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Journal of Research in Pharmacy Practice

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https://www.readbyqxmd.com/read/27843970/ascorbic-acid-in-septic-shock
#1
Hossein Khalili
No abstract text is available yet for this article.
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843969/gemcitabine-and-cisplatin-induced-posterior-reversible-encephalopathy-syndrome-a-case-report-with-review-of-literature
#2
Rohit Santosh Kabre, Krishna Marotirao Kamble
Posterior reversible encephalopathy syndrome (PRES) is a recently described, scarcely documented clinical entity. PRES is caused by various factors, the most common being hypertension, followed by nonhypertensive causes such as renal diseases and immunosuppressive therapy. Recently, some cases have been reported about the association of increased use of cytotoxic and immunosuppressive agents in cancer patients, and relevant reports have increased with advances in radiological examinations. Here, we report a case of gallbladder cancer with liver metastasis undergoing gemcitabine- and cisplatin-based chemotherapy who presented with complaints of seizures, headache, and bilateral lower limb weakness...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843968/moxifloxacin-induced-acute-psychosis-a-case-report-with-literature-review
#3
Faizan Mazhar, Shahzad Akram, Nafis Haider
Third generation quinolones are extensively used to treat a variety of common bacterial infections. Due to their extensive use in clinical practice, an increase in neuropsychiatric events has been reported. We report the case of psychotic symptoms occurs after three doses of moxifloxacin in a healthy adult male with no underlying risk factors. After the discontinuation of moxifloxacin treatment, there was a complete resolution of patient's symptoms. The case draws attention to a rare side effect of a commonly use drug and alert the clinicians to be cautious in those patients that have a baseline risk factors which makes the patient more susceptible to such adverse drug effect...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843967/prevalence-of-pulmonary-edema-among-the-deceased-cases-with-acute-methadone-poisoning-a-report-from-iran
#4
Nastaran Eizadi-Mood, Seyed Amir Hossein Madani Naeini, Mahrang Hedaiaty, Ali Mohammad Sabzghabaee, Maryam Moudi
OBJECTIVE: Methadone poisoning is common in our society, mainly in drug addicts. One of its lethal complications is pulmonary edema. Therefore, we evaluated the prevalence of pulmonary edema in the deceased cases with methadone poisoning and its possible relationship with some medical variables. METHODS: In this cross-sectional study which was done in 2014, we have investigated the deceased patients with methadone toxicity who underwent autopsy at Isfahan Forensic Medicine Department (Iran)...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843966/detecting-and-managing-drug-related-problems-in-the-neurology-ward-of-a-tertiary-care-teaching-hospital-in-iran-a-clinical-pharmacist-s-intervention
#5
Farzaneh Foroughinia, Seyyed Ramtin Tazarehie, Peyman Petramfar
OBJECTIVE: Nowadays, the role of clinical pharmacists has become more prominent by more clinical pharmacists joining the health-care teams. This study was aimed to assess the role of a clinical pharmacist specialist in detecting and managing drug-related problems (DRPs) in the neurology ward of a tertiary care teaching hospital in Iran. METHODS: This is a prospective cross-sectional study conducted on 123 hospitalized patients admitted to the neurology ward of a teaching hospital...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843965/a-new-approach-to-vancomycin-utilization-evaluation-a-cross-sectional-study-in-intensive-care-unit
#6
Atefeh Mahmoodian, Saeed Abbasi, Shadi Farsaei
OBJECTIVE: The risk of methicillin-resistant Staphylococcus aureus infections in Intensive Care Unit (ICU) is increasing in recent years with high rate of morbidity and mortality. Therefore, in this study, we aimed to evaluate the rationale use of vancomycin in ICU patients. METHODS: A total of 200 patients who received at least 48 h intravenous vancomycin were randomly selected from ICU wards, during 9 months. Vancomycin administration and related clinical and laboratory data were gathered from patients' charts and health information system to evaluate the appropriateness of different aspects of vancomycin use during all days which vancomycin were ordered...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843964/exploring-clinical-pharmacists-perception-of-their-impact-on-healthcare-in-khartoum-state-sudan
#7
Anas Mustafa Ahmed Salim, Arwa Hassan Ahmed Elhada, Bashir Elgizoli
