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Avicenna Journal of Phytomedicine

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https://www.readbyqxmd.com/read/28884087/curcumin-attenuates-harmful-effects-of-arsenic-on-neural-stem-progenitor-cells
#1
Ali Jahanbazi Jahan-Abad, Parastoo Morteza-Zadeh, Sajad Sahab Negah, Ali Gorji
OBJECTIVE: Arsenic, an environmental pollutant, decreases neuronal migration as well as cellular maturation and inhibits the proliferation of neural progenitor cells. Curcumin has been described as an antioxidant and neuroprotective agent with strong therapeutic potential in some neurological disorders. Human adipose-derived stem cells (hADSCs), a source of multipotent stem cells, can self-renew and differentiate into neural cells. The aim of the present study was to investigate the preventive effect of curcumin against arsenic toxic effects on the viability, telomerase activity, and apoptosis of neural stem/progenitor cells (NSPCs) derived from hADSCs...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884086/anti-nociceptive-and-anti-inflammatory-effects-of-the-methanolic-extract-of-opuntia-humifusa-stem
#2
Bhesh Raj Sharma, Chul Min Park, Jong Won Choi, Dong Young Rhyu
OBJECTIVE: Opuntia humifusa (O. humifusa) Raf. has been used for the prevention and treatment of rheumatoid arthritis, inflammation, and cancer. Our study was designed to unveil the anti-nociceptive and anti-inflammatory effects of the methanolic extract of O. humifusa Raf stem (OHS). MATERIALS AND METHODS: The anti-nociceptive effect was measured by hot plate, acetic acid-induced writhing, and tail flick assays in mice and rats. Moreover, the anti-inflammatory effect was measured by vascular permeability and carrageenan and serotonin-induced paw edema tests in rats...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884085/anti-anxiety-and-hypnotic-effects-of-ethanolic-and-aqueous-extracts-of-lippia-citriodora-leaves-and-verbascoside-in-mice
#3
Bibi Marjan Razavi, Naser Zargarani, Hossein Hosseinzadeh
OBJECTIVES: The extract of Lippia citriodora and its main component, verbascoside, are known for their hypnotic effects in traditional medicine. In this study, the anxiolytic and hypnotic effects of L. citriodora leave extracts and verbascoside were evaluated in mice. MATERIALS AND METHODS: Animals were divided into 11 groups of six mice each. Group I received normal saline, Group II received Diazepam (2 mg/kg) as positive control, Groups III, IV and V received L...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884084/crocin-prevents-acute-angiotensin-ii-induced-hypertension-in-anesthetized-rats
#4
Mohammad Naser Shafei, Abdolali Faramarzi, Abolfazl Khajavi Rad, Akbar Anaeigoudari
OBJECTIVE: Angiotensin II (Ang II), the main product of renin-angiotensin system (RAS) has a well-known role in cardiovascular regulation. Over-production of Ang II is one of the important underlying mechanisms of hypertension. In this study, the effect of crocin on cardiovascular responses in rats with acute hypertension induced by Ang II was evaluated. MATERIALS AND METHODS: Rats were divided into six groups (n = 6): 1) Control: rats that received saline, 2) Ang II: rats that received Ang II (300 ng/kg) infused in two min, 3) Losartan (Los) + Ang II : rats that received Los (10 mg/kg, i...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884083/hydro-alcoholic-extract-of-matricaria-recutita-exhibited-dual-anti-spasmodic-effect-via-modulation-of-ca-2-channels-no-and-pka2-kinase-pathway-in-rabbit-jejunum
#5
Hamidreza Yazdi, Akhtar Seifi, Shima Changizi, Vahid Khori, Fatemeh Hossini, Ali Davarian, Yahya Jand, Ayesheh Enayati, Masumeh Mazandarani, Fateme Nanvabashi
