journal
MENU ▼
Read by QxMD icon Read
search

Arthritis & Rheumatology

journal
https://www.readbyqxmd.com/read/28086002/immune-array-analysis-in-sporadic-inclusion-body-myositis-reveals-hla-drb1-amino-acid-heterogeneity-across-the-myositis-spectrum
#1
Simon Rothwell, Robert G Cooper, Ingrid E Lundberg, Peter K Gregersen, Michael G Hanna, Pedro M Machado, Megan K Herbert, Ger J M Pruijn, James B Lilleker, Mark Roberts, John Bowes, Michael F Seldin, Jiri Vencovsky, Katalin Danko, Vidya Limaye, Albert Selva-O'Callaghan, Hazel Platt, Øyvind Molberg, Olivier Benveniste, Timothy R D J Radstake, Andrea Doria, Jan De Bleecker, Boel De Paepe, Christian Gieger, Thomas Meitinger, Juliane Winkelmann, Christopher I Amos, William E Ollier, Leonid Padyukov, Annette T Lee, Janine A Lamb, Hector Chinoy
OBJECTIVE: Inclusion body myositis (IBM) is characterised by a combination of inflammatory and degenerative changes affecting muscle. While the primary cause of IBM is unknown, genetic factors may influence disease susceptibility. We conducted the largest genetic association study to date in IBM, investigating immune-related genes using the Immunochip. METHODS: 252 Caucasian IBM cases were recruited from 11 countries through the Myositis Genetics Consortium (MYOGEN), and compared with 1,008 ethnically matched controls...
January 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28086001/a-reddish-finding-in-synovial-fluid-hematoidin
#2
Mariano Andrés, Eliseo Pascual
No abstract text is available yet for this article.
January 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28086000/a-dual-role-for-ucma-in-osteoarthritis-inhibition-of-aggrecanases-and-promotion-of-bone-turnover
#3
Michael Stock, Stefanie Menges, Nicole Eitzinger, Maria Geßlein, Renate Botschner, Laura Wormser, Alfiya Distler, Ursula Schlötzer-Schrehardt, Katharina Dietel, Jörg Distler, Christian Beyer, Kolja Gelse, Klaus Engelke, Marije I Koenders, Wim van den Berg, Klaus von der Mark, Georg Schett
OBJECTIVE: Cartilage damage and subchondral bone changes are closely connected in osteoarthritis. How these processes are interlinked is however incompletely understood to date. Here, we investigate the mechanistic role of the cartilage-derived protein UCMA in osteoarthritis-related cartilage and bone changes. METHODS: UCMA expression was assessed in healthy and osteoarthritic human and mouse cartilage. DMM-induced osteoarthritis was performed in WT and Ucma-deficient mice analysing cartilage and bone changes...
January 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28085999/immune-related-adverse-events-with-the-use-of-checkpoint-inhibitors-for-immunotherapy-of-cancer
#4
REVIEW
Maria E Suarez-Almazor, Sang T Kim, Noha Abdel-Wahab, Adi Diab
No abstract text is available yet for this article.
January 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28076903/slamf7-engagement-restores-defective-effector-cd8-t-cells-activity-in-response-to-foreign-antigens-in-systemic-lupus-erythematosus
#5
Denis Comte, Maria P Karampetsou, Nobuya Yoshida, Katalin Kis-Toth, Vasileios C Kyttaris, George C Tsokos
OBJECTIVE: Effector CD8+ T cell function is impaired in SLE and associated with compromised ability to fight infections. SLAMF7 engagement has been shown to enhance NK cell degranulation. Thus, we characterized the expression and function of SLAMF7 on CD8+ T cells subsets isolated from peripheral blood of SLE patients and healthy subjects. METHODS: CD8+ T cell subset distribution, SLAMF7 expression and cytolytic enzyme expression (perforin, GzmA, GzmB) were monitored on cells isolated from SLE patients and healthy controls by flow cytometry...
January 11, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28076899/genome-wide-association-analysis-reveals-genetic-heterogeneity-of-sj%C3%A3-gren-s-syndrome-according-to-ancestry
#6
Kimberly E Taylor, Quenna Wong, David M Levine, Caitlin McHugh, Cathy Laurie, Kimberly Doheny, Mi Y Lam, Alan N Baer, Stephen Challacombe, Hector Lanfranchi, Morten Schiødt, M Srinivasan, Hisanori Umehara, Frederick B Vivino, Yan Zhao, Stephen Shiboski, Troy E Daniels, John S Greenspan, Caroline H Shiboski, Lindsey A Criswell
OBJECTIVE: Sjögren's Syndrome (SS) is a systemic autoimmune disease affecting primarily the lacrimal and salivary glands. The Sjögren's International Collaborative Clinical Alliance (SICCA) is an international multisite observational study whose participants have been genotyped on the Omni 2.5M platform and undergone deep phenotyping using common protocol-directed methods, providing a unique opportunity to examine the genetic etiology of SS across ancestry and disease subsets. METHODS: We perform GWAS analyses utilizing dbGaP controls on all subjects (1405 cases, 1622 SICCA controls, 3125 external controls), European (similarly 585, 966, 2580), and Asian (similarly 460, 224, 901) with ancestry adjustments via principal component analyses...
