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Oncology Research and Treatment

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https://www.readbyqxmd.com/read/28324876/re-irradiation-of-locoregional-nsclc-recurrence-using-robotic-stereotactic-body-radiotherapy
#1
Cemile Ceylan, Andaç Hamacı, Hande Ayata, Kezban Berberoglu, Ayhan Kılıç, Metin Güden, Kayıhan Engin
No abstract text is available yet for this article.
March 9, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28324883/met-amplification-and-response-to-met-inhibitors-in-stage-iv-lung-adenocarcinoma
#2
Moushumi Suryavanshi, Aekta Shah, Dushyant Kumar, Manoj K Panigrahi, Anurag Metha, Ullas Batra
No abstract text is available yet for this article.
March 8, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28273669/hiv-associated-malignancies
#3
Kai Hübel
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28273666/prophylaxis-and-treatment-of-cancer-associated-venous-thromboembolism-comparison-hematologist-oncologists-versus-angiologist-phlebologists
#4
Axel Matzdorff, Bettina Ledig, Markus Stücker, Hanno Riess
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28259889/erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28259888/hiv-associated-kaposi-s-sarcoma
#6
Christian Hoffmann, Michael Sabranski, Stefan Esser
Kaposi's sarcoma (KS) is still one of the most common malignancies in patients with human immunodeficiency virus (HIV) infection. Large randomized clinical trials have shown a protective effect of combination antiretroviral therapy (cART) against the development of KS, even in patients with a relatively preserved immune system. In patients with sufficient cART, KS has become a rarity. In most patients with HIV-associated KS who initiate cART, the KS lesions stabilize with decreasing HIV plasma viremia and immune reconstitution, or even resolve completely without any specific treatment...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28259887/hiv-associated-lung-cancer
#7
Til R Kiderlen, Jan Siehl, Marcus Hentrich
Lung cancer (LC) is one of the most common non-AIDS (acquired immune deficiency syndrome)-defining malignancies. It occurs more frequently in persons living with human immunodeficiency virus (PLWHIV) than in the HIV-negative population. Compared to their HIV-negative counterparts, patients are usually younger and diagnosed at more advanced stages. The pathogenesis of LC in PLWHIV is not fully understood, but immunosuppression in combination with chronic infection and the oncogenic effects of smoking and HIV itself all seem to play a role...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28253522/hiv-associated-anal-dysplasia-and-anal-carcinoma
#8
Mark Oette, Franz A Mosthaf, Marie-Luise Sautter-Bihl, Stefan Esser
Anal carcinoma shows an increasing incidence in people living with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) in whom it is also much more common compared to the HIV-negative population. Human papillomavirus infection is the etiological basis of malignant development in the anal epithelium. Therefore, adequate diagnosis and treatment of the precursor lesions (anal intraepithelial neoplasia) is of clinical importance. In cases with preserved immune function, anal cancer can be treated according to guidelines issued for HIV-negative patients...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28253521/hiv-associated-gastrointestinal-cancer
#9
Björn E-O Jensen, Mark Oette, Johannes Haes, Dieter Häussinger
People living nowadays with HIV and AIDS may be treated effectively regarding virus replication and immunology. However, non-AIDS-defining cancer is of growing relevance due to high incidence and unfavorable outcome. The aim of this review is to summarize current knowledge on gastrointestinal (GI) carcinoma. Although literature on GI cancer is rare, an increased incidence of esophageal, gastric, pancreatic, hepatocellular, and colorectal carcinoma has been demonstrated. However, there are only few reports on therapy strategies and outcome, so that, despite increased occurrence of many GI carcinomas, only little is known about individualized treatment options and outcome in HIV-positive patients...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28253516/hiv-associated-malignant-lymphoma
#10
Uta Brunnberg, Marcus Hentrich, Christian Hoffmann, Timo Wolf, Kai Hübel
Acquired immune deficiency syndrome (AIDS)-related lymphomas (ARL) still represent a relevant field of clinical research. For most histological subtypes of ARL, no optimal initial therapy has been clearly defined so far. Rituximab plus chemotherapy is feasible and effective and should be offered to all patients with CD20-positive ARL regardless of their CD4 cell count. Combination antiretroviral therapy (cART) should be given concomitantly with chemotherapy, bearing in mind potential drug-drug interactions...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28253510/hiv-associated-urogenital-malignancies
#11
Marcus Hentrich, David Pfister
Non-AIDS-defining malignancies (NADM) are a leading cause of morbidity and mortality for HIV-infected subjects. The risk of testicular germ cell cancer (GCC) and renal cell cancer is slightly increased in the setting of HIV, whereas there is a slightly decreased risk of prostate cancer and bladder cancer. As in industrialized countries the majority of people living with HIV are men, and people aged 55 and older now account for more than a quarter of persons living with HIV, both testis and prostate cancer are assumed to occur with increased frequency in HIV-infected subjects...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28253501/drug-interactions-in-the-treatment-of-malignancy-in-hiv-infected-patients
#12
Tanya Welz, Christoph Wyen, Manfred Hensel
