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Molecular and Clinical Oncology

Yoshimasa Kosaka, Naoko Minatani, Yoko Tanaka, Akiko Shida, Mariko Kikuchi, Hiroshi Nishimiya, Mina Waraya, Hiroshi Katoh, Takeo Sato, Norihiko Sengoku, Hirokazu Tanino, Keishi Yamashita, Masahiko Watanabe
In recent years, treatment options for breast cancer have increased, and prognosis has improved since the 1990s. The present study examined the prognosis for recurrence of breast cancer between 2006 and 2009, in comparison with the results of past treatments, and sought to guide future treatment strategies by elucidating present prognostic factors. A total of 662 patients with breast cancer stage 0-III who underwent surgery at Kitasato University Hospital between January 2006 and March 2009 were included. Cases were classified into four subtypes, based on the presence or absence of hormone receptors and human epidermal growth factor receptor 2 (HER2)...
November 2018: Molecular and Clinical Oncology
Prin Chindaprasirt, Julaluck Promsorn, Piti Ungareewittaya, Nattaphon Twinprai, Jarin Chindaprasirt
Cholangiocarcinoma is an aggressive tumor of the hepatic biliary system and it commonly spreads to the regional lymph nodes, liver and lungs. However, bone metastasis from cholangiocarcinoma is rare compared with other tumors. We herein present the case of a 61-year-old Asian woman who presented with pain in the right scapular area. Magnetic resonance imaging revealed bone destruction and an adjacent soft tissue mass at the right scapula. The findings on computed tomography imaging were compatible with cholangiocarcinoma...
November 2018: Molecular and Clinical Oncology
Maho Ogawa, Tsutomu Namikawa, Toyokazu Oki, Jun Iwabu, Masaya Munekage, Hiromichi Maeda, Takahiko Tamura, Tomoaki Yatabe, Hiroyuki Kitagawa, Ken Dabanaka, Takeki Sugimoto, Michiya Kobayashi, Kazuhiro Hanazaki
The most common sites of breast cancer metastasis are the bone, liver, lung and brain, while gastrointestinal metastasis from breast cancer is rare. We herein present the case of a 68-year-old woman who was admitted to our department with nausea and appetite loss. The patient's medical history included right mastectomy with sentinel lymph node biopsy 5 years earlier for invasive lobular carcinoma, measuring 6.2 cm in greatest diameter, without lymphovascular invasion. Two years after the surgery, the patient developed brain metastasis and underwent metastasectomy to control the neurological symptoms, including unsteadiness and asthenia...
November 2018: Molecular and Clinical Oncology
Blanca Gil-Ibañez, Purificacion Regueiro, Elisa Llurba, Lorena Fariñas-Madrid, Angel Garcia, Berta Diaz-Feijoo
Large-cell neuroendocrine carcinoma (LCNEC) is an uncommon histological subtype of cervical cancer that is associated with poor survival and its occurrence during pregnancy is particularly rare. We herein present the case of a female patient who was diagnosed with cervical LCNEC during pregnancy. The patient declined pregnancy termination and was treated with neoadjuvant chemotherapy with cisplatin and etoposide, without associated toxicity and with good fetal development. At 31.4 weeks of gestation, the fetus was delivered by caesarean section, and the patient underwent radical nerve-sparing hysterectomy with bilateral adnexectomy, along with pelvic and inframesenteric para-aortic lymphadenectomy...
November 2018: Molecular and Clinical Oncology
Fanghua Ye, Wenwen Chai, Minghua Yang, Min Xie, Liangchun Yang
Ataxia-telangiectasia (A-T) is an infrequent autosomal recessive disorder that involves multiple systems and is characterized by progressive cerebellar ataxia, oculocutaneous telangiectasias, radiosensitivity, immune deficiency with recurrent respiratory infections, and a tendency to develop lymphoid malignancies. A-T is caused by mutations in the ATM gene, with >1,000 mutations reported to date and gradually increasing in number. Patients with A-T have an increased incidence of cancers. The aim of the present study was to retrospectively review the case of a patient who presented at the age of 5 years with cerebellar ataxia without telangiectasia, and was diagnosed with Burkitt leukemia by bone marrow biopsy and molecular testing at the age of 7 years at the Xiangya Hospital of Central South University (Changsha, China)...
