journal
https://read.qxmd.com/read/38398476/caries-experience-before-and-after-covid-19-restrictions-an-observational-study
#21
JOURNAL ARTICLE
Eduardo Guerreiro, João Botelho, Vanessa Machado, Luís Proença, José João Mendes, Ana Cristina Manso
Background: The declaration of COVID-19 as a pandemic by the World Health Organization in 2020 led to the suspension of several clinical practices globally, including dentistry. This study investigates the impact of these restrictions on dental caries experience. Methods: A retrospective cross-sectional study was conducted at Egas Moniz University's dental hospital in the Lisbon Metropolitan Area from June 2019 to June 2021. The study involved 3380 participants who were divided into two cohorts: after and before COVID-19 restrictions...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398475/influence-of-cementation-mode-and-ferrule-design-on-the-fatigue-resistance-of-monolithic-zirconia-endocrowns
#22
JOURNAL ARTICLE
Milan Stoilov, Tobias Boehmer, Lea Stoilov, Helmut Stark, Michael Marder, Norbert Enkling, Dominik Kraus
Background : Classic endocrowns made of dental ceramics are considered a promising alternative to traditional post-endodontic restorations. The use of circular ferrules in endocrowns is a topic of controversial discussion. Therefore, the present study aims to evaluate the effect of ferrule design and cementation mode on the fatigue resistance of zirconia endocrowns. Methods : Eighty human molars were divided into four groups ( n = 20): NFC (no-ferrule, conventional cementation), NFA (no-ferrule, adhesive luting), FC (ferrule, conventional cementation) and FA (ferrule, adhesive luting)...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398474/the-impact-of-mechanical-bowel-preparation-and-oral-antibiotics-in-colorectal-cancer-surgery-mecca-study-a-prospective-randomized-clinical-trial
#23
JOURNAL ARTICLE
Maximos Frountzas, Victoria Michalopoulou, Georgia Georgiou, Despoina Kanata, Maria Matiatou, Despina Kimpizi, Georgia Matthaiou, Spilios Spiliotopoulos, Dimitrios Vouros, Konstantinos G Toutouzas, George E Theodoropoulos
Background: Colorectal cancer surgery has been associated with surgical site infections (SSIs), leading to an increase in postoperative morbidity, length of stay and total cost. The aim of the present randomized study was to investigate the relationship between the preoperative administration of oral antibiotic therapy and SSI rate, as well as other postoperative outcomes in patients undergoing colorectal cancer surgery. Material and Methods: Patients who underwent colorectal cancer surgery in a university surgical department were included in the present study...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398473/diagnostic-value-of-ileal-lesions-found-during-colonoscopy-with-reference-to-endoscopic-indications-and-findings
#24
JOURNAL ARTICLE
Dae Sung Kim, Ji Eun Ryu, Jieun Shin, Hoon Sup Koo, Sanghyuk Lee, Hwanhyi Cho, Jongheon Na, Kyu Chan Huh
The diagnostic value of ileoscopy is not well established, and its routine practice is controversial. We aimed to investigate the diagnostic value of biopsy for macroscopically abnormal lesions in the terminal ileum and to identify the association between endoscopic indications and findings and the presence of significant disease. This retrospective study included 551 patients who underwent biopsy of abnormal lesions in the terminal ileum (TI) during colonoscopy between February 2000 and June 2019. Biopsy results were analyzed in relation to the endoscopic indications and gross findings...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398472/tgf-%C3%AE-1-psmad-2-3-smad-7-and-%C3%AE-catenin-are-augmented-in-the-pulmonary-arteries-from-patients-with-idiopathic-pulmonary-fibrosis-ipf-role-in-driving-endothelial-to-mesenchymal-transition-endmt
#25
JOURNAL ARTICLE
Archana Vijay Gaikwad, Mathew Suji Eapen, Surajit Dey, Prem Bhattarai, Affan Mahmood Shahzad, Collin Chia, Jade Jaffar, Glen Westall, Darren Sutherland, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Wenying Lu, Sukhwinder Singh Sohal
Background: We have previously reported that endothelial-to-mesenchymal transition (EndMT) is an active process in patients with idiopathic pulmonary fibrosis (IPF) contributing to arterial remodelling. Here, we aim to quantify drivers of EndMT in IPF patients compared to normal controls (NCs). Methods: Lung resections from thirteen IPF patients and eleven NCs were immunohistochemically stained for EndMT drivers, including TGF-β1, pSmad-2/3, Smad-7, and β-catenin. Intima, media, and adventitia were analysed for expression of each EndMT driver in pulmonary arteries...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398471/prevalence-of-steatotic-liver-disease-based-on-a-new-nomenclature-in-the-japanese-population-a-health-checkup-based-cross-sectional-study
