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Avicenna Journal of Phytomedicine

Roghayeh Pakdel, Saeed Niazmand, Mohsen Mouhebati, Mohammad Mahdi Vahedi, Azita Aghaee, Mousa-Al-Reza Hadjzadeh
Objective: The aim of the present study was to compare the effects of Portulaca oleracea (Po) seeds extract and those of valsartan on cardiac function in levothyroxine (T4 )-treated rats. Materials and Methods: Forty Wistar rats were divided into four groups (n=10): control, levothyroxine (T4 ), T4 plus valsartan (T4 -Val) and T4 plus hydro-alcoholic extract of the P. oleracea seeds (T4 -Po). Control group received normal saline. Levothyroxine (100µg/kg/day, i...
May 2018: Avicenna Journal of Phytomedicine
Hamid Reza Poursalehi, Mitra Samareh Fekri, Fariba Sharifi Far, Ali Mandegari, Atefe Izadi, Rahil Mahmoodi, Hadi Nematollahi, Fateme Porgholamhosein, Vahideh Ghorani, Masome Samareh Fekri
Objective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced pulmonary fibrosis model. Materials and Methods: This study was carried out using 52 rats. Pulmonary fibrosis was induced by a single endotracheal injection of bleomycin (5 mg/kg)...
May 2018: Avicenna Journal of Phytomedicine
Fatemeh Namazi, Tahoora Shomali, Pouya Taghikhani, Saied Nazifi
Objective: Finding compounds that could be used for prevention of atherosclerosis (AS) is highly desired. The present study evaluated the protective effects of Urtica dioica (UD, commonly known as stinging nettle) leaf ethanolic extract against high-fat diet-induced AS in rats. Materials and Methods: In this study, 40 male adult Sprauge-Dawley rats were randomly allocated to 4 equal groups and treated as follows for 9 consecutive weeks: (1) Normal control (NC; normal rats that were fed with a basic diet); (2) Atherosclerotic rats (AT; which received no particular treatment); (3) Atherosclerotic rats that received 100 mg/kg/day ethanolic extract of UD orally and (4) Atherosclerotic rats that received simvastatin 4 mg/kg/day orally...
May 2018: Avicenna Journal of Phytomedicine
Bibi Sedigheh Fazly Bazzaz, Bahman Khameneh, Mohammad Reza Zahedian Ostad, Hossein Hosseinzadeh
Objective: In recent years, there has been an increasing interest in using herbal products to overcome bacterial resistance. The aim of this study was to investigate the effect of lemon verbena aqueous extract, verbascoside and caffeine in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus and Escherichia coli strains. Materials and Methods: The MIC and MBC values of different antibacterial agents against bacterial strains were determined...
May 2018: Avicenna Journal of Phytomedicine
Maliheh Moradzadeh, Azar Hosseini, Hasan Rakhshandeh, Azita Aghaei, Hamid Reza Sadeghnia
Objective: Cuscuta campestris or common dodder is a holoparasitic plant that has been valorized for treatment of liver injury and cancer prevention in traditional medicine. Recently, extract of C. campestris had shown moderate antimicrobial properties and cytotoxic effects. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by hydroalcoholic extract of C. campestris (CCE) (12.5-200 µg/ml), as well as arsenic trioxide (As2 O3 , 50 µM), in human leukemic (HL60 and NB4) and normal polymorph nuclear cells after 72 hr treatment...
May 2018: Avicenna Journal of Phytomedicine
Valiollah Hajhashemi, Foroogh Fahmideh, Mostafa Ghanadian
Objective: Berberis vulgaris has antioxidant, hepato--renal protective, antibacterial, lipid lowering, anti-inflammatory and antinociceptive activities. The genus Berberis , has another member called Berberis integerrima which has not been studied for antinociceptive activity and therefore, this study was aimed to examine the antinociceptive effect of total extract and alkaloid fractions of  Berberis integerrima  root in mice. Materials and Methods: Methanolic total extract and alkaloid fractions of the plant namely, fractions A, B, C and D were prepared according to standard methods...
May 2018: Avicenna Journal of Phytomedicine
Wachiryah Thong-Asa, Kanokwan Tilokskulchai, Supin Chompoopong, Mayuree Hantrakul Tantisira
Objective: The present study investigated the effect of standardized Centella asiatica extract on cognition and hippocampal pathology of mild chronic cerebral hypoperfusion (CCH) that was induced by permanent right common carotid artery occlusion (RCO) in rats. Materials and Methods: Sixty-four male Sprague-Dawley rats were randomly divided into four groups of Sham-veh, Sham- C. asiatica , RCO-veh and RCO- C. asiatica , which were further divided into short-term and long-term CCH induction...
