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Journal of Community and Supportive Oncology

Shradha Ahuja, Priyanka Makkar, Sorab Gupta, Ivette Vigoda
Skin may show the first clinical evidence of systemic disease and can be the first clue to malignancy in 1% of cases. Dermatomyositis is an immunologically mediated inflammatory myopathy characterized by proximal muscle weakness, muscle inflammation, and characteristic skin findings. It has an incidence of 1 in 100,000 patients. In 15%-30% cases of dermatomyositis, an underlying malignancy is the cause of paraneoplastic syndrome. Ovarian and breast cancer in women and lung cancer in men are the most common malignancies associated with dermatomyositis...
May 2016: Journal of Community and Supportive Oncology
Felicia Schanche Hodge, Mary Cadogan, Tracy Line Itty, Angela Williams, Arneta Finney
BACKGROUND: Caregivers play a special role in the management and control of cancer-related pain. For American Indians with cancer, caregivers can contribute to patient education, medication compliance, and can facilitate communication between the patient and the provider and the patient and the family. OBJECTIVE: To identify the role(s) of caregivers of American Indian cancer survivors. METHODS: As a part of a large randomized intervention designed to improve barriers to cancer symptom management, 13 focus groups were held among American Indian cancer survivors and their caregivers at Southwest reservations and urban sites...
May 2016: Journal of Community and Supportive Oncology
Matthew H Bertke, Joseph N Shaughnessy, Matthew K Forsthoefel, Liz D Cash, Craig L Silverman, Jeffrey M Bumpous, Kevin L Potts, Rebecca A Redman, Cesar A Perez, Neal E Dunlap
BACKGROUND: There are limited data on the prognostic significance of human papillomavirus (HPV) status in relation to traditional risk factors for head and neck squamous-cell carcinoma (HNSCC) in the postoperative setting. OBJECTIVE: To clarify the impact of HPV status on the risk for HNSCC in the postoperative setting. METHODS: We retrospectively evaluated an institutional cohort of 128 patients with HNSCC patients who had been treated with definitive surgery with or without adjuvant radiotherapy or chemoradiotherapy...
May 2016: Journal of Community and Supportive Oncology
Yoshie Nakayama, Yoshinori Ito, Masahiko Tanabe, Shunji Takahashi
BACKGROUND: Chemotherapy with anthracycline- and cyclophosphamide-containing regimens are classified as highly emetogenic. Combinatory treatments of aprepitant (Apr), palonosetron (Pal), or granisetron (Gra) with dexamethasone are recommended as antiemetic treatments for such emetogenic chemotherapy. We retrospectively examined whether omission of dexamethasone is tolerable for patients with hepatitis B virus (HBV) and diabetes mellitus (DM), for whom it is recommended not receive dexamethasone...
May 2016: Journal of Community and Supportive Oncology
Ciaran M Fairman, Brian C Focht, Alexander R Lucas, Maryam B Lustberg
Previous findings suggest that exercise is a safe and efficacious means of improving physiological and psychosocial outcomes in female breast cancer survivors. To date, most research has focused on post-treatment interventions. However, given that the type and severity of treatment-related adverse effects may be dependent on the type of treatment, and that the effects are substantially more pronounced during treatment, an assessment of the safety and efficacy of exercise during treatment is warranted. In this review, we present and evaluate the results of randomized controlled trials (RCTs) conducted during breast cancer treatment...
May 2016: Journal of Community and Supportive Oncology
Sofia F Garcia, Sheetal M Kircher, Megan Oden, Aubri Veneruso, June M McKoy, Timothy Pearman, Frank J Penedo
Cancer survivorship care plans (SCPs) have been recommended to improve clinical care and patient outcomes. Research is needed to establish their efficacy and identify best practices. Starting in 2015, centers accredited by the American College of Surgeons Commission on Cancer must deliver SCPs to patients completing primary cancer treatment with curative intent. We describe how we established routine SCP delivery at the Robert H Lurie Comprehensive Cancer Center in Chicago, Illinois, using the Quality Implementation Framework...
May 2016: Journal of Community and Supportive Oncology
Marc S Hoffmann, Michael J Overman, Joseph L Nates
Improvements in antiemetic therapy constitute a major advance in oncology. A recent poll of the oncology community by the American Society of Clinical Oncology ranked it as one of the top 5 advances in cancer in the last 50 years. Emetogenicity of chemotherapy is defined by risk of emesis in the patient given no antiemetics; high-risk regimens cause nausea and vomiting in >90% of patients, moderate risk in 30%-90%, and low risk in <30%. This risk profile serves as the basis for empiric antiemetic prophylaxis and offers alternatives to refractory patients...
