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Journal of Global Antimicrobial Resistance

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https://www.readbyqxmd.com/read/29990547/significance-of-catalase-peroxidase-katg-mutations-in-mediating-isoniazid-resistance-in-clinical-strains-of-mycobacterium-tuberculosis
#1
Ameeruddin Nusrath Unissa, George Priya Doss C, Thirumal Kumar, Swathi Sukumar, Appisetty Ramya Lakshmi, Luke Elizabeth Hanna
OBJECTIVES: Isoniazid (INH) is still the most important first-line anti-tuberculosis (TB) drug. Resistance to this drug is regarded as a major impediment on the TB control program and to the emergence of multidrug-resistant strains. Mutations at position 315 in the katG gene which codes for catalase-peroxidase (KatG) enzyme, is the major cause for INH resistance in Mycobacterium tuberculosis (MTB). Therefore, investigation into the molecular mechanisms of INH resistance is the need of the hour...
July 7, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29981456/outbreak-of-hypervirulent-klebsiella-pneumoniae-harboring-bla-vim-2-among-mechanically-ventilated-drug-poisoning-patients-with-high-mortality-outcome-in-iran
#2
Amir Mohammad Ali Tabrizi, Farzad Badmasti, Fereshteh Shahcheraghi, Omid Azizi
OBJECTIVES: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are associated with increased rate of treatment failure and death. Several studies have reported isolates with combined hypervirulent and antibiotics resistance phenotype. METHODS: Herein, we studied molecular characteristics of hypervirulent K. pneumoniae isolated from mechanically ventilated patients admitted to toxicological ICU. String test, antibiotic susceptibility, virulence factors and plasmid replicon typing were carried out...
July 4, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29981455/the-prevalence-of-vancomycin-intermediate-staphylococcus-aureus-in-clinical-isolates-in-iran-a-systematic-review-and-meta-analysis
#3
REVIEW
Neda Baseri, Shahin Najar-Peerayeh, Fahimeh Bagheri Amiri
OBJECTIVES: Vancomycin-Intermediate Staphylococcus aureus (VISA) strains have been reported in many countries around the world and its prevalence is increasing. The incidence of these strains in Iran has been shown in some studies; however, there is no overall estimation of VISA incidence in Iran. The objective of this systematic review was to estimate the total prevalence of VISA strains that reported from Iran. METHODS: A systematic literature review of relevant articles published on "S...
July 4, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29981454/whole-genome-sequencing-of-a-ctx-m-11-encoding-and-quinolone-non-susceptible-klebsiella-pneumoniae-st194-isolated-from-a-hospitalized-dog-in-greece
#4
Fani Chatzopoulou, Georgios Meletis, Giulia Polidoro, Ioannis L Oikonomidis, Irene Dimopoulou, Ilias Mavrovouniotis, Tilemahos L Anagnostou
OBJECTIVES: The emergence and spread of transferable beta-lactamases among the Enterobacteriaceae is a major problem to both human and veterinary medicine and an important contributing factor to the development of multi-drug-resistant bacterial strains. In the present study, we performed the whole genome sequencing of a Klebsiella pneumoniae resistant to first and second generation cephalosporins and non-susceptible to fluoroquinolones, isolated from a urine sample of a hospitalized dog...
July 4, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29969753/antimicrobial-resistance-among-helicobacter-pylori-isolates-in-alaska-2000-2016
#5
Emily Mosites, Dana Bruden, Julie Morris, Alisa Reasonover, Karen Rudolph, Debra Hurlburt, Thomas Hennessy, Brian McMahon, Michael Bruce
OBJECTIVES: Alaska Native people experience a high burden of Helicobacter pylori infection and concomitant high rates of gastric cancer. Additionally, the prevalence of antimicrobial resistant strains of H. pylori has been shown to be high in Alaska. We evaluated antimicrobial resistance over time among sentinel surveillance isolates and assessed risk factors for carrying resistant H. pylori. METHODS: Through Alaska's H. pylori sentinel surveillance system, we collected and cultured antral and fundal biopsies from Alaska Native patients undergoing esophagogastroduodenoscopy for clinical indications during 2000-2016...
