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Asia-Pacific Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28436640/intravitreal-aflibercept-for-patients-with-diabetic-macular-edema-refractory-to-bevacizumab-or-ranibizumab-analysis-of-response-to-aflibercept
#1
Yen-Yi Chen, Pei-Yao Chang, Jia-Kang Wang
PURPOSE: To investigate the short-term efficacy and safety of intravitreal aflibercept in a case series of patients with diabetic macular edema (DME) refractory to ranibizumab or bevacizumab. DESIGN: A retrospective chart review. METHODS: From September 2013 to March 2016, we identified patients with DME who developed resistance to bevacizumab or ranibizumab. Three monthly intravitreal aflibercept injections were administered in refractory cases...
April 10, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379656/barriers-to-the-uptake-of-cataract-surgery-and-eye-care-after-community-outreach-screening-in-takeo-province-cambodia
#2
Gail M Ormsby, Manfred Mörchen, Kathy Fotis, Dawn Grant Skiba, Channeang Chim, Jill E Keeffe
PURPOSE: To assess the barriers influencing eye healthcare seeking behavior after community outreach screening. DESIGN: A concurrent mixed methods study. METHODS: A total of 469 patients screened during the previous 12 months were followed up, of which 354 (75%) from 5 districts were interviewed in person, using a semi-structured questionnaire, in-depth interviews (n = 11), and 16 focus groups (n = 71). SPSS and NVivo were used to analyze response frequency and identify themes...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379655/recommended-guidelines-for-use-of-intravitreal-aflibercept-with-a-treat-and-extend-regimen-for-the-management-of-neovascular-age-related-macular-degeneration-in-the-asia-pacific-region-report-from-a-consensus-panel
#3
Adrian Koh, Paolo Lanzetta, Won Ki Lee, Chi-Chun Lai, Wai-Man Chan, Chung-May Yang, Chui Ming Gemmy Cheung
PURPOSE: To summarize recommendations for the use of intravitreal aflibercept with a treat-and-extend regimen to manage neovascular age-related macular degeneration (nAMD) in the Asia-Pacific region. Although anti-vascular endothelial growth factor therapies have improved the quality of life of patients with nAMD, a leading cause of blindness and visual impairment, the high treatment frequency recommended by current guidelines places a significant burden on patients and healthcare providers...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379654/corneal-collagen-crosslinking-for-post-lasik-ectasia-an-australian-study
#4
Jessica Y Tong, Deepa Viswanathan, Christopher Hodge, Gerard Sutton, Colin Chan, John J Males
PURPOSE: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting. DESIGN: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379653/factors-related-to-prostaglandin-associated-periorbitopathy-in-glaucoma-patients
#5
Chanikarn Patradul, Visanee Tantisevi, Anita Manassakorn
PURPOSE: To determine factors related to prostaglandin-associated periorbitopathy (PAP) and its prevalence in glaucoma or ocular hypertension (OHT) patients using prostaglandins analogs (PGAs). DESIGN: A cross-sectional study. METHODS: A study of glaucoma or OHT patients, using topical PGAs for at least 3 months, was performed. Eyes treated with PGAs were photoraphed and independently evaluated for PAP by 2 glaucoma specialists using at least 4 out of 7 clinical appearances...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379652/quantitative-reduction-in-central-foveal-thickness-after-first-anti-vegf-injection-as-a-predictor-of-final-outcome-in-brvo-patients
#6
Rupak Roy, Kumar Saurabh, Avirupa Ghose, Dhileesh P Chandrasekharan, Preeti Sharma, Swakshyar Saumya Pal, Sudipta Das
PURPOSE: To analyze the predictive ability of quantitative reduction in central foveal thickness (CFT) after the first antivascular endothelial growth factor (anti-VEGF) injection to assess final outcome in branch retinal vein occlusion (BRVO) patients. DESIGN: A retrospective interventional consecutive case series. METHODS: We retrospectively reviewed 60 treatment-naive BRVO patients. All the patients were treated with bevacizumab injection pro re nata...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379651/visual-quality-after-femtosecond-laser-small-incision-lenticule-extraction
#7
Huamao Miao, Tian Han, Mi Tian, Xiaoying Wang, Xingtao Zhou
Femtosecond laser small incision lenticule extraction (SMILE) is a newly developed form of "flapless" corneal refractive surgery with all-in-one technology. Femtosecond laser SMILE is increasingly attractive for both doctors and patients because it is minimally invasive and does not require a flap to be lifted during surgery. It exhibits many advantages in terms of morphology, biomechanical effects, corneal wound healing, and nerve rehabilitation. However, visual quality assessment after refractive surgeries is just as important as these advantages and correlates with patient satisfaction...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379650/the-effect-of-eye-patching-on-clear-corneal-incision-architecture-in-phacoemulsification-a-randomized-controlled-trial
#8
Fui Li Ho, Mohamad Aziz Salowi, Mae-Lynn Catherine Bastion
