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Wounds: a Compendium of Clinical Research and Practice

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https://www.readbyqxmd.com/read/29718813/efficacy-of-honeydew-honey-and-blossom-honey-on-full-thickness-wound-healing-in-mice
#1
Takuto Sawazaki, Yukari Nakajima, Tamae Urai, Kanae Mukai, Megumi Ohta, Ikuko Kato, Azusa Kawaguchi, Yui Kinoshita, Yuri Kumagai, Ayaka Sakashita, Asuka Yamazaki, Toshio Nakatani
INTRODUCTION: The wound healing properties of honey, including blossom honey, are well known; however, the effects of honeydew honey during the wound healing process have not yet been investigated and thus remain unclear. OBJECTIVE: This study compares the effects of honeydew honey with those of blossom honey. MATERIALS AND METHODS: A total of 140 mice were divided into 2 control groups, which received either a hydrocolloid dressing (HCD; n = 22) or gauze (n = 22), and 4 experimental groups: honeydew honey (n = 23), Acacia honey (n = 23), Manuka honey (n = 22), and Japanese Pharmacopoeia honey (n = 28)...
April 20, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718812/safety-and-efficacy-of-an-autologous-blood-clot-product-in-the-management-of-texas-1a-or-2a-neuropathic-diabetic-foot-ulcers-a-prospective-multicenter-open-label-pilot-study
#2
Robert J Snyder, Maria A Kasper, Keyur Patel, Marissa J Carter, Igal Kushnir, Alon Kushnir, Thomas E Serena
OBJECTIVE: This pilot study evaluates safety in terms of the occurrence of adverse events (AEs) as well as the efficacy in terms of complete wound healing rates of a blood clot product when applied to chronic neuropathic diabetic foot ulcers (DFUs). MATERIALS AND METHODS: Participants were chosen from patients with DFUs visiting the wound care clinic. Up to 10 mL of blood drawn from each participant was injected into the product's clotting tray. Within 12 minutes, the blood clot product was formed, applied to the single DFU of each participant, and covered with primary and secondary dressings...
April 20, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718811/a-total-offloading-foot-brace-for-treatment-of-diabetic-foot-ulcers-results-from-a-halted-randomized-controlled-trial
#3
David J Johnson, Barbara J Saar, Andrew J Shevitz, Ann H Kim, Lori Hammer, Daniel E Kendrick, Pamela Moorehead, Vikram S Kashyap
INTRODUCTION: Foot offloading is the mainstay treatment for plantar diabetic foot ulcers (DFUs). OBJECTIVE: This multicenter, single-blinded, randomized controlled trial evaluates the efficacy of a total offloading foot brace for healing plantar DFUs. MATERIALS AND METHODS: Seventeen patients were randomized to standard therapy (ie, reducing stress and pressure via mechanical offloading) or offloading foot brace. Comparison of plantar pressures was performed using digital pressure sensing films...
April 18, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718810/comparison-of-dna-damage-and-apoptosis-induced-by-silver-nanoparticle-containing-dressing-materials-during-wound-healing
#4
Young Suk Choi, Heui-Chul Gwak, Jae Keun Park, Ji Yun Lim, Eui Dong Yeo, Eunseok Park, Junyong Kim, Young Koo Lee
INTRODUCTION: Silver nanoparticle (AgNP)-containing dressings are used worldwide for the treatment of wounds; however, many studies have indicated that AgNPs are toxic to humans and cause cell death, primarily via apoptosis. OBJECTIVE: In this study, the investigators compare the apoptotic effects of various AgNP dressing materials, with the hypothesis that nanosilver would be less toxic than ionic silver. MATERIALS AND METHODS: For the in vivo experiments, Sprague-Dawley (SD) and streptozotocin (STZ)-induced diabetic rats were treated with 5 dressing materials: Aquacel Ag (product A, silver ion; ConvaTec, Berkshire, UK), Acticoat (product B, AgNP; Smith & Nephew, Fort Worth, TX), Medifoam Silver (product C, silver ion; Genewel Science Co Ltd, Seongnam, South Korea), PolyMem Silver (product D, AgNP; Ferris Mfg Corp, Fort Worth, TX), and Vaseline-impregnated dressing gauze (control; Unilever, London, UK)...
