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Arthritis & Rheumatology

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https://www.readbyqxmd.com/read/28182854/anti-citrullinated-protein-antibodies-are-associated-with-neutrophil-extracellular-traps-in-the-sputum-in-relatives-of-rheumatoid-arthritis-patients
#1
M Kristen Demoruelle, Kylie K Harrall, Linh Ho, Monica M Purmalek, Nickie L Seto, Heather M Rothfuss, Michael H Weisman, Joshua J Solomon, Aryeh Fischer, Yuko Okamoto, Lindsay B Kelmenson, Mark C Parish, Marie Feser, Chelsie Fleischer, Courtney Anderson, Michael Mahler, Jill M Norris, Mariana J Kaplan, Brian D Cherrington, V Michael Holers, Kevin D Deane
OBJECTIVES: Studies suggest that rheumatoid arthritis (RA)-related autoimmunity is initiated at a mucosal site. However, the factors associated with the mucosal generation of this autoimmunity are unknown, especially in individuals who are at-risk for future RA. Therefore, we tested anti-cyclic citrullinated peptide (anti-CCP) antibodies in the sputum of RA-free first-degree relatives (FDRs) of RA patients and patients with classifiable RA. METHODS: We evaluated induced sputum and serum from 67 FDRs and 20 RA subjects for anti-CCP-IgA and anti-CCP-IgG, with cut-off levels for positivity determined in a control population...
February 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28141919/effect-of-corticosteroids-and-cyclophosphamide-on-sex-hormone-profiles-in-male-patients-with-systemic-lupus-erythematosus-and-systemic-sclerosis
#2
Laurent Arnaud, Annica Nordin, Hannes Lundholm, Elisabet Svenungsson, Erik Hellbacher, Johan Wikner, Agneta Zickert, Iva Gunnarsson
OBJECTIVE: Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc) are predominantly female autoimmune diseases, therefore men are less well investigated. We analysed sex hormone levels in male patients with SLE and SSc comparatively to controls, in relation with use of corticosteroids and cyclophosphamide. METHODS: Sex hormone levels were measured from fasting blood samples in male patients with SLE (n=71), SSc (n=29) and compared to population-based age-matched male controls...
January 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28141918/pro-fibrotic-infrapatellar-fat-pad-remodeling-without-m1-macrophage-polarization-precedes-knee-osteoarthritis-in-diet-induced-obese-mice
#3
Erika Barboza, Joanna Hudson, Wan-Pin Chang, Susan Kovats, Rheal A Towner, Robert Silasi-Mansat, Florea Lupu, Collin Kent, Timothy M Griffin
OBJECTIVE: To test the hypothesis that high-fat (HF) diet-induced obesity increases pro-inflammatory cytokine expression, macrophage infiltration and M1 polarization in the infrapatellar fat pad (IFP) prior to knee cartilage degeneration. METHODS: We characterized the effect of HF feeding on knee OA pathology, body adiposity, and glucose intolerance in male C57BL/6J mice and identified a diet duration that induces metabolic dysfunction prior to cartilage degeneration...
January 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28141917/enhanced-bruton-s-tyrosine-kinase-activity-in-peripheral-blood-b-lymphocytes-of-autoimmune-disease-patients
#4
Odilia B J Corneth, Gwenny M P Verstappen, Sandra M J Paulissen, Marjolein J W de Bruijn, Jasper Rip, Melanie Lukkes, Jan Piet van Hamburg, Erik Lubberts, Hendrika Bootsma, Frans G M Kroese, And Rudi W Hendriks
OBJECTIVE: Bruton's tyrosine kinase (BTK) transmits crucial survival signals from the B cell receptor (BCR) in B cells. Pharmacological BTK inhibition effectively diminishes disease symptoms in mouse models of autoimmunity and, conversely, transgenic BTK overexpression induces systemic autoimmunity in mice. We investigated BTK expression and activity in human B cells in the context of autoimmune disease. METHODS: Using intracellular flow cytometry, we quantified BTK expression and phosphorylation in peripheral blood B cell subsets in patients with rheumatoid arthritis (RA; n=30) and primary Sjogren's Syndrome (pSS; n=26) and matched healthy controls...
