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Oncology Research and Treatment

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https://www.readbyqxmd.com/read/29151110/family-oriented-rehabilitation-for-and-rehabilitation-of-adolescents-and-young-adults-aya-in-pediatric-oncology
#1
Konstantin A Krauth
No abstract text is available yet for this article.
November 20, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29080889/meetings-and-conferences
#2
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29080888/society-bulletins
#3
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29069663/specific-adoptive-cellular-immunotherapy-in-allogeneic-stem-cell-transplantation
#4
Stefan Audehm, Angela M Krackhardt
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents a treatment option for a diversity of advanced hematopoietic malignancies providing hope for long-term responses especially due to immunogenic effects associated with the treatment modality. Despite respectable progress in the field, relapses and/or opportunistic infections are major reasons for the high treatment-related mortality. However, a number of novel immunotherapeutic approaches using defined cell populations have been developed to directly target residual malignant cells as well as defined infectious diseases...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065424/checkpoint-inhibition-in-hodgkin-lymphoma-a-review
#5
Paul J Bröckelmann, Andreas Engert
Physiological immune checkpoint pathways are important to regulate self-tolerance, limit immune reactions, and moderate autoimmunity. Various cancers are commonly exploiting these mechanisms to evade the host immune system by restraining a durable, efficient anti-tumor immune response. Immune checkpoints include, but are not limited to, the programmed death 1 (PD1) and the cytotoxic T-lymphocyte-associated protein-4 (CTLA4) axis, which are both druggable by monoclonal antibodies referred to as checkpoint inhibitors (CIs)...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065421/checkpoint-inhibition-in-non-hodgkin-s-lymphoma
#6
Georg Heß
As patients continue to die from malignant lymphoma, novel treatment options continue to be warranted. To successfully grow and spread, tumor cells need to escape the immune system; therefore, the augmentation or restoration of immune effectors against the malignant cell could be of great value, as shown, e.g., for allogeneic transplantation. A deepened understanding of the regulation of activation and inhibition of the T cell-based effector mechanisms has led to the development of drugs that are able to modify specific checkpoints of this system and thereby raise an immune response against tumor cells...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065420/cellular-immunotherapy-in-b-cell-malignancy
#7
Mark-Alexander Schwarzbich, Mathias Witzens-Harig
In recent years, cellular immunotherapy in B-cell malignancies has been driven by adoptive transfer of genetically engineered T cells expressing chimeric antigen receptors (CARs). CARs consist of a single chain variable fragment (scFv) of a monoclonal antibody, a spacer domain, a transmembrane domain, an intracellular signaling domain, and additional costimulatory domains. The bulk of clinical data available is on CD19-targeting CAR T cells for the treatment of B-cell acute lymphocytic leukemia (B-ALL), chronic lymphocytic leukemia, and B-cell non-Hodgkin lymphoma...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065415/evidence-for-an-association-of-ercc1-expression-and-mismatch-repair-status-with-overall-survival-in-colorectal-cancer-patients
#8
Pan Li, Zhi-Tao Xiao, Todd A Braciak, Qing-Jian Ou, Gong Chen, Fuat S Oduncu
BACKGROUND: The aim in this study was to determine if an association of excision repair cross-complementing group 1 (ERCC1) gene and mismatch repair (MMR) status with overall survival (OS) could be found from our analysis of a large cohort of Chinese colorectal cancer patients (CRC). METHODS: In total, 2,233 tissue samples isolated from individual CRC tumors were assessed by immunohistochemistry for the expression of ERCC1 and 4 MMR genes. RESULTS: The rates of proficient MMR (pMMR) and ERCC1 expression were 89...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065412/circulating-cell-free-dna-levels-in-patients-with-metastatic-renal-cell-carcinoma