January 11, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28076897/microrna-expression-shows-inflammatory-dysregulation-and-tumor-like-proliferative-responses-in-joints-of-patients-with-post-infectious-lyme-arthritis
#7
Robert B Lochhead, Klemen Strle, Nancy D Kim, Minna J Kohler, Sheila L Arvikar, John M Aversa, Allen C Steere
OBJECTIVE: Lyme arthritis (LA) is caused by infection with Borrelia burgdorferi and usually resolves following spirochetal killing with antibiotics. However, in some patients, arthritis persists after antibiotic therapy. To provide insights into underlying pathogenic processes associated with post-infectious LA, we analyzed differences in microRNA expression between LA patients with active infection compared with those with post-infectious LA. METHODS: MicroRNA expression was assayed in synovial fluid (SF) from LA patients before and after oral and IV antibiotic therapy, and from synovial tissue from post-infectious LA patients obtained months after antibiotic therapy...
January 11, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029757/identification-of-functional-and-expression-polymorphisms-associated-with-risk-for-anti-neutrophil-cytoplasmic-autoantibody-associated-vasculitis
#8
Peter A Merkel, Gang Xie, Paul A Monach, Xuemei Ji, Dominic J Ciavatta, Jinyoung Byun, Benjamin D Pinder, Ai Zhao, Jinyi Zhang, Yohannes Tadesse, David Qian, Matthew Weirauch, Rajan Nair, Alex Tsoi, Christian Pagnoux, Simon Carette, Sharon Chung, David Cuthbertson, John C Davis, Paul F Dellaripa, Lindsy Forbess, Ora Gewurz-Singer, Gary S Hoffman, Nader Khalidi, Curry Koening, Carol A Langford, Alfred D Mahr, Carol McAlear, Larry Moreland, E Philip Seo, Ulrich Specks, Robert F Spiera, Antoine Sreih, E William St Clair, John H Stone, Steven R Ytterberg, James T Elder, Jia Qu, Toshiki Ochi, Naoto Hirano, Jeffrey C Edberg, Ronald J Falk, Christopher I Amos, Katherine A Siminovitch
OBJECTIVE: To identify risk alleles relevant to the cause and biology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: We conducted a genome-wide association and subsequent replication study including 1986 cases of AAV [granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)] and 4723 controls. Meta-analysis of these datasets and functional annotation of identified risk loci were performed and candidate disease variants with unknown functional effects investigated for impact on gene expression and/or protein function...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029752/effects-of-baricitinib-on-lipid-apolipoprotein-and-lipoprotein-particle-profiles-in-a-phase-2b-study-in-patients-with-active-rheumatoid-arthritis
#9
Joel Kremer, Mark C Genovese, Edward Keystone, Peter C Taylor, Steven H Zuckerman, Giacomo Ruotolo, Douglas E Schlichting, Victoria L Crotzer, Eric Nantz, Scott D Beattie, William L Macias
Objective To assess the effects of baricitinib on lipid profile in patients with moderate-to-severe rheumatoid arthritis. Methods Once-daily baricitinib (1, 2, 4, or 8-mg) or placebo was studied in 301 randomized patients. Changes in lipid profile, particle size, and number were assessed at weeks 12/24; associations with clinical efficacy were evaluated. Apolipoproteins were assessed at weeks 4/12 for the placebo, and 4- and 8-mg baricitinib groups. Results Baricitinib treatment resulted in dose-dependent increases by week 12 in serum lipids (low-density lipoprotein cholesterol [LDL-C]: 3...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029751/the-effect-of-continuous-b-cell-depletion-with-rituximab-on-pathogenic-autoantibodies-and-total-igg-levels-in-anca-vasculitis
#10
Frank B Cortazar, William F Pendergraft, Julia Wenger, Charles T Owens, Karen Laliberte, John L Niles
OBJECTIVE: To evaluate the effect of rituximab on pathogenic autoantibodies and total immunoglobulin levels, and to identify serious adverse events, in patients with ANCA vasculitis treated with continuous B cell depletion. METHODS: We conducted a retrospective analysis of 239 patients with ANCA vasculitis treated with rituximab-induced continuous B cell depletion. Two treatment cohorts were analyzed: an induction group (n= 53) and a maintenance group (n=237). The change in ANCA titers and total immunoglobulin levels over time were evaluated using mixed-effects models...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029749/2016-annual-meeting-presidential-address
#11
Joan Von Feldt
No abstract text is available yet for this article.
