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International Journal of Mycobacteriology

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https://www.readbyqxmd.com/read/29516898/does-a-quality-assurance-training-course-on-chest-radiography-for-radiological-technologists-improve-their-performance-in-laos
#1
LETTER
Akihiro Ohkado, Marvin Mercader, Takuji Date
No abstract text is available yet for this article.
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516897/-mycobacterium-chelonae-osteomyelitis-presenting-as-a-mycobacterial-spindle-cell-pseudotumor
#2
Victoria Thwaites, Julia Colston, Jose Lomas-Cabeza, Zsolt Orosz
We report a case of an 88-year-old man with osteomyelitis of the right ankle, with histopathology demonstrating a Mycobacterium spindle cell pseudotumor. The Mycobacterium contained in this spindle cell pseudotumor was Mycobacterium chelonae. M. chelonae spindle cell pseudotumors are rare and have only been reported twice previously in the literature. Similarly, M. chelonae presenting as the pathogen in bone infection is rare. Due to this unusual presentation of M. chelonae, the antibiotic rationale was based largely on case reports and consisted of imipenem, clarithromycin, and linezolid...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516896/mediastinal-ganglionar-tuberculosis-postcardiac-transplantation
#3
João Bruno Ribeiro Machado Lisboa, Guilherme de Abreu Rodrigues, Diego Corsetti Mondadori, João Paulo Cassiano de Macedo, Orival De Freitas Filho, Paulo Manuel Pêgo-Fernades
The diagnosis and treatment of tuberculosis (TB) in transplanted receivers presents several challenges. TB is an opportunistic infection with high morbidity and mortality in solid organs of transplanted patients, therefore, the diagnosis difficulties. A case of a 30-year-old male, heart transplanted patient, who after being submitted to mediastinoscopy, obtained a result of lymph node TB.
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516895/reactive-perforating-leprosy-erythema-multiforme-like-reactions-sweet-s-syndrome-like-reactions-as-atypical-clinical-manifestations-of-type-2-leprosy-reaction
#4
Hendra Gunawan, Yuri Yogya, Risty Hafinah, Rachel Marsella, Devi Ermawaty, Oki Suwarsa
Type 2 leprosy reactions commonly known as erythema nodosum leprosum, but various clinical manifestations of type 2 leprosy reaction were exist. The highlight of this case series was to report various atypical clinical manifestations of type 2 leprosy reaction such as reactive perforating leprosy, erythema multiforme-like reaction, and sweet's syndrome (SS)-like reaction.
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516894/pneumoperitoneum-during-treatment-of-abdominal-tuberculosis-in-a-non-hiv-patient-natural-progression-or-paradoxical-worsening
#5
Shuwei Zheng, Humaira Shafi
Paradoxical reactions during tuberculosis (TB) treatment are well-described in the HIV seropositive population but less so in the HIV seronegative group. Abdominal TB rarely presents as spontaneous perforation; cases occurring during anti-TB therapy are even rarer. We describe the clinical progress of a case of an HIV-negative patient who developed acute peritonitis while on anti-TB treatment for peritoneal TB through a series of clinical, radiological and histological images. Visceral perforation can occur as a complication of TB treatment...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516893/cutaneous-infection-with-mycobacterium-obuense
#6
Alan S Boyd
This report describes the presence of cutaneous nodules and ulceration of the right leg of 1-year duration in an elderly woman. Prior biopsies had demonstrated dermal and subcutaneous granulomatous inflammation. Special stains for microorganisms and cultures were repeatedly negative. Polymerase chain reaction evaluation of the tissue block demonstrated the presence of Mycobacterium obuense.
