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Biomedical Reports

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https://www.readbyqxmd.com/read/30083318/diagnostic-and-prognostic-value-of-circulating-lncrna-h19-in-gastric-cancer
#1
Ebru Esin Yörüker, Metin Keskin, Cemil Burak Kulle, Stefan Holdenrieder, Ugur Gezer
Gastric cancer (GC) is among the most frequent malignant diseases. Despite advances in treatment, the clinical outcome of patients with GC remains poor. The establishment of novel biomarkers is urgently required for early detection, treatment evaluation and prognostic assessment. Non-coding RNAs (ncRNAs) are a key topic of intensive research due to their potential applications in the field of oncology. The long ncRNA H19 has been frequently reported as overexpressed in many cancers including GC. In the present study, the diagnostic and prognostic value of circulating H19 in GC was assessed...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30083317/silica-nanoparticles-of-microrods-enter-lung-epithelial-cells
#2
Thomas Tschernig, Thorben Fischer, Alexander Grissmer, Anja Beckmann, Carola Meier, Peter Lipp, Marc Schneider
A novel type of microparticle has recently been engineered. It consists of amorphous silica nanoparticles and has a corncob-like shape. It has already been demonstrated in vivo that alveolar macrophages in the lung are able to engulf this particulate carrier and that it also functions successfully as a gene delivery system. This subsequently raises the question as to whether epithelial cells may also be possible targets for these microrods. For this purpose, the alveolar epithelial cell line A549 was used presently...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30013780/anti-proliferative-effect-of-ridaifen-b-on-hepatoma-cells
#3
Go Hasegawa, Kotomi Akatsuka, Keita Hiruma, Kayako Suda, Yumiko Yokoe, Akihito Mizusawa, Nozomi Ota, Natsumi Shibata, Kaho Tsuchiya, Moyuru Hayashi, Isamu Shiina, Motoyuki Shimonaka
Ridaifens (RIDs), a novel series of tamoxifen derivatives, exhibit a potent growth-inhibitory effect against numerous tumor cells regardless of the expression of estrogen receptors, and are thus promising candidates as novel anti-tumor drugs. RID-B is a first generation RIDs, and inhibits the proliferation of several tumor cell lines. However, the potentially growth inhibitory effect of RID-B against hepatoma cells, and the detailed mechanism underlying RID-B-mediated tumor cell death remain to be elucidated...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30013779/second-line-triple-therapy-in-failures-with-vonoprazan-based-triple-therapy-for-eradication-of-helicobacter-pylori
#4
Naoyoshi Mori, Yuuki Nishiura, Daisuke Suga, Isao Moritani, Yutaka Yamanaka, Yumi Ooya, Hidekazu Inoue, Koujirou Takase, Masato Hioki, Katsuya Shiraki
Gastric acid inhibition during treatment is important for the eradication of Helicobacter pylori ( H. pylori ) infection. A novel potassium-competitive acid blocker, vonoprazan (VPZ), has been demonstrated to achieve high eradication rates; however, the efficacy of second-line treatment in failures of VPZ-based triple therapy has not been well studied. The aim of the current study was to determine the efficacy of VPZ in a first-line regimen for H. pylori eradication, and the efficacy of a second-line regimen using metronidazole (MTZ) in failures with the first-line regimen...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30013778/mir-124-3p-acts-as-a-potential-marker-and-suppresses-tumor-growth-in-gastric-cancer
#5
Feng Liu, Hongjuan Hu, Jianfu Zhao, Zhiwei Zhang, Xiaohong Ai, Liyun Tang, Liming Xie
miR-124-3p has been implicated in a variety of cancers. The purpose of the present study was to investigate the expression, prognostic roles and functions of miR-124-3p in gastric cancer. Functional studies indicated that ectopic overexpression of miR-124-3p in gastric cancer cells suppressed cell viability and plate colony formation in vitro and tumor growth in vivo. In situ hybridization analysis demonstrated that decreased expression of miR-124-3p was associated with clinical stage and lymph node metastasis, as well as shorter overall survival and disease-free survival rates...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30013777/phenotypic-spectrum-of-slc25a4-mutations
