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Wounds: a Compendium of Clinical Research and Practice

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https://www.readbyqxmd.com/read/28862975/g-protein-coupled-receptors-and-proopiomelanocortin-expression-after-light-emitting-diode-irradiation-in-diabetic-wound-healing
#1
Muhammad Fairuz Azmi, Norzana Abd Ghafar, Jemaima Che Hamzah, Ng Sook Luan, Chua Kien Hui
OBJECTIVE: The purpose of this study is to investigate whether light-emitting diode (LED) light at different wavelengths can improve wound healing in both diabetic and normal fibroblasts. MATERIALS AND METHODS: Both diabetic and normal fibroblast cell lines were cultured and artificial wounds were created on the cultured cells in petri dishes as a streak line with pipette tips. Then, both cells were separately irradiated with 635 nm (red), 520 nm (green), and 465 nm (blue) LED lights at 0...
August 31, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28862974/clostridial-collagenase-for-the-management-of-diabetic-foot-ulcers-results-of-four-randomized-controlled-trials
#2
John C Lantis Ii, Ian Gordon
BACKGROUND: Despite major treatment advances, diabetic foot ulcers (DFUs) remain a frequent and debilitating complication of diabetes mellitus and a major cause of significant morbidity and mortality. OBJECTIVE: This study evaluates and compares clinical effectiveness of clostridial collagenase ointment (CCO) with standard care (SC) in patients with DFUs, with the goal to define best clinical criteria under which to use CCO in the DFU population. MATERIALS AND METHODS: This is a pooled data analysis of 4 randomized controlled trials that compared clinical effectiveness of CCO to SC...
August 25, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28873060/a-retrospective-crossover-study-of-the-use-of-aseptically-processed-placental-membrane-in-the-treatment-of-chronic-diabetic-foot-ulcers
#3
Lawrence A DiDomenico, Dennis P Orgill, Robert D Galiano, Thomas E Serena, Marissa J Carter, Jarrod P Kaufman, Nathan J Young, Charles M Zelen
BACKGROUND: In a recently published, prospective randomized controlled trial (RCT) comparing aseptically processed dehydrated human amnion/chorion allograft (dHACA) to standard of care (SOC), 85% wound closure rates were reported in the dHACA arm while only 25% of patients in the SOC arm healed. OBJECTIVE: The purpose of this retrospective crossover study is to evaluate the effectiveness of dHACA in those patients that failed to respond to the SOC treatments and who exited the original study after failing up to 12 weeks of SOC treatment...
July 26, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28873059/traction-assisted-internal-negative-pressure-wound-therapy-with-bridging-retention-sutures-to-facilitate-staged-closure-of-high-risk-wounds-under-tension
#4
Michael V DeFazio, James M Economides, Ersilia L Anghel, Ryan K Mathis, John R Barbour, Christopher E Attinger
BACKGROUND/OBJECTIVE: Loss of domain often complicates attempts at delayed wound closure in regions of high tension. Wound temporization with traction-assisted internal negative pressure wound therapy (NPWT), using bridging retention sutures, can minimize the effects of edema and elastic recoil that contribute to progressive tissue retraction over time. The investigators evaluated the safety and efficacy of this technique for complex wound closure. MATERIALS AND METHODS: Between May 2015 and November 2015, 18 consecutive patients underwent staged reconstruction of complex and/or contaminated soft tissue defects utilizing either conventional NPWT or modified NPWT with instillation and continuous dermatotraction via bridging retention sutures...
July 26, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28678732/does-fine-needle-aspiration-microbiology-offer-any-benefit-over-wound-swab-in-detecting-the-causative-organisms-in-surgical-site-infections
#5
Sundaramurthi Sudharsanan, Sreenath Gs, Sathasivam Sureshkumar, Chellappa Vijayakumar, Sistla Sujatha, Vikram Kate
OBJECTIVE: The objective of this study is to determine the role of ne needle aspiration microbiology (FNAM) in detecting the causative organisms of postoperative surgical site infections (SSIs) in comparison with the standard technique of surface swabbing. Ma- terials and Methods. In this study, 150 patients with SSIs following elective and emergency operations were included. In all patients, FNAM was performed along with conventional surface swabbing to identify the causative microorganism...
June 28, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28678731/the-potential-of-gelam-honey-in-promoting-the-proliferative-phase-of-corneal-reepithelialization
#6
Muhammad Fairuz Azmi, Norzana Abd Ghafar, Jemaima Che Hamzah, Ng Sook Luan, Chua Kien Hui
OBJECTIVE: The aim of this study is to investigate the potential bene ts of Gelam honey (GH) in promoting proliferation of ex vivo cor- neal epithelial cells (CECs) and its effects on the phenotypical features. MATERIALS AND METHODS: Corneal epithelial cells were isolated from the corneas of rabbits (n = 6). The optimal dose of GH for CEC proliferation in both basal medium (BM) and cornea medium (CM) was determined via MTT (3-[4, 5-dimethyl thiazolyl-2]-2, 5-diphenyl tetrazolium bro- mide) assay...
