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International Journal of Mycobacteriology

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https://www.readbyqxmd.com/read/28559530/performance-of-light-emitting-diode-based-fluorescence-microscopy-to-diagnose-tuberculosis-in-a-rural-hospital-of-ethiopia
#1
LETTER
Ramón Perez-Tanoira, José Manuel Ramos, Laura Prieto-Pérez, Juan Cuadros, Miguel Górgolas
No abstract text is available yet for this article.
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559529/tubercular-infection-of-hydatid-cyst
#2
Tushar Patial, Gopal Singh, Digvijay Thakur, Sahil Chaddha
Tubercular infection of hydatid cyst of the chest wall in an immunocompetent individual is rare. Immune modulation for symbiosis between host cells and the parasite - Echinococcus granulosus favors tubercular infection. In this case report, we describe a case of both these chronic diseases coexisting together, to present as chest wall mass.
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559528/disseminated-mycobacterium-avium-complex-in-an-immunocompetent-host
#3
Joseph M Yabes, Aaron Farmer, Todd Vento
Disseminated Mycobacterium avium complex (DMAC) has historically been described in the immunocompromised. The current epidemiologic research suggests that the incidence of nontuberculous mycobacterial infections is increasing. We present a case of DMAC infection manifesting as hepatic granulomas in a 35-year-old immunocompetent female. This case suggests DMAC infection in a patient without traditional epidemiological risk factors.
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559527/death-caused-by-possible-unrecognized-too-late-recognized-mycobacterium-gordonae-infection-in-a-patient-with-angioimmunoblastic-t-cell-lymphoma
#4
Hrvoje Holik, Ivana Vučinić Ljubičić, Božena Coha
Here, we present possible death caused by Mycobacterium gordonae infection in a patient with angioimmunoblastic T-cell lymphoma. Our patient was severely immunocompromised in whom we suspect to an infection, but we did not have isolates until she died. After she died, we received a positive sputum culture of M. gordonae. We conclude that when having severely immunocompromised patients with suspicion of infection but without isolates we should always consider the saprophytic mycobacteria. These mycobacteria require a long period of isolation, but patients with these mycobacteria are potentially curable if appropriate treatment is applied for a sufficiently long period...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559526/tenosynovitis-an-unusual-presentation-of-leprosy
#5
Sukriti Baveja, Priyanka Borde Bisht, Aradhana Sood
Tenosynovitis is an uncommon presentation of Type 1 reaction in leprosy. Herein, we report a case of bilateral tenosynovitis of wrist joints who after being unsuccessfully treated by a rheumatologist for several months, was finally diagnosed as a case of Hansen's disease (borderline lepromatous) with Type 1 reaction.
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559525/reactivation-pulmonary-tuberculosis-in-two-patients-treated-with-pirfenidone
#6
Mohammad Khan, Majed Alghamdi, Hamdan Al-Jahdali
We report two cases of patients with biopsy-proven idiopathic pulmonary fibrosis (IPF) who were treated with new antifibrotic agent for pirfenidone for more than 12 months. Both cases developed cavitary pulmonary tuberculosis (TB) proven by positive sputum TB culture. Both cases were treated with standard anti-TB drugs for 9 months and had complete clinical and radiological resolution. To our knowledge, these are the first reported human cases of patients with IPF who have been on pirfenidone and developed cavitary pulmonary TB...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559524/isolated-lytic-bone-lesion-in-tuberculosis
#7
Mansoor C Abdulla
Causes of lytic bone lesions include benign, malignant, and infectious processes. Lytic lesions due to tuberculosis (TB) may closely mimic those due to tumors such as bone cyst, osteoblastoma, osteosarcoma, and metastatic bone disease radiologically. Histopathology and culture help in definitive diagnosis and prompt management. We describe an immunocompetent patient with isolated lytic bone lesion in the distal part of ulna due to TB to make the readers aware of such unusual presentations of TB.
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559523/the-first-report-of-two-cases-of-fatal-liver-injury-due-to-anti-tuberculosis-drugs-in-the-presence-of-alpha-1-antitrypsin-deficiency
#8
Shahram Habibzadeh, Jafar Mohammad Shahi, Hassan Ghobadi, Nasrollah Maleki
Tuberculosis (TB) is a major global health problem. Awareness of liver injury due to anti-TB therapy is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation. Here, we report for the first time, two patients of fatal liver injury due to anti-TB drugs in the presence of alpha-1 antitrypsin deficiency. Based on the triad of rapid loss in hepatocyte function, the onset of hepatic encephalopathy, and absence of a prior history of liver disease, the diagnosis of acute liver failure was established...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559522/pulmonary-tuberculosis-a-neglected-risk-factor-for-deep-venous-thrombosis
#9
Abhishek Gupta, Ramakant Dixit
A case of deep venous thrombosis (DVT) of the lower limb in the absence of known common risk factors and its link with underlying pulmonary tuberculosis is described in a young female patient. Possible underlying mechanisms and awareness regarding tuberculosis as a risk factor for DVT is also emphasized.
