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https://www.readbyqxmd.com/read/30541823/correction-suicide-mortality-among-people-accessing-highly-active-antiretroviral-therapy-for-hiv-aids-in-british-columbia-a-retrospective-analysis
#1
(no author information available yet)
No abstract text is available yet for this article.
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30530722/the-canadian-forces-cancer-and-mortality-study-ii-a-longitudinal-record-linkage-study-protocol
#2
Elizabeth Rolland-Harris, Linda VanTil, Mark A Zamorski, David Boulos, Alexander Reicker, Huda Masoud, Richard Trudeau, Murray Weeks, Kristen Simkus
BACKGROUND: Military service exposes personnel to unusual situations with unclear health-related implications, and to identify both immediate and delayed risks, part of health surveillance includes examination of mortality and cancer rates that extends beyond periods of military service. The main aim of the Canadian Forces Cancer and Mortality Study II (CFCAMS II) is to describe the mortality and cancer experience of Canadian Armed Forces personnel (serving and released; about 230 000 people), with the further aim of informing health promotion and prevention programs for serving personnel and services for veterans after they leave the military...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30530721/acceptability-and-tolerability-of-and-adherence-to-hiv-preexposure-prophylaxis-among-toronto-gay-and-bisexual-men-a-pilot-study
#3
Darrell H S Tan, Alexandre Schnubb, James Lawless, Leah Szadkowski, Troy Grennan, James Wilton, Shawn Fowler, Trevor A Hart, John Maxwell, Janet M Raboud
BACKGROUND: Preexposure prophylaxis is efficacious at preventing HIV infection, but concerns persist about adherence and sexually transmitted infections (STIs). We assessed preexposure prophylaxis acceptability, adherence and clinical outcomes in a pilot demonstration project. METHODS: HIV-uninfected adult gay and bisexual men who scored 10 or higher on a validated HIV risk score (HIV Incidence Risk Index for MSM) and reported condomless receptive anal sex were sequentially enrolled into a 1-year open-label single-arm pilot study of daily oral therapy with tenofovir disoproxil fumarate/emtricitabine in Toronto...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30530720/prescribing-and-testing-by-primary-care-providers-to-assess-adherence-to-the-choosing-wisely-canada-recommendations-a-retrospective-cohort-study
#4
Alexander Singer, Leanne Kosowan, Alan Katz, Kheira Jolin-Dahel, Karen Appel, Lisa M Lix
BACKGROUND: Choosing Wisely Canada is an initiative to reduce overprescribing and overtesting. This study assessed adherence to 4 Choosing Wisely Canada recommendations for interventions commonly performed in primary care: (a) antibiotic prescriptions for infections that are probably viral in origin, (b) routine vitamin D tests in low-risk adults, (c) annual screening blood tests and (d) prescriptions of antipsychotic medication to treat symptoms of dementia. METHODS: We conducted a retrospective cohort study of data from the electronic medical records of patients who had an encounter between 2014 and 2016 with a participating Manitoba Primary Care Research Network primary care provider in Manitoba, Canada...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30530719/dose-response-of-sodium-glucose-cotransporter-2-inhibitors-in-relation-to-urinary-tract-infections-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#5
Jennifer R Donnan, Catherine A Grandy, Eugene Chibrikov, Carlo Marra PharmD, Kris Aubrey-Bassler, Karissa Johnston, Michelle Swab, Jenna Hache, Daniel Curnew, Hai Nguyen, John-Michael Gamble
BACKGROUND: The sodium glucose cotransporter-2 (SGLT2) inhibitors are a novel group of drugs for treatment of type 2 diabetes mellitus. We investigated whether there is a dose-response relation between SGLT2 inhibitors and urinary tract infections (UTIs) in patients with type 2 diabetes, relative to other diabetes therapies or placebo. METHODS: We conducted a systematic review and network meta-analysis of randomized controlled trials (RCTs) of SGLT2 inhibitors in patients with type 2 diabetes...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30510042/factors-associated-with-attendance-at-primary-care-appointments-after-discharge-from-hospital-a-retrospective-cohort-study
#6
Kenneth Lam, Howard B Abrams, John Matelski, Karen Okrainec
BACKGROUND: Follow-up with a primary care provider within 1-2 weeks of discharge from hospital has been associated with reduced readmissions. We sought to determine appointment attendance with primary care providers postdischarge and identify factors associated with attendance. METHODS: We conducted a retrospective cohort study involving general medicine patients who had been discharged from hospital between Sept. 1, 2014, and Dec. 30, 2015, from 2 Ontario academic hospitals, and who had been supported by a transitional care specialist and advised to see a primary care provider within 1 week...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30510041/emerging-antimicrobial-resistance-among-escherichia-coli-strains-in-bloodstream-infections-in-toronto-2006-2016-a-retrospective-cohort-study
#7
