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Mutation Research. Genetic Toxicology and Environmental Mutagenesis

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https://www.readbyqxmd.com/read/28464995/in-vivo-reporter-gene-mutation-and-micronucleus-assays-in-gpt-delta-mice-treated-with-a-flame-retardant-decabromodiphenyl-ether
#1
Shinji Takasu, Yuji Ishii, Yuh Yokoo, Takuma Tsuchiya, Aki Kijima, Yukio Kodama, Kumiko Ogawa, Takashi Umemura
Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants, have been widely used as additive flame retardants. Recently, the use of brominated flame retardants has been restricted or prohibited under various legislative acts because of the persistence, bioaccumulation potential, and toxicity of these compounds. However, there are also additional concerns regarding environmental contamination and human exposure to PBDEs resulting from informal recycling technology. Decabromodiphenyl ether (decaBDE), one type of PBDE, has carcinogenic potential in the livers of rodents...
April 2017: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/28464994/genotoxic-effects-of-zinc-oxide-nanoparticles-in-nasal-mucosa-cells-are-antagonized-by-titanium-dioxide-nanoparticles
#2
Stephan Hackenberg, Agmal Scherzed, Angela Zapp, Katrin Radeloff, Christian Ginzkey, Thomas Gehrke, Pascal Ickrath, Norbert Kleinsasser
Titanium dioxide nanoparticles (TiO2-NPs) and zinc oxide nanoparticles (ZnO-NPs) are often used in sunscreens and other consumer products due to their photoprotective properties. However, concern exists regarding them possibly causing cyto- and genotoxic effects. The aim of this study was to assess cyto- and genotoxicity of these nanomaterials after single or combined exposure. For this purpose, a battery of cell culture test systems for human nasal mucosa (monolayer, air-liquid interface and mini organ culture) were exposed to 0...
April 2017: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/28464993/genotoxicity-of-two-new-carbazole-derivatives-with-antifungal-activity
#3
Aliy K Zhanataev, Natalya V Eremina, Zlata V Chayka, Vasily I Kazey, Ekaterina L Andrianova, Andrei A Purmal, Elena B Rydkina, Andrey D Durnev
The class of carbazoles includes compounds with high biological activities and broad spectra of action. PLX01107 and PLX01008 are xenomycins, a new subclass of antimicrobial carbazole derivatives demonstrating strong antifungal activity in vitro. We performed three tests, a bacterial reverse mutation assay (Ames test), in vitro cytokinesis-block micronucleus assay, and chromosome aberration test in mouse bone marrow cells, to investigate the possible genotoxicity of these compounds. Despite their structural similarity, the two compounds had different genotoxicity profiles...
April 2017: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/28464992/2-nitroanisole-induced-oxidative-dna-damage-in-salmonella-typhimurium-and-in-rat-urinary-bladder-cells
#4
Kunio Wada, Yoshitaka Katoh, Aya Ohnuma-Koyama, Naofumi Takahashi, Masami Yamada, Kyomu Matsumoto
2-Nitroanisole (2-NA) is used in the manufacturing of azo dyes and causes cancer, mainly in the urinary bladder. Previous in vivo genotoxic data seems to be insufficient to explain the mechanism through which 2-NA induces carcinogenesis, and several bladder carcinogens were reported to induce oxidative DNA damage. Thus, we examined the potential induction of oxidative DNA damage by 2-NA using bacterial strain YG3008, a mutMST-deficient derivative of strain TA100. Consequently, strain YG3008, when compared with strain TA100, was found to be more sensitive to 2-NA, indicating oxidative DNA damage in bacterial cells...
April 2017: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/28464991/induction-of-cytotoxic-and-genotoxic-damage-following-exposure-of-v79-cells-to-cadmium-chloride
#5
Jillian Gobrecht, Claire McDyre, James Comotto, Mindy Reynolds
Cadmium is a toxic heavy metal with many industrial and commercial uses resulting in widespread environmental pollution. Exposure to cadmium occurs occupationally, through tainted food, tobacco leaves, and the environment. Cadmium exposure has been linked to neurological and respiratory problems and cancer. Past studies have examined cytotoxicity, DNA damage, micronuclei formation, or mutagenesis individually, but no study has examined these endpoints together and correlated them with intracellular cadmium concentrations...
