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Arthritis & Rheumatology

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https://www.readbyqxmd.com/read/28512998/implementation-of-treat-to-target-in-rheumatoid-arthritis-through-a-learning-collaborative-results-of-the-traction-randomized-controlled-trial
#1
Daniel H Solomon, Elena Losina, Bing Lu, Agnes Zak, Cassandra Corrigan, Sara B Lee, Jenifer Agosti, Asaf Bitton, Leslie R Harrold, Ted Pincus, Helga Radner, Zhi Yu, Josef S Smolen, Liana Fraenkel, Jeffrey N Katz
BACKGROUND: Treat to target (TTT) is an accepted paradigm for management of rheumatoid arthritis (RA), but some evidence suggests poor adherence. We tested the effects of a group-based multi-site improvement Learning Collaborative (LC) on adherence to TTT. METHODS: We conducted a cluster-randomized quality improvement trial with wait-list control across 11 rheumatology sites in the US. The intervention entailed a 9-month group-based LC that incorporated rapid-cycle improvement methods...
May 17, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28511292/gut-inflammation-in-hla-b27-transgenic-rats-alters-the-monocyte-compartment-and-its-osteoclastogenic-potential
#2
Cecilia Ansalone, Lotta Utriainen, Simon Milling, Carl S Goodyear
Objective To investigate the relationship between intestinal inflammation and the central and peripheral innate immune system, in the pathogenesis of HLA-B27 associated spondyloarthritis. Methods The myeloid compartment of the bone marrow and blood of HLA-B27 transgenic (B27), control HLA-B7 transgenic (B7), and non-transgenic rats were evaluated by flow cytometry. Plasma from rats were assessed by ELISA for CCL2 and IL-1α levels. Rats were treated for 4 weeks with antibiotics and the blood and bone marrow myeloid compartments were evaluated by flow cytometry...
May 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28511289/human-enthesis-group-3-innate-lymphoid-cells
#3
Richard J Cuthbert, Evangelos M Fragkakis, Robert Dunsmuir, Zhi Li, Mark Coles, Helena Marzo-Ortega, Peter Giannoudis, Elena Jones, Yasser M El-Sherbiny, Dennis McGonagle
Objective Group 3 innate lymphoid cells (ILC3s) play a pivotal role in barrier tissues such as the gut and the skin, two important sites of disease in spondyloarthropathy (SpA). It was investigated whether normal and injured human enthesis, the key target tissue in early SpA, harboured ILC3s in entheseal soft tissue (EST) and adjacent peri-entheseal bone (PEB). Methods Interspinous ligament and spinous process bone was collected from donors with no systemic inflammatory disease, enzymatically digested and immunophenotyped...
May 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28511285/increased-f4-80-hi-macrophages-is-associated-with-suppression-of-serum-transfer-induced-arthritis-in-mice-with-flip-reduced-in-myeloid-cells
#4
Qi-Quan Huang, Robert Birket, Renee E Doyle, G Kenneth Haines, Harris Perlman, Bo Shi, Philip Homan, Lianping Xing, Richard M Pope
OBJECTIVE: Macrophages are critical in the pathogenesis of rheumatoid arthritis (RA). We recently demonstrated that FLIP (FLICE-like inhibitory protein) is necessary for the differentiation and/or survival of macrophages. We also identified that FLIP is highly expressed in RA synovial macrophages. This study was performed to determine if the reduction of Flip in macrophages would reduce synovial tissue macrophages and ameliorate serum transfer induced arthritis (STIA). METHODS: Mice with Flip deleted in myeloid cells (Flip(f/f) LysM(c/+) mice) and littermate controls were employed...
May 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28511282/livedoid-vasculopathy
#5
Evangelia Zampeli, Haralampos M Moutsopoulos
No abstract text is available yet for this article.
May 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28493328/screening-of-181-patients-with-antibody-deficiency-for-deficiency-of-adenosine-deaminase-2-sheds-new-light-on-the-disease-in-adulthood
#6
Johanna Schepp, Michele Proietti, Natalie Frede, Mary Buchta, Katrin Hübscher, Jessica Rojas Restrepo, Sigune Goldacker, Klaus Warnatz, Jana Pachlopnik Schmid, Andrea Duppenthaler, Vassilios Lougaris, Ignacio Uriarte, Susan Kelly, Michael Hershfield, Bodo Grimbacher
OBJECTIVE: We aimed to test the relevance of Deficiency of Adenosine Deaminase 2 in patients with antibody deficiency and describe the clinical picture of the disease in adulthood. METHODS: We screened for DADA2 in a cohort of 181 patients with antibody deficiency with and without vascular lesions by the means of Next-Generation-Sequencing and targeted Sanger Sequencing. All mutations were confirmed by determining the ADA2 enzymatic activity levels in dried plasma spots...