April 13, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29521644/cost-effectiveness-analysis-of-silver-delivery-approaches-in-the-management-of-partial-thickness-burns
#5
Leo Nherera, Paul Trueman, Christopher Roberts, Leena Berg
INTRODUCTION: Burn injury is a common type of traumatic injury that causes considerable morbidity and mortality, resulting in about 30,000 admissions annually in specialist burn centers and costing around $1 billion per year in the United States. One percent silver sulfadiazine has been utilized widely in the management of burns and newer silver dressings are on the market, including nanocrystalline silver dressings, silver-impregnated hydrofiber dressings, and silver-impregnated foam dressings...
February 23, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29521643/clinic-based-debridement-of-chronic-ulcers-has-minimal-impact-on-bacteria
#6
Paul J Kim, Christopher E Attinger, Thomas Bigham, Robert Hagerty, Samantha Platt, Ersilia Anghel, John S Steinberg, Karen K Evans
Outpatient-based sharp debridement is considered an important element for the care of a chronic ulcer. OBJECTIVE: The aim of this study is to evaluate the change in bacterial amounts with sharp debridement in a clinical setting. MATERIALS AND METHODS: Bacterial autofluorescence, quantitative cultures, semiquantitative cultures, and qualitative speciation were performed predebridement and postdebridement during a single clinic visit. RESULTS: Thirty-six wounds were included in the analysis...
February 23, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29521642/assessment-of-16-month-sequelae-due-to-dog-bites-originally-studied-in-a-french-multicenter-survey-from-2009-to-2011
#7
Gaëlle Pédrono, Cécile Ricard, Marilyne Bouilly, Claude Béata, Guillaume Sarcey, Bertrand Thélot
INTRODUCTION: Every year in France dog bites lead to several thousand visits to emergency departments and numerous hospital admissions. OBJECTIVE: This study aims to describe the sequelae 16 months after dog bites. MATERIALS AND METHODS: Following an initial epidemiological study on the severity of 485 dog bites carried out in 8 hospital emergency departments between May 1, 2009, and June 30, 2010, a second study investigating sequelae 16 months after the bite was conducted among 298 patients between September 2010 and December 2011...
February 23, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718823/wound-bed-preparation-for-capsulectomy-using-a-hydrosurgery-system
#8
Yushi Suzuki, Masaki Yazawa, Kazuo Kishi
INTRODUCTION: Wound bed preparation is necessary for proper wound healing. CASE REPORT: The case of a 75-year-old man with good outcomes after using a hydrosurgery system for capsulectomy is presented. At a 2-month follow-up visit, a fistula measuring 15 cm x 10 cm was found to have developed in the patient's left scapular region after the first wide-excision surgery for soft tissue sarcoma and reconstruction of the defect using a local flap. The wound had fluid collection and a capsule that was then debrided with a hydrosurgery system...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718822/remote-temperature-monitoring-in-diabetic-foot-ulcer-detection
#9
Amanda L Killeen, Jodi L Walters
INTRODUCTION: Diabetic foot ulcers (DFUs) are associated with increased morbidity, mortality, and resource utilization. Remote temperature monitoring (RTM) is an evidence-based and recommended component of standard preventative foot care for high-risk populations that can detect the inflammation preceding and accompanying DFUs. OBJECTIVE: This case series illustrates the use of a RTM foot mat for the early detection and prevention of DFUs in patients with a history of DFUs...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718821/synergism-of-therapies-after-postoperative-autograft-failure-in-a-patient-with-melanoma-of-the-foot-misdiagnosed-as-a-pressure-ulcer
#10
Agata Janowska, Teresa Oranges, Andrea Chiricozzi, Marco Romanelli, Valentina Dini