#6
REVIEW
Josef Finsterer, Sinda Zarrouk-Mahjoub
There is no comprehensive overview concerning the phenotypic variability in patients carrying SLC25A4 mutations available. Therefore, the aim of the present review was to summarise and discuss recent findings concerning the clinical presentation and phenotypic heterogeneity of SLC25A4 mutations. The study was conducted by systematically reviewing the literature using the search terms 'mitochondrial', "myopathy', 'nuclear DNA', 'mitochondrial DNA', in combination with 'SLC25A4' or 'AAC1'. The results indicated that the phenotypic heterogeneity in patients carrying a SLC25A4 mutation is broader than so far anticipated...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30013776/conceptual-frameworks-of-synthetic-lethality-in-clear-cell-carcinoma-of-the-ovary
#7
REVIEW
Hiroshi Kobayashi, Naoki Kawahara, Kenji Ogawa, Yuki Yamada, Kana Iwai, Emiko Niiro, Sachiko Morioka
Targeting non-oncogenes may result in the selective death of cancer cells. Clear cell carcinoma of the ovary (CCC) may exhibit resistance against conventional chemotherapy and is associated with poor prognosis. The aim of the present report was to review synthetic lethality-based therapies for CCC. Previous English-language studies were reviewed to accumulate preclinical and clinical data on targeting synthetic lethal partners. Synthetic lethal interactions have a variety of types, involving components of a backup or parallel pathway with overlapping functions, components encoded by paralogous pairs, subunit components that form heteromeric complexes and components that are arranged in a single linear pathway...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30013775/changes-in-gene-expression-as-one-of-the-key-mechanisms-involved-in-radiation-induced-bystander-effect
#8
REVIEW
Mykyta Sokolov, Ronald Neumann
The radiation-induced bystander effect (RIBE) refers to the manifestation of responses by non-targeted/non-hit cells or tissues situated in proximity to cells and tissues directly exposed to ionizing radiation (IR). The RIBE is elicited by agents and factors released by IR-hit cells. The growing body of data suggests that the underlying mechanisms of the RIBE are multifaceted depending both on the biological (characteristics of directly IR-exposed cells, bystander cells, intercellular milieu) and the physical (dose, rate and type of IR, time after exposure) factors/parameters...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29963307/ephrinb2-signalling-modulates-the-neural-differentiation-of-human-dental-pulp-stem-cells
#9
Boon Chin Heng, Ting Gong, Jianguang Xu, Lee Wei Lim, Chengfei Zhang
Dental pulp stem cells (DPSCs) originate from the embryonic neural crest and have neurogenic potential. The present study investigated the roles of the forward and reverse EphrinB2 signalling pathways during DPSC neurogenesis. Treatment of DPSCs with recombinant EphrinB2-Fc protein over 7 days in a neural induction culture resulted in significant downregulation of the following neural markers: βIII-Tubulin, neural cell adhesion molecule (NCAM), nestin, neurogenin 2 (NGN2), neurofilament medium polypeptide and Musashi1...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29963306/microrna-array-analysis-of-the-regulation-of-micrornas-in-rats-exhibiting-hyperplasia-of-mammary-glands
#10
Liyan Gu, Qingxin Xu, Haitao Liu, Jingru Xie, Lide Zhang
Hyperplasia of mammary glands (HMG) is also termed mammary dysplasia. In China, the number of patients suffering from breast hyperplasia is increasing annually. MicroRNAs (miRNAs; length, 19-24 nucleotides), a group of small endogenous non-coding RNAs, post-transcriptionally regulate gene expression via RNA interference and gene silencing pathways. The cause of disease of HMG because remains unclear. Thus, the aim of the present study was to establish comprehensive profile of drug treatments following at different time intervals on rat models of differentially expressed miRNAs, using miRNA microarray data...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29963305/distribution-and-change-of-peroxynitrite-in-the-guinea-pig-cochlea-following-noise-exposure
