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Journal of Immunology Research

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https://www.readbyqxmd.com/read/29038791/traditional-chinese-medicine-protects-against-cytokine-production-as-the-potential-immunosuppressive-agents-in-atherosclerosis
#1
REVIEW
Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu
Atherosclerosis is a chronic inflammatory disease caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a critical factor at all stages of atherosclerosis progression. Proinflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28951880/chinese-herbal-formula-modified-danggui-buxue-tang-attenuates-apoptosis-of-hematopoietic-stem-cells-in-immune-mediated-aplastic-anemia-mouse-model
#2
Jingwei Zhou, Xue Li, Peiying Deng, Yi Wei, Juan Liu, Meng Chen, Yamei Xu, Dongmei Zhang, Lingqun Zhu, Lixia Lou, Bin Dong, Qiushuo Jin, Limin Chai
A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragali and Radix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation of the balance between proliferation and apoptosis of hematopoietic stem cells (HSCs) due to the aberrant immune response in a mouse model of aplastic anemia (AA). Cyclosporine (CsA), an immunosuppressor, was used as the positive control...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28948174/intestinal-dysbiosis-and-rheumatoid-arthritis-a-link-between-gut-microbiota-and-the-pathogenesis-of-rheumatoid-arthritis
#3
REVIEW
Gabriel Horta-Baas, María Del Socorro Romero-Figueroa, Alvaro José Montiel-Jarquín, María Luisa Pizano-Zárate, Jaime García-Mena, Ninfa Ramírez-Durán
Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome's role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and this finding has commanded this study as a possible autoimmune process...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28929124/the-humoral-theory-of-transplantation
#4
EDITORIAL
Mepur H Ravindranath, Junchao Cai, Soldano Ferrone, Frans H J Claas, Senthamil R Selvan
No abstract text is available yet for this article.
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28929123/in-vitro-immunomodulatory-activity-of-a-transition-state-analog-inhibitor-of-human-purine-nucleoside-phosphorylase-in-cutaneous-leishmaniasis
#5
Natália Barbosa Carvalho, Fernanda Ventin de Oliveira Prates, Rafael de Castro da Silva, Mayra Elizabeth Ferreira Dourado, Camila Farias Amorim, Paulo Roberto Lima Machado, Fernanda Grendene Pacheco, Temis Weber Furlanetto Corte, Pablo Machado, Diógenes Santiago Santos, Edgar Marcelino de Carvalho
Cutaneous leishmaniasis (CL) is the most common clinical form of American tegumentary leishmaniasis caused by Leishmania (Viannia) braziliensis. CL is associated with a strong Th1 immune response. This exacerbated inflammatory response is correlated with severity of disease and delays the healing time of the ulcer. The fourth-generation immucillin derivative (DI4G), a potent inhibitor of purine nucleoside phosphorylase, has been proposed as a promising agent in the treatment of diseases associated with T cell activation...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28913368/erratum-to-low-baseline-interleukin-17a-levels-are-associated-with-better-treatment-response-at-12-weeks-to-tocilizumab-therapy-in-rheumatoid-arthritis-patients
#6
Sang Jin Lee, Won Park, Sung Hwan Park, Seung-Cheol Shim, Han Joo Baek, Dae-Hyun Yoo, Hyun Ah Kim, Soo Kon Lee, Yun Jong Lee, Young Eun Park, Hoon-Suk Cha, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Yeong Wook Song
[This corrects the article DOI: 10.1155/2015/487230.].
