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Molecular and Clinical Oncology

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https://www.readbyqxmd.com/read/28123746/high-expression-of-adamts5-is-a-potent-marker-for-lymphatic-invasion-and-lymph-node-metastasis-in-colorectal-cancer
#1
Naotsugu Haraguchi, Nobuyoshi Ohara, Jun Koseki, Hidekazu Takahashi, Junichi Nishimura, Taishi Hata, Tsunekazu Mizushima, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori
Members of the ADAMTS family contain propeptide, metalloproteinase and disintegrin domains and serve key roles for cancer cell proliferation, progression and metastasis. Although overexpression of ADAMTS5 has been reported in glioblastoma, and head and neck cancer, little has been demonstrated in colorectal cancer types. The present study aimed to clarify the significance of ADAMTS5 for clinicopathological factors and prognosis in colorectal cancer. The mRNA expression of ADAMTS5 was measured in 143 colorectal cancer specimens...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123745/association-of-tumor-necrosis-factor-%C3%AE-polymorphism-with-chemotherapy-induced-oral-mucositis-in-patients-with-esophageal-cancer
#2
Kazuhiko Sakamoto, Shigeru Takeda, Shinsuke Kanekiyo, Mitsuo Nishiyama, Masahiro Kitahara, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Shoichi Hazama, Naoko Okayama, Hiroaki Nagano
The purpose of this study was to evaluate the association between tumor necrosis factor (TNF)-α polymorphisms and oral mucositis (OM) from 5-fluorouracil (5-FU) plus cisplatin (CDDP) chemotherapy for esophageal cancer. The rs1799964 polymorphism of TNF-α was genotyped using the tetra-primer amplification refractory mutation system polymerase chain reaction. The experimental group comprised 64 patients who received chemotherapy for esophageal cancer between 1997 and 2004; a total of 106 patients between 2005 and 2013 were investigated as the validation group...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123744/complete-response-to-azacitidine-priming-and-nab-paclitaxel-in-non-hodgkin-lymphoma-resistant-to-biochemotherapy
#3
Randy C Bowen, Andrew W Hahn, Thomas W Butler, Hung T Khong
The standard of care for first-line therapy in diffuse large B-cell lymphoma (DLBCL) is the rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) regimen. For patients who fail to respond, have an incomplete response or relapse, numerous effective options exists besides salvage cisplatin-based regimen and autologous stem cell therapy. Even with this approach, the outcome remains very poor for this group of patients. The present case illustrates a 55-year-old woman diagnosed with DLBCL, who experienced an early incomplete response, later progression during treatment with the R-CHOP regimen...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123743/brenner-tumor-of-the-testis-a-case-report-and-review-of-the-literature
#4
Jing Quan, Lu Jin, Jia Hu, Tao He, Xiang Pan, Yu Ding, Jian Peng, Zhebo Chen, Shangqi Yang, Xiangming Mao, Yongqing Lai
Brenner tumor is a rare type tumor, which mainly develops in the ovaries and rarely in the adnexal region and urinary system. To the best of our knowledge, only 5 cases of testicular Brenner tumor have been reported to date. In this report, we present the case of a 55-year-old patient who noted a swelling of the right scrotum for ~20 days. The clinical suspicion was an epididymal cyst. However, following surgical resection and subsequent pathological examination, the mass was diagnosed as a testicular Brenner tumor...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123742/diffuse-large-b-cell-non-hodgkin-lymphoma-involving-the-unilateral-carotid-space-in-an-elderly-man-a-case-report
#5
Bo Chen, Chunying Zou, Jianqing Wu
An 84-year-old man presented with a history of repeated syncope and decreased heart rate and blood pressure over the last month. On physical examination, a mass sized ~3×3 cm was palpable in the left submandibular area; the mass was hard, poorly mobile, without tenderness or local skin irritation. The computed tomography angiography examination revealed a soft tissue mass in the neck, at the level of the left carotid bifurcation and above. The left common carotid artery bifurcation and internal and external carotid artery segment were embedded in the mass, and there were multiple enlarged lymph nodes in the left neck...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123741/hepatocellular-carcinoma-with-inferior-vena-caval-and-right-atrial-tumor-thrombi-and-massive-pulmonary-artery-embolism-a-case-report
