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Journal of Immunology Research

Mario Delia, Paola Carluccio, Anna Mestice, Claudia Brunetti, Francesco Albano, Giorgina Specchia
Acute myeloid leukemia (AML) is widely considered a distinct clinical entity with a well-defined molecular and genetics-based prognosis. Particularly in a younger patient, the therapeutic approach depends largely on diagnostic risk stratification, which has an impact on the outcome after therapy. We added Treg evaluation to the usual molecular and cytogenetics profile in the AML younger patients' diagnostic bone marrow aspirate (dBMA) in order to search for any correlation between Tregs and overall response (OR) as well as survival (OS) rates...
2018: Journal of Immunology Research
Mohamad Alaa Terkawi, Ryo Takano, Kentaro Kato
Neutrophils (PMNs) are the most abundant cellular component of our innate immune system, where they play central roles in the pathogenesis of and resistance to a broad range of diseases. However, their roles in malarial infection remain poorly understood. Therefore, we examined the transcriptional gene profile of human PMNs in response to Plasmodium falciparum -parasitized erythrocytes (iRBCs) by using oligonucleotide microarrays. Results revealed that PMNs induced a broad and vigorous set of changes in gene expression in response to malarial parasites, represented by 118 upregulated and 216 downregulated genes...
2018: Journal of Immunology Research
Yan-Jie Zhao, Jian Zhang, Feng Shi, Zhi-Ping Hu, Jiang-Ping Wu, Guang-Jiang Wu, Rui-Bin Wang, Quan Zhou, Hong Chang, Ying-Nan Li, Qing-Kun Song
Objective: This study aimed to investigate the correlation of CD4+ /PD-1+ or CD4+ /PD-1- tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods: A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed cell death protein 1 (PD-1), CK7, CK20, E-cadherin, or Ki-67 was detected by immunohistochemistry. The associations between CD4+ /PD-1+ or CD4+ /PD-1- tumor-infiltrating lymphocytes and pathological characteristics were evaluated...
2018: Journal of Immunology Research
Longzhen He, Baocheng Wang, Yuanyuan Li, Leqing Zhu, Peiling Li, Feiyan Zou, Lianghua Bin
The innate immune response is the first line defense against viral infections. Novel genes involved in this system are continuing to emerge. SLC15A3, a proton-coupled histidine and di-tripeptide transporter that was previously found in lysosomes, has been reported to inhibit chikungunya viral replication in host cells. In this study, we found that SLC15A3 was significantly induced by DNA virus herpes simplex virus-1(HSV-1) in monocytes from human peripheral blood mononuclear cells. Aside from monocytes, it can also be induced by HSV-1 in 293T, HeLa cells, and HaCaT cells...
2018: Journal of Immunology Research
Xiang You, Dan Dan Xu, Di Zhang, Jie Chen, Feng Guang Gao
PYR-41 and thalidomide have therapeutic effects on inflammation-associated diseases with side effects such as tumorigenesis. Cross-presentation allows dendritic cells (DC) to present endogenous antigen and induce protective immunity against microbe infection and tumors. But, up to now, the effects of PYR-41 and thalidomide on cross-presentation are still uncertain. In this study, we investigated the effect and mechanism of PYR-41 and thalidomide on DC cross-presentation by observing Myddosome formation, endosomal recruitment of p97 and Sec61, NF- κ B activation, and cross-priming ability...
2018: Journal of Immunology Research
Mamiko Niki, Takashi Yoshiyama, Yuji Miyamoto, Masao Okumura, Makoto Niki, Ken-Ichi Oinuma, Yukihiro Kaneko, Sohkichi Matsumoto, Yuka Sasaki, Hideo Ogata, Hajime Goto, Shoji Kudoh, Yoshihiko Hoshino
A novel tuberculosis vaccine to replace BCG has long been desired. However, recent vaccine trials focused on cell-mediated immunity have failed to produce promising results. It is worth noting that most commercially available successful vaccines rely on humoral immunity. To establish a basic understanding of humoral immunity against tuberculosis, we analyzed and evaluated longitudinal levels and avidity of immunoglobulin to various tuberculosis antigens compared with bacterial and clinical parameters during treatment...
