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Wounds: a Compendium of Clinical Research and Practice

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https://www.readbyqxmd.com/read/28135202/using-a-radial-diffusion-method-to-investigate-the-role-of-plasmin-degradation-of-fibrin-in-a-physical-model-of-an-early-phase-wound
#1
Chima P Chukwuemeka, Jann Cupp, Jonathan R Sanders
BACKGROUND: Fibrin clot formation, which acts to stabilize a wound following injury, is among the key early aspects of dermal wound healing. This preliminary matrix is eventually degraded via a process known as fibrinolysis and replaced with a collagen-rich matrix that continues to be remodeled to minimize scarring. Disruptions in these carefully coordinated events lead to certain undesirable conditions such as fibrosis and the formation of abnormal scars that are associated with excess amounts of collagen...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28135201/use-of-a-dehydrated-amniotic-membrane-allograft-in-the-treatment-of-lower-extremity-wounds-a-retrospective-cohort-study
#2
Eric J Lullove
: Injuries to the skin are extensively costly to the health care system. When caused by metabolic and vascular compromise, these injuries are even more foreboding for patients. They can result in chronic inflammation, reduced mobility, and chronic pain. MATERIALS AND METHODS: Twenty patients were selected from the author's patient population at the West Boca Center for Wound Healing for a retrospective cohort study. Patients underwent a run-in period of 2 weeks, where standard of care was used to clear the wound of bioburden...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28135200/evaluating-the-effect-of-3-papain-gel-application-in-cutaneous-wound-healing-in-mice
#3
Flávia Figueiredo Azevedo, Letícia P Santanna, Vanessa C Bóbbo, Edson A Libert, Eliana P Araújo, Mário Abdalla Saad, Maria Helena M Lima
: While the US Food and Drug Administration has not approved the use of 3% papain gel in the United States, the authors feel this study adds to the literature regarding its use. INTRODUCTION: The aim of this study was to evaluate the effect of 3% papain gel on wounds in mice. MATERIALS AND METHODS: Thirty healthy C57BL mice (25-30 g) aged 10 weeks were randomly divided into 2 groups: mice treated with 3% papain gel and mice treated with placebo gel...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054922/evaluating-the-use-of-hematological-parameters-in-staging-hidradenitis-suppurativa
#4
Necdet Fatih Yaşar, Mustafa Ufuk Uylas, Mustafa Baspinar, Hakan Sarsilmaz, Ersin Ates, Serdar Erkasap, Adnan Sahin
INTRODUCTION: Recently, it has been shown that hematological parameters may be used as markers of inflammatory response. In this study, the authors aimed to identify the potential roles of the neutrophil-lymphocyte ratio (NLR) and other hematological markers in the evaluation of hidradenitis suppurativa (HS), a chronic, recurrent inflammatory disease. MATERIALS AND METHODS: A total of 35 patients, diagnosed with HS between January 1, 2012 and December 31, 2014, were categorized into 3 groups according to the Hurley staging system...
December 29, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054921/evaluation-of-the-effects-of-air-pollutants-on-diabetic-wounds
#5
Young Suk Choi, Il-Hoon Sung, Ji Yun Lim, A Hyun Kyun, Eui Dong Yeo, Sun Geun Lee, Young Koo Lee
BACKGROUND: Although air pollution containing fine dust particles is gaining attention worldwide, little is known about the effects of such pollutants on diabetic wounds. Air pollutants from diesel exhaust particles (DEPs) cause inflammation, resulting in an increased expression of pro-inflammatory cytokines and chemo- kines, which attract monocytes and T cells to the sites of inflamma- tion. The authors evaluated the effects of air pollutants on diabetic wounds. MATERIALS AND METHODS: Fibroblast cells were derived from streptozotocin-induced diabetic rats...
December 29, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054920/evaluation-of-honey-as-a-topical-therapy-for-intraoral-wound-healing-in-rats
#6
Goli Chamani, Mohammad Reza Zarei, Mitra Mehrabani, Ali Mehdavinezhad, Mehrangiz Vahabian, Fatemah Ahmadi-Motamayel
OBJECTIVE: Honey is one of the oldest known medicines. Its medical and therapeutic importance has been recently rediscovered. Honey is an effective treatment for infected wounds and ulcers. The aim of this study was to determine the effect of honey as a topical therapy for intraoral wound healing in rats. MATERIALS AND METHODS: Thirty-two male rats were divided into experimental and control groups (consisting of 16 rats, 4 animals in each group). A 2-mm mucosal defect was made to the depth of the periosteum using punch biopsy...
