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Molecular and Clinical Oncology

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https://www.readbyqxmd.com/read/30279989/clinical-factors-affecting-perioperative-outcomes-in-robot-assisted-radical-prostatectomy
#1
Tomohiko Murakami, Satoshi Otsubo, Ryo Namitome, Masaki Shiota, Junichi Inokuchi, Ario Takeuchi, Eiji Kashiwagi, Katsunori Tatsugami, Masatoshi Eto
The present study investigated clinical factors affecting perioperative outcomes in robot-assisted radical prostatectomy (RARP). The study included 625 Japanese cases treated with RARP between 2009 and 2017. The association between clinical factors (age, overweight status, prostate volume, clinical T-stage, nerve sparing, lympho-node dissection, and the number of experienced cases) and perioperative outcomes (operation time, estimated blood loss, catheterization duration, and perioperative complication) were analyzed...
November 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233800/high-promoter-activity-of-cytokeratin-19-gene-in-cholangiocarcinoma
#2
Jian Qin, Min Wang, Jun Qin, Qu Cai, Zhi-Hai Peng
Conditionally replicating adenoviral vectors constructed with tumor-specific promoters (TSPs) offers a viable tool for the treatment of cholangiocarcinoma. The aim of the present study was to investigate cholangiocarcinoma-specific TSPs that remain active in adenoviral constructs in gene therapy. The mRNA expressions of cyclooxygenase-2, cytokeratin-19 (CK19), mucin-1, midkine and telomerase reverse transcriptase were determined in human cholangiocarcinoma cell lines, primary human hepatocytes and cholangiocytes using reverse transcription-quantitative polymerase chain reaction...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233799/intra-articular-synovial-sarcoma-in-the-ankle-joint-a-case-report
#3
Tomoki Nakamura, Tomohito Hagi, Kunihiro Asanuma, Akihiro Sudo
Intra-articular primary soft tissue sarcomas are extremely rare. The present case report describes a case of intra-articular synovial sarcoma of the ankle joint. A 51-year-old man presented with complaints of swelling and progressive pain in the right ankle. Lateral radiographs of the ankle revealed lytic invasion of the anterior and posterior parts of the talus. Computed tomography imaging revealed a low-density lesion with calcifications around the ankle joint. Magnetic resonance imaging revealed that the diffuse lesion was isointense on T1-weighted images and hypointense to hyperintense on T2-weighted images...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233798/diagnoses-of-suspected-cancer-in-otolaryngology-practices-in-germany
#4
Karel Kostev, Maike Lasrich, Lisa Schüller, Isabel Diogo, Andreas Sesterhenn, Louis Jacob
The aim of this study was to estimate the prevalence of suspected head and neck cancer (HNC) diagnoses made by otolaryngologists in a population with subsequently confirmed cancer diagnoses in Germany. This study included patients with an initial documentation of confirmed cancer diagnosis made in 137 otolaryngology practices between January 2012 and December 2016 (index date). The main outcome of the study was the prevalence of diagnoses of suspected cancer in otolaryngology practices within one year prior to the first documentation of a confirmed cancer diagnosis...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233797/prognostic-significance-of-pre-treatment-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-glioblastoma
#5
Özlem Yersal, Eylem Odabaşi, Özge Özdemir, Yasemin Kemal
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumour in adults. Identification of accessible and cost-effective prognostic factors may better guide adjuvant treatment-related decisions. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers of host inflammatory response, and their increase has recently been shown to be a poor prognostic factor in several malignancies. The aim of the present study was to investigate the prognostic value of preoperative NLR and PLR in GBM patients...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233796/red-nodular-melanoma-of-the-penile-foreskin-a-case-report-and-literature-review
#6
Yuki Maruyama, Takuya Sadahira, Yosuke Mitsui, Koichiro Wada, Ryuta Tanimoto, Yasuyuki Kobayashi, Motoo Araki, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu
