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Oncology Research and Treatment

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https://www.readbyqxmd.com/read/28628916/comprehensive-biomarker-analyses-in-patients-with-advanced-or-metastatic-non-small-cell-lung-cancer-prospectively-treated-with-the-polo-like-kinase-1-inhibitor-bi2536
#1
Frank Breitenbuecher, Joachim von Pawel, Martin Sebastian, Cornelius Kortsik, Saskia Ting, Stefan Kasper, Jeremias Wohlschläger, Karl Worm, Alicia Morresi-Hauf, Arno Schad, Daniela Westerwick, Beatrice Wehler, Martin Werner, Gerd Munzert, Birgit Gaschler-Markefski, Kurt W Schmid, Martin Schuler
No abstract text is available yet for this article.
June 20, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28578338/pharmanews
#2
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28578337/pharmanews
#3
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28578336/pharmanews
#4
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28578335/pharmaforum
#5
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28578334/pharmaforum
#6
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28578333/pharmaforum
#7
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28578332/editorial-board-contents-imprint
#8
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28558385/risk-factors-for-overall-survival-outcome-in-surgically-treated-human-papillomavirus-negative-and-positive-patients-with-oropharyngeal-cancer
#9
Nora Wuerdemann, Claus Wittekindt, Shachi Jenny Sharma, Elena-Sophie Prigge, Miriam Reuschenbach, Stefan Gattenlöhner, Jens Peter Klussmann, Steffen Wagner
INTRODUCTION: This study reports the oncological outcome of a non-selected series of patients with human papillomavirus(HPV)-positive and -negative oropharyngeal squamous cell carcinoma (OSCC) preferentially managed with upfront surgery. METHODS: Consecutive OSCC cases (n = 378) diagnosed from 2000 to 2010 in our department were evaluated for risk factors, HPV association, therapy and overall survival (OS). HPV status was determined by combined DNA and p16 testing, and treatment was defined as the first course of treatment with any kind of surgery (upfront surgery) or primary chemoradiotherapy...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28531899/epidemiology-and-molecular-biology-of-head-and-neck-cancer
#10
Adriana Jou, Jochen Hess
Head and neck cancer is a common and aggressive malignancy with a high morbidity and mortality profile. Although the large majority of cases resemble head and neck squamous cell carcinoma (HNSCC), the current classification based on anatomic site and tumor stage fails to capture the high level of biologic heterogeneity, and appropriate clinical management remains a major challenge. Hence, a better understanding of the molecular biology of HNSCC is urgently needed to support biomarker development and personalized care for patients...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28531886/malignancy-in-solitary-thyroid-nodules-evaluation-of-risk-factors
#11
Osman Uyar, Bahadır Cetin, Bulent Aksel, Lutfi Dogan, Kemal Beksac, Gokhan G Akgul, Ugur Berberoglu, Mehmet A Gulcelik
BACKGROUND: The aim of the present study was to evaluate patients with suspicious solitary nodules undergoing bilateral total thyroidectomy for the presence of malignancy. PATIENTS AND METHODS: 141 patients with true solitary thyroid nodules who underwent bilateral total thyroidectomy at the Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital between 2008 and 2013 were retrospectively evaluated. Parameters including demographics, ultrasonographic findings, and laboratory values were analyzed...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28521323/head-and-neck-cancer-new-insights-into-a-heterogeneous-disease
#12
Jens Peter Klussmann
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28521322/novel-treatment-options-in-head-and-neck-cancer
#13
Patrick J Schuler, Simon Laban, Johannes Doescher, Lars Bullinger, Thomas K Hoffmann
The treatment of head and neck squamous cell carcinoma (HNSCC) has been a medical challenge with limited improvement in overall survival over the past few decades. However, recently, very interesting innovations in the field of immunotherapy have been shown to be beneficial for patients with advanced HNSCC. In this article, the latest medical developments are reviewed with special focus on the clinical achievements and current clinical studies in the field of immunotherapy. The landscape of clinical studies has changed considerably from antibody-based growth factor inhibition towards immune checkpoint modulation, and new indications in the adjuvant and neoadjuvant setting are being tested in large patient cohorts...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28521321/the-role-of-radiotherapy-in-the-definitive-and-postoperative-treatment-of-advanced-head-and-neck-cancer
