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Arthritis & Rheumatology

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https://www.readbyqxmd.com/read/29145713/positron-emission-tomography-as-an-imaging-biomarker-in-a-prospective-longitudinal-cohort-of-patients-with-large-vessel-vasculitis
#1
Peter C Grayson, Sara Alehashemi, Armin A Bagheri, Ali Cahid Civelek, Thomas R Cupps, Mariana J Kaplan, Ashkan A Malayeri, Peter A Merkel, Elaine Novakovich, David A Bluemke, Mark A Ahlman
OBJECTIVES: To assess the clinical value of (18) F-flurodeoxyglucose (FDG) positron emission tomography (PET) in a prospective cohort of patients with large-vessel vasculitis (LVV) and disease comparators. METHODS: Patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA) were studied, along with a comparator group consisting of patients with hyperlipidemia, diseases that mimic LVV, and healthy controls. Participants underwent clinical evaluation and FDG-PET imaging, and patients with LVV underwent serial imaging at six-month intervals...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145712/cartilage-microrna-dysregulation-during-the-onset-and-progression-of-mouse-osteoarthritis-is-independent-of-aggrecanolysis-and-overlaps-with-candidates-from-end-stage-human-disease
#2
Louise H W Kung, Varshini Ravi, Lynn Rowley, Constanza Angelucci, Amanda J Fosang, Katrina M Bell, Christopher B Little, John F Bateman
OBJECTIVE: To identify candidate microRNAs that potentially regulate the initiation and progression of osteoarthritis. METHODS: Osteoarthritis was induced in 10-12 week old male wild-type C57BL6 mice and in mice resistant to aggrecanase cleavage (Acan p.374ALGS→374NVYS) by destabilization of the medial meniscus (DMM). Osteoarthritis pathology was scored histologically. RNA from cartilage and subchondral bone were harvested in parallel by laser micro-dissection at 1 and 6 weeks post-surgery...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145709/defining-a-unified-vascular-phenotype-in-systemic-sclerosis
#3
REVIEW
Yannick Allanore, Oliver Distler, Marco Matucci-Cerinic, Christopher P Denton
Microcirculation impairment and related vasculopathy is a hallmark of systemic sclerosis. Digital ulcers are second only to Raynaud's phenomenon as a vascular complication occurring in scleroderma patients. Digital ulcers are painful and generate disability. Furthermore, patients may develop recurrent digital ulcers and one may ask whether the outcomes of such patients might be different to those of unaffected ones. Recently several registries have provided relevant information about digital ulcers. Male sex and severe skin disease seem to be the main associated factors observed in several registries...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145701/tnf-antagonists-killing-two-birds-with-one-biologic-stone
#4
EDITORIAL
Joan M Bathon, Jon T Giles, Daniel H Solomon
Forty years have passed since it was first recognized that patients with autoimmune rheumatic disease have an increased risk of fatal and non-fatal cardiovascular (CV) events (1) Although initial reports focused on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), similar findings were verified subsequently in patients with psoriasis (Ps) and/or psoriatic arthritis (PsA) and spondyloarthritis. An early feature of the atherosclerotic lesion is infiltration with inflammatory cells, particularly monocytes/macrophages, and the presence of these cells in mature plaque elevates the risk of plaque rupture and thrombosis (2)...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29136340/dermatological-addendum-to-the-2012-international-chapel-hill-consensus-conference-nomenclature-of-vasculitides
#5
Cord H Sunderkötter, Bernhard Zelger, Ko-Ron Chen, Luis Requena, Warren Piette, J Andrew Carlson, Jan Dutz, Peter Lamprecht, Alfred Mahr, Elisabeth Aberer, Victoria P Werth, David A Wetter, Seiji Kawana, Raashid Luqmani, Camille Frances, Joseph Jorizzo, J Richard Watts, Dieter Metze, Marzia Caproni, Erkan Alpsoy, Jeffrey P Callen, David Fiorentino, Peter A Merkel, Ronald J Falk, J Charles Jennette
OBJECTIVE: The objective of this project was to prepare a dermatologic addendum to the 2012 Chapel Hill consensus conference nomenclature to address vasculitides affecting the skin. The goal was to standardize names and definitions for cutaneous vasculitis. METHODS: A nominal group technique with a facilitator was used to reach a consensus using multiple face-to-face meetings, e-mail discussions, and teleconferences. RESULTS: Standardized names, definitions and descriptions are provided for cutaneous components of systemic vasculitides (e...
