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Oncology Research and Treatment

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https://www.readbyqxmd.com/read/30419566/patients-perspective-what-has-changed-in-deciding-about-breast-conserving-surgery-for-early-stage-breast-cancer-in-turkey
#1
Ergün Yüksel, H Erhan Güven, Lütfi Dogan
BACKGROUND: This study aims to describe patients' perception of early breast cancer, factors influencing the choice of operation, patients' sources of information about the disease and the seriousness with which this information is considered, and to address what surgeons can do to enlighten their patients prior to decision-making. METHODS: Patients were asked to complete a questionnaire consisting of 3 sections: The first section addressed influential factors during the decision-making process; the second pertained to the role of surgeons or health facilities in the process; and the third asked patients to revisit their initial choice of surgery...
November 13, 2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30419558/neutrophil-to-lymphocyte-ratio-as-a-prognostic-factor-in-european-patients-with-epidermal-growth-factor-receptor-mutant-non-small-cell-lung-cancer-treated-with-tyrosine-kinase-inhibitors
#2
David Aguiar-Bujanda, Arancha Dueñas-Comino, Salvador Saura-Grau, Laura Ros-Sanjuan, Maria J Blanco-Sanchez, Maria Hernandez-Sosa, Marta Mori-De Santiago, Saray Galvan-Ruiz, Jose E Lorenzo-Barreto, Ana M Vargas-Prado, Uriel Bohn-Sarmiento
BACKGROUND: A high neutrophil to lymphocyte ratio (NLR) has been associated with adverse outcomes in non-small cell lung cancer (NSCLC). However, information on epidermal growth factor receptor (EGFR)-mutant advanced NSCLC is scarce, and most of the studies published have been conducted in Asian populations. We aimed to assess the influence of pretreatment NLR on progression-free survival (PFS) and overall survival (OS) in Western European patients treated with EGFR tyrosine kinase inhibitors (TKIs)...
November 13, 2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30419557/risk-factors-for-lymph-node-metastasis-among-lymphovascular-space-invasion-positive-women-with-endometrioid-endometrial-cancer-clinically-confined-to-the-uterus
#3
Mustafa Erkan Sarı, Mehmet Mutlu Meydanlı, Ibrahim Yalçın, Hanifi Şahin, Gonca Çoban, Hüsnü Çelik, Esra Kuşçu, Tayfun Gungor, Ali Ayhan
INTRODUCTION: We aimed to assess risk factors for lymph node (LN) metastasis among lymphovascular space invasion(LVSI)-positive women with pure endometrioid endometrial cancer (EC) clinically confined to the uterus. METHODS: Medical records of women who underwent primary surgery for EC between 2007 and 2016 at either of 2 gynecological oncology centers were retrospectively reviewed. Patient data were analyzed with respect to LN involvement, and predictive factors for LN metastasis were investigated...
November 13, 2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30419553/efficacy-of-carboplatin-paclitaxel-based-radiochemotherapy-in-locally-advanced-squamous-cell-carcinoma-of-head-and-neck
#4
Stephan Maring, Khaled Elsayad, Markus Stenner, Claudia Rudack, Uwe Haverkamp, Jan Rehkämper, Eva Wardelmann, Hans T Eich
BACKGROUND: Cisplatin-based chemotherapy (CTX) is commonly used concurrently with radiotherapy for head and neck cancer. The value of CTX regimens other than cisplatin for locally advanced squamous cell carcinoma of head and neck (LASCCHN) has not been well established. Here we compare the outcome of patients treated with different platinum-based chemotherapy regimens. METHODS: Medical records from 104 patients with LASCCHN treated with radiochemotherapy (RCTX) between February 2013 and August 2016 were analyzed...
November 13, 2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30261496/jahrestagung-der-deutschen-%C3%A3-sterreichischen-und-schweizerischen-gesellschaften-f%C3%A3-r-h%C3%A3-matologie-undmedizinische-onkologie-wien-28-september-2-oktober-2018-abstracts
#5
(no author information available yet)
No abstract text is available yet for this article.