#14
Robert Semrau
Radiotherapy plays an important role in the treatment of head and neck cancer. It represents the main curative option in advanced tumors. Due to technical progress of treatment appliances, the translation of radiobiological research into clinical praxis (altered fractionation), and the concurrent application of chemotherapy (radiochemotherapy), the efficacy of radiotherapy has markedly improved. Current developments focus on the integration of functional imaging into the treatment planning process to allow individualized dose prescription...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28521311/human-papillomavirus-related-head-and-neck-cancer
#15
Steffen Wagner, Shachi Jenny Sharma, Nora Wuerdemann, Jennifer Knuth, Henrike Reder, Claus Wittekindt, Jens Peter Klussmann
Human papillomavirus(HPV)-related head and neck cancer is recognized as a distinct tumor entity with rising incidence reported for several countries. These tumors arise from squamous cells, typically in the oropharynx. In contrast to cancer associated with other risk factors, HPV-related cancer is driven by viral oncoprotein activity and has individual profiles regarding protein expression, and genetic and epigenetic alterations. Molecular characteristics are p16IN4A overexpression, absence of p53 inactivating mutations, and PI3K/AKT and Wnt pathway modulation...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28501860/single-center-experience-with-intimal-sarcoma-an-ultra-orphan-commonly-fatal-mesenchymal-malignancy
#16
Julie Van Dievel, Raf Sciot, Marion Delcroix, Raf O Vandeweyer, Maria Debiec-Rychter, Barbara Dewaele, Jasmien Cornillie, Thomas Van Cann, Bart Meyns, Patrick Schöffski
BACKGROUND: Intimal sarcoma is a rare malignancy that, clinically and radiographically, often mimics pulmonary embolism. The intravascular tumor tends to disseminate rapidly and metastases can be present at first diagnosis. METHODS: We reviewed all cases of intimal sarcoma that were diagnosed, treated and followed at the University Hospitals Leuven between April 2006 and April 2016. RESULTS: We identified 13 patients with a median age of 51 years...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28482344/norad-expression-is-associated-with-adverse-prognosis-in-esophageal-squamous-cell-carcinoma
#17
Xiaoliang Wu, Zuan-Fu Lim, Zhongwen Li, Ling Gu, Wenjuan Ma, Qianghua Zhou, Huifang Su, Xing Wang, Xianzi Yang, Zhenfeng Zhang
BACKGROUND: NORAD (non-coding RNA-activated by DNA damage) is a conserved, abundant, and broadly expressed long non-coding RNA, which functions to preserve genome stability. However, its prognostic significance in esophageal squamous cell carcinoma (ESCC) remains unclear. MATERIAL AND METHODS: The expression of NORAD was detected by quantitative real-time polymerase chain reaction in pairs of tumorous and adjacent normal tissues derived from 106 ESCC patients. We analyzed the potential relationship between NORAD expression levels in tumor tissues and clinicopathological features of ESCC patients and clinical outcome...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28472807/clinical-features-and-treatment-outcome-of-malignant-pleural-mesothelioma
#18
Manlio Mencoboni, Rosa A Filiberti, Paola Taveggia, Federica Grosso, Giulia Pasello, Lisette Del Corso, Alberto Muzio, Valentina Polo, Paolo Zucali, Giovanni L Ceresoli, Hector J Soto Parra, Laura Auriati, Claudio Simonassi
BACKGROUND: Malignant pleural mesothelioma is a problematic condition due to poor prognosis and difficulties in management. We evaluated the treatment and outcome of 378 mesothelioma patients referred to 6 Italian Oncology Departments. METHODS: Demographic and clinical data were collected. Treatment was assessed in terms of chemotherapy (line of treatment, pemetrexed-based regimen, other therapies), surgery, and radiotherapy. Response to therapy, progression-free survival, and overall survival were evaluated...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28448996/pharmanews
#19
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28448992/bethesda-made-it-clearer-a-review-of-542-patients-in-a-single-institution
#20
Yunus Acar, Lütfi Doğan, H Erhan Güven, Bülent Aksel, Niyazi Karaman, Cihangir Özaslan, M Ali Gülçelik
BACKGROUND: It is essential to interpret fine needle aspiration biopsy (FNAB) material correctly to create a common language among pathologists and surgeons, leading to a uniform approach to thyroid nodule management. We aimed to compare FNAB reports of patients at our institution who were treated with total thyroidectomy, before and after the Bethesda classification system. PATIENTS AND METHODS: Patients who underwent total thyroidectomy for thyroid nodules are reviewed...
2017: Oncology Research and Treatment
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