Sophie Mineau, Robert Kozak, Melissa Kissoon, Aimee Paterson, Anthony Oppedisano, Firas Douri, Kate Gogan, Barbara M Willey, Allison McGeer, Susan M Poutanen
BACKGROUND: Enterobacteriaceae that produce extended-spectrum β-lactamase (ESBL) have emerged as a serious threat, with variable rates depending on geographic region. We determined the prevalence of ESBL-producing Escherichia coli , Klebsiella pneumoniae , K. oxytoca and Proteus mirabilis in bloodstream infections in Toronto from 2006 through 2016. METHODS: All patients with E. coli , K. pneumoniae , K. oxytoca and P. mirabilis isolated from blood in a tertiary care microbiology laboratory in Toronto between 2006 and 2016 (1 isolate per species per patient per year) were included in this retrospective cohort study...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30510040/canadian-regulations-and-legal-ramifications-for-hepatic-encephalopathy-a-descriptive-analysis
#8
Henry H Nguyen, Mark G Swain, Philip Wong, Stephen E Congly
BACKGROUND: Hepatic encephalopathy, a form of brain dysfunction seen in the setting of liver insufficiency, negatively affects driving performance and so is both a patient and public safety issue. We aimed to review the motor vehicle codes in each Canadian province and territory relating to the reporting of patients with hepatic encephalopathy and to search a Canadian legal database for cases of motor vehicle collisions involving patients with hepatic encephalopathy. METHODS: In this descriptive analysis, the transportation agencies of each Canadian province and territory were contacted via telephone and/or email between April and August 2017...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30482758/readmission-following-hypoxic-ischemic-brain-injury-a-population-based-cohort-study
#9
Vincy Chan, David Stock, Binu Jacob, Nora Cullen, Angela Colantonio
BACKGROUND: Readmission to acute care is common and is associated with indicators of suboptimal care and health system inefficiencies. The objective of this study was to identify independent determinants of readmission following survival of hypoxic ischemic brain injury. METHODS: We conducted a population-based retrospective cohort study using Ontario's administrative health data. Survivors of hypoxic ischemic brain injury aged 20 years or more discharged from acute care between fiscal years 2002/03 and 2010/11 were included...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30482757/public-prescription-drug-plan-coverage-for-antiretrovirals-and-the-potential-cost-to-people-living-with-hiv-in-canada-a-descriptive-study
#10
Deborah Yoong, Ahmed M Bayoumi, Linda Robinson, Beth Rachlis, Tony Antoniou
BACKGROUND: Antiretrovirals are expensive and people living with HIV may experience a range of financial burdens when accessing these medications. Our aim was to describe the policy of all Canadian public drug insurance programs for antiretroviral drugs and illustrated how these policies might affect patients' annual out-of-pocket expenditures. METHODS: In December 2017, we reviewed public drug programs offering antiretroviral coverage in Canada using government websites to summarize eligibility criteria...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30459174/correction-screening-for-a-new-primary-cancer-in-patients-with-existing-metastatic-cancer-a-retrospective-cohort-study-correction
#11
(no author information available yet)
No abstract text is available yet for this article.
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30459173/improved-hospital-safety-performance-and-reduced-medicolegal-risk-an-ecological-study-using-2-canadian-databases
#12
Qian Yang, Cathy Zhang, Kristen Hines, Lisa A Calder
BACKGROUND: Few empirical studies have validated the relation between medicolegal risk and hospital patient safety performance. We sought to determine whether there was a relation between in-hospital patient safety events and medicolegal cases involving Canadian physicians. METHODS: In this ecological study, we used Poisson regression to compare data from the Canadian Institute for Health Information's Discharge Abstract Database and the database of the Canadian Medical Protective Association (CMPA) of medicolegal cases over 10 years (2005/06 to 2014/15)...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30459172/patterns-of-borrowing-to-finance-out-of-pocket-prescription-drug-costs-in-canada-a-descriptive-analysis
#13
Ashra Kolhatkar, Lucy Cheng, Steven G Morgan, Laurie J Goldsmith, Irfan A Dhalla, Anne M Holbrook, Michael R Law
BACKGROUND: Out-of-pocket drug costs lead many Canadians to engage in cost-related nonadherence to prescription medications, but our understanding of other consequences such as borrowing money remains incomplete. In this descriptive study, we sought to quantify the frequency of borrowing to pay for prescription drugs in Canada and characteristics of Canadians who borrowed money for this purpose. METHODS: In partnership with Statistics Canada, we designed and administered a cross-sectional rapid-response module in the Canadian Community Health Survey administered by telephone to Canadians aged 12 years or more between January and June 2016...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30404788/screening-for-a-new-primary-cancer-in-patients-with-existing-metastatic-cancer-a-retrospective-cohort-study