November 2018: Molecular and Clinical Oncology
Yoshihide Inayama, Kaoru Abiko, Taito Miyamoto, Akihito Horie, Ken Yamaguchi, Tsukasa Baba, Noriomi Matsumura, Sachiko Minamiguchi, Masaki Mandai
Invasive Paget's disease of the vulva (IP) is rare among patients with vulvar cancer. Radiation therapy and chemotherapy are not considered as radical, whereas surgical resection of the tumor with abdominal lymphadenectomy is highly invasive. Thus, more effective and less invasive treatments for IP are required. The present study reports a case of a 64-year-old woman with IP, who was treated with a combination of surgery and concurrent chemoradiotherapy (CCRT). The patient was diagnosed with IP with suspected lymph node metastases to the inguinal and pelvic lymph nodes, after having suffered from pruritus vulvae for 7 years...
November 2018: Molecular and Clinical Oncology
Takashi Takeda, Kouji Banno, Megumi Yanokura, Mayuka Anko, Arata Kobayashi, Asako Sera, Takayuki Takahashi, Masataka Adachi, Yusuke Kobayashi, Shigenori Hayashi, Hiroyuki Nomura, Akira Hirasawa, Eiichiro Tominaga, Daisuke Aoki
Synchronous endometrial and ovarian cancer (SEOC) is a rare entity among gynecological cancers, which exhibits endometrioid histology in its early stages and generally has a good prognosis. However, diagnosis is difficult and recent reports have demonstrated that most clinically diagnosed cases of SEOC have clonally related cancers, indicating metastatic cancer. The association of SEOC with Lynch syndrome is also not clearly understood. We herein present the case of a 41-year-old SEOC patient with MSH2 mutation...
November 2018: Molecular and Clinical Oncology
Atsushi Mitsuhashi, Yusuke Okuma, Yoshitaka Zenke, Yukio Hosomi
Bone metastases (BM) often induce skeletal-related events (SREs) and contribute to poor prognoses in patients with cancer. Osteoclast inhibitors (OIs), such as bisphosphonates (BPs) and denosumab, reportedly prevent SREs and improve quality of life in patients with non-small cell lung cancer and BM, but have not been tested in extensive stage small cell lung cancer (ES-SCLC) patients. From 238 SCLC patient records, the present study reviewed those of 58 BM patients, including 23 who were treated with OIs (OIs group) and 35 who were untreated (untreated group)...
November 2018: Molecular and Clinical Oncology
Dongwei Fan, Chensong Zhang, Xuanhe Li, Changyang Yao, Tingjing Yao
The aim of the present meta-analysis compared left colic artery (LCA) preservation with non-preservation in laparoscopic resection of rectal cancer in terms of feasibility, efficacy and safety. The PubMed, Ovid, Embase, Web of Science, CBM, CNKI, VIP and WanFang Data databases were searched prior to June 2017 for studies comparing LCA preservation and non-preservation in laparoscopic resection for rectal cancer. Two researchers screened the literature independently, extracted the data and evaluated the risk of bias...
November 2018: Molecular and Clinical Oncology
Hiroya Iida, Masaki Kaibori, Hiroshi Wada, Fumitoshi Hirokawa, Takuya Nakai, Masahiko Kinoshita, Michihiro Hayashi, Hidetoshi Eguchi, Shoji Kubo
The aim of the present study was to retrospectively identify prognostic factors for long-term cumulative survival following liver resection in patients with primarily unresectable colorectal cancer who had previously received conversion therapy. A multicentre study was designed to ascertain the appropriate indication for conversion therapy. The study included 34 patients who underwent conversion therapy at 5 university hospitals. Patients' background, operative factors, recurrence rate and survival rate were evaluated, and factors influencing therapy outcomes were identified...
