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Arthritis & Rheumatology

Andrea L Roberts, Susan Malspeis, Laura D Kubzansky, Candace H Feldman, Shun-Chiao Chang, Karestan C Koenen, Karen H Costenbader
OBJECTIVE: To conduct the first longitudinal study examining whether trauma exposure and PTSD are associated with increased risk of incident SLE in a civilian cohort. METHODS: We examined the association of trauma exposure and PTSD symptoms with SLE incidence over 24 years of follow-up in a U.S. longitudinal cohort of women (N=54,763). Incident SLE with ≥4 American College of Rheumatology criteria was ascertained by self-report and confirmed by medical record review...
September 20, 2017: Arthritis & Rheumatology
Katalin Mikecz
It is universally accepted that effective treatment of rheumatoid arthritis (RA) requires initiation of therapy at the early phase of articular inflammation. In addition to clinical and serological assessments, imaging of joint tissues provides useful information for the early diagnosis of RA (1). Although radiographic (X-ray) imaging can be used to detect bone erosions and to monitor disease progression in terms of bone involvement, X-ray does not detect early synovitis. This article is protected by copyright...
September 12, 2017: Arthritis & Rheumatology
Peter M Izmirly, Isabella Wan, Sara Sahl, Jill P Buyon, H Michael Belmont, Jane E Salmon, Anca Askanase, Joan M Bathon, Laura Geraldino-Pardilla, Yousaf Ali, Ellen M Ginzler, Chaim Putterman, Caroline Gordon, Charles G Helmick, Hilary Parton
OBJECTIVE: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of systemic lupus erythematosus (SLE) in 2007 and the incidence from 2007 to 2009 among residents of New York County (Manhattan), New York, and to characterize cases by race/ethnicity, including Asians and Hispanics, for whom data are lacking. METHODS: We identified possible SLE cases from hospital records, rheumatologist records, and administrative databases...
September 10, 2017: Arthritis & Rheumatology
Maria Dall'Era, Miriam G Cisternas, Kurt Snipes, Lisa J Herrinton, Caroline Gordon, Charles G Helmick
OBJECTIVE: Estimates of the incidence and prevalence of systemic lupus erythematosus (SLE) in the US have varied widely. The purpose of this study was to conduct the California Lupus Surveillance Project (CLSP) to determine credible estimates of SLE incidence and prevalence, with a special focus on Hispanics and Asians. METHODS: The CLSP, which is funded by the Centers for Disease Control and Prevention, is a population-based registry of individuals with SLE residing in San Francisco County, CA, from January 1, 2007 through December 31, 2009...
September 10, 2017: Arthritis & Rheumatology
Susan Manzi, Joan Merrill
No abstract text is available yet for this article.
September 10, 2017: Arthritis & Rheumatology
Cynthia S Crowson
Gwinnutt et al. reported a trend toward reduced mortality risk in the early treatment group and a significant reduction in mortality in the late treatment group compared to the never treated group among patients with rheumatoid arthritis.[1] In attempting to address an important question in rheumatology care regarding the "window of opportunity", whereby early treatment initiation may lead to improved outcomes, the analyses used in this report unfortunately fell prey to immortal time bias.[2] Immortal time bias refers to a time period during which patients could not have died by design...
September 7, 2017: Arthritis & Rheumatology
Uma Thanarajasingam, Mark A Jensen, Jessica M Dorschner, Theresa Wampler Muskardin, Yogita Ghodke-Puranik, Monica Purmalek, Elias Eliopoulos, Maria I Zervou, George N Goulielmos, Matthew Howard, Mariana J Kaplan, Timothy B Niewold
OBJECTIVE: We describe a 38-year-old woman presenting with a history of inflammatory arthritis, rash and daily fevers. She was noted to have chronic parvoviral infection with persistently detectable viral titers and a novel mutation in the ELANE gene. ELANE encodes neutrophil elastase, a neutrophil serine protease with important antimicrobial effects and is found as part of neutrophil extracellular trap (NET) complexes. Pathogenic ELANE mutations have been described in forms of hereditary neutropenia...