#6
Jian Huang, Ze-Ya Pan, Li Li, Bei-Ge Jiang, Fang-Ming Gu, Zhen-Guang Wang, Zhi-Hong Wang, Wei-Ping Zhou
The aim of the present study was to report the case of a 55-year-old female patient with a sizeable (7.1×6.2 cm) hepatocellular carcinoma (HCC), who succumbed to massive pulmonary artery embolism. The main symptoms included sudden thoracodynia, dyspnea and transient coma. The initial diagnosis was HCC according to the typical abdominal ultrasound and triple-phase abdominal computed tomography (CT) findings, chronic hepatitis B infection and elevated α-fetoprotein levels (1,036 µg/l; normal, 0-20 µg/l). Two days following admission, the patient developed recurrent chest pain and shortness of breath...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123740/efficacy-of-bevacizumab-therapy-for-unresectable-malignant-glioma-a-retrospective-analysis
#7
Hajime Yonezawa, Hirofumi Hirano, Hiroyuki Uchida, Mika Habu, Ryosuke Hanaya, Tatsuki Oyoshi, Yuko Sadamura, Tomoko Hanada, Hiroshi Tokimura, Fm Moinuddin, Kazunori Arita
Bevacizumab (BEV), an inhibitor of vascular endothelial growth factor A, has been used for primary and recurrent malignant gliomas in Japan since June, 2013. Previous randomized controlled studies demonstrated that BEV prolonged the progression-free survival, but not the overall survival (OS) of patients with newly diagnosed glioblastoma. The aim of the present study was to elucidate the effect of BEV on the OS of patients with unresectable malignant gliomas. Of the 440 cases of malignant glioma initially treated in our institute between 2000 and 2015, 88 were not suitable for maximal resection due to patient age, physical condition, tumor location and extent, or the patient's wishes...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123739/urachal-carcinoma-report-of-two-cases-and-review-of-the-literature
#8
Jing Quan, Xiang Pan, Lu Jin, Tao He, Jia Hu, Bentao Shi, Jian Peng, Zhebo Chen, Shangqi Yang, Xiangming Mao, Yongqing Lai
Urachal carcinoma is a rare tumor that most commonly occurs in ovaries and less often in the adnexal region and urinary system. We herein present two cases of urachal carcinoma: One case was a 32-year-old male patient who presented with painless hematuria with blood clots for 1 month, whereas the other case was a 50-year-old woman who presented with gross hematuria with mild dysuria, urgency and frequent urination for 1 year. Following surgical resection, the two patients were diagnosed with urachal adenocarcinoma (mixed type) and urachal mucinous adenocarcinoma, respectively, based on the histopathological examination...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123738/correlation-of-nedd4-1-and-pten-expression-with-the-invasive-capacity-of-pituitary-adenomas
#9
Jing Zhang, Xin Li, Yanyan Zhang
The aim of the present study was to correlate the expression of neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with the invasive capacity of pituitary adenomas. A total of 50 pituitary adenoma tissues and 10 normal pituitary tissues were divided into the invasive group (26 cases), the non-invasive group (24 cases) and the normal group (10 cases). The expression of NEDD4-1 and PTEN was determined by immunohistochemistry...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123737/cardiac-metastasis-of-squamous-cell-carcinoma-of-the-thyroid-gland-with-severe-disseminated-intravascular-coagulation-a-case-report
#10
Tomoyasu Yoshihiro, Kenji Tsuchihashi, Hitoshi Kusaba, Torahiko Nakashima, Teppei Obara, Kenta Nio, Kotoe Takayoshi, Hiroyuki Kodama, Nobuhiro Tsuruta, Hideyuki Kiyohara, Kaori Asai, Eiji Harada, Kenjiro Kamezaki, Takeshi Arita, Masanobu Sato, Hidetaka Yamamoto, Shuji Arita, Hiroshi Ariyama, Keita Odashiro, Yoshinao Oda, Koichi Akashi, Eishi Baba
Distant metastasis of primary squamous cell carcinoma (SCC) of the thyroid gland is rare and, to the best of our knowledge, cardiac metastasis has not been reported to date. A 57-year-old man underwent surgery and adjuvant chemoradiotherapy for stage IVA SCC of the thyroid gland. After 3 months, the patient was admitted to the Kyushu University Hospital (Fukuoka, Japan) with subcutaneous hematomas of the left thigh and lower leg, and he was diagnosed with cardiac and mediastinal lymph node metastases of SCC of the thyroid gland with severe disseminated intravascular coagulation (DIC)...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123736/rare-virilizing-granulosa-cell-tumor-in-an-adolescent
