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Avicenna Journal of Phytomedicine

Mohamed Eddouks, Ahmed Lemhadri, Morad Hebi, Ahmed El Hidani, Naoufel Ali Zeggwagh, Bachir El Bouhali, Lhoussaine Hajji, Remy Burcelin
OBJECTIVE: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice. MATERIALS AND METHODS: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-(3)H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity...
March 2017: Avicenna Journal of Phytomedicine
Alireza Golshan, Parichehr Hayatdavoudi, Mousa Al-Reza Hadjzadeh, Abolfazl Khajavi Rad, Nema Mohamadian Roshan, Abbasali Abbasnezhad, Seyed Mojtaba Mousavi, Roghayeh Pakdel, Batool Zarei, Azita Aghaee
OBJECTIVES: The antioxidant capacity impairs in kidney and urinary bladder of animals with stone disease. Herbal medicine can improve the antioxidant condition of renal tissue. Cynodon dactylon (C. dactylon) is a medicinal plant with antioxidative and diuretic properties and different preparations of this plant have shown promising effects in stone disease. Assessment of the whole plant decoction to prevent kidney stone disease as well as its antioxidant effects was the aim of this paper...
March 2017: Avicenna Journal of Phytomedicine
Akram Ahangarpour, Hamid Heidari, Ali Akbar Oroojan, Farhang Mirzavandi, Khalil Nasr Esfehani, Zeinab Dehghan Mohammadi
OBJECTIVE: Arctium lappa (burdock), (A. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties of A. lappa root extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice. MATERIALS AND METHODS: In this investigation, 70 adult male NMRI mice (30-35g) randomly divided into 7 groups (n=10) as follow: 1-control, 2-type 2 diabetic mice, 3-diabetic mice that received glibenclamide (0...
March 2017: Avicenna Journal of Phytomedicine
Maryam Varasteh-Kojourian, Parvaneh Abrishamchi, Maryam M Matin, Javad Asili, Hamid Ejtehadi, Fatemeh Khosravitabar
OBJECTIVE: Achillea is a traditional medicinal herb which contains different phenol and flavonoid compounds that are responsible for Achillea pharmacological effects. We aimed to determine phenol and flavonoid contents, besides antioxidant activities of different extracts from Achillea eriophoraa (A. eriophora) DC. and Achillea biebersteinii (A. biebersteinii) Afan. (endemic species in Iran) and to investigate their effects on human cells. MATERIALS AND METHODS: Achillea extracts, were prepared by maceration and shaking methods, from different parts (aerial parts, stem, leaves and inflorescence) of two species using methanol and ethanol as solvents...
March 2017: Avicenna Journal of Phytomedicine
Samaneh Rahamooz Haghighi, Malek Hossein Asadi, Hassan Akrami, Amin Baghizadeh
OBJECTIVE: Acorus calamus (A. calamus) has been used as a medicinal plant in Asia for its effects on digestive system for the last 2000 years. To investigate the anti-cancer activity of rhizome of A. calamus, the ethanolic and methanolic extracts and essential oil of the rhizome were prepared and their effects were assessed on human gastric cancer cell line (AGS). MATERIALS AND METHODS: The viability of cells which were treated with the extracts and the essential oil was assessed by MTT assay...
March 2017: Avicenna Journal of Phytomedicine
Azar Hosseini, Shima Saeidi Javadi, Azar Fani-Pakdel, Seyed Hadi Mousavi
OBJECTIVE: Cervical cancer is the second most common cause of death from cancer in women throughout the world. The aim of this study was to evaluate the cytotoxic activity of Kelussia odoratissima (K. odoratissima) extract associated with radiotherapy in cervical cancer cells (HeLa cell line). MATERIALS AND METHODS: Different concentration of the extract (25-500µg/ml) was tested in HeLa cell lines. Cell cytotoxicity of the extract and the effects of the extract on radiation (2Gy/min)-induced damages were assessed by MTT assay...
