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Canadian Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28913325/bone-loss-prevention-of-bisphosphonates-in-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#1
REVIEW
Yan Hu, Xiaoting Chen, Xiaojing Chen, Shuang Zhang, Tianyan Jiang, Jing Chang, Yanhong Gao
OBJECTIVE: The purpose of this study was to evaluate the effect of bisphosphonates in improving bone mineral density (BMD) and decreasing the occurrence rate of fractures and adverse events in patients with inflammatory bowel disease (IBD). METHODS: Randomized controlled trials (RCTs) which use bisphosphonates in IBD patients were identified in PubMed, MEDLINE database, EMBASE database, Web of Knowledge, and the Cochrane Databases between 1990 and June 2016. People received bisphosphonate or placebos with a follow-up of at least one year were also considered...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28815170/the-geography-of-primary-hepatic-neoplasms-treatments-in-canada-changes-in-latitudes-and-changes-in-attitudes
#2
Matthew Cwinn, Gordon Walsh, Sheikh Hasibur Rahman, Michele Molinari
BACKGROUND: Studies on treatment modalities for primary hepatic neoplasms (PHN) in Canada are lacking. Our primary aim was to analyze the age-standardized incidence of hepatic resection, ablation, transplantation, and embolization for PHN between 2002 and 2013. Secondary aim was to evaluate temporal trends for these treatment modalities. STUDY DESIGN: National Canadian Cancer Registries were accessed for relevant epidemiological data. Age-standardized incidence of treatment ratios (SIRs) was calculated and comparisons were performed for Atlantic Canada, Ontario, the Prairies, and British Columbia...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28812008/evaluation-of-adrenal-function-in-nonhospitalized-patients-with-cirrhosis
#3
Maryam Moini, Mitra Yazdani Sarvestani, Mesbah Shams, Masood Nomovi
BACKGROUND: Patients with cirrhosis and advancing hepatic insufficiency may show various degrees of other organ malfunction, including brain, kidney, and lung. Several studies have also shown a high prevalence of adrenal insufficiency in cirrhotic patients that may cause hemodynamic instability. MATERIALS AND METHODS: In this study we prospectively evaluated adrenal function in a population of nonhospitalized cirrhotic patients. Categorization of liver disease severity was done according to model for end-stage liver disease (MELD) score...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28808653/acyl-coa-synthetase-5-promotes-the-growth-and-invasion-of-colorectal-cancer-cells
#4
Shihua Ding, Shaohui Tang, Min Wang, Donghai Wu, Haijian Guo
BACKGROUND AND AIMS: Acyl-CoA synthetase 5 (ACS5) has been reported to be associated with the development of various cancers, but the role of it in colorectal cancer (CRC) is not well understood. The present study aimed to explore the potential role of ACS5 in the development and progression of CRC. METHODS: ACS5 expression in CRC tissues and CRC cell lines was examined, and its clinical significance was analyzed. The role of ACS5 in cell proliferation, apoptosis, and invasion was examined in vitro...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28804705/possible-involvement-of-liver-resident-macrophages-kupffer-cells-in-the-pathogenesis-of-both-intrahepatic-and-extrahepatic-inflammation
#5
Yuki Kakinuma, Takuya Kimura, Yoshifumi Watanabe
Liver resident macrophages designated Kupffer cells (KCs) form the largest subpopulation of tissue macrophages. KCs are involved in the pathogenesis of liver inflammation. However, the role of KCs in the systemic inflammation is still elusive. In this study, we examined whether KCs are involved in not only intrahepatic inflammation but also extrahepatic systemic inflammation. Administration of clodronate liposomes resulted in the KC deletion and in the suppression of liver injury in T cell-mediated hepatitis by ConA as a local acute inflammation model, while the treatment did not influence dextran sulfate sodium- (DSS-) induced colitis featured by weight loss, intestinal shrink, and pathological observation as an ectopic local acute inflammation model...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28785552/corrigendum-to-assessment-of-school-readiness-in-chronic-cholestatic-liver-disease-a-pilot-study-examining-children-with-and-without-liver-transplantation
#6
Anna Gold, Alaine Rogers, Elizabeth Cruchley, Stephanie Rankin, Arpita Parmar, Binita M Kamath, Yaron Avitzur, Vicky Lee Ng
[This corrects the article DOI: 10.1155/2017/9873945.].
