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Brain Tumor Research and Treatment

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https://www.readbyqxmd.com/read/27867931/seeding-of-meningeal-sarcoma-along-a-surgical-trajectory-on-the-scalp
#1
Lho Hyoung Woo, Yoon Wan Soo, Chung Dong Sup
Primary sarcomas of the central nervous system are rare. These tumors is rapid growth often produces mass effect on the brain. Diagnosis is rendered pathologically after resection. Surgical resection is the mainstay treatment and need the adjuvant therapy. We report a 44-year-old female with a meningeal sarcoma of frontal meninges. She complained headache for 2 months and palpable forehead mass for 3 weeks. Brain MRI demonstrated a soft tissue mass sized as 5.3×3.7×3.1 cm with well-defined osteolysis on the midline of the frontal bone...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867930/a-case-of-primary-central-nervous-system-lymphoma-located-at-brain-stem-in-a-child
#2
Jinho Kim, Young Zoon Kim
Primary central nervous system lymphoma (PCNSL) is an extranodal Non-Hodgkin's lymphoma that is confined to the brain, eyes, and/or leptomeninges without evidence of a systemic primary tumor. Although the tumor can affect all age groups, it is rare in childhood; thus, its incidence and prognosis in children have not been well defined and the best treatment strategy remains unclear. A nine-year old presented at our department with complaints of diplopia, dizziness, dysarthria, and right side hemiparesis. Magnetic resonance image suggested a diffuse brain stem glioma with infiltration into the right cerebellar peduncle...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867929/comparison-of-3-and-7-tesla-magnetic-resonance-imaging-of-obstructive-hydrocephalus-caused-by-tectal-glioma
#3
Hyeong Cheol Moon, Hyeon-Man Baek, Young Seok Park
Obstructive hydrocephalus caused by tectal glioma, which relived by neuroendoscopy, have been described using 3.0 Tesla magnetic resonance imaging (3T MRI) so far, we present the results obtained from 3T and 7T MRI in this patient. A 21-year-old woman presented at our hospital with gait disturbance, hormonal insufficiency, and urinary incontinence that began prior to 6 years of age. 3.0T MRI revealed a non-enhancing tectal mass along with obstructive hydrocephalus. The mass measured approximately 1.1×1.0×1...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867928/world-health-organization-grade-ii-oligodendroglioma-occurring-after-successful-treatment-for-childhood-acute-lymphoblastic-leukemia
#4
Sang-In Yoon, Kyung-Jae Park, Dong-Hyuk Park, Shin-Hyuk Kang, Jung-Yul Park, Yong-Gu Chung
When treating childhood acute lymphoblastic leukemia (ALL), secondary neoplasms are a significant long term problem. Radiation is generally accepted to be a major cause of the development of secondary neoplasms. Following treatment for ALL, a variety of secondary tumors, including brain tumors, hematologic malignancies, sarcomas, thyroid cancers, and skin cancers have been reported. However, oligodendroglioma as a secondary neoplasm is extremely rare. Herein we present a case of secondary oligodendroglioma occurring 13 years after the end of ALL treatment...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867927/multiple-meningocerebral-metastasis-and-extensive-skull-metastasis-from-squamous-cell-carcinoma-of-esophagus-a-case-report-and-review-of-literature
#5
Min Kyun Na, Choong Hyun Kim, Jae Min Kim, Jin Whan Cheong, Je Il Ryu, Hyun Woo Kim
Esophageal carcinoma rarely metastasizes to the brain. Although some studies have mentioned esophageal cancer with solitary brain metastasis or with meningocerebral metastasis or with skull metastasis, multiple meningocerebral metastasis and extensive skull metastasis from squamous cell carcinoma of esophagus has not been reported in the literature. We encountered a case of an extensive osteolytic change of the skull and multiple meningocerebral metastases from esophageal carcinoma.
