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Asia-Pacific Journal of Ophthalmology

Jasmine H Francis, Ariana M Levin, David H Abramson
PURPOSE: The aim of this study was to review peer-reviewed articles on ophthalmic oncology (specifically retinoblastoma and uveal melanoma) published from January to December 2014. DESIGN: This study is a literature review. METHODS: The terms retinoblastoma and uveal melanoma were used in a MEDLINE literature search. Abstracts were studied, and the most relevant articles were selected for inclusion and further in-depth review. RESULTS: In retinoblastoma, more eyes are being salvaged due to intravitreal melphalan...
September 2016: Asia-Pacific Journal of Ophthalmology
Surabhi Ruia, Sandeep Saxena, Chui Ming Gemmy Cheung, Jagjit S Gilhotra, Timothy Y Y Lai
Spectral domain optical coherence tomography (SD-OCT) is fast becoming the current standard of care for the detection and assessment of diabetic macular edema. With the application of SD-OCT for imaging of retinal microstructure and measurement of retinal thickness, new information regarding disease characteristics has been gathered, which was unrecognized previously. Retinal thickness measurements on SD-OCT have also been used for deciding the management and monitoring of the disease. Since its development, OCT has enhanced the understanding of retinal anatomical changes in diabetic retinopathy...
September 2016: Asia-Pacific Journal of Ophthalmology
Suber S Huang, Chad Marcantonio
No abstract text is available yet for this article.
September 2016: Asia-Pacific Journal of Ophthalmology
Gail Melva Ormsby, Dawn Grant-Skiba, Kovin Naidoo, Jill E Keeffe
PURPOSE: To assess the perspectives of patients who acquired spectacles from an eye unit/vision center in Cambodia. DESIGN: A sample (n = 62) of patients was selected across 4 provinces: Prey Veng, Siem Reap, Battambang, and Takeo. METHODS: The Patient Spectacle Satisfaction Survey covering demographic and semistructured questions regarding patient satisfaction, style, and costs incurred was used to collect data. Information was transcribed and translated into English and analyzed by thematic coding using NVivo...
September 2016: Asia-Pacific Journal of Ophthalmology
Kirthi Kumar Naidu Sugnanam, Shirley Ma, Andreas Kreis, Marcelino Correia, Nitin Verma, Mohamed Dirani
PURPOSE: This study aimed to present the methodology of the East Timor Eye Program and report the prevalence of eye disease seen at the National Eye Centre during a 3-month sample period between June and August 2012. DESIGN: Two hundred ninety-three new patients aged 17 years or older were assessed at the National Eye Centre in Dili, Timor-Leste. METHODS: All participants received a comprehensive dilated eye examination that included distance visual acuity measurements, indirect fundoscopy, and a complete slit lamp assessment including gonioscopy and intraocular pressure measurement...
September 2016: Asia-Pacific Journal of Ophthalmology
Amrita Verma, Manish Nagpal, Navneet Mehrotra
PURPOSE: The aim of this study was to measure the largest hyporeflective (LHR) lumen in the choroid and subfoveal choroidal thickness (SFCT) in patients with diabetic retinopathy (DR) and in control subjects using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). DESIGN: This was a prospective, cross-sectional study. METHODS: This was a study of 240 eyes of DR patients (n = 120) and control subjects (n = 120) matched for age, sex, and refractive error...
September 2016: Asia-Pacific Journal of Ophthalmology
Jaya Gupta, Shiva Prasad Gantyala, Seema Kashyap, Radhika Tandon
PURPOSE: Corneal keloids are rare lesions that develop in cases of corneal insult. We describe the clinical features, subsequent management, and histopathological characteristics of 5 of our cases of corneal keloid. DESIGN: This was an interventional case series. METHODS: A total of 5 patients were examined and treated for corneal keloid. RESULTS: Five Indian patients with no keloids on the skin or any history of hypertrophic scar formation complained of progressive painless dimness of vision and a slowly growing epicorneal mass...