The penis is an extremely rare primary site for malignant melanomas, and the clinical presentation may vary greatly. We herein present the case of a 71-year-old male patient who presented with a 6-year history of two slow growing, asymptomatic red macules on the penile foreskin. On physical examination, the mobility of the foreskin was good, and there was no metastasis on computed tomography and magnetic resonance imaging. The patient underwent segmental circumcision for treatment and histological diagnosis, and the histological examination revealed a malignant melanoma...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233795/radiation-induced-glioblastoma-with-rhabdoid-characteristics-following-treatment-for-medulloblastoma-a-case-report-and-review-of-the-literature
#7
Ying Wang, Shujun Song, Xiaoming Su, Jihua Wu, Zhuojie Dai, Di Cui, Ye Reng, Jingjing Fan, Yulong Shen, Qingqin Wu, Zongye Wang
Glioblastoma multiforme (GBM) is a high-grade glioma that may develop from several other central nervous system tumors after radiation therapy. We herein report a case of GBM occurring 8 years after radiation therapy for medulloblastoma. The secondary tumor was histologically distinctly different from the primary tumor. Previously reported cases indicate that GBM induced by radiation therapy is associated with a highly aggressive clinical course with a high risk of early recurrence and poor prognosis. In addition, histological examination revealed that the tumor cells exhibited characteristics of both GBM and rhabdoid tumor cells...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233794/evaluation-of-inflammation-based-markers-for-predicting-the-prognosis-of-unresectable-pancreatic-ductal-adenocarcinoma-treated-with-chemotherapy
#8
Hiroyuki Asama, Rei Suzuki, Tadayuki Takagi, Mitsuru Sugimoto, Naoki Konno, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Mika Takasumi, Yuki Sato, Hiroki Irie, Takuto Hikichi, Hiromasa Ohira
Predicting the prognosis of unresectable pancreatic ductal adenocarcinoma (PDAC) is useful in determining the appropriate management strategy. The present study aimed to investigate the association between PDAC prognosis and inflammation-based markers, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, prognostic nutritional index, modified Glasgow prognostic score (mGPS) and controlling nutritional status score. A total of 72 patients with unresectable PDAC who received chemotherapy were included...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233793/perforated-gastrointestinal-stromal-tumor-in-the-small-intestine-a-rare-case-of-torricelli-bernoulli-sign
#9
Takayuki Tajima, Takayuki Nishi, Mifuji Tomioku, Takashi Ogimi, Lin Fung Chan, Takashi Okazaki, Kazunori Myoujin, Hideo Shimada
The Torricelli-Bernoulli sign is a computed tomography (CT) finding that occurs when ulceration/necrosis of a submucosal gastrointestinal tumor releases a stream of air bubbles into the intestinal lumen. A 75-year-old man developed acute abdominal pain at night and presented to a local doctor. Acute abdomen was diagnosed and he was referred to the Emergency Department at Tokai University Oiso Hospital. On CT scans, disseminated intestinal tumor-like lesions were seen in the right lower abdomen. The Torricelli-Bernoulli sign and free intraabdominal gas were observed, so perforation of an intestinal tumor was diagnosed and emergency surgery was performed...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233792/neutrophil-to-lymphocyte-ratio-as-a-predictor-of-postoperative-morbidity-in-patients-with-distal-cholangiocarcinoma
#10
Yusuke Kumamoto, Takashi Kaizu, Hiroshi Tajima, Nobuyuki Nishizawa, Shigenori Ei, Kazuharu Igarashi, Masahiko Watanabe
Systemic inflammatory-, immunological- and nutritional-based indices, such as the neutrophil-to-lymphocyte ratio (NLR), the prognostic nutritional index (PNI) and the Glasgow prognostic score (GPS), are drawing considerable research attention to predict the long-term prognosis of many types of cancer. Recently, these parameters have also been reported to be useful in predicting postoperative morbidity in several fields, including colorectal and otolaryngological cancer. However, while distal cholangiocarcinoma exhibits a high morbidity rate, its risk factors of morbidity have not yet been established...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30233791/the-role-of-automated-cytometry-in-the-new-era-of-cancer-immunotherapy
#11
REVIEW
