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International Journal of Mycobacteriology

Priti Kambli, Kanchan Ajbani, Chaitali Nikam, Meeta Sadani, Anjali Shetty, Zarir Udwadia, Sophia B Georghiou, Timothy C Rodwell, Antonino Catanzaro, Camilla Rodrigues
No abstract text is available yet for this article.
September 2016: International Journal of Mycobacteriology
Pugazhenthan Thangaraju, V Durai, M K Showkath Ali
No abstract text is available yet for this article.
September 2016: International Journal of Mycobacteriology
Thanda Tun, Wint Wint Nyunt, Khin Zaw Latt, Ari Samaranayaka, John A Crump, Kyi Kyi Thinn, Gregory M Cook, Htin Lin Aung
No abstract text is available yet for this article.
September 2016: International Journal of Mycobacteriology
Arash Amin-Beidokhty, Zeinab Norouzi, Ali Amiri, Mohammad Almasian, Abbas Azadi, Abdol-Reza Kheirollahi
Pericardial tuberculosis (TB) is rare, but has particularly severe complications and a high mortality rate when not treated. Prompt treatment of pericardial TB is important and can be life-saving. We report a 13-year-old girl with massive pericardial effusion and negative workup for TB, who was empirically treated with an excellent response.
September 2016: International Journal of Mycobacteriology
Bindiya Gupta, Sneha Shree, Shalini Rajaram, Neerja Goel
Genital tract tuberculosis is usually secondary to extragenital tuberculosis. The upper genital tract is usually involved; involvement of cervix and vulva is very uncommon. We present two such rare cases of vulval and cervical tuberculosis diagnosed on histopathology and treated with antitubercular chemotherapy.
September 2016: International Journal of Mycobacteriology
Jessica Mencarini, Sara Veloci, Maria Tullia Simonetti, Antonio Carocci, Massimo Meli, Enrico Tortoli, Gian Maria Rossolini, Alessandro Bartoloni, Filippo Bartalesi
The sternal localization of bone and joint tuberculosis (TB) is rare, has an insidious clinical presentation, and usually affects young adults living in endemic areas. Mycobacterium africanum causes a relevant proportion of human TB in West Africa and in migrants from endemic countries. Here, we report two cases of sternal osteomyelitis due to M. africanum in migrants.
September 2016: International Journal of Mycobacteriology
Diego Heraud, Richard D Carr, Jason McKee, Walter Dehority
Nontuberculous mycobacterial (NTM) adenitis of the head and neck region is well-described in healthy children, most commonly presenting under the age of 5years. Extracervicofacial NTM adenitis is less common. We present a case of NTM inguinal adenitis in a 2-year-old girl, followed by a systematic review of the literature.
September 2016: International Journal of Mycobacteriology
Vydyanath R Narasimha, Kalpana Panati, M Gangadhara Reddy, Venkata Ramireddy Narala
A variant of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is known to be associated with susceptibility to autoimmune diseases and bacterial infections as it acts as an important regulator of T-cell activation. The objective of this study was to evaluate whether PTPN22-C1858T polymorphism is associated with the resistance to pulmonary tuberculosis (PTB). Single-nucleotide polymorphism of PTPN22-C1858T (rs2476601) was genotyped in 124 patients with PTB and 130 healthy controls from India using restriction fragment length polymorphism and direct sequencing of the amplified DNA...
September 2016: International Journal of Mycobacteriology
Mohamed Ali Sbai, Sofien Benzarti, Wafa Gharbi, Wadia Khoffi, Riadh Maalla, Adel Khorbi
Osteoarticular tuberculosis is a rare type of tuberculosis. The spine is the most frequent location, while peripheral locations in the limbs are rare. We report a case of tuberculous osteoarthritis of the metatarsophalangeal joint of the first ray of the foot in a 48-year-old woman. The patient presented with painful swelling of the dorsum of the big toe, insidiously evolving for 6months. Diagnosis was obtained with histological study after surgical biopsy. Antitubercular chemotherapy for 12months promoted healing...
September 2016: International Journal of Mycobacteriology
Dawood Khan, Arpan Choudhary, Avisek Dutta, Imran Khan
Penile tuberculosis (TB) is an uncommon variety of genitourinary TB. It is either primary (via local spread) or secondary (spread of infection from other organs). We encountered a case of rapidly growing penile ulceration, resembling carcinoma. Biopsy revealed the classic picture of TB, which responded well to antitubercular treatment.
September 2016: International Journal of Mycobacteriology
Eman Sobh, Sayed Abd Elsabour Kinawy, Yasser Mohamad Ahmad Abdelkarim, Mahmoud Ahmed Arafa
OBJECTIVE/BACKGROUND: Tuberculosis (TB) is a major health problem. The aim of this study was to examine the pattern of TB in Aswan Chest Hospital, Aswan, Egypt. METHODS: This cross-sectional study was carried out using medical records from the TB registry in Aswan Chest Hospital. The investigated variables included demographic characteristics, type of TB infection, and affected organs. All data were coded and statistically analyzed. RESULTS: The average age of the 557 patients infected with TB was 40...
September 2016: International Journal of Mycobacteriology
Nisha Rathor, Kushal Garima, Naresh Kumar Sharma, Anshika Narang, Mandira Varma-Basil, Mridula Bose
BACKGROUND: The mce4 operon is one of the four mce operons with eight genes (yrbE4A, yrbE4B, mce4A, mce4B, mce4C, mce4D, mce4E and mce4F) of Mycobacterium tuberculosis. It expresses in the later phase of infection and imports cholesterol for long term survival of the bacilli. To cause latent infection, M. tuberculosis undergoes metabolic reprogramming of its genes to survive in the hostile environment like low availability of oxygen and nutrition depletion inside the host. OBJECTIVE: To analyze real time expression profile of mce4 operon under various stress conditions...