June 28, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28678730/comprehensive-in-situ-killing-of-six-common-wound-pathogens-with-manuka-honey-dressings-using-a-modified-aatcc-tm100
#7
Denis Watson, Stephen Bergquist, Julie Nicholson, David H Norrie
OBJECTIVE: While Manuka honey in vitro is strongly antimicrobial, there have been, to the best of the authors' knowledge, no studies showing that dressings impregnated with Manuka honey can kill organisms in the dressing itself. MATERIALS AND METHODS: The investigators used the American Association of Textile Chemists and Colorists' 100 test methodology to compare honey-impregnated dressings with control dressings (without honey) on the ability to kill common wound pathogens...
June 28, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28862980/management-of-chronic-wounds-diagnosis-preparation-treatment-and-follow-up
#8
Subhas Gupta, Charles Andersen, Joyce Black, Jean de Leon, Caroline Fife, John C Lantis Ii, Jeffrey Niezgoda, Robert Snyder, Bauer Sumpio, William Tettelbach, Terry Treadwell, Dot Weir, Ronald P Silverman
Management of chronic wounds remains challenging in terms of prevalence and complexity. Considerable progress has been made in understanding the science of wound healing during the past decade, sparking volumes of publications and the development of hundreds of dressing and therapy options. There is a need for a simpli ed overview of evidence-based criteria to assist in the accurate diagnosis and appropriate management of chronic wounds in all care settings. An expert panel of 11 wound healing specialists experienced in various care settings convened to discuss best practices and recommended guidelines for managing major chronic wound types...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28862979/negative-pressure-wound-therapy-for-a-giant-wound-secondary-to-malignancy-induced-necrotizing-fasciitis-case-report-and-review-of-the-literature
#9
Jiayi Hu, Serge Goekjian, Nicolas Stone, Alexandra Nelson, Michael James Cooper
BACKGROUND: Necrotizing fasciitis (NF) is a life-threatening condition in which rapid diagnosis, debridement of nonviable tissue, and broad-spectrum antibiotics are critical to effective treatment. The debridement required can be extensive, resulting in large wounds that can sometimes be covered with split-thickness skin grafts (STSGs) with the help of negative pressure wound therapy (NPWT), or vacuum-assisted closure, to decrease the wound size. CASE REPORT: The authors report a rare case of NF due to malignancy-associated bowel perforation with a giant lower extremity wound secondary to debridement that involved 20% of the total body surface area (TBSA) in a 64-year-old, previously healthy, nonsmoking man...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28862978/editorial-message-sometimes-it-just-has-to-be-done
#10
Terry Treadwell
No abstract text is available yet for this article.
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28862977/healing-rate-of-chronic-and-subacute-lower-extremity-ulcers-treated-with-contact-ultrasound-followed-by-noncontact-ultrasound-therapy-the-vip-ultrasound-protocol
#11
Lisley Viana, Matthew Pompeo
BACKGROUND: Contact and noncontact ultrasounds are types of low-frequency ultrasonic treatments for wound care. OBJECTIVE: The purpose of this research was to collect data in order to see if healing rates are accelerated when both forms of ultrasound therapies are utilized. MATERIALS AND METHODS: The Viana-Pompeo (VIP) Ultrasound Protocol consists of high-intensity, low-frequency, contact ultrasound therapy followed by low-intensity, low-frequency, noncontact ultrasound therapy...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28862976/sarcoidosis-and-wound-healing-after-cellulitis-of-the-lower-limb-is-methotrexate-responsible-for-skin-graft-failure
#12
Sonia Gaucher, Claire Nicolas, Olivier Piveteau, Henri-Jean Philippe, Philippe Blanche
The authors report the case of a 53-year-old man with diffuse cutaneous and mediastinal pulmonary sarcoidosis and well-controlled steroid-induced diabetes. He was hospitalized for cellulitis of his left leg. His standard treatment for sarcoidosis consisted of prednisone and methotrexate. Prednisone was stopped at his admission. He received antibiotics for 4 weeks to treat the cellulitis. In parallel, the leg wound was treated with daily silver sulfadiazine applications until necrosis removal, then by skin autografting...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28570251/effectiveness-of-changing-the-application-of-japanese-honey-to-a-hydrocolloid-dressing-in-between-the-inflammatory-and-proliferative-phases-on-cutaneous-wound-healing-in-male-mice
#13
Olga O Bilyayeva, Viacheslav V Neshta, Alexander A Golub, Frank Sams-Dood
OBJECTIVE: The purpose of this study was to determine the wound healing effects of Acapsil, a white, odorless powder based on micropore particle technology (MPPT) (Willingsford Ltd, Southampton, UK) by comparing it to Gentaxane (Gentaksan, Borshchagovsky CCP, Kyiv, Ukraine) (polydimethylsiloxane powder with gentamicin antibiotic) and Ioddicerin (Farmak, Kyiv, Ukraine) (iodine with dimethyl sulfoxide [DMSO]). MATERIALS AND METHODS: The study included 266 patients with primarily trophic ulcers caused by pancreatic diabetes and venous insufficiency of the lower extremities, carbuncles, phlegmons, infected third- or fourth-degree heat burns, and infiltrations of postoperative wounds...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28570250/effect-of-negative-pressure-wound-therapy-with-instillation-on-bioburden-in-chronically-infected-wounds
