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Asia-Pacific Journal of Ophthalmology

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https://www.readbyqxmd.com/read/29082677/predictive-value-of-baseline-biochemical-parameters-for-clinical-response-of-macular-edema-to-bevacizumab-in-eyes-with-central-retinal-vein-occlusion-a-retrospective-analysis
#1
V G Madanagopalan, Bibha Kumari
PURPOSE: To evaluate the influence of baseline biochemical parameters on the improvement in best corrected visual acuity (BCVA) and reduction in central foveal thickness (CFT) in patients treated with intravitreal bevacizumab (IVB; Avastin, Genentech, Inc) for macular edema (ME) secondary to central retinal vein occlusion (CRVO). DESIGN: A retrospective study. METHODS: Seventy eyes of 70 participants with CRVO who underwent IVB for ME and had at least 1 month of follow-up after the last injection were studied...
October 30, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29076303/anti-vegf-therapy-for-diabetic-eye-diseases
#2
Bobak Bahrami, Thomas Hong, Mark C Gilles, Andrew Chang
Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness in the working-age population. The identification of vascular endothelial growth factor (VEGF) as a key mediator in the pathogenesis of DR has revolutionized the management of this vision-threatening disease. There is now strong evidence supporting intravitreal anti-VEGF therapy as first line in the management of sight-threatening diabetic macular edema (DME), along with a growing body of evidence to support the use of anti-VEGF drugs for proliferative DR...
October 26, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29063741/optic-nerve-head-hemorrhages-associated-with-posterior-vitreous-detachment
#3
Philip J Polkinghorne
PURPOSE: To report and evaluate the clinical and optical coherence tomography (OCT) features of optic nerve hemorrhages (ONH) associated with spontaneous posterior vitreous detachment (PVD). DESIGN: A prospective case series conducted at a private ophthalmic practice in Auckland, New Zealand. METHODS: A consecutive series of patients presenting at a private multispecialty practice in Auckland, New Zealand, with symptoms of PVD with ONH underwent imaging of the optic nerve with digital retinal photography and OCT...
October 24, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29063740/submacular-hemorrhage-visual-outcomes-and-prognostic-factors
#4
Paradee Kunavisarut, Tipparut Thithuan, Direk Patikulsila, Janejit Choovuthayakorn, Nawat Watanachai, Voraporn Chaikitmongkol, Kessara Pathanapitoon, Aniki Rothova
PURPOSE: To describe causes, visual outcomes, and prognostic factors in patients with submacular hemorrhage (SMH). DESIGN: Retrospective case review. METHODS: We performed a retrospective review of SMH with a size of at least 1 disc diameter. SMH causes were classified into 3 groups: 1) neovascular age-related macular degeneration (nAMD), 2) polypoidal choroidal vasculopathy (PCV), and 3) other miscellaneous causes. RESULTS: Ninety-eight eyes of 98 patients were included...
October 23, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29057640/the-armour-study-anti-vegf-in-neovascular-amd-our-understanding-in-a-real-world-indian-setting
#5
Nimesh Jain, Naresh Kumar Yadav, Chaitra Jayadev, Priya Srinivasan, Ashwin Mohan, Bhujang K Shetty
PURPOSE: The aim of our study was to share our experience with anti‒vascular endothelial growth factor (anti-VEGF) injections in the treatment of neovascular age-related macular degeneration (nAMD) in a real-world setting. DESIGN: A retrospective, observational study. METHODS: Patients of Indian origin with nAMD receiving anti-VEGF with a minimum follow-up of 12 months were enrolled in this study. In group 1, patients were treated on a pro re nata (PRN) basis; in group 2, patients received a loading dose (3 injections) and were then treated on a PRN basis...
October 23, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29057641/anti-vascular-endothelial-growth-factor-therapy-for-myopic-choroidal-neovascularization
#6
Danny S C Ng, Timothy Y Y Lai, Chui Ming Gemmy Cheung, Kyoko Ohno-Matsui
Myopic choroidal neovascularization (CNV) is one of the most vision-impairing complications in patients with pathologic myopia. It is also one of the most frequently encountered non‒age-related macular degeneration causes of CNV and affects young patients in the working age group. Fluorescein angiography (FA) and spectral domain optical coherence tomography (OCT) are generally indicated to confirm the diagnosis of active myopic CNV before initiation of treatment. Without treatment, natural history studies have shown that the vision outcome can be very poor...