March 2017: Avicenna Journal of Phytomedicine
Mansoureh Masoudi, Mahmoud Rafieian Kopaei, Sepideh Miraj
OBJECTIVE: Due to the high incidence of bacterial vaginosis (BV) and its resistance to chemical medications and considering the anti-bacterial and anti-fungal effects of Myrtus communis, the present study aimed to compare the therapeutic effects of the vaginal gel of M. communis 2% (in metronidazole base) with metronidazole vaginal gel 0.75% alone on BV. MATERIALS AND METHODS: This research was a randomized controlled clinical trial conducted on 80 women of 18-40 years old with BV...
March 2017: Avicenna Journal of Phytomedicine
Mojtaba Pourzaki, Mansour Homayoun, Saeed Sadeghi, Masoumeh Seghatoleslam, Mahmoud Hosseini, Alireza Ebrahimzadeh Bideskan
OBJECTIVE: Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure. MATERIALS AND METHODS: Forty male rats were divided into five main groups and treated by (1) saline, (2) PTZ: 100 mg/kg PTZ (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract of C...
March 2017: Avicenna Journal of Phytomedicine
Fatemeh Atarzadeh, Mohammad Kamalinejad, Ladan Dastgheib, Gholamreza Amin, Amir Mohammad Jaladat, Majid Nimrouzi
OBJECTIVE: Pemphigus is a rare autoimmune disease that may be fatal without proper medical intervention. It is a blistering disease that involves both the skin and mucus membranes, in which the most important causes of death comprise superimposed opportunistic infections and complications of long-term high-dose corticosteroid therapy or prolonged consumption of immune suppressant drugs. Skin lesions are the most important sources of infection, and any local treatment decreasing the healing time of lesions and reducing the total dosage of drugs is favorable...
March 2017: Avicenna Journal of Phytomedicine
Jatuporn Noosud, Narissara Lailerd, Autchara Kayan, Chaiwat Boonkaewwan
OBJECTIVE: Stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity. The aim of the present study was to examine in vitro and in vivo effects of stevioside on rats plasma levels of tumor necrosis factor- α (TNF-α), interleukin-1β (IL-1β), TNF-α and IL-1β release from lipopolysaccharide(LPS)-stimulated rat peripheral blood mononuclear cells (PBMCs). MATERIALS AND METHODS: Male wistar rats weighing between 170-220 g were given stevioside (0, 500 and 1000 mg/kg BW/day) for 6 weeks...
March 2017: Avicenna Journal of Phytomedicine
Reza Afshari
No abstract text is available yet for this article.
March 2017: Avicenna Journal of Phytomedicine
Laura Inocencio Leite, Gerlânia de Oliveira Leite, Bruno Anderson Fernandes Silva, Severino Denício Gonçalves Sousa, Thales Silva Coutinho, Renata Souza Sampaio, Irwin Menezes, José Galberto Martins Costa, Adriana Rolim Campos
OBJECTIVE: Vanillosmopsis arborea Baker (Asteraceae) has high economic value from Chapada to Araripe and its bark essential oil is a potential source of alpha-bisabolol. The present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil of V. arborea Baker (EOVA) in mice. MATERIALS AND METHODS: The antinociceptive activity was assessed using the capsaicin, glutamate, hot plate and cold allodynia tests. The antipuritic effects were also verified based on histamine-induced scratching behavior...
January 2017: Avicenna Journal of Phytomedicine
Daniel Lotanna Ajaghaku, Okechukwu Obasi, Blessing Ogechukwu Umeokoli, Peter Ogbuatu, Chukwuemeka Sylvester Nworu, Emmanuel Emeka Ilodigwe, Festus Basden Chiedu Okoye
OBJECTIVE: Alchornea floribunda leaves are widely used in ethnomedicine for the management of immuno-inflammatory disorders. We investigated the in vivo and in vitro antioxidant activity of the leaf extract, fractions and isolated compounds of A. floribunda. MATERIALS AND METHODS: The ethyl acetate fraction of the methanol leaf extract was subjected to several chromatographic separations to isolate compounds 1-4. The structures of the isolated compounds were elucidated by a combination of 1D and 2D NMR and mass spectrometry...
January 2017: Avicenna Journal of Phytomedicine
Niloofar Kahkeshani, Milad Gharedaghi, Abbas Hadjiakhoondi, Mohammad Sharifzadeh, Mahnaz Khanavi
OBJECTIVE: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum. MATERIALS AND METHODS: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice...