#26
JOURNAL ARTICLE
Takao Miwa, Satoko Tajirika, Nanako Imamura, Miho Adachi, Ryo Horita, Tatsunori Hanai, Taku Fukao, Masahito Shimizu, Mayumi Yamamoto
This cross-sectional study examined the prevalence and characteristics of steatotic liver disease (SLD) based on a recently introduced nomenclature in the Japanese health checkup population. SLD was evaluated using liver ultrasonography, and participants were categorized into metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol associated steatotic liver disease (MetALD), alcohol-associated/related liver disease (ALD), and cryptogenic SLD groups. The prevalence and characteristics of the SLD subclasses were assessed, and subgroup analyses were conducted for the non-obese (body mass index [BMI] ≤ 25 kg/m2 ) and lean (BMI ≤ 23 kg/m2 ) populations...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398470/linear-iga-bullous-dermatosis-in-korea-using-the-nationwide-health-insurance-database
#27
JOURNAL ARTICLE
Yu Rim Kim, Ji Hyeon Kim, Sang Won Kim, Jae Min Lee, Jacob S Bae
(1) Background: Linear immunoglobulin A bullous dermatosis (LABD) is a rare autoimmune, subepidermal blistering disease, characterized by linear IgA deposits along the epidermal basement membrane. LABD is idiopathic and is associated with medication and systemic autoimmune diseases. (2) Methods: We investigated the demographic characteristics, disease course, causative agents, and associated diseases in Korean patients with LABD. The Korean Health Insurance Review and Assessment Service database was used to obtain data...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398469/new-designs-of-spectacle-lenses-for-the-control-of-myopia-progression-a-scoping-review
#28
REVIEW
Marta Lupon, Carme Nolla, Genis Cardona
Myopia control with new designs of spectacle lenses is a flourishing area of research. The present work reviews the effectiveness of new designs (DIMSs, defocus-incorporated multiple segments; CARE, cylindrical annular refractive element; HALs/SALs, highly/slightly aspherical lenslets; DOT, diffusion optics technology) aiming at slowing myopia progression. A search through the PubMed database was conducted for articles published between 1 January 2003 and 28 February 2023. Publications were included if they documented baseline central refraction (SER) and/or axial length (AL) data, and the change in these parameters, in myopic children wearing new designs of spectacle lenses (treatment group) compared to myopic children using single-vision lenses, SVLs (control group)...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398468/utilization-of-tenting-pole-abutments-for-the-reconstruction-of-severely-resorbed-alveolar-bone-technical-considerations-and-case-series-reports
#29
Dong-Seok Sohn, Albert Lui, Hyunsuk Choi
INTRODUCTION: Although various surgical techniques have been utilized in the reconstruction of severely resorbed alveolar bone, its regeneration is still regarded as a major challenge. Most of the surgical techniques used in advanced ridge augmentation have the disadvantages of prolonging the patient's edentulous healing and increasing the need for surgical revisits because simultaneous implant placement is not allowed. This report presents a new and simplified method for advanced ridge augmentation, which utilizes a vertical tenting device...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398467/exploring-the-therapeutic-potential-of-ganoderma-lucidum-in-cancer
#30
REVIEW
Gabriella Cancemi, Santino Caserta, Sebastiano Gangemi, Giovanni Pioggia, Alessandro Allegra
Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, and α-D-mannans, are the main secondary metabolites of the medicinal fungus Ganoderma lucidum . There is evidence of the effects of ganoderic acid in hematological malignancies, whose mechanisms involve the stimulation of immune response, the macrophage-like differentiation, the activation of MAP-K pathway, an IL3-dependent cytotoxic action, the induction of cytoprotective autophagy, and the induction of apoptosis...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398466/immuno-diagnostic-interest-in-monitoring-cd16-cd56-natural-killer-cells-and-cd19-cd45-b-lymphocytes-in-individuals-newly-diagnosed-with-hiv-in-a-tertiary-care-center