November 14, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29121457/drugs-implicated-in-systemic-autoimmunity-modulate-neutrophil-extracellular-trap-formation
#6
Jorge A Irizarry-Caro, Carmelo Carmona-Rivera, Daniella M Schwartz, Sami S Khaznadar, Mariana J Kaplan, Peter C Grayson
OBJECTIVE: Aberrant neutrophil extracellular trap (NET) formation has been implicated as a mechanism to induce auto-reactivity in at-risk individuals. The study objective was to assess whether medications implicated in cases of drug-induced autoimmunity (hydralazine and procainamide) and medications less commonly associated with drug-induced autoimmunity (minocycline and clozapine) induce NET formation and/or prevent NET degradation. METHODS: Human neutrophils were incubated with the drugs of interest and resultant NET formation was quantified by fluorescent microscopy...
November 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29121455/bench-to-bedside-and-back-again-finding-the-goldilocks-zone-within-the-scleroderma-universe
#7
EDITORIAL
Janet E Pope, Jason J Lee, Christopher P Denton
Systemic sclerosis (SSc) is a complex inflammatory connective tissue disease characterized by skin thickening, organ fibrosis and vasculopathy [1, 2]. The underlying disease mechanisms and pathophysiology are not fully understood. However, it appears to be, at least in part, driven by autoimmunity and inflammation associated with microvascular dysfunction ultimately resulting in excess extracellular matrix deposition in target organs [2-4]. Clinical heterogeneity coupled with our lack of understanding of the disease pathogenesis means that current treatment strategies are mostly organ based therapies using anti-rheumatic drugs that were originally approved for other indications [5]...
November 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29121454/the-innate-and-adaptive-immune-response-are-both-involved-in-drug-induced-autoimmunity
#8
EDITORIAL
Amr H Sawalha
Drug-induced autoimmunity is an intriguing phenomenon that has been described in the medical literature at least since 1945, with a report from the Medical Corps of the Army of the United States describing a case of systemic lupus erythematosus induced by sulfadiazine (1). While an autoantibody response in drug-induced autoimmunity is more universal, the spectrum of clinical autoimmunity is variable and likely influenced by host genetics including genetic variants predisposing to autoimmunity and genetic variants affecting drug metabolism...
November 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29108116/arthritis-in-melorheostosis-an-uncommon-feature-in-a-rare-disease
#9
Enrico Selvi, Marco Bardelli, Giacomo Maria Guidelli
A 53-year-old male developed left knee and left ankle arthritis associated with marked induration of the skin and soft tissues distal to the knees. The left knee was swollen, tender, and with a non-reducible contracture and similarly the left ankle and the subtalar joint were stiff and moderately swollen. In addition, diffuse, bluish, small vascular ectasia, hypertrichosis and skin pigmentation of the affected sites were evident (fig1). These symptoms began 20 years before and the patient had been diagnosed with eosinophilic fasciitis and treated with daily prednisone leading to partial improvement of the symptoms, but not of the knee deformity and soft tissue induration...
November 6, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29108114/reply-to-bigler-et%C3%A2-al-ar-17-1461
#10
Bryant R England, Ted R Mikuls, Jeffrey R Curtis
We thank Dr. Bigler and his colleagues for their interest in our article and sharing the results from their laboratory. The authors proposed evaluating a biologic mechanism linking Varicella Zoster Virus (VZV) to giant cell arteritis (GCA) through assessment of cross-reactive VZV-specific T cell immunity, hypothesizing that VZV reactive T-cells would be increased in GCA patients relative to controls. However, their in vitro results from a small sample of GCA and control (inflammatory and non-inflammatory) patients designed to test this hypothesis through the quantification of VZV specific T-cells and T-cell reactivity (in response to stimulation with a protein extract from an aortic specimen of a single GCA patient) found no significant differences between cases and controls...
November 6, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29108111/genetic-variants-in-erap1-and-erap2-associated-with-immune-mediated-diseases-influence-protein-expression-and-isoform-profile
#11
Aimee L Hanson, Thomas Cuddihy, Katelin Haynes, Dorothy Loo, Craig J Morton, Udo Oppermann, Paul Leo, Gethin P Thomas, Kim-Anh Lê Cao, Tony J Kenna, Matthew A Brown
OBJECTIVE: The endoplasmic reticulum aminopeptidases ERAP1 and ERAP2, encoded on chromosome 5q15, trim endogenous peptides for human leukocyte antigen (HLA) mediated presentation to the immune system. Polymorphisms in ERAP1 and/or ERAP2 are strongly associated with several immune-mediated diseases with specific HLA backgrounds, implicating altered peptide handling and presentation as a prerequisite for autoreactivity against an arthritogenic peptide. Given the thorough characterisation of disease risk-associated polymorphisms that alter ERAP activity, this study aimed instead to interrogate the expression effect of chromosome 5q15 polymorphisms to determine their effect on ERAP isoform and protein expression...