May 2018: Avicenna Journal of Phytomedicine
Nahid Maleki-Saghooni, Khadijeh Mirzaeii, Hossein Hosseinzadeh, Ramin Sadeghi, Morvarid Irani
Objective: We performed this systematic review and meta-analysis study to determine saffron ( Crocus sativus ) effectiveness and safety in male infertility problems. Materials and Methods: The databases PubMed, Scopus, Cochrane, Google Scholar, SID, IranMedex and Magiran until July 2016 and reference section of relevant articles, were searched to find both English and Persian clinical trials on male infertility issues that used saffron as medical treatment. Also, the quality of these trials was evaluated by Oxford Center for Evidence Based Medicine checklist...
May 2018: Avicenna Journal of Phytomedicine
Parvin Poorgholam, Parichehreh Yaghmaei, Zahra Hajebrahimi
Objective: Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of amyloid beta in the hippocampus. In recent decades, herbal medicine has been widely used to treat many neurodegenerative disorders,as in comparison to conventional drugs, herbal remedies exert minimal side effects. Here, the effects of thymoquinone, as the main active component of Nigella sativa , on passive avoidance memory in rat model of Alzheimer's disease, were evaluated. Materials and Methods: Hippocampal injection of amyloid beta (Aβ) was used to induce Alzheimer's disease in male Wistar rats, followed by intra peritoneal administrations of 5 and 10 mg/kg thymoquinone on a daily basis for 4 weeks...
May 2018: Avicenna Journal of Phytomedicine
Nazanin Entezari Heravi, Sara Hosseinian, Zohreh Naji Ebrahimi Yazd, Mohammad Naser Shafei, Alireza Ebrahimzadeh Bideskan, Samira Shahraki, Zahra Samadi Noshahr, Fatemeh Motejadded, Farimah Beheshti, Reza Mohebbati, Soghra Parhizgar, Abolfazl Khajavi Rad
Objective: The aim of the present study was to evaluate the possible protective effect of Plantago major ( P. major ) extract against doxorubicin (DXR)-induced renal inflammation in rats. Materials and Methods: 80 male albino rats were randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXR , and Ext1200+DXR. Duration of the study was 35 days and DXR was intravenously injected on the 7th day of the experiment...
March 2018: Avicenna Journal of Phytomedicine
Mahdieh Zaman Emamiyan, Gholamhassan Vaezi, Maryam Tehranipour, Khdije Shahrohkabadi, Abdolhossein Shiravi
Objective: Urolithiasis remains a global problem. Despite the availability of numerous methods, no definite therapeutic agent has been yet introduced for the prevention or treatment of kidney stones. In this study, we evaluated the possible preventive effects of aqueous extract of Cichorium intybus L. (chicory) flowers on ethylene glycol-induced renal calculi in rats. Materials and Methods: A total of 24 Wistar rats were randomly divided into four groups and were treated for 30 days...
March 2018: Avicenna Journal of Phytomedicine
Hadi Khodadadi, Roghayeh Pakdel, Majid Khazaei, Said Niazmand, Kowsar Bavarsad, Mousa Al-Reza Hadjzadeh
Objective: The present study was performed to evaluate the effects of hydro-alcoholic extract of Portulaca oleracea ( P. oleracea ) seeds and Vitamin C on biochemical and hemodynamic parameters in cardiac tissue of rats with subclinical hyperthyroidism. Materials and Methods: Forty eight male rats were divided into six groups of 8 and treated for 4 weeks. T4 group received daily injection of levothyroxine sodium (20 μg/kg) and control group was given daily injection of saline...
March 2018: Avicenna Journal of Phytomedicine
Arshad Ghaffari-Nasab, Fariba Mirzaie Bavil, Rafigheh Ghiasi, Saeed Sadigh-Eteghad, Mohammad Reza Alipour
Objective: Diabetes is associated with vascular complications and impaired angiogenesis. Since angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD™ on miR-503 and CDC25 expression level which are altered in impaired angiogenesis were investigated in heart tissue of diabetic rats. Materials and Methods: Forty male Wistar rats (200-250 g) were randomly classified into 4 groups: control (C), IMOD™ (I), diabetes (D), and diabetes+IMOD™ (D+I)...