#11
Dorottya Bús, Mária Buzogány, Gyöngyi Nagy, György Vajda
Hormone-producing malignancies are rare in children or adolescent patients: Only 0.1% of all ovarian tumors and 4-5% of granulosa cell tumors occur in the sexually non-active ages. Granulosa cell tumors (GCTs) are sex cord-stromal tumors of the ovary, representing 7-8% of all ovarian neoplasms. A total of 95% of all GCTs are adult-type, and only 5% are diagnosed as juvenile-type GCT. A majority of children with juvenile-type GCT present with isosexual precocious pseudopuberty due to excessive estrogen production, although virilizing, testosterone-producing, juvenile-type GCTs are rare, occurring only in 2-3% of cases...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123735/lipomatous-angiomyofibroblastoma-of-the-vulva-a-case-report-and-review-of-the-literature
#12
Susumu Matsukuma, Ayano Koga, Ryohei Suematsu, Hiroaki Takeo, Kimiya Sato
Lipomatous angiomyofibroblastoma is extremely rare, with only 16 cases reported to date. We herein describe an additional case arising in the left vulvar region of a 49-year-old woman. The resected 5.3-cm yellowish tumor predominantly consisted of fat cells (85% of the tumor), together with medium- and small-sized vessels, multifocal fibrotic areas and pseudoangiomatous spaces. Spindle, rounded, and/or epithelioid tumor cells proliferated in a nest and/or cord-like pattern, or singly within perivascular fibrous tissues and between fat cells...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123734/diagnostic-and-therapeutic-challenges-in-extragonadal-yolk-sac-tumor-with-hepatoid-differentiation-a-case-report
#13
Vanja Zeremski, Christian Mawrin, Thomas Fischer, Enrico Schalk
Yolk sac tumors (YSTs) are rare aggressive tumors, arising most commonly in the gonads and occurring mainly in young adults. We herein report a case of an extragonadal YST with hepatoid differentiation localized in the brain and lung. A 41-year old man presented to our hospital with a generalized seizure. A head computed tomography and magnetic resonance imaging examination revealed a large mass in the left occipital lobe with associated edema. Following complete resection, the histopathological examination revealed that the mass was a highly malignant epithelial tumor with a hepatoid pattern...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123733/increased-serum-leptin-level-in-overweight-patients-with-colon-carcinoma-a-cross-sectional-and-prospective-study
#14
Di Wang, Lichen Gao, Kuiyu Gong, Qin Chai, Guihua Wang
Leptin is associated with carcinogenesis and progression of various cancers. However, the changes of the serum leptin level in Chinese overweight patients with colon carcinoma and its association with response to treatment in these patients have rarely been investigated. A total of 63 Chinese overweight patients with colon cancer and 40 body mass index-matched control subjects were recruited in the present study. The serum leptin levels of colon cancer patients prior to and 21 days after colectomy, as well as those of healthy controls, were measured and compared...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123732/a-giant-and-insidious-subphrenic-biloma-formation-due-to-gallbladder-perforation-mimicking-biliary-cystic-tumor-a-case-report
#15
Guwei Ji, Feipeng Zhu, Ke Wang, Chenyu Jiao, Zicheng Shao, Xiangcheng Li
Gallbladder perforation (GBP) represents a rare, but potentially life-threatening, complication of acute cholecystitis. GBP is subdivided into three categories whereas the development of biloma is extremely rare. The present case study reports on a 40-year-old man with a 10-year history of calculus cholecystitis, who was referred to The First Affiliated Hospital of Nanjing Medical University (Nanjing, China) for the surgical treatment of an emerging massive hepatic entity with insidious symptoms and normal laboratory tests...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123731/bone-langerhans-cell-histiocytosis-with-pulmonary-involvement-in-an-adult-non-smoker-a-case-report-and-brief-review-of-the-literature
#16
Jie Shen, Shicheng Feng
