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Arthritis & Rheumatology

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https://www.readbyqxmd.com/read/27907269/remission-rates-with-tofacitinib-treatment-in-rheumatoid-arthritis-a-comparison-of-various-remission-criteria
#1
Josef S Smolen, Daniel Aletaha, David Gruben, Samuel H Zwillich, Sriram Krishnaswami, Charles Mebus
OBJECTIVE: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Throughout tofacitinib clinical studies, a 28-joint Disease Activity Score (DAS28)-based analysis was used to assess outcomes. In this study, remission rates by various remission criteria were evaluated across five Phase 3 randomized controlled studies. METHODS: Tofacitinib was dosed 5 or 10 mg twice daily (BID), either as monotherapy, or with background methotrexate or other conventional synthetic disease-modifying antirheumatic drugs (DMARDs)...
December 1, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27907250/the-transcriptional-co-activator-bob1-is-associated-with-pathologic-b-cell-responses-in-autoimmune-tissue-inflammation
#2
Maria J Levels, Melissa N Van Tok, Tineke Cantaert, Juan D Cañete, Frans G M Kroese, Kristine Germar, Hergen Spits, Dominique L P Baeten, Nataliya G Yeremenko
OBJECTIVE: The molecular mechanisms steering abnormal B cell responses in autoimmune diseases remain poorly understood. In this study we aimed to identify molecular switches controlling pathological B cell responses in rheumatoid arthritis (RA). METHODS: Candidate molecules were identified by gene expression profiling of RA synovitis and validated by qPCR and immunohistochemistry. B cell-specific expression was confirmed by immunofluorescence, immunoblotting and flow cytometry...
December 1, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27899010/biomarkers-as-entry-criteria-for-clinical-trials-of-new-therapies-for-systemic-lupus-erythematosus-the-example-of-ana-and-anti-dna
#3
REVIEW
David S Pisetsky, Brad H Rovin, Peter E Lipsky
No abstract text is available yet for this article.
November 29, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27894157/relationship-between-serum-infliximab-concentrations-and-risk-of-infections-in-patients-treated-for-spondyloarthritis
#4
Theodora Bejan-Angoulvant, David Ternant, Fadela Daoued, Frédéric Medina, Louis Bernard, Saloua Mammou, Gilles Paintaud, Denis Mulleman
OBJECTIVE: Tumor necrosis factor inhibitors are effective in reducing inflammation in rheumatic diseases but increase the risk of infections. This study was undertaken to investigate the relationship between the trough serum concentration of infliximab (IFX) and the risk of a first infection episode. METHODS: We retrospectively included all patients who started IFX treatment for an approved indication in our department. Patients were followed up based on recommended IFX infusion schedules...
November 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27875653/low-progression-rate-to-ankylosing-spondylitis-as-in-patients-with-presumable-non-radiographic-axial-spondyloarthritis-nr-axspa
#5
LETTER
Juergen Braun, Joachim Sieper
No abstract text is available yet for this article.
November 22, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27875629/reply-to-drs-braun-and-seiper
#6
LETTER
Runsheng Wang, Michael M Ward
No abstract text is available yet for this article.
November 22, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863183/evidence-for-immune-relevance-of-prevotella-copri-a-gut-microbe-in-patients-with-rheumatoid-arthritis
#7
Annalisa Pianta, Sheila Arvikar, Klemen Strle, Elise E Drouin, Qi Wang, Catherine E Costello, Allen C Steere
OBJECTIVE: Prevotella copri, an intestinal microbe, may over-expand in stool samples of patients with new-onset rheumatoid arthritis (NORA), but it is not yet clear whether the organism has immune relevance in RA pathogenesis. METHODS: HLA-DR-presented peptides (T cell epitopes) from P. copri were sought directly from patients' synovial tissue or peripheral blood mononuclear cells (PBMC) using tandem mass spectrometry, followed by testing the antigenicity of peptides or their source proteins using samples from RA patients or comparison groups...
November 18, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863174/soluble-mediators-and-clinical-features-discern-risk-of-transitioning-to-classified-disease-in-relatives-of-systemic-lupus-erythematosus-patients
#8
Melissa E Munroe, Kendra A Young, Diane L Kamen, Joel M Guthridge, Timothy B Niewold, Karen H Costenbader, Michael H Weisman, Mariko L Ishimori, Daniel J Wallace, Gary S Gilkeson, David R Karp, John B Harley, Jill M Norris, Judith A James
OBJECTIVE: Systemic lupus erythematosus (SLE) and other autoimmune diseases cause significant morbidity. Identifying populations at risk of developing SLE is essential to curtail irreversible inflammatory damage. The objective of this study was to identify factors associated with transition to classified disease that inform SLE risk. METHODS: Previously identified lupus patient blood relatives with < 4 American College of Rheumatology SLE classification criteria at baseline (n=409) were enrolled in this follow-up study...
November 18, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863170/who-gets-sle-clues-to-a-tantalizing-syndrome
#9
EDITORIAL
Ronald F van Vollenhoven
No abstract text is available yet for this article.
