journal
https://read.qxmd.com/read/38361183/a-novel-human-il-23a-overexpressing-mouse-model-of-systemic-lupus-erythematosus
#21
JOURNAL ARTICLE
Eleni Christodoulou-Vafeiadou, Christina Geka, Lida Iliopoulou, Lydia Ntari, Maria C Denis, Niki Karagianni, George Kollias
OBJECTIVE: Interleukin-23 (IL-23) is a crucial cytokine implicated in chronic inflammation and autoimmunity, associated with various diseases like psoriasis, psoriatic arthritis, and systemic lupus erythematosus (SLE). This study aimed to create and characterize a transgenic mouse model (TghIL23A) overexpressing human IL23A, providing a valuable tool for investigating the pathogenic role of hIL23A and evaluating the efficacy of anti-human-IL23A therapeutics. METHODS: TghIL23A mice were generated via microinjection of CBAxC57BL/6 zygotes with a fragment of the human IL23A gene, flanked by its 5'-regulatory sequences and the 3'UTR of human beta-globin...
February 15, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38360061/pulmonary-damage-biomarkers-for-risk-of-rheumatoid-arthritis-associated-interstitial-lung-disease-enabling-early-detection-and-risk-stratification
#22
EDITORIAL
Pierre-Antoine Juge, Paul F Dellaripa, Jeffrey A Sparks
No abstract text is available yet for this article.
February 15, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38351478/reply-to-comment-on-both-disease-activity-and-hla-b27-status-are-associated-with-gut-microbiome-dysbiosis-in-spondyloarthritis-patients-by-y-zheng-j-he-and-l-li
#23
LETTER
Magali Berland, Dusko Ehrlich, Maxime Breban
No abstract text is available yet for this article.
February 13, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38351441/reply
#24
LETTER
Jörg H W Distler, Jonas Hallén
No abstract text is available yet for this article.
February 13, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38351307/comment-on-both-disease-activity-and-hla-b27-status-are-associated-with-gut-microbiome-dysbiosis-in-spondyloarthritis-patients
#25
LETTER
Yi Zheng, Jun He, Liqi Li
No abstract text is available yet for this article.
February 13, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38351303/comment-on-anti-s100a4-monoclonal-antibody-treatment-ameliorates-experimental-skin-fibrosis-and-ssc-specific-transcriptional-signatures-in-human-skin
#26
LETTER
An-Fang Huang, Wang-Dong Xu
No abstract text is available yet for this article.
February 13, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38343350/dna-damage-and-cellular-senescence-in-osteoarthritis-an-unexpected-role-for-interferon-regulatory-factor-1-in-chondrocyte-dna-repair
#27
EDITORIAL
Brian O Diekman, Richard F Loeser
No abstract text is available yet for this article.
February 12, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38343337/clinical-characteristics-and-outcomes-of-polyarteritis-nodosa-an-international-study
#28
JOURNAL ARTICLE
Omer Karadag, Ertugrul Cagri Bolek, Gizem Ayan, Aladdin J Mohammad, Peter C Grayson, Christian Pagnoux, Eduardo Martín-Nares, Sara Monti, Yoshiyuki Abe, Federico Alberici, Fatma Alibaz-Oner, David Cuthbertson, Lorenzo Dagna, Haner Direskeneli, Nader A Khalidi, Curry Koening, Carol A Langford, Carol A McAlear, Paul A Monach, Luca Moroni, Roberto Padoan, Phillip Seo, Kenneth J Warrington, Alojzija Hocevar, Andrea Hinojosa-Azaola, Shunsuke Furuta, Giacomo Emmi, Seza Ozen, David Jayne, Peter A Merkel
OBJECTIVE: We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL-PAN). METHODS: Patients with PAN were recruited between 1990 and 2020 from observational cohorts of nine countries across Europe, Japan, and North America. Eligibility was retrospectively defined using the European Medicines Agency classification algorithm. Patients with PAN related to hepatitis B virus (n = 12) and two monogenic diseases mimicking PAN, deficiency of adenosine deaminase 2 enzyme (n = 16) or familial Mediterranean fever (n = 11), were excluded...