OBJECTIVE: Several studies have shown the antispasmodic activity of Matricariarecutita without detailing the underlying mechanism(s). The present study was designed to determine whether the antispasmodic mechanisms of M. recutita extract mediated via histaminergic/cholinergic receptors, Ca(2+)channels, activation of PKA2 and NO release in isolated rabbit jejunum. MATERIALS AND METHODS: The concentration- dependent (3 × 10(-3)-1.3 × 10(-2) mg/ml) antispasmodic effect of the hydro-alcoholic extract of M...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884082/effects-of-pomegranate-seed-oil-on-oxidant-antioxidant-balance-in-heart-and-kidney-homogenates-and-mitochondria-of-diabetic-rats-and-high-glucose-treated-h9c2-cell-line
#6
Hamid Mollazadeh, Mohammad Taher Boroushaki, Mohammad Soukhtanloo, Amir Reza Afshari, Mohammad Mahdi Vahedi
OBJECTIVE: Oxidative stress is a major cause of diabetes complications. The present study aimed to investigate the beneficial effects of Pomegranate Seed Oil (PSO) on diabetes-induced changes in oxidant/antioxidant balance of the kidney, heart and mitochondria from rats and H9c2 cell line. MATERIALS AND METHODS: In these in vivo and in vitro studies, male rats were divided into four groups (twelve each): group 1 served as control, group 2-4 received a single dose of streptozotocin (60 mg/kg, i...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884081/the-effect-of-ginger-herbal-spray-on-reducing-xerostomia-in-patients-with-type-ii-diabetes
#7
Homeira Mardani, Alireza Ghannadi, Bahareh Rashnavadi, Razieh Kamali
OBJECTIVE: The aim of the present study is to evaluate the effect of ginger herbal spray on reducing dry mouth in patients with Type II diabetes. MATERIALS AND METHODS: This clinical trial was conducted on 20 patients with Type II diabetes suffering from dry mouth. The control individual for each patient was the same patient himself/herself. Each patient filled out his/her questionnaire at three different times, (before treatment, after treatment with placebo, and after taking the drug)...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884080/antibacterial-antioxidant-and-cell-proliferative-properties-of-coccinia-grandis-fruits
#8
Prashant Sakharkar, Balwantsinh Chauhan
OBJECTIVE: Little knowledge is available on the antimicrobial and antioxidant properties of Coccina grandis fruits and no study has reported on its cell proliferative property. The aim of this study was to examine the antimicrobial, antioxidant and cell proliferative property of fruits of C. grandis. MATERIALS AND METHODS: Fruits of C. grandis were extracted using water; ethanol and acetone by cold and hot Soxhlet extraction. The antibacterial activities of the extracts were tested against Staphylococcusaureus,Enterococcusfaecalis,Escherichiacoli and Pseudomonasaeruginosa using the modified Kirby-Bauer diffusion method and compared against erythromycin...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884079/podophyllotoxin-a-novel-potential-natural-anticancer-agent
#9
REVIEW
Hamidreza Ardalani, Amir Avan, Majid Ghayour-Mobarhan
OBJECTIVE: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. MATERIALS AND METHODS: Google scholar, PubMed and Scopus were searched for literatures which have studied identification, characterization, fermentation and therapeutic effects of PTOX and published in English language until end of 2016...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748174/antiplasmodial-activity-and-cytotoxicity-of-ethanol-extract-of-zea-mays-root
#10
Jude Efiom Okokon, Bassey Sunday Antia, Bala Adamu Azare, Patience Jude Okokon
OBJECTIVE: Zea mays root decoction that has been traditionally used for the treatment of malaria by various tribes in Nigeria, was evaluated for antimalarial potential against malaria parasites using in vivo and in vitro models. MATERIALS AND METHODS: The root extract of Zea mays was investigated for antimalarial activity against Plasmodium berghei in mice using rodent malaria models; suppressive, prophylactic and curative tests and in vitro antiplasmodial activity against chloroquine-sensitive (Pf 3D7) and resistant (Pf INDO) strains of Plasmodium falciparum using SYBR green assay method...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748173/stereological-investigation-of-the-effect-of-elaeagnus-angustifolia-fruit-hydroalcoholic-extract-on-osteoporosis-in-ovariectomized-rats
