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Avicenna Journal of Phytomedicine

Nazanin Entezari Heravi, Sara Hosseinian, Zohreh Naji Ebrahimi Yazd, Mohammad Naser Shafei, Alireza Ebrahimzadeh Bideskan, Samira Shahraki, Zahra Samadi Noshahr, Fatemeh Motejadded, Farimah Beheshti, Reza Mohebbati, Soghra Parhizgar, Abolfazl Khajavi Rad
Objective: The aim of the present study was to evaluate the possible protective effect of Plantago major ( P. major ) extract against doxorubicin (DXR)-induced renal inflammation in rats. Materials and Methods: 80 male albino rats were randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXR , and Ext1200+DXR. Duration of the study was 35 days and DXR was intravenously injected on the 7th day of the experiment...
March 2018: Avicenna Journal of Phytomedicine
Mahdieh Zaman Emamiyan, Gholamhassan Vaezi, Maryam Tehranipour, Khdije Shahrohkabadi, Abdolhossein Shiravi
Objective: Urolithiasis remains a global problem. Despite the availability of numerous methods, no definite therapeutic agent has been yet introduced for the prevention or treatment of kidney stones. In this study, we evaluated the possible preventive effects of aqueous extract of Cichorium intybus L. (chicory) flowers on ethylene glycol-induced renal calculi in rats. Materials and Methods: A total of 24 Wistar rats were randomly divided into four groups and were treated for 30 days...
March 2018: Avicenna Journal of Phytomedicine
Hadi Khodadadi, Roghayeh Pakdel, Majid Khazaei, Said Niazmand, Kowsar Bavarsad, Mousa Al-Reza Hadjzadeh
Objective: The present study was performed to evaluate the effects of hydro-alcoholic extract of Portulaca oleracea ( P. oleracea ) seeds and Vitamin C on biochemical and hemodynamic parameters in cardiac tissue of rats with subclinical hyperthyroidism. Materials and Methods: Forty eight male rats were divided into six groups of 8 and treated for 4 weeks. T4 group received daily injection of levothyroxine sodium (20 μg/kg) and control group was given daily injection of saline...
March 2018: Avicenna Journal of Phytomedicine
Arshad Ghaffari-Nasab, Fariba Mirzaie Bavil, Rafigheh Ghiasi, Saeed Sadigh-Eteghad, Mohammad Reza Alipour
Objective: Diabetes is associated with vascular complications and impaired angiogenesis. Since angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD™ on miR-503 and CDC25 expression level which are altered in impaired angiogenesis were investigated in heart tissue of diabetic rats. Materials and Methods: Forty male Wistar rats (200-250 g) were randomly classified into 4 groups: control (C), IMOD™ (I), diabetes (D), and diabetes+IMOD™ (D+I)...
March 2018: Avicenna Journal of Phytomedicine
Reza Mohebbati, Kosar Bavarsad, Maryam Rahimi, Hasan Rakhshandeh, Abolfazl Khajavi Rad, Mohammad Naser Shafei
Objective: Ziziphus jujuba stimulates the release of nitric oxide (NO). Because NO is involved in cardiovascular regulations, in this study the effects of hydroalcoholic extract of Z. jujuba on cardiovascular responses in acute NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats were evaluated. Materials and Methods: Rats were divided into 6 group (n=6): 1) saline, 2) L-NAME received (10mg/kg) intravenously, 3) sodium nitroprusside (SNP) (50µg/kg)+L-NAME group received SNP before L-NAME and 4-6) three groups of Z...
March 2018: Avicenna Journal of Phytomedicine
Mohaddeseh Abouhosseini Tabari, Mohammad Reza Youssefi
Objective: Pelargonium roseum Willd. (Geraniaceae) is widely grown as an ornamental plant due to its strong pleasant rose-like odor. The present study evaluates the antitrichomonal effect of P. roseum essential oil (EO) against Trichomonas gallinae both in vitro and in vivo and compares it to that of metronidazole (MTZ) as a standard antitrichomonal drug. Materials and Methods: In vitro assays were accomplished in multi-well plates containing MTZ and EO at final concentrations of 2...
