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Journal of Global Antimicrobial Resistance

Azar Shokri, Mahdi Abastabar, Masoud Keighobadi, Saeed Emami, Mahdi Fakhar, Saeed Hosseini Teshnizi, Koichi Makimura, Ali Rezaei-Matehkolaei, Hassan Mirzaei
OBJECTIVES: Pentavalent antimonials have been used for the treatment of leishmaniasis for more than 70 years; however their toxicity limits their benefits. Unfortunately, the efficacy of the first line drugs has been decreased and resistance seems to be noticeable. Luliconazole is a new azole with unique effects on fungi which has not been tested on Leishmania parasites yet. METHODS: In the present study, we evaluated cytotoxicity and anti-leishmanial activities of Luliconazole on promastigotes and intracellular amastigotes of Leishmania major (L...
May 21, 2018: Journal of Global Antimicrobial Resistance
Claudia Barberis, Eugenia Sandoval, Carlos Hernán Rodriguez, María Soledad Ramírez, Angela Famiglietti, Marisa Almuzara, Carlos Vay
INTRODUCTION: Although Corynebacterium species are part of the skin and mucous membranes microbiota, human infections caused by Corynebacterium spp. have been reported and the multidrug resistance pattern of the recovered isolates was emphasized. Due to the usefulness of disk diffusion in daily practice, the purpose of this work was to compare disk diffusion against agar dilution to determine disk diffusion breakpoints and to review the antimicrobial susceptibility of the most frequent Corynebacterium spp...
May 18, 2018: Journal of Global Antimicrobial Resistance
Varsha Rani Gajamer, Amitabha Bhattacharjee, Deepjyoti Paul, Chandrayee Deshamukhya, Ashish Kr Singh, Nilu Pradhan, Hare Krishna Tiwari
OBJECTIVES: Carbapenemase-producing Escherichia coli are of major clinical concern. The present study aimed to identify NDM-5 producing E.coli associated with community-acquired urinary tract infection, co-harboring ESBL genes and a pattern of imipenem MIC creep. METHODS: A total of 973 urine samples were collected from females of age between 18-49 diagnosed with UTI. Isolates were identified by standard microbiological procedures. Presence of blaNDM and ESBL genes was determined by PCR assay and sequencing...
May 15, 2018: Journal of Global Antimicrobial Resistance
Gengmi Li, Li Yang, Tao Zhang, Xiaojiao Guo, Jian Qin, Yingjiang Cao, Qianhua Yang, Shumei You, Guoliang Yuan, Xianqi Wan, Jing Luo, Zhaoxiang Li, Lei Gao, Ying Liu, Kaifeng Jiang, Jiakui Zheng
OBJECTIVES: Achromobacter spanius is a new described, non-fermenting Gram-negative and coccoid pathogen that isolated from patient blood. In order to investigate the pathogenesis of this strain in genomic level, whole genome sequencing was carried out on this strain. METHODS: In this study, complete genome of the type strain of this species DSM 23806T was sequenced using single-molecule real-time (SMRT) DNA sequencing. RESULTS: Complete genome of DSM 23806T consists of one circular DNA chromosome of 6,425,783bp with a GC content of 64...
May 15, 2018: Journal of Global Antimicrobial Resistance
Yamuna Devi Bakthavatchalam, Boopalan Ramaswamy, Rajinikanth Janakiraman, Runal John Steve, Balaji Veeraraghavan
OBJECTIVE: Glycopeptides are being increasingly used to multi-resistant MRSA infections. We report MRSA with low level teicoplanin resistance recovered from a patient treated with teicoplanin for fatal necrotizing fasciitis. PATIENT AND METHODS: MRSA recovered from a patient with necrotizing fasciitis was treated with teicoplanin. The minimum inhibitory concentration (MIC) for vancomycin and teicoplanin was determined using E-test. Reduced glycopeptide susceptibility was screened using GRD E-test and population analysis profile (PAP) method...
May 15, 2018: Journal of Global Antimicrobial Resistance
Piergiorgio Cojutti, Assunta Sartor, Matteo Bassetti, Claudio Scarparo, Federico Pea
OBJECTIVE: To assess MIC distribution for meropenem and the other antibiotics with Gram-negative activity against KPC-Kp clinical isolates collected at our hospital in 2013-2016. METHODS: Susceptibility of KPC-Kp strains was tested by broth microdilution method, using customized 96-well plates, and was interpreted according to the EUCAST recommendations. RESULTS: Among 169 consecutive KPC-Kp clinical isolates 26.6% were susceptible to meropenem...
