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Canadian Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28529936/living-with-hepatitis-c-virus-a-systematic-review-and-narrative-synthesis-of-qualitative-literature
#1
REVIEW
Laura E Dowsett, Stephanie Coward, Diane L Lorenzetti, Gail MacKean, Fiona Clement
Background and Aims. The lived experience of HCV has not been well documented in the literature. The aim of this systematic review was to understand the experiences of living with Hepatitis C Virus (HCV). Methods. Five databases were searched from inception until January 19, 2015. Studies were included if they focused on adults diagnosed with HCV; reported experience living with HCV; and described original research. Results. 46 studies were included. Studies found that participants had reduced quality of life due to physical symptoms...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28491862/comparison-of-fecal-calprotectin-methods-for-predicting-relapse-of-pediatric-inflammatory-bowel-disease
#2
Saranya Kittanakom, Md Sharif Shajib, Kristine Garvie, Joceline Turner, Dan Brooks, Sufian Odeh, Robert Issenman, V Tony Chetty, Joseph Macri, Waliul I Khan
Background. Pediatric inflammatory bowel disease (IBD) is on the rise worldwide. Endoscopies are necessary for IBD assessment but are invasive, expensive, and inconvenient. Recently, fecal calprotectin (FCal) was proposed as a noninvasive and specific marker of gut inflammation. We evaluated the analytical performance of three FCal assays and their clinical performance in predicting relapse in pediatric IBD. Methods. This study used 40 pediatric IBD and 40 random non-IBD patients' fecal samples. Two automated ELISAs (Bühlmann and PhiCal® Calprotectin-EIA) and an EliA (Phadia 250 EliA-Calprotectin) were used to evaluate the analytical performance...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28487848/blood-urea-nitrogen-as-a-predictor-of-severe-acute-pancreatitis-based-on-the-revised-atlanta-criteria-timing-of-measurement-and-cutoff-points
#3
Suhan Lin, Wandong Hong, Zarrin Basharat, Qipin Wang, Jingye Pan, Mengtao Zhou
Background and Aims. This study evaluated the prognostic accuracy of BUN for severe acute pancreatitis (SAP) and in-hospital mortality (IHM) in terms of the best timing for BUN measurement and the optimal BUN cutoff points. Methods. BUN determinants at the time of admission and 24 hrs after hospital admission were recorded and analyzed statistically. The ability of BUN in predicting the SAP and the occurrence of IHM were assessed using the area under the receiver-operating characteristic (ROC) curve. Results...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28484687/gastroenterology-curriculum-in-the-canadian-medical-school-system
#4
ThucNhi Tran Dang, Clarence Wong, Lana Bistritz
Background and Purpose. Gastroenterology is a diverse subspecialty that covers a wide array of topics. The preclinical gastroenterology curriculum is often the only formal training that medical students receive prior to becoming residents. There is no Canadian consensus on learning objectives or instructional methods and a general lack of awareness of curriculum at other institutions. This results in variable background knowledge for residents and lack of guidance for course development. Objectives. (1) Elucidate gastroenterology topics being taught at the preclinical level...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28466002/efficacy-of-magnetic-sphincter-augmentation-versus-nissen-fundoplication-for-gastroesophageal-reflux-disease-in-short-term-a-meta-analysis
#5
REVIEW
Ming-Yu Chen, Di-Yu Huang, Angela Wu, Yi-Bin Zhu, He-Pan Zhu, Liu-Mei Lin, Xiu-Jun Cai
Background. The efficacy of Magnetic Sphincter Augmentation (MSA) and its outcomes for Gastroesophageal Reflux Disease (GERD) are uncertain. Therefore, we aimed to summarize and analyze the efficacy of two treatments for GERD. Methods. The meta-analysis search was performed, using four databases. All studies from 2005 to 2016 were included. Pooled effect was calculated using either the fixed or random effects model. Results. A total of 4 trials included 624 patients and aimed to evaluate the differences in proton-pump inhibitor use, complications, and adverse events...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28409147/incidence-and-predictors-of-advanced-liver-fibrosis-by-a-validated-serum-biomarker-in-liver-transplant-recipients
