journal
MENU ▼
Read by QxMD icon Read
search

Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï

journal
https://www.readbyqxmd.com/read/26695931/research-of-dna-repair-genes-polymorphism-xrcc1-and-xpd-and-the-risks-of-thyroid-cancer-development-in-persons-exposed-to-ionizing-radiation-after-the-chornobyl-disaster
#1
V M Shkarupa, S O Henyk-Berezovska, V O Palamarchuk, V V Talko, S V Klymenko
OBJECTIVE: The objective of this work was to determine and compare the features of DNA repair gene XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms in patients with thyroid cancer (TC), who were exposed to ionizing radiation (IR) as a result of the Chornobyl disaster, and in patients without exposure to ionizing radiation in history. MATERIALS AND METHODS: Determination of gene XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms was performed by polymerase chain reaction (PCR) in 102 patients with thyroid cancer: 38 people, who were exposed to ionizing radiation due to Chornobyl disaster (members of the accident, and evacuees and residents from controlled areas contaminated with radionuclides), 64 individuals without exposure to ionizing radiation in history and 41 persons residents of Ukraine without cancer pathology in the control group...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695930/geno-and-cytotoxic-effects-in-bone-marrow-cells-and-peripheral-blood-induced-by-the-prolonged-administration-of-131i-to-the-laboratory-rats
#2
N M Ryabchenko, A I Lypska, O O Burdo, O A Sova, I P Drozd
OBJECTIVE: to evaluate the state of to assess the state of hematopoietic system of experimental rats according to the geno and cytotoxic effects in bone marrow and changes in morphology composition of peripheral blood caused by prolonged 131I intake. MATERIALS AND METHODS: Within 15 days sodium iodide with activity of 29,3 kBq/animal was daily orally administered to Wistar rats. At 1, 2, 3, 7 and 15 days specific radioisotope activity, level of micronuclei in bone marrow cells, cyto toxicity index, number of erythrocytes and leucocytes in peripheral blood were determined...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695929/pattern-changes-in-quantitative-and-qualitative-markers-of-hematopoietic-stem-cells-during-acute-and-chronic-exposure-to-90sr-isotope-in-cell-culture
#3
I Z Russu, N K Rodionova, D I Bilko, N M Bilko
OBJECTIVE: The objective of our research was investigation of the hematopoietic system of laboratory rats under the influence of acute and chronic internal exposure to 90Sr isotope. MATERIALS AND METHODS: To study the condition of stem cells and their immediate progenitors we implemented cell culture methodology in vivo in gel diffusion capsules with subsequent analysis of the colonies and clusters. RESULTS: On the basis of experiments it was established that long-term effects of incorporated 90Sr isotope leads to significant disturbances in the hematopoietic system and in particular, revealing changes in hematological parameters of irradiated animals such as the appearance of circulating progenitor cells in peripheral blood, reducing the colony-forming efficiency of the bone marrow derived progenitor cells, as well as quantitative and qualitative changes in the clones...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695928/effect-of-ultrasound-on-the-interleukin-content-in-blood-of-rats-with-experimental-inflammation
#4
N E Nurishchenko
UNLABELLED: The aim was to determine the effectiveness of anti-inflammatory action of ultrasound by the interleukin-6, interleukin-8 and tumor necrosis factor alpha content in the blood of rats with experimental inflammation. MATERIALS AND METHODS: the study was performed using conventional models of inflammation - carrageenan-induced edema of the limbs of rats. Content of interleukins IL-6 and IL-8 was determined by enzyme immunoassay (ELISA) according to a standard protocol Immunoassay kit IL-10, Biosourse (USA)...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695927/experimental-evaluation-of-2-merkaptobenztyazol-radioprotective-capacities-on-cell-cultures-test-system
#5
H M Litvinchuk, G Y Lavrenchuk, L M Litvinchuk, V S Asmolkova, O A Boyko