#11
Wei-Ju Han, Xiao-Rui Shi, Alfred Nuttall
Nitric oxide (NO)-mediated pathology depends on the formation of reactive intermediates, such as the peroxynitrite (ONOO- ). ONOO- can nitrate free tyrosine and tyrosine residues of proteins. Therefore, increases in tyrosine nitration reflect the amount of ONOO- produced by oxidative stress. The distribution of 3-nitrotyrosine (3-NT), an ONOO- marker, in the organ of corti and the cochlear lateral wall tissue from the guinea pig were examined using fluorescence immunohistochemistry. The immunoactivity of 3-NT in the normal guinea pig was compared with animals exposed to 122dBA broadband noise, 4 h/day, for 2 consecutive days...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29963304/six-novel-susceptibility-loci-for-coronary-artery-disease-and-cerebral-infarction-identified-by-longitudinal-exome-wide-association-studies-in-a-japanese-population
#12
Yoshiki Yasukochi, Jun Sakuma, Ichiro Takeuchi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Yoshiji Yamada
Coronary artery disease (CAD) and cerebral infarction (CI) remain major causes of morbidity and mortality in humans. Recent genome-wide association studies have identified various genetic variants associated with these diseases. However, these studies were commonly conducted in a cross-sectional manner. Therefore, the present research performed longitudinal exome-wide association studies for CAD and CI using data on ~244,000 genotyped variants and the clinical data of 6,026 Japanese individuals who had attended annual health checkups for several years (mean followed-up period, 5±3 years)...
August 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930810/efficacy-of-orlistat-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#13
Hu Wang, Li Wang, Yujia Cheng, Zhiqing Xia, Yifeng Liao, Jiang Cao
In the present meta-analysis, the efficacy and safety of orlistat in the treatment of non-alcoholic fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH) were evaluated. PubMed, Embase, the Cochrane Library, Web of Science, and Wan Fang data were searched for controlled trials of orlistat in patients with NAFLD or NASH, published before August 2017. Three randomized controlled trials and four single-arm trials were included. The involved participants with NAFLD or NASH (330 patients) were analyzed for clinical outcomes including alteration in hepatic histological variables and biomarkers of liver function...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930809/induction-of-the-apoptotic-pathway-by-oxidative-stress-in-spontaneous-preterm-birth-single-nucleotide-polymorphisms-maternal-lifestyle-factors-and-health-status
#14
Federica Tarquini, Elena Picchiassi, Giuliana Coata, Michela Centra, Vittorio Bini, Samanta Meniconi, Chiara Antonelli, Irene Giardina, Gian Carlo Di Renzo
The purpose of the present study was to search for associations between spontaneous preterm birth (sPTB), single nucleotide polymorphisms (SNPs) associated with the apoptotic pathway as triggered by oxidative stress, maternal lifestyle and health status. SNP genotyping [rs7560 for c-Jun N-terminal kinase (JNK), rs9517320 for mammalian STE20-like protein kinase 3 (MST3), rs1049216 for caspase 3 (CASP3)] in the placenta and maternal blood of 300 controls with at-term birth and 43 cases of sPTB was performed. No association was identified in genotype frequencies or combinations of foetal/maternal genotypes between single SNPs and sPTB...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930808/effect-of-fermented-vegetable-beverage-containing-pediococcus-pentosaceus-in-patients-with-mild-to-moderate-ulcerative-colitis
#15
Shigeki Bamba, Kenichiro Takahashi, Hirotsugu Imaeda, Atsushi Nishida, Masahiro Kawahara, Osamu Inatomi, Mitsushige Sugimoto, Masaya Sasaki, Akira Andoh
