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Annals of Neurosciences

Vivek Podder, Amy Price, Madhava Sai Sivapuram, Ashwini Ronghe, Srija Katta, Avinash Kumar Gupta, Rakesh Biswas
Background: In this study, we demonstrate a collective collaborative, conversational, pre-publication peer review of a randomized controlled trial. Methods: Using Critical Appraisal Skills Programme checklist, a group of research-oriented undergraduate medical and pharmacy students and their teacher collectively on an online forum, discuss and review a randomized controlled trial submitted to the Annals of Neurosciences and the explanatory commentary from each reviewer makes a basic scaffold for critical appraisal of the manuscript...
July 2018: Annals of Neurosciences
Doniparthi Venkata Seshagiri, Ragasudha Botta, Arun Sasidharan, Pramod Kumar Pal, Sanjeev Jain, Ravi Yadav, Bindu M Kutty
Objective: The effect of thalamic degeneration in patients with spinocerebellar ataxias (SCA) and sleep spindle (SS) abnormalities has not been studied so far, although there is a strong association between these disorders. This study was done to evaluate and compare the SS densities (SSDs) of genetically proven autosomal dominant SCA1, SCA2 and SCA3 patients with controls. Methods: Prospectively and genetically confirmed cases of SCA and controls were recruited...
July 2018: Annals of Neurosciences
Olga Korzhyk, Olena Morenko, Alevtyna Morenko, Ihor Kotsan
Background: The ability to control motor actions and flexibly interact with the environment is considered one of the main components of the human brain executive functions. The spontaneous electroencephalogram (EEG) is among the physiological techniques making it possible to formulate a direct estimation of specific features of the activity of the human brain during manual movements. Purpose: This study is devoted to an investigation of brain processes in men with a high or a low individual α-frequency determined during manual movements executed by the subdominant hand...
July 2018: Annals of Neurosciences
Subramanian Thangaleela, Vasudevan Shanmugapriya, Murugan Mukilan, Karuppasamy Radhakrishnan, Koilmani Emmanuvel Rajan
Background: Earlier, we showed that nicotinamide (NAM) treatment impairs spatial memory through the downregulation of CREB-Sirt 1-brain-derived neurotrophic factor ( Bdnf ) signaling cascade. Purpose: In this study, we examine whether NAM treatment alters CREB-regulated genes through -microRNAs. Method: To test this hypothesis, goldfish ( Carassius auratus ) were divided into 2 groups: (i) vehicle group (VEH; double distilled water intra-peritoneally [i...
July 2018: Annals of Neurosciences
Lavnika Dubey, Suruliraj Karthikbabu, Divya Mohan
Background: Pelvic instability is a common occurrence during standing and walking post stroke. Inappropriate muscle activation and poor movement control around the pelvis lead to difficulty in mobility and daily functioning. Purpose: The purpose of the study was to examine the effects of pelvic stability training on the movement performance of trunk and lower limb, hip muscles strength, walking speed and daily activities after stroke. Methods: This randomized controlled trial involved 34 patients aged 56 (11) years with the post stroke duration being 31 (22) weeks...
July 2018: Annals of Neurosciences
Shweta Modgil, Rajesh Gill, Vijay Lakshmi Sharma, Sebastian Velassery, Akshay Anand
Nobel Prize is the highest honor in the scientific community that is bestowed for the contribution of eminent scientists in various spheres of science. Since its inception in 1901, many renowned scientists have received this award. However, when compared to men, women's share as recipients is abysmally low. Although the contribution of female scientists has tremendously increased in the last few decades, yet the lack of proportionate increase in recognition is conspicuous by its disproportionate number of women recipients...
