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Arthritis & Rheumatology

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https://www.readbyqxmd.com/read/28334504/redd1-deficiency-impairs-autophagy-and-mitochondrial-biogenesis-in-articular-cartilage-and-increases-the-severity-of-experimental-osteoarthritis
#1
Oscar Alvarez-Garcia, Tokio Matsuzaki, Merissa Olmer, Lars Plate, Jeffery W Kelly, Martin K Lotz
Objective REDD1 is an endogenous inhibitor of mTOR that regulates cellular stress responses. REDD1 expression is decreased in aged and osteoarthritis (OA) cartilage and it regulates mTOR signaling and autophagy in articular chondrocytes in vitro. The present study investigated the effects of REDD1 deletion in vivo using a mouse model of experimental OA. Methods Severity of OA was histologically assessed in 4-month-old wild-type and in Redd1(-/-) mice subjected to surgical destabilization of the medial meniscus (DMM)...
March 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28324917/abatacept-as-an-adjunctive-therapy-for-the-treatment-of-giant-cell-arteritis-comment-on-the-article-by-langford-et-al
#2
LETTER
Hubert de Boysson, Achille Aouba
No abstract text is available yet for this article.
March 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28324916/personalized-biologic-therapy-for-large-vessel-vasculitis
#3
LETTER
Sergey Moiseev, Pavel Novikov, Ilya Smitienko
No abstract text is available yet for this article.
March 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28324914/response-to-the-letter-to-the-editor-by-de-boysson-et-al-and-moiseev-et-al
#4
LETTER
Carol A Langford, Jeffrey P Krischer, Peter A Merkel
No abstract text is available yet for this article.
March 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28324912/gouty-tophus-as-an-unusual-cause-of-talus-fracture
#5
Steven Thomson, Stefan Urbanski, Paul MacMullan
No abstract text is available yet for this article.
March 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28320059/effects-of-treadmill-exercise-on-advanced-osteoarthritis-pain-in-rats
#6
Joshua Allen, Ian Imbert, Joshua Havelin, Terry Henderson, Glenn Stevenson, Lucy Liaw, Tamara King
OBJECTIVE: Exercise is commonly recommended for patients with osteoarthritis (OA) pain. However, whether exercise is beneficial in ameliorating persistent NSAID-resistant ongoing pain associated with advanced OA is unknown. METHODS: Rats treated with intra-articular monosodium iodoacetate (MIA) or saline underwent treadmill exercise or remained sedentary starting 10 days post-injection. Tactile sensory thresholds and weight bearing were assessed followed by radiographs at weekly intervals...
March 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28320058/regional-differences-between-perisynovial-and-infrapatellar-adipose-tissue-depots-and-their-response-to-class-ii-and-iii-obesity-in-patients-with-oa
#7
Natalia S Harasymowicz, Nick D Clement, Asim Azfer, Richard Burnett, Donald M Salter, A Hamish W R Simpson
OBJECTIVE: Obesity is associated with an increased risk of developing Osteoarthritis (OA), which is postulated to be secondary to inflammation from adipose tissue (AT). There are peri-articular adipose depots in synovial joints, the association of this tissue with OA has not been extensively explored. The aim of this study was to investigate differences in local AT depots in knees with OA and changes related to class II and III obesity. METHODS: Synovium and the infrapatellar fat pad (IPFP) were collected during total knee replacement from 69 patients with end-stage OA...
March 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28296337/anti-carbamylated-protein-antibodies-in-rheumatoid-arthritis-patients-are-reactive-to-specific-epitopes-of-the-human-fibrinogen-%C3%AE-chain
#8
Jonathan D Jones, B JoNell Hamilton, William F C Rigby
OBJECTIVE: Anti-carbamylated protein antibodies (ACarPA) are associated with rheumatoid arthritis (RA) risk and severity and are primarily directed against fibrinogen. The lack of understanding of ACarPA reactivity has limited analysis of their immunopathogenic associations in RA. To address this shortcoming, we mapped ACarPA epitope reactivity in RA patient sera. METHODS: Immunoblotting identified a patient serum with specific reactivity to carbamylated human fibrinogen β-chain...
March 15, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28296284/pro-inflammatory-cytokine-environments-can-drive-il-17-over-expression-by-%C3%AE-%C3%AE-t-cells-in-systemic-juvenile-idiopathic-arthritis
#9
Christoph Kessel, Katrin Lippitz, Toni Weinhage, Claas Hinze, Helmut Wittkowski, Dirk Holzinger, Ndate Fall, Alexei A Grom, Niklas Gruen, Dirk Foell
OBJECTIVE: Systemic-onset juvenile idiopathic arthritis (sJIA) is speculated to follow a biphasic course with an initial systemic disease phase driven by innate immune mechanisms and interleukin (IL)-1β as a key cytokine, while a second chronic arthritic phase may be dominated by adaptive immunity and cytokines such as IL-17A. Although a recent mouse model points to a critical role of IL-17 expressing γδT cells in disease pathology, in human patients both the prevalence of IL-17 as well as the role of producing cells are still unclear...
