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Avicenna Journal of Phytomedicine

Aideé Itzel Arcos-Martínez, Omar David Muñoz-Muñiz, Miguel Ángel Domínguez-Ortiz, Margarita Virginia Saavedra-Vélez, Maribel Vázquez-Hernández, María Gabriela Alcántara-López
OBJECTIVE: Argemone mexicana is a Papaveracea plant; some reports have shown their antibacterial, anti-cancer, sedative and probably anti-anxiety properties. From their aerial parts, flavonoids and alkaloids have been isolated, which are intrinsically related to some actions on the central nervous system. The aim of this study was to evaluate the anxiolytic-like effects of the plant, using its ethanolic extract and alkaloid-enriched extract obtained from fresh leaves. MATERIAL AND METHODS: Phytochemical screening was carried out together with evaluation of antioxidant capacity and the enrichment of alkaloids present in the extract...
July 2016: Avicenna Journal of Phytomedicine
Siamak Beheshti, Rezvan Aghaie
OBJECTIVE: Frankincense improves memory in different models of learning. However, its influence on models of Alzheimer's disease (AD) has not been studied widely. In the present study, the therapeutic effect of frankincense was evaluated in a model of AD induced by i.c.v administration of streptozotocin. MATERIALS AND METHODS: Under stereotaxic surgery, two guide cannulas were implanted in the lateral ventricles of adult male Wistar rats weighing 230-270 g. One group received streptozotocin (1...
July 2016: Avicenna Journal of Phytomedicine
Tabassom Mohajer Shojai, Arash Ghalyanchi Langeroudi, Vahid Karimi, Abbas Barin, Naser Sadri
OBJECTIVE: Garlic is a plant has been used as a flavor, and anti-microbial and anti-diarrheal agent. Infectious bronchitis virus (IBV) is a coronavirus. The available vaccines against IBV cannot cover new variants. This study evaluated the inhibitory effects of garlic extract on IBV. MATERIALS AND METHODS: The constituents of garlic extract were detected by gas chromatography. This study was done in four groups of embryonic SPF eggs; first group was used for virus titration; second group received the mixture of different virus titration and constant amount of garlic extract; third group received 10(-3) titration of virus and after 8 hr received garlic extract and the last group received different dilutions of garlic extract...
July 2016: Avicenna Journal of Phytomedicine
Fatemeh Forouzanfar, Ahmad Ghorbani, Mahmoud Hosseini, Hassan Rakhshandeh
OBJECTIVE: Insomnia is accompanied by several health complications and the currently used soporific drugs can induce several side effects such as psychomotor impairment, amnesia, and tolerance. The present study was planned to investigate the sleep prolonging effect of Pinus eldarica. MATERIALS AND METHODS: Hydroalcoholic extract (HAE) of P. eldarica, its water fraction (WF), ethyl acetate fraction (EAF) and n-butanol fraction (NBF) were injected (intraperitoneally) to mice 30 min before administration of pentobarbital...
July 2016: Avicenna Journal of Phytomedicine
Mina Taati, Esmaeal Tamaddonfard, Amir Erfanparast, Hamid Ghasemi
OBJECTIVE: Crocin and safranal, as the major constituents of saffron, have many biological activities. This study investigated the effects of crocin and safranal on yawning response induced by intracerebroventricular (i.c.v.) injection of histamine in rats. MATERIALS AND METHODS: In ketamine/xylazine-anesthetized rats, a guide cannula was implanted in the right ventricle of the brain and yawning induced by i.c.v. injection of histamine. Crocin and safranal were intraperitoneally (i...
July 2016: Avicenna Journal of Phytomedicine
Seyed Hadi Mousavi, Behnaz Naghizade, Solmaz Pourgonabadi, Ahmad Ghorbani
OBJECTIVE: Oxidative stress plays a key role in the pathophysiology of brain ischemia and neurodegenerative disorders. Previous studies indicated that Viola tricolor and Viola odorata are rich sources of antioxidants. This study aimed to determine whether these plants protect neurons against serum/glucose deprivation (SGD)-induced cell death in an in vitro model of ischemia and neurodegeneration. METHODS AND MATERIAL: The PC12 neuronal cells were pretreated for 4 hr with 1 to 50 µg/ml of V...