July 2018: Annals of Neurosciences
Anu Raju, Parasuram Jaisankar, Anupom Borah, Kochupurackal Parameswarannayar Mohanakumar
Background/Aims: Hypercholesterolemia is recently considered a risk factor for Parkinson's disease (PD), the most consistent neurodegenerative movement disorder. The study aimed to investigate the effect of exogenous cholesterol on 1-methyl-4-phenylpyridinium (MPP+ ) parkinsonian neurotoxin-induced cell death, loss of mitochondrial membrane potential, and dopaminergic deficiency in a cellular model of PD. Methods: Cholesterol (50 μM) when added in the culture media alone or in combination with MPP+ was studied in SH-SY5Y neuroblastoma cells...
May 2018: Annals of Neurosciences
Siriluk Somredngan, Wachiryah Thong-Asa
Background: Chronic cerebral hypoperfusion (CCH) is associated with neurological changes and cognitive decline. It is a major cause of vascular dementia and a contributing factor in Alzheimer disease. Animal models are useful in helping to elucidate the mechanisms of these diseases while demonstrating differences in pathological onset and severity. Furthermore, different mouse strains show differences in their susceptibility to neurological damage resulting in different cognitive outcomes...
May 2018: Annals of Neurosciences
Pramod Kumar Singh, Manish Kumar Singh, Rajesh Singh Yadav, Rakesh Kumar Dixit, Anju Mehrotra, Rajendra Nath
Background: Lead is widely distributed in the environment and has been found to be associated with various health problems including neurodegenerative diseases. Purpose: In view of the increasing health risk caused by lead, this study has been carried out to investigate the neuroprotective effect of omega-3 fatty acid (omega-3FA) in lead-induced neurotoxicity in rats. Methods: Biochemical parameters including oxidative stress in brain regions, lead levels in blood and brain regions and histopathological examination of brain regions of rats were carried out in the present study...
May 2018: Annals of Neurosciences
Arun Parashar, Vineet Mehta, Udayabanu Malairaman
Objective: Diabetic neuropathy is a chronic and often disabling condition that affects a significant number of individuals with diabetes mellitus (DM). It is now established that DM causes various CNS complications like Alzheimer's, dementia, anxiety, depression, neurodegeneration, mood disorders, cognitive dysfunctioning, and so on. Since amygdala and dopaminergic circuitry are critical in controlling several aspects of social behavior, even social recognition memory (SRM), we aimed to study the expression analysis of dopaminergic circuitry in amygdala using real-time polymerase chain reaction...
May 2018: Annals of Neurosciences
Madhivanan Karthigeyan, Prankul Singhal, Pravin Salunke, Kirti Gupta
Extra-axial central nervous system lesions can occasionally involve the overlying calvarium. The involvement may be due to longstanding pressure effects or secondary to the aggressive behaviour of the lesion. The spectrum of such dural-based lesions varies from infectious/inflammatory to neoplastic etiology. We present a dural-based lesion with the erosion of the overlying calvarium in a young lady. In view of the short history with heterogenous enhancement on magnetic resonance imaging and bony erosion, hemangiopericytoma or malignant meningioma was suspected...
May 2018: Annals of Neurosciences
Anny Tzouma, Lazaros C Triarhou
This note is a tribute to Garth J. Thomas (1916-2008), late Professor of Brain Research at the University of Rochester, New York. Thomas was an influential psychologist, albeit for his research in learning and memory, as much as for his work as editor of the Journal of Comparative and Physiological Psychology . In his studies, he combined experimental lesions with behavioral analyses. He introduced the terms "dispositional" and "representational" to describe the 2 different types of memory function, and emphasized that memory must be studied not only through behavioristic psychology, but also in a molecular and physiological context...
May 2018: Annals of Neurosciences
Daisuke Tachiya, Tadasu Sato, Hiroyuki Ichikawa
By immunohistochemistry, an effect of nerve injury on distribution of alpha-2/delta-1 subunit of L-type calcium channel was investigated in rat's 4th and 5th lumbar dorsal root ganglia (DRGs), trigeminal ganglion (TG), and mesencephalic trigeminal nucleus (Mes5). The immunoreactivity was expressed by 52.2% of DRG neurons and 31.4% of TG neurons in intact animals. These neurons mostly had small-to-medium-sized cell bodies. In the DRG and TG, alpha-2/delta-1 subunit-positive neurons were lightly or moderately stained...
