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Wounds: a Compendium of Clinical Research and Practice

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https://www.readbyqxmd.com/read/28267679/the-effect-of-silver-coated-dressing-on-pain-management-and-hospitalization-duration-in-pediatric-partial-thickness-burns-a-retrospective-matched-cohort-study
#1
Itay Wiser, Ophir Schein, Julietta D Rubin, Roni Averbuch Sagie, Iris Reshef, Adi Lotan, Avshalom Shalom
OBJECTIVE: Daily burn wound dressing protocols elicit pain and anxiety, especially in pediatric burn patients. Novel dressing technologies reduce pain by obviating the need for frequent dressing changes. The objective of this study was to assess the effect of silver-coated dressings (SCDs) on pain management and outcomes in pediatric burn patients. MATERIALS AND METHODS: A retrospective, matched cohort study compared a SCD to standard dressing protocols in admitted pediatric burn patients...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28267678/enzymatic-debridement-of-chronic-nonischemic-diabetic-foot-ulcers-results-of-a-randomized-controlled-trial
#2
Juan Carlos Jimenez, Patrick S Agnew, Perry Mayer, John R Clements, Joseph M Caporusso, Darrell L Lange, Jaime E Dickerson, Herbert B Slade
OBJECTIVE: The aim of this randomized, controlled multicenter trial was to evaluate the clinical outcomes associated with the use of clostridial collagenase ointment (CCO) for up to 12 weeks in 215 patients with type 1 or type 2 diabetes mellitus and a neuropathic, nonischemic diabetic foot ulcer (DFU). MATERIALS AND METHODS: Patients were randomized into either a group receiving CCO applied once daily at a thickness of ~2 mm or a group receiving standard care (SC) consisting of a daily application of a hydrogel as needed to maintain a moist ulcer environment...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28267677/diabetic-foot-ulcers-treated-with-porcine-urinary-bladder-extracellular-matrix-and-total-contact-cast-interim-analysis-of-a-randomized-controlled-trial
#3
Oscar M Alvarez, Tashara Smith, Thomas W Gilbert, Neh J Onumah, Martin E Wendelken, Rachelle Parker, Lee Markowitz
OBJECTIVE: To evaluate the effectiveness of a porcine urinary bladder-derived extracellular matrix (UBM) for the treatment of recalcitrant, neuropathic diabetic foot ulcers (DFUs). MATERIALS AND METHODS: This prospective, parallel, randomized, single-center study involving 17 subjects was performed in an outpatient wound care center setting. Each subject with a DFU was randomized (2:1) to receive the urinary bladder matrix (UBM) plus offloading with a total contact cast (TCC) or standard care (nonadherent dressing plus TCC)...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28135202/using-a-radial-diffusion-method-to-investigate-the-role-of-plasmin-degradation-of-fibrin-in-a-physical-model-of-an-early-phase-wound
#4
Chima P Chukwuemeka, Jann Cupp, Jonathan R Sanders
BACKGROUND: Fibrin clot formation, which acts to stabilize a wound following injury, is among the key early aspects of dermal wound healing. This preliminary matrix is eventually degraded via a process known as fibrinolysis and replaced with a collagen-rich matrix that continues to be remodeled to minimize scarring. Disruptions in these carefully coordinated events lead to certain undesirable conditions such as fibrosis and the formation of abnormal scars that are associated with excess amounts of collagen...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28135201/use-of-a-dehydrated-amniotic-membrane-allograft-in-the-treatment-of-lower-extremity-wounds-a-retrospective-cohort-study
#5
Eric J Lullove
Injuries to the skin are extensively costly to the health care system. When caused by metabolic and vascular compromise, these injuries are even more foreboding for patients. They can result in chronic inflammation, reduced mobility, and chronic pain. MATERIALS AND METHODS: Twenty patients were selected from the author's patient population at the West Boca Center for Wound Healing for a retrospective cohort study. Patients underwent a run-in period of 2 weeks, where standard of care was used to clear the wound of bioburden...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28135200/evaluating-the-effect-of-3-papain-gel-application-in-cutaneous-wound-healing-in-mice
#6
Flávia Figueiredo Azevedo, Letícia P Santanna, Vanessa C Bóbbo, Edson A Libert, Eliana P Araújo, Mário Abdalla Saad, Maria Helena M Lima
While the US Food and Drug Administration has not approved the use of 3% papain gel in the United States, the authors feel this study adds to the literature regarding its use. INTRODUCTION: The aim of this study was to evaluate the effect of 3% papain gel on wounds in mice. MATERIALS AND METHODS: Thirty healthy C57BL mice (25-30 g) aged 10 weeks were randomly divided into 2 groups: mice treated with 3% papain gel and mice treated with placebo gel. Skin incisions were performed with a 6-mm metallic punch with a cutting blade edge...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272017/effects-of-hypericum-perforatum-on-an-experimentally-induced-diabetic-wound-in-a-rat-model
#7
Mehmet Farsak, Görkemo Özdağli, Doğay Özmüş, Ülkü Çömelekoğlu, Serap Yalın, Rabia Bozdoğan Arpacı, Ramazan Gen, Arzu Kanık, Derya Ümit Talas
OBJECTIVE: The aim of this study was to investigate the probable effects of Hypericum perforatum (HP) on wound healing in diabetic rats. MATERIALS AND METHODS: Thirty-five male Wistar rats were divided evenly into 5 groups. Diabetes formation was induced by intraperitoneal streptozotocin (60 mg/kg) administration for groups 1 (HP extract in olive oil), 2 (HP extract in ethanol), 3 (povidone-iodine application), and 4 (diabetic rats without any applied medication); group 5 was the control...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272016/cactus-spine-wounds-a-case-report-and-short-review-of-the-literature