#6
Mamatha Bhat, Kathleen C Rollet-Kurhajec, Aparna Bhat, Amanda Farag, Marc Deschenes, Philip Wong, Peter Ghali, Giada Sebastiani
Background and Aims. Serum fibrosis biomarkers have shown good accuracy in the liver transplant (LT) population. We employed a simple serum biomarker to elucidate incidence and predictors of advanced fibrosis after LT over a long follow-up period. Methods. We included 440 consecutive patients who underwent LT between 1991 and 2013. Advanced liver fibrosis was defined as FIB-4 > 3.25 beyond 12 months after LT. Results. Over 2030.5 person-years (PY) of follow-up, 189 (43%) developed FIB-4 > 3.25, accounting for an incidence of 9...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28396854/a-hepatitis-c-educational-needs-assessment-of-canadian-healthcare-providers
#7
Reza Naghdi, Karen Seto, Carolyn Klassen, Didi Emokpare, Brian Conway, Melissa Kelley, Eric Yoshida, Hemant A Shah
Background and Aim. Despite advances in the treatment of chronic hepatitis C infection (CHC), it remains a major public health problem in Canada and globally. The knowledge of healthcare providers (HCPs) is critical to improve the care of CHC in Canada. To assess the current knowledge and educational needs of healthcare providers (HCPs) in the area of CHC management a national online survey was conducted. Method. An interprofessional steering committee designed a 29-question survey distributed through various direct and electronic routes...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28367429/the-efficacy-and-safety-of-12-weeks-of-sofosbuvir-and-ledipasvir-versus-sofosbuvir-ledipasvir-and-ribavirin-in-patients-with-chronic-hepatitis-c-genotype-1-who-have-cirrhosis-and-have-failed-prior-therapy-a-systematic-review-and-meta-analysis
#8
REVIEW
William Stokes, Carol Fenton, Fiona Clement, Matthew James, Paul Ronksley, Karen L Tang
Background. The recommended therapy for patients with chronic hepatitis C (CHC), genotype 1, who have cirrhosis and have failed prior therapy is 12 weeks of sofosbuvir (SOF), ledipasvir (LDV), and ribavirin (RBV). This recommendation is based on expert opinion, and the efficacy of 12 weeks of SOF/LDV compared to SOF/LDV/RBV in this patient population has not yet been established. Methods. We conducted a systematic review and meta-analysis. Two investigators independently searched electronic databases and relevant conference proceedings for randomized controlled trials comparing rates of sustained virologic response 12 weeks after therapy (SVR12) when using 12 weeks of SOF/LDV versus 12 weeks of SOF/LDV/RBV in patients with CHC, genotype 1, who have cirrhosis and failed previous therapy...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28349045/safety-profile-of-liver-fibroscan-in-patients-with-cardiac-pacemakers-or-implantable-cardioverter-defibrillators
#9
Yin Chan, Stephanie Pranke, Farid Rashidi, Shravan Nosib, Lawrence Worobetz
Background. Emerging evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery diseases and arrhythmias. The FibroScan (Echosens, France), a widely available, noninvasive device, is able to detect liver fibrosis and steatosis within this patient population. However, the FibroScan is currently contraindicated in patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD). Objective. To determine the safety profile of FibroScan testing in patients with PM or ICD...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28349044/vonoprazan-based-regimen-is-more-useful-than-ppi-based-one-as-a-first-line-helicobacter-pylori-eradication-a-randomized-controlled-trial
#10
Masafumi Maruyama, Naoki Tanaka, Daisuke Kubota, Masayuki Miyajima, Takefumi Kimura, Koujiro Tokutake, Ryujiro Imai, Toru Fujisawa, Hiromitsu Mori, Yoshiaki Matsuda, Shuichi Wada, Akira Horiuchi, Kendo Kiyosawa
