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Oncology Research and Treatment

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https://www.readbyqxmd.com/read/29151110/family-oriented-rehabilitation-for-and-rehabilitation-of-adolescents-and-young-adults-aya-in-pediatric-oncology
#1
Konstantin A Krauth
No abstract text is available yet for this article.
November 20, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183040/oncological-rehabilitation
#2
Oliver Rick, Timm Dauelsberg, Eva-Maria Kalusche-Bontemps
An increasing number of patients are living with or surviving cancer due to improvements in detection and treatment. However, patients who survive cancer may experience functional disabilities that impact on health, quality of life and ability to work. For example, physical disorders may include fatigue, reduced muscle strength, cognitive dysfunction, paresthesia or nutrition problems, while mental symptoms may include anxiety, depression, fear of relapse or insomnia. Multidimensional oncological rehabilitation programs have been developed to address these disabilities and to help cancer patients and long-term survivors to reduce morbidity and to improve quality of life...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183038/acknowledgement-to-reviewers
#3
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183034/adjuvant-radiotherapy-in-high-risk-squamous-cell-carcinoma-of-the-vulva-a-two-institutional-italian-experience
#4
Concetta Laliscia, Maria G Fabrini, Ines Cafaro, Amelia Barcellini, Davide Baldaccini, Mario Miniati, Emanuela Parietti, Riccardo Morganti, Fabiola Paiar, Angiolo Gadducci
BACKGROUND: The aim of this study was to assess the treatment benefit and patterns of recurrence for patients with high-risk vulvar squamous cell carcinoma treated with surgery followed by adjuvant radiotherapy (RT). PATIENTS AND METHODS: From January 1999 to June 2016, 51 patients underwent total or partial deep vulvectomy with inguinofemoral lymphadenectomy followed by adjuvant RT with 45-50 Gy in 25 fractions +/- a 4-10 Gy boost. 17 (33.3%) women received concomitant chemotherapy...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183033/the-functional-assessment-of-chronic-illness-therapy-fatigue-facit-fatigue-subscale-validity-and-reliability-of-the-iranian-version
#5
Alipasha Meysami, Hossein Yari, Shahpar Haghighat, Ali Montazeri
BACKGROUND: The aim of this study was to translate and validate the Functional Assessment of Chronic illnesses Therapy-Fatigue (FACIT-fatigue subscale) in Iran. METHODS: The Persian version of the FACIT-fatigue scale was developed using the forward-backward translation method. The questionnaire was then presented to a consecutive sample of breast cancer patients (n = 208) attending the Iranian Center of Breast Cancer (ICBC). The reliability was assessed by internal consistency and test-retest using Cronbach's α and intraclass correlation coefficient (ICC), respectively...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183032/return-to-work-of-cancer-survivors
#6
Ulf Seifart, Jan Schmielau
Due to improving treatment options, the number of so-called long-term cancer survivors is steadily increasing. Current studies assume that more than 60% of adults survive their cancer. These patients have a variety of problems (chemotherapy-induced neuropathy, fatigue, etc.) that require very special care. In addition to somatic and psychological side effects of the cancer or its treatment, these patients also suffer from the financial and social consequences of the disease. Thus, for a long-term survivor of working age, the question of a 'return to work' represents a significant problem since otherwise the financial existence of the patient, and often the family, may substantially deteriorate...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183029/successful-evidence-based-treatment-of-patients-with-advanced-pancreatic-cancer-in-community-based-oncology-group-practices
#7
Geothy Chakupurakal, Stefan Feiten, Oswald Burkhard, Marcel Reiser, Peter Ehscheidt, Rudolf Weide
BACKGROUND: Randomized clinical trials do not reflect the day-to-day reality of patient care; hence, the treatment of patients with advanced pancreatic cancer in oncology group practices was evaluated. PATIENTS AND METHODS: All consecutive patients with advanced pancreatic cancer who were treated between 01/2012 and 12/2015 in 4 oncology group practices were analyzed retrospectively using SPSS software. RESULTS: 324 patients with a median age of 70 years (range 32-94 years) were analyzed...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183026/late-effects-and-long-term-follow-up-after-cancer-in-childhood
#8
Thorsten Langer, Desiree Grabow, Diana Steinmann, Bernhard Wörmann, Gabriele Calaminus
Today, 80% of children and adolescents with cancer survive their disease. From the results of aftercare research arises the question: Are the survivors also healthy? Many late effects depend on the type of cancer and its treatment. Patients with brain tumors and with malignant sarcomas are very often affected by secondary diseases. Data from the USA report that around 2/3 of all patients still living 30 years after their cancer treatment in childhood suffer from late complications. Equivalent figures for Germany were previously unavailable...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183022/rehabilitation-of-cancer-survivors-with-long-term-toxicities
#9
Jan Schmielau, Oliver Rick, Monika Reuss-Borst, Eva-Maria Kalusche-Bontemps, Monika Steimann
