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Avicenna Journal of Phytomedicine

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https://www.readbyqxmd.com/read/29062808/acute-effects-of-thermally-processed-pili-canarium-ovatum-engl-pomace-drink-on-plasma-antioxidant-and-polyphenol-status-in-humans
#1
Elizabeth Hashim Arenas, Trinidad Palad Trinidad
OBJECTIVE: Pili (Canarium ovatum, Engl.) pomace is an underutilized agricultural waste that possesses great potential to be regarded as a functional food ingredient. The aim of this study was to measure the polyphenol content and antioxidant activity of pili pomace drink and determine the influence of heating on these parameters. Moreover, it sought to assess the acute effects of thermally processed pili pomace drink on plasma antioxidant and polyphenol status in humans. MATERIAL AND METHODS: Ten healthy adults received a single dose (130 ml) of pili pomace drink following an overnight fasting, and blood was collected at 0, 30, 60, 120 and 240 min after ingestion of pili pomace...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29062807/evaluation-of-the-effects-of-the-hydroalcoholic-extract-of-terminalia-chebula-fruits-on-diazinon-induced-liver-toxicity-and-oxidative-stress-in-rats
#2
Raheleh Ahmadi-Naji, Esfandiar Heidarian, Keihan Ghatreh-Samani
OBJECTIVE: Diazinon causes oxidative stress and dysfunction of the liver. This study was undertaken to evaluate the effects of the hydroalcoholic extract of Terminalia chebula, on some biochemical and histopathological parameters of liver tissue in diazinon-administered rats. MATERIALS AND METHODS: Wistar rats were orally administered with 25 mg/kg body weight diazinon. Vehicle (distilled water) and silymarin (50 mg/kg body weight) were used as the negative and positive control groups, respectively...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29062806/a-simple-sensitive-and-rapid-isocratic-reversed-phase-high-performance-liquid-chromatography-method-for-determination-and-stability-study-of-curcumin-in-pharmaceutical-samples
#3
Farjad Amanolahi, Ali Mohammadi, Reza Kazemi Oskuee, Hooriyeh Nassirli, Bizhan Malaekeh-Nikouei
OBJECTIVE: This study was designed to develop and validate a new reversed-phase high-performance liquid chromatography (RP-HPLC) method based on Q2 (R1) International Conference on Harmonization (ICH) guideline for determination of curcumin in pharmaceutical samples. MATERIALS AND METHODS: The HPLC instrument method was optimized with isocratic elution with acetonitrile: ammonium acetate (45:55, v/v, pH 3.5), C18 column (150 mm×4.6 mm×5 µm particle size) and a flow rate of 1 ml/min in ambient condition and total retention time of 17 min...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29062805/evaluation-of-the-effect-of-soybean-diet-on-interferon-%C3%AE-induced-depression-in-male-mice
#4
Yazdan Azimi Fashi, Azadeh Mesripour, Valiollah Hajhashemi
OBJECTIVE: Interferon-α (IFN) therapy can cause depressive symptom which may lead to drug discontinuation. By interfering with tryptophan pathway, the available level of tryptophan required for serotonin synthesis decreases which could be related to depression. The aim of this study was to evaluate whether soybean diet could improve IFN-induced depression. MATERIALS AND METHODS: Male mice weighing 28±3 g were used in the forced swimming test (FST) as an animal model of depression; also, locomotor activity was recorded...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29062804/effect-of-the-methanolic-extracts-of-different-parts-of-ferula-assa-foetida-on-naloxone-induced-withdrawal-behavior-in-morphine-dependent-mice
#5
Mahnaz Khanavi, Sajad Maadani, Behnaz Farahanikia, Mahdieh Eftekhari, Mohammad Sharifzadeh
OBJECTIVE: Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetida on withdrawal syndrome in morphine-dependent mice. MATERIALS AND METHODS: Aerial parts, roots, and fruits of the plant were separately extracted with 80% MeOH. For induction of dependence, morphine (50, 50 and 75 mg/kg) was injected subcutaneously three times daily (10 am, 1 pm and 4 pm) for three days and a last dose of morphine (50 mg/kg) was administrated on the fourth day...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29062803/the-antioxidant-activity-of-beta-vulgaris-leaf-extract-in-improving-scopolamine-induced-spatial-memory-disorders-in-rats