September 7, 2017: Arthritis & Rheumatology
Liron Caplan, Karen E Hansen, Kenneth G Saag
The American College of Physicians (ACP) recently updated their clinical practice guidelines for the treatment of low bone density and osteoporosis. These guidelines, aimed at generalists, importantly emphasize the critical nature of osteoporosis and provide a basic framework to guide its management. We support the ACP's effort to improve awareness and treatment of osteoporosis. However, we would like to address some important limitations encompassed by the six ACP recommendations that are particularly relevant to specialists, such as rheumatologists...
September 7, 2017: Arthritis & Rheumatology
Alvise Berti, Divi Cornec, Cynthia S Crowson, Ulrich Specks, Eric L Matteson
OBJECTIVE: To estimate the incidence, prevalence and mortality of ANCA-associated vasculitis (AAV) and its subsets, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic GPA (EGPA), in a U.S. based adult population. METHODS: All medical records of patients with a diagnosis or suspicion of AAV in Olmsted County, Minnesota from January 1, 1996 to December 31, 2015 were reviewed. Incidence rates were age- and sex-adjusted to the 2010 US white population...
September 7, 2017: Arthritis & Rheumatology
Brandon L Adler, Gene H Kim, Alexandra D Haden
The patient, a previously healthy 37-year-old man, presented with new onset erythematous ulcerating nodules within longstanding tattoos on the upper arms (A). He reported making homemade ink by crushing graphite pencil tips, and tattooing himself using unsterilized instruments. Lesions were mildly tender. This article is protected by copyright. All rights reserved.
September 7, 2017: Arthritis & Rheumatology
Cormac McCarthy, Carl Orr, Ursula Fearon, Douglas J Veale, Emer P Reeves, Noel G McElvaney
We thank Drs Hutchinson and Eggleton for their interest in our report and for raising some interesting points. While we believe there is some merit in the issues they raise, we do not believe these invalidate the data we have presented or the conclusions we made in our initial report. This article is protected by copyright. All rights reserved.
September 7, 2017: Arthritis & Rheumatology
David Hutchinson, Paul Eggleton
We read with interest the paper "Genetic variation of the alpha-1-antitrypsin (AT) gene is associated with increased autoantibody production in rheumatoid arthritis" by McCarthy et al. A strong association between mutant alpha-1-antitrypsin Z (ATZ) and ACPA production was noted in RA (1). The authors suggest that alpha-1-antitrypsin deficiency (ATD) may give rise to a tendency towards ACPA production. We suggest that it is the abnormal mutant protein ATZ itself that induces autophagy resulting in ACPA production in inflammatory cells such as macrophages rather than as a consequence of ATD per se...
September 7, 2017: Arthritis & Rheumatology
James M Gwinnutt, Deborah Pm Symmons, Mark Lunt, Suzanne Mm Verstappen
We thank Dr Crowson for her interest in our study and for her comment.(1,2) Immortal time bias is an important issue in observational research and can lead to large biases and misinterpretation of results. However, we would argue that in this instance, the bias is not large and the clinical message from our analysis has not changed. Immortal time leads to important bias when a large proportion of follow-up time in the exposed group is considered 'immortal'. This article is protected by copyright. All rights reserved...
September 7, 2017: Arthritis & Rheumatology
Marta Cossu, Lenny van Bon, Carlo Preti, Marzia Rossato, Lorenzo Beretta, Timothy R D J Radstake
OBJECTIVE: Definite systemic sclerosis patients lacking fibrotic features stratify in an intermediate severity stage between preclinical/early (EaSSc) and fibrotic subsets (limited and diffuse cutaneous [lcSSc, dcSSc]). We aimed to molecularly characterize non-fibrotic SSc and EaSSc on the basis of a broad panel of serum markers of inflammation and tissue damage to increase the knowledge of pathophysiologic mechanisms underlying SSc progression before development of fibrosis. METHODS: An 88-plex immunoassay was performed in sera from a discovery cohort composed of 21 EaSSc (LeRoy and Medsger criteria), 15 non-fibrotic SSc (2013 ACR/EULAR criteria without skin or lung fibrosis) and 11 HC...