May 15, 2018: Journal of Global Antimicrobial Resistance
Muhammad Ibrahim, Asma Muhammad Yar, Ghunva Zaman, Changhui Yan, Muhammad Khurshid, Habib Bokhari
OBJECTIVES: Multidrug resistant Mycobacterium tuberculosis poses a global threat, particularly in developing countries such as Pakistan. Genome sequencing, comparative genomic analysis, and drug resistance gene analysis, could be beneficial for understanding and monitoring M. tuberculosis disease severity in Pakistan by elucidating the biology of M. tuberculosis. METHODS: In this study, we sequenced, assembled, and annotated a draft genome of M. tuberculosis strain swlpk using the Illumina MiSeq 300PE throughput 2M system...
May 12, 2018: Journal of Global Antimicrobial Resistance
Marco André Tonini, Julianne Soares Jardim Lacerda Batista, Luciana Bueno Freitas, Mirla Borghi, Myriam Santos Almeida, Liliana Cruz Spano, Ricardo Pinto Schuenck
No abstract text is available yet for this article.
May 10, 2018: Journal of Global Antimicrobial Resistance
Jessica Baleiro Okado, Juliana Sposto Avaca-Crusca, Alexandre Lima Oliveira, Andrei Nicoli Gebieluca Dabul, Ilana Lopes Baratella da Cunha Camargo
INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) is a threat to clinical treatment. Besides high resistance, presence of heterogeneous vancomycin intermediate S. aureus (hVISA) and heterogeneous daptomycin non-susceptible S. aureus (hDNSSA) in the hospital environment are underestimated and associated with treatment failure. OBJECTIVES: To investigate a MRSA dissemination in a Brazilian hospital and to evaluate the efficacy of some treatment options in vitro...
May 9, 2018: Journal of Global Antimicrobial Resistance
Bulent Durdu, Evangelos I Kritsotakis, Andrew C K Lee, Perihan Torun, Ismail N Hakyemez, Bilge Gultepe, Turan Aslan
OBJECTIVES: This study assessed trends and patterns in antimicrobial resistant intensive care unit (ICU)-acquired infections caused by Gram-negative bacteria (GNB) in Istanbul, Turkey. METHODS: Bacterial culture and antibiotic susceptibility data were collected for all GNB causing nosocomial infections in five adult ICUs of a large university hospital during 2012-2015. Multi-resistance patterns were categorised as multidrug (MDR), extensively-drug (XDR) and pandrug (PDR)-resistance...
May 8, 2018: Journal of Global Antimicrobial Resistance
Mehdi Mirzaii, Sanaz Jamshidi, Maryam Zamanzadeh, Masoud Marashifard, Seyed Ali Asghar Malek Hosseini, Mehri Haeili, Fariba Jahanbin, Fariba Mansouri, Davood Darban-Sarokhalil, Seyed Sajjad Khoramrooz
BACKGROUND: Fluoroquinolones (FQs) are recommended as the drug of choice for the empirical treatment of urinary tract infections (UTIs).We aimed to investigate the molecular determinants of FQ resistance in Escherichia coli and Klebsiella pneumoniae isolates. METHODS: A total of 364 clinical isolates of E. coli (n=144) and K. pneumoniae (n=220) were collected from patients with UTI. Susceptibility of the isolates to ciprofloxacin, levofloxacin, gatifloxacin and nalidixic acid was evaluated by using disc diffusion method...
May 7, 2018: Journal of Global Antimicrobial Resistance
Carolina Monteiro, Miguel A Faria, Dolores Pinheiro, Catarina Lameiras, Eugénia Pinto
No abstract text is available yet for this article.
May 7, 2018: Journal of Global Antimicrobial Resistance
Bo Zhu, Chaoqun Ying, Hao Xu, Jingjing Ying
OBJECTIVES: Although blaNDM-1 has now been widely detected in various Enterobacteriaceae clinical isolates, multiple blaNDM-1 colonizations within the same patient remain rare. The aim of the study was to describe a patient with respiratory tract colonization of NDM-1-producing Escherichia coli and Citrobacter freundii during a hospitalization in China. METHODS: Two carbapenem-resistant isolates were analysed. Susceptibility testing, metallo-β-lactamase production, conjugation, plasmid analysis, and molecular typing were performed...
