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Asia-Pacific Journal of Ophthalmology

Paul L Kaufman, Mary E Mohr, Scott P Riccomini, Carol A Rasmussen
Glaucoma is a chronic disease that can be challenging to treat for both patients and physicians. Most patients will require more than 1 medication over time to maintain their intraocular pressure (IOP) at a physiologically benign level. Patients may become refractory to existing compounds and many struggle with adherence to multiple topical drop regimens. The field of glaucoma therapeutics has been advancing rapidly with an emphasis on compounds comprising multiple molecules/mechanisms of action that offer additivity and are complementary to current therapeutics...
September 17, 2018: Asia-Pacific Journal of Ophthalmology
Judith L Flanagan, Neilsen De Souza
Vision impairment and blindness arise both as a cause, and a consequence, of poverty. Achievement of the United Nations Sustainable Development Goals in providing universal access and equity in eye care, both within and between among countries, remains challenging. A severe shortage of eye care providers is creating unnecessary blindness and vision impairment in developing communities worldwide. Education and training develops and strengthens the capacity of emerging nations to contribute to global eye health and the World Health Organization Development Goals in an effective and sustainable way...
September 14, 2018: Asia-Pacific Journal of Ophthalmology
Ivo Kocur, Hans Limburg, Serge Resnikoff
No abstract text is available yet for this article.
September 12, 2018: Asia-Pacific Journal of Ophthalmology
Jay Chhablani, Adnan Shaikh, Abhilash Goud, Ryo Kawasaki, Oh W Kwon, Andrew Chang, Dennis Lam, Taraprasad Das
PURPOSE: To report the results of a survey conducted among retina specialists in the Asia-Pacific region on real-life practice patterns in the management of vitreoretinal diseases. DESIGN: Prospective study. METHODS: In 2016 and 2017, a link was sent to 1400 retinal specialists across the Asia-Pacific region by e-mail, which directed to a web-based questionnaire (Google forms or Survey Monkey) with secure confidential access. The study had institutional review board approval...
September 6, 2018: Asia-Pacific Journal of Ophthalmology
Preethi Jeyabal, Gangadhara Sundar
PURPOSE: To evaluate outcomes of anophthalmic sockets in retinoblastoma at a tertiary care center in Singapore. DESIGN: A retrospective study. METHODS: Patients who underwent enucleation as sole/part of treatment for retinoblastoma were reviewed at our center from 2005-2017. Details including demographics, grouping and staging, adjuvant therapy, surgery, implant, and complications were collected. RESULTS: Of 42 patients with retinoblastoma managed over the period, the anophthalmic sockets of 31 patients who underwent enucleation were analyzed...
August 3, 2018: Asia-Pacific Journal of Ophthalmology
Stephen Stewart, Noemi Lois
Fenofibrate is a safe and inexpensive orally administered fibric acid derivative conventionally used to treat dyslipidemia. Two large randomized clinical trials, the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) and the Action to Control Cardiovascular Risk in Diabetes (ACCORD) studies, demonstrated the benefit of oral fenofibrate in the treatment of people with type 2 diabetes and diabetic retinopathy (DR), including reduced disease progression and need for laser treatment for diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR)...
July 30, 2018: Asia-Pacific Journal of Ophthalmology
Vivek Pravin Dave, Avinash Pathengay, Jill Keeffe, Catherine Green
PURPOSE: To describe the concept and report the uptake of Just-A-Minute (JAM) clinical pearls, a novel tele-ophthalmology educational tool. DESIGN: Analysis of a survey conducted among the recipients of JAM clinical pearls. METHODS: One clinical pearl was disseminated daily to all ophthalmologists in the email database of L V Prasad Eye Institute from August 2016 to September 2017. A survey was circulated to the recipients and their responses were recorded and analyzed to evaluate the JAM pearls regarding qualification of the recipients, type of practice, regularity of accessing the pearls, type of pearl most sought, clarity of content, applicability to the clinic, relevance to practice, satisfaction with the format, and likelihood of recommendation...
