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Journal of Food and Drug Analysis

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https://www.readbyqxmd.com/read/29703391/effects-of-processing-adjuvants-on-traditional-chinese-herbs
#1
REVIEW
Lin-Lin Chen, Robert Verpoorte, Hung-Rong Yen, Wen-Huang Peng, Yung-Chi Cheng, Jung Chao, Li-Heng Pao
Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude drugs. Proper processing is essential to ensure the quality and safety of traditional Chinese medicines (TCMs). Therefore, sound knowledge of processing principles is crucial to the standardized use of these processing adjuvants and to facilitate the production and clinical use of decoction pieces...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703390/concurrent-administration-of-anticancer-chemotherapy-drug-and-herbal-medicine-on-the-perspective-of-pharmacokinetics
#2
REVIEW
Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
With an increasing number of cancer patients seeking an improved quality of life, complementary and alternative therapies are becoming more common ways to achieve such improvements. The potential risks of concurrent administration are serious and must be addressed. However, comprehensive evidence for the risks and benefits of combining anticancer drugs with traditional herbs is rare. Pharmacokinetic investigations are an efficient way to understand the influence of concomitant remedies. Therefore, this study aimed to collect the results of pharmacokinetic studies relating to the concurrent use of cancer chemotherapy and complementary and alternative therapies...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703389/association-of-antioxidant-nutraceuticals-and-acetaminophen-paracetamol-friend-or-foe
#3
REVIEW
Mohamed Abdel-Daim, Abdelrahman Ibrahim Abushouk, Raffaella Reggi, Nagendra Sastry Yarla, Maura Palmery, Ilaria Peluso
Acetaminophen (paracetamol or APAP) is an analgesic and antipyretic drug that can induce oxidative stress-mediated hepatotoxicity at high doses. Several studies reported that antioxidant nutraceuticals, in particular phenolic phytochemicals from dietary food, spices, herbs and algae have hepatoprotective effects. Others, however, suggested that they may negatively impact the metabolism, efficacy and toxicity of APAP. The aim of this review is to discuss the pros and cons of the association of antioxidant nutraceuticals and APAP by reviewing the in vivo evidence, with particular reference to APAP pharmacokinetics and hepatotoxicity...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703388/update-of-green-tea-interactions-with-cardiovascular-drugs-and-putative-mechanisms
#4
REVIEW
José Pablo Werba, Shingen Misaka, Monica Gianna Giroli, Kenju Shimomura, Manuela Amato, Niccolò Simonelli, Lorenzo Vigo, Elena Tremoli
Many patients treated with cardiovascular (CV) drugs drink green tea (GT), either as a cultural tradition or persuaded of its putative beneficial effects for health. Yet, GT may affect the pharmacokinetics and pharmacodynamics of CV compounds. Novel GT-CV drug interactions were reported for rosuvastatin, sildenafil and tacrolimus. Putative mechanisms involve inhibitory effects of GT catechins at the intestinal level on influx transporters OATP1A2 or OATP2B1 for rosuvastatin, on CYP3A for sildenafil and on both CYP3A and the efflux transporter p-glycoprotein for tacrolimus...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703387/food-drug-interactions-precipitated-by-fruit-juices-other-than-grapefruit-juice-an-update-review
#5
REVIEW
Meng Chen, Shu-Yi Zhou, Erlinda Fabriaga, Pian-Hong Zhang, Quan Zhou
This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703386/organic-solute-carrier-22-slc22-family-potential-for-interactions-with-food-herbal-dietary-supplements-endogenous-compounds-and-drugs
#6
REVIEW
Raymond E Lai, Christopher E Jay, Douglas H Sweet
Many drugs, hormones, components of herbal medicines, environmental pesticides and toxins are Solute Carrier family 22 (SLC22) substrates. The last twenty years has seen great progress in determining SLC22 tissue expression profiles, membrane localization, energetics, substrate profiles and biopharmaceutical significance. However, much still remains to be answered in terms of SLC22 family member's roles in 'normal' physiology as compared to pathophysiological states, as well as in drug interactions that impact pharmacokinetics, efficacy and toxicity...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703385/transporter-mediated-natural-product-drug-interactions-for-the-treatment-of-cardiovascular-diseases
#7
REVIEW
Weibin Zha
The growing use of natural products in cardiovascular (CV) patients has been greatly raising the concerns about potential natural product-CV drug interactions. Some of these may lead to unexpected cardiovascular adverse effects and it is, therefore, essential to identify or predict potential natural product-CV drug interactions, and to understand the underlying mechanisms. Drug transporters are important determinants for the pharmacokinetics of drugs and alterations of drug transport has been recognized as one of the major causes of natural product-drug interactions...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703384/risk-undermined-in-the-bilateral-pharmaceutical-regulatory-system-in-taiwan