2018: Journal of Immunology Research
Markos Negash, Tadelo Wondmagegn, Demeke Geremew
Background: Syphilis is a sexually transmitted disease (STD) caused by the spirochete Treponema pallidum , and it persists to be a major public health problem in Africa, including Ethiopia. Syphilis diagnosis is made by either nontreponemal or treponemal approaches, though in developing countries the diagnosis relies mostly on nonspecific tests due to several reasons. Thus, the objective of this study was to assess the sensitivity, specificity, predictive values, and agreement of rapid plasma reagin (RPR) and enzyme-linked immunosorbent assay (ELISA) with Treponema pallidum hemagglutination assay (TPHA) as a gold standard for the diagnosis of syphilis...
2018: Journal of Immunology Research
Ayana N Martin, Martha Alexander-Miller, Barbara K Yoza, Vidula Vachharajani, Charles E McCall
Resistance and tolerance to infection are two universal fitness and survival strategies used by inflammation and immunity in organisms and cells to guard homeostasis. During sepsis, however, both strategies fail, and animal and human victims often die from combined innate and adaptive immune suppression with persistent bacterial and viral infections. NAD+ -sensing nuclear sirtuin1 (SIRT1) epigenetically guards immune and metabolic homeostasis during sepsis. Pharmacologically inhibiting SIRT1 deacetylase activity in septic mice reverses monocyte immune tolerance, clears infection, rebalances glycolysis and glucose oxidation, resolves organ dysfunction, and prevents most septic deaths...
2018: Journal of Immunology Research
Leandro Borges, Alexandre Dermargos, Stuart Gray, Maysa B Barros Silva, Vinicius Santos, Tania Cristina Pithon-Curi, Renata Gorjão, Elaine Hatanaka
The physical demands of street dancing may result in inflammation and changes in leukocyte numbers/function, impairing the health of dancers. Herein, we investigated the effect of street dancing on inflammation, adhesion molecules, and neutrophil function. Fifteen amateur dancers (mean ± SE: age 22.4 ± 1.08 years, BMI 24.8 ± 0.69 kg/m2 , and body fat 12.3 ± 1.52%) participated in a single high-intensity street dance class. Blood samples were taken before and after the class. The dance class had no effect on the plasma concentration of CRP, TNF- α , IL-6, IL-10, and IL-8; however, we noted an increase in levels of IL-1 β (4...
2018: Journal of Immunology Research
Fareeha Azam, Nadeem Sheikh, Gibran Ali, Asima Tayyeb
Fagonia indica is a traditionally used phytomedicine to cure hepatic ailments. However, efficient validation of its hepatoprotective effect and molecular mechanisms involved are not yet well established. Therefore, the present study was designed to evaluate the hepatoprotective activity of Fagonia indica and to understand the molecular mechanisms involved in the reversal of hepatic injury. The liver injury mouse model was established by thioacetamide followed by oral administration of plant extract. Serum biochemical and histological analyses were performed to assess the level of hepatic injury...
2018: Journal of Immunology Research
Haniye Ghasiyari, Mohammad Rostami-Nejad, Davar Amani, Kamran Rostami, Mohamad Amin Pourhoseingholi, Hamid Asadzadeh-Aghdaei, Mohammad Reza Zali
Background and Aims: Both adaptive and innate immunity are involved in the development of celiac disease (CD). Altered Toll-like receptors (TLR) expression and activation may be partially responsible for the inflammation and subsequently crypt hyperplasia, but the main driver for inflammation is gliadin-reactive T-cells. Therefore, the aim of this study was to investigate the TLRs 2, 4, 7, and 9 gene expressions in both peripheral blood and intestinal mucosa of patients with celiac disease compared to healthy control (HC)...
2018: Journal of Immunology Research
Xueyang Zou, Guangyu Sun, Feifei Huo, Lu Chang, Wei Yang
T follicular helper cells (TFH ) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFH cells are clear. However, the early differentiation of these cells is not clear. Dendritic cells (DCs) participate in the differentiation of TFH cells. Therefore, this article reviewed the research progress regarding the influence of DCs on the differentiation of TFH cells and their major underlying mechanisms...
2018: Journal of Immunology Research
Naoki Hosaka
We recently developed a new allogeneic hematopoietic stem cell transplantation method (allo-HSCT) combined with thymus transplantation (TT) from the same donor (allo-HSCT + TT). This method induces elevated T cell function with mild graft-versus-host disease (GVHD) in comparison to conventional HSCT alone and HSCT + donor lymphocyte infusion (DLI). This new method is effective against several intractable diseases, including malignant tumors, for which conventional treatments are ineffective. Regulatory T (Treg ) cells play an important role in the enhanced graft-versus-tumor (GVT) effect and reduction of GVHD, thus leading to longer survival...