OBJECTIVE: To study the radioprotective properties of 2-merkaptobenztyazol on proliferating cell culture test system. MATERIALS AND METHODS: cytogenetic, cytological, statistics. RESULTS: Analysis of cytogenetic effects of 2-merkaptobenztiazol by frequency aberrations criteria and aberrant cells damage criteria showed that upon entire investigated range of reagent concentrations the frequency of aberrations was not significantly higher than the value of this indicator in control, but there was a tendency of reduction of mitotic activity of root meristem cells...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695926/impact-peculiarities-of-long-term-gamma-irradiation-with-low-dose-rate-on-the-development-of-laboratory-rats-and-their-sperm-production
#6
A V Klepko, O A Motrina, O S Vatlitsova, K S Andreichenko, S A Pchelovska, S V Andreychenko, L V Gorban
OBJECTIVE: To study the influence of long-term gamma-irradiation with low dose rate (13×10-6 cGy/s) on the body, testes and ventral prostate, development of laboratory rats, as well as quantitative parameters of sperm production along with kinetic characteristics of spermatozoa. MATERIALS AND METHODS: The experiments were performed on laboratory white rats of 2,5 months in age. Animals were irradiated in gamma-field of "Ethalon" device in a dose range 0.1-1.0 Gy...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695925/zeta-potential-response-of-human-erythrocyte-membranes-to-the-modulators-of-gardos-channel-activity-under-low-rate-%C3%AE-radiation
#7
V V Zhirnov, I N Iakovenko, V M Voitsitskiy, S V Khyzhnyak, O G Zubrikova-Chugainova, V A Gorobetz
OBJECTIVE: Study of human erythrocyte DP response under modification by activators and blockers of the functional state of Ca2+-dependent K+ channels under low rate β-radiation. MATERIALS AND METHODS: Erythrocytes were isolated from the donor blood. The zeta potential was computed from the value of the cell electrophoretic mobility. The investigated drugs preliminary introduced in cellular suspensions, and then aliquote of 90Sr(NO3)2 solution to get the final activity concentration of 44,4kBq⋅l-1...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695924/radiomodifying-and-antitoxic-effect-of-natural-polymineral-substances-on-the-viability-of-the-cell-line-l929-under-the-combined-exposure-to-ionizing-radiation-and-ions-of-heavy-metals
#8
D Hapieienko, H Lavrenchuk
OBJECTIVE: to study the radiomodifying and antitoxic effect of natural polymineral substances on cell viability in vitro under the combined exposure to ionizing radiation and ions of heavy metals. MATERIALS AND METHODS: Research was performed on an inoculated proliferating culture of the L929 cell line. Water soluble salts of lead acetate, copper, nickel and chromium oxide were added to the cell line culture at concentra tions of 0.01-10.00 μmol/L one hour before exposure to radiation at doses of 0...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695923/retinal-vascular-pathology-risk-development-in-the-irradiated-at-different-ages-as-a-result-of-chernobyl-npp-accident
#9
P A Fedirko, T F Babenko, R Yu Dorichevska, N A Garkava
OBJECTIVE: To assess the relationship between the age at which a person undergoes radiation exposure and risk of developing eye lesions (case study of the retinal angiopathy prevalence). MATERIALS AND METHODS: The object of the study was the state of the retinal vessels in 2,531 persons (1,948 evacuated from the city of Pripyat under the age of 20 and 583 exposed to radiation in utero as a result of the Chernobyl NPP disaster. The results of standardized ophthalmic examination conducted from 1993 to 2000 within the framework of Clinical and epidemiological registry are used for the analysis...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695922/optimization-of-chronic-obstructive-pulmonary-disease-treatment-in-clean-up-workers-of-the-chornobyl-npp-accident-in-the-remote-period-after-irradiation
#10
V O Sushko, L I Shvaiko, K D Bazyka, A S Riazhska
BACKGROUND: According to the results of the clinical and epidemiological studies in clean-up workers of Chernobyl NPP accident in the remote period were detected the growth of morbidity of chronic obstructive pulmonary disease with substantial features of pathomorphosis, that make difficulties for treatment. The aim of the study was to determine the effectiveness of long-term administration (6 months) combination Аmbroxol (30 mg x 3 times per day) and Essenciale (600 mg x 2 times per day) added to basic treatment in patients with moderate to severe COPD - clean-up workers of the Chornobyl NPP accident...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695921/the-morphological-changes-of-mucous-membrane-of-stomach-and-duodenum-of-contractor-organization-personnel-which-works-in-radiation-hazard-conditions-at-the-object-shelter-of-chornobyl-npp