PURPOSE: To investigate the effects of postoperative eye patching on clear corneal incision architecture in phacoemulsification. DESIGN: A single-center, randomized controlled trial. METHODS: A total of 132 patients with uncomplicated phacoemulsification were randomly allocated to the intervention or control group. The intervention group received postoperative eye patching for approximately 18 hours, whereas the control group received eye shield...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379649/grafts-in-glaucoma-surgery-a-review-of-the-literature
#9
Sahil Thakur, Parul Ichhpujani, Suresh Kumar
Patients with bleb leakage, dehiscence, or infection after trabeculectomy need urgent bleb salvaging to prevent vision loss. Patients who have undergone a glaucoma drainage device surgery may have tube erosion, which is yet another devastating and outcome-compromising complication. The bleb or the tube in such cases needs to be patched by a biologic tissue, which is roofed by the conjunctiva and acts as a barrier against external infections. Sclera, pericardium, cornea, and dura mater are the commonly used patch graft materials...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379648/cap-lenticular-adhesion-during-small-incision-lenticular-extraction-surgery-causative-factors-and-outcomes
#10
Rohit Shetty, Nikhil Negalur, Rushad Shroff, Kalyani Deshpande, Chaitra Jayadev
PURPOSE: To study the factors causing cap lenticular adhesion (CLA), a rare complication of small incision lenticule extraction (SMILE) surgery, and its effect on surgical outcomes. DESIGN: A prospective, observational, cross-sectional study involving 550 eyes of 285 subjects. METHODS: SMILE was performed using the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) with a minimum of 3 months follow-up. Preoperative visual quality assessment, measurement of corneal biomechanics, and Bowman membrane imaging were performed...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379647/awareness-and-knowledge-of-glaucoma-in-central-india-a-hospital-based-study
#11
Prafulla K Maharana, Vaishali G Rai, Rajesh Pattebahadur, Shipra Singhi, Ashish K Chauhan
PURPOSE: To assess the awareness and knowledge of glaucoma among people attending the ophthalmology outpatient department at a tertiary care hospital in central India. DESIGN: A prospective observational study. METHODS: A questionnaire-based study was conducted, involving persons aged 18 and above attending the ophthalmology outpatient department from October 2014 to September 2015. Data on awareness and knowledge of glaucoma was collected through a face-to-face interview...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399347/conjunctival-tumors-review-of-clinical-features-risks-biomarkers-and-outcomes-the-2017-j-donald-m-gass-lecture
#12
Carol L Shields, Jason L Chien, Thamolwan Surakiatchanukul, Kareem Sioufi, Sara E Lally, Jerry A Shields
Conjunctival tumors encompass a broad range of diagnoses. The 3 most important malignant tumors include ocular surface squamous neoplasia (OSSN) (14%), melanoma (12%), and lymphoma (7%). Conjunctival malignancies are rarely found in children. Regarding OSSN, pre-disposing conditions include chronic solar radiation, immune deficiency (HIV), organ transplant, autoimmune conditions, xeroderma pigmentosum, and chronic exposure to cigarette smoke. OSSN is managed surgically or with topical/injection immunotherapy or chemotherapy...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399346/tumors-and-related-lesions-of-the-pigmented-epithelium
#13
Jerry A Shields, Carol L Shields
Several tumors and pseudotumors can arise from the iris pigment epithelium (IPE), ciliary pigment epithelium (CPE), and retinal pigment epithelium (RPE), including cysts of the IPE, solitary congenital hypertrophy of the RPE (CHRPE), multifocal CHRPE ("bear tracks"), congenital simple hamartoma of the RPE, combined hamartoma of the retina and RPE, and acquired epithelioma of IPE, CPE, and RPE. This article describes examples of pigment epithelial tumors and pseudotumors by reviewing the literature and cases on file in the Oncology Service at Wills Eye Hospital...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399345/intraocular-metastases-a-review
#14
Lazaros Konstantinidis, Bertil Damato
Intraocular metastases almost invariably arise in the uveal tract, mostly in the posterior choroid. They are the most common type of intraocular malignancy and often the first sign of tumor dissemination. Choroidal metastases generally appear as a creamy white or pale yellow mass associated with subretinal fluid and may be multifocal and bilateral. The most common primary sites are breast and lung. Diagnosis is aided by a variety of tests, particularly ultrasonography and optical coherence tomography. Intraocular biopsy is useful in patients with clinical suspicion of uveal metastasis but no evidence of primary malignancy despite systemic evaluation...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399344/the-development-of-ocular-oncology-watching-a-dream-come-true
#15
EDITORIAL
Jerry A Shields, Carol L Shields
No abstract text is available yet for this article.