April 2017: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/28464990/ephx1-y113h-polymorphism-is-associated-with-increased-risk-of-chronic-obstructive-pulmonary-disease-in-kazakhstan-population
#6
Almira Akparova, Balkiya Abdrakhmanova, Nilanjana Banerjee, Rakhmetkazhy Bersimbaev
Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long term poor airflow which worsens over time. It is considered to be one of the top five chronic diseases of the world in terms of morbidity and mortality. Genetic variability has been found to contribute to the development of COPD. Although association between gene polymorphisms in EPHX1 and TNF-a genes and chronic obstructive pulmonary disease (COPD) have been found but till date no genetic association studies have been done in the COPD affected Kazakhstan population...
April 2017: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637485/peripheral-blood-lymphocyte-micronucleus-frequencies-in-men-from-areas-of-kerala-india-with-high-vs-normal-levels-of-natural-background-ionizing-radiation
#7
LETTER
S M J Mortazavi, G Mortazavi, M Paknahad
No abstract text is available yet for this article.
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637484/polymorphisms-in-metabolism-and-repair-genes-affects-dna-damage-caused-by-open-cast-coal-mining-exposure
#8
Lyda Espitia-Pérez, Milton Quintana Sosa, Shirley Salcedo-Arteaga, Grethel León-Mejía, Luz Stella Hoyos-Giraldo, Hugo Brango, Katia Kvitko, Juliana da Silva, João A P Henriques
Increasing evidence suggest that occupational exposure to open-cast coal mining residues like dust particles, heavy metals and Polycyclic Aromatic Hydrocarbons (PAHs) may cause a wide range of DNA damage and genomic instability that could be associated to initial steps in cancer development and other work-related diseases. The aim of our study was to evaluate if key polymorphisms in metabolism genes CYP1A1Msp1, GSTM1Null, GSTT1Null and DNA repair genes XRCC1Arg194Trp and hOGG1Ser326Cys could modify individual susceptibility to adverse coal exposure effects, considering the DNA damage (Comet assay) and micronucleus formation in lymphocytes (CBMN) and buccal mucosa cells (BMNCyt) as endpoints for genotoxicity...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637483/role-of-exposure-recovery-schedule-in-micronuclei-induction-by-several-promutagens-in-v79-derived-cells-expressing-human-cyp2e1-and-sult1a1
#9
Hansi Jia, Chiteng Zhang, Hansruedi Glatt, Yungang Liu
The standard procedure for the micronucleus test in cell lines requires a short exposure (≤0.5 cell cycle) to the test compounds followed by a long recovery (≥1.5 cell cycle), and in case of negative or equivocal results, a second test with extended exposure (≥2 cell cycles) without or with a recovery time. In general the two procedures are advantageous for detecting clastogens and aneugens, respectively. However, whether the recommended procedures apply to micronucleus tests with promutagens in cell lines genetically engineered for expressing biotransformation enzymes has not been identified...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637482/monitoring-genotoxicity-in-patients-receiving-chemotherapy-for-cancer-application-of-the-pig-a-assay
#10
Katsuyoshi Horibata, Akiko Ukai, Shigeo Ishikawa, Ayako Sugano, Masamitsu Honma
The recently introduced Pig-a in vivo gene mutation assay measures endogeneous mutations of Pig-a (human, PIG-A), an X-linked gene that is conserved across species from rodents to humans. Flow cytometric analysis enables the enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient erythrocytes, resulting from a mutation in Pig-a/PIG-A, in only a few microliters of peripheral blood. Pig-a/PIG-A mutations appear to function in a neutral manner, allowing evaluation of the accumulated genotoxic effects of repeated exposures...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637481/a-comparison-of-the-genotoxicity-of-benzo-a-pyrene-in-four-cell-lines-with-differing-metabolic-capacity
#11
COMPARATIVE STUDY
Ume-Kulsoom Shah, Anna L Seager, Paul Fowler, Shareen H Doak, George E Johnson, Sharon J Scott, Andrew D Scott, Gareth J S Jenkins
