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Journal of Developmental Biology

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https://www.readbyqxmd.com/read/29734755/interview-with-the-2018-jdb-travel-award-winner
#1
EDITORIAL
(no author information available yet)
The winner of the 2018 JDB Travel Award was granted to Ms. Victoria Deneke, BS, who is a fifth-year graduate student in Dr. Stefano Di Talia’s laboratory in the Department of Cell Biology at Duke University Medical Center, USA.[…].
May 5, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615558/requirement-of-the-dynein-adaptor-spindly-for-mitotic-and-post-mitotic-functions-in-drosophila
#2
Giuliana D Clemente, Matthew R Hannaford, Hamze Beati, Katja Kapp, Jens Januschke, Eric R Griffis, Hans-Arno J Müller
Spindly was originally identified as a specific regulator of Dynein activity at the kinetochore. In early prometaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions and progression into anaphase. While details of Spindly function in mitosis have been worked out in cultured human cells and in the C. elegans zygote, the function of Spindly within the context of an organism has not yet been addressed. Here, we present loss- and gain-of-function studies of Spindly using transgenic RNAi in Drosophila ...
March 30, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615557/wingless-wnt-signaling-in-intestinal-development-homeostasis-regeneration-and-tumorigenesis-a-drosophila-perspective
#3
REVIEW
Ai Tian, Hassina Benchabane, Yashi Ahmed
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis...
March 28, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615556/ethanol-exposure-causes-muscle-degeneration-in-zebrafish
#4
Elizabeth C Coffey, Maggie E Pasquarella, Michelle F Goody, Clarissa A Henry
Alcoholic myopathies are characterized by neuromusculoskeletal symptoms such as compromised movement and weakness. Although these symptoms have been attributed to neurological damage, EtOH may also target skeletal muscle. EtOH exposure during zebrafish primary muscle development or adulthood results in smaller muscle fibers. However, the effects of EtOH exposure on skeletal muscle during the growth period that follows primary muscle development are not well understood. We determined the effects of EtOH exposure on muscle during this phase of development...
March 9, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615555/imaging-neuronal-activity-in-the-optic-tectum-of-late-stage-larval-zebrafish
#5
Katharina Bergmann, Paola Meza Santoscoy, Konstantinos Lygdas, Yulia Nikolaeva, Ryan B MacDonald, Vincent T Cunliffe, Anton Nikolaev
The zebrafish is an established model to study the development and function of visual neuronal circuits in vivo, largely due to their optical accessibility at embryonic and larval stages. In the past decade multiple experimental paradigms have been developed to study visually-driven behaviours, particularly those regulated by the optic tectum, the main visual centre in lower vertebrates. With few exceptions these techniques are limited to young larvae (7-9 days post-fertilisation, dpf). However, many forms of visually-driven behaviour, such as shoaling, emerge at later developmental stages...
March 9, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615554/flying-the-rna-nest-drosophila-reveals-novel-insights-into-the-transcriptome-dynamics-of-early-development
#6
REVIEW
Fabio Alexis Lefebvre, Éric Lécuyer
Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new organism. Specifically, developmental transitions that ensure the maternal to embryonic control of developmental events entail a deep remodeling of transcriptional and transcriptomic landscapes. Drosophila provides an elegant and genetically tractable system to investigate these conserved changes at a dazzling developmental pace...
March 7, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615553/dynamic-tissue-rearrangements-during-vertebrate-eye-morphogenesis-insights-from-fish-models
#7
REVIEW
Florencia Cavodeassi
Over the last thirty years, fish models, such as the zebrafish and medaka, have become essential to pursue developmental studies and model human disease. Community efforts have led to the generation of wide collections of mutants, a complete sequence of their genomes, and the development of sophisticated genetic tools, enabling the manipulation of gene activity and labelling and tracking of specific groups of cells during embryonic development. When combined with the accessibility and optical clarity of fish embryos, these approaches have made of them an unbeatable model to monitor developmental processes in vivo and in real time...
February 28, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615552/taking-the-occam-s-razor-approach-to-hedgehog-lipidation-and-its-role-in-development
#8
REVIEW
Dominique Manikowski, Philipp Kastl, Kay Grobe
All Hedgehog (Hh) proteins signal from producing cells to distant receiving cells despite being synthesized as N-and C-terminally lipidated, membrane-tethered molecules. To explain this paradoxical situation, over the past 15 years, several hypotheses have been postulated that tie directly into this property, such as Hh transport on cellular extensions called cytonemes or on secreted vesicles called lipophorins and exosomes. The alternative situation that tight membrane association merely serves to prevent unregulated Hh solubilization has been addressed by biochemical and structural studies suggesting Hh extraction from the membrane or proteolytic Hh release...
January 30, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615551/the-biology-of-sumo-targeted-ubiquitin-ligases-in-drosophila-development-immunity-and-cancer
#9
REVIEW
Mona Abed, Eliya Bitman-Lotan, Amir Orian
The ubiquitin and SUMO (small ubiquitin-like modifier) pathways modify proteins that in turn regulate diverse cellular processes, embryonic development, and adult tissue physiology. These pathways were originally discovered biochemically in vitro, leading to a long-standing challenge of elucidating both the molecular cross-talk between these pathways and their biological importance. Recent discoveries in Drosophila established that ubiquitin and SUMO pathways are interconnected via evolutionally conserved SUMO-targeted ubiquitin ligase (STUbL) proteins...