#9
Keren Rouvinov, Wilmosh Mermershtain, Hadas Dresler, Samuel Ariad, Reut Riff, Noa Shani-Shrem, Daniel Keizman, Amos Douvdevani
BACKGROUND: Limited data about biomarkers are available to predict the outcomes of targeted therapy in metastatic renal cell carcinoma (mRCC). Circulating cell-free DNA (CFD) is elevated in various cancers. PATIENTS AND METHODS: We performed a prospective study of patients with mRCC who received targeted therapy in the Soroka Medical Center between 2013 and 2015. CFD levels were measured using a simple fluorometric assay. Blood samples for CFD were collected before treatment and at weeks 1, 4, 12, 18, and 24 of treatment...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065399/definitive-radiotherapy-for-primary-squamous-cell-carcinoma-of-the-vagina-are-high-dose-external-beam-radiotherapy-and-high-dose-rate-brachytherapy-boost-the-best-treatment-experience-of-two-italian-institutes
#10
Concetta Laliscia, Angiolo Gadducci, Maria G Fabrini, Amelia Barcellini, Maria E Guerrieri, Emanuela Parietti, Stefano Ursino, Riccardo Morganti, Ines Cafaro, Fabiola Paiar
INTRODUCTION: We assessed the clinical outcome and survival of 70 patients with primary vaginal squamous cell carcinoma undergoing radiotherapy (RT) at the Divisions of Radiotherapy, University of Pisa and ASST Cremona between January 1995 and June 2016. METHODS: 58 patients received external beam RT (EBRT) to the entire vagina, para-vaginal area and pelvic nodes (total dose: 45-50.4 Gy). 29 patients (41.4%) received concomitant weekly cisplatin 40 mg/m2. 35 patients received an additional (15-36 Gy) high-dose-rate (HDR) brachytherapy (BT) boost and 13 received an additional (9-25 Gy) EBRT boost to the primary tumor site...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29065397/immune-therapy-of-lympho-hemopoietic-malignancies
#11
Hakim Echchannaoui, Matthias Theobald
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29041012/wilms-tumor-gene-1-wt1-peptide-vaccine-therapy-for-hematological-malignancies-from-ctl-epitope-identification-to-recent-progress-in-clinical-studies-including-a-cure-oriented-strategy
#12
Yoshihiro Oka, Akihiro Tsuboi, Jun Nakata, Sumiyuki Nishida, Naoki Hosen, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama
The identification of human Wilms' tumor gene 1 (WT1) protein-derived cytotoxic T lymphocyte (CTL) epitopes and the in vivo efficacy of WT1 peptide-based immunotherapy in a mouse model were reported in 2000. This successful basic research led to clinical studies of a WT1 peptide vaccine, and a positive impact on clinical response was first demonstrated in 2003 in the form of a reduction in blast cells of vaccine-treated patients with myelodysplastic syndromes (MDS). Since then, data on WT1 peptide vaccine-treated patients with immunological and/or clinical response have been accumulated...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28982097/erratum
#13
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28950283/clinicopathological-significance-of-s100a14-expression-in-lung-adenocarcinoma
#14
Ken Katono, Yuichi Sato, Makoto Kobayashi, Keita Saito, Ryo Nagashio, Shinichiro Ryuge, Satoshi Igawa, Hiroyasu Nakashima, Kazu Shiomi, Yukitoshi Satoh, Masaaki Ichinoe, Yoshiki Murakumo, Makoto Saegusa, Noriyuki Masuda
BACKGROUND: Several studies have reported that S100A14 plays important roles during different steps of the tumorigenic process and tumor progression of several types of cancer. The aim of the present study was to investigate the clinicopathological and prognostic significance and functional roles of S100A14 in lung adenocarcinoma. PATIENTS AND METHODS: S100A14 expression was immunohistochemically studied in 166 consecutive resected lung adenocarcinomas, and its correlation with clinicopathological parameters was evaluated...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28950275/magnetic-resonance-features-and-characteristic-vascular-pattern-of-alveolar-soft-part-sarcoma