July 2016: Avicenna Journal of Phytomedicine
Mansureh Kamali, Susan Khosroyar, Hossein Kamali, Tooba Ahmadzadeh Sani, Ameneh Mohammadi
OBJECTIVE: Dracocephalum kotschyi (Lamiaceae family) has been used in traditional medicine for stomach and liver disorders, headache and congestion. In the present study, we have investigated phytochemical properties and antioxidant activities of dichloromethane, ethyl acetate and methanol extracts of D.kotschyi. MATERIAL AND METHODS: Antioxidant activities of extracts were evaluated using the integration of HPLC-DPPH and ferric reducing antioxidant power (FRAP) methods...
July 2016: Avicenna Journal of Phytomedicine
Vahideh Fatoorechi, Marjan Rismanchi, Javad Nasrollahzadeh
OBJECTIVE: Persian leek is one of the most widely used herbal foods among Iranians. In this study, effects of oral administration of Persian leek on plasma and liver lipids were examined in hamster. MATERIALS AND METHODS: Male Syrian hamsters were randomly divided into three groups: control (standard diet), high fat control (high-fat/high-cholesterol diet), Persian leek (high-fat/high-cholesterol diet + 1% per weight of diet from dried powdered Persian leek) for 14 weeks...
July 2016: Avicenna Journal of Phytomedicine
Mohamad Ali Geryani, Davood Mahdian, Seyed Hadi Mousavi, Azar Hosseini
OBJECTIVE: Perovskia abrotanoides Karel, belongs to the family Lamiaceae and grows wild alongside the mountainous roads inarid and cold climate of Northern Iran. The anti-tumor activity of P. abrotanoides root extract has been shown previously. This study was designed to examine in vitro anti-proliferative and pro-apoptotic effects of flower extract of P. abrotanoides on MCF-7 and Hela cell lines. MATERIALS AND METHODS: Cells were cultured in DMEM medium with 10% fetal bovine serum, 100 units/ml penicillin and 100 µg/ml streptomycin and incubated with different concentrations of plant extracts...
July 2016: Avicenna Journal of Phytomedicine
Maryam Sarbishegi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Moharram Valizadeh, Mahboobeh Doostkami
OBJECTIVE: Oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. The beneficial effects of antioxidant nutrients, as well as complex plant extracts, on cerebral ischemia-reperfusion injuries are well known. This study was conducted to determine the effects of the hydro-alcoholic root extract of Withania coagulans on CA1 hippocampus oxidative damages following global cerebral ischemia/reperfusion in rat. MATERIALS AND METHODS: Male Wistar rats were randomly divided in five groups: control, sham operated, Ischemia/ Reperfiusion (IR), and Withania Coagulans Extract (WCE) 500 and 1000mg/kg + I/R groups...
July 2016: Avicenna Journal of Phytomedicine
Hamid Reza Rahimi, Reza Nedaeinia, Alireza Sepehri Shamloo, Shima Nikdoust, Reza Kazemi Oskuee
OBJECTIVE: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). A wide range of studies have been conducted on the physicochemical traits and pharmacological effects of curcumin on different diseases like cardiovascular diseases, diabetes, cancer, rheumatoid arthritis, Alzheimer's, inflammatory bowel disease (IBD), and even it has wound healing...
July 2016: Avicenna Journal of Phytomedicine
Mojtaba Shahnazi, Abbas Azadmehr, Robabeh Latifi, Reza Hajiaghaee, Mehrzad Saraei, Mahmood Alipour
OBJECTIVE: Hydatidosis is one of the most important zoonotic diseases and surgery is still the main treatment for this problem. One of the side effects of hydatid cyst surgery is recurrence, thus, searching and assessment of some new agents such as medicinal plant extracts are very important. In the present study, the scolicidal effect of ethanolic extract of Ziziphora tenuior (Z. tenuior) was investigated. MATERIALS AND METHODS: Protoscolices were aseptically collected from sheep livers containing hydatid cyst and used in the experiments...
July 2016: Avicenna Journal of Phytomedicine
Amit Kumar Sharma, Mayank Gangwar, Dharmendra Kumar, Gopal Nath, Akhoury Sudhir Kumar Sinha, Yamini Bhushan Tripathi
OBJECTIVE: This study aims to evaluate the antimicrobial activity, phytochemical studies and thin layer chromatography analysis of machine oil, hexane extract of seed oil and methanol extract of presscake & latex of Jatropha curcas Linn (family Euphorbiaceae). MATERIALS AND METHODS: J. curcas extracts were subjected to preliminary qualitative phytochemical screening to detect the major phytochemicals followed by its reducing power and content of phenol and flavonoids in different fractions...