January 2017: Avicenna Journal of Phytomedicine
Solmaz Pourgonabadi, Mohammad Sadegh Amiri, Seyed Hadi Mousavi
OBJECTIVE: Bryonia aspera (Stev. ex Ledeb) is a plant that grows in northeast of Iran. In the present study, cytotoxic and apoptogenic properties of B. aspera root extract was determined against HN-5(head and neck squamous cell carcinoma) and Hela (cervix adenocarcinoma) cell lines. MATERIALS AND METHODS: HN-5 and Hela cell lines were cultured in DMEM medium and incubated with different concentrations of B. aspera root extract. Cell viability was quantitated by MTT assay and the optical absorbance was measured at 570 nm (620 nm as the reference) by an ELISA reader, in each experiment...
January 2017: Avicenna Journal of Phytomedicine
Abdollah Jafarzadeh, Reyhane Ahangar-Parvin, Maryam Nemat, Zahra Taghipour, Ali Shamsizadeh, Fatemeh Ayoobi, Zuhair Mohammad Hassan
OBJECTIVE: The main function of IL-12 is differentiation of naive T cells intoTh1 cells and TGF-β is a powerful immunoregulatory cytokine. The immunomodulatory and anti-inflammatory properties of ginger have also been reported in some studies. The aim of this study was to evaluate the effects of ginger extract on the expression of IL-12 and TGF-β in a model of experimental autoimmune encephalomyelitis (EAE). MATERIALS AND METHODS: EAE was induced in C57BL/6 mice by immunization with myelin oligodendroglial glycoprotein emulsified in complete Freund's adjuvant...
January 2017: Avicenna Journal of Phytomedicine
Mehdi Bihamta, Azar Hosseini, Ahmad Ghorbani, Mohammad Taher Boroushaki
OBJECTIVE: It has been well documented that oxidative stress is involved in the pathogenesis of cardiac diseases. Previous studies have shown that pomegranate seed oil (PSO) has antioxidant properties. This study was designed to investigate probable protective effects of PSO against hydrogen peroxide (H2O2)-induced damage in H9c2 cardiomyocytes. MATERIALS AND METHODS: The cells were pretreated 24 hr with PSO 1 hr before exposure to 200 µM H2O2. Cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay...
January 2017: Avicenna Journal of Phytomedicine
Waseem Rizvi, Mohammad Fayazuddin, Ompal Singh, Shariq Naeem Syed, Shagufta Moin, Kafil Akhtar, Anil Kumar
OBJECTIVE: In this study, we evaluated anti-inflammatory activity of leaves of Fumaria parviflora (F. parviflora) and underlying mechanisms by using in vivo models of inflammation. MATERIAL AND METHODS: Albino Wistar rats of either sex weighing 150 - 200 g were used. Soxhlet ethanol and aqueous extracts of leaves of F. parviflora (EFP and AFP) were prepared. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method...
January 2017: Avicenna Journal of Phytomedicine
Jude Efiom Okokon, Joseph Oyepata Simeon, Emem Ekpo Umoh
OBJECTIVE: Homalium letestui Pellegr (Flacourtiaceae) has been traditionally used by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases and Yorubas of western Nigeria as an antidote. This study evaluates the hepatoprotective properties of the ethanol extract of the plant stem. MATERIALS AND METHODS: The hepatoprotective effect of the extract of the stem of the plant (200-600 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver...
January 2017: Avicenna Journal of Phytomedicine
Abbas Meamarbashi
OBJECTIVE: Unaccustomed and intense eccentric exercise is a common cause of delayed-onset muscle soreness (DOMS). There are multiple remedies for the treatment of DOMS, but its clinical and laboratory pieces of evidence are scarce. Currently, the treatments proposed for DOMS are numerous and include pharmaceuticals, herbal remedies, stretching, massage, nutritional supplements, and other alternatives. To find a holistic treatment with effective pain relief and minimum side effects, complementary and alternative medicine, including herbal therapies, plays a main role...
January 2017: Avicenna Journal of Phytomedicine
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