#11
Mohmmad Hossein Dabbaghmanesh, Ali Noorafshan, Pedram Talezadeh, Nader Tanideh, Farhad Koohpeyma, Aida Iraji, Marzieh Bakhshayeshkaram, Nima Montazeri-Najafabady
OBJECTIVE: Postmenopausal osteoporosis is characterized by increased fracture risk. However, each approved treatment has specific side effects. Therefore, foods with plant origins have increasingly attracted attention as an alternative treatment. Studies have shown that Elaeagnus angustifolia (EA) has antioxidant properties. The present study aimed to investigate the effects of EA hydroalcoholic extract on ovariectomy-induced osteoporosis in rats using stereological methods. MATERIAL AND METHODS: 55 female Sprague-Dawley rats were randomly assigned to control, sham operated (normal saline), ovariectomized (OVX), OVX + EA fruit extract (600 mg/kg BW/day), and OVX + estradiol benzoate (3 mg/kg BW) for 16 weeks...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748172/protective-effect-of-tribulus-terrestris-fruit-extract-on-cerulein-induced-acute-pancreatitis-in-mice
#12
Mina Borran, Mohsen Minaiyan, Behzad Zolfaghari, Parvin Mahzouni
OBJECTIVE: Antioxidant, anti-inflammatory, analgesic and antimicrobial activities of Tribulus terrestris (T. terrestris) could be helpful in the treatment of acute pancreatitis; thus, this study was designed to investigate the effects of T. terrestris on cerulein-induced acute pancreatitis in mice. MATERIALS AND METHODS: Three doses (100, 200 and 400 mg/kg) of T. terrestris hydro-alcoholic extract were administered both orally (60 minutes before pancreatitis induction, p...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748171/effect-of-linalool-on-the-acquisition-and-reinstatement-of-morphine-induced-conditioned-place-preference-in-mice
#13
Narjes Pourtaqi, Mohsen Imenshahidi, Bibi Marjan Razavi, Hossein Hosseinzadeh
OBJECTIVE: The effect of linalool, a terpene alcohol found in many plants, which inhibits NMDA receptors, on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) was evaluated in mice. MATERIAL AND METHODS: The effects of different doses of linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg, an NMDA receptor antagonist) and saline, in CPP induced by 40 mg/kg of morphine were investigated in mice. In another experiment, a single injection of morphine (10 mg/kg) reinstated the place reference following extinction of a place preference induced by morphine (40 mg/kg)...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748170/the-effects-of-setarud-on-the-immunological-status-of-hiv-positive-patients-efficacy-of-a-novel-multi-herbal-drug
#14
Mehdi Gholamzadeh Baeis, Ghasem Amiri, Mojtaba Miladinia
OBJECTIVE: This study examines the effect of the addition of IMOD, a novel multi-herbal drug to the highly active anti-retroviral therapy (HAART) regimen, on the immunological status of HIV-positive patients. MATERIALS AND METHODS: A randomized two-parallel-group (HAART group versus HAART+IMOD group), pretest-posttest design was used.Sixty patients with indications for treatment with the HAART regimen participated. One week before and 2 days after the treatments, immunological parameters including total lymphocyte count (TLC) and CD4 cell count were assessed...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748169/evaluation-of-fibrinolytic-and-antioxidant-effects-of-allium-elburzense-bulb-extracts
#15
Leila Safaeian, Behzad Zolfaghari, Mohammadreza Aghaye-Ghazvini, Mahya Behnampour
