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Molecular and Clinical Oncology

Thorsten Schmidt, Ivonne Rudolph, Tobias Wozniak, Dana Ruetters, Marion T Van Mackelenbergh, Jutta Huebner
The present study aimed to evaluate the feasibility of ballroom dancing for patients with cancer and their partners, and develop a simple method for assessing its effects on the patients' well-being. A total of 11 pairs (14 patients and 8 healthy partners) participated. Participation was open, and there were no restrictions in terms of the type of cancer, treatment or comorbidities. An anonymous standardized questionnaire allowing participants to rate their well-being on a visual analogue scale (VAS) from 1 to 10 was used...
September 2018: Molecular and Clinical Oncology
Kenji Yoshikawa, Takeshi Fukuda, Ryo Uemura, Hiroaki Matsubara, Takuma Wada, Masaru Kawanishi, Reiko Tasaka, Mari Kasai, Yasunori Hashiguchi, Tomoyuki Ichimura, Tomoyo Yasui, Toshiyuki Sumi
Approximately 40% of all patients with ovarian cancer in Japan are aged ≥65 years. The aim of the present study was to evaluate the differences in prognosis and prognostic factors between elderly and younger patients with epithelial ovarian cancer. A total of 114 patients with International Federation of Gynecology and Obstetrics (FIGO) stage I-IV ovarian cancer who were initiated on primary treatment at the Osaka City University Hospital (Osaka, Japan) were included in this study. Patient characteristics, treatment outcome and prognosis were compared between elderly (aged ≥65 years) and younger patients, and the prognostic factors associated with overall survival were evaluated by univariate and multivariate analyses...
September 2018: Molecular and Clinical Oncology
Xiqi Peng, Zuwei Li, Liang Zhou, Liwen Zhao, Xionghui Wu, Yu Yang, Shangqi Yang, Yun Chen, Yongqing Lai
Schwannomas, arising from Schwann cells of peripheral nerve sheaths, are primarily benign tumors. They are rarely found in the retroperitoneal space. To date, ~30 cases on giant retroperitoneal schwannomas have been reported. Those with a location of pararenal space are even rarer. Clinically, they are often misdiagnosed as malignancies. In the present study, a case of a 35-year-old woman with a giant schwannoma measuring 13 × 8.5 × 6.5 cm in the posterior pararenal space of left retroperitoneum was presented, which was thought to be a malignant tumor from the result of computed tomography scan...
September 2018: Molecular and Clinical Oncology
Junjun Li, Xiaomei Liu, Caijun Yuan
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are effective in the treatment of advanced non-small-cell lung cancer (NSCLC) with leptomeningeal metastases (LM); however, a proportion of the patients with resistant tumors do not benefit from EGFR-TKI treatment. In the present study the case of a female patient with advanced lung adenocarcinoma harboring the EGFR L858R mutation (encoded in exon 21) who developed intracranial metastases following treatment with erlotinib after gefitinib failure is reported...
September 2018: Molecular and Clinical Oncology
Kazuhiko Hashimoto, Shunji Nishimura, Naohiro Oka, Hiroki Tanaka, Ryosuke Kakinoki, Masao Akagi
Superficial acral fibromyxoma is a very rare soft tissue tumor. Fetsch et al first described the condition in 2001. It often occurs in the fingers and toes and has slow-progressive features. Since being described, a few cases occurring in the great toe have been reported. The present study indicated a case of a 37-year-old male kickboxer with a history of a rapid-growing lump under the nail of his left great toe with bone erosion. The patient was suspected to have a soft tissue tumor under the nail, such as a glomus tumor, as a differential diagnosis...
September 2018: Molecular and Clinical Oncology
Shinji Ohtake, Takashi Kawahara, Yukari Ishiguro, Teppei Takeshima, Shinnosuke Kuroda, Koji Izumi, Hiroshi Miyamoto, Hiroji Uemura
Oxidative stress is a primary cause of vascular endothelial damage. In the prostate, ischemia increases the levels of reactive oxygen species, growth factors and cytokines, and induces the development of angiogenesis, which results in cancer progression. The expression levels of an oxidative stress marker, 8-hydroxyguanosine (8-OHdG), were compared between prostate cancer and non-neoplastic prostate tissues. A prostate tissue microarray composed of 10 cases of prostatic adenocarcinoma and 70 cases of benign prostatic hyperplasia was immunohistochemically stained for 8-OHdG...
