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Oncology Research and Treatment

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September 20, 2018: Oncology Research and Treatment
Axel Matzdorff, Oliver Meyer, Helmut Ostermann, Volker Kiefel, Wolfgang Eberl, Thomas Kühne, Ingrid Pabinger, Matthias Rummel
No abstract text is available yet for this article.
September 19, 2018: Oncology Research and Treatment
Paolo Aurello, Giammauro Berardi, Laura Antolino, Giulio Antonelli, Alessia Rampini, Giovanni Moschetta, Giovanni Ramacciato
No abstract text is available yet for this article.
September 12, 2018: Oncology Research and Treatment
Suocheng Wei, Luju Lai, Juan Yang, Gong Zhuandi
No abstract text is available yet for this article.
August 27, 2018: Oncology Research and Treatment
Elena D Lavdovskaia, Aglaya G Iyevleva, Anna P Sokolenko, Natalia V Mitiushkina, Elena V Preobrazhenskaya, Vladislav I Tiurin, Alexandr O Ivantsov, Ilya V Bizin, Liliya V Stelmakh, Fedor V Moiseyenko, Nina A Karaseva, Sergey V Orlov, Vladimir M Moiseyenko, Marina A Korzhenevskaya, Ivan A Zaitsev, Andrey R Kozak, Ivan V Chistyakov, Andrey L Akopov, Nikita M Volkov, Alexandr V Togo, Evgeny N Imyanitov
No abstract text is available yet for this article.
August 27, 2018: Oncology Research and Treatment
(no author information available yet)
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
Agnieszka Piekarska, Alicja Sadowska-Klasa, Marta Libura, Karolina Karabin, Andrzej Hellmann
INTRODUCTION: Relapse of acute lymphoblastic leukemia (ALL) after allogeneic hematopoietic cell transplantation (HCT) is a therapeutic challenge. We present the case of a 20-year-old patient with a relapse of Philadelphia chromosome-negative ALL B-common over 2 years after HCT with no response to salvage chemotherapy or blinatumomab, who finally responded to a molecularly tailored therapy adjusted to the BCR-ABL1-like phenotype. METHODS: The BCR-ABL1-like phenotype was diagnosed on the basis of an increased expression of ABL1 and CRLF2 genes...
2018: Oncology Research and Treatment
Mesut Seker, Hayati C Isen, Nidal Çevirme, Sinem Aydın, Ahmet Bilici, Huri Bulut, Ayse I Yasin, Ezgi Coban, Tarık Demir, Altay Aliyev, Abdurrahim Kocyigit, Hacı M Turk
BACKGROUND: The aim of this study was to identify the possible relationship of 5-fluorouracil (5-FU)-related arterial vasoconstriction with urotensin-2 (UT-2), which has a high potential as an endogenic vasoconstrictor. METHODS: We assigned the patients to 1 of 3 groups. Patients in group 1 received a bolus of 5-FU, those in group 2 a continuous infusion (CI) of 5-FU, and those in group 3 no 5-FU, which was also a control group. Pre- and post-treatment UT-2 levels and brachial arterial diameters were measured and recorded in all patients...
2018: Oncology Research and Treatment
Stephanie-Susanne Stecher, Georg Beyer, Elisabetta Goni, Johanna Tischer, Tobias Herold, Christoph Schulz, Mark Op den Winkel, H Joachim Stemmler, Stephanie Lippl
AIMS: The acute respiratory distress syndrome (ARDS) is a frequent condition following pneumonia in immunocompromised cancer patients. Extracorporeal membrane oxygenation (ECMO) may serve as a rescue therapy in refractory ARDS but has still not been studied in predominantly leuco- and thrombocytopenic cancer patients. PATIENTS AND METHODS: In this monocentric, retrospective, observational study, we assessed all cancer patients treated with ECMO for ARDS between 2013 and 2017...
2018: Oncology Research and Treatment
Tanja N Stüber, Stephanie Stangl, Christian Jackisch, Wolfgang Janni, Sara Y Brucker, Andreas Hartkopf, Bernd Gerber, Wilfried Budach, Michael P Lux, Achim Wöckel
PURPOSE: Our aim was to implement a structured literature search using PICO (patient/intervention/comparison/outcome) questions and a standardized consensus method for the German Guideline 'Detection, diagnostics, therapy and follow-up of Breast Cancer' using, as an example, the significance of systemic therapy in lymph node recurrent disease (LNRD). METHODS: We defined specified PICO questions according to the clinical significance of a recommendation for systemic therapies in locoregional LNRD...
2018: Oncology Research and Treatment
Hande Bas Ayata, Cemile Ceylan, Ayhan Kılıç, Metin Güden, Kayıhan Engin
AIM: The purpose of this study was to compare 6 treatment planning methods (5-beam coplanar intensity-modulated radiotherapy (IMRT), 7-beam coplanar IMRT, 7-beam noncoplanar IMRT, 2 full arc coplanar volumetric modulated arc therapy (VMAT), 2 half partial arc coplanar VMAT, and 2 half partial arc noncoplanar VMAT) for high-grade gliomas with planning target volumes (PTVs) overlapping the optic pathway and/or brainstem. PATIENTS AND METHODS: 27 previously-treated patients with high-grade gliomas were replanned for treatment with IMRT5, IMRT7, IMRT7-non, VMAT2f, VMAT2h, and VMAT2h-non...
