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Asia-Pacific Journal of Ophthalmology

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https://www.readbyqxmd.com/read/30387339/neurofibromatosis-type-1-review-and-update-on-emerging-therapies
#1
Tanya Karaconji, Eline Whist, Robyn V Jamieson, Maree P Flaherty, John R B Grigg
Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder affecting 1:3000 births. This familial tumor predisposition syndrome is diagnosed clinically and affects the skin, bones, and nervous system. Malignant tumors can arise in childhood or adulthood and are the commonest cause of mortality in this population. Early diagnosis and management led by a multidisciplinary team remains the standard of care, particularly in the management of optic pathway glioma. Emerging concepts in the genetic patterns of this condition have led to the introduction of new treatment modalities that target the mitogen activated protein kinase (MAPK) and the mammalian target of rapamycin (mTOR) pathways...
November 2, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30375203/plaque-radiotherapy-for-medulloepithelioma-in-6-cases-from-a-single-center
#2
Su Mae Ang, Lauren A Dalvin, Jacqueline Emrich, Lydia Komarnicky, Jerry A Shields, Carol L Shields
PURPOSE: To describe outcomes of 6 patients treated with plaque radiotherapy for medulloepithelioma. DESIGN: Retrospective review. METHODS: Computerized medical records were reviewed for cytopathologically confirmed medulloepithelioma treated with plaque radiotherapy from 1970 to 2017. Clinical and radiotherapy parameters along with outcomes of tumor regression, globe salvage, and metastatic disease were recorded. RESULTS: Of 6 patients with medulloepithelioma, plaque radiotherapy was primary (n = 5) or secondary (n = 1) treatment...
October 30, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30375202/persistent-fetal-vasculature
#3
Chonglin Chen, Hu Xiao, Xiaoyan Ding
During development, the fetal vasculature nourishes the developing lens and retina, subsequently regressing after the formation of the retinal vessels. Persistent fetal vasculature (PFV) occurs as a result of a failure of fetal ocular vasculature to undergo normal programmed involution, which leads to blindness or serious loss of vision. Persistent fetal vasculature is responsible for as much as 5% of childhood blindness in Western countries. The regulatory mechanisms responsible for fetal vascular regress remain obscure, as do the underlying causes of the failure of regression...
October 30, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30338677/controlling-progression-of-myopia-optical-and-pharmaceutical-strategies
#4
Padmaja Sankaridurg, Fabian Conrad, Huy Tran, Jianfeng Zhu
The burden associated with the rising prevalence of myopia and high myopia, and the associated vision impairment and sight-threatening complications, has triggered the need to evaluate strategies to control the progression of myopia. We provide an overview of the literature on the use of optical (spectacles, contact lenses, and orthokeratology) and pharmaceutical approaches to slow progress of myopia. The evidence indicates that myopia progression can be slowed by varying degrees using these strategies. All approaches play a role in the management of myopia as needs and requirements of an individual vary based on age, suitability, affordability, safety of the approach, subjective needs of the individual, and rate of progression...
October 19, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30338676/new-technologies-for-glaucoma-detection
#5
Ignacio Rodriguez-Una, Augusto Azuara-Blanco
This review describes some of the most relevant recent advances in the development and application of new technologies for detecting and managing glaucoma, including imaging, visual function testing, and tonometry. The widespread availability of mobile technology in the developing world is improving health care delivery, for example, with smartphones and mobile applications that allow patient data to be assessed remotely by health care providers.
October 19, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30259715/bilateral-implantation-of-a-single-piece-bifocal-diffractive-intraocular-lens-in-presbyopic-patients-a-prospective-case-series
#6
John S M Chang
PURPOSE: To report visual outcomes and quality after bilateral implantation of a single-piece diffractive multifocal intraocular lens (MIOL) with a bifocal design. DESIGN: Prospective, observational case series. METHODS: All presbyopic subjects were implanted with the ZMB00 MIOL (Abbott Medical Optics) at the Hong Kong Sanatorium and Hospital. We evaluated the distance, intermediate, and near visual acuity (VA) under photopic and mesopic conditions; contrast sensitivity with and without glare under photopic and mesopic conditions; quality of vision; and rate of spectacle independence...