October 20, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971633/anti-vegf-therapy-for-neovascular-amd-and-polypoidal-choroidal-vasculopathy
#7
Gemmy Chui Ming Cheung, Timothy Y Y Lai, Fumi Gomi, Paisan Ruamviboonsuk, Adrian Koh, Won Ki Lee
Anti‒vascular endothelial growth factor (anti-VEGF) therapy has revolutionized the treatment of neovascular age-related macular degeneration (AMD). This review will summarize the current evidence of anti-VEGF therapy in neovascular AMD, including subtypes of retinal angiomatous proliferation and polypoidal choroidal vasculopathy (PCV). Importantly, 2 large multicenter randomized clinical trials evaluating the safety and efficacy of anti-VEGF monotherapy and combination with photodynamic therapy (PDT) have recently reported initial first-year outcomes...
October 3, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971631/intravitreal-ziv-aflibercept-clinical-effects-and-economic-impact
#8
Sumit Randhir Singh, Avantika Dogra, Michael Stewart, Taraprasad Das, Jay Chhablani
During the past decade, drugs that inhibit the actions of vascular endothelial growth factor (VEGF) have become standard-of-care treatment for a variety of chorioretinal vascular conditions. The off-label, intravitreal use of ziv-aflibercept (Zaltrap) has provided clinicians with an additional cost-effective drug. The commercial preparation of ziv-aflibercept contains the same aflibercept (VEGF-trap) molecule as Eylea but has a much higher osmolarity (1000 mOsm/kg vs 300 mOsm/kg). Initial concerns regarding cytotoxicity and long-term safety of intravitreal ziv-aflibercept have been largely negated after a series of publications failed to identify adverse ocular and systemic side effects...
October 3, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971630/visual-acuity-improves-in-children-and-adolescents-with-idiopathic-infantile-nystagmus
#9
Ben W R Balzer, Caroline J Catt, Milia Bou-Abdou, Frank J Martin
PURPOSE: Idiopathic infantile nystagmus is associated with reduced visual acuity. Recent work has linked extraocular muscle surgery to improvements in visual acuity through childhood but no work has reported long-term secular trends in visual acuity in infantile nystagmus. Our aim is to describe visual acuity changes for children and adolescents with idiopathic infantile nystagmus to allow comparison for future interventional studies. DESIGN: Retrospective chart review...
October 3, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971632/paradigms-for-pediatric-cataract-surgery
#10
Viraj Vasavada
Pediatric cataract surgery has seen several advances in techniques, technologies, and conceptual practices. Pediatric cataract management heavily depends on a combined effort, not only from the ophthalmologist, but also the parents, the anesthetists, and the supporting staff members (eg, optometrists, orthoptists, patient coordinators). Surgical management, though critical, is not the only consideration for these children. Continuing visual rehabilitation and monitoring for complications remain key elements even after the surgery is done...
September 25, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28933517/new-treatment-modalities-for-neovascular-age-related-macular-degeneration
#11
Patricio G Schlottmann, Arturo A Alezzandrini, Marcelo Zas, Francisco J Rodriguez, José D Luna, Lihteh Wu
Age-related macular degeneration (AMD) is considered one of the main causes of severe vision loss in older adults. The neovascular form (nAMD) is an advanced stage, which is responsible for the most severe vision loss. Vascular endothelial growth factor (VEGF) is at present the main factor that leads to the development of a neovascular membrane and the increased leakage from the membrane to the retina. At present, anti-VEGF therapy is the only treatment that achieves vision gains in many patients and halts progression in most of them...
September 14, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28906084/updates-on-the-epidemiology-of-age-related-macular-degeneration
#12
Jost B Jonas, Chui Ming Gemmy Cheung, Songhomitra Panda-Jonas
This meta-analysis reports on current estimates of the prevalence of age-related macular degeneration (AMD) based on a review of recent meta-analyses and literature research. Within an age of 45-85 years, global prevalences of any AMD, early AMD, and late AMD were 8.7% [95% credible interval (CrI), 4.3‒17.4], 8.0% (95% CrI, 4.0‒15.5), and 0.4% (95% CrI, 0.2-0.8). Early AMD was more common in individuals of European ancestry (11.2%) than in Asians (6.8%), whereas prevalence of late AMD did not differ significantly...
September 14, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905541/the-role-of-new-imaging-methods-in-managing-age-related-macular-degeneration
#13
Stephen James Talks, Akhunzada Muhammad Aftab, Imran Ashfaq, Taha Soomro
The use of imaging for age-related macular degeneration (AMD) depends on how it benefits clinical management and on reimbursement. The latter should relate to the former. This review assesses how different forms of AMD can be imaged and what information this provides. For nonneovascular AMD high-resolution optical coherence tomography (OCT), autofluorescence, and near infrared imaging can identify the type of drusen, such as reticular pseudodrusen, which influences prognosis, and the amount of atrophy, for which phase 3 trials are underway...