#8
REVIEW
Hui-Po Wang, Chun-Li Wang
The concept of Pharmacovigilance Planning and Risk Minimization Planning (PVP/RMP), initiated by the International Conference on Harmonization (ICH), addressed an important conceptual change from monitoring the safety of individual medicine to proactively conducting risk prevention for the minimization of medication error. However, the implementation of PVP/RMP is a challenge in societies like Taiwan where irrational medication and co-medication is prevalent. It is even more difficult in Taiwan where two regulatory bodies are governing pharmaceutical affairs, namely Taiwan Food and Drug Administration (TFDA) in charge of Western Medicine (WM) and the Department of Chinese Medicine and Pharmacy (DCMP) in charge of Traditional Chinese Medicine (TCM)...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703383/pxr-as-a-mediator-of-herb-drug-interaction
#9
REVIEW
Brett C Hogle, Xiudong Guan, M Maggie Folan, Wen Xie
Medicinal herbs have been a part of human medicine for thousands of years. The herb-drug interaction is an extension of drug-drug interaction, in which the consumptions of herbs cause alterations in the metabolism of drugs the patients happen to take at the same time. The pregnane X receptor (PXR) has been established as one of the most important transcriptional factors that regulate the expression of phase I enzymes, phase II enzymes, and drug transporters in the xenobiotic responses. Since its initial discovery, PXR has been implicated in multiple herb-drug interactions that can lead to alterations of the drug's pharmacokinetic properties and cause fluctuating therapeutic efficacies, possibly leading to complications...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703382/transporter-mediated-interaction-of-indican-and-methotrexate-in-rats
#10
Shiuan-Pey Lin, Chung-Ping Yu, Yu-Chi Hou, Ching-Ya Huang, Lu-Ching Ho, Shu-Ling Chan
Indican (indoxyl-β-D-glucoside) is present in several Chinese herbs e.g. Isatis indigotica, Polygonum tinctorium and Polygonum perfoliatum. The major metabolite of indican was indoxyl sulfate (IS), an uremic toxin which was a known substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4. Methotrexate (MTX), an important immunosuppressant with narrow therapeutic window, is a substrate of OAT 1, 2, 3, 4 and MRP 1, 2, 3, 4. We hypothesized that IS, the major metabolite of oral indican, might inhibit the renal excretion of MTX mediated by OAT 1, OAT 3 and MRP 4...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703381/activation-of-p-glycoprotein-and-cyp-3a-by-coptidis-rhizoma-in-vivo-using-cyclosporine-as-a-probe-substrate-in-rats
#11
Chung-Ping Yu, Ching-Ya Huang, Shiuan-Pey Lin, Yu-Chi Hou
Coptidis Rhizoma (CR), the rhizome of Coptis chinensis FRANCH, is a popular Chinese herb. CR contains plenty of isoquinoline alkaloids such as berberine, coptisine and palmatine. Cyclosporine (CSP), an important immunosuppressant with narrow therapeutic window, is employed as a probe substrate of P-glycoprotein (P-gp) and CYP3A4 in order to investigate the in vivo modulation effect of CR on P-gp and CYP3A4. Three groups of rats were orally administered CSP without and with single dose or repeated dosing of CR in a parallel design...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703380/a-regulatory-science-viewpoint-on-botanical-drug-interactions
#12
REVIEW
Manuela Grimstein, Shiew-Mei Huang
There is a continued predisposition of concurrent use of drugs and botanical products. Consumers often self-administer botanical products without informing their health care providers. The perceived safety of botanical products with lack of knowledge of the interaction potential poses a challenge for providers and both efficacy and safety concerns for patients. Botanical-drug combinations can produce untoward effects when botanical constituents modulate drug metabolizing enzymes and/or transporters impacting the systemic or tissue exposure of concomitant drugs...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703379/excipient-drug-pharmacokinetic-interactions-effect-of-disintegrants-on-efflux-across-excised-pig-intestinal-tissues
#13
Werner Gerber, Josias H Hamman, Johan D Steyn
Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions may be caused by modulation of efflux transporter proteins, intercellular tight junctions and/or metabolic enzyme amongst others. In this study, five disintegrants from different chemical classes were evaluated for P-glycoprotein (P-gp) related inhibition and tight junction modulation effects...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29703378/preface
#14
EDITORIAL
Pei-Dawn Lee Chao
No abstract text is available yet for this article.