August 31, 2017: Arthritis & Rheumatology
Natalia S Harasymowicz, Nick D Clement, Asim Azfer, Richard Burnett, Donald M Salter, Hamish Simpson
We thank Macchi et al. for their comments regarding our study describing regional differences between perisynovial and infrapatellar adipose tissue (AT) depots in patients with end stage osteoarthritis (OA) of the knee [1]. They summarize our findings concisely and contextualize this data with their own findings. The main goal of our paper was to quantify the differences between synovial and infrapatellar fat pad (IPFP) AT deposits from the same patient. The synovial AT had more pro-inflammatory/pro-fibrotic response than the IPFP in patients with obesity...
August 31, 2017: Arthritis & Rheumatology
Yogita Ghodke-Puranik, Jessica M Dorschner, Danielle M Vsetecka, Shreyasee Amin, Ashima Makol, Floranne Ernste, Thomas Osborn, Kevin Moder, Vaidehi Chowdhary, Elias Eliopoulos, Maria I Zervou, George N Goulielmos, Mark A Jensen, Timothy B Niewold
BACKGROUND: Systemic lupus erythematosus (SLE) is frequently characterized by type I interferon (IFN) pathway activation. We previously found a missense SNP in the purine nucleoside phosphorylase (PNP) gene was associated with high IFN in SLE (rs1049564, P=1.24 x10(-7) ). PNP is a key enzyme in purine metabolism. In this study, we perform functional follow-up of this polymorphism in human cells. METHODS: Type I IFN was measured in patient sera using a reporter cell assay...
August 31, 2017: Arthritis & Rheumatology
James R Seibold, Fredrick M Wigley
The peripheral vascular disease in systemic sclerosis (scleroderma) is a challenging problem because it presents with both vasospasm and an underlying structural vascular disease that leads not only to severe Raynaud phenomenon but often critical digital ischemia with progressive tissue damage or acute ulceration. While current therapy with a calcium channel blocker alone or combined with another vasodilating agent provides some modest benefit, it does not provide adequate control of Raynaud's events in many patients with scleroderma...
August 31, 2017: Arthritis & Rheumatology
Marie-Elise Truchetet, Stéphanie Dublanc, Thomas Barnetche, Olivier Vittecoq, Xavier Mariette, Christophe Richez, Patrick Blanco, Michael Mahler, Cécile Contin-Bordes, Thierry Schaeverbeke
OBJECTIVES: To assess the prevalence of anti-carbamylated protein (CarP) antibodies in a French cohort of early arthritis and to investigate their association with clinical features, final diagnosis, prognosis and comorbidities. METHODS: The presence of anti-CarP antibodies among patients with early arthritis belonging to the ESPOIR French cohort (n=720) was determined using ELISA. We calculated the prevalence of anti-CarP antibodies in different patient subgroups that were stratified according to their anti-citrullinated peptides antibodies (ACPA) and/or rheumatoid factor (RF) status...
August 29, 2017: Arthritis & Rheumatology
William F C Rigby, Sladjana Skopelja-Gardner, Jonathan D Jones
Arginine and lysine are distinguished by their identity as the most cationic (basic) amino acids. They are also the target of many post-translational modifications, e.g. acetylation, citrullination, hydroxylation, methylation, ubiquitination. These modifications are catalyzed by a series of enzymes, presumably to enable a tapestry of functionality by a single protein, including regulation of DNA transcription, repair and replication. Besides their functional roles in normal physiological conditions, some of these protein modifications have been recognized as inflammatory triggers and targets of autoimmune reactions...
August 29, 2017: Arthritis & Rheumatology
Bryant R England, Ted R Mikuls, Fenglong Xie, Shuo Yang, Lang Chen, Jeffrey R Curtis
OBJECTIVES: Histopathological studies have implicated herpes zoster (HZ) as a causative organism of giant cell arteritis (GCA). We assessed the epidemiologic association of HZ events with incident GCA. METHODS: We performed a retrospective cohort study utilizing two, large, independent US administrative datasets (Medicare 5% and Truven MarketScan) with eligible subjects having 12 months of continuous coverage, >50 years old, and without history of GCA or polymyalgia rheumatica...
August 29, 2017: Arthritis & Rheumatology
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