January 1, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615550/modeling-alzheimer-s-and-other-age-related-human-diseases-in-embryonic-systems
#10
Chu Hsien Lim, Ajay S Mathuru
Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer's disease in Drosophila melanogaster , Caenorhabditis elegans , and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease.
December 22, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615573/ttc21b-is-required-in-bergmann-glia-for-proper-granule-cell-radial-migration
#11
Ashley M Driver, Christopher Shumrick, Rolf W Stottmann
Proper cerebellar development is dependent on tightly regulated proliferation, migration, and differentiation events. Disruptions in any of these leads to a range of cerebellar phenotypes from ataxia to childhood tumors. Animal models have shown that proper regulation of sonic hedgehog ( Shh ) signaling is crucial for normal cerebellar architecture, and increased signaling leads to cerebellar tumor formation. Primary cilia are known to be required for the proper regulation of multiple developmental signaling pathways, including Shh ...
December 19, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615572/the-role-of-hedgehog-signalling-in-the-formation-of-the-ventricular-septum
#12
REVIEW
Antonia Wiegering, Ulrich Rüther, Christoph Gerhardt
An incomplete septation of the ventricles in the vertebrate heart that disturbes the strict separation between the contents of the two ventricles is termed a ventricular septal defect (VSD). Together with bicuspid aortic valves, it is the most frequent congenital heart disease in humans. Until now, life-threatening VSDs are usually treated surgically. To avoid surgery and to develop an alternative therapy (e.g., a small molecule therapy), it is necessary to understand the molecular mechanisms underlying ventricular septum (VS) development...
December 12, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615571/engineering-the-drosophila-genome-for-developmental-biology
#13
REVIEW
Dagmara Korona, Stefan A Koestler, Steven Russell
The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes. Tools for introducing tags into genes at their endogenous genomic loci facilitate imaging or biochemistry approaches at the cellular or subcellular levels. Similarly, the ability to make specific alterations to the genome sequence allows much more precise genetic control to address questions of gene function.
December 11, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615570/drosophila-as-a-model-to-study-the-link-between-metabolism-and-cancer
#14
REVIEW
Héctor Herranz, Stephen M Cohen
Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer...
December 1, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29214147/the-hedgehog-signaling-pathway-emerges-as-a-pathogenic-target
#15
Margery G Smelkinson
The Hedgehog (Hh) signaling pathway plays an essential role in the growth, development, and homeostatis of many tissues in vertebrates and invertebrates. Much of what is known about Hh signaling is in the context of embryonic development and tumor formation. However, a growing body of evidence is emerging indicating that Hh signaling is also involved in postnatal processes such as tissue repair and adult immune responses. To that extent, Hh signaling has also been shown to be a target for some pathogens that presumably utilize the pathway to control the local infected environment...
December 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615569/emerging-roles-of-dyrk-kinases-in-embryogenesis-and-hedgehog-pathway-control
#16
REVIEW
Rajeev Singh, Matthias Lauth
Hedgehog (Hh)/GLI signaling is an important instructive cue in various processes during embryonic development, such as tissue patterning, stem cell maintenance, and cell differentiation. It also plays crucial roles in the development of many pediatric and adult malignancies. Understanding the molecular mechanisms of pathway regulation is therefore of high interest. Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) comprise a group of protein kinases which are emerging modulators of signal transduction, cell proliferation, survival, and cell differentiation...
November 21, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615568/roles-of-the-hedgehog-signaling-pathway-in-epidermal-and-hair-follicle-development-homeostasis-and-cancer
#17
REVIEW
Yoshinori Abe, Nobuyuki Tanaka
The epidermis is the outermost layer of the skin and provides a protective barrier against environmental insults. It is a rapidly-renewing tissue undergoing constant regeneration, maintained by several types of stem cells. The Hedgehog (HH) signaling pathway is one of the fundamental signaling pathways that contributes to epidermal development, homeostasis, and repair, as well as to hair follicle development and follicle bulge stem cell maintenance. The HH pathway interacts with other signal transduction pathways, including those activated by Wnt, bone morphogenetic protein, platelet-derived growth factor, Notch, and ectodysplasin...
November 20, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615567/the-roles-of-the-wnt-antagonists-axin-and-lrp4-during-embryogenesis-of-the-red-flour-beetle-tribolium-castaneum
#18
Romy Prühs, Anke Beermann, Reinhard Schröder
In both vertebrates and invertebrates, the Wnt-signaling pathway is essential for numerous processes in embryogenesis and during adult life. Wnt activity is fine-tuned at various levels by the interplay of a number of Wnt-agonists (Wnt ligands, Frizzled-receptors, Lrp5/6 coreceptors) and Wnt-antagonists (among them Axin, Secreted frizzled and Lrp4) to define anterior-posterior polarity of the early embryo and specify cell fate in organogenesis. So far, the functional analysis of Wnt-pathway components in insects has concentrated on the roles of Wnt-agonists and on the Wnt-antagonist Axin...
October 15, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615566/introduction-drosophila-a-model-system-for-developmental-biology
#19
EDITORIAL
Nicholas S Tolwinski
Drosophila melanogaster, known colloquially as the fruit fly, remains one of the most commonly used model organisms for biomedical science.[...].
September 20, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615565/a-kinase-duet-performance-in-the-asymmetric-division-of-drosophila-neuroblasts
#20
Christopher A Johnston
The ability of progenitor stem cells to divide asymmetrically allows for the production of diverse daughter cell fates.[...].
September 14, 2017: Journal of Developmental Biology
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