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29567263/exploration-of-wedelia-chinensis-leaf-assisted-silver-nanoparticles-for-antioxidant-antibacterial-and-in-vitro-cytotoxic-applications
#15
Merina Paul Das, Jeyanthi Rebecca Livingstone, Pandiyarasan Veluswamy, Jayabrata Das
Green synthetic route of silver nanoparticles (AgNPs) has already been proved to be an advantageous over other physico-chemical approaches due to its simplicity, cost effectiveness, ecofriendly and nontoxicity. In this finding, aqueous Wedelia chinensis leaf extract (WLE) mediated synthesis of AgNPs was approached. Surface plasmon resonance (SPR) band at 408 nm preliminary indicated the formation of AgNPs, while TEM and XRD characterization confirmed the formation of spherically shaped and crystalline AgNPs with an average size of 31...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29567262/oxidative-stress-evoked-damages-leading-to-attenuated-memory-and-inhibition-of-nmdar-camkii-erk-creb-signalling-on-consumption-of-aspartame-in-rat-model
#16
Ashok Iyaswamy, Ananth Kumar Kammella, Citarasu Thavasimuthu, Wankhar Wankupar, Wankhar Dapkupar, Sambantham Shanmugam, Ravindran Rajan, Sheeladevi Rathinasamy
Many controversial reports are available on the use of aspartame as it releases methanol as one of its metabolite during metabolism. The present study proposes to investigate whether long term (90 days) aspartame (40 mg/kg b.wt) administration could induce oxidative stress and alter the memory in Wistar strain male albino rats. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included as a model to study the effects of aspartame. Wistar strain albino rats were administered with aspartame (40 mg/kg b...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29567261/triple-component-nanocomposite-films-prepared-using-a-casting-method-its-potential-in-drug-delivery
#17
Sadia Gilani, Sadullah Mir, Momina Masood, Abida Kalsoom Khan, Rehana Rashid, Saira Azhar, Akhtar Rasul, Muhammad Nadeem Ashraf, Muhammad Khurram Waqas, Ghulam Murtaza
The purpose of this study was to fabricate a triple-component nanocomposite system consisting of chitosan, polyethylene glycol (PEG), and drug for assessing the application of chitosan-PEG nanocomposites in drug delivery and also to assess the effect of different molecular weights of PEG on nanocomposite characteristics. The casting/solvent evaporation method was used to prepare chitosan-PEG nanocomposite films incorporating piroxicam-β-cyclodextrin. In order to characterize the morphology and structure of nanocomposites, X-ray diffraction technique, scanning electron microscopy, thermogravimetric analysis, and Fourier transmission infrared spectroscopy were used...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29567260/ultra-sensitive-electrochemical-sensing-of-acetaminophen-and-codeine-in-biological-fluids-using-cuo-cufe-2-o-4-nanoparticles-as-a-novel-electrocatalyst
#18
Foroozan Hasanpour, Masoumeh Taei, Somayeh Tahmasebi
Copper ferrite-copper oxide (CuO-CuFe2 O4 ) nanoparticles as a semiconductor composite with p-n junction were synthesized by co-precipitation reaction. Then, a novel CuO-CuFe2 O4 carbon paste modified electrode was fabricated which displays an effectual electrocatalytic response to the oxidation of acetaminophen (AC) and codeine (CO). A linear range of 0.01-1.5 μmol L-1 and 0.06-10.0 μmol L-1 with the detection limits of 0.007 μmol L-1 and 0.01 μmol L-1 were achieved for AC and CO, respectively...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29567259/in-vitro-and-in-vivo-assessment-of-delivery-of-hydrophobic-molecules-and-plasmid-dnas-with-peo-ppo-peo-polymeric-micelles-on-cornea
#19
Feichin Hsiao, Po-Yang Huang, Takao Aoyagi, Shwu-Fen Chang, Jiahorng Liaw
The stability and bio-distribution of genes or drug complexes with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, Pluronic F-68) polymeric micelles (PM) are essential for an effective nanosized PM delivery system. We used Förster resonance energy transfer (FRET) pairs with PM and measured the FRET ratio to assess the stability of PM in vitro and in vivo on the cornea. The FRET ratio reached a plateau at 0.8 with 3% PM. Differential scanning calorimetry measurement confirmed the complex formation of FRET pairs with PM...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29567258/a-new-strategy-for-choosing-q-markers-via-network-pharmacology-application-to-the-quality-control-of-a-chinese-medical-preparation
#20
Wei Xiang, Tong-Chuan Suo, Hua Yu, An-Ping Li, Shou-Qing Zhang, Chun-Hua Wang, Yan Zhu, Zheng Li
Due to its chemical complexity, proper quality control for a Chinese medical preparation (CMP) has been a great challenge. Choosing the appropriate quality markers (Q-markers) for quality control of CMP is an important work. Best of all, the chosen Q-markers are the main chemical compounds from the herbals as well as the active constituents of this CMP. Only in this way the established quality control system can really achieve the purpose of controlling the quality of CMP and ensuring the safely and effectively use of CMP...
April 2018: Journal of Food and Drug Analysis
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