March 2018: Avicenna Journal of Phytomedicine
Badiaa Lyoussi, Khadija Cherkaoui Tangi, Nicole Morel, Mohamed Haddad, Joelle Quetin-Leclercq
Objective: The present investigation was carried out to evaluate the safety of an aqueous extract of the seeds of Calycotome villosa (Poiret) Link (subsp. intermedia) by determining its cytotoxicity and potential toxicity after acute and sub-chronic administration in rodents. Materials and Methods: Cytotoxic activity was tested in cancer and non-cancer cell lines HeLa, Mel-5, HL-60 and 3T3. Acute toxicity tests were carried out in mice by a single oral administration of Calycotome seed-extract (0 - 12 g/kg) as well as intraperitoneal doses of 0 - 5 g/kg...
March 2018: Avicenna Journal of Phytomedicine
Seyed Mostafa Razavi, Mohammad Asadpour, Seyed Hossein Malekpour, Arash Jafari
Objective: The methanolic extracts of Nigella sativa L. seeds (MENS) and Berberis vulgaris L.(MEBV) were investigated for treatment of Haemoproteus columbae- infected pigeons ( Columba livia domestica ). Materials and Methods: One hundred twenty naturally-infected pigeons were randomly divided into four groups of thirty each. Two groups were treated separately with the extracts, while the positive and negative control groups were given buparvaquone ( Butalex ®) and distilled water, respectively...
March 2018: Avicenna Journal of Phytomedicine
Nahid Maleki-Saghooni, Fatemeh Zahra Karimi, Zahra Behboodi Moghadam, Khadigeh Mirzaii Najmabadi
Objective: Premenstrual syndrome (PMS) is one of the most common problems among women of reproductive age. The popularity of complementary/alternative therapies has grown in recent years, and these treatments have been more commonly used by women (48.9%) than men (37.8%). The aim of this systematic review was to assess effectiveness and safety of Iranian herbal medicines for treatment of premenstrual syndrome. Methods: PubMed, Scopus, Cochrane, and Google Scholar were searched along with SID, Magiran and Irandoc up to Dec 2017...
March 2018: Avicenna Journal of Phytomedicine
Tarequl Islam, Md Saddam Hussain, Mohammad Nurul Amin, Ashraful Mahmud Tuhin
Objectives: Swas Kas Chintamani Ras (SKC) is an ayurvedic preparation indicated for respiratory diseases. Our study was aimed to determine the psychopharmacological and neurosafety profile of SKC. Materials and Methods: Psychopharmacological effects and neurosafety profile of this drug were determined by nine complementary test methods namely, open field, locomotor activity, hole cross, hole board test, elevated plus maze, staircase, forced swimming test, and rotarod test...
January 2018: Avicenna Journal of Phytomedicine
Ademola Clement Famurewa, Fidelis Ebele Ejezie
Objective: Literature has confirmed the pathogenic role of cadmium (Cd) and its exposure in the induction of dyslipidemia implicated in the development and increasing incidence of cardiovascular diseases. The current study explored whether polyphenolics isolated from virgin coconut oil (VCO) prevent Cd-induced dyslipidemia and investigate the underlying mechanism of action, in rats. Materials and Methods: Rats were pretreated with VCO polyphenols (10, 20 and 50 mg/kg body weight; orally) 2 weeks prior to concurrent Cd administration (5 mg/kg) for 5 weeks...
January 2018: Avicenna Journal of Phytomedicine
Vahid Zarezade, Jalal Moludi, Mostafa Mostafazadeh, Mohammad Mohammadi, Ali Veisi
Objective: The present study was conducted to investigate the antioxidant and hepatoprotective activity of the hydro-alcoholic extract of aerial parts of Artemisiadracunculus (HAAD) against CCl4-induced hepatotoxicity in rats. Materials and Methods: The antioxidant activity was evaluated by reducing power, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 20-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Rats were pre-treated with either 50, 100, and 200 mg/kg of HAAD or silymarin (100 mg/kg; served as the positive control group) for 15 days and they received a single dose of CCl4 on the last day...
January 2018: Avicenna Journal of Phytomedicine
Gholamali Jelodar, Zahra Javid, Ali Sahraian, Sina Jelodar
Objectives: A correlation between hyperhomocysteinemia, and depression has been reported. Saffron (Crocus sativus) is recommended for treatment of depression; hence, in this study the effect of co-administration of saffron and fluoxetine on plasma homocysteine and depression was evaluated. Material and methods: This was a 4-week randomized and double-blind clinical trial which was conducted from March 2013 to February 2014. In this trial, 40 male and females (20-55 years old) diagnosed with severe depression were selected and following filing the Beck form, were randomly divided into two groups...