#11
V O Sushko, G A Nezgovorova, L V Degtjarova, O O Kolosynska, V M Gromadska
UNLABELLED: Аim: The determination of morphological features of stomach and duodenum mucous of membrane (MM) damage at a personnel that works in radiation hazard conditions at the object of "Shelter" of Chornobyl NPP (OS) by the endoscopic monitoring with biopsy material inspection from a gastro-duodenal zone on the stages of check - in (InC) and the special medical control (SpC). MATERIALS AND METHODS: the complex clinical-endoscopic and morphological examination with the biopsy of MM of stomach and duodenum in 126 workers of OS (man in the age from 20 to 59) was carried out...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695920/influence-of-enos-gene-4a-b-vntr-polymorphism-on-development-of-endothelial-dysfunction-and-respiratory-system-disorders-in-children-residents-of-radioactively-contaminated-areas
#12
Ye I Stepanova, Ye Kolpakov, V M Zyhalo, O M Lytvynets, V H Kondrashova, V Yu Vdovenko, O O Skvarska, O S Leonovych
UNLABELLED: Objective is to study the role of еNOS gene polymorphism in the development of endothelial dysfunction and func tional disorders of the respiratory system in children - residents of radioactively contaminated areas. MATERIALS AND METHODS: Total of 184 children were examined to determine the possible associative links between еNOS gene intron 4m polymorphism and indices characterizing the functional state of the endothelium and the bronchopulmonary system...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695919/peculiarity-of-prooxidant-antioxidant-balance-indicators-in-patients-with-nonalcoholic-fatty-liver-disease-who-have-been-exposed-to-ionizing-radiation-due-to-the-chornobyl-npp-accident
#13
O V Nosach, L M Ovsyannikova, A A Chumak, S M Alekhina, E O Sarkisova, O V Hasanova, O Y Pleskach, G A Nezhovorova, A V Zelinska, O M Kadyuk
OBJECTIVE: To define the features of prooxidant antioxidant balance in patients with nonalcoholic fatty liver disease who have been exposed to radiation as a result of the Chornobyl accident. METHODS: using Indicators characterizing the processes of oxidative modification of macromolecules by blood lev els of compounds with isolated double bonds (CIDB), diene conjugates (DC) oxodiene conjugates (ODC), secondary products of lipid peroxiodation reacting with thiobarbituric acid, products of oxidative modification of proteins in blood serum by levels of neutral and basic 2,4 dynitrofenilhidrazones, superoxide dismutase and catalase content in erythrocytes and ceruloplasmin in plasma were determined for the diagnosis of oxidative stress...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695918/tp53-codon-72-polymorphic-variants-rs1042522-frequency-in-the-ukrainian-population
#14
Y M Mishchuk, S V Serga, O K Koliada, L I Ostapchenko, S V Demydov, I A Kozeretska
OBJECTIVE: To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population. MATERIALS AND METHODS: We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele specific polymerase chain reaction. RESULTS: We identified 31 individuals (20.9 %) with Arg/Arg genotype, Arg/Pro genotype was identified for 116 indi viduals (78.4 %), whereas genotype Pro/Pro was rare and was found in one person only (0...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695917/specifics-of-the-course-and-the-clinical-pictures-of-essential-thrombocythemia-depending-on-the-jak2v617f-status-of-the-patients
#15
O Y Mishcheniuk, O M Kostukevich, I V Dmytrenko, S V Klymenko
OBJECTIVE: The purpose of the study was to analyze the specific features of the relationship between the JAK2 V617Fmutation and clinical presentation, and risks of thrombosis in patients with spontaneous and radiation associated essential trombocitemia (ET). MATERIALS AND METHODS: Clinical, laboratory hematological, molecular genetic characteristics of ET patients were analyzed. The group of patients with radiation associated ET was represented by 10 individuals and the cohort of spontaneous ET represented by 111 persons...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695916/predictive-value-of-laboratory-hematological-parameters-for-thromboses-development-in-patients-with-spontaneous-and-radiation-associated-ph-negative-myeloproliferative-neoplasms