#8
Raymond A Dieter, Lisa R Whitehouse, Rebecca Gulliver
INTRODUCTION: Cactus plants are commonly seen in arid southwestern regions of the United States. Due to their ready availability, they have become a popular houseplant. The spines or glochidia can easily puncture the skin with only minor pressure (ie, bumping or touching the cactus). Removal of the offending spine is difficult, even with tweezers. CASE: An 18-year-old woman initially self-removed the spines, and marked discomfort and intense erythematous reaction developed within 8 to 10 hours...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272015/evidence-corner-diagnosing-diabetic-foot-osteomyelitis
#9
Laura Bolton
No abstract text is available yet for this article.
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272014/the-potential-role-of-zinc-supplementation-on-pressure-injury-healing-in-older-adults-a-review-of-the-literature
#10
Melissa Heintschel, Roschelle Heuberger
INTRODUCTION: Compromised nutritional status is common among older adults (aged ≥ 65 years) and is a risk factor for pressure injuries (PIs), which may lead to poor clinical outcomes. The aim of this review was to determine whether or not poor PI healing in older adults is a result of suboptimal zinc status. METHODS: A literature search was performed in PubMed from 2001 to 2016 using the key words: "zinc status," "pressure ulcer," "pressure ulcers in older adults," "wound healing," and "zinc sulfate...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272013/when-traditional-offloading-is-not-an-option-could-an-external-fixator-be-a-solution-a-case-report
#11
Abdulaziz A Kimawi, Robert J Snyder, Mario A Cala, Cherison Cuffy
Offloading is a cornerstone in managing diabetic plantar foot ulcers; however, it often represents one of the most challenging aspects of treatment for clinician and patient alike. The authors present a case of a 61-year-old African American man with type 2 diabetes and a limb-threatening plantar foot ulcer that required aggressive wound and surgical management. Due to the heavy drainage and patient adherence issues, traditional offloading techniques such as total contact cast, DH Pressure Relief Walker (Össur, Foothill Ranch, CA), and wedge shoes, among others, were not viable options...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272012/accuracy-of-the-ankle-brachial-index-in-the-assessment-of-arterial-perfusion-of-heel-pressure-injuries
#12
Amanda Crowell, Andrew J Meyr
BACKGROUND: The evaluation and treatment of heel pressure injuries are a significant and expensive sequela of the aging population. Although the workup of patients with lower extremity tissue loss usually involves an assessment of the arterial blood flow by means of noninvasive vascular testing, the results may be misleading in patients with heel pressure injuries when the ankle-brachial index (ABI) does not provide direct information about perfusion of the rearfoot. The objective of this retrospective, observational investigation was to determine if noninvasive vascular testing provides accurate and reliable results in patients with heel pressure injuries...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272011/human-reticular-acellular-dermal-matrix-in-the-healing-of-chronic-diabetic-foot-ulcerations-that-failed-standard-conservative-treatment-a-retrospective-crossover-study
#13
Charles M Zelen, Dennis P Orgill, Thomas E Serena, Robert D Galiano, Marissa J Carter, Lawrence A DiDomenico, Jarrod P Kaufman, Jennifer Keller, Nathan J Young, William W Li
BACKGROUND: Acellular matrices have been successfully used to heal indolent diabetic foot ulcers (DFUs). These tissues include allogenic dermis as well as xenograft dermis, pericardium, and small intestine submucosa. While all of these tissues show promise for healing DFUs, dermal-derived matrices have shown considerable potential. MATERIALS AND METHODS: The authors retrospectively reviewed healing in patients with DFUs that failed the standard of care (SOC) treatment from a previous prospective randomized, controlled trial (RCT)...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272010/the-use-of-a-sea-salt-based-spray-for-diabetic-foot-ulcers-a-novel-concept
#14
David A Pougatsch, Andrew Rader, Lee C Rogers
Several patients present to wound healing specialists seeking a natural or alternative medical approach to their wounds. The purpose of this prospective, case-cohort study of 10 patients was to evaluate the use of Oceanzyme Wound Care Spray (Ocean Aid, Inc, Boynton Beach, FL) in improving healing in diabetic foot ulcers during a 12-week period. This product contains water purified by reverse osmosis, coral reef sea salt, lysozyme, and sodium benzoate. The primary endpoint was wound closure, and secondary endpoints were infection rate and wound area reduction...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28157687/unusual-behavior-of-a-posttraumatic-scar-craniofacial-actinomycosis
#15
Ritesh Panda, Vivek Kumar, Shiv Shankar Saha, Lalit Choudhary, Anurag Pandey
Actinomycosis is a chronic suppurative granulomatous infection most commonly involving the cervicofacial region. Clinical diagnosis is usually difficult, and fine-needle aspiration cytology or imaging studies are usually unhelpful in diagnosing actinomycosis. Definitive diagnosis is based on the histopathological examination of a tissue biopsy. The authors report a case of a 32-year-old healthy man who underwent multiple surgeries over a period of 7 years to correct a posttraumatic scar on his forehead with unusual behavior...