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029745/early-mortality-in-a-multinational-systemic-sclerosis-inception-cohort
#12
Yanjie Hao, Marie Hudson, Murray Baron, Patricia Carreira, Wendy Stevens, Candice Rabusa, Solene Tatibouet, Loreto Carmona, Beatriz E Joven, Molla Huq, Susanna Proudman, Mandana Nikpour
OBJECTIVE: To determine mortality and causes of death in a multinational inception systemic sclerosis (SSc) cohort. METHODS: We quantified mortality as Standardized Mortality Ratio (SMR), Years of Life Lost (YLL) and percentage mortality in the first decade of disease. The inception cohort was comprised of patients recruited within 4 years of disease onset. For comparison, we used a prevalent cohort, which included all patients irrespective of disease duration at recruitment...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029744/high-titer-rheumatoid-arthritis-antibodies-preferentially-bind-fibrinogen-citrullinated-by-peptidyl-arginine-deiminase-4
#13
Nathalie E Blachère, Salina Parveen, Mayu O Frank, Brian D Dill, Henrik Molina, Dana E Orange
OBJECTIVE: Most patients with rheumatoid arthritis (RA) harbor antibodies to citrullinated autoantigens, such as citrullinated fibrinogen. Two isoforms of peptidyl arginine deiminase (PAD), PAD2 and PAD4, which catalyze citrullination with different substrate specificities, can be detected in RA synovium. This study was undertaken to determine whether RA patient antibodies preferentially bind PAD2 or PAD4 citrullinated fibrinogen. METHODS: RA patient and normal donor plasma was tested for binding to PAD2 or PAD4 citrullinated fibrinogen, native fibrinogen, or citrullinated fibrinogen peptides in various dilutions by ELISA and Western blot...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029742/functional-interaction-of-erap2-and-hla-b27-activates-the-unfolded-protein-response
#14
Zhenbo Zhang, Francesco Ciccia, Fanxing Zeng, Giuliana Guggino, Kirby Yee, Hasan Abdullah, Mark S Silverberg, Riccardo Alessandro, Giovanni Triolo, Nigil Haroon
OBJECTIVES: The basic mechanisms underlying ankylosing spondylitis (AS) pathogenesis remain unresolved. We previously reported an association of the single nucleotide polymorphisms (SNP) rs2549782 in Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with AS. It is known that patients homozygous for the G allele (GG) of another ERAP2 SNP rs2248374 have no ERAP2 expression (ERAP2-null). We utilized this information to study the impact of ERAP2 deficiency on HLA-B27 expression in AS patients...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28002891/response-to-the-letter-by-van-der-linden-and-khan
#15
LETTER
Janneke de Winter, Marleen van de Sande, Robert Landewé, Dominique Baeten
No abstract text is available yet for this article.
December 21, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28002890/do-not-let-gout-apathy-lead-to-gouty-arthropathy
#16
EDITORIAL
John D FitzGerald, Tuhina Neogi, Hyon K Choi
No abstract text is available yet for this article.
December 21, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28002888/discovery-of-t-cell-receptor-beta-motifs-specific-to-hla-b27-ankylosing-spondylitis-by-deep-repertoire-sequence-analysis
#17
Malek Faham, Victoria Carlton, Martin Moorhead, Jianbiao Zheng, Mark Klinger, Francois Pepin, Thomas Asbury, Marissa Vignali, Ryan O Emerson, Harlan S Robins, James Ireland, Emily Baechler-Gillespie, Robert D Inman
OBJECTIVE: Ankylosing spondylitis (AS), a chronic inflammatory disorder, has a striking association with HLA-B27. One hypothesis suggests that a common antigen that binds to HLA-B27 is important for AS disease pathogenesis. We utilized T-cell repertoire next-generation sequencing to determine sequences and motifs that are shared among HLA-B27 positive (B27(+) ) AS patients. METHODS: To identify motifs enriched among B27(+) AS patients, we performed T-cell receptor beta (TCRβ) repertoire sequencing from 191 B27(+) AS patients, 43 B27(neg) AS patients and 227 controls, and we obtained >77 million TCRβ clonotype sequences...
December 21, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28002885/axial-spondyloarthritis-in-relatives-of-probands-with-ankylosing-spondylitis-comment-on-the-article-by-turina-et-al
#18
LETTER
Sjef van der Linden, Muhammad A Khan
No abstract text is available yet for this article.
December 21, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27992709/reply-to-dr-olmedo-garz%C3%A3-n
#19
LETTER
Bodil Arnbak, Anne Grethe Jurik, Claus Manniche, Tue Secher Jensen
No abstract text is available yet for this article.
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27992708/revised-reply-to-letter-to-the-editor-with-regards-to-manuscript-ar-15-1750-r1
#20
LETTER
Roy Fleischmann, Sean E Connolly, Michael A Maldonado, Michael Schiff
No abstract text is available yet for this article.
December 19, 2016: Arthritis & Rheumatology
journal
journal
48327
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"