#14
Matthew C Cheung, Jill Tinmouth, Peter C Austin, Hadas D Fischer, Kinwah Fung, Simron Singh
BACKGROUND: Cancer screening aims to detect malignant disease early in its natural history when interventions might improve patient outcomes. Such benefits are unclear when screening occurs for patients with an existing high risk of death. Our aim was to study the extent of routine cancer screening for a new primary cancer in patients with existing metastatic cancer. METHODS: We used administrative databases from Ontario to identify a retrospective cohort of adults of eligible screening age (≥ 50 yr) who had a diagnosis of stage IV (metastatic) colorectal, lung, breast or prostate cancer between 2007 and 2012...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30404787/correction-setting-an-implementation-research-agenda-for-canadian-investments-in-global-maternal-newborn-child-and-adolescent-health-a-research-prioritization-exercise
#15
https://www.readbyqxmd.com/read/30389752/prevalence-of-comorbid-chronic-pain-and-mental-health-conditions-in-canadian-armed-forces-active-personnel-analysis-of-a-cross-sectional-survey
#16
Everett Vun, Sarah Turner, Jitender Sareen, Natalie Mota, Tracie O Afifi, Renée El-Gabalawy
BACKGROUND: Chronic pain conditions and mental disorders have high prevalence rates in military populations. However, few investigations have examined the comorbidity between chronic pain conditions and specific mental disorders among Canadian active military personnel. METHODS: We conducted a secondary analysis of data from the 2013 Canadian Forces Mental Health Survey (CFMHS) concerning the population of regular members. Diagnostic interviews assessed the presence of mental disorders, and participants self-reported chronic pain conditions (i...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30389751/assessment-of-scalability-of-evidence-based-innovations-in-community-based-primary-health-care-a-cross-sectional-study
#17
Ali Ben Charif, Kasra Hassani, Sabrina T Wong, Hervé Tchala Vignon Zomahoun, Martin Fortin, Adriana Freitas, Alan Katz, Claire E Kendall, Clare Liddy, Kathryn Nicholson, Bojana Petrovic, Jenny Ploeg, France Légaré
BACKGROUND: In 2013, the Canadian Institutes of Health Research funded 12 community-based primary health care research teams to develop evidence-based innovations. We aimed to explore the scalability of these innovations. METHODS: In this cross-sectional study, we invited the 12 teams to rate their evidence-based innovations for scalability. Based on a systematic review, we developed a self-administered questionnaire with 16 scalability assessment criteria grouped into 5 dimensions (theory, impact, coverage, setting and cost)...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30381324/benefits-challenges-and-ethical-principles-associated-with-implementing-noninvasive-prenatal-testing-a-delphi-study
#18
Charles Dupras, Stanislav Birko, Aliya Affdal, Hazar Haidar, Marie-Eve Lemoine, Vardit Ravitsky
BACKGROUND: Noninvasive prenatal testing is a recent technology that provides some genetic information about the fetus through the analysis of cell-free fetal DNA circulating in maternal blood. We aimed to identify the benefits, challenges and guiding ethical principles most relevant to the clinical integration of noninvasive prenatal testing in Canada, according to experts throughout the country. METHODS: We conducted a 3-round Delphi study involving Canadian experts of contemporary discussions about the ethical and societal implications of prenatal testing and genomic technologies...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30381323/disparities-in-diagnosis-of-advanced-melanoma-a-population-based-cohort-study
#19
Meaghan E Mavor, Harriet Richardson, Qun Miao, Yuka Asai, Timothy P Hanna
BACKGROUND: International studies have observed inequities in stage at diagnosis of melanoma. As this has not been sufficiently studied in Canada, the purpose of this study was to investigate whether there are disparities in the diagnosis of advanced-thickness melanoma in the province of Ontario. METHODS: In this retrospective population-based cohort study, we obtained, abstracted and linked pathology reports for a 65% random sample of all cases of invasive cutaneous melanoma in Ontario from 2007 to 2012 in the Ontario Cancer Registry...
October 2018: CMAJ Open
https://www.readbyqxmd.com/read/30381322/trends-in-treatment-of-problematic-cannabis-use-in-ontario-s-specialized-addiction-treatment-system-from-2010-11-to-2015-16-a-repeated-cross-sectional-study-of-a-health-administrative-database
#20
Sameer Imtiaz, Paul Kurdyak, Andriy V Samokhvalov, Mahhum Mumtaz Mobashir, Bill Que, Daniel Elliot, Jürgen Rehm
BACKGROUND: Little is known about trends in the treatment of problematic cannabis use in Canada. Trends in treatment utilization for problematic cannabis use were examined, as well as trends in the associated sociodemographic characteristics and frequency of cannabis use. METHODS: This was a repeated cross-sectional study using data from the Drug and Alcohol Treatment Information System, capturing utilization of all community funded addiction treatment services in Ontario, Canada...
October 2018: CMAJ Open
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