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28913367/efficacy-of-tumor-infiltrating-lymphocytes-combined-with-ifn-%C3%AE-in-chinese-resected-stage-iii-malignant-melanoma
#7
Wei Li, Linping Xu, Yaomei Wang, Lingdi Zhao, Daniel B Kellner, Quanli Gao
BACKGROUND: This study aims to explore the efficacy of tumor-infiltrating lymphocytes (TIL) along with interferon-α (IFN-α) to treat stage III malignant melanoma (MM) patients in China. METHODS: Between May 2010 and October 2014, 77 patients of stage III MM who underwent surgery were collected in this study. These patients were divided into two groups: patients who received TIL + IFN-α ± RetroNectin-activated cytokine-induced killer cells (R-CIK) in Arm 1 (n = 27) and IFN-α ± R-CIK in Arm 2 (n = 50) as adjuvant therapy...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28913366/the-differential-contribution-of-the-innate-immune-system-to-a-good-pathological-response-in-the-breast-and-axillary-lymph-nodes-induced-by-neoadjuvant-chemotherapy-in-women-with-large-and-locally-advanced-breast-cancers
#8
Viriya Kaewkangsadan, Chandan Verma, Jennifer M Eremin, Gerard Cowley, Mohammad Ilyas, Sukchai Satthaporn, Oleg Eremin
The tumour microenvironment consists of malignant cells, stroma, and immune cells. The role of adaptive immunity in inducing a pathological complete response (pCR) in breast cancer with neoadjuvant chemotherapy (NAC) is well studied. The contribution of innate immunity, however, is poorly documented. Breast tumours and axillary lymph nodes (ALNs) from 33 women with large and locally advanced breast cancers (LLABCs) undergoing NAC were immunohistochemically assessed for tumour-infiltrating macrophages (TIMs: M1 and M2), neutrophils (TINs), and dendritic cells (TIDCs) using labelled antibodies and semiquantitative methods...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28900629/siae-rare-variants-in-juvenile-idiopathic-arthritis-and-primary-antibody-deficiencies
#9
Eirini Sevdali, Elena Tsitsami, Maria Tsinti, Evangelia Farmaki, Efimia Papadopoulou-Alataki, Anastasios E Germenis, Matthaios Speletas
Sialic acid acetylesterase (SIAE) deficiency was suggested to lower the levels of ligands for sialic acid-binding immunoglobulin-like receptors, decreasing the threshold for B-cell activation. In humans, studies of rare heterozygous loss-of-function mutations in SIAE gene in common autoimmune diseases, including juvenile idiopathic arthritis (JIA), yielded inconsistent results. Considering the distinct pathogenesis of the two main subtypes of JIA, autoinflammatory systemic (sJIA) and autoimmune oligo/polyarticular (aJIA), and a predisposition to autoimmunity displayed by patients and families with primary antibody deficiencies (PADs), the aim of our study was to analyze whether SIAE rare variants are associated with both the phenotype of JIA and the autoimmunity risk in families with PADs...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28894755/cereblon-a-protein-crucial-to-the-multiple-functions-of-immunomodulatory-drugs-as-well-as-cell-metabolism-and-disease-generation
#10
REVIEW
Qinglin Shi, Lijuan Chen
It is well known that cereblon is a key protein in autosomal recessive nonsyndromic mental retardation. Studies have reported that it has an intermediary role in helping immunomodulatory drugs perform their immunomodulatory and tumoricidal effects. In addition, cereblon also regulates the expression, assembly, and activities of other special proteins related to cell proliferation and metabolism, resulting in the occurrence and development of metabolic diseases. This review details the multiple functions of cereblon and the underlying mechanisms...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28894754/natural-modulators-of-endosomal-toll-like-receptor-mediated-psoriatic-skin-inflammation
#11
REVIEW
Chao-Yang Lai, Yu-Wen Su, Kuo-I Lin, Li-Chung Hsu, Tsung-Hsien Chuang
Psoriasis is a chronic inflammatory autoimmune disease that can be initiated by excessive activation of endosomal toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. Therefore, inhibitors of endosomal TLR activation are being investigated for their ability to treat this disease. The currently approved biological drugs adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, and secukizumab are antibodies against effector cytokines that participate in the initiation and development of psoriasis...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28884134/intracellular-ph-regulates-trail-induced-apoptosis-and-necroptosis-in-endothelial-cells
#12
Zhu-Xu Zhang, Ingrid Gan, Alexander Pavlosky, Xuyan Huang, Benjamin Fuhrmann, Anthony M Jevnikar
During ischemia or inflammation of organs, intracellular pH can decrease if acid production exceeds buffering capacity. Thus, the microenvironment can expose parenchymal cells to a reduced extracellular pH which can alter pH-dependent intracellular functions. We have previously shown that while silencing caspase-8 in an in vivo ischemia reperfusion injury (IRI) model results in improved organ function and survival, removal of caspase-8 function in a donor organ can paradoxically result in enhanced receptor-interacting protein kinase 1/3- (RIPK1/3-) regulated necroptosis and accelerated graft loss following transplantation...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28835902/the-microbiome-in-connective-tissue-diseases-and-vasculitides-an-updated-narrative-review
#13
REVIEW
Rossella Talotta, Fabiola Atzeni, Maria Chiara Ditto, Maria Chiara Gerardi, Piercarlo Sarzi-Puttini