Marco Danova, Martina Torchio, Giuditta Comolli, Andrea Sbrana, Andrea Antonuzzo, Giuliano Mazzini
The introduction in the clinical practice of several new approaches to cancer immunotherapy has greatly increased the interest in analytical methodologies that can define the immunological profile of patients in the clinical setting. This requires huge effort to obtain reliable monitoring tools that could be used to improve the patient's clinical outcome. The clinical applications of flow cytometry (FCM) in oncology started with the measurement of DNA content for the evaluation of both ploidy and cell cycle profile as potential prognostic parameters in the majority of human solid cancer types...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214735/efficacy-of-vemurafenib-in-a-heavy-smoker-with-braf-mutated-lung-adenocarcinoma-a-case-report-and-literature-review
#12
Xue Liu, Xuefeng Fang, Hanguang Hu, Xianhua Fu, Ying Chen, Ying Yuan
At present, research on BRAF gene mutations appears to be mainly focused on melanoma rather than non-small-cell lung cancer (NSCLC). We herein describe the case of a patient with BRAF V600E-mutated advanced NSCLC, whose symptoms were relieved and computed tomography imaging revealed partial response to vemurafenib following failure of chemotherapy. This case demonstrates the promising prospects of BRAF inhibitor treatment in patients with BRAF-mutated NSCLC. Targeted therapies have significantly modified the treatment of NSCLC...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214734/a-cross-sectional-survey-of-methods-for-controling-hand-foot-syndrome-in-patients-receiving-capecitabine-treatment
#13
Shinya Suzuki, Shuichi Nawata, Yusuke Inada, Daisuke Sato, Junichi Kusano, Daisuke Ichikura, Kazuhiro Torigoe, Kazumi Ishitsuka, Fumiaki Sato, Hiroyasu Sakai, Tetsuro Yumoto
Medical personnel actively provide patients taking capecitabine with information on the items to prevent and treat hand-foot syndrome (HFS). However, they are typically unable to ascertain the extent of patient compliance with the recommended items. Thus, the aim of the present study was to ascertain the association between patient compliance with preventative measures for HFS and the development of HFS. Subjects included 90 patients who were treated with a drug regimen that included capecitabine. Patients were treated at one of four facilities between July 2015 and January 2017...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214733/primary-adrenal-teratoma-a-case-series-and-review-of-the-literature
#14
Liang Zhou, Xiang Pan, Tao He, Yulin Lai, Wenhua Li, Yiming Hu, Liangchao Ni, Shangqi Yang, Yun Chen, Yongqing Lai
Primary adrenal teratoma is a rare type of cancer. Of the 338 patients who underwent adrenalectomy during this study, only 2 (aged 69 and 29 years) were diagnosed with adrenal teratoma and underwent laparoscopic retroperitoneal adrenalectomy. For the purposes of the present study, the term 'adrenal teratoma' was searched in the PubMed database, and 237 articles published between June 1952 and March 2017 were retrieved. However, we were only able to identify 10 relevant studies. In total, these studies reported a series of 18 cases of primary adrenal teratoma in patients aged >16 years, another 8 cases of adult adrenal retroperitoneal teratoma, and 7 cases of adrenal teratoma in children aged <16 years...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214732/incidental-discovery-of-mucinous-adenocarcinoma-of-the-prostate-following-transurethral-resection-of-the-prostate-a-report-of-two-cases-and-a-literature-review
#15
Lijie Zhang, Lihua Zhang, Ming Chen, Quan Fang
Mucinous carcinoma is an unusual subtype of prostate cancer. In particular, mucinous adenocarcinomas identified following transurethral resection of the prostate (TURP) are extremely rare. The present study conducted are retrospective analysis of two cases of mucinous carcinoma of the prostate, which were incidentally diagnosed following histological examination of the specimens obtained by TURP. The pathological findings, treatment regimen and clinical course of the two cases were reviewed. One of the patients, whose surgical specimen stained positive for carcinoembryonic antigen (CEA) and negative for prostate-specific antigen (PSA), did not respond to androgen deprivation therapy (ADT)...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214731/superiority-of-the-8th-edition-of-the-tnm-staging-system-for-predicting-overall-survival-in-gastric-cancer-comparative-analysis-of-the-7th-and-8th-editions-in-a-monoinstitutional-cohort