March 15, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28296257/randomized-controlled-trial-of-rituximab-and-cost-effectiveness-analysis-in-treating-fatigue-and-oral-dryness-in-primary-sjogren-s-syndrome
#10
Simon J Bowman, Colin C Everett, John L O'Dwyer, Paul Emery, Costantino Pitzalis, Wan-Fai Ng, Colin T Pease, Elizabeth J Price, Nurhan Sutcliffe, Nagui St Gendi, Frances C Hall, Sharon P Ruddock, Catherine Fernandez, Catherine Reynolds, Claire T Hulme, Kevin A Davies, Christopher J Edwards, Peter C Lanyon, Robert J Moots, Euthalia Roussou, Ian P Giles, Linda D Sharples, Michele Bombardieri
OBJECTIVE: We investigated whether rituximab, an anti-B-cell therapy, improved symptoms of fatigue and oral dryness in patients with Primary Sjögren's Syndrome (PSS). METHODS: Multicentre, randomised, double-blind, parallel-group placebo-controlled trial, including Health Economic Analysis. Anti-Ro positive patients with PSS, symptomatic fatigue and oral dryness were recruited from 25 UK rheumatology clinics from August 2011 to January 2014. Patients were centrally-randomised to either placebo IV or rituximab IV (1000mg in 250mL) at weeks 0, 2, 24 and 26, with pre-and post-infusion medication including corticosteroids...
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28296253/rituximab-in-the-treatment-of-sj%C3%A3-gren-s-syndrome-is-it-the-wrong-drug
#11
EDITORIAL
Hendrika Bootsma, Frans G M Kroese, Arjan Vissink
No abstract text is available yet for this article.
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28294573/interventions-for-cartilage-disease-current-state-of-the-art-and-emerging-technologies
#12
REVIEW
L F Ambra, L de Girolamo, B Mosier, A H Gomoll
No abstract text is available yet for this article.
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28294571/black-esophagus-in-antiphospholipid-syndrome
#13
Amrita Padda, Amar Mandalia, Amr H Sawalha
No abstract text is available yet for this article.
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28267901/-weighing-in-on-framingham-oa-measuring-biomechanical-and-metabolic-contributions-to-osteoarthritis
#14
EDITORIAL
C Thomas Appleton, Gillian A Hawker, Catherine L Hill, Janet E Pope
No abstract text is available yet for this article.
March 7, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28257605/authors-response-to-tezcan-and-colleagues-letter-to-the-editor
#15
LETTER
Claudio Vitali, Hal Scofield, Stephen C Shiboski, Raphaèle Seror, Lindsey A Criswell, Marc Labetoulle, Thomas M Lietman, Astrid Rasmussen, Simon J Bowman, Xavier Mariette, Caroline H Shiboski
No abstract text is available yet for this article.
March 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28257604/the-metabolic-syndrome-its-components-and-knee-osteoarthritis-oa-the-framingham-oa-study
#16
Jingbo Niu, Margaret Clancy, Piran Aliabadi, Vasan Ramachandran, David T Felson
OBJECTIVES: Studies have suggested that Metabolic Syndrome (MetS) is associated with osteoarthritis (OA). However, analyses have often not adjusted for BMI and have not explored whether levels of individual MetS components are related to OA. METHODS: Framingham Study subjects were assessed for OA in 1992-95 and again in 2002-05. Near the baseline visit, subjects had components of the MetS assessed. We defined incident radiographic OA (ROA) as present when a knee without ROA developed Kellgren and Lawrence grade ≥2 at follow-up and defined incident symptomatic OA (SxOA) as present when a knee developed the new combination of ROA and knee pain...
March 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28257603/arytenoid-chondritis
#17
Yasuhiro Suyama, Shin-Ichi Ishimoto, Kiyofumi Hagiwara
No abstract text is available yet for this article.
March 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28257602/the-biomarkers-of-lupus-disease-study-a-bold-approach-may-mitigate-interference-of-background-immunosuppressants-in-clinical-trials
#18
Joan T Merrill, Fred Immermann, Maryann Whitley, Tianhui Zhou, Andrew Hill, Margot O'Toole, Padmalatha Reddy, Marek Honczarenko, Aikaterini Thanou, Joe Rawdon, Joel M Guthridge, Judith A James, Sudhakar Sridharan
OBJECTIVES: Molecular medicine raised expectations for strategically targeted biologics in systemic lupus erythematosus (SLE), but clinical trials have been disappointing and difficult to interpret. Most studies add investigational agents to various, often effective, standard of care (SoC) immunosuppressants used at baseline, with unknown treatment interactions. Eliminating polypharmacy in trials of active lupus patients remains controversial. The BOLD study tested immunosuppressant withdrawal as a novel approach to interpretable SLE trials...
March 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28245351/choosing-new-targets-for-rheumatoid-arthritis-therapeutics-too-interesting-to-fail
#19
EDITORIAL
Iain B McInnes, Duncan Porter, Stefan Siebert
No abstract text is available yet for this article.
February 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28245350/cardiovascular-safety-of-tocilizumab-versus-tumor-necrosis-factor-inhibitors-in-patients-with-rheumatoid-arthritis-a-multi-database-cohort-study
#20
Seoyoung C Kim, Daniel H Solomon, James R Rogers, Sara Gale, Micki Klearman, Khaled Sarsour, Sebastian Schneeweiss
OBJECTIVE: While tocilizumab (TCZ) is known to increase LDL cholesterol, it is unclear whether TCZ increases cardiovascular (CV) risks in patients with rheumatoid arthritis (RA). METHODS: To examine comparative CV safety, we conducted a cohort study of RA patients who newly started TCZ or TNFi using claims data from Medicare, IMS PharMetrics and MarketScan. All patients were required to have previously used a different TNFi, abatacept, or tofacitinib. The primary outcome was a composite CV endpoint of hospitalization for myocardial infarction (MI) or stroke...
February 28, 2017: Arthritis & Rheumatology
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