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Journal of Immunology Research

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https://www.readbyqxmd.com/read/30327786/silicone-induced-granuloma-of-breast-implant-capsule-sigbic-histopathology-and-radiological-correlation
#1
REVIEW
Eduardo de Faria Castro Fleury, Gabriel Salum D'Alessandro, Sheila Cristina Lordelo Wludarski
Currently, attention has been given to complications related to breast implants, especially due to the presence of anaplastic large cell lymphoma (ALCL) related to silicone implants. Many manuscripts attempt to associate silicone presence with clinical complaints reported by patients, while others try to demonstrate the mechanisms of silicone bleeding by permeability loss of breast implant surfaces. There also are reports of foreign body type reactions from implant fibrous capsule to silicone corpuscles. However, there seems to be no study that correlates the clinical, radiological, and histological correlations of these lesions...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30320140/beneficial-effects-of-poplar-buds-on-hyperglycemia-dyslipidemia-oxidative-stress-and-inflammation-in-streptozotocin-induced-type-2-diabetes
#2
Shiqin Peng, Ping Wei, Qun Lu, Rui Liu, Yue Ding, Jiuliang Zhang
The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insulin resistance, as well as decrease the levels of fasting blood glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30306094/evaluation-of-soluble-cd48-levels-in-patients-with-allergic-and-nonallergic-asthma-in-relation-to-markers-of-type-2-and-non-type-2-immunity-an-observational-study
#3
Oded Breuer, Roopesh Singh Gangwar, Mansour Seaf, Ahlam Barhoum, Eitan Kerem, Francesca Levi-Schaffer
CD48 is a costimulatory receptor associated with human asthma. We aimed to assess the significance of the soluble form of CD48 (sCD48) in allergic and nonallergic asthma. Volunteer patients completed an asthma and allergy questionnaire, spirometry, methacholine challenge test, a common allergen skin prick test, and a complete blood count. sCD48, IgE, IL5, IL17A, IL33, and IFN γ were quantitated in serum by ELISA. Asthma was defined as positive methacholine challenge test or a 15% increase in FEV1 post bronchodilator in symptomatic individuals...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30306093/viral-and-nonviral-engineering-of-natural-killer-cells-as-emerging-adoptive-cancer-immunotherapies
#4
REVIEW
Sandro Matosevic
Natural killer (NK) cells are powerful immune effectors whose antitumor activity is regulated through a sophisticated network of activating and inhibitory receptors. As effectors of cancer immunotherapy, NK cells are attractive as they do not attack healthy self-tissues nor do they induce T cell-driven inflammatory cytokine storm, enabling their use as allogeneic adoptive cellular therapies. Clinical responses to adoptive NK-based immunotherapy have been thwarted, however, by the profound immunosuppression induced by the tumor microenvironment, particularly severe in the context of solid tumors...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30302345/carbamazepine-mediated-adverse-drug-reactions-cbz-10-11-epoxide-but-not-carbamazepine-induces-the-alteration-of-peptides-presented-by-hla-b%C3%A2-15-02
#5
Gwendolin S Simper, Gia-Gia T Hò, Alexander A Celik, Trevor Huyton, Joachim Kuhn, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding
Among patients treated with the anticonvulsive and psychotropic drug carbamazepine (CBZ), approximately 10% develop severe and life-threatening adverse drug reactions. These immunological conditions are resolved upon withdrawal of the medicament, suggesting that the drug does not manifest in the body in long term. The HLA allele B∗15:02 has been described to be a genomic biomarker for CBZ-mediated immune reactions. It is not well understood if the immune reactions are triggered by the original drug or by its metabolite carbamazepine-10,11-epoxide (EPX) and how the interaction between the drug and the distinct HLA molecule occurs...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30302344/cancer-immunotherapy-priming-the-host-immune-response-with-live-attenuated-salmonella-enterica
#6
REVIEW
Marco Antonio Hernández-Luna, Rosendo Luria-Pérez
In recent years, cancer immunotherapy has undergone great advances because of our understanding of the immune response and the mechanisms through which tumor cells evade it. A century after the first immunotherapy attempt based on bacterial products described by William Coley, the use of live attenuated bacterial vectors has become a promising alternative in the fight against cancer. This review describes the role of live attenuated Salmonella enterica as an oncolytic and immunotherapeutic agent, due to its high affinity for tumor tissue and its ability to activate innate and adaptive antitumor immune response...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30298138/inflammatory-driven-angiogenesis-in-bone-augmentation-with-bovine-hydroxyapatite-b-tricalcium-phosphate-and-bioglasses-a-comparative-study
