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Asia-Pacific Journal of Ophthalmology

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https://www.readbyqxmd.com/read/29280368/retinal-vein-occlusion-review
#1
Michael Ip, Andrew Hendrick
Retinal vein occlusions are a very common condition with great importance in ophthalmology clinical practice. This article reviews the salient epidemiology, risk factors, clinical features, and treatments related to retinal vein occlusions.
December 27, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29280367/intravitreal-bevacizumab-in-diabetic-retinopathy-recommendations-from-the-pan-american-collaborative-retina-study-group-pacores-the-2016-knobloch-lecture
#2
J Fernando Arevalo, T Y Alvin Liu
The advent of intravitreal anti-vascular endothelial growth factor (anti-VEGF) medications has revolutionized the treatment of diabetic eye diseases. Herein, we report the outcomes of clinical studies carried out by the Pan-American Collaborative Retina Study Group (PACORES), with a specific focus on the efficacy of intravitreal bevacizumab in the management of diabetic macular edema and proliferative diabetic retinopathy. We will also discuss the use of intravitreal bevacizumab as a preoperative, adjuvant therapy before vitrectomy for proliferative diabetic retinopathy...
December 27, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29280366/outcomes-of-infantile-onset-glaucoma-associated-with-port-wine-birthmarks-and-other-periocular-cutaneous-vascular-malformations
#3
Daniela Reyes-Capó, Kara M Cavuoto, Ta C Chang
PURPOSE: The incidence of infantile-onset secondary glaucoma associated with periocular cutaneous vascular malformations is high and the outcomes of these glaucomatous eyes have anecdotally been poor. The purpose of this study was to determine the anatomic and visual outcomes of affected eyes. DESIGN: Retrospective case series. METHODS: Consecutive patients with early-onset (younger than 36 months of age) glaucoma associated with cutaneous vascular malformations from 1995‒2015 were included...
December 27, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29280365/more-antisepsis-less-antibiotics-whenever-possible
#4
Andrzej Grzybowski, Magdalena Turczynowska
Increasing bacterial resistance to antibiotics has recently become an important medical challenge. In ophthalmology antibiotics are widely used for treatment and prophylaxis of ocular infections. In many cases antiseptics may be a valuable adjunct and sometimes even an alternative to antibiotics for the prevention and treatment of infections, reducing the overuse of antibiotics. This review aims to highlight the available literature on the subject of antibiotic resistance in ophthalmology. Full understanding of this growing problem is necessary for tailoring effective pre-, intra-, and postoperative management to improve antibiotic stewardship programs...
December 27, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29165935/peripapillary-perfused-capillary-density-in-exfoliation-syndrome-and-exfoliation-glaucoma-versus-poag-and-healthy-controls-an-octa-study
#5
Yanin Suwan, Lawrence S Geyman, Masoud Aghsaei Fard, Apichat Tantraworasin, Toco Y Chui, Richard B Rosen, Robert Ritch
PURPOSE: To compare the peripapillary perfused capillary density (PCD) among eyes with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), primary open-angle glaucoma (POAG), and controls. DESIGN: Observational, cross-sectional study. METHODS: Optical coherence tomography angiography (OCTA) images (4.5×4.5 mm) of the optic nerve head were obtained using a commercial spectral domain OCTA system (AngioVue Avanti RTVue-XR, OptoVue, Fremont, CA)...
November 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29165934/first-rapid-assessment-of-avoidable-blindness-survey-in-the-maldives-prevalence-and-causes-of-blindness-and-cataract-surgery
#6
Ubeydulla Thoufeeq, Taraprasad Das, Hans Limburg, Maharshi Maitra, Lapam Panda, Asim Sil, John Trevelyan, Yuddha Sapkota
PURPOSE: A nationwide rapid assessment of avoidable blindness survey was undertaken in the Maldives among people aged 50 years or more to assess the prevalence and causes of blindness and visual impairment, cataract surgical coverage, cataract surgery outcome, and barriers to uptake of cataract surgical services. DESIGN: Prospective population-based study. METHODS: In the cluster sampling probability proportionate to size method, 3100 participants in 62 clusters across all 20 atolls were enrolled through house-to-house visits...