2018: Journal of Immunology Research
Yu Yang, Peng-Lei Xiao, Ya Yang, Jian-Chuan Gao, Yan Shi, Wan-Ting Cheng, Yue Chen, Xiu-Xia Song, Qing-Wu Jiang, Yi-Biao Zhou
Objective: To explore the association between infections with HIV and Schistosoma japonicum , and to determine the influences of the HIV- S. japonicum coinfections on the immune system of Yi people. Methods: A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and S. japonicum in China. All participants were screened for HIV antibodies and S. japonicum antibodies (SjAb) and were classified into four groups: HIV(+)/ S...
2018: Journal of Immunology Research
Fan Yang, Yang Li, Qian Zhang, Liang Tan, Longkai Peng, Yong Zhao
Myeloid-derived suppressor cells (MDSCs) are a group of innate immune cells that regulates both innate and adaptive immune responses. In recent years, MDSCs were shown to play an important negative regulatory role in transplant immunology even upstream of regulatory T cells. In certain cases, MDSCs are closely involved in transplantation immune tolerance induction and maintenance. It is known that some immunosuppressant drugs negatively regulate MDSCs but others have positive effects on MDSCs in different transplant cases...
2018: Journal of Immunology Research
Liqian Zhu, Clinton Jones, Gaiping Zhang
Macrophages are crucial members of the mononuclear phagocyte system essential to protect the host from invading pathogens and are central to the inflammatory response with their ability to acquire specialized phenotypes of inflammatory (M1) and anti-inflammatory (M2) and to produce a pool of inflammatory mediators. Equipped with a broad range of receptors, such as Toll-like receptor 4 (TLR4), CD14, and Fc gamma receptors (Fc γ Rs), macrophages can efficiently recognize and phagocytize invading pathogens and secrete cytokines by triggering various secondary signaling pathways...
2018: Journal of Immunology Research
Marion Rolot, Benjamin G Dewals
Macrophages are highly plastic innate immune cells that adopt an important diversity of phenotypes in response to environmental cues. Helminth infections induce strong type 2 cell-mediated immune responses, characterized among other things by production of high levels of interleukin- (IL-) 4 and IL-13. Alternative activation of macrophages by IL-4 in vitro was described as an opposite phenotype of classically activated macrophages, but the in vivo reality is much more complex. Their exact activation state as well as the role of these cells and associated molecules in type 2 immune responses remains to be fully understood...
2018: Journal of Immunology Research
Nina Pilat, Benedikt Mahr, Martina Gattringer, Ulrike Baranyi, Thomas Wekerle
Blockade of the CD28:CD80/86 costimulatory pathway has been shown to be potent in blocking T cell activation in vitro and in vivo . The costimulation blocker CTLA4Ig has been approved for the treatment of autoimmune diseases and transplant rejection. The therapeutic application of regulatory T cells (Tregs) has recently gained much attention for its potential of improving allograft survival. However, neither costimulation blockade with CTLA4Ig nor Treg therapy induces robust tolerance on its own. Combining CTLA4Ig with Treg therapy would be an attractive approach for minimizing immunosuppression or for possibly achieving tolerance...
2018: Journal of Immunology Research
Yanhua Zheng, Hongyuan Shen, Li Xu, Juan Feng, Hailong Tang, Na Zhang, Xiequn Chen, Guangxun Gao
During the past decades, agents with novel mechanisms of action, such as monoclonal antibodies (MAbs) and histone deacetylase inhibitors (HDACis) have been applied to treat relapsed or refractory multiple myeloma (RRMM). The treatment outcomes of MAbs versus HDACi in combination with bortezomib or lenalidomide plus dexamethasone remain unknown. We conducted this meta-analysis to compare indirectly the efficacy and safety of MAbs and HDACis in combination with bortezomib or lenalidomide plus dexamethasone. Six trials (eight articles) were included in the meta-analysis with 3270 RRMM patients enrolled...
2018: Journal of Immunology Research
Shang-Chen Yang, Sindy Hu, Sheng-Zheng Zhang, Jin-Wen Huang, Jing Zhang, Chao Ji, Bo Cheng
[This corrects the article DOI: 10.1155/2018/4320195.].
2018: Journal of Immunology Research
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