January 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28141915/analysis-of-atp8b4-f436l-missense-variant-in-a-large-systemic-sclerosis-cohort
#5
Elena López-Isac, Lara Bossini-Castillo, Ana B Palma, Shervin Assassi, Carmen P Simeón, Norberto Ortego-Centeno, Esther Vicente, Carlos Tolosa, Manel Rubio-Rivas, José A Román-Ivorra, Lorenzo Beretta, Gianluca Moroncini, Nicolas Hunzelmann, Jörg H W Distler, Gabriella Riemekasten, Jeska de Vries-Bouwstra, Alexandre E Voskuyl, Timothy R D J Radstake, Ariane Herrick, Christopher P Denton, Carmen Fonseca, Maureen D Mayes, Javier Martín
No abstract text is available yet for this article.
January 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28133931/a-randomized-double-blind-trial-of-abatacept-ctla4-ig-for-the-treatment-of-takayasu-s-arteritis
#6
Carol A Langford, David Cuthbertson, Steven R Ytterberg, Nader Khalidi, Paul A Monach, Simon Carette, Philip Seo, Larry W Moreland, Michael Weisman, Curry L Koening, Antoine G Sreih, Robert Spiera, Carol A McAlear, Kenneth J Warrington, Christian Pagnoux, Kathleen McKinnon, Lindsy J Forbess, Gary S Hoffman, Renée Borchin, Jeffrey P Krischer, Peter A Merkel
OBJECTIVE: To compare the efficacy of abatacept to placebo for the treatment of Takayasu's arteritis (TAK). METHODS: In this multicenter trial, patients with newly-diagnosed or relapsing TAK were treated with abatacept 10 mg/kg IV on days 1, 15, 29, week 8, together with prednisone. At week 12, patients in remission underwent a double-blinded randomization to continue monthly abatacept or switch to placebo. Patients in both study arms received a standardized prednisone taper, reaching 20 mg daily at week 12 with discontinuation of prednisone at week 28 and remained on their randomized assignment until meeting criteria for early termination or until 12 months after enrollment of the last patient...
January 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28133925/a-randomized-double-blind-trial-of-abatacept-ctla4-ig-for-the-treatment-of-giant-cell-arteritis
#7
Carol A Langford, David Cuthbertson, Steven R Ytterberg, Nader Khalidi, Paul A Monach, Simon Carette, Philip Seo, Larry W Moreland, Michael Weisman, Curry L Koening, Antoine Sreih, Robert Spiera, Carol A McAlear, Kenneth J Warrington, Christian Pagnoux, Kathleen McKinnon, Lindsy J Forbess, Gary S Hoffman, Renée Borchin, Jeffrey P Krischer, Peter A Merkel
OBJECTIVE: To compare the efficacy of abatacept to placebo for giant cell arteritis (GCA). METHODS: In this multicenter trial, patients with newly-diagnosed or relapsing GCA were treated with abatacept 10 mg/kg IV on days 1, 15, 29, week 8, together with prednisone. At week 12, patients in remission underwent a double-blinded randomization to continue monthly abatacept or switch to placebo. Patients in both study arms received a standardized prednisone taper with discontinuation of prednisone at week 28...
January 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118538/peficitinib-a-jak-inhibitor-in-combination-with-limited-conventional-synthetic-dmards-in-the-treatment-of-moderate-to-severe-rheumatoid-arthritis
#8
Mark C Genovese, Maria Greenwald, Christine Codding, Anna Zubrzycka-Sienkiewicz, Alan J Kivitz, Annie Wang, Kathyjo Shay, Xuegong Wang, Jay P Garg, Mario H Cardiel
OBJECTIVE: To evaluate the efficacy and safety of orally administered once-daily peficitinib in patients with moderate-to-severe rheumatoid arthritis (RA) in combination with limited conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). METHODS: In this double-blind, randomized, phase IIb trial, patients with RA (N=289) were treated with peficitinib 25 mg, 50 mg, 100 mg, 150 mg, or matching placebo once daily for 12 weeks. Primary endpoint was the percentage of patients achieving an American College of Rheumatology (ACR) 20% response at Week 12...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118537/pharmacodynamics-safety-and-clinical-efficacy-of-amg-811-a-human-anti-interferon-%C3%AE-antibody-in-subjects-with-discoid-lupus-erythematosus
#9
Victoria P Werth, David Fiorentino, Barbara A Sullivan, Michael J Boedigheimer, Kit Chiu, Christine Wang, Gregory E Arnold, Michael A Damore, Jeannette Bigler, Andrew A Welcher, Chris B Russell, David A Martin, James B Chung