November 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29082677/predictive-value-of-baseline-biochemical-parameters-for-clinical-response-of-macular-edema-to-bevacizumab-in-eyes-with-central-retinal-vein-occlusion-a-retrospective-analysis
#7
V G Madanagopalan, Bibha Kumari
PURPOSE: To evaluate the influence of baseline biochemical parameters on the improvement in best corrected visual acuity (BCVA) and reduction in central foveal thickness (CFT) in patients treated with intravitreal bevacizumab (IVB; Avastin, Genentech, Inc) for macular edema (ME) secondary to central retinal vein occlusion (CRVO). DESIGN: A retrospective study. METHODS: Seventy eyes of 70 participants with CRVO who underwent IVB for ME and had at least 1 month of follow-up after the last injection were studied...
October 30, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29204996/the-vegf-treatment-of-amd-switch-study-the-vtas-study
#8
Beverley Curry, Guy Bylsma, Alex W Hewitt, Nitin Verma
PURPOSE: To evaluate the effect of aflibercept on anatomic and visual outcomes in patients with choroidal neovascularization (CNV) previously treated with intravitreal ranibizumab with persistent fluid on optical coherence tomography (OCT). DESIGN: Prospective, open-label study. METHODS: Eighteen patients (19 eyes) with CNV being treated with monthly ranibizumab, with persistent fluid on OCT, were switched to intravitreal aflibercept injections at intervals of up to 8 weeks...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29204995/prevention-of-age-related-macular-degeneration
#9
Niharika Singh, Sangeetha Srinivasan, Vinata Muralidharan, Rupak Roy, Jayprakash V, Rajiv Raman
Age-related macular degeneration (AMD) compromises quality of life. However, the available therapeutic options are limited. This has led to the identification of modifiable risk factors to prevent the development or alter the natural course and prognosis of AMD. The identification and modification of risk factors has the potential for greater public health impact on reducing morbidity from AMD. Likewise, identifying the imaging clues and genetic clues could serve as a guide to recognizing the propensity for progression to severe and end stages of the disease...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29204994/ophthalmic-application-of-anti-vegf-therapy
#10
EDITORIAL
Timothy Y Y Lai, Chui Ming Gemmy Cheung, William F Mieler
No abstract text is available yet for this article.
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29204993/update-on-the-use-of-anti-vegf-intravitreal-therapies-for-retinal-vein-occlusions
#11
REVIEW
Yi Jiang, William F Mieler
The use of anti-vascular endothelial growth factor (VEGF) therapy in ophthalmology has profoundly changed our management and treatment of conditions such as cystoid macular edema, diabetic macular edema, choroidal neovascularization, and other proliferative retinopathies. Although initially used for the treatment of choroidal neovascularization in neovascular age-related macular degeneration, their application has spread rapidly for other indications as their outcomes have often outperformed previously existing treatments...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29204992/latest-developments-in-the-management-of-amd
#12
EDITORIAL
Andrew Chang, Patricio G Schlottmann, R V Paul Chan
No abstract text is available yet for this article.
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29076303/anti-vegf-therapy-for-diabetic-eye-diseases
#13
Bobak Bahrami, Thomas Hong, Mark C Gilles, Andrew Chang
Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness in the working-age population. The identification of vascular endothelial growth factor (VEGF) as a key mediator in the pathogenesis of DR has revolutionized the management of this vision-threatening disease. There is now strong evidence supporting intravitreal anti-VEGF therapy as first line in the management of sight-threatening diabetic macular edema (DME), along with a growing body of evidence to support the use of anti-VEGF drugs for proliferative DR...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29063741/optic-nerve-head-hemorrhages-associated-with-posterior-vitreous-detachment
#14
Philip J Polkinghorne
PURPOSE: To report and evaluate the clinical and optical coherence tomography (OCT) features of optic nerve hemorrhages (ONH) associated with spontaneous posterior vitreous detachment (PVD). DESIGN: A prospective case series conducted at a private ophthalmic practice in Auckland, New Zealand. METHODS: A consecutive series of patients presenting at a private multispecialty practice in Auckland, New Zealand, with symptoms of PVD with ONH underwent imaging of the optic nerve with digital retinal photography and OCT...