September 14, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905539/new-treatment-modalities-for-geographic-atrophy
#14
Rathika Kandasamy, Sanjeewa Wickremasinghe, Robyn Guymer
Age-related macular degeneration (AMD) is a significant cause of global visual morbidity and is projected to affect 288 million people by the year 2040. The advent of treatment with anti‒vascular endothelial growth factor (anti-VEGF) drugs has revolutionized the treatment of neovascular AMD (nAMD) but there have been no similar breakthroughs for the treatment of geographic atrophy (GA) to retard its progression. The advancements in imaging and new understanding of disease mechanisms, based on molecular and genetic models, have paved the way for the development of novel experimental treatment options for GA that aim to cater to a thus far largely unmet need...
September 14, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28868833/evaluation-of-interleukin-17-and-interleukin-23-in-pterygium-immunohistochemistry-study
#15
Kiew Ing Tiong, Aida Zairani Mohd Zahidin, S Kala A/P Sumugam, Joseph Uchang, Hazlita Dato' Mohd Isa
PURPOSE: To compare the interleukin-17 (IL-17) and interleukin-23 (IL-23) positive cell counts between pterygium and normal conjunctiva. DESIGN: A case-control study. METHODS: This study received ethical approval (NMRR Research ID 23957) and informed consent was obtained from all participants. It involved 20 participants with 20 samples of pterygium and 20 samples of normal conjunctiva that were obtained from the same eye of each participant...
September 4, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28868832/combined-cataract-extraction-with-pars-plana-vitrectomy-and-metallic-intraocular-foreign-body-removal-through-sclerocorneal-tunnel-using-a-novel-magnet-handshake-technique
#16
Pankaja Dhoble, Ashish Khodifad
PURPOSE: To study the outcomes of combined cataract extraction with pars plana vitrectomy (PPV) and metallic intraocular foreign body (IOFB) removal through a sclerocorneal tunnel using the "magnetic handshake" technique. DESIGN: A retrospective review. METHODS: Retrospective review of case records of 14 patients from 2010 to 2016 with metallic IOFB and traumatic cataract was performed. Cataract extraction was combined with PPV. Two intraocular magnets (IOMs) introduced through 20-gauge vitrectomy port and sclerocorneal tunnel helped achieve safe delivery of IOFB outside the globe by the "magnetic handshake" technique...
September 4, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28930381/intraocular-pressure-and-big-bubble-diameter-in-deep-anterior-lamellar-keratoplasty-an-ex-vivo-microscope-integrated-oct-with-heads-up-display-study
#17
Paramjit K Bhullar, Oscar M Carrasco-Zevallos, Alexandria Dandridge, Neel D Pasricha, Brenton Keller, Liangbo Shen, Joseph A Izatt, Cynthia A Toth, Anthony N Kuo
PURPOSE: To investigate the relationship between intraocular pressure (IOP) and big bubble (BB) formation in a model of deep anterior lamellar keratoplasty (DALK). DESIGN: Ex-vivo. METHODS: Corneoscleral buttons from human donors were loaded onto an artificial anterior chamber connected to a column of balanced salt solution. A surgeon-in-training learned to perform DALK via the BB technique using swept-source microscope-integrated optical coherence tomography (SS-MIOCT) with heads-up display (HUD)...
September 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28930380/refractive-surgery-history-in-the-making
#18
EDITORIAL
Samuel C Faith, Vishal Jhanji
No abstract text is available yet for this article.
September 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905540/nanosecond-laser-cataract-surgery-in-locs-iii-grade-4-and-5-a-case-series
#19
Gangolf Sauder, Elena Ruf, Sarah Moedl, Reinhardt Thyzel
PURPOSE: A major obstacle to the widespread implementation of nanosecond laser cataract removal has been its limited efficacy in cases when the cataract is harder than Lens Opacities Classification System III (LOCS III ) grade 3. The latest technological modifications seem to have overcome this obstacle. DESIGN: A case series. METHODS: This study presents a case series of 17 consecutive patients with a cataract classified as harder than LOCS III grade 3 who underwent nanolaser cataract surgery...
September 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28829109/adult-orbital-and-adnexal-xanthogranulomatous-disease
#20
Michael J Davies, Kevin Whitehead, Gary Quagliotto, Dominic Wood, Rajan S Patheja, Timothy J Sullivan
PURPOSE: Adult xanthogranulomatous disease of the orbit and ocular adnexa is a rare disease that can cause serious morbidity and mortality. Ophthalmologists are commonly the first clinicians to come in contact with affected patients and an understanding of the clinical features is essential. DESIGN: We present a retrospective case series of patients seen in the oculoplastic unit of a large tertiary referral hospital over a 20-year period. METHODS: The clinical files of 7 patients with adult xanthogranulomatous disease of the orbit and ocular adnexa were reviewed...
September 2017: Asia-Pacific Journal of Ophthalmology
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