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Mutation Research. Genetic Toxicology and Environmental Mutagenesis

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https://www.readbyqxmd.com/read/27637485/peripheral-blood-lymphocyte-micronucleus-frequencies-in-men-from-areas-of-kerala-india-with-high-vs-normal-levels-of-natural-background-ionizing-radiation
#1
LETTER
S M J Mortazavi, G Mortazavi, M Paknahad
No abstract text is available yet for this article.
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637484/polymorphisms-in-metabolism-and-repair-genes-affects-dna-damage-caused-by-open-cast-coal-mining-exposure
#2
Lyda Espitia-Pérez, Milton Quintana Sosa, Shirley Salcedo-Arteaga, Grethel León-Mejía, Luz Stella Hoyos-Giraldo, Hugo Brango, Katia Kvitko, Juliana da Silva, João A P Henriques
Increasing evidence suggest that occupational exposure to open-cast coal mining residues like dust particles, heavy metals and Polycyclic Aromatic Hydrocarbons (PAHs) may cause a wide range of DNA damage and genomic instability that could be associated to initial steps in cancer development and other work-related diseases. The aim of our study was to evaluate if key polymorphisms in metabolism genes CYP1A1Msp1, GSTM1Null, GSTT1Null and DNA repair genes XRCC1Arg194Trp and hOGG1Ser326Cys could modify individual susceptibility to adverse coal exposure effects, considering the DNA damage (Comet assay) and micronucleus formation in lymphocytes (CBMN) and buccal mucosa cells (BMNCyt) as endpoints for genotoxicity...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637483/role-of-exposure-recovery-schedule-in-micronuclei-induction-by-several-promutagens-in-v79-derived-cells-expressing-human-cyp2e1-and-sult1a1
#3
Hansi Jia, Chiteng Zhang, Hansruedi Glatt, Yungang Liu
The standard procedure for the micronucleus test in cell lines requires a short exposure (≤0.5 cell cycle) to the test compounds followed by a long recovery (≥1.5 cell cycle), and in case of negative or equivocal results, a second test with extended exposure (≥2 cell cycles) without or with a recovery time. In general the two procedures are advantageous for detecting clastogens and aneugens, respectively. However, whether the recommended procedures apply to micronucleus tests with promutagens in cell lines genetically engineered for expressing biotransformation enzymes has not been identified...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637482/monitoring-genotoxicity-in-patients-receiving-chemotherapy-for-cancer-application-of-the-pig-a-assay
#4
Katsuyoshi Horibata, Akiko Ukai, Shigeo Ishikawa, Ayako Sugano, Masamitsu Honma
The recently introduced Pig-a in vivo gene mutation assay measures endogeneous mutations of Pig-a (human, PIG-A), an X-linked gene that is conserved across species from rodents to humans. Flow cytometric analysis enables the enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient erythrocytes, resulting from a mutation in Pig-a/PIG-A, in only a few microliters of peripheral blood. Pig-a/PIG-A mutations appear to function in a neutral manner, allowing evaluation of the accumulated genotoxic effects of repeated exposures...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637481/a-comparison-of-the-genotoxicity-of-benzo-a-pyrene-in-four-cell-lines-with-differing-metabolic-capacity
#5
Ume-Kulsoom Shah, Anna L Seager, Paul Fowler, Shareen H Doak, George E Johnson, Sharon J Scott, Andrew D Scott, Gareth J S Jenkins
Benzo[a]pyrene (B[a]P) is a known genotoxin and carcinogen, yet its genotoxic response at low level exposure has not been determined. This study was conducted to examine the interplay of dose and metabolic capacity on genotoxicity of B[a]P. Investigating and better understanding the biological significance of low level chemical exposures will help improve human health risk assessments. The genotoxic and mutagenic effects of B[a]P were investigated using human cell lines (AHH-1, MCL-5, TK6 and HepG2) with differential expression of the CYP450 enzymes CYP1A1, 1B1 and1A2 involved in B[a]P metabolism...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27637480/levels-of-dna-damage-in-peripheral-blood-lymphocytes-of-patients-undergoing-standard-hemodialysis-vs-on-line-hemodiafiltration-a-comet-assay-investigation
#6
Zuray Corredor, Lara Rodríguez-Ribera, Irene Silva, Juan Manuel Díaz, José Ballarín, Ricard Marcos, Elisabet Coll, Susana Pastor