OBJECTIVE: The principal aim of this study was to explore the self-perception of clinical pharmacists of their impact on healthcare in Khartoum State, Sudan, how they think doctors perceive their impact, exploring the obstacles that clinical pharmacists are facing, and identifying what clinical pharmacists recommend for a better clinical pharmacy practice in Sudan. METHODS: This was an exploratory cross-sectional study that employed a qualitative method. Individual, in-depth interviews were conducted with a convenient sample of 26 clinical pharmacists working in 14 governmental hospitals in Khartoum State, Sudan, in March 2016...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843963/comparative-evaluation-between-two-methods-of-induced-hypotension-with-infusion-of-remifentanil-and-labetalol-during-sinus-endoscopy
#8
Parvin Sajedi, Ali Rahimian, Gholamreza Khalili
OBJECTIVE: This study aimed to compare two methods of controlled hypotension using labetalol and remifentanil in terms of capability to create controlled hypotension and to investigate the obtained complications, and satisfaction rate of surgeon and patient during functional endoscopic sinus surgery. METHODS: In this prospective clinical trial, 62 patients underwent endoscopic sinus surgery in Al-Zahra and Ayatollah Kashani Hospitals of Isfahan were divided into two groups: in the first group, 20 mg bolus dose of labetalol and then infusion of it, at a rate of 0...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843962/a-comparison-of-five-common-drug-drug-interaction-software-programs-regarding-accuracy-and-comprehensiveness
#9
Raziyeh Kheshti, Mohammadsadegh Aalipour, Soha Namazi
OBJECTIVE: Drug-drug interactions (DDIs) can cause failure in treatment and adverse events. DDIs screening software is an important tool to aid clinicians in the detection and management of DDIs. However, clinicians should be aware of the advantages and limitations of these programs. We compared the ability of five common DDI programs to detect clinically important DDIs. METHODS: Lexi-Interact, Micromedex Drug Interactions, iFacts, Medscape, and Epocrates were evaluated...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843961/does-omega-3-supplementation-decrease-carotid-intima-media-thickening-in-hemodialysis-patients
#10
Mohammad Hossein Kajbaf, Fariborz Khorvash, Mojgan Mortazavi, Shahrzad Shahidi, Firoozeh Moeinzadeh, Ziba Farajzadegan, Shahnaz Amani Tirani
OBJECTIVE: A randomized, double-blind, placebo-controlled clinical trial was performed to assess the effect of omega-3 supplementation (3 g/day) on atherosclerosis progression by measuring carotid intima-media thickness (cIMT) in hemodialysis (HD) patients. METHODS: A total of 54 HD patients were randomized into two groups: Intervention group (n = 27), in which patients were given 3 g/day omega-3 for 6 months and placebo group (n = 27), in which patients received placebo using the same administration protocol...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843960/addition-of-cranberry-to-proton-pump-inhibitor-based-triple-therapy-for-helicobacter-pylori-eradication
#11
Mohammadreza Seyyedmajidi, Anahita Ahmadi, Shahin Hajiebrahimi, Seyedali Seyedmajidi, Majid Rajabikashani, Mona Firoozabadi, Jamshid Vafaeimanesh
OBJECTIVE: Proton pump inhibitor-based triple therapy with two antibiotics for Helicobacter pylori eradication is widely accepted, but this combination fails in a considerable number of cases. Some studies have shown that cranberry inhibits the adhesion of a wide range of microbial pathogens, including H. pylori. The aim of this study was to assess the effect of cranberry on H. pylori eradication with a standard therapy including lansoprazole, clarithromycin, and amoxicillin (LCA) in patients with peptic ulcer disease (PUD)...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843959/antimicrobial-resistance-pattern-of-gram-positive-bacteria-during-three-consecutive-years-at-the-nephrology-ward-of-a-tertiary-referral-hospital-in-shiraz-southwest-iran
#12
Iman Karimzadeh, Mona Mirzaee, Niloofar Sadeghimanesh, Mohammad Mahdi Sagheb
OBJECTIVE: The aim of the present study was to determine the pattern of antimicrobial resistance of Gram-positive bacteria during three consecutive years at the nephrology ward of Namazi Hospital in Shiraz, Southwest of Iran. METHODS: During a 3-year period from 2013 to 2015, data of all biological samples of hospitalized patients at the adult nephrology ward of Namazi Hospital were sent to the central laboratory for identification of Gram-positive microorganisms and subsequently, their antimicrobial susceptibility testing by Kirby-Bauer disc diffusion method were analyzed in a retrospective manner...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843958/evaluation-of-prescriptions-of-medicines-not-included-in-iran-medicine-list-a-cross-sectional-study
#13
Marzieh Zargaran, Shekoufeh Nikfar, Abdol Majid Cheraghali
OBJECTIVE: Iran Food and Drug Administration (IFDA) has the mission to regulate all aspects of pharmaceutical market including registration of the new medicines. Iran Drug Selection Committee has the responsibility to maintain and revise Iran Medicine List (IML). The National law has banned production, importation, distribution, and prescription of medicines not included in IML. Although, IFDA policy makers have created a mechanism to provide medicines not included in the list but might be essential for the treatment of specific patients...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27843957/whether-her2-positive-non-breast-cancers-are-candidates-for-treatment-with-ado-trastuzumab-emtansine