September 28, 2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30372703/meetings-and-conferences
#6
(no author information available yet)
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30372702/society-bulletins
#7
(no author information available yet)
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30372701/pharmanews
#8
(no author information available yet)
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30372700/editorial-board-contents-imprint
#9
(no author information available yet)
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30326471/uterine-sarcoma-difficult-to-diagnose-hard-to-treat
#10
Peter Mallmann
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30326467/uterine-adenosarcoma
#11
Uwe A Ulrich, Dominik Denschlag
Uterine adenosarcoma is a rare malignancy. It is defined as a biphasic tumor composed of both sarcomatous stroma and benign epithelium. While the sarcomatous component usually is a low-grade homologous uterine sarcoma, the epithelium most often consists of endometrium-like cells. If the sarcomatous part occupies more than 25% of the tumor volume, the situation is referred to as sarcomatous overgrowth - accounting for about 10% of cases. While adenosarcoma usually may be considered a tumor of low malignant potential, the sarcomatous overgrowth most often presents as high-grade sarcoma and is associated with aggressive clinical behavior...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30321870/association-between-mri-features-and-standardized-uptake-value-of-18f-fdg-pet-ct-in-triple-negative-breast-cancer
#12
Bo Bae Choi, Jin Sun Lee, Kun Ho Kim
BACKGROUND: Triple-negative breast cancer (TNBC) is a breast cancer subgroup that lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Certain magnetic resonance imaging (MRI) features of TNBC might reflect the poor prognosis of TNBC. Standardized uptake value (SUV) of [18F]fluorodeoxyglucose positron emission tomography/computed tomography is 1 of predictive prognostic factors for breast cancer. The purpose of this study was to correlate MRI features of TNBC with SUVmax to determine whether MRI findings in TNBC could be helpful for predicting prognosis...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30321869/uterine-leiomyosarcoma
#13
Ingolf Juhasz-Böss, Lena Gabriel, Rainer M Bohle, Lars C Horn, Erich-Franz Solomayer, Georg-Peter Breitbach
Uterine leiomyosarcoma (uLMS) is a rare entity among malignant gynecologic tumors with a very unfavorable prognosis and the highest prevalence in the pre- and peri-menopause. Only early-stage tumors have an acceptable prognosis, provided the patient has been treated without injuring the uterus. uLMS is often diagnosed accidentally and the correct diagnosis ishampered by equivocal features similar to the far more frequent benign uterine fibroids. Surgery is the basis of therapy, and it should be done in order to remove the uterus intact...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30317238/low-grade-endometrial-stromal-sarcoma-a-review
#14
Falk C Thiel, Sonja Halmen
Like other uterine sarcomas, low-grade endometrial stromal sarcomas (LG-ESS) are a very rare tumor entity. In the past, research studies therefore discussed the various different types of the disease in combination. In addition, the classification of endometrial stromal tumors presented difficulties for quite some time so that in earlier studies it was not always possible to precisely distinguish between LG-ESS, high-grade endometrial stromal sarcoma, and undifferentiated uterine sarcoma. For LG-ESS, surgery with hysterectomy and adnexectomy is the first-line treatment...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30317236/single-fraction-stereotactic-body-radiotherapy-for-oligometastatic-lymph-node-relapse-in-prostate-cancer
#15
Mauro Loi, Vanessa Di Cataldo, Giulio Francolini, Pierluigi Bonomo, Laura Masi, Gabriele Simontacchi, Beatrice Detti, Daniela Greto, Isacco Desideri, Lorenzo Livi
BACKGROUND: Stereotactic body radiotherapy (SBRT) emerged as a treatment option in oligometastatic (≤3 metastases) patients experiencing lymph node relapse from treated prostate cancer. No recommendations are available concerning dose schedule, and available studies report the use of multiple-fraction regimens due to theoretical lower toxicity and higher cumulative dose delivered to the target. The aim of the present study was to evaluate the safety and efficacy of a dose-intensive, single-fraction SBRT regimen...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30317235/hematological-toxicity-of-hypofractionated-radiotherapy-a-review-of-the-available-evidence
#16
Mateusz Spałek, Lucjan Wyrwicz
Hypofractionated radiotherapy is commonly used to treat many cancers. The number of indications for this fractionation schedule is increasing. Knowledge of the potential hematological toxicity arising from hypofractionated irradiation is vital since many patients receive further systemic treatment. This review analyzes the available evidence on the effect of hypofractionated radiotherapy on hematological toxicity. However, radiobiological data on bone marrow responses to high doses of radiation per fraction are sparse...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30317231/uterine-carcinosarcomas-diagnosis-and-management
#17
Dominik Denschlag, Uwe A Ulrich
Uterine carcinosarcomas are rare tumors that account for less than 5% of all uterine malignancies. These tumors (previously called malignant mixed Müllerian tumors) are dedifferentiated carcinomas that comprise carcinomatous and sarcomatous elements and arise from a single malignant clone. They are considered a high-risk variant of endometrial adenocarcinoma because carcinosarcomas share more similarities in epidemiology, risk factors, and clinical behavior with endometrial carcinoma than with uterine sarcomas...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30317227/return-to-work-in-patients-with-hematological-cancers-1-year-after-treatment-a-prospective-longitudinal-study
#18
Tim J Hartung, Leon P Sautier, Angela Scherwath, Kirsten Sturm, Nicolaus Kröger, Uwe Koch, Anja Mehnert
BACKGROUND: Although hematological cancer survivors have a high risk of disability, data on work-related issues are scarce for this population. METHODS: We investigated return to work (RTW) and work ability (Work Ability Index, WAI) in hematological cancer patients 6 months and 1 year after cancer treatment. We explored associations between baseline sociodemographic and medical characteristics and RTW as well as work ability at follow-up. RESULTS: The participation rate was 42% (baseline n = 91, after 12 months n = 40 (44%))...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30286478/cell-free-dna-and-neuromediators-in-detecting-aggressive-variant-prostate-cancer
#19
Jost von Hardenberg, Thomas S Worst, Niklas Westhoff, Philipp Erben, Stefan Fuxius, Markus Müller, Christian Bolenz, Christel Weiss, Elmar Heinrich
BACKGROUND: Aggressive variant transformation in metastatic castration-resistant prostate cancer (mCRPC) represents an under-recognized phenomenon. There is an urgent need for non-invasive biomarkers to detect these variants and identify treatment alternatives. METHODS: A prospective observational pilot study in mCRPC patients receiving treatment with cabazitaxel (CAB) was conducted. Neuromediators were sequentially evaluated and their impact on disease endpoints calculated...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/30286477/meetings-and-conferences
#20
(no author information available yet)
No abstract text is available yet for this article.
2018: Oncology Research and Treatment
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