Chronic kidney disease (CKD) patients exhibit high levels of genetic damage. Part of this genetic damage is supposed to be caused by the hemodialysis (HD) therapy. Different and more efficient HD procedures could reduce the genetic damage and improve health status of CKD patients. In the present study, we analyzed if changing to online hemodiafiltration (OL-HDF) has a beneficial effect on the levels of genetic damage. The levels of genetic damage (DNA breaks and oxidatively damaged DNA) were analyzed in peripheral blood lymphocytes by using the comet assay...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542714/dose-response-of-multiple-parameters-for-calyculin-a-induced-premature-chromosome-condensation-in-human-peripheral-blood-lymphocytes-exposed-to-high-doses-of-cobalt-60-gamma-rays
#7
Xue Lu, Hua Zhao, Jiang-Bin Feng, Xiao-Tao Zhao, De-Qing Chen, Qing-Jie Liu
Many studies have investigated exposure biomarkers for high dose radiation. However, no systematic study on which biomarkers can be used in dose estimation through premature chromosome condensation (PCC) analysis has been conducted. The present study aims to screen the high-dose radiation exposure indicator in calyculin A-induced PCC. The dose response of multiple biological endpoints, including G2/A-PCC (G2/M and M/A-PCC) index, PCC ring (PCC-R), ratio of the longest/shortest length (L/L ratio), and length and width ratio of the longest chromosome (L/B ratio), were investigated in calyculin A-induced G2/A-PCC spreads in human peripheral blood lymphocytes exposed to 0-20Gy (dose-rate of 1Gy/min) cobalt-60 gamma-rays...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542713/dihydroxyselenolane-dhs-supplementation-improves-survival-following-whole-body-irradiation-wbi-by-suppressing-tissue-specific-inflammatory-responses
#8
Amit Kunwar, Prachi Verma, H N Bhilwade, Michio Iwaoka, K Indira Priyadarsini
Dihydroxyselenolane (DHS), a simple water-soluble organoselenium compound, was evaluated for radioprotection in BALB/c mice after whole-body irradiation (WBI) (8Gy (60)Co, 1Gy/min), by monitoring 30-d post-irradiation survival and biochemical/histological changes in radiosensitive organs. Intraperitoneal administration of DHS at 2mg/kg for five consecutive days before irradiation and three times per week during the post-irradiation period showed maximum benefit (40% improvement in 30 d post-irradiation survival)...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542712/effects-of-zno-nanoparticles-in-plants-cytotoxicity-genotoxicity-deregulation-of-antioxidant-defenses-and-cell-cycle-arrest
#9
Manosij Ghosh, Aditi Jana, Sonali Sinha, Manivannan Jothiramajayam, Anish Nag, Anirban Chakraborty, Amitava Mukherjee, Anita Mukherjee
Cytotoxicity, genotoxicity, and biochemical effects were evaluated in the plants Allium cepa, Nicotiana tabacum, and Vicia faba following exposure to ZnO nanoparticles (np; diameter, ∼85nm). In the root meristems of Allium cepa cells, we observed loss of membrane integrity, increased chromosome aberrations, micronucleus formation, DNA strand breaks, and cell-cycle arrest at the G2/M checkpoint. In Vicia faba and Nicotiana tabacum, we observed increased intracellular ROS production, lipid peroxidation, and activities of some antioxidant enzymes...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542711/uvb-irradiation-enhanced-zinc-oxide-nanoparticles-induced-dna-damage-and-cell-death-in-mouse-skin
#10
Anu Pal, Shamshad Alam, Sandeep Mittal, Nidhi Arjaria, Jai Shankar, Mahadeo Kumar, Dhirendra Singh, Alok Kumar Pandey, Kausar Mahmood Ansari
UV-induced reactive oxygen species (ROS) have been implicated in photocarcinogenesis and skin aging. This is because UV-induced ROS can induce DNA damage that, if unrepaired, can lead to carcinogenesis. Sunscreens contain UV attenuators, such as organic chemical and/or physical UV filters, which can prevent all forms of damage from UV irradiation. In recent years, the effective broad-spectrum UV attenuation properties of ZnO-nanoparticles (ZnO-NPs) have made them attractive as active components in sunscreens and other personal care products...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542710/genotoxicity-and-cytotoxicity-assessment-of-new-ethyl-carbamates-with-ixodicidal-activity
#11
María Guadalupe Prado-Ochoa, Marco Antonio Muñoz-Guzmán, Víctor Hugo Vázquez-Valadez, Ana María Velázquez-Sánchez, Ana María Salazar, Patricia Ramírez-Noguera, Enrique Angeles, Fernando Alba-Hurtado