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28785551/the-prevalence-of-hjortsjo-crook-sign-of-right-posterior-sectional-bile-duct-and-bile-duct-anatomy-in-ercp
#7
Hanan M Alghamdi, Afnan F Almuhanna, Bander F Aldhafery, Raed M AlSulaiman, Ahmed Almarhabi, Abdulaziz AlQurain
AIM: The frequency of the Right Posterior Sectional Bile Duct (RPSBD) hump sign in cholangiogram when it crosses over the right portal vein known as Hjortsjo Crook Sign and the bile duct anatomy are studied. Knowledge of the implication of positive sign can facilitate safe resection for both bile duct and portal vein. METHODS: Prospectively, we included 237 patients with indicated ERCP during a period from March 2010 to January 2015. RESULTS: The mean age (±SD) and male to female ratio were 38...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28781966/obesity-increases-prevalence-of-colonic-adenomas-at-screening-colonoscopy-a-canadian-community-based-study
#8
Theodore F Shapero, Grant I Chen, Tim Devlin, Alison Gibbs, Iain C Murray, Stanley Tran, Corey Weigensberg
BACKGROUND AND AIMS: Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. METHODS: We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calculated at enrolment. Hyperlipidemia (HL), hypertension (HT), and diabetes mellitus (DM) were identified. Details of colonoscopy, polypectomy, and histology were recorded...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28770186/corrigendum-to-prebiotics-a-novel-approach-to-treat-hepatocellular-carcinoma
#9
Naz Fatima, Tasleem Akhtar, Nadeem Sheikh
[This corrects the article DOI: 10.1155/2017/6238106.].
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28752083/recognition-of-lynch-syndrome-amongst-newly-diagnosed-colorectal-cancers-at-st-paul-s-hospital
#10
Steven Pi, Estello Nap-Hill, Jennifer Telford, Robert Enns
BACKGROUND: Lynch Syndrome (LS) is the most common cause of inherited colorectal cancer (CRC). In British Columbia, most centres still use clinical criteria (Amsterdam II, Revised Bethesda, or the BC Cancer Agency's criteria) to determine who should undergo further first-line testing in the form of microsatellite instability or immunohistochemistry staining. Given the limitations with this strategy, LS is thought to be underrecognized. OBJECTIVE: To investigate whether LS is truly underrecognized when compared to the reported prevalence...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28752082/corrigendum-to-evaluation-and-management-of-skeletal-health-in-celiac-disease-position-statement
#11
Mona A Fouda, Aliya A Khan, Muhammad Sultan, Lorena P Rios, Karen McAssey, David Armstrong
[This corrects the article on p. 819 in vol. 26.].
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28740843/comparative-readability-analysis-of-online-patient-education-resources-on-inflammatory-bowel-diseases
#12
Rishabh Gulati, Mohammad Nawaz, Linh Lam, Nikolaos T Pyrsopoulos
BACKGROUND: The National Institutes of Health recommend a readability grade level of less than 7th grade for patient directed information. In this study, we use validated readability metrics to analyze patient information from prominent websites pertaining to ulcerative colitis and Crohn's disease. METHODS: The terms "Crohn's Disease," "Ulcerative Colitis," and "Inflammatory Bowel Disease" were queried on Google and Bing. Websites containing patient education material were saved as a text file and then modified through expungement of medical terminology that was described within the text...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28713797/health-related-quality-of-life-after-pediatric-liver-transplantation-a-qualitative-analysis-of-the-perspectives-of-health-care-providers
#13
Mar Miserachs, David B Nicholas, Anthony R Otley, Vicky Lee Ng
With improved survival outcomes after pediatric liver transplantation (LT), health-related quality of life (HRQoL) is an important outcome metric. Understanding the elements contributing to HRQoL after LT in children would enable more targeted strategies towards optimizing best outcomes. This qualitative study aimed to explore health care providers (HCP) perceptions about HRQoL after pediatric LT. Thirteen experienced HCP participated in two focus group discussions. Data analysis via a thematic analysis approach revealed 4 major themes: "LT as a facilitator of better HRQoL," "coping and adapting to LT," "living with a transplanted liver," and "the family context...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28685131/relationship-between-nonalcoholic-fatty-liver-disease-and-vitamin-d-nutritional-status-in-extreme-obesity
#14
Adryana Cordeiro, Silvia Pereira, Carlos José Saboya, Andrea Ramalho
AIM: To evaluate the relationship of nonalcoholic fatty liver disease (NAFLD) with nutritional status of vitamin D in extreme obesity. METHODS: Descriptive cross-sectional study in individuals with class III obesity (BMI ≥ 40 kg/m(2)), aged ≥ 20 years to < 60 years. Data were obtained for weight, height, waist circumference (WC), and serum 25-hydroxyvitamin D (25(OH)D) levels. Vitamin D analysis was performed by high performance liquid chromatography (HPLC) and the cutoff points used for its classification were < 20 ng/mL for deficiency and 20-29...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28656129/the-effects-of-synbiotic-bifidobacterium-lactis-b94-plus-inulin-addition-on-standard-triple-therapy-of-helicobacter-pylori-eradication-in-children