November 2018: Molecular and Clinical Oncology
Takeshi Masuda, Masako Watanabe, Kazunori Fujitaka, Kosuke Hamai, Nobuhisa Ishikawa, Mihoko Doi, Soichi Kitaguchi, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Tadashi Senoo, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori
S-1 is an oral fluoropyrimidine agent used for the treatment of non-small-cell lung cancer (NSCLC). Although S-1 monotherapy has been reported to exhibit lesser hematotoxicity compared with other third-generation chemotherapeutics, digestive toxicity was also frequently observed. Alternate-day administration of S-1 has shown a lower rate of severe digestive toxicity than the daily standard administration in patients with NSCLC. However, the safety of alternate-day S-1 therapy in elderly patients aged 75 years or older has not been investigated...
November 2018: Molecular and Clinical Oncology
Kelsey E Larson, Stephanie A Valente, Chirag Shah, Rahul D Tendulkar, Sheen Cherian, Jame Abraham, Courtney Yanda, Chao Tu, Jessica Echle, Stephen R Grobmyer
Oncotype DX recurrence score (RS) predicts risk of distant disease recurrence, and can guide chemotherapy recommendations in hormone positive, human epidermal growth factor 2-negative, early stage breast cancer. The present study aimed to evaluate the pattern of oncotype testing, RS and adjuvant treatment in patients undergoing intraoperative radiotherapy (IORT). Single center prospective data registry was queried for patients receiving IORT between October 2011 and February 2017. Patient demographics, tumor characteristics, RS, systemic therapy and recurrence information were analyzed...
November 2018: Molecular and Clinical Oncology
Akashi Fujita, Shomei Ryozawa, Masanori Kobayashi, Ryuichiro Araki, Koji Nagata, Kazuhiro Minami, Yuki Tanisaka, Tsutomu Kobatake, Masafumi Mizuide
The differential diagnosis of gastrointestinal subepithelial lesions (SELs) such as gastrointestinal stromal tumors from other benign tumors is important. In the present study, adequate sample rates of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) with a 22G Franseen needle for SELs were evaluated. The present study included 57 consecutive lesions (61 sessions) of EUS-FNA using a 22G needle to evaluate SELs between July 2013 and October 2017. Adequate sample rates were compared retrospectively between a 22G conventional needle group (C group) and a 22G Franseen needle group (F group)...
November 2018: Molecular and Clinical Oncology
Senji Hoshi, Keiji Horio, Kenji Numahata, Kiyotsugu Hoshi, Vladimir Bilim, Isoji Sasagawa
The presence or absence of metastasis has critical implications for therapeutic decision-making in urothelial cancer (UC). Conventional magnetic resonance imaging (MRI) utilizing anatomic T1- and T2-weighted images has modest efficacy in detecting lymph node and distant metastases in UC. However, incorporation of functional techniques including diffusion weighted imaging and dynamic contrast-enhanced imaging, may improve the accuracy of lesion detection and staging. Multiparametric (mp)MRI is widely used in the imaging of prostate and breast cancers, though its usefulness in UC has yet to be fully elucidated...
November 2018: Molecular and Clinical Oncology
Tomoka Usami, Toru Fujioka, Ayaka Yoshida, Hitomi Miyaue, Toshiaki Yasuoka, Yuka Uchikura, Kazuko Takagi, Yuko Matsubara, Takashi Matsumoto, Keiichi Matsubara, Takashi Sugiyama
The introduction of laparoscopic surgery has also been beneficial for patients with gynecological malignancies. In this respect, surgeons should receive related training in the context of human resource development. Hands-on training was introduced using Thiel-embalmed human cadavers (THCs) in 2014. To determine the usefulness of THCs, they were evaluated in terms of tissue color, consistency and operative tactility, among others, compared with in vivo laparoscopic training for gynecological malignancies. Hands-on training sessions using THCs were held for a total of 11 times at Ehime University Graduate School of Medicine between March 2014 and October 2017...