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867926/a-case-of-solitary-brain-metastasis-from-uterine-mullerian-adenosarcoma-with-sarcomatous-overgrowth
#6
Suk Bo Hong, Min Jung Kim, Ji Yeon Kwon, Seok Jin Choi, Eun Young Kim, Joohan Lim
Uterine adenosarcoma (AS) are rare tumors and have more favorable outcomes than the aggressive uterine carcinosarcomas. Uterine adenosarcoma with sarcomatous overgrowth (ASSO) is a variant form of AS and exhibits aggressive growth of tumor and the prognosis is relatively poor compared with typical AS. Usually patterns of metastasis have been known to behave like endometrial carcinoma and spread through the lymphatics. Brain metastasis from uterine AS is extremely rare. Herein, we report a case of successfully surgically removed solitary brain metastasis without any extracranial recurrence from uterine ASSO after 4 years of primary treatment...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867925/a-stable-secondary-gliosarcoma-with-extensive-systemic-metastases-a-case-report
#7
Tae-Min Choi, Young-Jun Cheon, Tae-Young Jung, Kyung-Hwa Lee
A 63-year-old man complained of intermittent motor weakness of his arm. The magnetic resonance image (MRI) of his brain displayed a high signal lesion in right cingulate gyrus on T2 weighted image. One year later, he showed a stuporous mental status with repeated seizures, and the follow-up brain MRI showed heterogeneously enhanced mass associated with bleeding. He was treated with surgery and radiotherapy for secondary glioblastomas in right cingulate gyrus. One year more later, a mass recurred on the left frontal base, and gliosarcoma was diagnosed...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867924/metastatic-intracranial-hemangiopericytoma-to-the-spinal-column-a-case-report
#8
Myung Sung Joo, Young Joon Rho, Sang Woo Song, Young-Cho Koh, Hong Gee Roh, So-Dug Lim
Intracranial hemangiopericytoma (HPC) is a rare brain tumor with aggressive biologic behavior associated with high recurrence rate and often with extracranial metastasis. The most common sites of extracranial metastasis of the intracranial HPC are the long bones, lung, liver and abdominal cavity in the order of frequencies. Extracranial metastases usually occur long after the initial diagnosis of the primary tumor. Metastatic intracranial HPC to the vertebra has been rarely reported. We present a case of intracranial HPC metastasized to the L2 vertebral body 13 years after multiple surgical resections and radiotherapy of the primary intracranial HPC...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867923/failed-first-craniotomy-and-tumor-removal-of-parasagittal-meningioma-with-severe-peritumoral-brain-edema
#9
Youngbo Shim, Sang Hyung Lee
Parasagittal meningioma often presents as peritumoral brain edema (PTBE). The risk of edema increases when the tumor occludes the superior sagittal sinus (SSS). Although PTBE may be expected based on the patient's symptoms or radiologic findings, extensive brain swelling and extracranial herniation during elective surgery are rare. Herniation during surgery could lead to irreversible neurological damage and even brain rupture. We report a case of a failed routine craniotomy for a parasagittal meningioma with complete occlusion of the posterior third of the SSS in a 30-year-old male patient...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867922/palliative-resection-of-metastatic-brain-tumors-previously-treated-by-stereotactic-radiosurgery
#10
Yoo Sung Jeon, Young-Cho Koh, Sang Woo Song, Joon Cho, So Dug Lim
BACKGROUND: Therapeutic approaches to brain metastases include surgery, whole-brain radiotherapy, stereotactic radiosurgery (SRS), and combination therapy. Recently, postoperative or preoperative SRS draws more attention to reduce postoperative recurrence in brain metastases. The goal of this study is to review surgical outcome of patients who had been treated by SRS, and to discuss the effectiveness of preoperative SRS. METHODS: From 2009 to 2015, 174 patients were treated by SRS for brain metastases, and among these 50 patients underwent surgery...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867921/neurological-change-after-gamma-knife-radiosurgery-for-brain-metastases-involving-the-motor-cortex
#11
Chang-Yong Park, Hyun-Yong Choi, Sang-Ryul Lee, Tae Hoon Roh, Mi-Ra Seo, Se-Hyuk Kim
BACKGROUND: Although Gamma Knife radiosurgery (GKRS) can provide beneficial therapeutic effects for patients with brain metastases, lesions involving the eloquent areas carry a higher risk of neurologic deterioration after treatment, compared to those located in the non-eloquent areas. We aimed to investigate neurological change of the patients with brain metastases involving the motor cortex (MC) and the relevant factors related to neurological deterioration after GKRS. METHODS: We retrospectively reviewed clinical, radiological and dosimetry data of 51 patients who underwent GKRS for 60 brain metastases involving the MC...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867920/optimal-treatment-decision-for-brain-metastases-of-unknown-primary-origin-the-role-and-timing-of-radiosurgery
#12
Hyun Jin Han, Won Seok Chang, Hyun Ho Jung, Yong Gou Park, Hae Yu Kim, Jong Hee Chang
BACKGROUND: Up to 15% of all patients with brain metastases have no clearly detected primary site despite intensive evaluation, and this incidence has decreased with the use of improved imaging technology. Radiosurgery has been evaluated as one of the treatment modality for patients with limited brain metastases. In this study, we evaluated the effectiveness of radiosurgery for brain metastases from unknown primary tumors. METHODS: We retrospectively evaluated 540 patients who underwent gamma knife radiosurgery (GKRS) for brain metastases radiologically diagnosed between August 1992 and September 2007 in our institution...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867919/white-matter-change-revealed-by-diffusion-tensor-imaging-in-gliomas