November 6, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29088583/emerging-treatment-models-in-rheumatology-igg4-related-disease-insights-into-human-immunology-and-targeted-therapies-comments-on-the-article-by-perugino-et-al
#12
LETTER
A Faiz Karim, Laura E M Eurelings, P Martin van Hagen, Jan A M van Laar
We read with great interest the published article by Perugino et al (1) providing an excellent overview on IgG4-related disease (IgG4-RD). However, the authors have not included the value of C-reactive protein (CRP) in IgG4-RD and the potential secondary complications due to this. Herewith, we want to highlight the clinical relevance of elevated CRP in IgG4-RD. This article is protected by copyright. All rights reserved.
October 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29088581/disease-damage-and-acute-phase-reactants-in-igg4-related-disease
#13
Cory A Perugino, John H Stone
We thank Dr. Karim and colleagues for their thoughtful comment on our paper [1], including their mention of a patient with longstanding IgG4-related disease (IgG4-RD) who developed secondary (AA) amyloidosis, presumably as a consequence of longstanding, untreated inflammation [2]. This article is protected by copyright. All rights reserved.
October 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29088580/tnf-%C3%AE-inhibitors-are-associated-with-reduced-indices-of-subclinical-atherosclerosis-in-patients-with-psoriatic-disease
#14
Lihi Eder, Aditya A Joshi, Amit K Dey, Richard Cook, Evan L Siegel, Dafna D Gladman, Nehal N Mehta
OBJECTIVES: We performed a two-stage study to assess the effect of TNF-α inhibitors (TNFi) on subclinical cardiovascular disease in psoriatic patients. METHODS: We first assessed carotid total plaque area by ultrasound at baseline and after 2-3 years in patients with psoriasis and psoriatic arthritis (PsA) (n=319). The annual progression rate of atherosclerosis was the outcome of interest. In stage 2 we studied vascular inflammation using FDG PET/CT in PsA patients on TNFi (n=21) and age and sex matched PsA patients not on any biologics (n=13)...
October 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29088579/phase-2b-trial-of-a-novel-extended-release-microsphere-formulation-of-triamcinolone-acetonide-for-intra-articular-injection%C3%A2-in-knee-osteoarthritis
#15
Philip G Conaghan, Stanley B Cohen, Francis Berenbaum, Joelle Lufkin, James R Johnson, Neil Bodick
OBJECTIVE: FX006 is a novel, microsphere-based, extended-release formulation of triamcinolone acetonide (TA) for intra-articular injection designed to maintain TA joint concentration and provide prolonged analgesic benefits in patients with osteoarthritis (OA) of the knee. The aim of this study was to compare the analgesic benefits of two FX006 doses with saline-placebo injection. METHODS: In this Phase 2b study, participants with knee OA (Kellgren-Lawrence Grade 2-3) and average daily pain (ADP)-intensity ≥5 to ≤9 (0-10 Numeric Rating Scale) were randomized (1:1:1) and received single IA injections of FX006 32 mg (N=104) or 16 mg (N=102) or saline-placebo (N=100)...
October 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29088578/varicella-zoster-virus-specific-t-cell-responses-in-untreated-giant-cell-arteritis
#16
LETTER
Marc B Bigler, Julia R Hirsiger, Mike Recher, Matthias Mehling, Thomas Daikeler, Christoph T Berger
Giant cell arteritis (GCA) is a large vessel vasculitis of unknown cause. Infections were long suspected as potential disease triggers, yet a disease causing pathogen has not been identified to date(1). Recently, several studies reported Varicella zoster virus (VZV) particles in artery biopsies(2). Alike other herpes viruses, VZV has a very high prevalence, remaining dormant in a latent stage controlled by the immune system. Loss of T cell-mediated viral control results in herpes zoster (or shingles). This article is protected by copyright...