April 2016: Journal of Community and Supportive Oncology
Daniel Tirotta, Loris Poli, Vittorio Durante
It is widely recognized that eosinophils are found in tumor infiltrates and that their mechanism of action is associated with particular symptoms and prognosis. However, the causes of and reasons for this process remain unclear, as does the exact mechanism by which it occurs. We report on the case of a 71-year-old woman with cholangiocellar carcinoma (CCC) with a marked eosinophilia. When the patient presented at the hospital, she said she was suffering from fatigue, depression, and pain. That triad of symptoms, indicative of peripheral eosinophilia (TABE, or tumor-associated blood eosinophilia) and tissue eosinophilia (TATE, or tumor-associated tissue eosinophilia), are recurrent in oncology...
April 2016: Journal of Community and Supportive Oncology
Sarah Joseph, Hassan Al-Khalisy, Umair Randhawa, John Lazar, Kathryn Peroutka
Hemorrhagic pericardial effusion with associated cardiac tamponade as a de novo sign of malignancy is seen in about 2% of patients.1 Consequently, cardiac tamponade is an oncologic emergency and considered a unique presentation of a malignancy.2 Cancer emergency is defined as an acute condition that is caused directly by the cancer itself or its treatment and requires intervention to avoid death or significant morbidity.3 The mechanism by which cardiac tamponade is classified as a life-threatening emergency stems from its impairment of right ventricular filling, resulting in ventricular diastolic collapse and decreased cardiac output, which can ultimately lead to death...
April 2016: Journal of Community and Supportive Oncology
Lindsey A Mette, Anna Maria Pulido Saldívar, Natalie E Poullard, Ivette C Torres, Sarah G Seth, Brad H Pollock, Gail E Tomlinson
BACKGROUND: Breast and colorectal cancers are common cancers for which genetic risk assessment and counseling are available. However, these services are often limited to metropolitan areas and are not readily accessible to underserved populations. Moreover, ethnic and racial disparities present additional obstacles to identifying and screening high-risk individuals and have a bearing on treatment outcomes. OBJECTIVE: To provide cancer genetic risk assessment and counseling through telemedicine to the remote, underserved primarily Hispanic population of the Texas-Mexico border region...
April 2016: Journal of Community and Supportive Oncology
Camilla Leithold, Karin Jordan, Franziska Jahn, Timo Behlendorf, Judith Schaffrath, Carsten Müller-Tidow, Jörn Rüssel
BACKGROUND: Malnutrition is a common complication in patients suffering from cancer. It is associated with a poor prognosis, reduced quality of life, increased chemotherapy-induced toxicity, and a decreased response to therapy. OBJECTIVE: To evaluate and compare the use of various diagnostic tests for the detection of malnutrition in patients hospitalized for cancer treatment. METHODS: In this single-center, non-interventional reliability study, the nutritional status of 50 patients with cancer was assessed using the Nutritional Risk Screening (NRS-2002), a bioimpedance analysis (BIA), and the measurement of laboratory parameters that reflect the serum visceral protein level...
April 2016: Journal of Community and Supportive Oncology
David Cella, Susan Li, Tracy Li, Thian Kheoh, Mary B Todd, Ethan Basch
BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) is typically associated with declining health-related quality of life (HR-QoL). OBJECTIVE: To assess patient experience with abiraterone acetate (hereafter abiraterone) plus prednisone longitudinally. METHODS: COU-AA-302 was a phase 3, multinational, randomized, double-blind study that enrolled asymptomatic or mildly symptomatic, chemotherapy-naïve patients with mCRPC. Patients were randomized to 1 g abiraterone daily plus 5 mg prednisone BID (n = 546) or placebo plus prednisone (n = 542) in continuous 28-day cycles...
April 2016: Journal of Community and Supportive Oncology
Rudolph M Navari, Cindy K Nagy, Jennifer Le-Rademacher, Charles L Loprinzi
BACKGROUND: Concurrent chemotherapy radiation therapy may result in significant nausea and vomiting. There have been few studies reporting effective interventions for preventing treatment-related nausea and vomiting. OBJECTIVE: To compare olanzapine with fosaprepitant for the prevention of nausea and vomiting in patients receiving concurrent highly emetogenic chemotherapy (HEC) and radiotherapy for locally advanced head and neck or esophageal cancer. METHODS: 120 chemotherapy and radiotherapy naïve patients with head and neck cancer who were receiving concurrent local radiation and cisplatin were randomized to receive either olanzapine or fosaprepitant in combination with palonosetron and dexamethasone for the prevention of chemotherapy- and radiation-induced nausea and vomiting...