May 1, 2018: Journal of Global Antimicrobial Resistance
Nívea Pereira de Sá, Lídia Fátima José de Paula, Larissa Ferreira Finamore Lopes, Lana Ivone Barreto Cruz, Thelma Tirone Silvério Matos, Cleudiomar Inácio Lino, Renata Barbosa de Oliveira, Elaine Maria de Souza-Fagundes, Beth Burgwyn Fuchs, Eleftherios Mylonakis, Susana Johann
OBJECTIVES: Candida albicans is a commensal pathogen associated with both superficial (mucosal and cutaneous) and systemic infections. The extensive use of antifungal agents has led to reduced susceptibility to the few existing drugs. This situation has encouraged the search for novel antifungal agents. Therefore, in the present study, we investigated the antifungal activity of 2,6-bis[(E)-(4-pyridyl)methylidene]cyclohexanone (PMC). METHODS: We evaluated its in vitro activity against C...
April 28, 2018: Journal of Global Antimicrobial Resistance
Diego Faccone, Celeste Lucero, Ezequiel Albornoz, Alejandro Petroni, Paola Ceriana, Josefina Campos, María Rosa Viñas, Geraldine Francis, Roberto G Melano, Alejandra Corso
No abstract text is available yet for this article.
April 26, 2018: Journal of Global Antimicrobial Resistance
Maricarmen Iñiguez-Moreno
OBJECTIVES: The effectiveness of disinfectants can vary according to the microorganism, type of residues and surface. Hence, the aim of this study was to determine the effectiveness of four disinfectants in the presence of organic matter and their residual effect on stainless steel grade 304 (SS) and polypropylene B (PP-B). METHODS: The disinfectant effectiveness in the presence of meat extract, yolk egg and whole milk was determined according to AOAC and UNE-EN 1040:2015; the residual effect was realized according to UNE-EN 13697:2015, using approved strains...
April 23, 2018: Journal of Global Antimicrobial Resistance
D K Singh, Bablu Kumar, Garima Shrinet, R P Singh, Aparajita Das, B G Mantur, Abhishek, Aruna Pandey, Piyali Mondal, B K Sajjanar, Soni Doimari, Vijayata Singh, Reena Kumari, A K Tiwari, Gandham Ravikumar
OBJECTIVES: Brucellosis, is among one of the most widespread important global zoonotic diseases which is endemic in many parts of India. Brucella melitensis is supposed to be the most pathogenic species for humans. Here, we report draft genome sequence of B. melitensis strain 2007BM/1 isolated from human in India. METHODS: Genomic DNA was extracted from Brucella culture and was sequenced using an Illumina MiSeq platform. The generated reads were assembled using three de novo assemblers and the draft genome was annotated...
April 20, 2018: Journal of Global Antimicrobial Resistance
Rasha M Elkenany, Abdelfattah H Eladl, Reham A El-Shafei
BACKGROUND: The antibiotic resistance of Salmonella serovars is recorded and the integrons play an important role in the dissemination of antibiotic resistance genes in bacteria. Little literatures are available on the recognition of integrons in isolated Salmonella from broiler chickens. OBJECTIVES: In this study, antibiotic resistance and characterization of class 1 (Cls1) integrons among Multidrug resistance serovars of Salmonella enterica in broiler chicken farms were performed...
April 20, 2018: Journal of Global Antimicrobial Resistance
Zhiwei Zheng, Ruichao Li, Marcus Ho-Yin Wong, Edward Wai-Chi Chan, Xiaodong Xia, Sheng Chen
No abstract text is available yet for this article.
April 18, 2018: Journal of Global Antimicrobial Resistance
Xi Li, Long Sun, Yongze Zhu, Mengyuan Shen, Yuexing Tu
OBJECTIVES: The emergence of Carbapenem-resistant E. coli has become a serious challenge to manage in the clinic because of multi-drug resistance. Here, we report the draft genome sequence of a NDM-3-producing E. coli strain NT1 that was isolated from bloodstream infection in China. METHODS: Whole-genomic DNA of E. coli strain NT1 was extracted and was sequenced using an Illumina-Hiseq™ X Ten platform. The generated sequence reads were assembled using CLC Genomics Workbench...
April 14, 2018: Journal of Global Antimicrobial Resistance
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