Benzo[a]pyrene (B[a]P) is a known genotoxin and carcinogen, yet its genotoxic response at low level exposure has not been determined. This study was conducted to examine the interplay of dose and metabolic capacity on genotoxicity of B[a]P. Investigating and better understanding the biological significance of low level chemical exposures will help improve human health risk assessments. The genotoxic and mutagenic effects of B[a]P were investigated using human cell lines (AHH-1, MCL-5, TK6 and HepG2) with differential expression of the CYP450 enzymes CYP1A1, 1B1 and1A2 involved in B[a]P metabolism...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637480/levels-of-dna-damage-in-peripheral-blood-lymphocytes-of-patients-undergoing-standard-hemodialysis-vs-on-line-hemodiafiltration-a-comet-assay-investigation
#12
COMPARATIVE STUDY
Zuray Corredor, Lara Rodríguez-Ribera, Irene Silva, Juan Manuel Díaz, José Ballarín, Ricard Marcos, Elisabet Coll, Susana Pastor
Chronic kidney disease (CKD) patients exhibit high levels of genetic damage. Part of this genetic damage is supposed to be caused by the hemodialysis (HD) therapy. Different and more efficient HD procedures could reduce the genetic damage and improve health status of CKD patients. In the present study, we analyzed if changing to online hemodiafiltration (OL-HDF) has a beneficial effect on the levels of genetic damage. The levels of genetic damage (DNA breaks and oxidatively damaged DNA) were analyzed in peripheral blood lymphocytes by using the comet assay...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542714/dose-response-of-multiple-parameters-for-calyculin-a-induced-premature-chromosome-condensation-in-human-peripheral-blood-lymphocytes-exposed-to-high-doses-of-cobalt-60-gamma-rays
#13
Xue Lu, Hua Zhao, Jiang-Bin Feng, Xiao-Tao Zhao, De-Qing Chen, Qing-Jie Liu
Many studies have investigated exposure biomarkers for high dose radiation. However, no systematic study on which biomarkers can be used in dose estimation through premature chromosome condensation (PCC) analysis has been conducted. The present study aims to screen the high-dose radiation exposure indicator in calyculin A-induced PCC. The dose response of multiple biological endpoints, including G2/A-PCC (G2/M and M/A-PCC) index, PCC ring (PCC-R), ratio of the longest/shortest length (L/L ratio), and length and width ratio of the longest chromosome (L/B ratio), were investigated in calyculin A-induced G2/A-PCC spreads in human peripheral blood lymphocytes exposed to 0-20Gy (dose-rate of 1Gy/min) cobalt-60 gamma-rays...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542713/dihydroxyselenolane-dhs-supplementation-improves-survival-following-whole-body-irradiation-wbi-by-suppressing-tissue-specific-inflammatory-responses
#14
Amit Kunwar, Prachi Verma, H N Bhilwade, Michio Iwaoka, K Indira Priyadarsini
Dihydroxyselenolane (DHS), a simple water-soluble organoselenium compound, was evaluated for radioprotection in BALB/c mice after whole-body irradiation (WBI) (8Gy (60)Co, 1Gy/min), by monitoring 30-d post-irradiation survival and biochemical/histological changes in radiosensitive organs. Intraperitoneal administration of DHS at 2mg/kg for five consecutive days before irradiation and three times per week during the post-irradiation period showed maximum benefit (40% improvement in 30 d post-irradiation survival)...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542712/effects-of-zno-nanoparticles-in-plants-cytotoxicity-genotoxicity-deregulation-of-antioxidant-defenses-and-cell-cycle-arrest
#15
Manosij Ghosh, Aditi Jana, Sonali Sinha, Manivannan Jothiramajayam, Anish Nag, Anirban Chakraborty, Amitava Mukherjee, Anita Mukherjee
Cytotoxicity, genotoxicity, and biochemical effects were evaluated in the plants Allium cepa, Nicotiana tabacum, and Vicia faba following exposure to ZnO nanoparticles (np; diameter, ∼85nm). In the root meristems of Allium cepa cells, we observed loss of membrane integrity, increased chromosome aberrations, micronucleus formation, DNA strand breaks, and cell-cycle arrest at the G2/M checkpoint. In Vicia faba and Nicotiana tabacum, we observed increased intracellular ROS production, lipid peroxidation, and activities of some antioxidant enzymes...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542711/uvb-irradiation-enhanced-zinc-oxide-nanoparticles-induced-dna-damage-and-cell-death-in-mouse-skin