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516892/uric-acid-levels-in-patients-on-antituberculosis-drugs-in-the-southwest-region-of-cameroon
#7
Benjamin David Thumamo Pokam, Jude E Enoh, Aniekan-Augusta O Eyo, Nse O Umoh, Prisca W Guemdjom
Background: Antituberculosis drugs (ATDs) efficiently combat Mycobacterium tuberculosis either through direct molecular interactions or those of its metabolites. However, a variety of adverse effects have been reported, leading to frequent interruptions of treatment. To investigate the possible metabolic disturbances resulting from antituberculosis (TB) treatment, the uric acid (UA) level of patients on ATDs was measured in the southwest region of Cameroon. Methods: This hospital-based cross-sectional study involved 96 TB patients on ATDs and 32 controls who were neither on ATDs nor any other treatment that could increase UA levels...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516891/enhancing-antimycobacterial-activity-of-isoniazid-and-rifampicin-incorporated-norbornene-nanoparticles
#8
Kalaiselvi Kumarasingam, Mangayarkarasi Vincent, Shivshankar R Mane, Raja Shunmugam, S Sivakumar, K R Uma Devi
Background: Tuberculosis (TB) has been identified in skeletons over 6000 years old and still remains as the most prevalent infectious disease in the world; thus, there is a need for development of new drugs or tuning of old drugs. Nanotechnology, an advanced technology, plays a vital role in research for the diagnosis and treatment of TB, thus preventing adverse effects and drug resistance. The objective of this study was to enhance the antimycobacterial activity of isoniazid- (INH) and rifampicin (RIF)-incorporated norbornene (NOR) nanoparticles in comparison with plain INH and RIF without nanoparticles...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516890/identification-and-development-of-novel-indazole-derivatives-as-potent-bacterial-peptidoglycan-synthesis-inhibitors
#9
Prasanthi Malapati, Vagolu Siva Krishna, Sriram Dharmarajan
Background: Tuberculosis is well-known airborne disease caused by Mycobacterium tuberculosis. Available treatment regimen was unsuccessful in eradicating the deaths caused by the disease worldwide. Owing to the drawbacks such as prolonged treatment period, side effects, and drug tolerance, there resulted in patient noncompliance. In the current study, we attempted to develop inhibitors against unexplored key target glutamate racemase. Methods: Lead identification was done using thermal shift assay from in-house library; inhibitors were developed by lead derivatization technique and evaluated using various biological assays...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516889/-mycobacterium-abscessus-subsp-abscessus-lung-disease-drug-susceptibility-testing-in-sputum-culture-negative-conversion
#10
Takehiko Kobayashi, Kazunari Tsuyuguchi, Shiomi Yoshida, Yu Kurahara, Naoya Ikegami, Maiko Naito, Shoko Sonobe, Toshiya Maekura, Taisuke Tsuji, Shojiro Minomo, Yoshikazu Inoue, Katsuhiro Suzuki
Background: Among Mycobacterium abscessus complex infections, patients with M. abscessus subsp. abscessus (MAA) lung disease are difficult to treat and no standard therapy has been established. Few reports have investigated the drug susceptibility of these strains. We retrospectively investigated how in vitro drug susceptibility testing (DST) of MAA affects the induction of sputum conversion using pharmacotherapy. Methods: Patients with MAA lung disease diagnosed and treated between 2010 and 2014 at our hospital were enrolled and divided into Group A (sputum conversion without relapse within 1 year) and Group B (persistent positive cultured or negative conversion with relapse)...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516888/identification-of-potential-inhibitors-for-mycobacterial-uridine-diphosphogalactofuranose-galactopyranose-mutase-enzyme-a-novel-drug-target-through-in-silico-approach
#11
Tapaswini Nayak, Lingaraja Jena, Pranita Waghmare, Bhaskar C Harinath
Background: The Mycobacterium tuberculosis (MTB) uridine diphosphogalactofuranose (UDP)-galactopyranose mutase (UGM) is an essential flavoenzyme for mycobacterial viability and an important component of cell wall. It catalyzes the interconversion of UDP-galactopyranose into UDP-galactofuranose, a key building block for cell wall construction, essential for linking the peptidoglycan and mycolic acid cell wall layers in MTB through a 2-keto intermediate. Further, as this enzyme is not present in humans, it is an excellent therapeutic target for MTB...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516887/utilization-of-molecular-and-conventional-methods-for-the-identification-of-nontuberculous-mycobacteria-isolated-from-different-water-sources
