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Wounds: a Compendium of Clinical Research and Practice

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https://www.readbyqxmd.com/read/28355144/the-effect-of-negative-pressure-wound-therapy-with-antiseptic-instillation-on-biofilm-formation-in-a-porcine-model-of-infected-spinal-instrumentation
#1
Devinder P Singh, Arvind U Gowda, Karan Chopra, Michael Tholen, Sarah Chang, Vasilios Mavrophilipos, Nina Semsarzadeh, Yvonne Rasko, Luther Holton Iii
OBJECTIVE: This study evaluates the effect of negative pressure wound therapy with antiseptic instillation (NPWTi) in the clearance of infection and biofilm formation in an in vivo model of infected spinal implants compared to traditional treatment modalities. MATERIALS AND METHODS: Five pigs underwent titanium rod implantation of their spinous processes followed by injection of 1 x 106 CFUs/100μL of methicillin-resistant Staphylococcus aureus through the fascia at each site...
March 24, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28355143/an-experience-of-an-individual-with-a-chronic-wound-in-an-open-abdomen-a-grounded-theory
#2
Alejandra Fuentes-Rami Rez
The open abdomen (OA) surgical technique has become an option for treating complex abdominal injuries; however, complications leading to late closure conditions might arise. In these cases the wound must be left open, which greatly impacts the patient's life. OBJECTIVE: The author aims to describe the experiences of individuals with a chronic OA wound. METHODS: Qualitative design using grounded theory was utilized. This study was carried out with a group of 28 adults who were treated with OA technique and whose wound had remained open for more than a month in duration and only received outpatient wound care...
March 24, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28355142/effects-of-adrenomedullin-and-glucagon-like-peptide-on-distal-flap-necrosis-and-vascularity-the-role-of-receptor-systems-and-nitric-oxide
#3
Betul Cam, Deniz Bagdas, M Ozgur Ozyigit, Engin Sagdilek, Naciye Isbil Buyukcoskun, Kasım Ozluk
OBJECTIVE: Flap necrosis in the distal area due to the deficiency of blood circulation is a major complication in flap treatment. In many previous studies, some natural substances such as chlorogenic acid, adrenomedullin (ADM), and glucagon-like peptide-1 (GLP-1) have been used to improve flap viability via their vasodilator, angiogenic, and antioxidant effects. The aim of this study is to clarify the mechanism through the use of selective antagonists for calcitonin gene-related peptide (CGRP) receptors and GLP-1 receptors such as CGRP-(8-37), exendin-(9-39), respectively, in the flap healing effects of ADM and GLP-1...
March 24, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28267679/the-effect-of-silver-coated-dressing-on-pain-management-and-hospitalization-duration-in-pediatric-partial-thickness-burns-a-retrospective-matched-cohort-study
#4
Itay Wiser, Ophir Schein, Julietta D Rubin, Roni Averbuch Sagie, Iris Reshef, Adi Lotan, Avshalom Shalom
OBJECTIVE: Daily burn wound dressing protocols elicit pain and anxiety, especially in pediatric burn patients. Novel dressing technologies reduce pain by obviating the need for frequent dressing changes. The objective of this study was to assess the effect of silver-coated dressings (SCDs) on pain management and outcomes in pediatric burn patients. MATERIALS AND METHODS: A retrospective, matched cohort study compared a SCD to standard dressing protocols in admitted pediatric burn patients...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28267678/enzymatic-debridement-of-chronic-nonischemic-diabetic-foot-ulcers-results-of-a-randomized-controlled-trial
#5
Juan Carlos Jimenez, Patrick S Agnew, Perry Mayer, John R Clements, Joseph M Caporusso, Darrell L Lange, Jaime E Dickerson, Herbert B Slade
OBJECTIVE: The aim of this randomized, controlled multicenter trial was to evaluate the clinical outcomes associated with the use of clostridial collagenase ointment (CCO) for up to 12 weeks in 215 patients with type 1 or type 2 diabetes mellitus and a neuropathic, nonischemic diabetic foot ulcer (DFU). MATERIALS AND METHODS: Patients were randomized into either a group receiving CCO applied once daily at a thickness of ~2 mm or a group receiving standard care (SC) consisting of a daily application of a hydrogel as needed to maintain a moist ulcer environment...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28267677/diabetic-foot-ulcers-treated-with-porcine-urinary-bladder-extracellular-matrix-and-total-contact-cast-interim-analysis-of-a-randomized-controlled-trial
#6
Oscar M Alvarez, Tashara Smith, Thomas W Gilbert, Neh J Onumah, Martin E Wendelken, Rachelle Parker, Lee Markowitz
OBJECTIVE: To evaluate the effectiveness of a porcine urinary bladder-derived extracellular matrix (UBM) for the treatment of recalcitrant, neuropathic diabetic foot ulcers (DFUs). MATERIALS AND METHODS: This prospective, parallel, randomized, single-center study involving 17 subjects was performed in an outpatient wound care center setting. Each subject with a DFU was randomized (2:1) to receive the urinary bladder matrix (UBM) plus offloading with a total contact cast (TCC) or standard care (nonadherent dressing plus TCC)...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28448265/evidence-corner-exploring-social-isolation-of-leg-ulcer-patients
#7
Laura Bolton
No abstract text is available yet for this article.