May 2018: Annals of Neurosciences
Afolabi Clement Akinmoladun, Ibrahim Olabayode Saliu, Boyede Dele Olowookere, Olubukola Benedicta Ojo, Mary Tolulope Olaleye, Ebenezer Olatunde Farombi, Afolabi Akintunde Akindahunsi
Background: Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury. Purpose: This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury...
April 2018: Annals of Neurosciences
Nidhi Prabhakar, Chirag K Ahuja, Niranjan Khandelwal
Bilateral basal ganglia lesions are a common non-specific finding seen in many diseases. One of the differential diagnoses for it, in a child, is kernicterus occurring due to hyperbilirubinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of severe hyperbilirubinemia. A 1-year old child presented to the hospital with history of generalized dystonia in the previous 3 days. MRI showed evidence of symmetrical lesions in bilateral globus pallidus, which were hyperintense on T2/FLAIR and isointense on T1...
April 2018: Annals of Neurosciences
Akshay Anand
No abstract text is available yet for this article.
April 2018: Annals of Neurosciences
Akshay Anand, Deepak P Pal
No abstract text is available yet for this article.
April 2018: Annals of Neurosciences
Ananda Gaihre, Sasidharan K Rajesh
Background: Chronic vulnerability characterizes substance abuse disorder with consequent relapse. The process of abstinence depends on cognitive recovery. Hence, behavioral intervention should account for cognitive dimension of substance abusers. Recent studies highlight yoga-based intervention as a promising add-on therapy for treating and preventing addictive behaviors. Purpose: The study aimed to evaluate the efficacy of a yoga-based intervention as an add-on in enhancing cognitive functions, compared with physical exercise to newly admitted substance abusers seeking an inpatient treatment program...
April 2018: Annals of Neurosciences
Md Sahab Uddin, Abdullah Al Mamun, Md Asaduzzaman, Fakhrul Hosn, Mohammad Abu Sufian, Shinya Takeda, Oscar Herrera-Calderon, Mohamed M Abdel-Daim, G M Sala Uddin, Md Ali Asif Noor, Mst Marium Begum, Md Tanvir Kabir, Sonia Zaman, Md Shahid Sarwar, Md Mosiqur Rahman, Md Rajdoula Rafe, Md Farhad Hossain, Md Sarwar Hossain, Mohammed Ashraful Iqbal, Md Ataur Rahman Sujan
Background: Neurological disorders represent one of the most prominent causes of morbidity and mortality that adversely affect the lifestyle of patients and a major percentage of these diseases exists in developing countries. Purpose: The objective of this study was to examine the prevalence and prescription pattern for outpatients with neurological disorders in Bangladesh. Methods: The study was conducted on 1,684 patients in 6 hospitals (National Institute of Neurosciences and Hospital, Dhaka Medical College and Hospital, Bangabandhu Sheikh Mujib Medical University, Shaheed Suhrawardy Medical College, Sir Salimullah Medical College, and Apollo Hospitals Dhaka) of the Dhaka City from March 2014 to June 2015...
April 2018: Annals of Neurosciences
Harilal Parasuram, Bipin Nair, Giovanni Naldi, Egidio D'Angelo, Shyam Diwakar
Background: The cerebellar granular layer input stage of cerebellum receives information from tactile and sensory regions of the body. The somatosensory activity in the cerebellar granular layer corresponds to sensory and tactile input has been observed by recording Local Field Potential (LFP) from the Crus-IIa regions of cerebellum in brain slices and in anesthetized animals. Purpose: In this paper, a detailed biophysical model of Wistar rat cerebellum granular layer network model and LFP modelling schemas were used to simulate circuit's evoked response...
April 2018: Annals of Neurosciences
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