#12
Claudia Andrea Tortone, MartIn José Zumárraga, Andrea Karina Gioffr, Delia Susana Oriani
Background: The environment is the nontuberculous mycobacteria (NTM) reservoir, opportunistic pathogens of great diversity and ubiquity, which is observed in the constant description of new species capable of causing infection. Since its introduction, molecular methods are essential for species identification. Most comparative studies between molecular and conventional methods, have used isolated strains from clinical samples. Methods: The aim of this study was to evaluate the usefulness of molecular methods, especially the hsp65-PRA (PCR-Restriction Enzyme Analysis), and biochemical tests in the identification of NTM recovered from water of different origins, using the sequencing of 16S rRNA and hsp 65 genes as assessment methods of the previous ones...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516886/virulence-of-mycobacterium-avium-subsp-hominissuis-human-isolates-in-an-in-vitro-macrophage-infection-model
#13
Laura Rindi, Nicoletta Lari, Carlo Garzelli
Background: Mycobacterium avium subsp. hominissuis (MAH) is an environmental opportunistic pathogen for humans and swine worldwide; in humans, the vast majority of MAH infections is due to strains belonging to specific genotypes, such as the internal transcribed spacer (ITS)-sequevars Mav-A and Mav-B that mostly cause pulmonary infections in elderly patients and severe disseminated infections in acquired immunodeficiency syndrome patients, respectively. To test whether the different types of infections in distinct patients' populations might reflect a different virulence of the infecting genotypes, MAH human isolates, genotyped by ITS sequencing and MIRU-VNTR minisatellite analysis, were studied for the capacity to infect and replicate in human macrophages in vitro...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516885/-in-vitro-activity-of-seven-hospital-biocides-against-mycobacterium-abscessus-implications-for-patients-with-cystic-fibrosis
#14
Steven Caskey, John E Moore, Jacqueline C Rendall
Background: Mycobacterium abscessus pulmonary infection has recently emerged as a significant pathogen in patients with cystic fibrosis (CF) and is associated with significant morbidity and accelerated pulmonary decline. There is a paucity of data describing the activity of hospital biocides against this organism. Methods: M. abscessus isolates (n = 13) were recovered from CF and non-CF respiratory specimens. Seven commonly employed hospital biocides with generic ingredients as follows: acetone, propan-2-ol, diethylene glycol, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, chlorine dioxide, 4% chlorhexidine, alcohol, and disodium carbonate, compound with hydrogen peroxide, 10% sodium hypochlorite were assayed for their biocidal activity against M...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516884/detection-of-multidrug-resistant-tuberculosis-from-stored-dna-samples-a-multicenter-study
#15
Marie Sylvianne Rabodoarivelo, A Brandao, M C Cergole Novella, A G C Bombonatte, B Imperiale, N Rakotosamimanana, N Morcillo, V Rasolofo, J C Palomino, A Martin
Background: In low-income countries, rapid detection of tuberculosis (TB) drug resistance is often restricted by the difficulties of transporting and storing sputum samples from remote health centers to the reference laboratories where molecular tests are available. The aim of this study was to evaluate the performance of four transport and storage systems for molecular detection of rifampicin (RIF) and isoniazid (INH) resistance. Methods: This was a multicenter study...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516883/a-comparison-of-intradermal-test-with-recombinant-tuberculosis-allergen-diaskintest-with-other-immunologic-tests-in-the-diagnosis-of-tuberculosis-infection
#16
Anna Starshinova, Viacheslav Zhuravlev, Irina Dovgaluk, Alexandr Panteleev, Vera Manina, Ulia Zinchenko, Evgenia Istomina, Maria Pavlova, Piotr Yablonskiy