September 2018: Molecular and Clinical Oncology
Jieyun Xia, Haiying Sun, Zhiling Yan, Feng Zhu, Kai Zhao, Kailin Xu
Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) complicated by bone marrow necrosis (BMN) and acute renal insufficiency (ARI) is rare in clinical practice. The aim of the present study was to summarize the clinical characteristics and treatment methods of a case of Ph+ ALL complicated by BMN and ARI. A 23-year-old male patient presented with pyrexia and a 2-month history of bone pain, and was diagnosed with Ph+ ALL complicated with BMN and ARI on peripheral blood tests, blood biochemistry tests, BM smear and fluorescence in situ hybridization...
September 2018: Molecular and Clinical Oncology
Takashi Tamura, Kayo Suzuki, Taketoshi Yasuda, Shigeharu Nogami, Kenta Watanabe, Masahiko Kanamori, Tomoatsu Kimura
Extraskeletal osteosarcoma (ESOS) is a rare soft tissue sarcoma accounting for 1-2% of all soft tissue sarcomas. ESOS originating in the superficial (cutaneous-subcutaneous) tissue is extremely rare, and only 17 cases with subcutaneous ESOS have been reported in detail to date. The aim of the present study was to report an additional case of subcutaneous ESOS of the lower leg and review previous reports of subcutaneous ESOS, focusing on the clinical characteristics, including the MIB-1 labeling index, treatment methods and outcomes...
September 2018: Molecular and Clinical Oncology
Yulin Lai, Liang Zhou, Jia Hu, Wenhua Li, Lin Cui, Yongqing Lai, Liangchao Ni
[This corrects the article DOI: 10.3892/mco.2018.1610.].
August 2018: Molecular and Clinical Oncology
Seza Tetikkurt, Elif Çelik, Hazal Taş, Tuğçe Cay, Selman Işik, Abdullah Taner Usta
The present study was conducted to identify endometrial and myometrial lesions coexisting with adenomyosis, and to evaluate the clinicopathological characteristics of endometrial adenocarcinomas associated with adenomyosis. A retrospective analysis of the resected uterine specimens of 319 patients with adenomyosis admitted between January 1, 2014 and August 1, 2017 was performed. The endometrial and myometrial lesions coexisting with adenomyosis were evaluated. The clinicopathological prognostic factors, including tumor grade, myometrial invasion, lymphovascular space involvement, lymph node invasion, pathological stage and recurrence, were analysed...
August 2018: Molecular and Clinical Oncology
Zoe Garoufalia, Nikolaos Machairas, Ioannis D Kostakis, Aliki Liakea, Petros Tsaparas, George Liapis, Georgios C Sotiropoulos
Hepatic epithelioid angiomyolipoma (HEAML) is a rare mesenchymal tumor that has been reported to have malignant potential. We herein describe a rare case of atypical HEAML. A 43-year-old Caucasian male patient visited his general practitioner due to a productive cough persisting for >2 months. During evaluation with several imaging tests, a chest computed tomography (CT) incidentally revealed a well-demarcated lesion in the caudate lobe of the liver, sized 7 cm. An abdominal magnetic resonance imaging examination confirmed the findings of the CT...
August 2018: Molecular and Clinical Oncology
Tianyou Yang, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Jiahao Li, Tao Xu, Yan Zou
Traditionally, ruptured hepatoblastoma is considered a high-risk occurrence, necessitating a chemotherapy regimen usually consisting of cisplatin alternating with carboplatin plus doxorubicin, based on International Childhood Liver Tumours Strategy Group studies. However, ruptured hepatoblastomas with intact hepatic capsules may represent a unique subgroup that may be successfully treated with TAE, cisplatin monotherapy, and surgical excision. We herein present a case of ruptured hepatoblastoma (pretreatment tumor extension stage II) in a 1-year-old female patient that was successfully managed with transarterial embolization (TAE), eight courses of cisplatin chemotherapy and surgical removal...
August 2018: Molecular and Clinical Oncology
Anna Paspala, Nikolaos Machairas, Anastasia Prodromidou, Eleftherios Spartalis, Argyrios Ioannidis, Ioannis D Kostakis, Dimetrios Papaconstantinou, Nikolaos Nikiteas
Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathological diagnosis recently acknowledged by the World Health Organization in 2010. MANEC is a neoplasm characterized by significant histological heterogeneity and is characterized by the simultaneous presence of both adenocarcinomatous and neuroendocrine differentiation; their definition includes each component found in at least 30% of the tumor. Colorectal MANEC constitutes an uncommon type of malignant tumor. The true prevalence of colorectal MANEC has not been precisely defined and published studies are limited to case reports and small case series...
August 2018: Molecular and Clinical Oncology
Tamaki Tamanuki, Tomoyoshi Aoyagi, Akiyuki Murano, Hiroshi Matsuzaki
An 83-year-old woman underwent mastectomy for breast cancer of the right breast in 2008. In addition to hormone therapy and irradiation, zoledronate was started for bone metastasis 6 months postoperatively. Five years after the operation, the patient developed osteonecrosis of the jaw, and underwent sequestrectomy because of uncontrollable pain in the mandible. The patient visited our hospital for a 1-week history of fever and right facial swelling with pain, and was diagnosed with right mandibular cellulitis...