#6
Shadieh Hajihosseini, Mahbubeh Setorki, Zahra Hooshmandi
OBJECTIVE: Medicinal plants have attracted global attention due to their safety as well as their considerable antioxidant content that helps to prevent or ameliorate various disorders including memory impairments. This study was conducted to investigate the effect of beet root (Beta vulgaris) leaf extract on scopolamine-induced spatial memory impairments in male Wistar rats. MATERIALS AND METHODS: Male Wistar rats were randomly divided into 5 groups (n=10): Control (C), scopolamine 1 mg/kg/day (S), scopolamine+50 mg/kg B...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29062802/modulation-of-lung-inflammation-and-immune-markers-in-asthmatic-rats-treated-by-portulaca-oleracea
#7
Mahsa Kaveh, Akram Eidi, Ali Nemati, Mohammad Hossein Boskabady
OBJECTIVE: Previous studies indicated anti-inflammatory effects for Portulaca oleracea in various inflammatory disorders. In this study, the effects of P. oleracea on bronchoalveolar lavage fluid (BALF) levels of total protein (TP), Phospholipase A2 (PLA2) and IgE in sensitized rats were examined. MATERIALS AND METHODS: Male rats were randomly divided into six groups namely, control (group C), sensitized rats (group S), sensitized animal treated with three concentrations of the extract of P...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29062801/effects-of-ethanolic-extract-of-jasminum-grandiflorum-linn-flowers-on-wound-healing-in-diabetic-wistar-albino-rats
#8
Hiren Hirapara, Vishal Ghori, Ashish Anovadiya, Seema Baxi, Chandrabhanu Tripathi
OBJECTIVE: To evaluate wound healing activity of ethanolic extract of Jasminum grandiflorum Linn. (J. grandiflorum) flowers in diabetic rats. MATERIALS AND METHODS: Streptozotocin-induced diabetic Wistar albino rats were divided into six groups (n=6).Three groups - diabetic control, positive control (that received Glibenclamide) and treatment (that received J. grandiflorum Linn. Flower extract) were operated for excision wounds (EW). These groups were evaluated for wound contraction and re-epithelization...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29062800/tiliacora-triandra-colebr-diels-leaf-extract-enhances-spatial-learning-and-learning-flexibility-and-prevents-dentate-gyrus-neuronal-damage-induced-by-cerebral-ischemia-reperfusion-injury-in-mice
#9
Wachiryah Thong-Asa, Panas Tumkiratiwong, Vasakorn Bullangpoti, Kasem Kongnirundonsuk, Kanokwan Tilokskulchai
OBJECTIVE: The present study investigated the effects of a local Thai vegetable, Tiliacora triandra (Colebr.) Diels, also known as Yanang, against cerebral ischemia/reperfusion injury in mice. MATERIALS AND METHODS: Thirty male ICR mice were divided into three experimental groups of BLCCAO + 10% Tween 80, BLCCAO + T. triandra 300 mg/kg, and BLCCAO + T. triandra 600 mg/kg. Cerebral ischemia/reperfusion was induced by three minutes of bilateral common carotid artery occlusion (BLCCAO) followed by 18 days of reperfusion...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884087/curcumin-attenuates-harmful-effects-of-arsenic-on-neural-stem-progenitor-cells
#10
Ali Jahanbazi Jahan-Abad, Parastoo Morteza-Zadeh, Sajad Sahab Negah, Ali Gorji
OBJECTIVE: Arsenic, an environmental pollutant, decreases neuronal migration as well as cellular maturation and inhibits the proliferation of neural progenitor cells. Curcumin has been described as an antioxidant and neuroprotective agent with strong therapeutic potential in some neurological disorders. Human adipose-derived stem cells (hADSCs), a source of multipotent stem cells, can self-renew and differentiate into neural cells. The aim of the present study was to investigate the preventive effect of curcumin against arsenic toxic effects on the viability, telomerase activity, and apoptosis of neural stem/progenitor cells (NSPCs) derived from hADSCs...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884086/anti-nociceptive-and-anti-inflammatory-effects-of-the-methanolic-extract-of-opuntia-humifusa-stem