May 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28493323/rheumatoid-arthritis-is-characterized-by-early-changes-of-the-cortical-micro-channel-comic-system-in-the-bare-area-of-the-joints
#7
David Werner, David Simon, Matthias Englbrecht, Fabian Stemmler, Christoph Simon, Andreas Berlin, Judith Haschka, Nina Renner, Thomas Buder, Klaus Engelke, Axel J Hueber, Jürgen Rech, Georg Schett, Arnd Kleyer
OBJECTIVE: To characterize the specific structural properties of the erosion-prone bare area of the human joint and to search for early microstructural changes in this region during rheumatoid arthritis Methods: An initial cadaveric study was used for exact localization of the bare area of the metacarpal heads, detection of cortical micro-channels (CoMiCs) in this region by high-resolution peripheral computed tomography (HR-pQCT) and, after anatomical dissection, their validation by micro-computed tomography (μCT)...
May 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28482144/open-label-phase-ii-study-to-assess-efficacy-and-safety-of-canakinumab-treatment-in-active-hyperimmunoglobulinemia-d-with-periodic-fever-syndrome
#8
Juan I Arostegui, Jordi Anton, Inmaculada Calvo, Angel Robles, Estibaliz Iglesias, Berta López-Montesinos, Romain Banchereau, Seunghee Hong, Yolandi Joubert, Guido Junge, Virginia Pascual, Jordi Yagüe
OBJECTIVE: To evaluate the efficacy and safety of canakinumab treatment in active hyperimmunoglobulinemia D with periodic fever syndrome (HIDS). METHODS: This was a 3-part, open-label study with a 6-month treatment period (P1; 300 mg or 4 mg/kg q6w), a 6-month withdrawal period (P2), and a 24-month treatment period (P3). The primary endpoint was reduction in frequency of attacks during treatment period compared with the historical period (HP; period in which patients did not receive drugs other than NSAIDs and/or steroids)...
May 8, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28482140/reply-to-what-is-the-true-prevalence-of-arthritis-in-the-u-s
#9
LETTER
Jennifer M Hootman, Charles G Helmick
No abstract text is available yet for this article.
May 8, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28482138/corrected-estimates-for-the-prevalence-of-self-reported-doctor-diagnosed-arthritis-among-us-adults
#10
LETTER
S Reza Jafarzadeh, David T Felson
No abstract text is available yet for this article.
May 8, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28480630/a-prospective-study-of-the-impact-of-current-poverty-history-of-poverty-and-exiting-poverty-on-accumulation-of-disease-damage-in-sle
#11
Edward Yelin, Laura Trupin, Jinoos Yazdany
OBJECTIVE: To estimate the effect of current poverty, number of years in poverty, and exiting poverty on disease damage accumulation in SLE. METHODS: 783 persons with SLE were followed from 2003-2015 through annual structured interviews. Respondents were categorized in each year by whether they were in households ≤125% of the Federal Poverty Level. Linear and logistic regression were used to assess the impact of poverty in 2009, number of years in poverty between 2003 and 2009, and permanent exits from poverty as of 2009 on extent of disease damage or accumulation of a clinically meaningful increase in disease damage by 2015...
May 8, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28471497/haploinsufficiency-of-nadph-oxidase-subunit-ncf2-is-sufficient-to-accelerate-full-blown-lupus-in-nzm-2328-mice
#12
Chaim O Jacob, Ning Yu, Dae-Goon Yoo, Lizet J Perez-Zapata, Emilia Alina Barbu, Mariana J Kaplan, Monica Purmalek, Jeanette T Pingel, Rachel A Idol, Mary C Dinauer
OBJECTIVE: We have previously established that NCF2 (Neutrophil cytosolic factor 2) is a lupus predisposing gene and identified lupus patients with point mutations that are predicted to cause reduced NADPH oxidase activity. This study was undertaken to investigate the relationship between reduced leukocyte NADPH oxidase activity and immune dysregulation associated with SLE. METHODS: We generated NCF2-null mice, in which NADPH oxidase activity is absent, on the non-autoimmune C57BL/6 background and on the NZM...