September 27, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30255668/diagnosis-and-treatment-of-myopic-maculopathy
#7
Tae Yokoi, Kyoko Ohno-Matsui
Visual impairment resulting from pathological myopia is a serious issue worldwide. This is mainly due to the development of different types of myopic maculopathy. Despite being a major cause of visual impairment worldwide, myopic maculopathy was not consistently defined until 2015. To overcome this problem, the Meta-Analysis for Pathologic Myopia study group proposed a simplified, uniform classification system for myopic maculopathy. Among several lesions of myopic maculopathy, myopic choroidal neovascularization (CNV) is 1 of the most common and severe vision-threatening complications...
September 26, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30215243/simulation-in-ophthalmic-training
#8
Judith L Flanagan, Neilsen De Souza
Vision impairment and blindness arise both as a cause, and a consequence, of poverty. Achievement of the United Nations Sustainable Development Goals in providing universal access and equity in eye care, both within and between among countries, remains challenging. A severe shortage of eye care providers is creating unnecessary blindness and vision impairment in developing communities worldwide. Education and training develops and strengthens the capacity of emerging nations to contribute to global eye health and the World Health Organization Development Goals in an effective and sustainable way...
September 14, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30188025/asia-pacific-technology-and-trend-survey-2016-2017
#9
Jay Chhablani, Adnan Shaikh, Abhilash Goud, Ryo Kawasaki, Oh W Kwon, Andrew Chang, Dennis Lam, Taraprasad Das
PURPOSE: To report the results of a survey conducted among retina specialists in the Asia-Pacific region on real-life practice patterns in the management of vitreoretinal diseases. DESIGN: Prospective study. METHODS: In 2016 and 2017, a link was sent to 1400 retinal specialists across the Asia-Pacific region by e-mail, which directed to a web-based questionnaire (Google forms or Survey Monkey) with secure confidential access. The study had institutional review board approval...
September 6, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30311753/corrigendum-differences-between-single-and-double-eyelid-anatomy-in-asians-using-ultrasound-biomicroscopy
#10
Preamjit Saonanon, Penake Thongtong, Tee Wongwuticomjon
This corrects the article DOI: 10.1097/APO.0000000000000185.
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30311470/corrigendum-pharmacotherapy-and-rop-going-back-to-the-basics
#11
Julia P Shulman, M Elizabeth Hartnett
This corrects the article DOI: 10.22608/APO.201853.
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30264551/advanced-subconjunctival-anesthesia-for-cataract-surgery
#12
Sharnie Wu, Kong Chan Tang
PURPOSE: Ocular regional blocks generally require blind instrumentation to the posterior orbit, leading to rare but serious complications. However, topical anesthesia does not suppress eye or lid movements and may lead to more surgical complications. Advanced subconjunctival anesthesia (ASCAN) is a technique developed to provide reliable akinesia and anesthesia without anterior dissection or blind intrusion into the posterior orbit, while allowing visualization of the needle-tip position...
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30255669/non-self-sealing-leaky-anterior-chamber-paracentesis-a-new-technique-in-managing-postphacoemulsification-intraocular-pressure-rise-in-glaucoma-and-normal-eyes
#13
Dennis Lam, Jacky Lee, Enne Leung, Shirley Liu, Julianna Yuan, Vineet Ratra
Phacoemulsification (phaco) for cataract extraction is 1 of the most commonly performed ophthalmic surgeries. With increasing evidence of significant intraocular pressure (IOP) reduction after phaco, the paradigm for glaucoma treatment has been shifting toward more cataract extraction instead of glaucoma surgery; thus, the population of glaucoma patients undergoing phaco is likely to continue to increase in the coming years. Although the safety of surgery has improved over the years with newer technologies and machines, postoperative IOP spike remains an important condition even after an uneventful operation...