January 2018: Avicenna Journal of Phytomedicine
Seyedeh Faezeh Taghizadeh, Gholamhossein Davarynejad, Javad Asili, Seyed Hossein Nemati, Gholamreza Karimi
Objective: In this study, the levels and antioxidant activities of some secondary metabolites isolated from five pistachio (Pistacia vera) cultivars collected from four different geographical regions of Iran, were studied. Materials and Methods: Total phenolic compounds levels were determined by Folin-Ciocalteu method. Total flavonoid content was determined as AlCl3 complex and expressed as mg of quercetin equivalents (QE)/g dry extract and total proantocyanidins content was expressed as mg of catechin equivalents (CA)/g dry extract...
January 2018: Avicenna Journal of Phytomedicine
Majid Hajifaraji, Mohammad Matlabi, Farihe Ahmadzadeh-Sani, Yadollah Mehrabi, Mohammad Salem Rezaee, Homa Hajimehdipour, Abbas Hasanzadeh, Katayoun Roghani
Objective: Dyslipidemia has been considered as a major risk factor for coronary heart disease. Alternative medicine has a significant role in treatment of dyslipidemia. There are controversial findings regarding the effects of sour tea on dyslipidemia. The aim of this study was to evaluate the impact of aqueous extract of dried calyx of sour tea on polygenic dyslipidemia. Materials and Methods: This clinical trial was done on 43 adults (30-60 years old) with polygenic dyslipidemia that were randomly assigned to the intervention and control groups...
January 2018: Avicenna Journal of Phytomedicine
Elaheh Mohammadi, Soghra Mehri, Hasan Badie Bostan, Hossein Hosseinzadeh
Objective: Aging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of the active components of saffron showed strong antioxidant effects. In the present study, anti-aging property of crocin was investigated in mice. Materials and Methods: The model of aging was induced using administration of d-galactose (500 mg/kg, s...
January 2018: Avicenna Journal of Phytomedicine
Majid Nimrouzi, Mohammad Mehdi Zarshenas
Objective: Anorexia and impaired appetite (Dysorexia) are common symptoms with varying causes, and often need no serious medical intervention. Anorexia nervosa (AN) is a chronic psychiatric disease with a high mortality rate. In Traditional Persian Medicine (TPM), anorexia is a condition in which anorexic patients lose appetite due to dystemperament. This review aims to discuss the common points of traditional and conventional approaches rather than introducing Persian medical recommendations suitable for nowadays use...
January 2018: Avicenna Journal of Phytomedicine
Narges Amel Zabihi, Maryam Mahmoudabady, Mohammad Soukhtanloo, Parichehr Hayatdavoudi, Farimah Beheshti, Saeed Niazmand
Objective: Oxidative stress plays a critical role in the development of hypercholesterolemia-induced complications. This study evaluated the effects of aspirin and Salix alba hydroethanolic extract on oxidative stress in the heart and kidney of hypercholesterolemic rabbits. Materials and Methods: The antioxidant activity, as well as total phenolic and salicin content of S. alba (Sa) extract were assessed by DPPH radical scavenging activity, Folin-Ciocalteu and HPLC methods, respectively...
January 2018: Avicenna Journal of Phytomedicine
Maryam Azimi, Mohammad Javad Zahedi, Mitra Mehrabani, Haleh Tajadini, Farzaneh Zolala, Mohammad Reza Baneshi, Rasool Choopani, Fariba Sharififar, Ali Asadipour, Mohammad Mahdi Hayatbakhsh, Bijan Ahmadi
Objectives: This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD). Material and Methods: In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole...
November 2017: Avicenna Journal of Phytomedicine
Firouzeh Gholampour, Fatemeh Behzadi Ghiasabadi, Seyed Mohammad Owji, Jaafar Vatanparast
Objective: Iron overload in the body is related with toxic effects and threatens the health. The aim of this study was to evaluate the protective role of hydroalcoholic extract of ginger ( Zingiber officinale ) against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats. Materials and Methods: The rats were divided into four groups (n=7): Sham, Sham + G.E (ginger extract, 400 mg/kg/day for 14 days), FS (ferrous sulfate, 30 mg/kg/day for 14 days), FS+G...
November 2017: Avicenna Journal of Phytomedicine
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