September 2016: Asia-Pacific Journal of Ophthalmology
Rahul Bhargava, Prachi Kumar, Shiv Kumar Sharma, Yogesh Arora
PURPOSE: To compare the safety and efficacy of phacoemulsification and manual small incision cataract surgery (SICS) to treat cataract in patients with Fuchs heterochromic iridocyclitis (FHI). DESIGN: A randomized, double-masked, prospective, multicenter study. METHODS: Consecutive patients with cataract after FHI were randomly assigned to have phacoemulsification or manual SICS by 1 of 2 surgeons experienced in both techniques. Complications (intraoperatively and postoperatively), operative time, visual acuities, endothelial cell counts, and surgically induced astigmatism were compared...
September 2016: Asia-Pacific Journal of Ophthalmology
Sailaja Bondalapati, Subhadra Jalali, Jay Chhablani
PURPOSE: This study aimed to report the outcomes of antivascular endothelial growth factor (anti-VEGF) monotherapy for choroidal neovascularization (CNVM) associated with retinochoroidal coloboma (RCC). DESIGN: A retrospective case series. METHODS: This was a case series of 3 eyes with CNVM associated with RCC that presented to the LV Prasad Eye Institute, Hyderabad, India, between January 2006 and January 2014. Reported data included demographics, preoperative details (symptoms, duration of symptoms, and visual acuity), treatment methods, and postoperative details (visual acuity, follow-up, and recurrence)...
September 2016: Asia-Pacific Journal of Ophthalmology
Preamjit Saonanon, Penake Thongtong, Tee Wongwuticomjon
PURPOSE: The aim of this study was to clarify the differences between single and double eyelid structures quantitatively using an ultrasound biomicroscopy. DESIGN: A single-center observational study. METHODS: Upper eyelids of Asian volunteers were evaluated with a 50-MHz ultrasound biomicroscopy. The skin-orbicularis oculi complex (SOOC), levator aponeurosis, Mueller muscle-conjunctival complex, and tarsus were imaged at the eyelid crease in the double eyelid group and 7 mm above the eyelid margin in the single eyelid group...
September 2016: Asia-Pacific Journal of Ophthalmology
Pui Yee Sin, David Ta Li Liu, Alvin L Young
PURPOSE: Posterior scleritis is a potentially blinding ocular disorder that is often difficult to diagnose because of the low incidence and varied clinical presentation. Nodular posterior scleritis can mimic a choroidal mass and pose diagnostic difficulties to clinicians. This case report and literature review aimed to evaluate the clinical presentation of nodular posterior scleritis that mimics choroidal tumor, along with the etiologies, treatment modalities, and outcomes. DESIGN: Case report and literature review...
September 2016: Asia-Pacific Journal of Ophthalmology
Keryn A Williams, Yazad D Irani
Despite ever-increasing understanding of the genetic underpinnings of many corneal dystrophies, gene therapy designed to ameliorate disease has not yet been reported in any human patient. In this review, we explore the likely reasons for this apparent failure of translation. We identify the requirements for success: the genetic defect involved must have been identified and mapped, vision in the affected patient must be significantly impaired or likely to be impaired, no better or equivalently effective treatment must be available, the treatment must be capable of modulating corneal pathology, and delivery of the construct to the appropriate cell must be practicable...
July 2016: Asia-Pacific Journal of Ophthalmology
Robin H Schmidt, John M Nickerson, Jeffrey H Boatright
DNA damage is a common feature of neurodegenerative illnesses, and the ability to repair DNA strand breaks and lesions is crucial for neuronal survival, reported by Jeppesen et al (Prog Neurobiol. 2011;94:166-200) and Shiwaku et al (Curr Mol Med. 2015;15:119-128). Interventions aimed at repairing these lesions, therefore, could be useful for preventing or delaying the progression of disease. One potential strategy for promoting DNA damage repair (DDR) is exercise. Although the role of exercise in DDR is not understood, there is increasing evidence that simple physical activity may impact clinical outcomes for neurodegeneration...
July 2016: Asia-Pacific Journal of Ophthalmology
Micah A Chrenek, John M Nickerson, Jeffrey H Boatright
Ophthalmic researchers and clinicians arguably have led the way for safe, effective gene therapy, most notably with adeno-associated viral gene supplementation in the treatment for patients with Leber congenital amaurosis type 2 with mutations in the RPE65 gene. These successes notwithstanding, most other genetic retinal disease will be refractory to supplementation. The ideal gene therapy approach would correct gene mutations to restore normal function in the affected cells. Gene editing in which a mutant allele is inactivated or converted to sequence that restores normal function is hypothetically one such approach...