#16
Anu Pal, Shamshad Alam, Sandeep Mittal, Nidhi Arjaria, Jai Shankar, Mahadeo Kumar, Dhirendra Singh, Alok Kumar Pandey, Kausar Mahmood Ansari
UV-induced reactive oxygen species (ROS) have been implicated in photocarcinogenesis and skin aging. This is because UV-induced ROS can induce DNA damage that, if unrepaired, can lead to carcinogenesis. Sunscreens contain UV attenuators, such as organic chemical and/or physical UV filters, which can prevent all forms of damage from UV irradiation. In recent years, the effective broad-spectrum UV attenuation properties of ZnO-nanoparticles (ZnO-NPs) have made them attractive as active components in sunscreens and other personal care products...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542710/genotoxicity-and-cytotoxicity-assessment-of-new-ethyl-carbamates-with-ixodicidal-activity
#17
María Guadalupe Prado-Ochoa, Marco Antonio Muñoz-Guzmán, Víctor Hugo Vázquez-Valadez, Ana María Velázquez-Sánchez, Ana María Salazar, Patricia Ramírez-Noguera, Enrique Angeles, Fernando Alba-Hurtado
The mammalian erythrocyte micronucleus test was used on the peripheral blood of Wistar rats exposed to two new ethyl-carbamates: ethyl-4-bromophenyl-carbamate (LQM 919) and ethyl-4-chlorophenyl-carbamate (LQM 996) to analyze their genotoxic potential. The mitotic index and cell proliferation kinetics in human lymphocyte cultures in the presence of these ethyl-carbamates were used to evaluate cytotoxicity and cytostaticity respectively. Exposure to greater acute doses (300mg/kg) and to all of the subchronic doses (12...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542709/toxic-effect-and-genotoxicity-of-the-semisynthetic-derivatives-dillapiole-ethyl-ether-and-dillapiole-n-butyl-ether-for-control-of-aedes-albopictus-diptera-culicidae
#18
Sabrina da Fonseca Meireles, Pedro Rauel Cândido Domingos, Ana Cristina da Silva Pinto, Míriam Silva Rafael
Two derivatives of dillapiole, dillapiole ethyl ether (1KL39-B) and butyl ether-n dillapiole (1KL43-C), were studied for their toxicity and genotoxicity against Aedes albopictus, to help develop new strategies for the control of this potential vector of dengue and other arboviruses, because it is resistant to synthetic insecticides. Eggs and larvae exposed to different concentrations of 1KL39-B (25, 30, 50, 70, and 80μg/mL) and of 1KL43-C (12.5, 20, 25, 30 and 40μg/mL) exhibited toxicity and susceptibility, with 100% mortality...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27476335/long-term-genotoxic-effects-of-immunosuppressive-drugs-on-lymphocytes-of-kidney-transplant-recipients
#19
Heloísa Lizotti Cilião, Rossana Batista de Oliveira Camargo-Godoy, Gustavo Rafael Mazzaron Barcelos, Amanda Zanuto, Vinicius Daher Alvares Delfino, Ilce Mara de Syllos Cólus
Immunosuppressive therapy can prevent rejection after organ transplantation. However, increased cancer risk is a serious complication among patients undergoing such therapy. We have evaluated whether prolonged use of immunosuppressive drugs is genotoxic. DNA instability was assessed, using the comet and micronucleus assays, in blood lymphocytes of 76 kidney transplant patients. DNA damage detected by the comet assay increased with time after transplantation. The estimated glomerular filtration rate of the patients did not influence the incidence of DNA damage...
August 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27476334/resveratrol-affects-dna-damage-induced-by-ionizing-radiation-in-human-lymphocytes-in-vitro
#20
Emiliano Basso, Giulia Regazzo, Mario Fiore, Valentina Palma, Gianandrea Traversi, Antonella Testa, Francesca Degrassi, Renata Cozzi
Resveratrol (3,4',5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histone deacetylase activity...
August 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
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