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Canadian Journal of Gastroenterology & Hepatology

Shilian Chen, Yaqin Zhang, Xuan Wu, Chaoyang Zhang, Guancheng Li
Some long noncoding RNAs (lncRNAs) display aberrantly high or low expression in hepatocellular carcinoma (HCC) and have the potential to serve as diagnostic biomarkers. Here, we accomplished a meta-analysis based on current studies to assess the diagnostic value of lncRNAs in HCC. Eligible literatures were systematically selected from PubMed, Web of Science, and Embase (up to January 20, 2018) according to defined inclusion and exclusion criteria. QUADAS scale was applied to the quality assessment of the included studies...
2018: Canadian Journal of Gastroenterology & Hepatology
Jersey Heitor da S Maués, Helem Ferreira Ribeiro, Giovanny R Pinto, Luana de Oliveira Lopes, Letícia M Lamarão, Carla Mariana F Pessoa, Caroline de Fátima Aquino Moreira-Nunes, Raimundo Miranda de Carvalho, Paulo P Assumpção, Juan A Rey, Rommel M Rodríguez Burbano
MYC is an oncogene responsible for excessive cell growth in cancer, enabling transcriptional activation of genes involved in cell cycle regulation, metabolism, and apoptosis, and is usually overexpressed in gastric cancer (GC). By using siRNA and Next-Generation Sequencing (NGS), we identified MYC -regulated differentially expressed Genes (DEGs) in three Brazilian gastric cancer cell lines representing the histological subtypes of GC (diffuse, intestinal, and metastasis). The DEGs were picked using Sailfish software, followed by Gene Set Enrichment Analysis (GSEA) and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis using KEGG...
2018: Canadian Journal of Gastroenterology & Hepatology
Sylvia Drazilova, Martin Janicko, Lubomir Skladany, Pavol Kristian, Marian Oltman, Maria Szantova, Dusan Krkoska, Eva Mazuchova, Lubica Piesecka, Veronika Vahalova, Marek Rac, Ivan Schreter, Ladislav Virag, Tomas Koller, Adriana Liptakova, Miriam Ondrasova, Peter Jarcuska
Background and Aims: Chronic hepatitis C is a systemic disease and type 2 diabetes mellitus (T2DM) belongs to more common extrahepatic. The aim of this study was to (i) explore the prevalence of impaired fasting glucose (IFG) and T2DM in patients with chronic hepatitis C, (ii) explore the effect of direct acting antivirals (DAA) treatment on the glycemia, and (iii) explore the factors that modulate the effect of DAA treatment on glycemia in patients with chronic hepatitis C. Methods: We performed a longitudinal retrospective observational study focused on the patients undergoing DAA treatment of chronic hepatitis C...
2018: Canadian Journal of Gastroenterology & Hepatology
En-Qiang Chen, Tetsuro Shimakami, Yu-Chen Fan, Paolo Angeli
No abstract text is available yet for this article.
2018: Canadian Journal of Gastroenterology & Hepatology
Ya-Xin Huang, Qi-Yi Zhao, Li-Li Wu, Dong-Ying Xie, Zhi-Liang Gao, Hong Deng
T follicular helper cells (Tfh cells) affect essential immune pathogenesis in chronic hepatitis B virus (HBV) infection. The CCR7lo PD-1hi Tfh subset has a partial Tfh effector phenotype and is associated with active Tfh differentiation, whereas the CCR7hi PD-1lo Tfh subset is a resting phenotype. We recruited 20 healthy volunteers and 77 patients with chronic HBV infection, including those in the immune tolerant (IT) phase (n=19), immune clearance (IC) phase (n=20), low replicative (LR) phase (n=18), and reactivation (RA) phase (n=20)...
2018: Canadian Journal of Gastroenterology & Hepatology
Samuel H Sigal, Alpesh Amin, Joseph A Chiodo, Arun Sanyal
Aim: Treatment practices and effectiveness in cirrhotic patients with hyponatremia (HN) in the HN Registry were assessed. Methods: Characteristics, treatments, and outcomes were compared between patients with HN at admission and during hospitalization. For HN at admission, serum sodium concentration [Na] response was analyzed until correction to > 130 mmol/L, switch to secondary therapy, or discharge or death with sodium ≤ 130 mmol/L. Results: Patients with HN at admission had a lower [Na] and shorter length of stay (LOS) than those who developed HN ( P < 0...