July 2016: Asia-Pacific Journal of Ophthalmology
Ian Jeffery Constable, Mark Scott Blumenkranz, Steven D Schwartz, Sam Barone, Chooi-May Lai, Elizabeth Piroska Rakoczy
The purpose of this article was to evaluate safety and signals of efficacy of gene therapy with subretinal rAAV.sFlt-1 for wet age-related macular degeneration (wet AMD). A phase 1 dose-escalating single-center controlled unmasked human clinical trial was followed up by extension of the protocol to a phase 2A single-center trial. rAAV.sFlt-1 vector was used to deliver a naturally occurring anti-vascular endothelial growth factor agent, sFlt-1, into the subretinal space. In phase 1, step 1 randomized 3 subjects to low-dose rAAV...
July 2016: Asia-Pacific Journal of Ophthalmology
Sundar Srilekha, Bhavna Rao, Divya M Rao, D Sudha, Sathya Priya Chandrasekar, A J Pandian, N Soumittra, S Sripriya
Gene mapping of inherited ophthalmic diseases such as congenital cataracts, retinal degeneration, glaucoma, age-related macular degeneration, myopia, optic atrophy, and eye malformations has shed more light on the disease pathology, identified targets for research on therapeutics, earlier detection, and treatment options for disease management and patient care. This article details the different approaches to gene identification for both Mendelian and complex eye disorders.
July 2016: Asia-Pacific Journal of Ophthalmology
Qingjiong Zhang
Retinitis pigmentosa is the most common form of hereditary retinal degeneration causing blindness. Great progress has been made in the identification of the causative genes. Gene diagnosis will soon become an affordable routine clinical test because of the wide application of next-generation sequencing. Gene-based therapy provides hope for curing the disease. Investigation into the molecular pathways from mutation to rod cell death may reveal targets for developing new treatment. Related progress with existing systematic review is briefly summarized so that readers may find the relevant references for in-depth reading...
July 2016: Asia-Pacific Journal of Ophthalmology
Ashwin Mallipatna, Meghan Marino, Arun D Singh
Retinoblastoma is a malignant retinal tumor that affects young children. Mutations in the RB1 gene cause retinoblastoma. Mutations in both RB1 alleles within the precursor retinal cell are essential, with one mutation that may be germline or somatic and the second one that is always somatic. Identification of the RB1 germline status of a patient allows differentiation between sporadic and heritable retinoblastoma variants. Application of this knowledge is crucial for assessing short-term (risk of additional tumors in the same eye and other eye) and long-term (risk of nonocular malignant tumors) prognosis and offering cost-effective surveillance strategies...
July 2016: Asia-Pacific Journal of Ophthalmology
Tin Aung, Chiea Chuen Khor
Once considered primarily a disease of aging caused by unknown environmental influences, the notion that heritable factors could significantly contribute to the pathogenesis of sporadic glaucoma has rapidly gained traction. In part, this is due to the rapid and definitive identification of genes with strong effects on familial, earlier onset forms of glaucoma. Although the endpoint of glaucoma is irreversible optic nerve damage accompanied by blindness, the initial inciting trigger could differ. To this end, well-powered genome-wide association studies have each been conducted for primary open-angle glaucoma, primary angle-closure glaucoma, along with exfoliation syndrome and glaucoma...
July 2016: Asia-Pacific Journal of Ophthalmology
David A Mackey, Lisa S Kearns, Alex W Hewitt
Leber hereditary optic neuropathy has now joined Leber congenital amaurosis in the list of genetic eye diseases undergoing gene therapy clinical trials. Although a dramatic response to treatment would be welcome, a minor improvement in vision is a major challenge in efficacy assessment, given this may occur spontaneously as part of the natural history of minor recovery in some patients. Thus, we must await the outcome of adequately powered clinical trials to know if the treatment is effective, particularly given the likely high cost of such therapeutic interventions in the future...
July 2016: Asia-Pacific Journal of Ophthalmology
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