In patients with ulcerative colitis (UC), probiotics are often employed as an adjuvant therapeutic option. In the present study, a fermented vegetable beverage containing Pediococcus pentosaceus strain IDS885 was administered to patients with active UC for 8 weeks. A total of 11 patients with mildly to moderately active UC were randomly assigned into two groups: Group A (n=6), in which the subjects consumed the fermented beverage for 8 weeks immediately following enrollment, and Group B (n=5), in which the subjects were followed up for 8 weeks following enrollment and then consumed the beverage over the ensuring 8 weeks...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930807/mitochondrial-g8292a-and-c8794t-mutations-in-patients-with-niemann-pick-disease-type-c
#16
Abbas Masserrat, Fatemeh Sharifpanah, Leila Akbari, Seyed Hasan Tonekaboni, Parvaneh Karimzadeh, Mahmood Reza Asharafi, Safoura Mazouei, Heinrich Sauer, Massoud Houshmand
Niemann-Pick disease type C (NP-C) is a neurovisceral lipid storage disorder. At the cellular level, the disorder is characterized by accumulation of unesterified cholesterol and glycolipids in the lysosomal/late endosomal system. NP-C is transmitted in an autosomal recessive manner and is caused by mutations in either the NPC1 (95% of families) or NPC2 gene. The estimated disease incidence is 1 in 120,000 live births, but this likely represents an underestimate, as the disease may be under-diagnosed due to its highly heterogeneous presentation...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930806/synovial-fluid-uric-acid-level-aids-diagnosis-of-gout
#17
Binit Vaidya, Manisha Bhochhibhoya, Shweta Nakarmi
Examination of urate crystal in synovial fluid (SF) remains the gold standard for diagnosis of gout, but is not universally available. SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SSR) for diagnosis of gout. A cross-sectional study was conducted at the National Center for Rheumatic Diseases, Nepal. Patients presenting with acute (<1 day) joint pain and/or swelling were included. Aspiration was performed in all patients and fluid was subjected to testing for urate level, pH and cell counts and microscopy...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930805/detection-of-herv-k6-and-herv-k11-transpositions-in-the-human-genome
#18
Buket Cakmak Guner, Elif Karlik, Sevgi Marakli, Nermin Gozukirmizi
Mobile genetic elements classed as transposons comprise an estimated 45% of the human genome, and 8% of these elements are human endogenous retroviruses (HERVs). Endogenous retroviruses are retrotransposons, containing 5' and 3' long terminal repeat sequences and encoding envelope, group-specific antigen and DNA polymerase proteins. The aim of the present study was to analyse genome integration polymorphisms of HERV type K member 6 (HERV-K6) and HERV-K11 by using the retrotransposon based molecular marker technique, inter-retrotransposon amplified polymorphism (IRAP)...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930804/potential-candidate-treatment-agents-for-targeting-of-cholangiocarcinoma-identified-by-gene-expression-profile-analysis
#19
Suthipong Chujan, Tawit Suriyo, Teerapat Ungtrakul, Yotsawat Pomyen, Jutamaad Satayavivad
Cholangiocarcinoma (CCA) remains to be a major health problem in several Asian countries including Thailand. The molecular mechanism of CCA is poorly understood. Early diagnosis is difficult, and at present, no effective therapeutic drug is available. The present study aimed to identify the molecular mechanism of CCA by gene expression profile analysis and to search for current approved drugs which may interact with the upregulated genes in CCA. Gene Expression Omnibus (GEO) was used to analyze the gene expression profiles of CCA patients and normal subjects...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930803/stevens-johnsons-syndrome-or-drug-induced-lupus-a-clinical-dilemma-a-case-report-and-review-of-the-literature
#20
Violeta Claudia Bojinca, Mihai Bojinca, Madalina Gheorghe, Adelina Birceanu, Cristina Ileana Iosif, Serban Mihai Balanescu, Andra Rodica Balanescu
Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]...
July 2018: Biomedical Reports
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