October 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29084415/association-of-distinct-fine-specificities-of-anti-citrullinated-peptide-antibodies-with-elevated-immune-responses-to-prevotella-intermedia-in-a-subgroup-of-patients-with-rheumatoid-arthritis-and-periodontitis
#17
Anja Schwenzer, Anne-Marie Quirke, Anna M Marzeda, Alicia Wong, Anna B Montgomery, Harlan R Sayles, Sigrun Eick, Katarzyna Gawron, Maria Chomyszyn-Gajewska, Katarzyna Łazarz-Bartyzel, Simon Davis, Jan Potempa, Benedikt M Kessler, Roman Fischer, Patrick J Venables, Jeffrey B Payne, Ted R Mikuls, Kim S Midwood
OBJECTIVE: In addition to the long-established link with smoking, periodontitis (PD) is a risk factor for rheumatoid arthritis (RA). This study was undertaken to elucidate the mechanism by which PD could induce antibodies to citrullinated peptides (ACPAs), by examining the antibody response to a novel citrullinated peptide of cytokeratin 13 (CK-13) identified in gingival crevicular fluid (GCF), and comparing the response to 4 other citrullinated peptides in patients with RA who were well-characterized for PD and smoking...
October 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29106061/2017-european-league-against-rheumatism-american-college-of-rheumatology-classification-criteria-for-adult-and-juvenile-idiopathic-inflammatory-myopathies-and-their-major-subgroups
#18
Ingrid E Lundberg, Anna Tjärnlund, Matteo Bottai, Victoria P Werth, Clarissa Pilkington, Marianne de Visser, Lars Alfredsson, Anthony A Amato, Richard J Barohn, Matthew H Liang, Jasvinder A Singh, Rohit Aggarwal, Snjolaug Arnardottir, Hector Chinoy, Robert G Cooper, Katalin Dankó, Mazen M Dimachkie, Brian M Feldman, Ignacio Garcia-De La Torre, Patrick Gordon, Taichi Hayashi, James D Katz, Hitoshi Kohsaka, Peter A Lachenbruch, Bianca A Lang, Yuhui Li, Chester V Oddis, Marzena Olesinska, Ann M Reed, Lidia Rutkowska-Sak, Helga Sanner, Albert Selva-O'Callaghan, Yeong-Wook Song, Jiri Vencovsky, Steven R Ytterberg, Frederick W Miller, Lisa G Rider
OBJECTIVE: To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. METHODS: Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology, and pediatric clinics worldwide. Several statistical methods were utilized to derive the classification criteria. RESULTS: Based on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived...
October 27, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29073352/antigen-driven-lymphoproliferations-in-sj%C3%A3-gren-s-syndrome-patients-accumulate-in-complement-receptor-2-cd21-low-b-cells
#19
Salomé Glauzy, Marco Boccitto, Jason M Bannock, Fabien R Delmotte, David Saadoun, Patrice Cacoub, John A Ice, Kathy L Sivils, Judith A James, Sandra L Wolin, Eric Meffre
OBJECTIVE: Sjögren's Syndrome (SS) patients are prone to develop malignant lymphomas and a correlation has been established between lymphoproliferations and the presence in patients' blood of an unusual B cell population that downregulated complement receptor 2/CD21. We sought to determine from which B cell compartment lymphoproliferations in SS patients emerge and what are the mechanisms that promote these clonal B cell expansions. METHODS: Using a PCR-based approach that allows us to clone and express, in vitro, recombinant antibodies produced by single B cells, we tested the reactivity of antibodies expressed by CD19(+) CD10(-) CD27(-) IgM(+) CD21(-/low) cells from SS patients...
October 26, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29073351/belimumab-for-the-treatment-of-early-diffuse-systemic-sclerosis-results-of-a-randomized-double-blind-placebo-controlled-pilot-trial
#20
Jessica K Gordon, Viktor Martyanov, Jennifer M Franks, Elana J Bernstein, Jackie Szymonifka, Cynthia Magro, Horatio F Wildman, Tammara A Wood, Michael L Whitfield, Robert F Spiera
OBJECTIVE: To assess the safety and efficacy of treatment with belimumab in patients with early diffuse cutaneous systemic sclerosis (dcSSc) treated with background mycophenolate mofetil (MMF). METHODS: In this 52-week, investigator-initiated, single-center, double-blind, placebo-controlled, pilot study, 20 patients recently started on MMF were randomized 1:1 to additionally receive belimumab 10 mg/kg intravenously or placebo. We assessed safety, efficacy and differential gene expression (NCT01670565)...
October 26, 2017: Arthritis & Rheumatology
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