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399343/pharmacotherapy-and-immunotherapy-of-conjunctival-tumors
#16
Edoardo Midena, Luisa Frizziero, Raffaele Parrozzani
Conjunctiva and cornea tumors represent a large spectrum of conditions ranging from benign lesions to aggressive and life-threatening malignancies. Topical pharmacotherapies and immunotherapies have recently acquired a relevant role in the management of conjunctival tumors and, in the past 2 decades, there has been a shift from surgery alone toward the use of these agents, both as a sole therapy or as adjunct to surgery (before or after surgery). The 3 main agents that have been used for topical medical treatment of conjunctival tumors are mitomycin-C, 5-fluorouracil, and interferon-α2b...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399342/uveal-melanoma-treatment-and-prognostication
#17
Mehmet Dogrusöz, Martine J Jager, Bertil Damato
Approximately 90% of uveal melanoma develop in the choroid, with the remainder arising in the ciliary body or the iris. The treatment of uveal melanoma is aimed at conserving the eye and useful vision, and, if possible, preventing metastatic disease. Enucleation is now reserved for tumors that are large and/or involve the optic disc, having largely been replaced by various forms of radiotherapy (plaque brachy-therapy, proton beam or stereotactic radiotherapy) and laser therapy. Whereas iridectomy and iridocyclectomy are widely performed, transscleral exoresection of choroidal tumors is performed only in a few centers because it requires special skills and hypotensive anesthesia...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399341/lymphoproliferative-tumors-of-the-ocular-adnexa
#18
Robert M Verdijk
The ocular adnexa include the eyelids, conjunctiva, lacrimal apparatus, and orbital soft tissue. One percent of all lymphomas and approximately 8% of all extranodal lymphomas arise in the ocular adnexa and their incidence is increasing. Reactive lymphoid hyperplasia comprises 16% of all lymphoproliferative tumors of the ocular adnexa. The relative frequencies of ocular adnexal lymphoma presentation are in the orbit, 37%; conjunctiva, 29%; lacrimal apparatus, 20%; and eyelid, 14%. The most frequent primary lymphoma types of the ocular adnexa are extranodal marginal zone lymphoma, 62%; follicular lymphoma, 17%; and diffuse large B-cell lymphoma, 10%...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399340/what-s-new-in-eyelid-tumors
#19
Nora Silverman, Roman Shinder
Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Given the constraints of the anatomy and function of the eyelids, excision with negative margins and reconstruction can be challenging. In cases of significant tissue invasion or metastasis, complete tumor removal may not be possible...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399339/uveal-melanoma-identifying-immunological-and-chemotherapeutic-targets-to-treat-metastases
#20
Martine J Jager, Mehmet Dogrusöz, Scott E Woodman
Uveal melanoma is an intraocular malignancy that, depending on its size and genetic make-up, may lead to metastases in up to 50% of cases. Currently, no therapy has been proven to improve survival. However, new therapies exploiting immune responses against metastases are being developed. The primary tumor is well characterized: tumors at high risk of developing metastases often contain macrophages and lymphocytes. However, these lymphocytes are often regulatory T cells that may suppress immune response. Currently, immune checkpoint inhibitors have shown marked efficacy in multiple cancers (eg, cutaneous melanoma) but do not yet improve survival in uveal melanoma patients...
March 2017: Asia-Pacific Journal of Ophthalmology
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