June 30, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29969752/absence-of-fosfomycin-resistance-in-gastrointestinal-escherichia-coli-after-fosfomycin-therapy
#6
LETTER
Roberta T Mettus, Sarah L Bowler, Serena F Kantz, Christi L Mcelheny, A William Pasculle, Yohei Doi
No abstract text is available yet for this article.
June 30, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29969751/micafungin-use-in-a-uk-tertiary-referral-hospital
#7
David A Enoch, Michael E Murphy, Christianne Micallef, Huina Yang, Nicholas M Brown, Sani H Aliyu
OBJECTIVE: We sought to describe the real-life usage of micafungin in our hospital. METHODS: We performed a prospective non-interventional observational surveillance study in a large teaching hospital. RESULTS: We commenced micafungin in 174 courses involving 148 patients to treat invasive candidiasis and candidaemia (131 courses) and aspergillosis in situations where alternatives such as voriconazole or liposomal amphotericin B could not be used (42 courses)...
June 30, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29966702/oqxab-and-variants-of-qepa-in-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-hospital-wastewater-in-mali
#8
LETTER
Aminata Maiga, Anaëlle Muggeo, Matthieu Daragon, Ibrahim Maiga, Lucien Brasme, Véronique Vernet-Garnier, Mireille Dosso, Christophe de Champs, Thomas Guillard
No abstract text is available yet for this article.
June 29, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29966701/draft-genome-sequences-of-two-ciprofloxacin-resistant-salmonella-enterica-subsp-enterica-serovar-kentucky-st198-isolated-from-retail-chicken-carcasses-in-egypt
#9
Hazem Ramadan, Sushim K Gupta, Poonam Sharma, Khalid I Sallam, Lari M Hiott, Hagar Elsayed, John B Barrett, Jonathan G Frye, Charlene R Jackson
OBJECTIVES: Salmonella enterica serovars, particularly drug resistant strains, pose major threats to public health worldwide. This study describes the draft genome sequences of two ciprofloxacin-resistant Salmonella enterica serovar Kentucky recovered from chicken carcass rinsates in Mansoura, Egypt. METHODS: Antimicrobial resistance phenotypes were determined for the two Salmonella Kentucky by broth microdilution using the Sensititre™ system. Genomic DNA from both isolates was sequenced using the Illumina MiSeq...
June 29, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29964206/incu-plasmid-harbouring-bla-ctx-m-8-in-multidrug-resistant-shigella-sonnei-in-brazil
#10
LETTER
Amanda Aparecida Seribelli, Anelise Stella Ballaben, Joseane Cristina Ferreira, Marta Inês Cazentini Medeiros, Ana Lúcia Costa Darini, Juliana Pfrimer Falcao
No abstract text is available yet for this article.
June 28, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29944920/draft-genome-sequence-of-a-blacmy-2-inci1-harboring-escherichia-coli-d-st457-isolated-from-coastal-benthic-organisms
#11
Fábio P Sellera, Miriam R Fernandes, Quézia Moura, Ralf B Lopes, Tiago A Souza, Louise Cerdeira, Nilton Lincopan
INTRODUCTION: Marine bivalves can act as bioindicators of marine environment pollution by multidrug-resistant enteric bacteria of medical interest. OBJECTIVE: To report the draft genome sequence of a pAmpC (CMY-2)-carrying Escherichia coli isolate recovered from a marine bivalve sample in the coastal shore of Southeast Brazil. METHODS: The whole genome was sequenced on the Illumina NextSeq platform and assembled by using Velvet v. 1.2.10. Data analysis was carried out using tools available from the Center of Genomic Epidemiology and the software Geneious R10...
