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Annals of Neurosciences

Anu Raju, Parasuram Jaisankar, Anupom Borah, Kochupurackal Parameswarannayar Mohanakumar
Background/Aims: Hypercholesterolemia is recently considered a risk factor for Parkinson's disease (PD), the most consistent neurodegenerative movement disorder. The study aimed to investigate the effect of exogenous cholesterol on 1-methyl-4-phenylpyridinium (MPP+ ) parkinsonian neurotoxin-induced cell death, loss of mitochondrial membrane potential, and dopaminergic deficiency in a cellular model of PD. Methods: Cholesterol (50 μM) when added in the culture media alone or in combination with MPP+ was studied in SH-SY5Y neuroblastoma cells...
May 2018: Annals of Neurosciences
Siriluk Somredngan, Wachiryah Thong-Asa
Background: Chronic cerebral hypoperfusion (CCH) is associated with neurological changes and cognitive decline. It is a major cause of vascular dementia and a contributing factor in Alzheimer disease. Animal models are useful in helping to elucidate the mechanisms of these diseases while demonstrating differences in pathological onset and severity. Furthermore, different mouse strains show differences in their susceptibility to neurological damage resulting in different cognitive outcomes...
May 2018: Annals of Neurosciences
Pramod Kumar Singh, Manish Kumar Singh, Rajesh Singh Yadav, Rakesh Kumar Dixit, Anju Mehrotra, Rajendra Nath
Background: Lead is widely distributed in the environment and has been found to be associated with various health problems including neurodegenerative diseases. Purpose: In view of the increasing health risk caused by lead, this study has been carried out to investigate the neuroprotective effect of omega-3 fatty acid (omega-3FA) in lead-induced neurotoxicity in rats. Methods: Biochemical parameters including oxidative stress in brain regions, lead levels in blood and brain regions and histopathological examination of brain regions of rats were carried out in the present study...
May 2018: Annals of Neurosciences
Arun Parashar, Vineet Mehta, Udayabanu Malairaman
Objective: Diabetic neuropathy is a chronic and often disabling condition that affects a significant number of individuals with diabetes mellitus (DM). It is now established that DM causes various CNS complications like Alzheimer's, dementia, anxiety, depression, neurodegeneration, mood disorders, cognitive dysfunctioning, and so on. Since amygdala and dopaminergic circuitry are critical in controlling several aspects of social behavior, even social recognition memory (SRM), we aimed to study the expression analysis of dopaminergic circuitry in amygdala using real-time polymerase chain reaction...
May 2018: Annals of Neurosciences
Madhivanan Karthigeyan, Prankul Singhal, Pravin Salunke, Kirti Gupta
Extra-axial central nervous system lesions can occasionally involve the overlying calvarium. The involvement may be due to longstanding pressure effects or secondary to the aggressive behaviour of the lesion. The spectrum of such dural-based lesions varies from infectious/inflammatory to neoplastic etiology. We present a dural-based lesion with the erosion of the overlying calvarium in a young lady. In view of the short history with heterogenous enhancement on magnetic resonance imaging and bony erosion, hemangiopericytoma or malignant meningioma was suspected...
May 2018: Annals of Neurosciences
Anny Tzouma, Lazaros C Triarhou
This note is a tribute to Garth J. Thomas (1916-2008), late Professor of Brain Research at the University of Rochester, New York. Thomas was an influential psychologist, albeit for his research in learning and memory, as much as for his work as editor of the Journal of Comparative and Physiological Psychology . In his studies, he combined experimental lesions with behavioral analyses. He introduced the terms "dispositional" and "representational" to describe the 2 different types of memory function, and emphasized that memory must be studied not only through behavioristic psychology, but also in a molecular and physiological context...
May 2018: Annals of Neurosciences
Daisuke Tachiya, Tadasu Sato, Hiroyuki Ichikawa
By immunohistochemistry, an effect of nerve injury on distribution of alpha-2/delta-1 subunit of L-type calcium channel was investigated in rat's 4th and 5th lumbar dorsal root ganglia (DRGs), trigeminal ganglion (TG), and mesencephalic trigeminal nucleus (Mes5). The immunoreactivity was expressed by 52.2% of DRG neurons and 31.4% of TG neurons in intact animals. These neurons mostly had small-to-medium-sized cell bodies. In the DRG and TG, alpha-2/delta-1 subunit-positive neurons were lightly or moderately stained...
May 2018: Annals of Neurosciences
Afolabi Clement Akinmoladun, Ibrahim Olabayode Saliu, Boyede Dele Olowookere, Olubukola Benedicta Ojo, Mary Tolulope Olaleye, Ebenezer Olatunde Farombi, Afolabi Akintunde Akindahunsi
Background: Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury. Purpose: This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury...
April 2018: Annals of Neurosciences
Nidhi Prabhakar, Chirag K Ahuja, Niranjan Khandelwal
Bilateral basal ganglia lesions are a common non-specific finding seen in many diseases. One of the differential diagnoses for it, in a child, is kernicterus occurring due to hyperbilirubinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of severe hyperbilirubinemia. A 1-year old child presented to the hospital with history of generalized dystonia in the previous 3 days. MRI showed evidence of symmetrical lesions in bilateral globus pallidus, which were hyperintense on T2/FLAIR and isointense on T1...
April 2018: Annals of Neurosciences
Akshay Anand
No abstract text is available yet for this article.
April 2018: Annals of Neurosciences
Akshay Anand, Deepak P Pal
No abstract text is available yet for this article.