#31
JOURNAL ARTICLE
Jamil Al-Mughales
BACKGROUND/OBJECTIVE: Monitoring multiple cellular markers of immune cells may provide a more accurate evaluation of the immune status of people living with human immunodeficiency virus (PLHIV). This study assessed the value of CD16+CD56+ cells (NK cells) and CD19+ lymphocytes (B cells) phenotyping in indicating viral load, AIDS status, and treatment efficacy. METHOD: A retrospective, laboratory-based study was conducted at the Diagnostic immunology division of a referral tertiary hospital...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398465/perspectives-for-the-use-of-umbilical-cord-blood-in-transplantation-and-beyond-initiatives-for-an-advanced-and-sustainable-public-banking-program-in-greece
#32
JOURNAL ARTICLE
Patra Pateraki, Helen Latsoudis, Anastasia Papadopoulou, Ioanna Gontika, Irene Fragiadaki, Irene Mavroudi, Nikoleta Bizymi, Aristea Batsali, Michail E Klontzas, Angeliki Xagorari, Efstathios Michalopoulos, Damianos Sotiropoulos, Evangelia Yannaki, Catherine Stavropoulos-Giokas, Helen A Papadaki
The umbilical cord blood (UCB) donated in public UCB banks is a source of hematopoietic stem cells (HSC) alternative to bone marrow for allogeneic HSC transplantation (HSCT). However, the high rejection rate of the donated units due to the strict acceptance criteria and the wide application of the haploidentical HSCT have resulted in significant limitation of the use of UCB and difficulties in the economic sustainability of the public UCB banks. There is an ongoing effort within the UCB community to optimize the use of UCB in the field of HSCT and a parallel interest in exploring the use of UCB for applications beyond HSCT i...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398464/impact-of-implant-size-and-position-on-subsidence-degree-after-anterior-cervical-discectomy-and-fusion-radiological-and-clinical-analysis
#33
JOURNAL ARTICLE
Adam Bębenek, Maciej Dominiak, Grzegorz Karpiński, Tomasz Pawełczyk, Bartosz Godlewski
BACKGROUND: Implant subsidence is recognized as a complication of interbody stabilization, although its relevance remains ambiguous, particularly in terms of relating the effect of the position and depth of subsidence on the clinical outcome of the procedure. This study aimed to evaluate how implant positioning and size influence the incidence and degree of subsidence and to examine their implications for clinical outcomes. METHODS: An observational study of 94 patients (157 levels) who underwent ACDF was conducted...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398463/exploring-the-impact-of-hand-dominance-on-laparoscopic-surgical-skills-development-using-network-models
#34
JOURNAL ARTICLE
Saiteja Malisetty, Elham Rastegari, Ka-Chun Siu, Hesham H Ali
BACKGROUND: Laparoscopic surgery demands high precision and skill, necessitating effective training protocols that account for factors such as hand dominance. This study investigates the impact of hand dominance on the acquisition and proficiency of laparoscopic surgical skills, utilizing a novel assessment method that combines Network Models and electromyography (EMG) data. METHODS: Eighteen participants, comprising both medical and non-medical students, engaged in laparoscopic simulation tasks, including peg transfer and wire loop tasks...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398462/a-comparative-analysis-of-liver-injury-markers-in-post-covid-syndrome-among-elderly-patients-a-prospective-study
#35
JOURNAL ARTICLE
Adrian Vasile Bota, Felix Bratosin, Satya Sai Sri Bandi, Iulia Bogdan, David Vladut Razvan, Ana-Olivia Toma, Mirela Florica Indries, Andrei Nicolae Csep, Coralia Cotoraci, Mihaela Prodan, Felicia Marc, Flavia Ignuta, Iosif Marincu
BACKGROUND: In the wake of the global COVID-19 pandemic, understanding its prolonged impact on vulnerable populations has become a critical area of investigation. This study aimed to elucidate the distinctive post-acute sequelae of SARS-CoV-2 infection (PASC) and liver injury in Romania's elderly population, hypothesizing unique demographic, clinical, and healthcare factors influencing the manifestation. METHODS: A longitudinal design was employed, enrolling COVID-19 patients from the Victor Babes Hospital for Infectious Diseases and Pulmonology in Timisoara, Romania...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398461/clinical-radiologic-and-functional-outcomes-following-bone-grafting-for-metacarpal-non-unions-a-systematic-review