The prognosis of cancer patients is constantly improving, which increases the importance of securing long-term quality of life. While therapy of treatment-related disability mostly succeeds a cancer-specific treatment, physicians' awareness of simultaneous supportive therapy is rising. Early interventions such as physical exercise during chemotherapy are effective in reducing conditions such as fatigue. Specific sensorimotor training is able to improve or even prevent impairment of balance caused by neurotoxic agents...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183019/society-bulletins
#10
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183016/meetings-and-conferences
#11
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29183015/oncological-rehabilitation-and-cancer-survivorship
#12
Oliver Rick, Thorsten Langer
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29080889/meetings-and-conferences
#13
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29080888/society-bulletins
#14
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29069663/specific-adoptive-cellular-immunotherapy-in-allogeneic-stem-cell-transplantation
#15
Stefan Audehm, Angela M Krackhardt
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents a treatment option for a diversity of advanced hematopoietic malignancies providing hope for long-term responses especially due to immunogenic effects associated with the treatment modality. Despite respectable progress in the field, relapses and/or opportunistic infections are major reasons for the high treatment-related mortality. However, a number of novel immunotherapeutic approaches using defined cell populations have been developed to directly target residual malignant cells as well as defined infectious diseases...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065424/checkpoint-inhibition-in-hodgkin-lymphoma-a-review
#16
Paul J Bröckelmann, Andreas Engert
Physiological immune checkpoint pathways are important to regulate self-tolerance, limit immune reactions, and moderate autoimmunity. Various cancers are commonly exploiting these mechanisms to evade the host immune system by restraining a durable, efficient anti-tumor immune response. Immune checkpoints include, but are not limited to, the programmed death 1 (PD1) and the cytotoxic T-lymphocyte-associated protein-4 (CTLA4) axis, which are both druggable by monoclonal antibodies referred to as checkpoint inhibitors (CIs)...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065421/checkpoint-inhibition-in-non-hodgkin-s-lymphoma
#17
Georg Heß
As patients continue to die from malignant lymphoma, novel treatment options continue to be warranted. To successfully grow and spread, tumor cells need to escape the immune system; therefore, the augmentation or restoration of immune effectors against the malignant cell could be of great value, as shown, e.g., for allogeneic transplantation. A deepened understanding of the regulation of activation and inhibition of the T cell-based effector mechanisms has led to the development of drugs that are able to modify specific checkpoints of this system and thereby raise an immune response against tumor cells...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065420/cellular-immunotherapy-in-b-cell-malignancy
#18
Mark-Alexander Schwarzbich, Mathias Witzens-Harig
In recent years, cellular immunotherapy in B-cell malignancies has been driven by adoptive transfer of genetically engineered T cells expressing chimeric antigen receptors (CARs). CARs consist of a single chain variable fragment (scFv) of a monoclonal antibody, a spacer domain, a transmembrane domain, an intracellular signaling domain, and additional costimulatory domains. The bulk of clinical data available is on CD19-targeting CAR T cells for the treatment of B-cell acute lymphocytic leukemia (B-ALL), chronic lymphocytic leukemia, and B-cell non-Hodgkin lymphoma...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065415/evidence-for-an-association-of-ercc1-expression-and-mismatch-repair-status-with-overall-survival-in-colorectal-cancer-patients
#19
Pan Li, Zhi-Tao Xiao, Todd A Braciak, Qing-Jian Ou, Gong Chen, Fuat S Oduncu
BACKGROUND: The aim in this study was to determine if an association of excision repair cross-complementing group 1 (ERCC1) gene and mismatch repair (MMR) status with overall survival (OS) could be found from our analysis of a large cohort of Chinese colorectal cancer patients (CRC). METHODS: In total, 2,233 tissue samples isolated from individual CRC tumors were assessed by immunohistochemistry for the expression of ERCC1 and 4 MMR genes. RESULTS: The rates of proficient MMR (pMMR) and ERCC1 expression were 89...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065412/circulating-cell-free-dna-levels-in-patients-with-metastatic-renal-cell-carcinoma
#20
Keren Rouvinov, Wilmosh Mermershtain, Hadas Dresler, Samuel Ariad, Reut Riff, Noa Shani-Shrem, Daniel Keizman, Amos Douvdevani
BACKGROUND: Limited data about biomarkers are available to predict the outcomes of targeted therapy in metastatic renal cell carcinoma (mRCC). Circulating cell-free DNA (CFD) is elevated in various cancers. PATIENTS AND METHODS: We performed a prospective study of patients with mRCC who received targeted therapy in the Soroka Medical Center between 2013 and 2015. CFD levels were measured using a simple fluorometric assay. Blood samples for CFD were collected before treatment and at weeks 1, 4, 12, 18, and 24 of treatment...
2017: Oncology Research and Treatment
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