OBJECTIVE: To provide a narrative review of the most recent data concerning the involvement of the microbiome in the pathogenesis of connective tissue diseases (CTDs) and vasculitides. METHODS: The PubMed database was searched for articles using combinations of words or terms that included systemic lupus erythematosus, systemic sclerosis, autoimmune myositis, Sjögren's syndrome, undifferentiated and mixed CTD, vasculitis, microbiota, microbiome, and dysbiosis. Papers from the reference lists of the articles and book chapters were reviewed, and relevant publications were identified...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28835901/beneficial-effects-of-prebiotic-saccharomyces-cerevisiae-mannan-on-allergic-asthma-mouse-models
#14
D Betty Lew, Christie F Michael, Tracie Overbeck, W Scout Robinson, Erin L Rohman, Jeffrey M Lehman, Jennifer K Patel, Brandi Eiseman, Kim S LeMessurier, Amali E Samarasinghe, M Waleed Gaber
One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bovine ASM cell proliferation. Using a humanized transgenic mouse strain (huASM-MRC2) expressing the human MRC2 receptor in a SM tissue-specific manner, we have demonstrated that ASM hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with SC-MN treatment...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28815185/saliva-derived-host-defense-peptides-histatin1-and-ll-37-increase-secretion-of-antimicrobial-skin-and-oral-mucosa-chemokine-ccl20-in-an-il-1%C3%AE-independent-manner
#15
Mireille A Boink, Sanne Roffel, Kamran Nazmi, Jan G M Bolscher, Enno C I Veerman, Susan Gibbs
Even though skin and oral mucosae are continuously in contact with commensal and opportunistic microorganisms, they generally remain healthy and uninflamed. Host defense peptides (HDPs) make up the body's first line of defense against many invading pathogens and are involved in the orchestration of innate immunity and the inflammatory response. In this study, we investigated the effect of two salivary HDPs, LL-37 and Hst1, on the inflammatory and antimicrobial response by skin and oral mucosa (gingiva) keratinocytes and fibroblasts...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28812030/safety-of-human-papillomavirus-9-valent-vaccine-a-meta-analysis-of-randomized-trials
#16
REVIEW
Ana Paula Ferreira Costa, Ricardo Ney Oliveira Cobucci, Janine Medeiros da Silva, Paulo Henrique da Costa Lima, Paulo César Giraldo, Ana Katherine Gonçalves
Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safety are rare. Thus, we performed a meta-analysis of three clinical trials assessing adverse effects on women randomly vaccinated with HPV9 or tetravalent vaccine (HPV4), with the objective of analyzing whether the HPV9 is as safe as HPV4...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28804726/low-dose-of-lipopolysaccharide-pretreatment-preventing-subsequent-endotoxin-induced-uveitis-is-associated-with-pi3k-akt-pathway
#17
Nan Zhang, Shuo Yu, Xinli Liu, Hong Lu
PURPOSE: To explore the effects of LPS pretreatment on endotoxin-induced uveitis and PI3K/AKT pathway. METHODS: Endotoxin-induced uveitis was induced by a single subcutaneous injection of 200 μg LPS. For the endotoxin tolerance group, induction of EIU was preceded by daily subcutaneous injection of 0.1 mg/kg LPS for five days. Clinical scores were graded at 24 h after EIU under a slit lamp microscope. HE stain was performed to observe the histopathology. Aqueous humor TNF-α concentration was quantified with enzyme-linked immunosorbent assay...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28791312/synergistic-antitumour-properties-of-viscumtt-in-alveolar-rhabdomyosarcoma
#18
Rahel Mascha Stammer, Susann Kleinsimon, Jana Rolff, Sebastian Jäger, Angelika Eggert, Georg Seifert, Catharina I Delebinski
Aqueous mistletoe extracts from the European mistletoe (Viscum album) contain mainly mistletoe lectins and viscotoxins as cytotoxic compounds. Lipophilic triterpene acids, which do not occur in conventional mistletoe preparations, were solubilised with β-cyclodextrins. The combination of an aqueous extract (viscum) and a triterpene-containing extract (TT) recreated a whole mistletoe extract (viscumTT). These extracts were tested on rhabdomyosarcoma in vitro, ex vivo, and in vivo with regard to anticancer effects...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28785597/mahuang-fuzi-xixin-decoction-attenuates-th1-and-th2-responses-in-the-treatment-of-ovalbumin-induced-allergic-inflammation-in-a-rat-model-of-allergic-rhinitis
#19
Mengyue Ren, Qingfa Tang, Feilong Chen, Xuefeng Xing, Yao Huang, Xiaomei Tan
Allergic rhinitis (AR) is one of the most common allergic diseases, which adversely affect patients' quality of life. Mahuang Fuzi Xixin decoction (MFXD) has been widely used to treat AR in clinics in Asian countries. This study investigated the effect and possible therapeutic mechanisms of MFXD in the treatment of AR. A Wistar rat model of ovalbumin- (OVA-) induced AR was established and then treated with three doses of MFXD; AR symptoms, serum total immunoglobulin E, histamine, histopathological features, and release and expression of factors related to type 1 helper T (Th1) and type 2 helper T (Th2) responses were analyzed...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28785596/characterization-of-interleukin-15-transpresenting-dendritic-cells-for-clinical-use
#20
J M J Van den Bergh, E L J M Smits, M Versteven, H De Reu, Z N Berneman, V F I Van Tendeloo, E Lion
Personalized dendritic cell- (DC-) based vaccination has proven to be safe and effective as second-line therapy against various cancer types. In terms of overall survival, there is still room for improvement of DC-based therapies, including the development of more immunostimulatory DC vaccines. In this context, we redesigned our currently clinically used DC vaccine generation protocol to enable transpresentation of interleukin- (IL-) 15 to IL-15Rβγ-expressing cells aiming at boosting the antitumor immune response...
2017: Journal of Immunology Research
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