorders
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