#15
Jiu-Fa Cui, Hai-Song Chen, Da-Peng Hao, Ji-Hua Liu, Feng Hou, Wen-Jian Xu
OBJECTIVE: The aim of this study was to investigate the magnetic resonance (MR) features of alveolar soft-part sarcoma (ASPS). METHODS: We studied 12 patients with ASPS confirmed by pathology in this retrospective study. MR features were analyzed, especially for the location, morphology, signals, and related enhanced features of the tumor vessels. RESULTS: Flow voids were shown in the central part of the tumor on T2-weighted imaging (T2WI) in all patients; they were arrayed in a radiating mode gathered toward the center (8 cases), designated by us as vascular center-gathered syndrome (VCGS), or scattered like twigs (4 cases)...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28950274/specific-characteristics-of-patients-with-advanced-genitourinary-cancer-receiving-specialized-inpatient-palliative-care
#16
Katharina Iversen, Karin Oechsle, Christoph Oing, Carsten Bokemeyer, Christoph Seidel
BACKGROUND: The aim of this study was to compare the characteristics for genitourinary cancer (GUC) patients receiving specialized inpatient palliative care (SIPC) with those of a general cohort. METHODS: We retrospectively evaluated 151 GUC patients receiving SIPC from 2008 to 2014 regarding symptoms, problems, treatment, and outcome. These characteristics were compared with a general cohort of 1,285 patients with various diseases who received SIPC (German Hospice and Palliative care investigation: HOPE)...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28950270/immune-thrombocytopenia-induced-by-nivolumab-in-a-metastatic-non-small-cell-lung-cancer-patient
#17
Yusuf Karakas, Deniz Yuce, Saadettin Kılıckap
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28950269/the-revised-international-staging-system-compared-to-the-classical-international-staging-system-better-discriminates-risk-groups-among-transplant-ineligible-multiple-myeloma-patients
#18
Jelena Bila, Jelena Jelicic, Marija Dencic Fekete, Goran Trajkovic, Aleksandra Sretenovic, Maja Perunicic Jovanovic, Darko Antic, Biljana Mihaljevic
BACKGROUND: The Revised International Staging System (R-ISS) has recently been introduced as a comprehensive prognostic score for multiple myeloma (MM). Validation of the R-ISS in patients treated outside of clinical trials is the focus of current investigations. The aim of this study was to test the prognostic role of the R-ISS in MM patients ineligible for autologous stem cell transplantation. PATIENTS AND METHODS: A total of 102 newly diagnosed MM patients were analyzed...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28946149/clinical-correlates-and-prognostic-significance-of-il-8-sil-2r-and-immunoglobulin-free-light-chain-levels-in-patients-with-myelofibrosis
#19
Maria V Barabanshikova, Irina A Dubina, Sergey V Lapin, Elena V Morozova, Julia J Vlasova, Maria O Ivanova, Ivan S Moiseev, Boris V Afanasyev
BACKGROUND: Chronic myeloproliferative neoplasms are characterized by clonal hematopoiesis and persistent inflammatory reaction. In this study, the clinical significance and prognostic impact of several inflammatory markers were evaluated in patients with BCR/ABL-negative myeloproliferative malignancies. METHODS: Serum levels of interleukin-8 (IL-8) and lymphoid-associated activation markers - soluble interleukin-2 receptor (sIL-2R) and immunoglobulin-free light chains (FLC) - were evaluated in patients with primary myelofibrosis (MF), post-polycythemia vera MF, and post-essential thrombocythemia MF, and compared with the levels in healthy donors...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28934740/jahrestagung-der-deutschen-%C3%A3-sterreichischen-und-schweizerischen-gesellschaften-f%C3%A3-r-h%C3%A3-matologie-und-medizinische-onkologie-stuttgart-29-september-3-oktober-2017-abstracts
#20
(no author information available yet)
No abstract text is available yet for this article.
2017: Oncology Research and Treatment
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