#13
Young Il Won, Chun Kee Chung, Chi Heon Kim, Chul-Kee Park, Bang-Bon Koo, Jong-Min Lee, Hee-Won Jung
BACKGROUND: Tumor-related white matter change is detected at late stages with magnetic resonance imaging (MRI), when mass effect or prominent edema is present. We analyzed if diffusion tensor imaging (DTI) white matter change earlier than conventional MRI. METHODS: Twenty-six patients with gliomas (World Health Organization grade II, 5; grade III, 12; and grade IV, 9) within 2 cm from the posterior limb of the internal capsule (IC) were studied. Fifteen normal adults were enrolled as controls...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867918/clinical-and-radiological-characteristics-of-angiomatous-meningiomas
#14
Juyoung Hwang, Doo-Sik Kong, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee, Jung Won Choi
BACKGROUND: Angiomatous meningioma is a rare histological subtype of meningioma. Therefore, this specific medical condition is rarely reviewed in the literature. In the present work, we report the clinical and radiological features with postoperative outcomes of angiomatous meningioma. METHODS: This retrospective study included the patients who were pathologically diagnosed with angiomatous meningioma after surgical resection between February 2010 and September 2015 in our institute...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867917/health-related-quality-of-life-in-brain-tumor-patients-treated-with-surgery-preliminary-result-of-a-single-institution
#15
Chang-Wook Kim, Jin-Deok Joo, Young-Hoon Kim, Jung Ho Han, Chae-Yong Kim
BACKGROUND: Alongside the extent of removal and patients' survival in the management of brain tumors, health-related quality of life (HRQOL) has become an important consideration. The purpose of this study is to evaluate the change of HRQOL in brain tumor patients before and after surgery and to assess the associated factors that contribute to the change of HRQOL. METHODS: A total of 258 patients who underwent surgical treatment were enrolled in this study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and the 20-item EORTC QLQ-Brain Neoplasm (QLQ-BN20) were used to assess HRQOL...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867916/impact-of-human-immunodeficiency-virus-in-the-pathogenesis-and-outcome-of-patients-with-glioblastoma-multiforme
#16
Winward Choy, Carlito Lagman, Seung J Lee, Timothy T Bui, Michael Safaee, Isaac Yang
BACKGROUND: Improvement in antiviral therapies have been accompanied by an increased frequency of non-Acquired Immune Deficiency Syndrome (AIDS) defining malignancies, such as glioblastoma multiforme. Here, we investigated all reported cases of human immunodeficiency virus (HIV)-positive patients with glioblastoma and evaluated their clinical outcomes. A comprehensive review of the molecular pathogenetic mechanisms underlying glioblastoma development in the setting of HIV/AIDS is provided...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867915/surgical-resection-of-non-glial-tumors-in-the-motor-cortex
#17
Seong-Jong Lee, Sun-Chul Hwang, Soo Bin Im, Bum-Tae Kim
BACKGROUND: Direct surgery to resect tumors in the motor cortex could improve neurological symptoms or cause novel motor weakness. The present study describes the neurological outcomes of patients after the surgical resection of non-glial tumors in the primary motor cortex. METHODS: The present study included 25 patients who had pathologically confirmed non-glial tumors in the motor cortex for which they underwent surgery. Tumor location was verified using anatomical landmarks on preoperative magnetic resonance imaging scans...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867914/therapeutic-strategy-for-cavernous-sinus-invading-non-functioning-pituitary-adenomas-based-on-the-modified-knosp-grading-system
#18
Juyoung Hwang, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee, Min Ho Lee, Doo-Sik Kong
BACKGROUND: Non-functioning pituitary adenomas (NFPA) invading into the cavernous sinus are surgically challenging. To decrease recurrence rate, surgeon makes a strong endeavor to resect tumor gross totally. However, gross total resection (GTR) is difficult to achieve with cavernous sinus invasion. Recently, a new classification system for cavernous invasion of pituitary adenomas was suggested. The aim of this study is to validate this new classification system and to identify limitations and considerations in designing treatment strategies for patients with NFPA involving the cavernous sinus...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867913/spontaneous-involution-of-rathke-s-cleft-cysts-without-visual-symptoms
#19
Chang-Wook Kim, Kihwan Hwang, Jin-Deok Joo, Young-Hoon Kim, Jung Ho Han, Chae-Yong Kim
BACKGROUND: There have been various reports in the literature regarding the conservative management of pituitary apoplexy, pituitary incidentalomas and Rathke cleft cysts (RCCs). However, to the best of our knowledge, spontaneous involution of cystic sellar mass has rarely been reported. We report 14 cases of cystic sellar masses with spontaneous involution. METHODS: A total of 14 patients with spontaneous regression of cystic sellar masses in our hospital were included...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867912/central-neurocytoma-a-review-of-clinical-management-and-histopathologic-features
#20
REVIEW
Seung J Lee, Timothy T Bui, Cheng Hao Jacky Chen, Carlito Lagman, Lawrance K Chung, Sabrin Sidhu, David J Seo, William H Yong, Todd L Siegal, Minsu Kim, Isaac Yang
Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to improve tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy...
October 2016: Brain Tumor Research and Treatment
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