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Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis

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https://www.readbyqxmd.com/read/25379012/mutagenesis-in-the-laci-gene-target-of-e-coli-improved-analysis-for-laci-d-and-laco-mutants
#1
Sarah J Swerdlow, Roel M Schaaper
The lacI gene of E. coli has been a highly useful target for studies of mutagenesis, particularly for analysis of the specificity (spectrum) of mutations generated under a variety of conditions and in various genetic backgrounds. The gene encodes the repressor of the lac operon, and lacI-defective mutants displaying constitutive expression of the operon are readily selected. DNA sequencing of the lacI mutants has often been confined to the N-terminal region of the protein, as it presents a conveniently short target with a high density of detectably mutable sites...
December 1, 2014: Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis
https://www.readbyqxmd.com/read/25147477/deletion-of-brca2-exon-27-causes-defects-in-response-to-both-stalled-and-collapsed-replication-forks
#2
Tae Moon Kim, Mi Young Son, Sherry Dodds, Lingchuan Hu, Paul Hasty
BRCA2 is a tumor suppressor that maintains genomic integrity through double strand break (DSB) repair and replication fork protection. The BRC motifs and an exon 27-encoded domain (Ex27) of BRCA2 interact with the recombinase RAD51 to respectively facilitate the formation and stability of a RAD51 filament on single strand DNA. The BRC-RAD51 associations enable DSB repair while the Ex27-RAD51 association protects the nascent replication strand from MRE11-mediated degradation. MRE11 is a nuclease that facilitates the generation of 3' overhangs needed for homologous recombination (HR)-mediated DSB repair...
August 2014: Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis
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