The mammalian erythrocyte micronucleus test was used on the peripheral blood of Wistar rats exposed to two new ethyl-carbamates: ethyl-4-bromophenyl-carbamate (LQM 919) and ethyl-4-chlorophenyl-carbamate (LQM 996) to analyze their genotoxic potential. The mitotic index and cell proliferation kinetics in human lymphocyte cultures in the presence of these ethyl-carbamates were used to evaluate cytotoxicity and cytostaticity respectively. Exposure to greater acute doses (300mg/kg) and to all of the subchronic doses (12...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27542709/toxic-effect-and-genotoxicity-of-the-semisynthetic-derivatives-dillapiole-ethyl-ether-and-dillapiole-n-butyl-ether-for-control-of-aedes-albopictus-diptera-culicidae
#12
Sabrina da Fonseca Meireles, Pedro Rauel Cândido Domingos, Ana Cristina da Silva Pinto, Míriam Silva Rafael
Two derivatives of dillapiole, dillapiole ethyl ether (1KL39-B) and butyl ether-n dillapiole (1KL43-C), were studied for their toxicity and genotoxicity against Aedes albopictus, to help develop new strategies for the control of this potential vector of dengue and other arboviruses, because it is resistant to synthetic insecticides. Eggs and larvae exposed to different concentrations of 1KL39-B (25, 30, 50, 70, and 80μg/mL) and of 1KL43-C (12.5, 20, 25, 30 and 40μg/mL) exhibited toxicity and susceptibility, with 100% mortality...
September 1, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27476335/long-term-genotoxic-effects-of-immunosuppressive-drugs-on-lymphocytes-of-kidney-transplant-recipients
#13
Heloísa Lizotti Cilião, Rossana Batista de Oliveira Camargo-Godoy, Gustavo Rafael Mazzaron Barcelos, Amanda Zanuto, Vinicius Daher Alvares Delfino, Ilce Mara de Syllos Cólus
Immunosuppressive therapy can prevent rejection after organ transplantation. However, increased cancer risk is a serious complication among patients undergoing such therapy. We have evaluated whether prolonged use of immunosuppressive drugs is genotoxic. DNA instability was assessed, using the comet and micronucleus assays, in blood lymphocytes of 76 kidney transplant patients. DNA damage detected by the comet assay increased with time after transplantation. The estimated glomerular filtration rate of the patients did not influence the incidence of DNA damage...
August 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27476334/resveratrol-affects-dna-damage-induced-by-ionizing-radiation-in-human-lymphocytes-in-vitro
#14
Emiliano Basso, Giulia Regazzo, Mario Fiore, Valentina Palma, Gianandrea Traversi, Antonella Testa, Francesca Degrassi, Renata Cozzi
Resveratrol (3,4',5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histone deacetylase activity...
August 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27476333/the-antileishmanial-drug-miltefosine-impavido-%C3%A2-causes-oxidation-of-dna-bases-apoptosis-and-necrosis-in-mammalian-cells
#15
Patrícia Valéria Castelo Branco, Rossy-Eric Pereira Soares, Luís Cláudio Lima de Jesus, Vanessa Ribeiro Moreira, Hugo José Alves, Marta Regina de Castro Belfort, Vera Lucia Maciel Silva, Silma Regina Ferreira Pereira
Miltefosine was developed to treat skin cancer; further studies showed that the drug also has activity against Leishmania. Miltefosine is the first oral agent for treating leishmaniasis. However, its mechanism of action is not completely understood. We have evaluated the induction of DNA damage by miltefosine. Cytotoxicity and genotoxicity (comet assay) tests were performed on human leukocytes exposed to the drug in vitro. Apoptosis and necrosis were also evaluated. In vivo tests were conducted in Swiss male mice (Mus musculus) treated orally with miltefosine...
August 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27476332/cytochrome-p450-expression-system-for-high-throughput-real-time-detection-of-genotoxicity-application-to-the-study-of-human-cyp1a2-variants
#16
Bernardo Brito Palma, Daniela Moutinho, Philippe Urban, José Rueff, Michel Kranendonk
Individual variations in cytochrome P450-mediated metabolism are believed to contribute to individual susceptibility to chemical carcinogenesis. CYP1A2 is one of the major forms of cytochrome P450 involved in drug metabolism and bioactivation of carcinogens. We have applied a recently developed high-throughput Salmonella typhimurium TA1535 system for detection of DNA damaging agents to the study of CYP1A2 polymorphisms. Non-synonymous variants T83M [CYP1A2*9], S212C [CYP1A2*12], S298R [part of CYP1A2*21], G299S [CYP1A2*13], I314V [no allele designation], I386F [CYP1A2*4], C406Y [CYP1A2*5] and R456H [CYP1A2*8] were examined...