February 12, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38327016/using-two-predictive-models-captures-two-types-of-poor-outcomes-in-knee-arthroplasty-a-multisite-longitudinal-cohort-study
#29
JOURNAL ARTICLE
Daniel L Riddle, Levent Dumenci
OBJECTIVES: Poor outcome following knee arthroplasty (KA), a common major surgery worldwide, reportedly occurs in approximately 20% of cases. These patients demonstrate minimal improvement, at least moderate knee pain, and difficulty performing many routine daily activities. The purposes of our study were to comprehensively determine poor outcome risk following KA and to identify predictors of poor outcome. METHODS: Data from 565 participants with KA in the Osteoarthritis Initiative and the Multicenter Osteoarthritis studies were used...
February 7, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38321957/decoding-sj%C3%A3-gren-s-syndrome-a-comprehensive-approach-to-multiparametric-diagnosis
#30
LETTER
Ranjeet Singh Mahla
No abstract text is available yet for this article.
February 7, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38321927/enhancing-sj%C3%A3-gren-s-disease-diagnosis-through-the-convergence-of-multiparametric-approaches-and-big-data-intelligence
#31
LETTER
Eléonore Bettacchioli, Alain Saraux, Nathan Foulquier, Divi Cornec, Valérie Devauchelle-Pensec
No abstract text is available yet for this article.
February 7, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38317300/clinical-images-a-strange-reaction-after-a-hyaluronic-acid-injection
#32
JOURNAL ARTICLE
Marie Piroth, Youta Fanjat, Nathalie Cardot-Leccia, Christian Roux, Thierry Passeron
No abstract text is available yet for this article.
February 5, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38282549/the-exposome-what-is-it-really-and-does-it-help-to-understand-environmental-influences-on-human-health-and-rheumatic-disease
#33
EDITORIAL
Christine G Parks, Karen H Costenbader
No abstract text is available yet for this article.
January 29, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38272846/vitamin-d-and-marine-n-3-fatty-acids-for-autoimmune-disease-prevention-outcomes-at-two-years-after-vital-trial-completion
#34
JOURNAL ARTICLE
Karen H Costenbader, Nancy R Cook, I-Min Lee, Jill Hahn, Joseph Walter, Vadim Bubes, Gregory Kotler, Nicole Yang, Sonia Friedman, Erik K Alexander, JoAnn E Manson
OBJECTIVE: In the 5.3 year randomized, 2 x 2 factorial, double-blind, placebo-controlled VITamin D and OmegA-3 TriaL (VITAL), vitamin D supplementationreduced autoimmune disease (AD) incidence (hazard ratio [HR] 0.78, 95% confidence interval 0.61-0.99). Omega-3(n-3) fatty acid supplementation showed a statistically non-significant reduction (HR 0.85, 0.67-1.08). We aimed to confirm further AD cases arising during and after randomization and assess sustained effects with 2 years of post-intervention observation...
January 25, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38272842/myositis-associated-autoantibodies-in-patients-with-juvenile-myositis-are-associated-with-refractory-disease-and-mortality
#35
JOURNAL ARTICLE
Matthew A Sherman, Payam Noroozi Farhadi, Katherine Pak, Edward P Trieu, Kakali Sarkar, Ira N Targoff, Megan L Neely, Andrew L Mammen, Lisa G Rider
OBJECTIVE: Myositis-associated autoantibodies (MAAs) have been associated with overlap myositis, certain disease manifestations such as interstitial lung disease (ILD), and worse prognosis in the idiopathic inflammatory myopathies. MAAs overall remain largely uncharacterized in patients with juvenile-onset myositis. Moreover, it is unknown whether the number of MAAs is associated with disease severity. METHODS: Patients with juvenile myositis in cross-sectional natural history studies who underwent testing for myositis autoantibodies were included...