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28448264/use-of-ovine-based-collagen-extracellular-matrix-and-gentian-violet-methylene-blue-antibacterial-foam-dressings-to-help-improve-clinical-outcomes-in-lower-extremity-wounds-a-retrospective-cohort-study
#8
Eric L Lullove
Dressings that provide broad spectrum metalloprotease reduction along with inherent aspects of an extracellular matrix may contribute to improved wound healing outcomes and shorter treatment times. OBJECTIVE: The author performed a retrospective case series analysis to determine the clinical outcomes of regular debridement with the use of ovine-based collagen extracellular matrix dressings and gentian violet/methylene blue polyurethane antibacterial foam dressings in treating 53 patients with 53 chronic lower extremity wounds (diabetic foot ulcers [DFUs], venous leg ulcers, and heel pressure ulcers)...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28448263/zinc-and-wound-healing-a-review-of-zinc-physiology-and-clinical-applications
#9
Samuel Kogan, Aditya Sood, Mark S Garnick
Our understanding of the role of zinc in normal human physiology is constantly expanding, yet there are major gaps in our knowledge with regard to the function of zinc in wound healing. This review aims to provide the clinician with sufficient understanding of zinc biology and an up-to-date perspective on the role of zinc in wound healing. Zinc is an essential ion that is crucial for maintenance of normal physiology, and zinc deficiency has many manifestations ranging from delayed wound healing to immune dysfunction and impairment of multiple sensory systems...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28448262/an-unusually-large-carbuncle-of-the-temporofacial-region-demonstrating-remarkable-post-debridement-wound-healing-process-a-case-report
#10
Humaid Ahmad, Sheeraz Shakoor Siddiqui
Skin carbuncles are debilitating skin infections commonly seen in elderly patients with diabetes. These infections develop when a cluster of adjacent furuncles coalesce to form one inflammatory mass. While they commonly occur on the nape of the neck and back, rarer sites involving the face and head have been noted. Management of these rare sites is urgent because of the potential intracranial complications and the surgical outcome is often unsatisfactory due to associated facial scarring. Intraoral drainage is advocated to avoid this; however, when the carbuncle involves a larger area, debridement from the exterior is necessary...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28135202/using-a-radial-diffusion-method-to-investigate-the-role-of-plasmin-degradation-of-fibrin-in-a-physical-model-of-an-early-phase-wound
#11
Chima P Chukwuemeka, Jann Cupp, Jonathan R Sanders
BACKGROUND: Fibrin clot formation, which acts to stabilize a wound following injury, is among the key early aspects of dermal wound healing. This preliminary matrix is eventually degraded via a process known as fibrinolysis and replaced with a collagen-rich matrix that continues to be remodeled to minimize scarring. Disruptions in these carefully coordinated events lead to certain undesirable conditions such as fibrosis and the formation of abnormal scars that are associated with excess amounts of collagen...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28135200/evaluating-the-effect-of-3-papain-gel-application-in-cutaneous-wound-healing-in-mice
#12
Flávia Figueiredo Azevedo, Letícia P Santanna, Vanessa C Bóbbo, Edson A Libert, Eliana P Araújo, Mário Abdalla Saad, Maria Helena M Lima
While the US Food and Drug Administration has not approved the use of 3% papain gel in the United States, the authors feel this study adds to the literature regarding its use. INTRODUCTION: The aim of this study was to evaluate the effect of 3% papain gel on wounds in mice. MATERIALS AND METHODS: Thirty healthy C57BL mice (25-30 g) aged 10 weeks were randomly divided into 2 groups: mice treated with 3% papain gel and mice treated with placebo gel. Skin incisions were performed with a 6-mm metallic punch with a cutting blade edge...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28355141/editorial-message-compliance-revisited
#13
Terry Treadwell
No abstract text is available yet for this article.