July 25, 2018: Asia-Pacific Journal of Ophthalmology
Andrzej Grzybowski, Piotr Kanclerz
Laser capsulotomy is accepted as a standard and effective treatment for posterior capsule opacification. It is generally believed that neodymium:YAG (Nd:YAG) capsulotomy is related to an increased risk of retinal detachment (RD). The aim of this study was to evaluate the association between Nd:YAG capsulotomy and risk for developing RD. A PubMed and Medline search was conducted using the terms "retinal detachment" and "Nd:YAG laser capsulotomy." Of the articles retrieved by this method, all publications in English and abstracts of non-English publications were reviewed...
July 24, 2018: Asia-Pacific Journal of Ophthalmology
Takashi Ono, Yosai Mori, Ryohei Nejima, Miyuki Ogata, Keiichiro Minami, Kazunori Miyata
PURPOSE: This study aimed to examine the efficiency and sustainability of pain relief produced by corneal collagen cross-linking (CXL) in eyes with bullous keratopathy (BK) and to explore the histopathological changes in the stroma by using in vivo confocal microscopy. DESIGN: Prospective observational case series. METHODS: Fourteen eyes of 14 consecutive BK patients were treated with CXL with dehydration of the corneal stroma and followed up for 1 year after treatment...
July 11, 2018: Asia-Pacific Journal of Ophthalmology
Manfred Mörchen, Asahel Bush, Petra Kiel, David Lewis, Babar Qureshi
PURPOSE: To assess the impact of inclusive eye health programs for people with disabilities. DESIGN: A synthesis evaluation study. METHODS: A cross-disciplinary team of ophthalmologists, evaluation, and disability-inclusive development advisors purposively selected evaluation reports of CBM-supported inclusive eye health programs in low- and middle-income countries. Employing a change-promoting paradigm, salient achievements and challenges were narratively analyzed and recommendations suggested based on a previously developed framework for strengthening disability inclusion in eye health programs...
July 9, 2018: Asia-Pacific Journal of Ophthalmology
R Joel Welch, Raksha Rao, Phillip S Gordon, Emil Anthony T Say, Carol L Shields
PURPOSE: To investigate hand-held optical coherence tomography (HH-OCT) characteristics of small (<1 mm thickness) retinoblastoma. DESIGN: Retrospective observational case series. METHODS: Patient and tumor data were extracted from the medical record and analyzed along with HH-OCT scans. Determination of tumor layer of origin was performed using a layer-by-layer analysis of HH-OCT data and specific HH-OCT-related features were described...
July 9, 2018: Asia-Pacific Journal of Ophthalmology
Sonali Raman, Sumeer Singh, V Jagdish
PURPOSE: The purpose of this study was to elucidate anesthesia-related challenges in 74 cases who underwent modified osteo-odonto-keratoprosthesis (MOOKP). DESIGN: Retrospective cohort study. METHODS: Medical records of 74 consecutive patients who underwent MOOKP surgery between January 2007 and January 2015 were studied. Data such as demographic details, systemic comorbidities, indications for MOOKP, anesthesia techniques, and postoperative events in various stages of MOOKP were collected and analyzed...
July 8, 2018: Asia-Pacific Journal of Ophthalmology
Mayinuer Yusufu, Ningli Wang
Much has been achieved in clinical and scientific research in the past 130 years by Beijing Tongren Hospital, which has evolved from an eye clinic to a comprehensive hospital with an ophthalmology department known as one of the best in China. This article presents the most historic moments and events in the development of a hospital with the largest eye care service volume. In addition, given the leading position of Tongren, the development of ophthalmology in Tongren is also the epitome of the development of modern ophthalmology in China...
June 28, 2018: Asia-Pacific Journal of Ophthalmology
Prem S Subramanian, Anthony C Arnold
No abstract text is available yet for this article.