The number of patients with HIV (human immunodeficiency virus) requiring treatment for malignancy is increasing worldwide. Concurrent treatment of HIV and malignancy is complicated by unpredictable drug-drug interactions, which can cause potentially life-threatening toxicities and ineffective treatment of either disease. This article aims to provide a practical approach to drug interactions and their management in this context to help deliver effective and safe treatment of both the malignancy and HIV.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28231593/long-term-relief-of-cerebral-radiation-necrosis-treated-with-low-dose-bevacizumab-a-report-of-2-cases
#13
Qiongge Hu, Juan Zhao, Jing Xu, Xiaofeng Zhou, Yongjie Shui, Li Shen, Qichun Wei
BACKGROUND: Radiation necrosis is 1 of the most significant complications of brain tumor irradiation. The standard treatment for patients with radiation necrosis consists of corticosteroids to reduce the amount of cerebral edema and, if required, cyst drainage. CASE REPORTS: 2 patients with symptomatic radiation necrosis initially unresponsive to steroid treatment were treated with repeated low-dose bevacizumab at 5 mg/kg body weight. Rapid and lasting symptom relief, as well as neuroradiological improvement was seen in both cases...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28192780/baseline-and-on-treatment-markers-determining-prognosis-of-first-line-chemotherapy-in-combination-with-bevacizumab-in-patients-with-metastatic-colorectal-cancer
#14
Julia Quidde, Laura Denne, Andreas Kutscheidt, Manfred Kindler, Andreas Kirsch, Melanie Kripp, Volker Petersen, Matthias Schulze, Jörg Seraphin, Dirk Tummes, Dirk Arnold, Alexander Stein
BACKGROUND: In metastatic colorectal cancer, no upfront or on-treatment markers are available to determine the prognosis or efficacy for chemotherapy in combination with bevacizumab. PATIENTS AND METHODS: The current analysis was performed to evaluate the prognostic value of disease and patient characteristics (age, number of metastatic sites, stage of primary tumor, performance status, carcinoembryonic antigen (CEA)) and on-treatment changes of CEA (response after 8-12 weeks of treatment and specific patterns of CEA kinetics) in patients from an observational cohort study of chemotherapy with bevacizumab...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28142132/-konsensusempfehlungen-deutscher-experten-management-der-therapie-mit-idelalisib
#15
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28142131/meetings-and-conferences
#16
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28118648/increased-expression-of-mir-29a-and-its-prognostic-significance-in-patients-with-cholangiocarcinoma
#17
Yingbin Deng, Yuxin Chen
BACKGROUND: This study aimed to examine the expression level and prognostic value of microRNA-29a (miR-29a) in human cholangiocarcinoma (CCA). PATIENTS AND METHODS: The expression of miR-29a was measured in tissues collected from 125 CCA patients using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Survival analysis was carried out using the Kaplan-Meier method and log-rank test. The prognostic value of miR-29a was examined with Cox regression analysis...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28118647/relationship-between-carnitine-pharmacokinetics-and-fatigue-in-patients-treated-with-cisplatin-containing-chemotherapy
#18
Tomoaki Ikezaki, Kensuke Suzuki, Kenta Kambara, Minehiko Inomata, Seisuke Okazawa, Shinya Kajiura, Toshiro Miwa, Kouichi Tanabe, Tatsuhiko Kashii
BACKGROUND: Approximately 70% of the patients who receive chemotherapy suffer from fatigue, which lowers their quality of life and also has a negative influence on therapeutic efficacy. Previous studies have suggested a relationship between blood carnitine levels and fatigue. We conducted a prospective observational study to examine the relationship between carnitine pharmacokinetics and chemotherapy-induced fatigue in patients receiving cancer chemotherapy regimens that include cisplatin...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28118634/clinicopathological-features-and-therapeutic-responses-of-chinese-patients-with-advanced-lung-adenocarcinoma-harboring-an-anaplastic-lymphoma-kinase-rearrangement
#19
De Zeng, Danxia Lin, Chen Chen, Xiao Wu, Miaojun Wang, Jiongyu Chen, Hui Lin, Xihui Qiu
BACKGROUND: Presence of anaplastic lymphoma kinase (ALK) rearrangement is an indication for crizotinib in the treatment of patients with advanced or metastatic lung adenocarcinoma. Here, we sought to elucidate the association between clinicopathological features and ALK rearrangement status in Chinese patients with advanced lung adenocarcinoma harboring an ALK rearrangement. PATIENTS AND METHODS: ALK rearrangement status was determined using immunohistochemistry (IHC) in tumor tissues from 120 patients with advanced lung adenocarcinoma, and further assessed by fluorescence in situ hybridization (FISH) assay...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28118631/impact-of-egfr-tyrosine-kinase-inhibitors-on-postoperative-recurrent-non-small-cell-lung-cancer-harboring-egfr-mutations
#20
Satoshi Igawa, Shiichiro Ryuge, Masaaki Ichinoe, Hiroyasu Nakashima, Sakiko Otani, Yoshiro Nakahara, Tomoya Fukui, Jiichiro Sasaki, Masaru Kubota, Masato Katagiri, Yoshiki Murakumo, Yukitoshi Satoh, Yuichi Sato, Noriyuki Masuda
BACKGROUND: It is unclear whether there is a difference in the efficacy of treatment by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) between patients with postoperative recurrent non-small-cell lung cancer (NSCLC) and those with stage IV NSCLC harboring EGFR mutations. PATIENTS AND METHODS: The records of NSCLC patients harboring EGFR mutations who were treated with gefitinib or erlotinib were retrospectively reviewed, and the treatment outcomes were evaluated...
2017: Oncology Research and Treatment
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