#14
Chun Yang, Selena G Goss, Sean Alcantara, Greg Schultz, John C Lantis Ii
INTRODUCTION: Standard negative pressure wound therapy (NPWT) has been shown to help close wounds despite increasing planktonic bioburden. Both planktonic and biofilm critical colonization are associated with delayed wound healing; therefore, reducing microbial colonization is thought to aid wound healing. The use of NPWT with topical antimicrobial irrigation solution has previously shown reduction in quantitative planktonic bioburden when combined with sharp debridement in chronic wounds...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28570249/early-detection-of-pressure-injury-using-a-forensic-alternate-light-source
#15
Heather Hettrick, Cheryl Hill, Patrick Hardigan
OBJECTIVE: This study aimed to determine if an alternate light source (ALS) can be used to detect tissue trauma before visible manifestations of tissue injury are evident with the naked eye. MATERIALS AND METHODS: Ten participants were recruited and gave consent, and 7 completed the study. Researchers examined and photographed participants' heels in ambient light to establish baseline. A series of photographs using ALS and camera were taken as follows: violet wavelength at 415 nm to 445 nm with yellow lens; blue wavelength at 455 nm to 515 nm with orange lens; and green wavelength at 535 nm to 575 nm with red lens...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28762948/previous-atorvastatin-treatment-and-risk-of-diabetic-foot-infection-in-adult-patients-a-case-control-study
#16
Mohammad Nassaji, Raheb Ghorbani, Hanieh Saboori Shkofte
OBJECTIVE: In addition to their lipid-lowering abilities, statins have anti-inflammatory and immunomodulatory properties. Increasing recent evidence suggests the possible role of pretreatment with statins in preventing or decreasing morbidity and mortality from infection. Diabetic foot infection (DFI) is a common complication of diabetes mellitus. The aim of this study was to determine whether previous atorvastatin use is associated with reduced risk of DFI and better outcomes of these infections...
July 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28759431/venous-ulcers-treated-with-a-hyaluronic-acid-extracellular-matrix-and-compression-therapy-interim-analysis-of-a-randomized-controlled-trial
#17
Oscar M Alvarez, Lee Makowitz, Mayank Patel
Diabetic foot ulcers (DFUs) are a severe and costly complication of diabetes and may result in foot amputation. CASE REPORT: A 69-year-old man with a 10-year history of type 2 diabetes, who was undergoing routine care for diabetes in the authors' clinic, developed a DFU of his right foot of 4 years' duration. The wound did not respond to conventional treatments, and imaging studies were normal. His 2 biopsies tested negative for malignancy. The DFU was fully removed surgically. Following surgical removal, squamous cell carcinoma (SCC) was diagnosed in the histologic study of the wound...
July 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28759430/squamous-cell-carcinoma-arising-in-a-chronic-nonhealing-diabetic-foot-ulcer
#18
Bagher Larijani, Seyed Mohammad Tavangar, Fatemeh Bandarian
Diabetic foot ulcers (DFUs) are a severe and costly complication of diabetes and may result in foot amputation. CASE REPORT: A 69-year-old man with a 10-year history of type 2 diabetes, who was undergoing routine care for diabetes in the authors' clinic, developed a DFU of his right foot of 4 years' duration. The wound did not respond to conventional treatments, and imaging studies were normal. His 2 biopsies tested negative for malignancy. The DFU was fully removed surgically. Following surgical removal, squamous cell carcinoma (SCC) was diagnosed in the histologic study of the wound...
July 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28759429/serial-surgical-debridement-of-common-pressure-injuries-in-the-nursing-home-setting-outcomes-and-findings
#19
Bardia Anvar, Henry Okonkwo
OBJECTIVE: This study examined the efficacy of bedside surgical debridement in a nursing home population. MATERIALS AND METHODS: A retrospective chart review was performed of sacrum, sacrococcyx, coccyx, ischium, and trochanter (SSCIT) region pressure injuries in the Skilled Wound Care practice (Los Angeles, CA). The patient population was refined from 2128 to 227 patients visited 8 or more times during nursing home stays found to have 1 or more SSCIT pressure injuries...
July 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28759428/negative-pressure-wound-therapy-for-patients-with-complex-abdominal-wounds
#20
Ahmet Bilgi, Fazilet Zumrut Biber Muftuler, Levent Akman, Emin Ilker Medine, Pinar Tonbaklar Bilgi, Ozge Kozgus Guldu, Sevki Goksun Gokulu, Volkan Tekin, Mustafa Cosan Terek
BACKGROUND: Research on treatment alternatives that improve wound healing is an ever-evolving area in medicine, and a wound healing agent that carries minimal pain, discomfort, and scarring for patients with burn wounds, venous and decubitis ulcers, traumatic wounds, and many others is needed. The phases of wound healing include homeostasis, inflammation, migration, proliferation, and maturation. Adeps suillus (axonge) is known as a therapeutic agent for skin diseases and mainly consists of triglycerides...
July 2017: Wounds: a Compendium of Clinical Research and Practice
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