January 25, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38272838/hydroxychloroquine-in-lupus-pregnancy-and-risk-of-preeclampsia
#36
JOURNAL ARTICLE
Amadeia Rector, Ivana Marić, Yashaar Chaichian, Eliza Chakravarty, Miranda Cantu, Michael H Weisman, Gary M Shaw, Maurice L Druzin, Julia F Simard
OBJECTIVE: Systemic lupus erythematosus (SLE) disproportionately affects women during childbearing years, and hydroxychloroquine (HCQ) is the standard first-line treatment. Preeclampsia complicates up to one-third of pregnancies in lupus patients, although reports vary by parity and multifetal gestation. We investigated whether taking HCQ early in pregnancy may reduce the risk of preeclampsia. METHODS: We studied 1,068 live birth singleton pregnancies among 1,020 privately insured patients with SLE (2007-2016)...
January 25, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38272830/erosive-tophaceous-gout-and-uric-acid-nephrolithiasis-microscopic-and-3d-hrpqct-findings
#37
JOURNAL ARTICLE
Giovanni Adami, Francesca Ruzzon, Angelo Fassio, Davide Gatti, Matteo Gatti, Maurizio Rossini
No abstract text is available yet for this article.
January 25, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38272827/the-effect-of-recent-antirheumatic-drug-on-features-of-rheumatoid-arthritis-associated-lymphoproliferative-disorders
#38
JOURNAL ARTICLE
Yoshihiko Hoshida, Atsuko Tsujii, Shiro Ohshima, Yukihiko Saeki, Masato Yagita, Tomoya Miyamura, Masao Katayama, Tomonori Kawasaki, Yasushi Hiramatsu, Hisaji Oshima, Toshihiko Murayama, Shinji Higa, Kazuya Kuraoka, Fuminori Hirano, Kenji Ichikawa, Mitsutoshi Kurosawa, Hiroaki Suzuki, Noriyuki Chiba, Takao Sugiyama, Yuko Minami, Hitoshi Niino, Atsushi Ihata, Ikuo Saito, Akiko Mitsuo, Toshitaka Maejima, Atsuhiro Kawashima, Hiroshi Tsutani, Koichiro Takahi, Takahiko Kasai, Yoko Shinno, Yoshiro Tachiyama, Norihiro Teramoto, Kenichi Taguchi, Shinji Naito, Shigeru Yoshizawa, Masahiro Ito, Yasuo Suenaga, Shunsuke Mori, Shoichi Nagakura, Norie Yoshikawa, Mitsuharu Nomoto, Atsuhisa Ueda, Shouhei Nagaoka, Yukio Tsuura, Keigo Setoguchi, Shoji Sugii, Asami Abe, Toshiaki Sugaya, Hiroyuki Sugahara, Shigeki Fujita, Yasuo Kunugiza, Norishige Iizuka, Ryosuke Yoshihara, Hiroki Yabe, Tomoaki Fujisaki, Eiichi Morii, Morishige Takeshita, Masakazu Sato, Kazuyoshi Saito, Kiyoshi Matsui, Yasuhiko Tomita, Hiroshi Furukawa, Shigeto Tohma
PURPOSE: In this study, we examine how advancements in novel antirheumatic drugs affect the clinicopathological features of lymphoproliferative disorder (LPD) in patients with rheumatoid arthritis (RA-LPD). METHODS: In this multicenter study across 48 hospitals in Japan, we characterized patients with RA who developed LPDs and visited the hospitals between January 1999 and March 2021. The statistical tools used included Fisher's exact test, Mann-Whitney U-test, log-rank test, logistic regression analysis, and Cox proportional hazards models...