August 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27476331/polyvinyl-polypyrrolidone-attenuates-genotoxicity-of-silver-nanoparticles-synthesized-via-green-route-tested-in-lathyrus-sativus-l-root-bioassay
#17
Kamal K Panda, V Mohan M Achary, Ganngam Phaomie, Hrushi K Sahu, Narasimham L Parinandi, Brahma B Panda
The silver nanoparticles (AgNPs) were synthesized extracellularly from silver nitrate (AgNO3) using kernel extract from ripe mango Mengifera indica L. under four different reaction conditions of the synthesis media such as the (i) absence of the reducing agent, trisodium citrate (AgNPI), (ii) presence of the reducing agent (AgNPII), (iii) presence of the cleansing agent, polyvinyl polypyrrolidone, PVPP (AgNPIII), and (iv) presence of the capping agent, polyvinyl pyrrolidone, PVP (AgNPIV). The synthesis of the AgNPs was monitored by UV-vis spectrophotometry...
August 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27476330/cytotoxic-mutagenicity-and-genotoxicity-effects-of-guanylhydrazone-derivatives
#18
Valéria Rodrigues Pinhatti, Juliana da Silva, Tales Leandro Costa Martins, Dinara Jaqueline Moura, Renato Moreira Rosa, Izabel Villela, Cheila Denise Ottonelli Stopiglia, Selma da Silva Santos, Maria Lúcia Scroferneker, Carlos Renato Machado, Jenifer Saffi, João Antonio Pêgas Henriques
Several studies have reported that guanylhydrazones display a variety of desirable biological properties, such as antihypertensive, antibacterial, and antimalarial behaviour. They furthermore promote anti-pneumocystosis and anti-trypanosomiasis, exhibit antitumor activity, and show significant cytotoxicity against cancer cell lines. In this work, we have evaluated the cytotoxicity, mutagenicity, and genotoxicity of two guanylhydrazones derivatives, (E)-2-[(2,3-dimethoxyphenyl) methylene] hydrazine carboxymidamide hydrochloride (2,3-DMeB) and (E)-2-[(3,4-dimethoxyphenyl) methylene] hydrazine carboxymidamide hydrochloride (3,4-DMeB), in different biological models...
August 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27402482/toxic-and-dna-damaging-effects-of-a-functionalized-fullerene-in-human-embryonic-lung-fibroblasts
#19
E S Ershova, V A Sergeeva, A I Chausheva, D G Zheglo, V A Nikitina, T D Smirnova, L V Kameneva, L N Porokhovnik, S I Kutsev, P A Troshin, I I Voronov, E A Khakina, N N Veiko, S V Kostyuk
Water-soluble fullerenes have been studied as potential nanovectors and therapeutic agents, but their possible toxicity is of concern. We have studied the effects of F-828, a soluble fullerene [C60] derivative, on diploid human embryonic lung fibroblasts (HELFs) in vitro. F-828 causes complex time-dependent changes in ROS levels. Inhibition of Nox4 activity by plumbagin blocks F-828-dependent ROS elevation. F-828 induces DNA breaks, as measured by the comet assay and γH2AX expression, and the activities of the transcription factors NF-kB and p53 increase...
July 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27402481/quantification-of-the-mutagenic-potency-and-repair-of-glycidol-induced-dna-lesions
#20
Jenny Aasa, Daniel Vare, Hitesh V Motwani, Dag Jenssen, Margareta Törnqvist
Glycidol (Gly) is an electrophilic low-molecular weight epoxide that is classified by IARC as probably carcinogenic to humans. Humans might be exposed to Gly from food, e.g. refined vegetable oils, where Gly has been found as a food process contaminant. It is therefore important to investigate and quantify the genotoxicity of Gly as a primary step towards cancer risk assessment of the human exposure. Here, quantification of the mutagenic potency expressed per dose (AUC: area under the concentration-time curve) of Gly has been performed in Chinese hamster ovary (CHO) cells, using the HPRT assay...
July 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
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