2018: Oncology Research and Treatment
Amin T Turki, Wolfgang Lamm, Tobias Liebregts, Ulrich Dührsen
For patients aged 60 years or older, the treatment of relapsed aggressive B-cell lymphomas remains challenging. The purpose of this retrospective analysis was to evaluate the results of the R-ICE (rituximab, ifosfamide, carboplatin, etoposide) protocol alone as compared to R-ICE followed by high-dose chemotherapy with autologous transplantation. The 3-year progression-free survival (PFS) and overall survival (OS) rates in 17 patients receiving R-ICE without transplantation were 32% (95% confidence interval (CI): 8...
2018: Oncology Research and Treatment
Diego Kauffmann-Guerrero, Kathrin Kahnert, Zulfiya Syunyaeva, Amanda Tufman, Rudolf M Huber
BACKGROUND: Despite initial response to chemotherapy, the prognosis of small cell lung cancer (SCLC) patients is limited. Following first-line therapy, the strongest predictor of durable progression-free survival (PFS) is remission quality. Febrile neutropenia (FN) is a frequent complication after chemotherapy, and its prevention could improve treatment density and degree of remission. PATIENTS AND METHODS: We retrospectively analyzed 39 SCLC patients treated at a German tertiary care lung cancer center between 2013 and 2016...
2018: Oncology Research and Treatment
Katrin Hardoerfer, Elisabeth Jentschke
BACKGROUND: Many cancer patients suffer from symptoms of anxiety, depression, and fatigue. Supportive treatments are increasingly used to alleviate distress in cancer. In this study, the effects of yoga on these symptoms are examined. METHODS: We performed a randomized controlled study on cancer patients with mixed diagnoses comparing yoga therapy with a waiting list control group. We measured anxiety symptoms with the General Anxiety Disorder (GAD-7) scale, depressive symptoms with the Patient Health Questionnaire-2 (PHQ-2), and fatigue with the European Organisation for Research and Treatment of Cancer Fatigue scale (EORTC QLQ-FA13)...
2018: Oncology Research and Treatment
Carsten Bokemeyer, Reinhard Busse, Jutta Engel, Alexander Gebauer, Michael Hallek, Volker Heinemann, Diana Lüftner, Bernhard Wörmann
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
Michael Hallek, Carsten Bokemeyer, Diana Lüftner, Florian Weissinger
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
Kemal Güngördük, Zeliha Firat Cüylan, Ilker Kahramanoglu, Tufan Oge, Ozgur Akbayir, Murat Dede, Salih Taşkın, Nejat Ozgul, Tayup Simsek, Hasan Turan, Varol Gülseren, Aykut Ozdemir, Mehmet M Meydanlı, Ali Ayhan
AIM: The aim of this study was to investigate the risk factors for recurrence in patients with low-risk endometrial cancer (EC). PATIENTS AND METHODS: This retrospective study was performed using 10 gynecological oncology department databases. Patients who met the following criteria were included in the study: (a) endometrioid-type histology, (b) histological grade 1 or 2, (c) no or < 50% myometrial invasion, (d) no intraoperative evidence of extrauterine spread, and (e) the patient underwent at least a pelvic lymphadenectomy...
2018: Oncology Research and Treatment
Louisa T Hami, Bjoern Lampe, Peter Mallmann, Dirk M Forner
INTRODUCTION: Younger women are particularly affected by the increase in the incidence of vulvar cancer. The purpose of this study was to investigate how clinical characteristics differ depending on the patient´s age and what role the age of initial diagnosis plays in the prognosis. Patients andMethods: Included patients were divided into groups aged below or above 50 years. The disease-free survival (DFS) was calculated and a multivariate discriminant analysis was conducted. RESULTS: Of the 300 patients, 79 were ≤50 years and 221 were >50 years...
2018: Oncology Research and Treatment
Tatjana Gruber-Rouh, Ahmed Kamal, Katrin Eichler, Nagy N Naguib, Martin Beeres, Marcel Langenbach, Thomas J Vogl
BACKGROUND: We evaluated survival data and local tumor control in 2 groups of patients with hepatocellular carcinoma (HCC) treated with different chemotherapeutic agents for transarterial chemoembolization (TACE). METHODS: 28 patients (median age 63 years) with HCC were repeatedly treated with chemoembolization at 4-week intervals. 20 patients had Barcelona Clinic Liver Cancer (BCLC) stage B, while 8 patients obtained chemoembolization for bridging purposes (BCLC stage A)...
2018: Oncology Research and Treatment
Baki Erdem, Ilkbal T Yüksel, Nuri Peker, Suat C Ulukent, Osman Aşıcıoğlu, Ipek Y Özaydin, Volkan Ülker, Ozgur Akbayir
BACKGROUND: Systematic lymphadenectomy is useful for accurate staging of early-stage ovarian cancer and has obvious prognostic value. Accurate staging may prevent unnecessary postoperative chemotherapy. The aim of this study was to evaluate the rate of lymph node involvement and factors affecting it in clinically early-stage epithelial ovarian cancer (EOC; stages I, II). PATIENTS AND METHODS: The study included 163 patients who underwent surgery at our hospital between January 2004 and April 2017 and who were diagnosed with early-stage EOC based on preoperative and intraoperative examination...
2018: Oncology Research and Treatment
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