INTRODUCTION: Amelanotic melanoma of the foot is a diagnostic challenge for physicians as it often appears as a benign lesion. In order to make the correct diagnosis at early stages, it is recommended to perform a biopsy of worsening lesions that are refractory to standard treatments, particularly nonhealing wounds. CASE REPORT: The authors describe the case of a 57-year-old man with amelanotic melanoma of the foot that had been treated as a pressure ulcer for 3 months...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718819/understanding-diabetic-induction-of-cellular-senescence-a-concise-review
#11
Matthew Regulski
OBJECTIVE: This study examines the healing dynamics of in vivo porcine muscle tissue wounds hemostatically treated with a saline-coupled bipolar tissue sealer (SCBS) compared with traditional electrosurgical (ES) coagulation. MATERIALS AND METHODS: Six cutaneous incisions were created on the dorsum of 28 adult male Yorkshire swine. The underlying muscle tissue was incised with a cold scalpel then treated with either SCBS (at 170 W) or traditional ES (at Coag 45 W)...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29718818/use-of-viable-cryopreserved-umbilical-tissue-for-soft-tissue-defects-in-patients-with-gas-gangrene-a-case-series
#12
Kristen McGinness, Dorothy H Kurtz Phelan
INTRODUCTION: Gas gangrene is a rapidly progressive bacterial infection leading to necrosis that usually develops as a result of trauma or postoperative complications. This condition requires early diagnosis with immediate surgical intervention. With a poor prognosis, a high incidence of amputation, and comorbidities such as diabetes and peripheral vascular disease, patients with gas gangrene are put at further risk for surgical complications. OBJECTIVE: This case series reports the clinical outcomes of using a commercially available viable cryopreserved umbilical tissue (vCUT) in the surgical management of 10 patients (9 males, 1 female) with acute lower extremity gas gangrene...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29521640/a-randomized-controlled-study-evaluating-the-clinical-benefits-of-a-cellulose-acetate-mesh-coated-with-a-soft-silicone-in-the-management-of-acute-wounds
#13
Anne-Claire Pierrefeu-Lagrange, Karine Mari, Caroline Hoss, Breda Cullen, Lorraine Nisbet
INTRODUCTION: Dressings are a mainstay for wound management; however, dressing adherence to the wound or periwound area can cause pain and trauma at removal. Dressing-related trauma includes skin reactions, adherence to the wound, and skin stripping. The development of atraumatic wound contact layer dressings has been a major advancement in reducing trauma. OBJECTIVE: This study compares the benefits of a cellulose acetate mesh (CAM) coated with soft silicone versus a flexible polyamide net (FPN) coated with soft silicone...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29521639/profile-and-antibiotic-susceptibility-of-bacteria-isolates-in-burn-patients-hospitalized-in-a-moroccan-hospital-a-cross-sectional-study
#14
Mohammed Frikh, Lemnouer Abdelhay, Kasouati Jalal, Yaagoubi Imad, Benlahlou Yassine, Belfquih Bouchra, Maleb Adil, Elouennass Mostafa
OBJECTIVE: The aim of this cross-sectional study is to assess the epidemiological profile and antibiotic susceptibility of bacteria isolates in burn patients hospitalized from 2007 to 2015 in a Moroccan hospital. MATERIALS AND METHODS: Of 627 samples, 451 wounds, 126 blood cultures, and 50 catheter samples were analyzed. A total of 610 microorganisms were isolated from a total of 108 patients. RESULTS: The most prevalent isolates were Pseudomonas aeruginosa (18...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29723142/use-of-a-novel-foam-dressing-with-negative-pressure-wound-therapy-and-instillation-recommendations-and-clinical-experience
#15
Paul J Kim, Andrew Applewhite, Anthony N Dardano, Luis Fernandez, Kimberly Hall, Elizabeth McElroy, Susan Mendez-Eastman, Marie Anne Obst, Casey Thomas, Lindsey Waddell, Garrett Wirth, Luc Téot
A new reticulated open-cell foam dressing with through holes (ROCF-CC) has been introduced to assist with wound cleansing by removing thick wound exudate and infectious materials during neg- ative pressure wound therapy with instillation. Due to the limited published evidence supporting use of ROCF-CC dressings with negative pressure wound therapy with instillation and dwell time (NPWTi-d), clinicians have been relying on practical application experience to gain pro ciency with the dressing and NPWTi-d. To help provide general guidelines for safe and e cient use of ROCF-CC dressings with NPWTi-d, a multidisciplinary expert panel of clinicians was convened from September 28 to 29, 2017...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29584608/utilization-of-a-viable-human-amnion-membrane-allograft-in-elderly-patients-with-chronic-lower-extremity-wounds-of-various-etiologies
