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Arthritis & Rheumatology

Hanbo Yang, Xin Lu, Qinglin Peng, Wei Jiang, Jingli Shi, Yamei Zhang, He Chen, Guochun Wang
OBJECTIVE: To investigate the associations between anti-NXP-2 autoantibody levels and disease activity as well as calcinosis severity. METHODS: The serum levels of anti-NXP-2 autoantibodies were determined in 709 idiopathic inflammatory myopathies (IIMs) and also serially measured by an in-house enzyme-linked immunosorbent assay using recombinant MORC3. Patients with anti-NXP-2 autoantibodies were divided into two subgroups: with or without calcinosis. The associations of anti-NXP-2 autoantibody levels with organ-specific disease activity, serum creatine kinase (CK) levels, and calcinosis severity were investigated in cross-sectional and longitudinal analyses...
March 13, 2018: Arthritis & Rheumatology
Yanhua Hu, Julie A Carman, Deborah Holloway, Selena Kansal, Li Fan, Christine Goldstine, Deborah Lee, John E Somerville, Robert Latek, Robert Townsend, Alyssa Johnsen, Sean Connolly, Somnath Bandyopadhyay, Nancy Shadick, Michael E Weinblatt, Richard Furie, Steven G Nadler
OBJECTIVE: To develop an objective, readily measurable pharmacodynamic biomarker of glucocorticoid (GC) activity. METHODS: Genes modulated by prednisolone were identified from in vitro studies using peripheral blood mononuclear cells from normal healthy volunteers (NHVs). Using the criteria of a >2-fold change relative to vehicle controls and an adjusted P value cutoff of <0.05, 64 upregulated and 18 downregulated genes were identified. A composite score of the upregulated genes was generated using a single-sample gene set enrichment analysis algorithm...
March 13, 2018: Arthritis & Rheumatology
Armin Rashidi, Stephen I Fisher
A 24-year-old woman with a history of systemic lupus erythematosus (SLE) presented with fever, polyarthralgia, and worsened neutropenia (0.5 x 109 /L). Her physical exam and other routine laboratory work up were unremarkable. Examination of a peripheral blood smear showed neutrophils (red arrows, A-C) engulfing homogenous, violaceus nuclear material (yellow arrows, A-C), confirming a suspected diagnosis of lupus flare. SLE-associated antinuclear antibodies opsonize nucleoproteins released from dying cells, with uptake by phagocytic cells, including polymorphonuclear leukocytes and macrophages, the so-called Lupus Erythematosus (LE) cells...
March 13, 2018: Arthritis & Rheumatology
Gwenny M Verstappen, Uzma Nakshbandi, Esther Mossel, Erlin A Haacke, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frans G M Kroese
We read with great interest the article by Fonseca et al (1), that was published in a recent issue of Arthritis & Rheumatology. The authors elegantly showed that T follicular regulatory (Tfr) cells were enriched in blood as well as in matched minor salivary gland (MSG) biopsies from patients with primary Sjögren's syndrome (pSS). They also showed that the Tfr/Tfh ratio in blood was increased in pSS compared to non-SS sicca patients. Interestingly, this Tfr/Tfh ratio in blood correlated with ectopic lymphoid structure formation in MSG tissue...
March 13, 2018: Arthritis & Rheumatology
Widian K Jubair, Jason D Hendrickson, Erin L Severs, Hanna M Schulz, Sumitra Adhikari, Diana Ir, Jose Pagan, Robert Anthony, Charles E Robertson, Daniel N Frank, Nirmal K Banda, Kristine A Kuhn
OBJECTIVE: Observations of microbial dysbiosis in patients with RA have raised interest in studying microbial-mucosal interactions as a potential trigger of RA. Using the murine collagen-induced arthritis (CIA) model, we hypothesized that microbiota modulate immune responses leading to autoimmune arthritis. METHODS: CIA was induced by immunization of mice with type II collagen (CII) in adjuvant on days 0 and 21, with arthritis appearing at days 23-24. Intestinal microbiota were profiled by 16S rRNA sequencing every 7 days during the course of CIA, and intestinal mucosal changes evaluated on days 14 and 35...
March 13, 2018: Arthritis & Rheumatology
Valter R Fonseca, Vasco C Romão, Ana Agua-Doce, João Eurico Fonseca, Luis Graca
We are excited to find that most of our conclusions (1) were replicated in an independent larger primary Sjögren's syndrome (pSS) cohort, as reported by Verstappen et al in their Letter (Verstappen G et al, Arthritis & Rheumatology, in press). Indeed, our colleagues were also able to demonstrate that the ratio of blood T follicular regulatory (Tfr) / T follicular helper (Tfh) cells were increased in pSS patients, and specifically within pSS patients with focus score (FS) ≥ 1, supporting its discriminative value for the diagnosis of pSS...