#16
Hao Wang, Weihong Guo, Yanfeng Hu, Tingyu Mou, Liying Zhao, Hao Chen, Tian Lin, Tuanjie Li, Jiang Yu, Hao Liu, Guoxin Li
The present study was performed to evaluate the predictive capacity of the 8th edition vs. the 7th edition of the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging system for overall survival (OS) of patients with gastric cancer. Data of eligible patients with gastric cancer in our institution between June 2004 and June 2014 were retrospectively reviewed. A total of 1,506 patients were followed up to July 2016, among whom 1,484 patients with complete stage information were included in the TNM staging analysis...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214730/efficacy-and-safety-of-nivolumab-in-non-small-cell-lung-cancer-patients-in-tel-aviv-tertiary-medical-center-facing-the-reality
#17
Sivan Shamai, Ofer Merimsky
Nivolumab is a human IgG4 programmed death (PD)-1 immune checkpoint inhibitor antibody, which is approved in Israel for the treatment of patients with advanced non-small cell lung cancer (NSCLC). It is also administered to individuals with disease progression during or after platinum-based chemotherapy, without a need to determine the level of PD-L1 expression in the tumor. The present study aimed to evaluate the survival and efficacy of Nivolumab treatment. A retrospective analysis was performed at a thoracic oncology service in a tertiary referral center (Tel-Aviv Sourasky Medical Center), on patients with NSCLC (squamous and non-squamous)...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214729/acute-necrotizing-pancreatitis-as-a-fatal-complication-following-dc-bead-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma-a-case-report-and-review-of-the-literature
#18
Takashi Yamaguchi, Toshihito Seki, Atsushi Komemushi, Kanehiko Suwa, Rinako Tsuda, Ryosuke Inokuchi, Miki Murata, Michiko Yuki, Yoko Harima, Kazuichi Okazaki
Transcatheter arterial chemoembolization (TACE) is one of the most effective palliative measures for patients with inoperable hepatocellular carcinoma (HCC). Acute pancreatitis is a rare but well-known complication following TACE. We herein present the case of a patient with HCC who developed fatal complications (acute necrotizing pancreatitis and upper gastrointestinal ulcers) after TACE with DC Beads. The patient was diagnosed with HCC in segments 4 and 8, measuring ~70 mm in greatest diameter, and he was treated by TACE...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214728/efficacy-and-safety-of-sunitinib-in-elderly-patients-with-advanced-renal-cell-carcinoma
#19
Tetsuo Fujita, Takahiro Hirayama, Daisuke Ishii, Kazumasa Matsumoto, Kazunari Yoshida, Masatsugu Iwamura
Elderly individuals represent a consistent proportion of all cancer patients. However, they are under-represented in clinical trials. The present study evaluated the actual tolerability of sunitinib in elderly Japanese patients with advanced renal cell carcinoma (RCC). A total of 56 consecutive patients with advanced RCC treated with sunitinib were enrolled. Patients were divided into two groups according to their age at the time of sunitinib initiation: i) elderly cohort (≥70 years); and ii) younger cohort (<70 years)...
October 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30214727/conversion-surgery-with-gemcitabine-plus-nab-paclitaxel-for-locally-advanced-unresectable-pancreatic-cancer-a-case-report
#20
Ryosuke Okura, Shigetsugu Takano, Tetsuo Yokota, Hideyuki Yoshitomi, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Hiroyuki Nojima, Takashi Mishima, Masaru Miyazaki, Masayuki Ohtsuka
The standard treatment for locally advanced unresectable (UR-LA) pancreatic ductal adenocarcinoma (PDAC) is chemo-radiotherapy. Surgery following chemo-radiotherapy (conversion surgery), has been considered a useful strategy and has been used for UR-LA PDAC. The current study presents the case of a 43-year-old woman who complained of back pain. A radiological examination revealed a pancreatic tumor in contact with >270 degrees of the superior mesenteric artery (SMA) perimeter, with invasion extending from the superior mesenteric vein (SMV) to the portal vein (PV)...
October 2018: Molecular and Clinical Oncology
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