March 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28355140/pretibial-myxedema-masquerading-as-a-venous-leg-ulcer
#14
Ingrid Herskovitz, Olivia Hughes, Flor MacQuhae, Robert S Kirsner
The authors report a case of pretibial myxedema (PTM) masquerading as a venous leg ulcer to alert wound care clinicians to this diagnostic possibility. Pretibial myxedema is a localized form of mucin cutaneous deposition characterized by indurated plaques most commonly on anterior legs. It is more likely to present in patients with Graves' disease, but it can be found in euthyroid patients as well. The physiopathology of PTM is complex, and there is an accumulation of highly hydrophilic glycosaminoglycans in the dermis...
March 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28355139/levamisole-induced-necrosis-syndrome-presentation-and-management
#15
Charles Fredericks, James R Yon, Gillian Alex, Molly Morton, Thomas Messer, Faran Bokhari, Stathis Poulakidas
Levamisole is an antihelminthic drug with immunomod- ulatory properties. Recent estimates suggest the majority of the cocaine in the United States is adulterated with levamisole. Le- vamisole-induced necrosis syndrome (LINES) is characterized by vasculitis, neutropenia, and purpura that progresses to skin necro- sis. Diagnosis relies on physical examination ndings and history of previous cocaine use. The purpose of this case series is to describe the pathophysiology, diagnosis, and management of LINES. The au- thors' institutional database was reviewed from 2008 to 2015, and they found 3 patients with LINES...
March 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054921/evaluation-of-the-effects-of-air-pollutants-on-diabetic-wounds
#16
Young Suk Choi, Il-Hoon Sung, Ji Yun Lim, A Hyun Kyun, Eui Dong Yeo, Sun Geun Lee, Young Koo Lee
BACKGROUND: Although air pollution containing fine dust particles is gaining attention worldwide, little is known about the effects of such pollutants on diabetic wounds. Air pollutants from diesel exhaust particles (DEPs) cause inflammation, resulting in an increased expression of pro-inflammatory cytokines and chemo- kines, which attract monocytes and T cells to the sites of inflamma- tion. The authors evaluated the effects of air pollutants on diabetic wounds. MATERIALS AND METHODS: Fibroblast cells were derived from streptozotocin-induced diabetic rats...
March 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054920/evaluation-of-honey-as-a-topical-therapy-for-intraoral-wound-healing-in-rats
#17
Goli Chamani, Mohammad Reza Zarei, Mitra Mehrabani, Ali Mehdavinezhad, Mehrangiz Vahabian, Fatemah Ahmadi-Motamayel
OBJECTIVE: Honey is one of the oldest known medicines. Its medical and therapeutic importance has been recently rediscovered. Honey is an effective treatment for infected wounds and ulcers. The aim of this study was to determine the effect of honey as a topical therapy for intraoral wound healing in rats. MATERIALS AND METHODS: Thirty-two male rats were divided into experimental and control groups (consisting of 16 rats, 4 animals in each group). A 2-mm mucosal defect was made to the depth of the periosteum using punch biopsy...
March 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272017/effects-of-hypericum-perforatum-on-an-experimentally-induced-diabetic-wound-in-a-rat-model
#18
Mehmet Farsak, Görkemo Özdağli, Doğay Özmüş, Ülkü Çömelekoğlu, Serap Yalın, Rabia Bozdoğan Arpacı, Ramazan Gen, Arzu Kanık, Derya Ümit Talas
OBJECTIVE: The aim of this study was to investigate the probable effects of Hypericum perforatum (HP) on wound healing in diabetic rats. MATERIALS AND METHODS: Thirty-five male Wistar rats were divided evenly into 5 groups. Diabetes formation was induced by intraperitoneal streptozotocin (60 mg/kg) administration for groups 1 (HP extract in olive oil), 2 (HP extract in ethanol), 3 (povidone-iodine application), and 4 (diabetic rats without any applied medication); group 5 was the control...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272016/cactus-spine-wounds-a-case-report-and-short-review-of-the-literature
#19
Raymond A Dieter, Lisa R Whitehouse, Rebecca Gulliver
INTRODUCTION: Cactus plants are commonly seen in arid southwestern regions of the United States. Due to their ready availability, they have become a popular houseplant. The spines or glochidia can easily puncture the skin with only minor pressure (ie, bumping or touching the cactus). Removal of the offending spine is difficult, even with tweezers. CASE: An 18-year-old woman initially self-removed the spines, and marked discomfort and intense erythematous reaction developed within 8 to 10 hours...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272015/evidence-corner-diagnosing-diabetic-foot-osteomyelitis
#20
Laura Bolton
No abstract text is available yet for this article.
February 2017: Wounds: a Compendium of Clinical Research and Practice
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