April 2018: Annals of Neurosciences
Ananda Gaihre, Sasidharan K Rajesh
Background: Chronic vulnerability characterizes substance abuse disorder with consequent relapse. The process of abstinence depends on cognitive recovery. Hence, behavioral intervention should account for cognitive dimension of substance abusers. Recent studies highlight yoga-based intervention as a promising add-on therapy for treating and preventing addictive behaviors. Purpose: The study aimed to evaluate the efficacy of a yoga-based intervention as an add-on in enhancing cognitive functions, compared with physical exercise to newly admitted substance abusers seeking an inpatient treatment program...
April 2018: Annals of Neurosciences
Md Sahab Uddin, Abdullah Al Mamun, Md Asaduzzaman, Fakhrul Hosn, Mohammad Abu Sufian, Shinya Takeda, Oscar Herrera-Calderon, Mohamed M Abdel-Daim, G M Sala Uddin, Md Ali Asif Noor, Mst Marium Begum, Md Tanvir Kabir, Sonia Zaman, Md Shahid Sarwar, Md Mosiqur Rahman, Md Rajdoula Rafe, Md Farhad Hossain, Md Sarwar Hossain, Mohammed Ashraful Iqbal, Md Ataur Rahman Sujan
Background: Neurological disorders represent one of the most prominent causes of morbidity and mortality that adversely affect the lifestyle of patients and a major percentage of these diseases exists in developing countries. Purpose: The objective of this study was to examine the prevalence and prescription pattern for outpatients with neurological disorders in Bangladesh. Methods: The study was conducted on 1,684 patients in 6 hospitals (National Institute of Neurosciences and Hospital, Dhaka Medical College and Hospital, Bangabandhu Sheikh Mujib Medical University, Shaheed Suhrawardy Medical College, Sir Salimullah Medical College, and Apollo Hospitals Dhaka) of the Dhaka City from March 2014 to June 2015...
April 2018: Annals of Neurosciences
Harilal Parasuram, Bipin Nair, Giovanni Naldi, Egidio D'Angelo, Shyam Diwakar
Background: The cerebellar granular layer input stage of cerebellum receives information from tactile and sensory regions of the body. The somatosensory activity in the cerebellar granular layer corresponds to sensory and tactile input has been observed by recording Local Field Potential (LFP) from the Crus-IIa regions of cerebellum in brain slices and in anesthetized animals. Purpose: In this paper, a detailed biophysical model of Wistar rat cerebellum granular layer network model and LFP modelling schemas were used to simulate circuit's evoked response...
April 2018: Annals of Neurosciences
Vijay Paramanik, Harini Krishnan, Mahendra Kumar Thakur
Background: Estrogen receptor (ER)α and ERβ are ligand-activated transcription factors that regulate gene expression by binding to estrogen-responsive elements and interacting with several coregulators through protein-protein interactions. Usually, these coregulators bind to the various conserved and functional domains of the receptor through a consensus LXXLL sequence, although variations can be found. The interaction of receptor domains and the consensus motif can be a possible target for nuclear receptor (NR) pharmacology, since modifications in these are responsible for possible pathogenesis of various diseases...
April 2018: Annals of Neurosciences
Christopher Donaldson, Bryden Dawes, Vivek Rathi, Kristian Bulluss
BACKGROUND: We report a 61-year-old who presented with a right-sided abducens nerve palsy secondary to a middle cranial fossa adenoid cystic carcinoma (ACC) extending into the cavernous sinus. PURPOSE: This case represents a unique presentation of intracranial ACC with a large middle cranial fossa mass and only a small extracranial component. METHODS: Review of the literature was undertaken to identify cases of intracranial ACC and their range of presentations...
July 2017: Annals of Neurosciences
Rajesh Chhabra, Manjul Tripathi, Devi Prasad Patra, Narendra Kumar, Bishan Radotra, Kanchan Kumar Mukherjee
BACKGROUND: Extraskeletal mesenchymal chondrosarcoma (ESMCS) is an unusual pathologic variant of chondrosarcoma. There are no specific clinicoradiographic parameters to distinguish it from other intracranial pathologies. The diagnosis can be established only on the basis of histopathology, which may pose significant challenges in certain unusual locations. PURPOSE: In this case, we discuss the pitfalls in diagnosis, management, and major characteristics of ESMCS with a review of current literature...
July 2017: Annals of Neurosciences
Rahul Tyagi
No abstract text is available yet for this article.
July 2017: Annals of Neurosciences
Ruchi Yadav, Deepshikha Deepshikha, Prachi Srivastava
CHRNA7 is a neurodevelopmental protein involved in differentiation and neurogenesis, which is also named as nicotinic acetylcholine receptors, cholinergic receptor, nicotinic, alpha 7 (neuronal). The protein encoded by this gene forms a homo-oligomeric channel. It is a major component of brain nicotinic receptors displays that are blocked by and sensitive to alpha-bungarotoxin. Studies reports involvement of CHRNA7 protein in different neurological diseases. Non-availability of 3-dimensional (3D) structure leads the study toward structure 3D prediction along with its interaction analysis...
July 2017: Annals of Neurosciences
Olugbenga Ayodeji Ayannuga, Thajasvarie Naicker
BACKGROUND: Oligodendrocytes are critical to the function of the brain. They generate the myelin sheath which ensures saltatory conduction, which is a more energy saving and efficient means of axonal impulse transmission. Ventriculomegaly results in neuronal degeneration and astrogliosis. PURPOSE: The effect of the degree of ventriculomegaly on oligodendrocyte in kaolin-induced hydrocephalus and the timeline have not been extensively documented, hence this study...
July 2017: Annals of Neurosciences
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