August 2018: Molecular and Clinical Oncology
Ji Hye Kim, Hee Jeong Cha, Kyu-Rae Kim, Kyungbin Kim
Signet ring cell carcinoma (SRCC) of the ovary is most commonly metastatic from a primary lesion. Primary ovarian SRCC is rare, and the distinction between primary and metastatic SRCC of the ovary may be difficult. We herein present a case of primary SRCC of the ovary in a 54-year-old woman presenting with a right ovarian mass sized 20.5×16.5×11.5 cm. Total abdominal hysterectomy with bilateral salpingo-oophorectomy, partial omentectomy and incidental appendectomy were performed. Upon histological examination, mucinous carcinoma composed predominantly of signet ring cells was observed in the right ovary...
August 2018: Molecular and Clinical Oncology
Kazuhiko Hashimoto, Shunji Nishimura, Naohiro Oka, Ryosuke Kakinoki, Masao Akagi
Despite the increasing incidence of tuberculosis, even in developed countries like Japan, tuberculoma is a relatively uncommon disease. Furthermore, given the rarity of tuberculoma, a definitive diagnosis is often delayed. We herein present the case of a 79-year-old man who presented with an erythematous and warm mass in the left forearm. Radiography revealed calcification of the wrist's volar side, and magnetic resonance imaging revealed a mosaic pattern at the lesion. Soft tissue sarcoma of the wrist was suspected, and an incisional biopsy was performed, which revealed numerous yellow rice bodies...
August 2018: Molecular and Clinical Oncology
M Kimura, F Yasue, E Usami, S Kawachi, M Iwai, M Go, Y Ikeda, T Yoshimura
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), including gefitinib, erlotinib and afatinib are standard first-line treatments for EGFR gene mutation-positive non-small cell lung cancer. The present study aimed to compare the cost-effectiveness of using erlotinib, afatinib or gefitinib. The safety of EGFR-TKIs was also investigated. Expected costs were calculated based on data from patients with advanced EGFR mutation-positive non-small-cell lung cancer who were treated with gefitinib, erlotinib or afatinib...
August 2018: Molecular and Clinical Oncology
Jia Hu, Tao He, Lu Jin, Yifan Li, Yang Zhao, Wenhua Li, Benlin Wei, Xiang Ming Mao, Yong Qing Lai, Liang Chao Ni
The incidence of prostatic cancer (PCa) has increased significantly, and the measurement of prostate-specific antigen (PSA) is an effective screening tool for its diagnosis. PCa includes a number of specific clinicopathological types, including squamous cell, urothelial, adenoid cystic and small-cell carcinoma, among which small-cell carcinoma of the prostate (SCCP) is extremely rare, accounting for <0.5% of all PCa cases. SCCP is very aggressive and the majority of the cases have a poor prognosis, with a mean survival of ~5 months; it also exhibits specific clinicopathological characteristics and may be divided into two subtypes, namely pure and mixed SCCP...
August 2018: Molecular and Clinical Oncology
Xian Wen Sun, Yong Jie Ding, Yu Yan Zhang, Pei Li Chen, Ya Ru Yan, Ji Min Shen, Qing Yun Li
Invasive mucinous adenocarcinoma (IMA) was formerly referred to as mucinous bronchioloalveolar carcinoma. The lack of effective chemotherapy and comprehensive treatment for this type of tumor poses a great challenge in clinical practice. We herein report the case of a male patient with IMA who was treated with a combination of pemetrexed (500 mg/m2 ), cisplatin (75 mg/m2 ) and bevacizumab (15 mg/kg) as first-line chemotherapy. The patient achieved significant radiological improvement with 6 courses of this regimen...
August 2018: Molecular and Clinical Oncology
Naoto Oebisu, Manabu Hoshi, Makoto Ieguchi, Tadashi Iwai, Sayaka Tanaka, Masahiko Osawa, Hiroaki Nakamura
Methotrexate (MTX) is the key drug for the treatment of rheumatoid arthritis (RA). MTX-treated RA has been associated with the development of lymphoproliferative disorders (LPDs). Notably, the hyperimmune state of RA itself or the immunosuppressive state induced by MTX administration may contribute to development of LPD. Furthermore, Epstein-Barr virus (EBV) has been indicated to contribute to the development of MTX-LPD. MTX-associated LPD (MTX-LPD) may affect nodal or extranodal sites, including the gastrointestinal tract, skin, lungs, kidneys, and soft tissues, at an almost equal frequency...
August 2018: Molecular and Clinical Oncology
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