December 29, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28157687/unusual-behavior-of-a-posttraumatic-scar-craniofacial-actinomycosis
#7
Ritesh Panda, Vivek Kumar, Shiv Shankar Saha, Lalit Choudhary, Anurag Pandey
Actinomycosis is a chronic suppurative granulomatous infection most commonly involving the cervicofacial region. Clinical diagnosis is usually difficult, and fine-needle aspiration cytology or imaging studies are usually unhelpful in diagnosing actinomycosis. Definitive diagnosis is based on the histopathological examination of a tissue biopsy. The authors report a case of a 32-year-old healthy man who underwent multiple surgeries over a period of 7 years to correct a posttraumatic scar on his forehead with unusual behavior...
January 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28157686/mesenchymal-stem-cells-guardians-of-inflammation
#8
Matthew J Regulski
Human mesenchymal stem cells (MSCs) are a unique progenitor cell that can be recovered from most vascularized tissues in the human body. In addition to their capability of differentiating into tissues of mesenchymal lineage, perhaps their most salient features are immunomodulation and trophic capabilities. A chronic wound is characterized by an overzealous immune response that leads to a corrosive extracellular matrix, deficiency of regulatory growth factors, hypoxia, and cellular senescence. Human MSCs are a potential therapeutic modality to recapitulate the healing paradigm through their capacity to modulate both the innate and the adaptive immune responses...
January 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28157685/facial-actinomycosis-mimicking-a-cutaneous-tumor
#9
Adem Özkan, Adem Topkara, Ramazan Hakan Özcan
Actinomycosis is a chronic granulomatous infection that commonly occurs in the cervicofacial region. Although Actinomcyes is an element of the normal oral flora, infections of the facial skin are very rare because of the entirely endogenous habitation of the organism. The authors report a case of facial actinomycosis, which mimicked a cutaneous tumor both clinically and surgically in a 44-year-old woman with chronic renal failure and Hepatitis C viral infection. The majority of cases can be treated with long-term antibiotics...
January 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054930/cyanoacrylate-burn-injuries-two-unusual-cases-and-a-review-of-the-literature
#10
Christian P Eyth, Kezia Echlin, Isabel Jones
The authors present 2 cases of cyanoacrylate glue ("Super Glue") burns, with a review of the literature and a discussion on the mechanism of action. The authors found all reported cases were with domestic - not medical-grade - cyanoacrylate glue in the presence of cotton fabric. Often erroneously designated as chemical burns, they are thermal burns caused by an intensive exothermic reaction. Cotton acts as a highly potent catalyst, speeding up the polymerization reaction leading to high-peak temperatures capable of causing burns and spontaneous ignition of the fabric...
December 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054929/rare-complication-of-stomas-peristomal-necrotizing-fasciitis
#11
Kivanc Derya Peker, Burak M Ilhan
INTRODUCTION: A stoma formation is a frequently performed procedure in patients undergoing colorectal surgery. Although stoma formation is a simple process, it should be performed with caution. The aim of this study was to attract physicians' attention to this rare disease and also to identify the surgical and medical treatment options for peristomal necrotizing fasciitis as a rare complication. MATERIALS AND METHODS: Risk factors including age, sex, additional diseases, previous surgical procedures, source of infection, physical findings, and vital signs of 14 patients with peristomal necrotizing fasciitis over a period of 10 years from 2005 to 2015 were retrospectively evaluated...
December 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054928/editorial-message-making-it-christmas-every-day
#12
Terry Treadwell
No abstract text is available yet for this article.
December 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054927/evidence-corner-patient-centered-issues-affect-surgical-outcomes
#13
Laura Bolton
No abstract text is available yet for this article.
December 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28054926/a-literature-review-of-burns-in-reconstructed-breasts-after-mastectomy
#14
Marie Jaeger, Yonathan Wagman, Alon Liran, Moti Harats, Eyal Winkler, Josef Haik, Ariel Tessone
OBJECTIVE: The goal of this literature review is to review and combine case studies of accidental burns to the breast, following mastectomy and immediate breast reconstruction with autologous tissue, implants, or tissue expanders. METHODS: The authors searched PubMed and Cochrane Library and reviewed cases of burns of reconstructed breasts after mastectomy from July 1985 to May 2015. Only studies in the English language were included in their search. They also report 5 new cases of burns in patients with burns to the breast, which were either reconstructed with implants or tissue expanders at Sheba Medical Center (Ramat Gan, Israel)...