March 13, 2018: Arthritis & Rheumatology
Désirée van der Heijde, David I Daikh, Neil Betteridge, Gerd R Burmester, Afton L Hassett, Eric L Matteson, Ronald van Vollenhoven, Sharad Lakhanpal
A European League Against Rheumatism-American College of Rheumatology working group consisting of practicing and academic rheumatologists, a rheumatology researcher, and a patient representative created a succinct general statement describing rheumatic and musculoskeletal diseases (RMDs) in adults and children in language that can be used in conversations with the lay public, media, healthcare providers, and other stakeholders. Based on the literature review, several elements were deemed important for inclusion in the description of RMDs...
March 13, 2018: Arthritis & Rheumatology
Sultana Monira Hussain, Yuanyuan Wang, Graham G Giles, Stephen Graves, Anita E Wluka, Flavia M Cicuttini
OBJECTIVES: To examine the associations of female reproductive and hormonal factors with incidence of total knee arthroplasty (TKA) for osteoarthritis, and whether the associations differ according to overweight/obesity status. DESIGN: This study included 22,289 women in the Melbourne Collaborative Cohort Study. Data on age at menarche, pregnancy, parity, years of menstruation, oral contraceptive pill (OCP), menopausal status and hormone replacement therapy (HRT) were collected in 1990-1994...
March 7, 2018: Arthritis & Rheumatology
Santos Castañeda, Lorenzo Cavagna, Miguel A González-Gay
We have read with interest the report on the 2017 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups" by Lundberg et al (1,2). These criteria represent an important advance in the classification of adult and juvenile idiopathic inflammatory myositis (IIMs), allowing the classification of IIMs in definite (probability cutoff ≥90%), probable (probability ≥55%), possible (probability ≥50% but <55%) and improbable/disposable (probability <50%), depending on the score reached by adding the selected variables (1,2)...
March 7, 2018: Arthritis & Rheumatology
Anne-Mieke J W Haasnoot, Marco W Schilham, Sylvia Kamphuis, Petra C E Hissink Muller, Arnd Heiligenhaus, Dirk Foell, Kirsten Minden, Roel A Ophoff, Timothy R D J Radstake, Anneke I Den Hollander, Tjitske H C M Reinards, Sanne Hiddingh, Nicoline E Schalij-Delfos, Esther P A H Hoppenreijs, Marion A J van Rossum, Carine Wouters, Rotraud K Saurenmann, J Merlijn van den Berg, Nico M Wulffraat, Rebecca Ten Cate, Joke H de Boer, Sara L Pulit, Jonas J W Kuiper
OBJECTIVES: Uveitis is a visually-debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. To identify genetic susceptibility loci for uveitis in JIA, we conducted a genome-wide association study totalling 522 JIA cases. METHODS: We genotyped two cohorts of JIA patients with ophthalmological follow-up and then imputed the data using a genome-wide imputation reference panel, and an HLA-specific reference panel used for imputing amino acids and HLA types in the major histocompatibility complex (MHC)...
March 7, 2018: Arthritis & Rheumatology
Isabel Lopez-Oliva, Akshay D Paropkari, Shweta Saraswat, Stefan Serban, Zehra Yonel, Praveen Sharma, Paola de Pablo, Karim Raza, Andrew Filer, Iain Chapple, Thomas Dietrich, Melissa M Grant, Purnima S Kumar
OBJECTIVES: Studies that demonstrate an association between rheumatoid arthritis (RA) and dysbiotic oral microbiomes are often confounded by the presence of extensive periodontitis in these individuals. Therefore, the present investigation sought to investigate the role of RA in modulating the periodontal microbiome by comparing periodontally healthy individuals with and without RA. METHODS: Subgingival plaque was collected from was collected periodontally healthy individuals (22 with and 19 without RA), and 16S gene sequenced on the Ilumina MiSeq platform...
March 7, 2018: Arthritis & Rheumatology
Brian W Coburn, Kaleb Michaud, Debra A Bergman, Ted R Mikuls
OBJECTIVES: Observational data suggests that hyperuricemia and gout are associated with increased mortality while allopurinol use is associated with reduced mortality. There may also be a dose-dependent protective effect. Our objective was to determine whether dose escalation is associated with cause-specific mortality. METHODS: In this 10-year observational, active-comparator study of U.S. Veterans with gout initiating allopurinol, we used propensity score matching with Cox proportional hazards and competing risks regression to assess cause-specific mortality differences between allopurinol dose escalators versus non-escalators...
March 7, 2018: Arthritis & Rheumatology
John D Pauling, Lesley A Saketkoo, Robyn T Domsic
The recent report by Denton et al. [1] adds to previous well-designed negative placebo-controlled clinical trials of Raynaud's phenomenon (RP) in systemic sclerosis (SSc). The primary endpoint was the weekly average number of RP attacks, with secondary endpoints including daily RP attack duration and RP severity (the single-item Raynaud's Condition Score [RCS]), that together comprise the RCS diary. The accompanying editorial, provides insightful suppositions of factors contributing to the disappointing performance of the RCS diary in clinical trials [2]...
