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Journal of Developmental Biology

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https://www.readbyqxmd.com/read/30011921/specification-and-patterning-of-drosophila-appendages
#1
REVIEW
Mireya Ruiz-Losada, David Blom-Dahl, Sergio Córdoba, Carlos Estella
Appendages are external projections of the body that serve the animal for locomotion, feeding, or environment exploration. The appendages of the fruit fly Drosophila melanogaster are derived from the imaginal discs, epithelial sac-like structures specified in the embryo that grow and pattern during larva development. In the last decades, genetic and developmental studies in the fruit fly have provided extensive knowledge regarding the mechanisms that direct the formation of the appendages. Importantly, many of the signaling pathways and patterning genes identified and characterized in Drosophila have similar functions during vertebrate appendage development...
July 14, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29949945/forced-expression-of-foxg1-in-the-cortical-hem-leads-to-the-transformation-of-cajal-retzius-cells-into-dentate-granule-neurons
#2
Bin Liu, Hongmei Xiao, Chunjie Zhao
The Wnt- and BMP-rich cortical hem has been demonstrated to be critical for the pattern formation of the telencephalon, and it is particularly important for the induction of the hippocampus. Meanwhile, the cortical hem is one of the sources of Cajal-Retzius cells. Many Cajal-Retzius cells are produced in the hem and populated to the media-caudal surface of the telencephalon. However, the mechanism of the maintenance of the hem remain unclear. In this study, we generated a transgenic mouse line CAG-loxp-stop-loxp-Foxg1-IRES-EGFP ...
June 26, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29933588/the-impact-of-two-different-cold-extruded-feeds-and-feeding-regimens-on-zebrafish-survival-growth-and-reproductive-performance
#3
Joana F Monteiro, Sandra Martins, Matheus Farias, Telma Costa, Ana Catarina Certal
Zebrafish ( Danio rerio ) is one of the top model organisms used in biomedical research. Therefore, it is fundamental that zebrafish facilities continuously improve husbandry methods to provide fish with the best physiological and welfare conditions that suit each experimental purpose. Nutrition is a husbandry aspect that needs further optimization, as it greatly affects growth, reproduction, health and behaviour. Here, we have compared the impact of different feeding regimens on zebrafish survival, growth and reproductive performance...
June 21, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29914150/unanswered-questions-regarding-sex-and-bmp-tgf-%C3%AE-signaling
#4
REVIEW
Tapan A Shah, Melissa B Rogers
Crosstalk between the BMP and TGF-β signaling pathways regulates many complex developmental processes from the earliest stages of embryogenesis throughout adult life. In many situations, the two signaling pathways act reciprocally. For example, TGF-β signaling is generally pro-fibrotic, whereas BMP signaling is anti-fibrotic and pro-calcific. Sex-specific differences occur in many diseases including cardiovascular pathologies. Differing ratios of fibrosis and calcification in stenotic valves suggests that BMP/TGF-β signaling may vary in men and women...
June 16, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29914077/lhx2-mediates-the-fgf-to-shh-regulatory-loop-during-limb-development
#5
Billy A Watson, Jennifer M Feenstra, Jonathan M Van Arsdale, Karndeep S Rai-Bhatti, Diana J H Kim, Ashley S Coggins, Gennaya L Mattison, Stephen Yoo, Eric D Steinman, Charmaine U Pira, Brendan R Gongol, Kerby C Oberg
During limb development, fibroblast growth factors (Fgfs) govern proximal⁻distal outgrowth and patterning. FGFs also synchronize developmental patterning between the proximal⁻distal and anterior⁻posterior axes by maintaining Sonic hedgehog (Shh) expression in cells of the zone of polarizing activity (ZPA) in the distal posterior mesoderm. Shh, in turn, maintains Fgfs in the apical ectodermal ridge (AER) that caps the distal tip of the limb bud. Crosstalk between Fgf and Shh signaling is critical for patterned limb development, but the mechanisms underlying this feedback loop are not well-characterized...