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559521/contribution-of-putative-efflux-pump-genes-to-isoniazid-resistance-in-clinical-isolates-of-mycobacterium-tuberculosis
#10
Anshika Narang, Astha Giri, Shraddha Gupta, Kushal Garima, Mridula Bose, Mandira Varma-Basil
BACKGROUND: Isoniazid (INH) resistance in Mycobacterium tuberculosis has been mainly attributed to mutations in katG (64%) and inhA (19%). However, 20%-30% resistance to INH cannot be explained by mutations alone. Hence, other mechanisms besides mutations may play a significant role in providing drug resistance. Here, we explored the role of 24 putative efflux pump genes conferring INH-resistance in M. tuberculosis. MATERIALS AND METHODS: Real-time expression profiling of the efflux pump genes was performed in five INH-susceptible and six high-level INH-resistant clinical isolates of M...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559520/modified-rifampin-nanoparticles-increased-solubility-with-slow-release-rate
#11
Poopak Farnia, Ali Akbar Velayati, Saeed Mollaei, Jalaledin Ghanavi
BACKGROUND: Recent advances in nanotechnology-based drug delivery system have been shown to improve either antibacterial efficacy or pharmacokinetics behavior.The aim of this study was to design a rifampin nanoparticle (RIF-NP) which has a high loading capacity with the slow release profile. MATERIAL AND METHODS: The designed chitosan/gelatin/lecithin (Chg/L) RIF-NPs were prepared by multilamellar vesicle. Thereafter, the particle size, zeta potential, morphology, and release rate were investigated...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559519/phenotypic-low-level-isoniazid-resistance-as-a-marker-to-predict-ethionamide-resistance-in-mycobacterium-tuberculosis
#12
Salima Qamar, Joveria Q Farooqi, Kausar Jabeen, Rumina Hasan
BACKGROUND: Tuberculosis is one of the most prevalent diseases in Pakistan. Pakistan has the highest burden of MDR-TB in the Eastern Mediterranean region. Ethionamide is an anti-tuberculous drug frequently used to treat MDR-TB. Its drug susceptibility testing is not easily available in resource limited settings. Since it acts on the same target protein as isoniazid (inhA protein encoded by inhA gene), we sought to find out if phenotypic isoniazid resistance can be a marker of ethionamide resistance...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559518/epidemiology-of-extrapulmonary-and-disseminated-tuberculosis-in-a-tertiary-care-center-in-oman
#13
Zied Gaifer
BACKGROUND: The incidence of extrapulmonary and disseminated tuberculosis (TB) cases is increasing worldwide, and this growth significantly impacts TB-related morbidity and mortality. Little is known about the host risk factors for extrapulmonary and disseminated TB. In this study, we examined those risk factors. MATERIALS AND METHODS: We conducted a retrospective review of all TB cases admitted to Sultan Qaboos University Hospital from 2006 to 2015. We compared extrapulmonary TB (EPTB) cases with pulmonary and disseminated TB cases...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559517/characterization-of-pyrazinamide-resistance-in-consecutive-multidrug-resistant-mycobacterium-tuberculosis-isolates-in-sweden-between-2003-and-2015
#14
Mikael Mansjo, Jim Werngren, Sven Hoffner
BACKGROUND: The first line anti-tuberculosis drug pyrazinamide (PZA) is important when treating PZA susceptible multidrug-resistant tuberculosis (MDR-TB). Several drug resistance surveys have however reported PZA resistance among a significant proportion of multidrug-resistant (MDR) cases and this undoubtedly highlights the need for accurate and reliable detection of PZA resistance. Unfortunately, the testing of PZA susceptibility is associated with technical difficulties and even though the introduction of pncA sequencing has helped to address this issue, misclassification may still occur...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559516/cholecalciferol-for-prophylaxis-against-antituberculosis-therapy-induced-liver-disorders-among-na%C3%A3-ve-patients-with-pulmonary-tuberculosis-a-randomized-comparative-study
#15
Ahmad Farooq Alsayed Hasanain, Ali Abdel-Azeem Hasan Zayed, Reem Ezzat Mahdy, Amany Mohamed Adawi Nafee