March 7, 2018: Arthritis & Rheumatology
Laurence E Cheng, Zahir Amoura, Benjamin Cheah, Falk Hiepe, Barbara A Sullivan, Lei Zhou, Gregory E Arnold, Wayne H Tsuji, Joan T Merrill, James B Chung
OBJECTIVE: Evaluate the safety and potential efficacy of AMG 557, a fully human antibody directed against the inducible T-cell costimulator ligand (ICOSL), in patients with systemic lupus erythematosus (SLE) with arthritis. METHODS: In this phase 1b, randomized, double-blind, placebo-controlled study, patients received AMG 557 210 mg (n=10) or placebo (n=10) weekly for 3 weeks, then every other week for 10 additional doses. Corticosteroids were tapered to ≤7...
March 7, 2018: Arthritis & Rheumatology
Christopher P Denton, Ariane L Herrick
Pauling et al highlight some of the limitations of using the Raynaud's Condition Score (RCS) in clinical trials of Raynaud's phenomenon and the need for better patient reported outcome measures. They have explored this in a survey of patients with systemic sclerosis who completed the RCS and although the number of cases in the survey is small, and possibly not representative of a clinical trial population, the points raised are interesting.We acknowledge the difficulties of undertaking clinical trials in Raynaud's phenomenon...
March 7, 2018: Arthritis & Rheumatology
Cecilia Hagert, Outi Sareila, Tiina Kelkka, Kutty Selva Nandakumar, Mattias Collin, Bingze Xu, Simon Guérard, Johan Bäcklund, Sirpa Jalkanen, Rikard Holmdahl
OBJECTIVE: To develop a new chronic RA model which is driven by the innate immune system. METHOD: The injection of a cocktail of four monoclonal antibodies against collagen type II followed by intra-peritoneal injections of mannan (from Saccharomyces cerevisiae) on days 5 and 60 led to the development of chronic arthritis in B10.Q mice. The role of the innate versus the adaptive immune system in this arthritis model was investigated using genetically modified mouse strains...
March 7, 2018: Arthritis & Rheumatology
Janneke de Winter, Manouk de Hooge, Marleen van de Sande, Henriëtte de Jong, Lonneke van Hoeven, Anoek de Koning, Inger Jorid Berg, Roberta Ramonda, Dominique Baeten, Désirée van der Heijde, Angelique Weel, Robert Landewé
OBJECTIVE: To compare MRI of the sacroiliac joints (MRI-SI) of healthy, symptomless individuals and those with known mechanical strain acting upon SI joints to axial spondyloarthritis (axSpA) and chronic back pain (CBP) patients. METHODS: Three trained, calibrated and blinded readers randomly scored MRI-SI of 172 subjects: 47 healthy individuals without current/past back pain; 47 axSpA patients from the SPondyloArthritis Caught Early (SPACE) cohort (with a previously confirmed positive MRI-SI); 47 CBP controls (irrespective of MRI-SI results) from the SPACE cohort; 7 women with postpartum back pain; and 24 frequent runners...
March 7, 2018: Arthritis & Rheumatology
Aileen Y Chang, Liliana Encinales, Jeffrey M Bethony, Gary L Simon
Supported by the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR-001877). We would like to thank Mogami et. al., for sharing their experience with chikungunya virus in the Brazilian context, especially highlighting the possible utility of ultrasound during the sub-acute phase to identify severe or evolving cases of arthritis. Indeed, Doppler ultrasound may be an effective approach to identify patients that might benefit from treatment with disease modifying agents such as methotrexate during the sub-acute phase...
March 7, 2018: Arthritis & Rheumatology
Anna Tjärnlund, Matteo Bottai, Ingrid E Lundberg
We have with great interest read the letter titled "Comments on the "2017 EULAR/ACR Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups". Points of concern", by Dr Castañeda et al published in your journal [1]. The authors discuss the antisynthetase syndrome (ASSD), a condition characterized by myositis, arthritis, interstitial lung disease (ILD), Raynaud's phenomenon and the presence of autoantibodies targeting aminoacyl transfer RNA synthetases, and the fact that this group was not included in the 2017 EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups [2]...
March 7, 2018: Arthritis & Rheumatology
Roberto Mogami, Mirhelen M De Abreu, Flavio Sztajnbock, Ana C B Koifman, André de A Vieira, Rodrigo S Torezani, Yêdda de F B Chagas, João L P Vaz
We read with interest the article Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study1 published in the December issue of this journal. We would like to congratulate the authors for their excellent work, a pioneer in the Americas with such a large cohort and accompanied by so much time. We recently performed a study2,3 with 50 patients with a confirmed diagnosis of chikungunya fever. The study was performed between 2016-2017 in the city of Rio de Janeiro, Brazil. In this work, ultrasonography was used to study the lesions on the wrists, hands and ankles...
March 7, 2018: Arthritis & Rheumatology
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