OBJECTIVE: Interferon (IFN)-γ is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study evaluated a single dose of AMG 811, an anti-IFN-γ antibody, in subjects with DLE. METHODS: This was a phase 1, randomized, double-blind, placebo-controlled, crossover study (sequence 1: AMG 811 followed by placebo; sequence 2: placebo followed by AMG 811). Subjects received a single subcutaneous dose of AMG 811 (180 mg) or placebo. Pharmacodynamic endpoints included global transcriptional analyses of lesional and nonlesional skin, IFN-γ Blockade Signature (IGBS) transcriptional score in skin and blood, keratinocyte IFN-γ RNA score, and serum CXCL-10 protein...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118536/csf-cytokines-correlate-with-aseptic-meningitis-and-blood-brain-barrier-function-in-neonatal-onset-multisystem-inflammatory-disease-nomid
#10
Jackeline Rodriguez-Smith, Yen-Chih Lin, Wanxia Li Tsai, Hanna Kim, Gina Montealegre-Sanchez, Dawn Chapelle, Yan Huang, Cailin H Sibley, Massimo Gadina, Robert Wesley, Bibiana Bielekova, Raphaela Goldbach-Mansky
OBJECTIVE: To evaluate proinflammatory cytokines and leukocyte subpopulations in cerebrospinal spinal fluid (CSF) and blood of NOMID patients post-treatment; and to compare inflammatory cytokines in CSF and blood in 6 patients treated with two IL-1 blockers, anakinra and canakinumab. METHODS: We immunophenotyped CSF on 17 anakinra-treated pediatric NOMID patients during routine follow-up visits between December 2011 and October 2013 and analyzed CSF cytokine levels in baseline and 3-5 years follow-up samples compared to healthy controls...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118535/speculating-about-human-entheseal-%C3%AE-%C3%AE-t-cells
#11
LETTER
Annika Reinhardt, Immo Prinz
No abstract text is available yet for this article.
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118534/disease-associated-anti-citrullinated-protein-memory-b-cells-in-rheumatoid-arthritis-persist-in-clinical-remission
#12
Adam J Pelzek, Caroline Grönwall, Pamela Rosenthal, Jeffrey D Greenberg, Mandy McGeachy, Larry Moreland, William F C Rigby, Gregg J Silverman
OBJECTIVE: In RA, autoreactive B cells are pathogenic drivers and sources of anti-citrullinated protein antibodies (ACPA) that serve as a diagnostic biomarker and predictor of worse long-term prognosis. Yet the immunobiologic significance of persistent ACPA production at a cellular level is poorly understood. METHODS: In a cross-sectional study of RA patients, we investigated for the presence of continued defects in immune homeostasis as a function of disease activity...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118533/efficacy-and-safety-of-subcutaneous-belimumab-in-systemic-lupus-erythematosus-a-randomized-double-blind-placebo-controlled-52-week-study
#13
William Stohl, Andreas Schwarting, Masato Okada, Morton Scheinberg, Andrea Doria, Anne E Hammer, Christi Kleoudis, James Groark, Damon Bass, Norma Lynn Fox, David Roth, David Gordon
Objective To assess the efficacy and safety of subcutaneous (SC) belimumab in patients with systemic lupus erythematosus (SLE). Methods Patients with moderate-to-severe SLE (SELENA-SLEDAI ≥8) were randomized (2:1) to weekly belimumab 200 mg SC or placebo by prefilled syringe, plus standard SLE therapy (SoC), for 52 weeks. Primary endpoint was SLE Responder Index (SRI4) at Week 52. Secondary endpoints were time to severe flare and reduction in corticosteroid dose. Safety was assessed by adverse event (AE) reporting and laboratory testing...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118524/a-multi-national-arab-genome-wide-association-study-identifies-new-genetic-associations-for-rheumatoid-arthritis
#14
Richa Saxena, Robert M Plenge, Andrew C Bjonnes, Hassan S Dashti, Yukinori Okada, Wessam Gad El Haq, Mohammed Hammoudeh, Samar Al Emadi, Basel K Masri, Hussein Halabi, Humeira Badsha, Imad W Uthman, Lauren Margolin, Namrata Gupta, Ziyad R Mahfoud, Marianthi Kapiri, Soha R Dargham, Grace Aranki, Layla A Kazkaz, Thurayya Arayssi