January 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28157686/mesenchymal-stem-cells-guardians-of-inflammation
#16
Matthew J Regulski
Human mesenchymal stem cells (MSCs) are a unique progenitor cell that can be recovered from most vascularized tissues in the human body. In addition to their capability of differentiating into tissues of mesenchymal lineage, perhaps their most salient features are immunomodulation and trophic capabilities. A chronic wound is characterized by an overzealous immune response that leads to a corrosive extracellular matrix, deficiency of regulatory growth factors, hypoxia, and cellular senescence. Human MSCs are a potential therapeutic modality to recapitulate the healing paradigm through their capacity to modulate both the innate and the adaptive immune responses...
January 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28157685/facial-actinomycosis-mimicking-a-cutaneous-tumor
#17
Adem Özkan, Adem Topkara, Ramazan Hakan Özcan
Actinomycosis is a chronic granulomatous infection that commonly occurs in the cervicofacial region. Although Actinomcyes is an element of the normal oral flora, infections of the facial skin are very rare because of the entirely endogenous habitation of the organism. The authors report a case of facial actinomycosis, which mimicked a cutaneous tumor both clinically and surgically in a 44-year-old woman with chronic renal failure and Hepatitis C viral infection. The majority of cases can be treated with long-term antibiotics...
January 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054922/evaluating-the-use-of-hematological-parameters-in-staging-hidradenitis-suppurativa
#18
Necdet Fatih Yaşar, Mustafa Ufuk Uylas, Mustafa Baspinar, Hakan Sarsilmaz, Ersin Ates, Serdar Erkasap, Adnan Sahin
INTRODUCTION: Recently, it has been shown that hematological parameters may be used as markers of inflammatory response. In this study, the authors aimed to identify the potential roles of the neutrophil-lymphocyte ratio (NLR) and other hematological markers in the evaluation of hidradenitis suppurativa (HS), a chronic, recurrent inflammatory disease. MATERIALS AND METHODS: A total of 35 patients, diagnosed with HS between January 1, 2012 and December 31, 2014, were categorized into 3 groups according to the Hurley staging system...
December 29, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054921/evaluation-of-the-effects-of-air-pollutants-on-diabetic-wounds
#19
Young Suk Choi, Il-Hoon Sung, Ji Yun Lim, A Hyun Kyun, Eui Dong Yeo, Sun Geun Lee, Young Koo Lee
BACKGROUND: Although air pollution containing fine dust particles is gaining attention worldwide, little is known about the effects of such pollutants on diabetic wounds. Air pollutants from diesel exhaust particles (DEPs) cause inflammation, resulting in an increased expression of pro-inflammatory cytokines and chemo- kines, which attract monocytes and T cells to the sites of inflamma- tion. The authors evaluated the effects of air pollutants on diabetic wounds. MATERIALS AND METHODS: Fibroblast cells were derived from streptozotocin-induced diabetic rats...
December 29, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054920/evaluation-of-honey-as-a-topical-therapy-for-intraoral-wound-healing-in-rats
#20
Goli Chamani, Mohammad Reza Zarei, Mitra Mehrabani, Ali Mehdavinezhad, Mehrangiz Vahabian, Fatemah Ahmadi-Motamayel
OBJECTIVE: Honey is one of the oldest known medicines. Its medical and therapeutic importance has been recently rediscovered. Honey is an effective treatment for infected wounds and ulcers. The aim of this study was to determine the effect of honey as a topical therapy for intraoral wound healing in rats. MATERIALS AND METHODS: Thirty-two male rats were divided into experimental and control groups (consisting of 16 rats, 4 animals in each group). A 2-mm mucosal defect was made to the depth of the periosteum using punch biopsy...
December 29, 2016: Wounds: a Compendium of Clinical Research and Practice
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