March 2018: Avicenna Journal of Phytomedicine
Reza Mohebbati, Kosar Bavarsad, Maryam Rahimi, Hasan Rakhshandeh, Abolfazl Khajavi Rad, Mohammad Naser Shafei
Objective: Ziziphus jujuba stimulates the release of nitric oxide (NO). Because NO is involved in cardiovascular regulations, in this study the effects of hydroalcoholic extract of Z. jujuba on cardiovascular responses in acute NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats were evaluated. Materials and Methods: Rats were divided into 6 group (n=6): 1) saline, 2) L-NAME received (10mg/kg) intravenously, 3) sodium nitroprusside (SNP) (50µg/kg)+L-NAME group received SNP before L-NAME and 4-6) three groups of Z...
March 2018: Avicenna Journal of Phytomedicine
Mohaddeseh Abouhosseini Tabari, Mohammad Reza Youssefi
Objective: Pelargonium roseum Willd. (Geraniaceae) is widely grown as an ornamental plant due to its strong pleasant rose-like odor. The present study evaluates the antitrichomonal effect of P. roseum essential oil (EO) against Trichomonas gallinae both in vitro and in vivo and compares it to that of metronidazole (MTZ) as a standard antitrichomonal drug. Materials and Methods: In vitro assays were accomplished in multi-well plates containing MTZ and EO at final concentrations of 2...
March 2018: Avicenna Journal of Phytomedicine
Badiaa Lyoussi, Khadija Cherkaoui Tangi, Nicole Morel, Mohamed Haddad, Joelle Quetin-Leclercq
Objective: The present investigation was carried out to evaluate the safety of an aqueous extract of the seeds of Calycotome villosa (Poiret) Link (subsp. intermedia) by determining its cytotoxicity and potential toxicity after acute and sub-chronic administration in rodents. Materials and Methods: Cytotoxic activity was tested in cancer and non-cancer cell lines HeLa, Mel-5, HL-60 and 3T3. Acute toxicity tests were carried out in mice by a single oral administration of Calycotome seed-extract (0 - 12 g/kg) as well as intraperitoneal doses of 0 - 5 g/kg...
March 2018: Avicenna Journal of Phytomedicine
Seyed Mostafa Razavi, Mohammad Asadpour, Seyed Hossein Malekpour, Arash Jafari
Objective: The methanolic extracts of Nigella sativa L. seeds (MENS) and Berberis vulgaris L.(MEBV) were investigated for treatment of Haemoproteus columbae- infected pigeons ( Columba livia domestica ). Materials and Methods: One hundred twenty naturally-infected pigeons were randomly divided into four groups of thirty each. Two groups were treated separately with the extracts, while the positive and negative control groups were given buparvaquone ( Butalex ®) and distilled water, respectively...
March 2018: Avicenna Journal of Phytomedicine
Nahid Maleki-Saghooni, Fatemeh Zahra Karimi, Zahra Behboodi Moghadam, Khadigeh Mirzaii Najmabadi
Objective: Premenstrual syndrome (PMS) is one of the most common problems among women of reproductive age. The popularity of complementary/alternative therapies has grown in recent years, and these treatments have been more commonly used by women (48.9%) than men (37.8%). The aim of this systematic review was to assess effectiveness and safety of Iranian herbal medicines for treatment of premenstrual syndrome. Methods: PubMed, Scopus, Cochrane, and Google Scholar were searched along with SID, Magiran and Irandoc up to Dec 2017...
March 2018: Avicenna Journal of Phytomedicine
Tarequl Islam, Md Saddam Hussain, Mohammad Nurul Amin, Ashraful Mahmud Tuhin
Objectives: Swas Kas Chintamani Ras (SKC) is an ayurvedic preparation indicated for respiratory diseases. Our study was aimed to determine the psychopharmacological and neurosafety profile of SKC. Materials and Methods: Psychopharmacological effects and neurosafety profile of this drug were determined by nine complementary test methods namely, open field, locomotor activity, hole cross, hole board test, elevated plus maze, staircase, forced swimming test, and rotarod test...
January 2018: Avicenna Journal of Phytomedicine
Ademola Clement Famurewa, Fidelis Ebele Ejezie
Objective: Literature has confirmed the pathogenic role of cadmium (Cd) and its exposure in the induction of dyslipidemia implicated in the development and increasing incidence of cardiovascular diseases. The current study explored whether polyphenolics isolated from virgin coconut oil (VCO) prevent Cd-induced dyslipidemia and investigate the underlying mechanism of action, in rats. Materials and Methods: Rats were pretreated with VCO polyphenols (10, 20 and 50 mg/kg body weight; orally) 2 weeks prior to concurrent Cd administration (5 mg/kg) for 5 weeks...
January 2018: Avicenna Journal of Phytomedicine
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