OBJECTIVE: Genetic factors underlying susceptibility to Rheumatoid Arthritis (RA) in Arab populations are largely unknown. We undertook a genome-wide association study (GWAS) of RA to explore generalizability of previously reported RA loci to Arabs and to discover new Arab-specific genetic loci. METHODS: The Genetics of Rheumatoid Arthritis in some Arab States Study is designed to examine the genetics and clinical features of RA patients from Jordan, Kingdom of Saudi Arabia, Lebanon, Qatar and the United Arab Emirates...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118521/treatment-of-tnf-tg-mice-with-anti-tnf-restores-lymphatic-contraction-repairs-lymphatic-vessels-and-may-increase-monocyte-macrophage-egress
#15
Echoe M Bouta, Igor Kuzin, Karen de Mesy Bentley, Ronald W Wood, Homaira Rahimi, Rui-Cheng Ji, Christopher T Ritchlin, Andrea Bottaro, Lianping Xing Bm, And Edward M Schwarz
BACKGROUND: Recent studies have demonstrated that there is an inverse relationship between lymphatic egress and inflammatory arthritis in affected joints. As a model, TNF-transgenic (TNF-Tg) mice develop advanced arthritis following draining lymph node collapse, and loss of lymphatic contractions downstream of inflamed joints. As it is unknown if these lymphatic deficits are reversible, we tested the hypothesis that anti-TNF therapy reduces advanced inflammatory-erosive arthritis, associated with restoration of lymphatic contractions, repair of damaged lymphatic vessels, and evidence of increased monocyte egress...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28118520/could-%C3%AE-%C3%AE-t-cells-explain-zoledronic-acid-adverse-events
#16
LETTER
Cristian Caimmi, Maurizio Rossini, Ombretta Viapiana, Luca Idolazzi, Giovanni Adami, Davide Gatti
No abstract text is available yet for this article.
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28086002/immune-array-analysis-in-sporadic-inclusion-body-myositis-reveals-hla-drb1-amino-acid-heterogeneity-across-the-myositis-spectrum
#17
Simon Rothwell, Robert G Cooper, Ingrid E Lundberg, Peter K Gregersen, Michael G Hanna, Pedro M Machado, Megan K Herbert, Ger J M Pruijn, James B Lilleker, Mark Roberts, John Bowes, Michael F Seldin, Jiri Vencovsky, Katalin Danko, Vidya Limaye, Albert Selva-O'Callaghan, Hazel Platt, Øyvind Molberg, Olivier Benveniste, Timothy R D J Radstake, Andrea Doria, Jan De Bleecker, Boel De Paepe, Christian Gieger, Thomas Meitinger, Juliane Winkelmann, Christopher I Amos, William E Ollier, Leonid Padyukov, Annette T Lee, Janine A Lamb, Hector Chinoy
OBJECTIVE: Inclusion body myositis (IBM) is characterised by a combination of inflammatory and degenerative changes affecting muscle. While the primary cause of IBM is unknown, genetic factors may influence disease susceptibility. We conducted the largest genetic association study to date in IBM, investigating immune-related genes using the Immunochip. METHODS: 252 Caucasian IBM cases were recruited from 11 countries through the Myositis Genetics Consortium (MYOGEN), and compared with 1,008 ethnically matched controls...
January 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28086001/a-reddish-finding-in-synovial-fluid-hematoidin
#18
Mariano Andrés, Eliseo Pascual
No abstract text is available yet for this article.
January 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28086000/a-dual-role-for-ucma-in-osteoarthritis-inhibition-of-aggrecanases-and-promotion-of-bone-turnover
#19
Michael Stock, Stefanie Menges, Nicole Eitzinger, Maria Geßlein, Renate Botschner, Laura Wormser, Alfiya Distler, Ursula Schlötzer-Schrehardt, Katharina Dietel, Jörg Distler, Christian Beyer, Kolja Gelse, Klaus Engelke, Marije I Koenders, Wim van den Berg, Klaus von der Mark, Georg Schett
OBJECTIVE: Cartilage damage and subchondral bone changes are closely connected in osteoarthritis. How these processes are interlinked is however incompletely understood to date. Here, we investigate the mechanistic role of the cartilage-derived protein UCMA in osteoarthritis-related cartilage and bone changes. METHODS: UCMA expression was assessed in healthy and osteoarthritic human and mouse cartilage. DMM-induced osteoarthritis was performed in WT and Ucma-deficient mice analysing cartilage and bone changes...
January 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28085999/immune-related-adverse-events-with-the-use-of-checkpoint-inhibitors-for-immunotherapy-of-cancer
#20
REVIEW
Maria E Suarez-Almazor, Sang T Kim, Noha Abdel-Wahab, Adi Diab
No abstract text is available yet for this article.
January 13, 2017: Arthritis & Rheumatology
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