December 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27861134/myiasis-of-the-toe-as-a-complication-of-a-neglected-wound-a-case-report
#15
Sevliya Öcal Demir, Ahmet Soysal, Gülşen Akkoç, Eda Kepenekli Kadayifci, Nurhayat Yakut, Nilgün Çerikçioğlu, Mustafa Bakir
No abstract text is available yet for this article.
November 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27861133/letter-to-the-editor-intraosseous-approach-to-treat-osteomyelitis-and-to-monitor-oxygen-levels-during-hyperbaric-treatment
#16
Alan Coulson
No abstract text is available yet for this article.
November 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27861132/chronic-morel-lavall%C3%A3-e-lesion-a-novel-minimally-invasive-method-of-treatment
#17
Ramireddy Mettu, Harsha Vardhan Surath, Hanumantha Rao Chayam, Amaranth Surath
A Morel-Lavallée lesion is a closed internal degloving injury resulting from a shearing force applied to the skin. The etiology of this condition may be motor vehicle accidents, falls, contact sports (ie, football, wrestling),1 and iatrogenic after mammoplasty or abdominal liposuction.2 Common sites of the lesions include the pelvis and/or thigh.3 Isolated Morel-Lavallée lesions without underlying fracture are likely to be missed, which result in chronicity. Management of this condition often requires extensive surgical procedures such as debridement, sclerotherapy, serial percutaneous drainage, negative pressure wound therapy (NPWT), and skin grafting...
November 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27861131/management-of-open-lower-extremity-wounds-with-concomitant-fracture-using-a-porcine-urinary-bladder-matrix
#18
Bruce A Kraemer, Scott E Geiger, Oliver A Deigni, John Tracy Watson
BACKGROUND: Open wounds of the distal third of the leg and foot with exposed bone, fractures, and hardware are challenging wounds for which to achieve stable coverage. The orthopedic advances in lower extremity fracture management over the last 30 years have allowed a rethinking of the standard operative approach to close these complex wounds. MATERIALS AND METHODS: The ability of extracellular matrix (ECM) products to facilitate constructive remodeling of a wound seemed a reasonable approach for treatment, especially in patients who are often poor surgical candidates for more advanced reconstructive procedures...
November 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27589361/the-effect-of-a-bacteria-and-fungi-binding-mesh-dressing-on-the-bacterial-load-of-pressure-ulcers-treated-with-negative-pressure-wound-therapy-a-pilot-study
#19
Marino Ciliberti, Francesco De Lara, Gianfranco Serra, Felice Tafuro, Francesco Maria Iazzetta, Alessia Filosa, Rosa Scognamiglio, Giorgia Ciliberti, Maria Rosaria Veneri
OBJECTIVE: This study was designed to clinically evaluate the efficacy of a bacteria- and-fungi-binding mesh (BFBM) dressing to modify the bacterial load of pressure ulcers (PUs) of categories 3 and 4, when used as a wound contact layer (WCL) during negative pressure wound therapy (NPWT). METHODS: This was an observational single-centre study in patients with PUs of categories 3 or 4, who were treated with NPWT. Patients were observed for 7 days and received NPWT at -80 mm Hg with the BFBM dressing as the WCL...
November 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27589359/the-reliability-of-a-novel-mobile-3-dimensional-wound-measurement-device
#20
Ersilia L Anghel, Anagha Kumar, Thomas E Bigham, Kathryn M Maselli, John S Steinberg, Karen K Evans, Paul J Kim, Christopher E Attinger
BACKGROUND: Objective assessment of wound dimensions is essential for tracking progression and determining treatment effectiveness. A reliability study was designed to establish intrarater and interrater reliability of a novel mobile 3-dimensional wound measurement (3DWM) device. METHODS: Forty-five wounds were assessed by 2 raters using a 3DWM device to obtain length, width, area, depth, and volume measurements. Wounds were also measured manually, using a disposable ruler and digital planimetry...
November 2016: Wounds: a Compendium of Clinical Research and Practice
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