June 15, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29890674/sonic-hedgehog-is-a-member-of-the-hh-dd-peptidase-family-that-spans-the-eukaryotic-and-bacterial-domains-of-life
#6
REVIEW
Henk Roelink
Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic activity results in more stable forms of Shh. The residues involved in Zn2+ coordination in Shh are found to be mutated in some individuals with the congenital birth defect holoprosencephaly, demonstrating their importance in development. Highly conserved Shh domains are found in parts of some bacterial proteins that are members of the larger family of DD-peptidases, supporting the notion that Shh acts as a peptidase...
June 8, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29783715/location-location-location-signals-in-muscle-specification
#7
REVIEW
Chih-Ning Chang, Chrissa Kioussi
Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific time and space. Although the anatomical structure of skeletal muscles is similar, their functions and locations are specialized. This is the result of specific signaling as the embryo grows and cells migrate to form different structures and organs. As cells progress to their next state, they suppress current sequence specific transcription factors (SSTF) and construct new networks to establish new myogenic features...
May 18, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29734755/interview-with-the-2018-jdb-travel-award-winner
#8
EDITORIAL
(no author information available yet)
The winner of the 2018 JDB Travel Award was granted to Ms. Victoria Deneke, BS, who is a fifth-year graduate student in Dr. Stefano Di Talia’s laboratory in the Department of Cell Biology at Duke University Medical Center, USA.[…].
May 5, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615558/requirement-of-the-dynein-adaptor-spindly-for-mitotic-and-post-mitotic-functions-in-drosophila
#9
Giuliana D Clemente, Matthew R Hannaford, Hamze Beati, Katja Kapp, Jens Januschke, Eric R Griffis, Hans-Arno J Müller
Spindly was originally identified as a specific regulator of Dynein activity at the kinetochore. In early prometaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions and progression into anaphase. While details of Spindly function in mitosis have been worked out in cultured human cells and in the C. elegans zygote, the function of Spindly within the context of an organism has not yet been addressed. Here, we present loss- and gain-of-function studies of Spindly using transgenic RNAi in Drosophila ...
March 30, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615557/wingless-wnt-signaling-in-intestinal-development-homeostasis-regeneration-and-tumorigenesis-a-drosophila-perspective
#10
REVIEW
Ai Tian, Hassina Benchabane, Yashi Ahmed
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis...
March 28, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615556/ethanol-exposure-causes-muscle-degeneration-in-zebrafish
#11
Elizabeth C Coffey, Maggie E Pasquarella, Michelle F Goody, Clarissa A Henry
Alcoholic myopathies are characterized by neuromusculoskeletal symptoms such as compromised movement and weakness. Although these symptoms have been attributed to neurological damage, EtOH may also target skeletal muscle. EtOH exposure during zebrafish primary muscle development or adulthood results in smaller muscle fibers. However, the effects of EtOH exposure on skeletal muscle during the growth period that follows primary muscle development are not well understood. We determined the effects of EtOH exposure on muscle during this phase of development...
March 9, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615555/imaging-neuronal-activity-in-the-optic-tectum-of-late-stage-larval-zebrafish
#12
Katharina Bergmann, Paola Meza Santoscoy, Konstantinos Lygdas, Yulia Nikolaeva, Ryan B MacDonald, Vincent T Cunliffe, Anton Nikolaev
The zebrafish is an established model to study the development and function of visual neuronal circuits in vivo, largely due to their optical accessibility at embryonic and larval stages. In the past decade multiple experimental paradigms have been developed to study visually-driven behaviours, particularly those regulated by the optic tectum, the main visual centre in lower vertebrates. With few exceptions these techniques are limited to young larvae (7-9 days post-fertilisation, dpf). However, many forms of visually-driven behaviour, such as shoaling, emerge at later developmental stages...
March 9, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615554/flying-the-rna-nest-drosophila-reveals-novel-insights-into-the-transcriptome-dynamics-of-early-development
#13
REVIEW
Fabio Alexis Lefebvre, Éric Lécuyer
Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new organism. Specifically, developmental transitions that ensure the maternal to embryonic control of developmental events entail a deep remodeling of transcriptional and transcriptomic landscapes. Drosophila provides an elegant and genetically tractable system to investigate these conserved changes at a dazzling developmental pace...