April 2016: Journal of Community and Supportive Oncology
Nirav N Shah, Mark Stonecypher, Pallavi Gopal, Selina Luger, Adam Bagg, Alexander Perl
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) that is characterized by a balanced translocation between chromosomes 15 and 17 [t(15;17)], which results in the fusion of the promyelocytic leukemia (PML) and retinoic acid receptor α (RARA) genes. Historically, APL was a fatal disease because of the high relapse rates with cytotoxic chemotherapy alone and a significant bleeding risk secondary to disseminated intravascular coagulation (DIC). However, APL is now one of the most curable hematological malignancies because of molecularly targeted therapies...
March 2016: Journal of Community and Supportive Oncology
Jamie Reynolds, Savitri P Skandan
BACKGROUND: Acrometastasis as initial presentation of metastatic cancer is an extremely rare finding. We describe an unusual case of late-stage non-small-cell lung cancer with metastatic lesions to the great toe and index fnger with associated pain in those areas as the only presenting symptom. CASE PRESENTATION AND SUMMARY: A 71-year-old white woman was referred to the emergency department by her primary care physician for necrosis and swelling of the left great toe for work-up of possible osteomyelitis (Figure 1)...
March 2016: Journal of Community and Supportive Oncology
Samy A Alsirafy, Khalil A Al-Alimi, Salem M Thabet, Afif Al-Nabhi, Nahla A Aklan
BACKGROUND: Adequate symptom assessment is necessary to relieve the high symptom burden experienced by cancer patients. However, health care professionals may depend only on patient's voluntary reporting (VR) to assess symptoms and therefore some symptoms may be missed. OBJECTIVE: To assess the symptom burden experienced by Yemeni cancer patients by using VR and systematic assessment (SA). METHODS: 50 cancer patients were asked an open question to voluntarily report their symptoms...
March 2016: Journal of Community and Supportive Oncology
Paige May, Bradley Figgins
BACKGROUND: Oral anticancer agents are more convenient to use and better tolerated than traditional intravenous therapy but come with significant concerns about patient noncompliance, adverse effects, and high cost. Identifying areas for improvement in the medication use process may help ensure optimal use of these agents. OBJECTIVES: To characterize patient experience with oral anticancer treatment, highlight the areas for improvement in the medication use process, and assess the utility of a pharmacist-led educational program...
March 2016: Journal of Community and Supportive Oncology
Cornelis G Vos, Ramon R Gorter, Koen J Hartemink, J Wolter Oosterhuis
BACKGROUND: Trimodality treatment leads to improved survival for superior sulcus tumor (SST) patients. Not much is known about the impact of this treatment on arm function and patient quality of life. OBJECTIVE: To analyze arm function and quality of life in SST patients undergoing trimodality treatment. METHODS: This was a prospective cohort study of consecutive SST patients treated with trimodality treatment that was conducted between April 1, 2010 and October 31, 2012...
March 2016: Journal of Community and Supportive Oncology
Jeremy M O'Connor, Sheetal M Kircher, Jonas A de Souza
The cost of cancer care is increasing, with important implications for the delivery of high-quality, patent-centered care. In the clinical setting, patents and physicians express a desire to discuss out-of-pocket costs. Nevertheless, both groups feel inadequately prepared to participate in these discussions, and perhaps not surprisingly, the integration of these discussions into clinical practice seems to be the exception rather than the rule. The resulting neglect of financial issues has the potential to cause unnecessary suffering for oncology patents...
March 2016: Journal of Community and Supportive Oncology
Rebecca Dale, Jeremy Edwards, Jane Ballantyne
Pain management with opioids is an integral part of palliative medicine. As the doses and durations of opioid therapy increase, the inherent risks of opioid therapy rise. Although opioids are effective analgesics, they bring with them complex medical and psychological side effects. Aberrant behavior is dangerous and can be difficult to identify as it results in a splitting in the goals of treatment between the patient and providers. One effective strategy in preventing that situation is through the early identification of at-risk patients...
March 2016: Journal of Community and Supportive Oncology
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