#11
Bhesh Raj Sharma, Chul Min Park, Jong Won Choi, Dong Young Rhyu
OBJECTIVE: Opuntia humifusa (O. humifusa) Raf. has been used for the prevention and treatment of rheumatoid arthritis, inflammation, and cancer. Our study was designed to unveil the anti-nociceptive and anti-inflammatory effects of the methanolic extract of O. humifusa Raf stem (OHS). MATERIALS AND METHODS: The anti-nociceptive effect was measured by hot plate, acetic acid-induced writhing, and tail flick assays in mice and rats. Moreover, the anti-inflammatory effect was measured by vascular permeability and carrageenan and serotonin-induced paw edema tests in rats...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884085/anti-anxiety-and-hypnotic-effects-of-ethanolic-and-aqueous-extracts-of-lippia-citriodora-leaves-and-verbascoside-in-mice
#12
Bibi Marjan Razavi, Naser Zargarani, Hossein Hosseinzadeh
OBJECTIVES: The extract of Lippia citriodora and its main component, verbascoside, are known for their hypnotic effects in traditional medicine. In this study, the anxiolytic and hypnotic effects of L. citriodora leave extracts and verbascoside were evaluated in mice. MATERIALS AND METHODS: Animals were divided into 11 groups of six mice each. Group I received normal saline, Group II received Diazepam (2 mg/kg) as positive control, Groups III, IV and V received L...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884084/crocin-prevents-acute-angiotensin-ii-induced-hypertension-in-anesthetized-rats
#13
Mohammad Naser Shafei, Abdolali Faramarzi, Abolfazl Khajavi Rad, Akbar Anaeigoudari
OBJECTIVE: Angiotensin II (Ang II), the main product of renin-angiotensin system (RAS) has a well-known role in cardiovascular regulation. Over-production of Ang II is one of the important underlying mechanisms of hypertension. In this study, the effect of crocin on cardiovascular responses in rats with acute hypertension induced by Ang II was evaluated. MATERIALS AND METHODS: Rats were divided into six groups (n = 6): 1) Control: rats that received saline, 2) Ang II: rats that received Ang II (300 ng/kg) infused in two min, 3) Losartan (Los) + Ang II : rats that received Los (10 mg/kg, i...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884083/hydro-alcoholic-extract-of-matricaria-recutita-exhibited-dual-anti-spasmodic-effect-via-modulation-of-ca-2-channels-no-and-pka2-kinase-pathway-in-rabbit-jejunum
#14
Hamidreza Yazdi, Akhtar Seifi, Shima Changizi, Vahid Khori, Fatemeh Hossini, Ali Davarian, Yahya Jand, Ayesheh Enayati, Masumeh Mazandarani, Fateme Nanvabashi
OBJECTIVE: Several studies have shown the antispasmodic activity of Matricariarecutita without detailing the underlying mechanism(s). The present study was designed to determine whether the antispasmodic mechanisms of M. recutita extract mediated via histaminergic/cholinergic receptors, Ca(2+)channels, activation of PKA2 and NO release in isolated rabbit jejunum. MATERIALS AND METHODS: The concentration- dependent (3 × 10(-3)-1.3 × 10(-2) mg/ml) antispasmodic effect of the hydro-alcoholic extract of M...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884082/effects-of-pomegranate-seed-oil-on-oxidant-antioxidant-balance-in-heart-and-kidney-homogenates-and-mitochondria-of-diabetic-rats-and-high-glucose-treated-h9c2-cell-line
#15
Hamid Mollazadeh, Mohammad Taher Boroushaki, Mohammad Soukhtanloo, Amir Reza Afshari, Mohammad Mahdi Vahedi
OBJECTIVE: Oxidative stress is a major cause of diabetes complications. The present study aimed to investigate the beneficial effects of Pomegranate Seed Oil (PSO) on diabetes-induced changes in oxidant/antioxidant balance of the kidney, heart and mitochondria from rats and H9c2 cell line. MATERIALS AND METHODS: In these in vivo and in vitro studies, male rats were divided into four groups (twelve each): group 1 served as control, group 2-4 received a single dose of streptozotocin (60 mg/kg, i...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884081/the-effect-of-ginger-herbal-spray-on-reducing-xerostomia-in-patients-with-type-ii-diabetes