BACKGROUND: Patients in countries endemic for chronic viral hepatitis are more vulnerable to antituberculosis therapy-induced liver disorders (ATT-LDs). The aim of this study was to explore the role of cholecalciferol in prophylaxis against ATT-LD among patients with pulmonary tuberculosis (TB) receiving ATT. MATERIAL AND METHODS: We conducted a hospital-based, prospective, randomized, comparative study which included 300 consecutive, naïve patients with pulmonary TB eligible for ATT...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559515/in-silico-structure-based-drug-screening-of-novel-antimycobacterial-pharmacophores-by-dock-gold-tandem-screening
#16
Junichi Taira, Takashi Ito, Hitomi Nakatani, Tomohiro Umei, Hiroki Baba, Shotaro Kawashima, Taira Maruoka, Hideyuki Komatsu, Hiroshi Sakamoto, Shunsuke Aoki
BACKGROUND: Enzymes responsible for cell wall development in Mycobacterium tuberculosis are considered as potential targets of anti-tuberculosis (TB) agents. Mycobacterial cyclopropane mycolic acid synthase 1 (CmaA1) is essential for mycobacterial survival because of its critical role in synthesizing mycolic acids. MATERIALS AND METHODS: We screened compounds that were capable of interacting with the mycobacterial CmaA1 active site using a virtual compound library with an in silico structure-based drug screening (SBDS)...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559514/molecular-typing-of-mycobacterium-abscessus-isolated-from-cystic-fibrosis-patients
#17
Alberto Trovato, Rossella Baldan, Danila Costa, Tullia M Simonetti, Daniela M Cirillo, Enrico Tortoli
BACKGROUND: The possibility of inter-human transmission of Mycobacterium abscessus in cystic fibrosis centres has been recently hypothesized suggesting the need for the molecular characterization of strains isolated from such patients. MATERIALS AND METHODS: One hundred and forty one isolates of M. abscessus grown from sputum samples of 29 patients with cystic fibrosis were genotyped resorting to variable number of tandem repeats (VNTR) determination and whole genome sequencing (WGS)...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559513/extrapulmonary-tuberculosis-in-colombian-children-epidemiological-and-clinical-data-in-a-reference-hospital
#18
Eileen Viviana Fonseca Sepulveda, Luisa Fernanda Imbachí Yunda, Kelly Christina Márquez Herrera, German Camacho Moreno
BACKGROUND: The pediatric population is at increased risk of disseminated and extrapulmonary tuberculosis (TB). There is little information on children affected by this entity. The demographic, clinical, and outcome characteristics of the treatment of children with extrapulmonary TB, treated at a national reference institution between January 1, 2008, and December 31, 2016, are described and analyzed in this work. MATERIALS AND METHODS: This was a retrospective observational study...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559512/atlantoaxial-tuberculosis-outcome-analysis
#19
Srihari Sridharan, Thiruvalluvan Arumugam
BACKGROUND: Tuberculous (TB) spondylitis occurs in <1% of patients with TB. Atlantoaxial involvement is extremely rare amounting to 0.3%-1% cases of TB spondylitis. The management of this entity has been fluctuating with time. Various classifications and management protocols have also evolved. We present our experience in managing this entity in 8 patients. MATERIALS AND METHODS: Retrospective follow-up study of eight patients with atlantoaxial TB over 2 years...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559511/diagnostic-performance-of-genotype-%C3%A2-mtbdrplus-line-probe-assay-in-bronchoalveolar-lavage-for-pulmonary-tuberculosis-diagnosis-in-sputum-scarce-and-smear-negative-patients
#20
Farah Idrees, Muhammad Irfan, Kauser Jabeen, Joveria Farooqi, Rumina Hasan
BACKGROUND: MTBDRplus line probe assay (LiPA) has been endorsed by the World Health Organization for pulmonary tuberculosis (TB) diagnosis. However, its value for Mycobacterium tuberculosis (MTB) detection in bronchoalveolar lavage (BAL) needs exploration. This study determined the diagnostic performance of MTBDRplus in BAL for MTB complex detection and isoniazid/rifampicin resistance in smear-negative and sputum scarce patients. MATERIALS AND METHODS: Retrospective evaluation of data (January-December 2013) from patients who underwent bronchoscopy was done...
April 2017: International Journal of Mycobacteriology
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