#16
O Yu Mishcheniuk, S V Klymenko
OBJECTIVE: To establish which of hematological parameters have discriminatory ability for forecast the development of thromboses in spontaneous and radiation associated Ph negative myeloproliferative neoplasms (MPN). MATERIALS AND METHODS: It was analyzed hematological parameters of 85 patients with polycythemia vera (PV), 43 - essential thrombocythemia (ET) and 40 - primary myelofibrosis (PMF). The main group consisted of patients (PV = 18, ET = 6, PMF = 18) which were exposed to ionizing radiation due to the Chornobyl accident, and control - patients (PV = 67, ET = 37, PMF = 22) without affecting emergency radiation in history...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695915/age-peculiarities-of-reproductive-morbidity-in-female-participants-of-the-chnpp-accident-consequences-clean-up-according-to-the-figures-from-sru-1988-2012-survey-period
#17
I O Mayevska, V O Buzunov
OBJECTIVE: to assess and estimate the peculiarities of genital system morbidity in female participants of the ChNPP accident clean up works in 1986-1987 depending on age at exposure to ionizing radiation and time since exposure. MATERIALS AND METHODS: Data on the Chernobyl disaster survivors received from the State Registry of Ukraine are out line in the paper. Review of the level and pattern of genital system morbidity was carried out for the 17,237 female participants of the ChNPP accident clean up works in 1986-1987 depending on time under risk upon radiation expo sure and reproductive age at exposure...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695914/state-of-oral-cavity-hygiene-siga-level-mineral-content-of-oral-fluid-and-optimization-of-preventive-intervention-in-children-with-enamel-hypoplasia-and-underlying-comorbidity
#18
S F Liubarets, O V Kopylova, T O Belingio, V M Kolbasynska, I M Sechina, T F Liubarets
OBJECTIVE: To advance the efficiency of tooth caries prevention in children with enamel hypoplasia through a com plex intervention focused at amelioration of oral hygiene, secretory immunoglobulin A (sIgA) level, and mineral con tent of oral fluid. MATERIALS AND METHODS: Hypoplasia of permanent teeth enamel was the target of research. State of oral cavity hygiene, sIgA, total calcium and orthophosphate content in oral fluid were the research subject. Enamel vital stain ing, transillumination, immunoenzymometric and photometric techniques were applied...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695913/non-cancer-thyroid-and-other-endocrine-disease-in-children-and-adults-exposed-to-ionizing-radiation-after-the-chnpp-accident
#19
O V Kaminskyi, O V Kopylova, D E Afanasyev, O V Pronin
STUDY OBJECTIVE: To summarize the verified clinical and epidemiological data on the natural history of non cancer endocrine disease in remote period after the ChNPP accident in survivors of adult and children age. MATERIALS AND METHODS: Retrospective estimation was carried out of data on 24,588 adult persons and 20,087 chil dren survived after the ChNNP accident and being healthy or having any diseases. Data were retrieved from database of the Clinical Epidemiological Registry (CER), NRCRM for the 23 years (1992-2014) of survey...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/26695912/assessment-of-response-to-imatinib-therapy-in-patients-with-chronic-myeloid-leukemia-with-e13a2-and-e14a2-transcripts-of-bcr-abl1-gene
#20
I V Dmytrenko, V G Fedorenko, T Y Shlyakhtychenko, V V Sholoyko, T F Lyubarets, T V Malinkina, O O Dmytrenko, V V Balan, S M Kravchenko, Z V Martina, A O Tovstogan, J M Minchenko, I S Dyagil
OBJECTIVE: Assess the influence of e13a2 and e14a2 transcripts of BCR/ABL1 gene on the efficiency of imatinib ther apy in patients with chronic myeloid leukemia. MATERIALS AND METHODS: We examined 508 patients with the chronic phase of chronic myeloid leukemia without radi ation in anamnesis as well as 13 patients with the similar diagnosis and with confirmed presence of radiation expo sure due to the Chornobyl Nuclear Power Plant accident. RESULTS: No significant differences in hematologic parameters, rate of additional chromosomal aberrations and f vari ant translocations were observed between patients with е13а2 and е14а2 transcript...
December 2015: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
journal
journal
48482
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"