#14
REVIEW
Azadeh Moghaddas, Ali Borhani
The National Comprehensive Cancer Network (NCCN) has recommended Ado-trastuzumab emtansine (T-DM1) as a preferred agent for patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer and prior trastuzumab therapy. Overexpression of HER2 was reported in other cancer types such as bladder, gastric and urogenital carcinosarcomas similar to what is discovered in breast cancer. Some preclinical studies demonstrated the potential anti-tumor effects of T-DM1 in HER2-positive non-breast cancers...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27512717/a-study-of-medication-related-problems-in-stroke-patients-a-need-for-pharmaceutical-care
#15
Viswa Srujani Kanagala, Annapareddy Anusha, Bhukya Srinivasa Rao, Siva Reddy Challa, Krishna Sri Nalla, Raja Sree Gadde
OBJECTIVE: The study was aimed to assess the incidence and characteristics of drug-related problems (DRPs). METHODS: A prospective, observational study was conducted among 133 patients with stroke disease who were aged 18 years or older and admitted to the general medicine ward. During the 6 months study period, the incidence of DRPs was identified using the Pharmaceutical Care Network Europe Foundation classification system, version 6.2. FINDINGS: A total of 133 patients were screened for DRPs...
July 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27512716/attitude-of-nurses-and-pharmacists-on-adverse-drug-reactions-reporting-in-selected-hospitals-in-sokoto-northwest-nigeria
#16
Muhammad Tukur Umar, Shaibu Oricha Bello, Aminu Chika, Oche Mansur Oche
OBJECTIVE: Objective of this study was to assess the attitude of nurses and pharmacists towards adverse drug reactions (ADRs) reporting. METHODS: The questionnaire was designed based on extended "Inman seven deadly sins." Two hundred and seventy-two respondents were selected by stratified sampling technique. The questionnaires were delivered to the respondents at their places of practice. The data generated were analyzed by Sigma XL Software Inc. FINDINGS: There was no statistically significant relationship between demographic profiles and reporting attitude except for qualification...
July 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27512715/dapsone-induced-pure-red-cell-aplasia-and-cholestatic-jaundice-a-new-experience-for-diagnosis-and-management
#17
Kamal Kumar Sawlani, Shyam Chand Chaudhary, Jitendra Singh, Deep Chandh Raja, Sanjay Mishra, Madhu Mati Goel
Dapsone (4,4'- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis...
July 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27512714/ganciclovir-use-evaluation-in-kidney-transplantation-departments
#18
Maryam Mozaffar, Shahrzad Shahidi, Shirinsadat Badri
OBJECTIVE: In this study, we evaluated certain aspects of the usage and administration of one lifesaving, high-cost medication, i.e., Ganciclovir for the prevention and treatment of cytomegalovirus (CMV) infection in transplant patients. METHODS: This study was performed from 2013 to 2015 by conducting a medication use evaluation (MUE) program in the kidney transplantation departments of two tertiary care hospitals in Isfahan, Iran. The MUE criteria for the drug were developed by applying drug information references...
July 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27512713/clinical-outcomes-of-a-diabetes-education-program-for-patients-with-diabetes-mellitus-in-the-micronesian-community-in-hawaii
#19
Mok Thoong Chong
OBJECTIVE: Hawaii has diverse population made up of a cultural mix of different races. Due to different cultural and social influences and language barrier, many of the under-served population who migrated to Hawaii and having diabetes mellitus may be susceptible to long-term complications due to uncontrolled hyperglycemia and medication nonadherence. The purpose of this study was to evaluate the impact of a diabetes education program on the clinical outcomes in patients with diabetes mellitus in the Micronesian community of Hawaii...
July 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27512712/evaluation-of-knowledge-attitude-and-practice-of-community-pharmacists-toward-administration-of-over-the-counter-drugs-for-the-treatment-of-diarrhea-in-children-a-pretest-posttest-survey
#20
Farzaneh Foroughinia, Pedram Zarei
OBJECTIVE: In this study, we aimed to assess knowledge, attitude, and practice of community pharmacists toward administration of over-the-counter (OTC) antidiarrheal drugs in our city pharmacies, Shiraz, Iran. METHODS: In this descriptive cross-sectional study, 90 pharmacies among 128 pharmacies in our city were randomly chosen. The study was designed into two phases: A standard questionnaire to determine the level of knowledge and attitude of pharmacists and a simulated client method to evaluate practice among them...
July 2016: Journal of Research in Pharmacy Practice
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