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30221499/glaucoma-drugs-in-the-pipeline
#14
REVIEW
Paul L Kaufman, Mary E Mohr, Scott P Riccomini, Carol A Rasmussen
Glaucoma is a chronic disease that can be challenging to treat for both patients and physicians. Most patients will require more than 1 medication over time to maintain their intraocular pressure (IOP) at a physiologically benign level. Patients may become refractory to existing compounds and many struggle with adherence to multiple topical drop regimens. The field of glaucoma therapeutics has been advancing rapidly with an emphasis on compounds comprising multiple molecules/mechanisms of action that offer additivity and are complementary to current therapeutics...
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30207131/rapid-assessment-of-avoidable-blindness-past-present-and-future
#15
EDITORIAL
Ivo Kocur, Hans Limburg, Serge Resnikoff
No abstract text is available yet for this article.
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30074308/anophthalmic-sockets-in-retinoblastoma-a-single-center-experience
#16
Preethi Jeyabal, Gangadhara Sundar
PURPOSE: To evaluate outcomes of anophthalmic sockets in retinoblastoma at a tertiary care center in Singapore. DESIGN: A retrospective study. METHODS: Patients who underwent enucleation as sole/part of treatment for retinoblastoma were reviewed at our center from 2005-2017. Details including demographics, grouping and staging, adjuvant therapy, surgery, implant, and complications were collected. RESULTS: Of 42 patients with retinoblastoma managed over the period, the anophthalmic sockets of 31 patients who underwent enucleation were analyzed...
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/30043556/does-nd-yag-capsulotomy-increase-the-risk-of-retinal-detachment
#17
REVIEW
Andrzej Grzybowski, Piotr Kanclerz
Laser capsulotomy is accepted as a standard and effective treatment for posterior capsule opacification. It is generally believed that neodymium:YAG (Nd:YAG) capsulotomy is related to an increased risk of retinal detachment (RD). The aim of this study was to evaluate the association between Nd:YAG capsulotomy and risk for developing RD. A PubMed and Medline search was conducted using the terms "retinal detachment" and "Nd:YAG laser capsulotomy." Of the articles retrieved by this method, all publications in English and abstracts of non-English publications were reviewed...
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29993202/sustainability-of-pain-relief-after-corneal-collagen-cross-linking-in-eyes-with-bullous-keratopathy
#18
Takashi Ono, Yosai Mori, Ryohei Nejima, Miyuki Ogata, Keiichiro Minami, Kazunori Miyata
PURPOSE: This study aimed to examine the efficiency and sustainability of pain relief produced by corneal collagen cross-linking (CXL) in eyes with bullous keratopathy (BK) and to explore the histopathological changes in the stroma by using in vivo confocal microscopy. DESIGN: Prospective observational case series. METHODS: Fourteen eyes of 14 consecutive BK patients were treated with CXL with dehydration of the corneal stroma and followed up for 1 year after treatment...
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29984563/leaving-no-one-behind-strengthening-access-to-eye-health-programs-for-people-with-disabilities-in-6-low-and-middle-income-countries
#19
Manfred Mörchen, Asahel Bush, Petra Kiel, David Lewis, Babar Qureshi
PURPOSE: To assess the impact of inclusive eye health programs for people with disabilities. DESIGN: A synthesis evaluation study. METHODS: A cross-disciplinary team of ophthalmologists, evaluation, and disability-inclusive development advisors purposively selected evaluation reports of CBM-supported inclusive eye health programs in low- and middle-income countries. Employing a change-promoting paradigm, salient achievements and challenges were narratively analyzed and recommendations suggested based on a previously developed framework for strengthening disability inclusion in eye health programs...
September 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29984562/optical-coherence-tomography-of-small-retinoblastoma
#20
R Joel Welch, Raksha Rao, Phillip S Gordon, Emil Anthony T Say, Carol L Shields
PURPOSE: To investigate hand-held optical coherence tomography (HH-OCT) characteristics of small (<1 mm thickness) retinoblastoma. DESIGN: Retrospective observational case series. METHODS: Patient and tumor data were extracted from the medical record and analyzed along with HH-OCT scans. Determination of tumor layer of origin was performed using a layer-by-layer analysis of HH-OCT data and specific HH-OCT-related features were described...
September 2018: Asia-Pacific Journal of Ophthalmology
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