Background. A new agent, potassium-competitive acid blocker vonoprazan (VPZ) has potent acid-inhibitory effects and may offer advantages over conventional H. pylori eradication therapies. We aimed to compare the eradication rate between VPZ-based treatment and PPI-based one. Methods. This randomized controlled trial was designed to assign 141 patients with H. pylori-positive gastritis to VPZ group (VPZ 20 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days) or PPI group (rabeprazole 20 mg or lansoprazole 30 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days)...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28321390/metabonomics-research-progress-on-liver-diseases
#11
REVIEW
Mengqian Yu, Ying Zhu, Qingwei Cong, Chunyan Wu
Metabolomics as the new omics technique develops after genomics, transcriptomics, and proteomics and has rapid development at present. Liver diseases are worldwide public health problems. In China, chronic hepatitis B and its secondary diseases are the common liver diseases. They can be diagnosed by the combination of history, virology, liver function, and medical imaging. However, some patients seldom have relevant physical examination, so the diagnosis may be delayed. Many other liver diseases, such as drug-induced liver injury (DILI), alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD), and autoimmune liver diseases, still do not have definite diagnostic markers; the diagnosis consists of history, medical imaging, and the relevant score...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28280718/response-to-comment-on-assessment-of-liver-stiffness-in-pediatric-fontan-patients-using-transient-elastography
#12
COMMENT
Becky Chen, Richard A Schreiber, Derek G Human, James E Potts, Orlee R Guttman
No abstract text is available yet for this article.
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28271055/treatment-algorithm-for-chronic-idiopathic-constipation-and-constipation-predominant-irritable-bowel-syndrome-derived-from-a-canadian-national-survey-and-needs-assessment-on-choices-of-therapeutic-agents
#13
Yvonne Tse, David Armstrong, Christopher N Andrews, Alain Bitton, Brian Bressler, John Marshall, Louis W C Liu
Background. Chronic idiopathic constipation (CIC) and constipation-predominant irritable bowel syndrome (IBS-C) are common functional lower gastrointestinal disorders that impair patients' quality of life. In a national survey, we aimed to evaluate (1) Canadian physician practice patterns in the utilization of therapeutic agents listed in the new ACG and AGA guidelines; (2) physicians satisfaction with these agents for their CIC and IBS-C patients; and (3) the usefulness of these new guidelines in their clinical practice...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28265555/aseptic-abscesses-and-inflammatory-bowel-disease-two-cases-and-review-of-literature
#14
REVIEW
Natasha Bollegala, Rishad Khan, Michael A Scaffidi, Ahmed Al-Mazroui, Jenna Tessolini, Adrienne Showler, Errol Colak, Samir C Grover
Background. Aseptic abscesses (AA) are sterile lesions that represent an extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Though Canada has the highest prevalence of IBD in the world, reports of IBD-associated AA are absent in Canada. This may represent a different IBD phenotype or underrecognition and underreporting. Purpose. To explore AA as a possible EIM of IBD and evaluate clinical and investigative findings among patients with IBD-associated AA. Methods. Retrospective chart and literature reviews were performed to find cases of IBD-associated AA at our institution and in the literature...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28239601/public-versus-private-drug-insurance-and-outcomes-of-patients-requiring-biologic-therapies-for-inflammatory-bowel-disease
#15
COMPARATIVE STUDY
Amir Rumman, Roberto Candia, Justina J Sam, Kenneth Croitoru, Mark S Silverberg, A Hillary Steinhart, Geoffrey C Nguyen
Background. Antitumor necrosis factor (anti-TNF) therapy is a highly effective but costly treatment for inflammatory bowel disease (IBD). Methods. We conducted a retrospective cohort study of IBD patients who were prescribed anti-TNF therapy (2007-2014) in Ontario. We assessed if the insurance type was a predictor of timely access to anti-TNF therapy and nonroutine health utilization (emergency department visits and hospitalizations). Results. There were 268 patients with IBD who were prescribed anti-TNF therapy...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28194394/assessment-of-school-readiness-in-chronic-cholestatic-liver-disease-a-pilot-study-examining-children-with-and-without-liver-transplantation