Langerhans cell histiocytosis (LCH) is a rare disease of unknown cause, which encompasses a set of disorders of multiple organs with various clinical presentations that share the common characteristic of sizeable Langerhans cell infiltration. The clinical spectrum of LCH ranges from solitary bone lesions to involvement of other organs. lung involvement in LCH may be part of a multisystem disease, which almost exclusively occurs in adult smokers, while it is overlooked or misdiagnosed in the majority of non-smokers...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123730/pseudocirrhosis-caused-by-regorafenib-in-an-advanced-rectal-cancer-patient-with-multiple-liver-metastases
#17
Kensuke Kumamoto, Shungo Endo, Noriyuki Isohata, Azuma Nirei, Daiki Nemoto, Kenichi Utano, Takuro Saito, Kazutomo Togashi
A 70-year-old man who was diagnosed with unresectable advanced rectal cancer with multiple liver metastases, received oxaliplatin-based treatment with bevacizumab as first-line chemotherapy and irinotecan-based treatment with bevacizumab as second-line chemotherapy for a total of 17 months. The patient was treated with regorafenib (160 mg/day for 3 weeks) as third-line chemotherapy. Following completion of one course of regorafenib treatment, the patient complained of abdominal distension. Computed tomography (CT) examination identified liver atrophy and massive ascites, while no such symptoms were observed prior to the regorafenib treatment...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123729/randomized-phase-ii-study-of-sequential-carboplatin-plus-paclitaxel-and-gefitinib-in-chemotherapy-na%C3%A3-ve-patients-with-advanced-or-metastatic-non-small-cell-lung-cancer-long-term-follow-up-results
#18
Emi Kubo, Noboru Yamamoto, Hiroshi Nokihara, Yutaka Fujiwara, Hidehito Horinouchi, Shintaro Kanda, Yasushi Goto, Yuichiro Ohe
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib was initially approved in Japan in 2002 for the treatment of advanced or metastatic non-small-cell lung cancer (NSCLC); however, the optimal order of conventional cytotoxic chemotherapy (carboplatin and paclitaxel) and gefitinib administration has not been determined. We conducted a randomized phase II study of carboplatin and paclitaxel followed by gefitinib vs. gefitinib followed by carboplatin and paclitaxel to select a candidate for further development in a phase III study of chemotherapy-naïve patients with advanced or metastatic NSCLC, regardless of their EGFR mutation status...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123728/clinicopathological-features-for-predicting-central-and-lateral-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-analysis-of-66-cases-that-underwent-central-and-lateral-lymph-node-dissection
#19
Yang Tao, Chongjie Wang, Liye Li, Haijun Xing, Yun Bai, Bing Han, Zhiyan Liu, Xiangshan Yang, Shourong Zhu
Currently the surgical approach for papillary thyroid microcarcinoma (PTMC), particularly the range of lymph node dissection, remains controversial. The present study aims to evaluate the risk factors for central and lateral lymph node metastasis (CLNM and LLNM) for appropriate clinical decision of neck lymph node dissection in PTMC. A total of 66 cases of PTMC that underwent unilateral or bilateral lobectomy plus prophylactic cervical lymph node dissection were collected for clinicopathological evaluation, including age, gender, tumor size, subtypes, extrathyroidal invasion, multifocality, calcifications, loss of cellular polarity/cohesiveness (LOP/C) in the invasive front, CLNM and LLNM, and retrospectively analysis...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28123727/systemic-chemotherapy-with-folfox-in-metastatic-grade-1-2-neuroendocrine-cancer
#20
Marjorie Faure, Patricia Niccoli, Aurelie Autret, Gerard Cavaglione, Laurent Mineur, Jean-Luc Raoul
Neuroendocrine tumors (NETs) comprise a heterogeneous group of malignancies with various clinical presentations and evolution. NETs are often diagnosed at a late stage, when they are already metastatic. Treatment is currently based on traditional chemotherapies, such as streptozocin, with serious side effects. The favorable toxicity profile of the combination of 5-fluorouracil with oxaliplatin, together with its significant antitumor activity in several gastrointestinal malignancies, led to the evaluation of its efficacy and tolerability in patients with advanced grade 1/2 (G1/G2) NETs...
January 2017: Molecular and Clinical Oncology
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