October 24, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29063740/submacular-hemorrhage-visual-outcomes-and-prognostic-factors
#15
Paradee Kunavisarut, Tipparut Thithuan, Direk Patikulsila, Janejit Choovuthayakorn, Nawat Watanachai, Voraporn Chaikitmongkol, Kessara Pathanapitoon, Aniki Rothova
PURPOSE: To describe causes, visual outcomes, and prognostic factors in patients with submacular hemorrhage (SMH). DESIGN: Retrospective case review. METHODS: We performed a retrospective review of SMH with a size of at least 1 disc diameter. SMH causes were classified into 3 groups: 1) neovascular age-related macular degeneration (nAMD), 2) polypoidal choroidal vasculopathy (PCV), and 3) other miscellaneous causes. RESULTS: Ninety-eight eyes of 98 patients were included...
October 23, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29057640/the-armour-study-anti-vegf-in-neovascular-amd-our-understanding-in-a-real-world-indian-setting
#16
Nimesh Jain, Naresh Kumar Yadav, Chaitra Jayadev, Priya Srinivasan, Ashwin Mohan, Bhujang K Shetty
PURPOSE: The aim of our study was to share our experience with anti‒vascular endothelial growth factor (anti-VEGF) injections in the treatment of neovascular age-related macular degeneration (nAMD) in a real-world setting. DESIGN: A retrospective, observational study. METHODS: Patients of Indian origin with nAMD receiving anti-VEGF with a minimum follow-up of 12 months were enrolled in this study. In group 1, patients were treated on a pro re nata (PRN) basis; in group 2, patients received a loading dose (3 injections) and were then treated on a PRN basis...
October 23, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29057641/anti-vascular-endothelial-growth-factor-therapy-for-myopic-choroidal-neovascularization
#17
Danny S C Ng, Timothy Y Y Lai, Chui Ming Gemmy Cheung, Kyoko Ohno-Matsui
Myopic choroidal neovascularization (CNV) is one of the most vision-impairing complications in patients with pathologic myopia. It is also one of the most frequently encountered non‒age-related macular degeneration causes of CNV and affects young patients in the working age group. Fluorescein angiography (FA) and spectral domain optical coherence tomography (OCT) are generally indicated to confirm the diagnosis of active myopic CNV before initiation of treatment. Without treatment, natural history studies have shown that the vision outcome can be very poor...
October 20, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971633/anti-vegf-therapy-for-neovascular-amd-and-polypoidal-choroidal-vasculopathy
#18
Gemmy Chui Ming Cheung, Timothy Y Y Lai, Fumi Gomi, Paisan Ruamviboonsuk, Adrian Koh, Won Ki Lee
Anti‒vascular endothelial growth factor (anti-VEGF) therapy has revolutionized the treatment of neovascular age-related macular degeneration (AMD). This review will summarize the current evidence of anti-VEGF therapy in neovascular AMD, including subtypes of retinal angiomatous proliferation and polypoidal choroidal vasculopathy (PCV). Importantly, 2 large multicenter randomized clinical trials evaluating the safety and efficacy of anti-VEGF monotherapy and combination with photodynamic therapy (PDT) have recently reported initial first-year outcomes...
October 3, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971631/intravitreal-ziv-aflibercept-clinical-effects-and-economic-impact
#19
Sumit Randhir Singh, Avantika Dogra, Michael Stewart, Taraprasad Das, Jay Chhablani
During the past decade, drugs that inhibit the actions of vascular endothelial growth factor (VEGF) have become standard-of-care treatment for a variety of chorioretinal vascular conditions. The off-label, intravitreal use of ziv-aflibercept (Zaltrap) has provided clinicians with an additional cost-effective drug. The commercial preparation of ziv-aflibercept contains the same aflibercept (VEGF-trap) molecule as Eylea but has a much higher osmolarity (1000 mOsm/kg vs 300 mOsm/kg). Initial concerns regarding cytotoxicity and long-term safety of intravitreal ziv-aflibercept have been largely negated after a series of publications failed to identify adverse ocular and systemic side effects...
October 3, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971630/visual-acuity-improves-in-children-and-adolescents-with-idiopathic-infantile-nystagmus
#20
Ben W R Balzer, Caroline J Catt, Milia Bou-Abdou, Frank J Martin
PURPOSE: Idiopathic infantile nystagmus is associated with reduced visual acuity. Recent work has linked extraocular muscle surgery to improvements in visual acuity through childhood but no work has reported long-term secular trends in visual acuity in infantile nystagmus. Our aim is to describe visual acuity changes for children and adolescents with idiopathic infantile nystagmus to allow comparison for future interventional studies. DESIGN: Retrospective chart review...
October 3, 2017: Asia-Pacific Journal of Ophthalmology
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