March 7, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615553/dynamic-tissue-rearrangements-during-vertebrate-eye-morphogenesis-insights-from-fish-models
#14
REVIEW
Florencia Cavodeassi
Over the last thirty years, fish models, such as the zebrafish and medaka, have become essential to pursue developmental studies and model human disease. Community efforts have led to the generation of wide collections of mutants, a complete sequence of their genomes, and the development of sophisticated genetic tools, enabling the manipulation of gene activity and labelling and tracking of specific groups of cells during embryonic development. When combined with the accessibility and optical clarity of fish embryos, these approaches have made of them an unbeatable model to monitor developmental processes in vivo and in real time...
February 28, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615552/taking-the-occam-s-razor-approach-to-hedgehog-lipidation-and-its-role-in-development
#15
REVIEW
Dominique Manikowski, Philipp Kastl, Kay Grobe
All Hedgehog (Hh) proteins signal from producing cells to distant receiving cells despite being synthesized as N-and C-terminally lipidated, membrane-tethered molecules. To explain this paradoxical situation, over the past 15 years, several hypotheses have been postulated that tie directly into this property, such as Hh transport on cellular extensions called cytonemes or on secreted vesicles called lipophorins and exosomes. The alternative situation that tight membrane association merely serves to prevent unregulated Hh solubilization has been addressed by biochemical and structural studies suggesting Hh extraction from the membrane or proteolytic Hh release...
January 30, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615551/the-biology-of-sumo-targeted-ubiquitin-ligases-in-drosophila-development-immunity-and-cancer
#16
REVIEW
Mona Abed, Eliya Bitman-Lotan, Amir Orian
The ubiquitin and SUMO (small ubiquitin-like modifier) pathways modify proteins that in turn regulate diverse cellular processes, embryonic development, and adult tissue physiology. These pathways were originally discovered biochemically in vitro, leading to a long-standing challenge of elucidating both the molecular cross-talk between these pathways and their biological importance. Recent discoveries in Drosophila established that ubiquitin and SUMO pathways are interconnected via evolutionally conserved SUMO-targeted ubiquitin ligase (STUbL) proteins...
January 1, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615550/modeling-alzheimer-s-and-other-age-related-human-diseases-in-embryonic-systems
#17
Chu Hsien Lim, Ajay S Mathuru
Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer's disease in Drosophila melanogaster , Caenorhabditis elegans , and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease.
December 22, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615573/ttc21b-is-required-in-bergmann-glia-for-proper-granule-cell-radial-migration
#18
Ashley M Driver, Christopher Shumrick, Rolf W Stottmann
Proper cerebellar development is dependent on tightly regulated proliferation, migration, and differentiation events. Disruptions in any of these leads to a range of cerebellar phenotypes from ataxia to childhood tumors. Animal models have shown that proper regulation of sonic hedgehog ( Shh ) signaling is crucial for normal cerebellar architecture, and increased signaling leads to cerebellar tumor formation. Primary cilia are known to be required for the proper regulation of multiple developmental signaling pathways, including Shh ...
December 19, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615572/the-role-of-hedgehog-signalling-in-the-formation-of-the-ventricular-septum
#19
REVIEW
Antonia Wiegering, Ulrich Rüther, Christoph Gerhardt
An incomplete septation of the ventricles in the vertebrate heart that disturbes the strict separation between the contents of the two ventricles is termed a ventricular septal defect (VSD). Together with bicuspid aortic valves, it is the most frequent congenital heart disease in humans. Until now, life-threatening VSDs are usually treated surgically. To avoid surgery and to develop an alternative therapy (e.g., a small molecule therapy), it is necessary to understand the molecular mechanisms underlying ventricular septum (VS) development...
December 12, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615571/engineering-the-drosophila-genome-for-developmental-biology
#20
REVIEW
Dagmara Korona, Stefan A Koestler, Steven Russell
The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes. Tools for introducing tags into genes at their endogenous genomic loci facilitate imaging or biochemistry approaches at the cellular or subcellular levels. Similarly, the ability to make specific alterations to the genome sequence allows much more precise genetic control to address questions of gene function.
December 11, 2017: Journal of Developmental Biology
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