January 25, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38268504/clinical-characteristics-of-cryopyrin-associated-periodic-syndrome-and-long-term-real-world-efficacy-and-tolerability-of-canakinumab-in-japan-results-of-a-nationwide-survey
#39
JOURNAL ARTICLE
Takayuki Miyamoto, Kazushi Izawa, Sho Masui, Atsue Yamazaki, Yuichi Yamasaki, Tadashi Matsubayashi, Mayuka Shiraki, Hidenori Ohnishi, Junko Yasumura, Kawabe Tomohiro, Takako Miyamae, Tomoyo Matsubara, Naoya Arakawa, Takashi Ishige, Takumi Takizawa, Asami Shimbo, Masaki Shimizu, Naoki Kimura, Yuichi Maeda, Yuta Maruyama, Tomonari Shigemura, Junichi Furuta, Satoshi Sato, Hiroshi Tanaka, Miharu Izumikawa, Masahiro Yamamura, Toshio Hasegawa, Hiroshi Kaneko, Yasuo Nakagishi, Naoko Nakano, Yasunori Iida, Tamaki Nakamura, Hiroyuki Wakiguchi, Takayuki Hoshina, Toshinao Kawai, Kosaku Murakami, Shuji Akizuki, Akio Morinobu, Koichiro Ohmura, Katsuhide Eguchi, Motoshi Sonoda, Masataka Ishimura, Kenji Furuno, Momoko Kashiwado, Masaaki Mori, Kimito Kawahata, Koremasa Hayama, Kumiko Shimoyama, Natsuko Sasaki, Taisuke Ito, Hiroaki Umebayashi, Tae Omori, Seiko Nakamichi, Tomotsune Dohmoto, Yasuyuki Hasegawa, Hisashi Kawashima, Shojiro Watanabe, Yuichiro Taguchi, Haruna Nakaseko, Naomi Iwata, Hiroki Kohno, Taiki Ando, Yasuhiko Ito, Yuko Kataoka, Takako Saeki, Utako Kaneko, Ayako Murase, Seira Hattori, Tomo Nozawa, Kenichi Nishimura, Reiji Nakano, Misa Watanabe, Masato Yashiro, Tomonori Nakamura, Toshihiko Komai, Kentaro Kato, Yoshitaka Honda, Eitaro Hiejima, Atsushi Yonezawa, Kazuhisa Bessho, Satoshi Okada, Osamu Ohara, Junko Takita, Takahiro Yasumi, Ryuta Nishikomori
OBJECTIVE: To assess the clinical characteristics of patients with cryopyrin-associated periodic syndrome (CAPS) in Japan and evaluate the real-world efficacy and safety of interleukin (IL)-1 inhibitors, primarily canakinumab. METHODS: Clinical information was collected retrospectively, and serum concentrations of canakinumab and cytokines were analyzed. RESULTS: One-hundred-and-one patients were included, with 86 and 15 carrying heterozygous germline and somatic mosaic mutations, respectively...
January 25, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38268500/ccl19-positive-lymph-node-stromal-cells-govern-the-onset-of-inflammatory-arthritis-via-tropomyosin-receptor-kinase
#40
JOURNAL ARTICLE
Fabian Schälter, Vugar Azizov, Michael Frech, Kerstin Dürholz, Eva Schmid, Anna Hendel, Ilann Sarfati, Yuichi Maeda, Maria Sokolova, Ippei Miyagawa, Kristin Focke, Kerstin Sarter, Lisa G M van Baarsen, Stefan Krautwald, Georg Schett, Mario M Zaiss
OBJECTIVES: To assess the role of CCL19+ lymph node stromal cells of the joint draining popliteal lymph node (pLN) for the development of arthritis. METHODS: CCL19+ lymph node stromal cells were spatiotemporally depleted for 5 days in the pLN before the onset of collagen-induced arthritis (CIA) using Ccl19-Cre x iDTR mice. In addition, therapeutic treatment with recombinant CCL19-IgG, locally injected in the footpad, was used to confirm the results. RNA sequencing of lymph node stromal cells combined with T cell co-culture assays using tropomyosin receptor kinase (Trk) family inhibitors together with in vivo local pLN siRNA treatments were used to elucidate the pathway by which CCL19+ lymph node stromal cells initiate the onset of arthritis...
January 25, 2024: Arthritis & Rheumatology
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