OBJECTIVE: Allium elburzense is an endemic plant of the family Amaryllidaceae that grows wild in northern Iran with some nutritional and medicinal applications. The present study was aimed to investigate the fibrinolytic and antioxidant effects of A. elburzense bulb extracts. MATERIALS AND METHODS: Hydroalcoholic, aqueous, chloroformic and butanolic extracts were evaluated in this research. In vitro antioxidant assays were performed using total phenolic, DPPH, and FRAP methods...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748168/potentiating-effects-of-perovskia-abrotanoides-karel-on-pentobarbital-induced-sleep
#16
Fatemeh Forouzanfar, Azar Hosseini, Mohammad Sadegh Amiri, Hassan Rakhshandeh
OBJECTIVE: Sleeplessness is the most common sleep disorder. In this study the hypnotic effect of the hydro-alcoholic extract (HAE) of Perovskia abrotanoides Karel. and its water fraction (WF), ethyl acetate fraction (EAF) and n-butanol fraction (NBF) were studied in mice. MATERIALS AND METHODS: The test compounds were administered intraperitoneally to mice 30 min before the administration of sodium pentobarbital (30 mg/kg.). Moreover, the influence of flumazenil on the hypnotic effect of the extracts was evaluated...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748167/therapeutic-efficacy-of-rose-oil-a-comprehensive-review-of-clinical-evidence
#17
REVIEW
Safieh Mohebitabar, Mahboobeh Shirazi, Sodabeh Bioos, Roja Rahimi, Farhad Malekshahi, Fatemeh Nejatbakhsh
OBJECTIVE: Rose oil is obtained from the petals of difference Rosa species especially Rosa centifolia L. and Rosa damascena Mill. Various pharmacological properties have been attributed to rose oil. The aim of the present study was to review the rose oil therapeutic effects which had been clinically evaluated in trial studies. MATERIALS AND METHODS: Google scholar, PubMed, Cochrane Library, and Scopus were searched for human studies which have evaluated the therapeutic effects of rose oil and published in English language until August 2015...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748166/assessment-of-immunomodulatory-activity-of-aqueous-extract-of-calamus-rotang
#18
Amit Gupta, Sushama Ravindra Chaphalkar
OBJECTIVE: There are a number of medicinal plant products which has been used to treat various immunological diseases. Out of these medicinal plants, Calamus rotang has shown several medicinal properties including anti-viral, anti-diabetic, anti-inflammatory effects. Normally, the roots of C. rotang are used in various ailments to cure piles, burning sensation, cough, leprosy and bleeding disorder and also it was used in the treatment of inflammation. In the present study, our group were investigated the immunomodulatory activity of aqueous extract of C...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28348974/capparis-spinosa-l-aqueous-extract-evokes-antidiabetic-effect-in-streptozotocin-induced-diabetic-mice
#19
Mohamed Eddouks, Ahmed Lemhadri, Morad Hebi, Ahmed El Hidani, Naoufel Ali Zeggwagh, Bachir El Bouhali, Lhoussaine Hajji, Remy Burcelin
OBJECTIVE: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice. MATERIALS AND METHODS: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-(3)H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity...
March 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28348973/kidney-stone-formation-and-antioxidant-effects-of-cynodon-dactylon-decoction-in-male-wistar-rats
#20
Alireza Golshan, Parichehr Hayatdavoudi, Mousa Al-Reza Hadjzadeh, Abolfazl Khajavi Rad, Nema Mohamadian Roshan, Abbasali Abbasnezhad, Seyed Mojtaba Mousavi, Roghayeh Pakdel, Batool Zarei, Azita Aghaee
OBJECTIVES: The antioxidant capacity impairs in kidney and urinary bladder of animals with stone disease. Herbal medicine can improve the antioxidant condition of renal tissue. Cynodon dactylon (C. dactylon) is a medicinal plant with antioxidative and diuretic properties and different preparations of this plant have shown promising effects in stone disease. Assessment of the whole plant decoction to prevent kidney stone disease as well as its antioxidant effects was the aim of this paper...
March 2017: Avicenna Journal of Phytomedicine
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