June 23, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29940334/population-structure-of-oxa-48-producing-klebsiella-pneumoniae-st405-isolates-during-a-hospital-outbreak-characterized-by-genomic-typing
#12
Elena López-Camacho, José Ramón Paño-Pardo, Guillermo Ruiz-Carrascoso, Jan-Jaap Wesselink, Silvia Lusa-Bernal, Ricardo Ramos-Ruiz, Susana Ovalle, Rosa Gómez-Gil, Verónica Pérez-Blanco, María Pérez-Vázquez, Paulino Gómez-Puertas, Jesús Mingorance
OBJECTIVES: To study the structure of a broad and sustained hospital outbreak of OXA-48-producing Klebsiella pneumoniae belonging to ST405. METHODS: Whole-genome sequencing and comparison of ten ST405 isolates obtained from clinical samples in our hospital. Thirty six single nucleotide polymorphisms (SNPs) were detected (range 0 to 21 in pairwise comparisons) and allele-specific PCR was used to call the SNPs among a larger set of isolates. RESULTS: Several haplotypes were identified within the population...
June 22, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29935332/draft-genome-sequencing-of-extended-spectrum-%C3%AE-lactamase-enterobacter-aerogenes-isolates-from-swine-and-human
#13
Luria Leslie Founou, Raspail Carrel Founou, Arshad Ismail, Mushal Allam, Sabiha Yusuf Essack
OBJECTIVES: The draft genome sequences of two Enterobacter aerogenes HN503E2II and PN108E5IIB isolated from two Cameroonian abattoirs, are reported here. METHODS: Genomic DNA of these isolates was sequenced using an Illumina MiSeq platform. Generated reads were de novo assembled using the Qiagen CLC Genomics Workbench. The assembled contigs were annotated and antibiotic resistance genes, virulence factors and plasmids were identified. RESULTS: The whole genome sequencing revealed that both strains are similar with genomes of 4,878,638 and 4,794,257bp and encoded several resistance genes associated with resistance to β-lactams, fluoroquinolones, aminoglycosides, fosfomycin, phenicols, sulphonamides, trimethoprim, macrolide and tetracycline...
June 20, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29935331/prevalence-of-colistin-resistance-gene-mcr-1-in-colistin-resistant-escherichia-coli-and-klebsiella-pneumoniae-isolated-from-humans-in-thailand
#14
Warawan Eiamphungporn, Sakda Yainoy, Chakornpat Jumderm, Rachanis Tan-Arsuwongkul, Surapee Tiengrim, Visanu Thamlikitkul
OBJECTIVES: Colistin has historically been considered a last-line therapeutic option against multidrug-resistant (MDR) Gram-negative bacterial infections. However, chromosomally-encoded and plasmid-mediated colistin resistance is increasingly being reported worldwide. The spread of the plasmid-borne colistin resistance gene mcr-1 is of great concern since it can be transferred among bacteria. The aim of this study was to investigate the prevalence of colistin resistance gene mcr-1 in E...
June 20, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29933119/transcriptomic-study-on-persistence-and-survival-of-listeria-monocytogenes-following-lethal-treatment-with-nisin
#15
Shuyan Wu, Pak-Lam Yu, Dave Wheeler, Steve Flint
OBJECTIVES: The aim of this study was to determine the gene expression associated with the persistence of a Listeria monocytogenes stationary phase population when facing lethal nisin treatment METHODS: RNA Seq analysis was used for gene expression profiling of the persister cells in rich medium (persister TN) compared with untreated cells (non-persister).The results were confirmed using RT PCR. RESULTS: Functional genes associated with the persister populations were identified in multiple systems, such as heat shock related stress response, cell wall synthesis, ATP-binding cassette (ABC) transport system, phosphotransferase system (PTS system), and SOS/DNA repair...
June 19, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29933118/draft-genome-sequence-of-carbapenem-resistant-shewanella-algae-strain-ac-isolated-from-small-abalone-haliotis-diversicolor
#16
Yao-Ting Huang, Jan-Fang Cheng, Shi-Yu Chen, Yu-Kai Hong, Zong-Yen Wu, Po-Yu Liu
OBJECTIVES: Shewanella algae is an environmental marine bacteria and an emerging opportunistic human pathogen. Moreover, there are increasing reports of strains showing multi-drug resistance, particularly carbapenem-resistant isolates. Although S. algae have been found in bivalve shellfish aquaculture, there is very little genome-wide data on resistant determinants in S. algae from shellfish. In the study, we aimed to determine the whole genome sequence of carbapenem-resistant S. algae strain AC isolated from small abalone in Taiwan...