September 2016: International Journal of Mycobacteriology
Kebede Tesfay, Shinesh Tesfay, Etsay Nigus, Araya Gebreyesus, Dawit Gebreegziabiher, Kelemework Adane
OBJECTIVE/BACKGROUND: Generating epidemiological data on multidrug-resistant tuberculosis (MDR-TB) is essential to assess the magnitude and trends of anti-TB drug resistance. This study determined the prevalence of MDR-TB among presumptive MDR cases referred to a TB referral laboratory in the Tigray region of Ethiopia. METHODS: A retrospective cross-sectional study was conducted on 262 culture-positive presumptive MDR-TB samples submitted to the Tigray Regional Research Laboratory for MDR testing between January 2013 and August 2014...
September 2016: International Journal of Mycobacteriology
Shalini Rajaram, Priyanka Gupta, Bindiya Gupta, Iqbal R Kaur, Neerja Goel
BACKGROUND: To estimate the prevalence of genital tuberculosis in women with idiopathic chronic pelvic pain on laparoscopy, correlate laparoscopic findings with microbiological and histological diagnosis of tuberculosis and assess the response to anti tubercular treatment (ATT) in these cases. METHOD: In a prospective cohort study, fifty women with idiopathic chronic pelvic pain were enrolled. Diagnostic laparoscopy was done in all women and fluid from pouch of Douglas and/or saline washings were sent for acid fast bacilli (AFB) smear, conventional and rapid culture and DNA polymerase chain reaction (PCR) analysis for diagnosis of genital TB...
September 2016: International Journal of Mycobacteriology
Muayad A Merza, Safer M Haji, Abid Mohialdeen Hasan Alsharafani, Shivan U Muhammed
OBJECTIVE/BACKGROUND: Viral hepatitis, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV), infections and tuberculosis (TB) are a global public health concern. Co-infection with HBV or HCV among TB patients may potentiate the risk of hepatotoxicity induced by anti-TB drugs. Hence, the aim of this study was to identify the prevalence of HBV and HCV among TB patients included in the Duhok National Tuberculosis Program (NTP). METHODS: The Duhok NTP Center is a specialized institution in Duhok City, Iraq, concerned with management and follow-up of TB patients...
September 2016: International Journal of Mycobacteriology
Payam Mehrian, Amin Momeni Moghaddam, Elham Tavakkol, Afshin Amini, Mehrdad Moghimi, Ali Kabir, Aliakbar Velayati
OBJECTIVE/BACKGROUND: Most tuberculosis cases in children are primary infection, with difficult and imprecise diagnosis mainly based on the existence of mediastinal lymphadenopathy. Here, we investigated the characteristics of mediastinal lymphadenopathy in lung computed tomography (CT) scans of children with tuberculosis. METHODS: This cross-sectional study was performed on 75 children with tuberculosis referred to Masih Daneshvari Hospital in Tehran, Iran, from 2009 to 2013...
September 2016: International Journal of Mycobacteriology
Mohammad Arjomandzadegan, Leonid Titov, Parissa Farnia, Parviz Owlia, Reza Ranjbar, Fatemeh Sheikholeslami, Larissa Surkova
OBJECTIVE/BACKGROUND: Detection of mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene could determine resistance to fluoroquinolone antituberculosis drugs. The aim of this study was to detect mutations in QRDRs. METHODS: From 184 clinical isolates of Mycobacterium tuberculosis, ofloxacin resistance was proven in 42 isolates using the proportion method. The molecular basis of resistance to ofloxacin were investigated by the determination of mutations in the QRDR region of the gyrA gene...
September 2016: International Journal of Mycobacteriology
Swapna Kanade, Gita Nataraj, Milind Ubale, Preeti Mehta
OBJECTIVE: To determine the performance of FDA vital staining method in detecting viability of acid fast bacilli in comparison with culture and also its correlation with conventional drug susceptibility testing results for isoniazid and rifampicin. DESIGN: The study was conducted from Jan 2014 to June 2015. Sputum samples of patients taking either Cat I or Cat II anti-TB treatment were tested by Ziehl Neelsen and FDA staining, culture and susceptibility to rifampicin and isoniazid at the end of intensive phase...
September 2016: International Journal of Mycobacteriology
Jyoti Umrao, Dharamveer Singh, Amreen Zia, Swati Saxena, Surendra Sarsaiya, Shushma Singh, Jahanarah Khatoon, Tapan N Dhole
OBJECTIVE/BACKGROUND: Nontuberculous mycobacteria (NTM) infection associated with pulmonary and extrapulmonary disease has been increasing globally. Despite an increase in incidence rate of NTM infection, its prevalence, species diversity, and circulation pattern in India is largely unknown. This study sought to investigate the overall burden and diversity of NTM among both pulmonary and extrapulmonary clinical isolates from a Northern Indian population. METHODS: The study was conducted in the Department of Microbiology, from January 2013 to December 2015...
September 2016: International Journal of Mycobacteriology
Melania Ruggeri, Paola Molicotti, Marina Cubeddu, Sara Cannas, Alessandra Bua, Stefania Zanetti
OBJECTIVE/BACKGROUND: Tuberculosis (TB) has had a recrudescence in the last few decades in Italy as a result of many factors, among which migration from countries where TB is endemic is one of them. In Sardinia, a major island of Italy, there was no knowledge of the mechanisms of transmission of TB in the immigrant subpopulation and the impact it may have on the native subpopulation and on the community as a whole. Therefore, a molecular epidemiological study was carried out to get a clearer picture of the number and genetic features of Mycobacterium tuberculosis strains isolated from immigrants and from natives in Sardinia...
September 2016: International Journal of Mycobacteriology
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