#16
Anna Gold, Alaine Rogers, Elizabeth Cruchley, Stephanie Rankin, Arpita Parmar, Binita M Kamath, Yaron Avitzur, Vicky Lee Ng
Background. Assessment of school readiness evaluates physical, social-emotional, and neuropsychological domains essential for educational success. Cognitive testing of preschool aged children with chronic liver disease may guide more timely interventions and focused efforts by health care providers. Patients and Methods. Children with chronic cholestatic liver disease diagnosed as an infant and still with their native liver (NL) and children who received a liver transplant (LT) before age of 2 years underwent testing with a battery of well-validated pediatric psychometric measures...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28191453/anti-tnf-mediated-modulation-of-prohepcidin-improves-iron-availability-in-inflammatory-bowel-disease-in-an-il-6-mediated-fashion
#17
Flaminia Cavallaro, Lorena Duca, Laura Francesca Pisani, Roberta Rigolini, Luisa Spina, Gian Eugenio Tontini, Nadia Munizio, Elena Costa, Maria Domenica Cappellini, Maurizio Vecchi, Luca Pastorelli
Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and of anaemia of chronic disease (ACD). ACD is characterized by macrophage iron retention induced by proinflammatory cytokines. Hepcidin is the master inducer of iron accumulation during ACD, and its production is mainly regulated by IL-6 and the novel erythroid hormone erythroferrone (ERFE). This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin production and the levels of its main regulators, leading to a restoration of iron homeostasis...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28182112/prevalence-and-anatomic-distribution-of-serrated-and-adenomatous-lesions-in-patients-with-inflammatory-bowel-disease
#18
Lik Hang Lee, Marietta Iacucci, Miriam Fort Gasia, Subrata Ghosh, Remo Panaccione, Stefan Urbanski
Background. Sessile serrated adenomas/polyps (SSA/Ps) and traditional serrated adenomas (TSAs) have not been well characterized in patients with inflammatory bowel disease (IBD). This study assesses the prevalence and anatomic distribution of SSA/Ps, TSAs, and conventional adenomas/dysplasia (Ad/Ds) in IBD patients. Methods. IBD patients with serrated, adenomatous, or hyperplastic lesions between 2005 and 2009 were identified in the regional tertiary-care hospital database. Clinicopathological information was reviewed and the histology of biopsies was reevaluated...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28164081/grazoprevir-and-elbasvir-in-patients-with-genotype-1-hepatitis-c-virus-infection-a-comprehensive-efficacy-and-safety-analysis
#19
Yinan Yao, Ming Yue, Jie Wang, Hongbo Chen, Mei Liu, Feng Zang, Jun Li, Yun Zhang, Peng Huang, Rongbin Yu
Background. It is urgent for patients with hepatitis C virus (HCV) infection to find a safe, effective, and interferon-free regimen to optimize therapy. A comprehensive analysis was performed to evaluate the efficacy and safety of the grazoprevir combined with elbasvir, with or without ribavirin (RBV), in 777 treatment-naive and treatment-experienced patients with HCV genotype 1 infection from 3 randomized controlled trials (RCTs). Method. We collected data from the following trials: C-WORTHY (NCT01717326), C-SALVAGE (NCT02105454), and C-EDGE (NCT02105467)...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28127545/advanced-hepatic-fibrosis-in-fatty-liver-disease-linked-to-hyperplastic-colonic-polyp
#20
Mahmud Mahamid, Omar Abu-Elhija, Tarik Yassin, William Nseir
Aim. Our study aims to determine possible association between biopsy-proven nonalcoholic steatohepatitis (NASH) and hyperplastic polyps (HP) of the colon. Methods. A retrospective cohort observational study. All subjects underwent screening colonoscopy within two years. Data were extracted from the patient charts including demographic, anthropometric measurement, vital signs, underlying diseases, medical therapy, laboratory data, results of the liver biopsy with degree of fibrosis and necroinflammatory activity, the colonoscopy report, and the pathological report of the extracted polyp...
2017: Canadian Journal of Gastroenterology & Hepatology
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