June 19, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29933117/draft-genome-sequence-of-an-extended-spectrum-%C3%AE-lactamase-ctx-m-15-producing-escherichia-coli-st10-isolated-from-a-nasal-sample-of-an-abattoir-worker-in-cameroon
#17
Luria Leslie Founou, Raspail Carrel Founou, Mushal Allam, Arshad Ismail, Sabiha Yusuf Essack
OBJECTIVES: We report here the draft genome sequence of E. coli strain HN503E1II isolated from a nasal sample of an abattoir worker in Cameroon. METHODS: Genomic DNA of E. coli was sequenced using an Illumina MiSeq platform. Generated reads were de novo assembled using the Qiagen CLC Genomics Workbench. The assembled contigs were annotated and antibiotic resistance genes, virulence factors, plasmids and sequence types were identified. RESULTS: The genome comprised a circular chromosome of 4,674,201bp, with a 50...
June 19, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29908916/detection-and-molecular-characterization-of-extended-spectrum-beta-lactamase-producing-enteric-bacteria-from-pigs-and-chickens-in-nsukka-nigeria
#18
Kennedy F Chah, Ifeoma C Ugwu, Angela Okpala, Kwabugge Y Adamu, Carla Andrea Alonso, Sara Ceballos, John N Nwanta, Carmen Torres
OBJECTIVE: To screen chickens and pigs slaughtered for human consumption for presence and characteristics of extended spectrum beta-lactamase (ESBL) and plasmidic AmpC (pAmpC) beta-lactamase-producing enteric bacteria. METHODS: Faecal samples from 410 broiler chickens and 100 pigs were cultured on MacConkey agar supplemented with 2μg/ml cefotaxime. The antibacterial resistance phenotypes of the recovered isolates were determined by disc-diffusion method while PCR and subsequent sequencing was performed to identify the ESBL and pAmpC gene variants and other associated resistance determinants...
June 14, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29906626/a-systematic-review-on-the-use-of-time-series-data-in-the-study-of-antimicrobial-consumption-and-pseudomonas-aeruginosa-resistance
#19
REVIEW
Christos I Athanasiou, Angeliki Kopsini
INTRODUCTION: In the field of antimicrobial resistance, the number of studies that use time series data has increased recently. The purpose of this study is the systematic review of all studies on antibacterial consumption and on Pseudomonas aeruginosa resistance in healthcare settings, that have used time series data. METHODS: A systematic review of the literature till June 2017 was conducted. All the studies that have used time series data and have examined the inhospital antibiotic consumption and Ps...
June 12, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29775788/complete-genome-sequence-of-achromobacter-spanius-type-strain-dsm-23806-t-a-pathogen-isolated-from-human-blood
#20
Gengmi Li, Li Yang, Tao Zhang, Xiaojiao Guo, Jian Qin, Yingjiang Cao, Qianhua Yang, Shumei You, Guoliang Yuan, Xianqi Wan, Jing Luo, Zhaoxiang Li, Lei Gao, Ying Liu, Kaifeng Jiang, Jiakui Zheng
OBJECTIVES: Achromobacter spanius is a newly described, non-fermenting, Gram-negative, coccoid pathogen isolated from human blood. Whole-genome sequencing of the A. spanius type strain was performed to investigate the mechanism of pathogenesis of this strain at a genomic level. METHODS: The complete genome of A. spanius type strain DSM 23806T was sequenced using single-molecule real-time (SMRT) DNA sequencing. RESULTS: The complete genome of DSM 23806T consists of one circular DNA chromosome of 6425783bp with a G+C content of 64...
June 8, 2018: Journal of Global Antimicrobial Resistance
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