#7
Vlad M Anghelescu, Ioana Neculae, Octavian Dincă, Cristian Vlădan, Claudiu Socoliuc, Mirela Cioplea, Luciana Nichita, Cristiana Popp, Sabina Zurac, Alexandru Bucur
Introduction: The clinical use of bioactive materials for bone augmentation has remained a challenge because of predictability and effectiveness concerns, as well as increased costs. The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30276219/serum-and-ectopic-endometrium-from-women-with-endometriosis-modulate-macrophage-m1-m2-polarization-via-the-smad2-smad3-pathway
#8
Mei-Fang Nie, Qi Xie, Ya-Hong Wu, Hua He, Lu-Jie Zou, Xiao-Ling She, Xian-Qing Wu
Objective: This study investigated the alterations in macrophage polarization in patients with endometriosis as well as the underlying molecular mechanisms. Methods: Peritoneal washings, serum samples, and endometrial tissues were collected from endometriosis patients and control subjects. Endometrial stromal cells (ESCs) were isolated from endometrial tissue, and conditioned medium was prepared by treating ESCs with or without various concentrations of interleukin- (IL-) 6, estrogen, or progestin...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30276218/osu-t315-as-an-interesting-lead-molecule-for-novel-b-cell-specific-therapeutics
#9
Kristien Van Belle, Jean Herman, Mark Waer, Ben Sprangers, Thierry Louat
B cells are pathogenic in various disease processes and therefore represent an interesting target for the development of novel immunosuppressants. In the search for new therapeutic molecules, we utilized an in vitro B cell activation assay with ODN2006-stimulated Namalwa cells to screen a chemical library of small molecules for B cell modulating effects. OSU-T315, described as an inhibitor of integrin-linked kinase (ILK), was hereby identified as a hit. On human and murine primary B cells, OSU-T315 potently suppressed the proliferation and the production of antibodies and cytokines upon stimulation, suggesting that ILK could be a promising target in the modulation of B cell activity...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30271793/differences-of-clonogenic-mesenchymal-stem-cells-on-immunomodulation-of-lymphocyte-subsets
#10
Pascual Martínez-Peinado, Sandra Pascual-García, Enrique Roche, José Miguel Sempere-Ortells
Mesenchymal stem cells (MSC) are a widely used population in cell therapy for their ability to differentiate into distinct tissues and more lately, for their immunomodulatory properties. However, the use of heterogeneous populations could be responsible for the nondesired outcomes reflected in the literature. Here, we analyse the different capacities of five one-cell-derived MSC clones to exert their immunomodulation ex vivo. We assessed proliferation assays in cocultures of MSC clones and purified cluster of differentiation (CD)3+ , CD4+ , or CD8+ lymphocytes; analysed the regulatory T (Treg) cells fold change rate; determined the effects on viability of peripheral blood mononuclear cells (PBMC); and also measured the coculture cytokine profiles (Th1/Th2)...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30271792/inflammation-related-mechanisms-in-chronic-kidney-disease-prediction-progression-and-outcome
#11
REVIEW
Simona Mihai, Elena Codrici, Ionela Daniela Popescu, Ana-Maria Enciu, Lucian Albulescu, Laura Georgiana Necula, Cristina Mambet, Gabriela Anton, Cristiana Tanase
Persistent, low-grade inflammation is now considered a hallmark feature of chronic kidney disease (CKD), being involved in the development of all-cause mortality of these patients. Although substantial improvements have been made in clinical care, CKD remains a major public health burden, affecting 10-15% of the population, and its prevalence is constantly growing. Due to its insidious nature, CKD is rarely diagnosed in early stages, and once developed, its progression is unfortunately irreversible. There are many factors that contribute to the setting of the inflammatory status in CKD, including increased production of proinflammatory cytokines, oxidative stress and acidosis, chronic and recurrent infections, altered metabolism of adipose tissue, and last but not least, gut microbiota dysbiosis, an underestimated source of microinflammation...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30255108/immune-and-inflammatory-mediated-disorders-from-bench-to-bedside
#12
EDITORIAL
Marcella Reale, Lucia Conti, Diana Velluto
No abstract text is available yet for this article.