Background: The WHO strategy for eradication of tuberculosis (TB) by 2035 (The End TB Strategy) is aimed at an early and precise diagnosis and subsequent effective treatment of TB patients. Currently, there is no gold standard for the diagnosis of latent TB infection. This study evaluated the diagnostic capabilities of a new intradermal test using recombinant TB allergen (Diaskintest) compared with tuberculin skin test (TST) and commercial TB interferon-gamma release assays (IGRAs). Methods: A post-hoc data analysis that involved examining 860 HIV-negative, bacillus Calmette-Guérin (BCG)-vaccinated persons aged 1-65 years who visited the TB health-care institutions of Saint Petersburg to rule out or confirm an active TB was conducted from 2011 to 2016...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516882/influence-of-interferon-gamma-receptor-1-gene-polymorphisms-on-the-susceptibility-to-pulmonary-tuberculosis-among-sudanese-population
#17
Afra Hasabelrsoul Ali, Alfadhil Alobeid Omer, Nageeb Suleiman Saeed, Elhag E Mansour, Mogahid Mohammed Elhassan
Background: A variety of genetic mutations are thought to be responsible for acquisition of different infections such as tuberculosis (TB). An obvious example for these variations is the link between pulmonary TB and polymorphisms within interferon-gamma receptor 1 (IFN-γ R1) gene. This project is designed to identify the role of IFN-γR1 gene polymorphism in the development of pulmonary TB among Sudanese patients attending several hospitals in Khartoum State. Methods: One hundred (n = 100) patients with active TB and fifty (n = 50) matched healthy controls were investigated for the association of two genetic polymorphisms within IFN-γR1 gene and their risk of developing pulmonary tuberculosis...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516881/estimation-of-pyrazinamidase-activity-using-a-cell-free-in-vitro-synthesis-of-pnca-and-its-association-with-pyrazinamide-susceptibility-in-mycobacterium-tuberculosis
#18
Daniel Rueda, Christine Bernard, Lucas Gandy, Estelle Capton, Rachid Boudjelloul, Florence Brossier, Nicolas Veziris, Mirko Zimic, Wladimir Sougakoff
Background: The main mechanism of resistance to PZA in Mycobacterium tuberculosis relies on mutations on its pyrazinamidase/nicotinamidase. Recently, a rapid colorimetric test relying on the PCR-based in vitro-synthesized-PZase assay has been reported for PZase activity determination from clinical M. tuberculosis isolates but the assay has not been compared with other tests to evaluate PZA susceptibility in M. tuberculosis isolates. Methods: In this study, we have used the PCR-based in vitro-synthesized-PZase assay to analyze the specific pyrazinamidase (PZase) activity of PncA mutants and have correlated the results to the PZA susceptibility phenotype determined by culture in acidic agar medium at pH 6...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516880/proteomic-analysis-of-hydroxyl-radical-induced-resuscitation-of-hypoxia-induced-dormant-mycobacterial-cells
#19
Abhishek Mishra
Background: The genus Mycobacterium has an ability to persist in hostile environments for years before its reactivation in favorable conditions. The major bottleneck in decades of mycobacterial research is a poor understanding of molecular mechanism which assists bacteria to attain dormancy and reactivation later. Methods: In this study, hydroxyl radical was quantified in aerobically growing mycobacterial cells using 2-deoxy-D-ribose assay. Furthermore, extraneous addition of hydroxyl radical in Wayne's dormancy model induced reactivation of dormant cells...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29516879/patients-at-high-risk-of-tuberculosis-recurrence
#20
REVIEW
Mehdi Mirsaeidi, Ruxana T Sadikot
Recurrent tuberculosis (TB) continues to be a significant problem and is an important indicator of the effectiveness of TB control. Recurrence can occur by relapse or exogenous reinfection. Recurrence of TB is still a major problem in high-burden countries, where there is lack of resources and no special attention is being given to this issue. The rate of recurrence is highly variable and has been estimated to range from 4.9% to 47%. This variability is related to differences in regional epidemiology of recurrence and differences in the definitions used by the TB control programs...
January 2018: International Journal of Mycobacteriology
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