#16
Homeira Mardani, Alireza Ghannadi, Bahareh Rashnavadi, Razieh Kamali
OBJECTIVE: The aim of the present study is to evaluate the effect of ginger herbal spray on reducing dry mouth in patients with Type II diabetes. MATERIALS AND METHODS: This clinical trial was conducted on 20 patients with Type II diabetes suffering from dry mouth. The control individual for each patient was the same patient himself/herself. Each patient filled out his/her questionnaire at three different times, (before treatment, after treatment with placebo, and after taking the drug)...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884080/antibacterial-antioxidant-and-cell-proliferative-properties-of-coccinia-grandis-fruits
#17
Prashant Sakharkar, Balwantsinh Chauhan
OBJECTIVE: Little knowledge is available on the antimicrobial and antioxidant properties of Coccina grandis fruits and no study has reported on its cell proliferative property. The aim of this study was to examine the antimicrobial, antioxidant and cell proliferative property of fruits of C. grandis. MATERIALS AND METHODS: Fruits of C. grandis were extracted using water; ethanol and acetone by cold and hot Soxhlet extraction. The antibacterial activities of the extracts were tested against Staphylococcusaureus,Enterococcusfaecalis,Escherichiacoli and Pseudomonasaeruginosa using the modified Kirby-Bauer diffusion method and compared against erythromycin...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28884079/podophyllotoxin-a-novel-potential-natural-anticancer-agent
#18
REVIEW
Hamidreza Ardalani, Amir Avan, Majid Ghayour-Mobarhan
OBJECTIVE: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. MATERIALS AND METHODS: Google scholar, PubMed and Scopus were searched for literatures which have studied identification, characterization, fermentation and therapeutic effects of PTOX and published in English language until end of 2016...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748174/antiplasmodial-activity-and-cytotoxicity-of-ethanol-extract-of-zea-mays-root
#19
Jude Efiom Okokon, Bassey Sunday Antia, Bala Adamu Azare, Patience Jude Okokon
OBJECTIVE: Zea mays root decoction that has been traditionally used for the treatment of malaria by various tribes in Nigeria, was evaluated for antimalarial potential against malaria parasites using in vivo and in vitro models. MATERIALS AND METHODS: The root extract of Zea mays was investigated for antimalarial activity against Plasmodium berghei in mice using rodent malaria models; suppressive, prophylactic and curative tests and in vitro antiplasmodial activity against chloroquine-sensitive (Pf 3D7) and resistant (Pf INDO) strains of Plasmodium falciparum using SYBR green assay method...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28748173/stereological-investigation-of-the-effect-of-elaeagnus-angustifolia-fruit-hydroalcoholic-extract-on-osteoporosis-in-ovariectomized-rats
#20
Mohmmad Hossein Dabbaghmanesh, Ali Noorafshan, Pedram Talezadeh, Nader Tanideh, Farhad Koohpeyma, Aida Iraji, Marzieh Bakhshayeshkaram, Nima Montazeri-Najafabady
OBJECTIVE: Postmenopausal osteoporosis is characterized by increased fracture risk. However, each approved treatment has specific side effects. Therefore, foods with plant origins have increasingly attracted attention as an alternative treatment. Studies have shown that Elaeagnus angustifolia (EA) has antioxidant properties. The present study aimed to investigate the effects of EA hydroalcoholic extract on ovariectomy-induced osteoporosis in rats using stereological methods. MATERIAL AND METHODS: 55 female Sprague-Dawley rats were randomly assigned to control, sham operated (normal saline), ovariectomized (OVX), OVX + EA fruit extract (600 mg/kg BW/day), and OVX + estradiol benzoate (3 mg/kg BW) for 16 weeks...
May 2017: Avicenna Journal of Phytomedicine
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