November 2018: Molecular and Clinical Oncology
Yuanyuan Yue, Ya Lu, Xiaojuan Ma, Zhongping Tang, Yinrong Cheng
Proximal-type epithelioid sarcoma (PES) of the vulva is an exceedingly rare malignant soft tissue tumor. We herein present the case of a 41-year-old female patient who presented to our hospital with complaints of a painless mass in the right mons pubis that she had first noticed 3 years prior. Ultrasonographic (US) and color Doppler ultrasonographic (CDUS) examination revealed a solid mass with well-defined, homogeneous hypoechoic structure and quite hypervascular on CDUS. The results of the immunohistochemical examination confirmed the diagnosis of vulvar PES (myxoid variant)...
November 2018: Molecular and Clinical Oncology
Manabu Yamamoto, Keiji Hirata, Masazumi Tuneyoshi, Yoshihiro Yoshida, Hiromitsu Matsuda, Tomonobu Gion, Yohei Tominaga
Mucoepidermoid carcinoma of the anal canal is a rare tumor. We herein report the case of a 74-year-old male patient with a high-grade mucoepidermoid carcinoma of the anal canal who was treated by local surgical resection and subsequent irradiation. However, the patient succumbed to liver and lung metastases 2 years after the procedure. The characteristic findings of mucoepidermoid carcinoma of the anus remain unclear to date due to rarity of this tumor. Since 1954, when this type of tumor was first described, only 58 cases of patients diagnosed with mucoepidermoid carcinoma of the anus have been reported to date...
November 2018: Molecular and Clinical Oncology
Ching-Chun Li, Hsiang-Lin Tsai, Ching-Wen Huang, Yung-Sung Yeh, Tzu-Hsueh Tsai, Jaw-Yuan Wang
Pseudoaneurysms are extremely rare in patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI and bevacizumab in the first-line setting. We herein present two rare cases of iatrogenic pseudoaneurysm developing in patients with mCRC after administration of FOLFIRI and bevacizumab. The first patient was a 57-year-old man who was admitted to our institution with intermittent massive bloody discharge following treatment with the 9th cycle of FOLFIRI combined with bevacizumab. Colonoscopic examination revealed sizeable bloody clots in the rectum, but no active bleeder was identified; however, the patient's hemoglobin level was found to be persistently decreased, so an angiography was performed...
November 2018: Molecular and Clinical Oncology
Takahiro Koyanagi, Yoko To, Miho Ando, Sakiko Matsuoka, Sumie Nakamura, Maki Goto, Haruhiko Kondo, Fuyuki Eguchi, Hiroshi Tsujioka
Primary peritoneal carcinosarcoma is extremely rare and only few cases have been reported in the literature to date. We herein present a case of carcinosarcoma of the Douglas pouch in a 73-year-old Japanese woman. The patient complained of fever and lower abdominal pain, and a large pelvic mass (>10 cm in diameter) was detected, with rectal invasion. Laparotomy was performed and revealed a left ovarian abscess and a Douglas pouch mass; however, there was no obvious tumor involvement of the bilateral ovaries or uterus...
November 2018: Molecular and Clinical Oncology
Tomohiko Murakami, Satoshi Otsubo, Ryo Namitome, Masaki Shiota, Junichi Inokuchi, Ario Takeuchi, Eiji Kashiwagi, Katsunori Tatsugami, Masatoshi Eto
The present study investigated clinical factors affecting perioperative outcomes in robot-assisted radical prostatectomy (RARP). The study included 625 Japanese cases treated with RARP between 2009 and 2017. The association between clinical factors (age, overweight status, prostate volume, clinical T-stage, nerve sparing, lympho-node dissection, and the number of experienced cases) and perioperative outcomes (operation time, estimated blood loss, catheterization duration, and perioperative complication) were analyzed...
November 2018: Molecular and Clinical Oncology
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