July 2016: Avicenna Journal of Phytomedicine
Maryam Mohadjerani, Rahman Hosseinzadeh, Maryam Hosseini
OBJECTIVE: The objective of this research was to investigate the chemical composition and antibacterial activities of the fatty acids and essential oil from various parts of Ligularia persica Boiss (L. persica) growing wild in north of Iran. MATERIALS AND METHODS: Essential oils were extracted by using Clevenger-type apparatus. Antibacterial activity was tested on two Gram-positive and two Gram-negative bacteria by using micro dilution method. RESULTS: GC and GC∕MS analysis of the oils resulted in detection of 94%, 96%, 93%, 99% of the total essential oil of flowers, stems, roots and leaves, respectively...
May 2016: Avicenna Journal of Phytomedicine
Atefeh Araghi, Saeed Seifi, Reza Sayrafi, Parisa Sadighara
OBJECTIVE: Rice Bran Oil (RBO) is extracted from the outer layer of rice. Little information is available regarding its safety. The present study was conducted to assess its safety in chicken embryo model. MATERIALS AND METHODS: RBO was injected on day 4 of incubation of chickens. The tissues and serum samples were collected. Oxidative stress parameters in the liver, kidney and brain and biochemical parameters of serum were measured. The deformities were also investigated...
May 2016: Avicenna Journal of Phytomedicine
Muhammad Aslam, Nuzhat Sultana
OBJECTIVE: Scientific studies have shown that Vitis vinifera (V. vinifera) contains flavonoids and stillbenoids. Flavonoids are well known to possess anxiolytic activities. In view of the idea that flavonoids present in V. vinifera could be useful in anxiety, we evaluated anxiolytic-like activity of V. vinifera juice (VVJ). MATERIALS AND METHODS: Light/dark box and the open field test were used to assess the anxiolytic potential of V. vinifera juice (VVJ). The juice was given orally by gavage at the dose of 4 and 8 mL/kg body weight...
May 2016: Avicenna Journal of Phytomedicine
Masoud Dadashi, Ali Hashemi, Gita Eslami, Fatemeh Fallah, Hossein Goudarzi, Soroor Erfanimanesh, Arezou Taherpour
OBJECTIVE: There are few therapeutic options for treatment of multidrug resistant Klebsiella pneumoniae isolates as a hospital infectious agent (nosocomial infection). The aim of this study was to evaluate the antibacterial activity of Zataria multiflora Boiss extracts against ESBL-producing Klebsiella pneumoniae strains. MATERIALS AND METHODS: This study was conducted on 100 K. pneumoniae isolates from two hospitals in Tehran, Iran. Antibiotic susceptibility tests were performed by Kirby-Bauer disc diffusion and microdilution broth methods and detection of ESBL was carried out according to CLSI guidelines...
May 2016: Avicenna Journal of Phytomedicine
Soheila Sepahi, Abbas Jafarian-Dehkordi, Maryam Mirlohi, Kobra Shirani, Mahmoud Etebari
OBJECTIVE: Irinotecan is a botanical derivative and an anti-cancer drug with cytotoxic and genotoxic effects. The present study evaluated the effect of Lactobacillus plantarum A7 on the genotoxic activity of irinotecan in a hepatocellular carcinoma cell line (HepG2) by comet assay. MATERIALS AND METHODS: HepG2 were incubated with irinotecan (100 µM), heat-killed cells (0.025 µg/ml) + irinotecan (100 µM), and cell-free supernatants (0.5 and 1 µg/ml) of L. plantarum A7 + irinotecan (100 µM)...
May 2016: Avicenna Journal of Phytomedicine
Zahra Shahamat, Saeid Abbasi-Maleki, Saeid Mohammadi Motamed
OBJECTIVE: Pimpinella anisum (P. anisum ) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. In this study the antidepressant-like effect of aqueous and ethanolic extracts of P. anisum fruit in mice was investigated. MATERIALS AND METHODS: Forced swimming test (FST) and tail suspension test (TST) were used to determine the antidepressant effects of P. anisum (50, 100 and 200 mg/kg, i...
May 2016: Avicenna Journal of Phytomedicine
Zeinab Nikniaz, Reza Mahdavi, Seyed Jamal Ghaemmaghami, Neda Lotfi Yagin, Leila Nikniaz
OBJECTIVE: Determination and comparison of the effect of infusion time on the antioxidant activity and total polyphenol contents of bagged and loosely packed black teas. MATERIALS AND METHODS: For twenty loosely packed and eleven bagged tea samples, the antioxidant activity and total polyphenol content were analyzed using FRAP and Folin-Ciocalteau methods, respectively. The ANOVA with Tukey post-hoc test and independent t-test were used for statistical analysis...
May 2016: Avicenna Journal of Phytomedicine
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