#36
REVIEW
Omar El Sewify, Jad Abi-Rafeh, Jack Legler, Shayan Karimi, Aslan Baradaran, Johnny I Efanov
Objectives : Metacarpal non-unions are complex hand defects that can lead to severe hand impairment. Treatment may require the use of artificial or autologous bone grafts. This systematic review aims to describe the outcomes of bone grafting following metacarpal non-union in an attempt to establish an optimal therapeutic protocol for this complication. Methods : A systematic review was conducted in adherence with PRISMA guidelines. Data collection and analysis were performed in duplicate and confirmed by a third investigator...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398460/navigating-the-spectrum-of-two-pediatric-covid-19-complications-multi-system-inflammatory-syndrome-in-children-and-post-acute-sequelae-of-sars-cov-2-infection
#37
REVIEW
Simon Parzen-Johnson, Ben Z Katz
PURPOSE: This review summarizes the current scope of understanding associated with two common post-infectious complications associated with COVID-19 infection: Multi-System Inflammatory Syndrome in Children (MIS-C) and Post-Acute Sequelae of SARS-CoV-2 infection (PASC). It identifies current gaps in the knowledge and issues that may limit the ability to fill these gaps. This review provides a framework to drive continued research. METHODS: A comprehensive review of the current literature was performed, identifying seminal articles describing the emergence of MIS-C and PASC, and works from the literature focused on the clinical implications and pathophysiologic understanding of these disorders...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398459/prospective-study-on-the-correlation-between-cart-and-leptin-gene-expression-obesity-and-reproductive-hormones-in-individuals-undergoing-bariatric-surgery
#38
JOURNAL ARTICLE
Charalampos Voros, Kyriakos Mpananis, Angeliki Papapanagiotou, Abraham Pouliakis, Despoina Mavrogianni, Konstantina Mavriki, Ioannis Gkaniatsos, Christina Karasmani, Ioannis Prokopakis, Menelaos Darlas, Sofia Anysiadou, George Daskalakis, Ekaterini Domali
Obesity, a global health concern affecting 650 million individuals of all ages worldwide, prompts health complications, including fertility issues. This research investigates the impact of bariatric surgery on morbidly obese females under 40, examining the relationship between CART and leptin gene expressions and reproductive hormones. Post-surgery, a significant reduction in BMI (16.03 kg/m2 , n = 29) was observed, accompanied by notable hormonal changes. FSH levels showed a mean difference of 3.18 ± 1...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398458/developing-a-nomogram-for-prioritizing-hysteroscopy-in-endometrial-cancer-diagnosis-a-case-control-study
#39
JOURNAL ARTICLE
Bruna Bottura, Raphael Federicci Haddad, Vanessa Alvarenga-Bezerra, Vinicius Campos, Luiza Perez, Carolina Resende, Fernanda de Almeida Asencio, Adolfo Wenjaw Liao, Mariano Tamura Vieira Gomes, Eduardo Zlotnik, Renato Moretti-Marques
(1) Background: The pandemic led to significant healthcare disruptions, resulting in postponed surgeries and extended waiting times for non-urgent treatments, including hysteroscopies essential for diagnosing endometrial cancer. This study aims to formulate a risk stratification model to enhance the prioritization of hysteroscopy procedures in Brazil; (2) Methods: A case-control study was conducted at Vila Santa Catarina Hospital in São Paulo, analyzing the medical records of 2103 women who underwent hysteroscopy between March 2019 and March 2022...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398457/stage-5-chronic-kidney-disease-epidemiological-analysis-in-a-northeastern-district-of-italy-focusing-on-access-to-nephrological-care
#40
JOURNAL ARTICLE
Francesca K Martino, Giulia Fanton, Fiammetta Zanetti, Mariarosa Carta, Federico Nalesso, Giacomo Novara
BACKGROUND: We conducted a retrospective epidemiological study about the prevalence of stage 5 chronic kidney disease (CKD) in a high-income district, comparing some demographic characteristics and outcomes of those patients who had nephrological consultations and those who had not. RESULTS: In a district of 400,000 adult subjects in 2020, 925 patients had an estimated glomerular filtration rate (eGFR) under 15 mL/min and CKD. In the same period, 747 (80.4%) patients were assessed by nephrologists, while 178 (19...
February 18, 2024: Journal of Clinical Medicine
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