#15
Gonca Handan Ustundag, Halime Altuntas, Yasemin Dilek Soysal, Furuzan Kokturk
AIM: The aim of this study is to evaluate the effects of the synbiotic Bifidobacterium lactis B94 plus inulin addition to the standard triple therapy on Helicobacter pylori (H. pylori) infection eradication rates. METHODS: Children aged 6-16 years who had biopsy proven H. pylori infection were randomly classified into two groups. The first group received the standard triple therapy consisting of amoxicillin + clarithromycin + omeprazole. The second group was treated with the standard triple therapy and Bifidobacterium lactis B94 (5 × 10(9) CFU/dose) plus inulin (900 mg) for 14 days, concurrently...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28634576/disability-in-patients-with-inflammatory-bowel-disease-correlations-with-quality-of-life-and-patient-s-characteristics
#16
Konstantinos Argyriou, Andreas Kapsoritakis, Konstantinos Oikonomou, Anastassios Manolakis, Eirini Tsakiridou, Spyridon Potamianos
BACKGROUND: Inflammatory bowel diseases may cause significant disability. However, little is known regarding the life domains where patients encounter most limitations. OBJECTIVES: To assess patients' overall disability and determine the life domains where most restrictions were applied. Secondarily, we sought for possible relationships among disability, quality of life (HRQoL), and population characteristics. METHOD: The study lasted for two years (2013-2015) and included 200 patients [52%  ulcerative  colitis  (UC)] from a referral centre...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28634575/association-between-plasmatic-ceramides-profile-and-ast-alt-ratio-c14-0-ceramide-as-predictor-of-hepatic-steatosis-in-adolescents-independently-of-obesity
#17
Jorge Maldonado-Hernández, Gabriela E Saldaña-Dávila, Mónica I Piña-Aguero, Benjamín A Núñez-García, Mardia G López-Alarcón
OBJECTIVE: To assess the association between plasma ceramides and hepatic steatosis (HS) in adolescents, independently of obesity. MATERIALS AND METHODS: Ninety-four adolescents from two previous studies conducted and published by our crew were included. Study subjects were stratified in three groups: normal weight (n = 18), obesity (n = 34), and obesity + HS (n = 42). The presence of HS was defined when ALT/AST ratio was <1. Ceramides subspecies (C14:0, C16:0, C18:0, C24:0, and C24:1) were determined by LC/MS...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28593172/allied-health-professional-support-in-pediatric-inflammatory-bowel-disease-a-survey-from-the-canadian-children-inflammatory-bowel-disease-network-a-joint-partnership-of-cihr-and-the-ch-i-l-d-foundation
#18
Wael El-Matary, Eric I Benchimol, David Mack, Hien Q Huynh, Jeff Critch, Anthony Otley, Colette Deslandres, Kevan Jacobson, Jennifer deBruyn, Matthew W Carroll, Eytan Wine, Johan Van Limbergen, Mary Sherlock, Kevin Bax, Sally Lawrence, Ernest Seidman, Robert Issenman, Thomas D Walters, Peter Church, Anne M Griffiths
OBJECTIVES: The current number of healthcare providers (HCP) caring for children with inflammatory bowel disease (IBD) across Canadian tertiary-care centres is underinvestigated. The aim of this survey was to assess the number of healthcare providers (HCP) in ambulatory pediatric IBD care across Canadian tertiary-care centres. METHODS: Using a self-administered questionnaire, we examined available resources in academic pediatric centres within the Canadian Children IBD Network...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28573132/prebiotics-a-novel-approach-to-treat-hepatocellular-carcinoma
#19
REVIEW
Naz Fatima, Tasleem Akhtar, Nadeem Sheikh
Hepatocellular carcinoma is one of the fatal malignancies and is considered as the third leading cause of death. Mutations, genetic modifications, dietary aflatoxins, or impairments in the regulation of oncogenic pathways may bring about liver cancer. An effective barrier against hepatotoxins is offered by gut-liver axis as a change in gut permeability and expanded translocation of lipopolysaccharides triggers the activation of Toll-like receptors which stimulate the process of hepatocarcinogenesis. Prebiotics, nondigestible oligosaccharides, have a pivotal role to play when it comes to inducing an antitumor effect...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28567370/maintenance-of-remission-with-partial-enteral-nutrition-therapy-in-pediatric-crohn-s-disease-a-retrospective-study
#20
Jacqueline M Schulman, Liat Pritzker, Ron Shaoul
BACKGROUND: Partial enteral nutrition (PEN) may be helpful for the maintenance of remission in pediatric Crohn's disease patients. AIMS: To evaluate the efficacy of PEN treatment for preventing clinical relapse. METHODS: We retrospectively assessed 42 pediatric Crohn's disease patients who entered clinical remission on 4-12 weeks of exclusive enteral nutrition (EEN) and were maintained on PEN as a supplementary diet. We evaluated the efficacy of the treatment at different time points using the weighted Pediatric Crohn Disease Activity Index (wPCDAI), Physician Global Assessment, laboratory parameters, and growth of each patient...
2017: Canadian Journal of Gastroenterology & Hepatology
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