July 2018: Asia-Pacific Journal of Ophthalmology
Leonard A Levin
Almost all optic neuropathies are untreatable, motivating the search for new therapies that address the final common pathway of optic nerve disease, retinal ganglion cell loss. These neuroprotective strategies have been primarily studied in glaucoma, the most common optic neuropathy, but increasing also tested at the laboratory and animal model level in nonglaucomatous optic neuropathies. More recently, several clinical trials, most of which are randomized, have begun to examine whether neuroprotection is efficacious in human optic nerve disease...
July 2018: Asia-Pacific Journal of Ophthalmology
Wayne T Cornblath
Myasthenia gravis is a relatively common neuromuscular disorder, with ocular myasthenia gravis being a subset defined as myasthenia gravis limited to the orbicularis, levator, and extraocular muscles. Patients with ocular myasthenia gravis can have disabling diplopia or functional blindness from ptosis and in most cases treatment is required. Like generalized myasthenia gravis, there are a variety of treatments available that include pyridostigmine, immunosuppression, intravenous immunoglobulin, plasmapheresis, thymectomy, lid crutches, ptosis surgery, and extraocular muscle surgery...
July 2018: Asia-Pacific Journal of Ophthalmology
Ungsoo Samuel Kim, Neringa Jurkute, Patrick Yu-Wai-Man
Leber hereditary optic neuropathy (LHON) is an important cause of mitochondrial blindness. The majority of patients harbor one of three mitochondrial DNA (mtDNA) point mutations, m.3460G>A, m.11778G>A, and m.14484T>C, which all affect complex I subunits of the mitochondrial respiratory chain. The loss of retinal ganglion cells in LHON is thought to arise from a combination of impaired mitochondrial oxidative phosphorylation resulting in decreased adenosine triphosphate (ATP) production and increased levels of reactive oxygen species...
July 2018: Asia-Pacific Journal of Ophthalmology
Caroline Halbach, Collin M McClelland, John Chen, Suellen Li, Michael S Lee
Giant cell arteritis (GCA) requires a prompt diagnosis to avoid significant morbidity among the elderly. An accurate diagnosis is also paramount given the side effect profile of long-term corticosteroid treatment. Temporal artery biopsy (TAB) has long remained the gold standard for the diagnosis of GCA but requires an invasive procedure that is not without risk. This article discusses the argument for and against the use of noninvasive imaging including ultrasound, magnetic resonance imaging, and positron emission tomography scanning for the diagnosis of GCA...
July 2018: Asia-Pacific Journal of Ophthalmology
Fiona Costello, Lasse Malmqvist, Steffen Hamann
An elevated optic nerve head can be an ominous sign, sometimes signifying an underlying basis for raised intracranial pressure. Alternatively, patients may harbor a different mechanism for this optic nerve head appearance, including optic disc drusen (ODD), which does not confer any life-threatening implications. It is important to refine the approach to distinguishing ODD from papilledema because this is a relatively common, and important, conundrum encountered in clinical practice. Optical coherence tomography (OCT) is a noninvasive, readily accessible, and cost-effective ocular imaging technique that can improve the diagnostic accuracy for detecting ODD; or, instead, increase the index of suspicion for papilledema, thus prompting additional investigations needed to identify (or exclude) potential causes of raised intracranial pressure...
July 2018: Asia-Pacific Journal of Ophthalmology
Leanne Stunkel, Gregory P Van Stavern
The etiologies of optic neuropathy include inflammation, ischemia, toxic and metabolic injury, genetic disease, and trauma. There is little controversy over the practice of using steroids in the treatment of optic neuritis--it is well established that intravenous steroid treatment can speed visual recovery but does not alter final visual function. However, there is controversy surrounding the acceptable routes of administration, dosage, and course of treatment. Additionally, the typical patient with optic neuritis is young and otherwise healthy, and thus is likely to tolerate steroids well...
July 2018: Asia-Pacific Journal of Ophthalmology
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