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30255107/the-proportion-of-regulatory-t-cells-in-patients-with-systemic-lupus-erythematosus-a-meta-analysis
#13
REVIEW
Sheng-Xiao Zhang, Xiao-Wen Ma, Yu-Feng Li, Na-Ling Lai, Ze-Hao Huang, Kai Fan, Cai-Hong Wang, Xiao-Feng Li
Background: Accumulating evidence indicates that a deficiency in or dysfunction of regulatory T cells (Tregs) is involved in the pathogenesis of systemic lupus erythematosus (SLE). As different markers have been used to identify Tregs, recent studies on the proportions of Tregs in SLE patients have generated controversial results. To clarify the status of Tregs in such patients, we determined the proportions of Tregs present during development of the disease, with special consideration of controversial cellular markers...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30255106/altered-nkp30-nkp46-nkg2d-and-dnam-1-expression-on-circulating-nk-cells-is-associated-with-tumor-progression-in-human-gastric-cancer
#14
Bin Han, Fang-Yuan Mao, Yong-Liang Zhao, Yi-Pin Lv, Yong-Sheng Teng, Mubing Duan, Weisan Chen, Ping Cheng, Ting-Ting Wang, Zhong-Yuan Liang, Jin-Yu Zhang, Yu-Gang Liu, Gang Guo, Quan-Ming Zou, Yuan Zhuang, Liu-Sheng Peng
Natural killer (NK) cell activity is influenced by a complex integration of signaling pathways activated downstream of both activating and inhibitory surface receptors. The tumor microenvironment can suppress NK cell activity, and there is a great clinical interest in understanding whether modulating tumor-mediated NK cell suppression and/or boosting preexisting NK cell numbers in cancer patients is therapeutically viable. To this light, we characterized the surface receptor phenotypes of peripheral blood NK cells and examined their clinical relevance to human gastric cancer (GC)...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30255105/the-role-of-autoimmune-regulator-aire-in-peripheral-tolerance
#15
REVIEW
Bingjie Zhao, Lu Chang, Haiying Fu, Guangyu Sun, Wei Yang
Autoimmune regulator (AIRE), whose gene mutation is considered to be a causative factor of autoimmune polyglandular syndrome type 1 (APS1), is an important transcriptional regulator. Studies on the role of AIRE in the central immune system have demonstrated that AIRE can eliminate autoreactive T cells by regulating the expression of a series of tissue specific antigens promiscuously in medullary thymic epithelial cells (mTECs) and induce regulatory T cell (Treg) production to maintain central immune tolerance...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30255104/fetal-and-maternal-outcomes-of-planned-pregnancy-in-patients-with-systemic-lupus-erythematosus-a-retrospective-multicenter-study
#16
Dongying Chen, Minxi Lao, Jianyu Zhang, Yanfeng Zhan, Weinian Li, Xiaoyan Cai, Zhongping Zhan
Objective: To investigate the fetal and maternal outcomes as well as predictors of APOs in women with SLE who conceived when the disease was stable, the so-called "planned pregnancy." Methods . A retrospective multicenter study of 243 patients with SLE who underwent a planned pregnancy was performed. APOs in fetus and mothers were recorded. Results: The average age at conception was 28.9 ± 3.9 years. Duration of SLE prior to pregnancy was 4.4 ± 4...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30255103/natural-killer-cells-in-liver-disease-and-hepatocellular-carcinoma-and-the-nk-cell-based-immunotherapy
#17
REVIEW
Pingyi Liu, Lingling Chen, Haiyan Zhang
Nature killer (NK) cells play a critical role in host innate and adaptive immune defense against viral infections and tumors. NK cells are enriched in liver hematopoietic cells with unique NK repertories and functions to safeguard liver cells against hepatitis virus infection or malignancy transformation. However, accumulating evidences were found that the NK cells were modulated by liver diseases and liver cancers including hepatocellular carcinoma (HCC) and showed impaired functions failing to activate the elimination of the viral-infected cells or tumor cells and were further involved in the pathogenesis of liver injury and inflammation...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30246036/tlr3-modulates-the-response-of-nk-cells-against-schistosoma-japonicum
#18
Jiale Qu, Lu Li, Hongyan Xie, Xiaona Zhang, Quan Yang, Huaina Qiu, Yuanfa Feng, Chenxi Jin, Nuo Dong, Jun Huang
Natural killer (NK) cells are classic innate immune cells that play roles in many types of infectious diseases. NK cells possess many kinds of TLRs that allow them to sense and respond to invading pathogens. Our previous study found that NK cells could modulate the immune response induced by Schistosoma japonicum (S. japonicum) in C57BL/6 mice. In the present study, the role of TLRs in the progress of S. japonicum infection was investigated. Results showed that the expression of TLR3 on NK cells increased significantly after S...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30246035/immunomodulatory-effects-of-17-%C3%AE-estradiol-on-epithelial-cells-during-bacterial-infections
#19
REVIEW
Ivan Medina-Estrada, Nayeli Alva-Murillo, Joel E López-Meza, Alejandra Ochoa-Zarzosa
The innate immune system can function under hormonal control. 17 β -Estradiol (E2) is an important sexual hormone for the reproductive cycle of mammals, and it has immunomodulatory effects on epithelial cells, which are the first line of defense against incoming bacteria. E2 regulates various pathophysiological processes, including the response to infection in epithelial cells, and its effects involve the regulation of innate immune signaling pathways, which are mediated through estrogen receptors (ERs). E2 modulates the expression of inflammatory and antimicrobial elements such as cytokines and antimicrobial peptides...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30246034/luteolin-induces-apoptosis-and-autophagy-in-mouse-macrophage-ana-1-cells-via-the-bcl-2-pathway
#20
Yuexia Liao, Yang Xu, Mengyao Cao, Yuanyuan Huan, Lei Zhu, Ye Jiang, Weigan Shen, Guoqiang Zhu
Plants rich in luteolin have been used as Chinese traditional medicines for inflammatory diseases, hypertension, and cancer. However, little is known about the effect of luteolin on the apoptosis or autophagy of the macrophages. In this study, mouse macrophage ANA-1 cells were incubated with different concentrations of luteolin. The viability of the cells was determined by an MTT assay, apoptosis was determined by flow cytometric analysis, the level of cell autophagy was observed by confocal microscopy, and the expression levels of apoptotic or autophagic and antiapoptotic or antiautophagic proteins were detected by Western blot analysis...
2018: Journal of Immunology Research
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