#16
Matthew Regulski
ntroduction. Chronic nonhealing wounds are a growing health care problem in the United States, afflicting more than 6.5 million patients annually. In particular, diseases that compromise skin integrity and impair normal wound healing processes, such as diabetes and peripheral vascular diseases, are becoming more common in the aging population and leading to ever-increasing incidence of these chronic nonhealing wounds. OBJECTIVE: The aim of this study is to evaluate a viable human amnion membrane allograft (vHAMA) for the treatment of chronic nonhealing wounds in elderly patients (aged > 65 years) with multiple comorbidities...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29584607/calcinosis-cutis-and-negative-pressure-wound-therapy-as-adjuncts-to-surgical-management-case-report-and-review-of-the-literature
#17
Florian Radu, Masaru Nishiaoki, Martine A Louis
Calcinosis cutis (CC), or calcium deposition in soft tissue, can cause significant morbidity associated with arthralgias and ulceration. This condition has an elusive pathophysiology and is often associated with autoimmune disorders, significantly impacting the disease burden. The clinical presentation of CC varies, and there is no gold standard treatment modality. The case of a 50-year-old woman with scleroderma and a rare presentation of milky drainage of a left hip ulcer secondary to underlying CC that was treated successfully with surgery and negative pressure wound therapy is reported herein...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29584606/hereditary-sensory-and-autonomic-neuropathy-presenting-with-mutilating-trophic-ulcers
#18
Deepak Kumar Mathur, Chaitra Prakash, Puneet Bhargava, Vijay Paliwal, Kusum Mathur
Two siblings, a 19-year-old woman and an 18-year-old man, born to apparently normal parents of second-degree consanguineous marriage, presented to the Department of Dermatology, Sawai Man Singh Medical College Hospital, Jaipur, India, with recurrent skin ulcers of the hands and feet since early childhood. The ulcers were spontaneous, slow to heal, and caused deformities. On initial examination, they were found to have distal sensory loss, predominantly to pain and temperature. The patients were diagnosed with hereditary sensory and autonomic neuropathy of ulceromutilating type (Type 2) based on clinical evidences, nerve studies, and neuropathology...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29584605/evaluating-the-impact-of-a-patient-centered-remote-monitoring-program-on-adherence-to-negative-pressure-wound-therapy
#19
Leah Griffin, Laura Leyva Casillas
A remote therapy monitoring (RTM) system has been developed for use with a negative pressure wound therapy (NPWT) unit for patients in the home care setting. In conjunction with RTM, a network of trained professionals call patients when their NPWT usage is low and provide education to assist with therapy adherence. OBJECTIVE: The objective of this evaluation is to examine the relationship between the RTM system and patient adherence. MATERIALS AND METHODS: One hundred ninety-eight home care patients receiving NPWT with RTM between December 2016 and April 2017 were included...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29584604/do-not-limit-where-ulcer-debridements-can-be-performed
#20
Jeffrey D Lehrman
Medicare is a national program administered on a local level by Medicare Administrative Contractors (MACs). This brief report focuses on the potentially negative outcomes that may ensue as a result of MACs limiting the place of service for ulcer debridement. With the information included herein, the hope is that this problem can be addressed by all parties involved in wound care, including medical directors at these MACs, to remove this limitation impacting patient care.
March 2018: Wounds: a Compendium of Clinical Research and Practice
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