November 18, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863149/cgas-expression-in-patients-with-systemic-lupus-erythematosus
#10
Jie An, Laura Durcan, Reynold M Karr, Tracy A Briggs, Gillian I Rice, Thomas H Teal, Joshua J Woodward, Keith B Elkon
OBJECTIVES Type I interferon (IFN-I) is implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE) and 'interferonopathies' such as Aicardi-Goutieres Syndrome. A recently discovered DNA-activated IFN-I pathway, cyclic GMP-AMP (cGAMP) synthase (cGAS) is linked to AGS and mouse models of lupus. The aim of this study was to determine whether the cGAS pathway contributes to IFN-I production in SLE patients. METHODS SLE disease activity was measured by SELENA-SLEDAI. cGAS and interferon stimulated gene (ISG) mRNA expression was quantified by quantitative PCR ...
November 18, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27860410/sarilumab-and-non-biologic-disease-modifying-antirheumatic-drugs-in-patients-with-active-ra-and-inadequate-response-or-intolerance-to-tnf-inhibitors
#11
Roy Fleischmann, Janet van Adelsberg, Yong Lin, Geraldo da Rocha Castelar-Pinheiro, Jan Brzezicki, Pawel Hrycaj, Neil M H Graham, Hubert van Hoogstraten, Deborah Bauer, Gerd R Burmester
OBJECTIVE: To evaluate efficacy and safety of sarilumab plus conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) in patients with active, moderate-to-severe rheumatoid arthritis (RA) with inadequate response or intolerance to anti-tumor necrosis factor (TNF) therapies. METHODS: Patients were randomly allocated to receive sarilumab 150 mg, sarilumab 200 mg, or placebo every 2 weeks (q2w) for 24 weeks with background csDMARD(s). Coprimary endpoints were proportion of patients achieving American College of Rheumatology 20% (ACR20) response at week 24 and change from baseline in Health Assessment Questionnaire-Disability Index (HAQ-DI) at week 12...
November 17, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27860469/cutaneous-lymphangiectasia-in-association-with-systemic-sclerosis
#12
Sabrina Hoa, Valerie Leclair, Marie Hudson
No abstract text is available yet for this article.
November 16, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27860453/targeting-the-d-series-resolvin-receptor-system-for-the-treatment-of-osteoarthritic-pain
#13
Junting Huang, James J Burston, Li Li, Sadaf Ashraf, Paul I Mapp, Andrew J Bennett, Srinivasarao Ravipati, Petros Pousinis, David A Barrett, Brigitte E Scammell, Victoria Chapman
OBJECTIVE: Pain is a major symptom of osteoarthritis (OA); current analgesics either do not offer adequate pain relief or are associated with serious side effects. Herein we have investigated the therapeutic potential of targeting the resolvin receptor system to modify OA pain and pathology. METHODS: Gene expression of two resolvin receptors (ALX and ChemR23) was quantified in synovia and medial tibial plateau collected from patients at joint replacement for OA...
November 16, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27860437/no-association-of-fibromyalgia-and-seronegative-rheumatoid-arthritis-the-need-for-uniform-application-of-fibromyalgia-criteria-in-research-studies
#14
LETTER
Frederick Wolfe, Brian Walitt
No abstract text is available yet for this article.
November 16, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27860433/whipple-destructive-septic-arthritis
#15
Xavier Puéchal, Jonathan London
No abstract text is available yet for this article.
November 16, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27860419/response-to-letter-from-drs-wolfe-and-walitt
#16
LETTER
Jayanth Doss, Huan Mo, Robert J Carroll, Leslie J Crofford, Joshua C Denny
No abstract text is available yet for this article.
November 16, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863169/caution-is-needed-in-diagnosing-igg4-related-disease-a-possible-paraneoplastic-syndrome
#17
LETTER
Yiwen Wang, Jian Zhu
No abstract text is available yet for this article.
November 11, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863157/letter-to-the-editor
#18
LETTER
Carl Tuttle
No abstract text is available yet for this article.
November 11, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863141/uvb-irradiation-causes-sting-dependent-production-of-protective-type-1-interferon-in-the-skin-by-recruited-inflammatory-monocytes
#19
Clayton Sontheimer, Denny Liggitt, Keith B Elkon
Objective Photosensitivity is common in patients with systemic lupus, though the mechanisms linking ultraviolet light to flares is not well understood. Here, we asked whether repetitive UVB exposure could induce Type I interferon (IFN-I) in normal mouse skin, and investigated the roles of inflammatory monocytes and plasmacytoid dendritic cells (PDCs) in IFN-I production and development of UVB-induced inflammation. Methods Mice were irradiated with UVB at 100 mJ/cm(2) for five days and cutaneous manifestations examined by mRNA expression of inflammatory and IFN-I response genes, histology, and flow cytometry...
November 11, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863140/letter-to-the-editor-reply-to-tuttle
#20
LETTER
Sheila L Arvikar, Allen C Steere
No abstract text is available yet for this article.
November 11, 2016: Arthritis & Rheumatology
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