May 4, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28471483/human-sle-bone-marrow-mesenchymal-stem-cells-bmscs-have-a-senescence-associated-secretory-phenotype-sasp-mediated-by-a-mavs-ifn%C3%AE-feedback-loop
#13
Lin Gao, Anna K Bird, Nida Meednu, Kristin Dauenhauer, Jane Liesveld, Jennifer Anolik, R John Looney
Objective - BMSCs create a special microenvironment for hematopoiesis and immunity and also display robust immunomodulatory properties which are impaired in SLE. This study was undertaken to define the mechanisms of defects in human SLE BMSCs. Methods - Patients fulfilling SLE classification criteria and healthy controls were recruited under an Institutional Review Board approved protocol (n=6 each). BMSCs were isolated with low density Ficoll/Hypaque. BMSCs were verified by flow cytometry and studied using immunocytochemistry, real-time PCR, western blotting, comet assay, beta-galactosidase assay, and RNA interference...
May 4, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28470947/lifetime-risk-of-symptomatic-hand-osteoarthritis-the-johnston-county-osteoarthritis-project
#14
Jin Qin, Kamil E Barbour, Louise B Murphy, Amanda E Nelson, Todd A Schwartz, Charles G Helmick, Kelli D Allen, Jordan B Renner, Nancy A Baker, Joanne M Jordan
OBJECTIVE: Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present study was to estimate the overall lifetime risk of symptomatic hand OA, and the stratified lifetime risk according to potential risk factors. METHODS: Data were obtained from 2,218 adult subjects (ages ≥45 years) in the Johnston County Osteoarthritis Project, a population-based prospective cohort study among residents of Johnston County, North Carolina...
May 4, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28470662/arteriovenous-fistula-steal-syndrome-causes-severe-tophaceous-gout
#15
Jan Neumann, Susanne Kisban, Stephan Kemmner, Uwe Heemann, Philipp Moog, Christoph Schmaderer
No abstract text is available yet for this article.
May 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28464560/matriptase-induces-metalloproteinase-dependent-aggrecanolysis-in-vitro-and-in-vivo-multiple-mechanisms-promote-cartilage-damage-in-osteoarthritis
#16
David J Wilkinson, Angela Habgood, Heather K Lamb, Paul Thompson, Alastair R Hawkins, Antoine Désilets, Richard Leduc, Torsten Steinmetzer, Maya Hammami, Melody S Lee, Charles S Craik, Sharon Watson, Hua Lin, Jennifer M Milner, Andrew D Rowan
Objectives To assess the ability of the type II transmembrane serine proteinase matriptase to promote aggrecan loss from cartilage of osteoarthritis (OA) patients, and whether matriptase inhibition could prevent aggrecan loss and cartilage damage in experimental OA. Methods Aggrecan release was assessed from human OA cartilage explants and human stem cell-derived cartilage discs, whilst cartilage conditioned media were used for western blotting. Gene expression was analysed by real-time PCR. Murine OA was induced by surgical destabilisation of the medial meniscus, and matriptase inhibitors delivered via osmotic mini-pump or intra-articular injection...
May 2, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28464528/induction-of-scleroderma-fibrosis-in-skin-humanized-mice-by-administration-of-anti-platelet-derived-growth-factor-receptor-agonistic-autoantibodies
#17
LETTER
Michele M Luchetti, Fernado Larcher, Gianluca Moroncini, Silvia Svegliati, Enrico V Avvedimento, Armando Gabrielli
No abstract text is available yet for this article.
May 2, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28464512/commentary-on-the-article-skin-humanized-mice-for-scleroderma-fibrosis-induction-of-scleroderma-fibrosis-in-skin-humanized-mice-by-anti-platelet-derived-growth-factor-receptor-agonistic-autoantibodies-by-luchetti-et-al
#18
LETTER
https://www.readbyqxmd.com/read/28464470/sarcoid-myofasciitis
#19
Ryo Rokutanda, Yutaka Tomishima, Masato Okada
No abstract text is available yet for this article.
May 2, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28454209/reply-to-understanding-the-role-of-antibodies-as-markers-of-cancer-coexistence-in-systemic-sclerosis-by-bernal-bello-et-al
#20
LETTER
Ami A Shah, George Xu, Antony Rosen, Laura K Hummers, Fredrick M Wigley, Stephen J Elledge, Livia Casciola-Rosen
No abstract text is available yet for this article.
April 28, 2017: Arthritis & Rheumatology
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