2018: Canadian Journal of Gastroenterology & Hepatology
Xi-Zhen Chen, Wei Kevin Zhang, He-Bin Tang, Xiao-Jun Li, Gui-Hua Tian, Hong-Cai Shang, Yu-Sang Li
Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice...
2018: Canadian Journal of Gastroenterology & Hepatology
Adeyinka Charles Adejumo, Oluwole Muyiwa Adegbala, Kelechi Lauretta Adejumo, Terence Ndonyi Bukong
Background and Aim: The effect of cannabis use on chronic liver disease (CLD) from Hepatitis C Virus (HCV) infection, the most common cause of CLD, has been controversial. Here, we investigated the impact of cannabis use on the prevalence of CLD among HCV infected individuals. Methods: We analyzed hospital discharge records of adults (age ≥ 18 years) with a positive HCV diagnosis. We evaluated records from 2007 to 2014 of the Nationwide Inpatient Sample (NIS)...
2018: Canadian Journal of Gastroenterology & Hepatology
Tommaso Stroffolini, Evangelista Sagnelli, Caterina Sagnelli, Filomena Morisco, Sergio Babudieri, Caterina Furlan, Mario Pirisi, Maurizio Russello, Antonina Smedile, Mariantonietta Pisaturo, Piero Luigi Almasio
Introduction: To evaluate the characteristics of alcohol-related chronic liver disease (CLD) in Italy and their potential changes over time. Patients and Methods: Subjects with CLD were enrolled in two national surveys performed in 2001 and in 2014 in Italy. The two surveys prospectively recruited patients aged ≥ 18 years referring to more than 80 Italian liver units scattered all over the country using similar clinical approach, analytical methods, and threshold of risky alcohol intake definition (≥ 3 units/day in men and ≥ 2 units/day in women)...
2018: Canadian Journal of Gastroenterology & Hepatology
Paule V Joseph, Sarah K Abey, Dan Wang, Nicolaas H Fourie, Natnael D Kenea, Tatyana G Vishnyakova, Jeffrey M Robinson, Kristen R Weaver, Christina M Boulineaux, Hannah R Davidson, LeeAnne B Sherwin, Onyinyechi Ozoji, Ana F Diallo, Paul A Smyser, Amy P Patterson, Wendy A Henderson
Background & Aims: Intestinal barrier alterations are associated with fatty liver (FL) and metabolic syndrome (MetS), but microRNA (miR) signaling pathways in MetS-FL pathogenesis remain unclear. This study investigates an epithelial-focused miR network in colorectal cell models based on the previously reported MetS-FL miR trio of hsa-miR-142-3p, hsa-miR-18b, and hsa-miR-890. Methods: Each miR mimic construct of MetS-FL miR trio was transfected into human colorectal cells, CRL-1790 or Caco-2...
2018: Canadian Journal of Gastroenterology & Hepatology
Gorkem Odabas, Metin Cetin, Serdar Turhal, Huseyin Baloglu, A Emre Sayan, Tamer Yagci
Background and Aims: Hepatocellular carcinoma is an aggressive malignancy of the liver and is ranked as the sixth most common cancer worldwide. There is still room for novel markers to improve the diagnosis and monitoring of HCC. Our observations in cancer databases that PLXNC1 is upregulated in HCC led us to investigate the expression profile of Plexin C1 mRNA and protein in HCC cell lines and tissues. Methods: A recombinant protein encompassing part of the extracellular domain of Plexin C1 was used as an antigen for monoclonal antibody development...
2018: Canadian Journal of Gastroenterology & Hepatology
Andrea Iannone, Marinella Ruospo, Germaine Wong, Michele Barone, Mariabeatrice Principi, Alfredo Di Leo, Giovanni F M Strippoli
Background: Diverticular disease treatment is limited to fibres, antibiotics, and surgery. There is conflicting evidence on mesalazine benefits and harms. Aim: We systematically reviewed current evidence on benefits and harms of mesalazine versus all other treatments in people with diverticular disease. Methods: We searched MEDLINE, EMBASE, CENTRAL, for studies published to July 2018. We estimated risk ratios (RR) for dichotomous outcomes (disease remission/recurrence, acute diverticulitis in symptomatic uncomplicated diverticular disease, need for surgery/hospitalization, all-cause/disease-related mortality, adverse events), mean differences (MD) or standardized MD (SMD) for continuous outcomes (quality of life, symptoms score, time to recurrence/remission), and their 95% confidence intervals (CI) using random-effects models...
2018: Canadian Journal of Gastroenterology & Hepatology
Zhang Hao, Zhu Biqing, Yang Ling, Zeng Wenting
This network analysis is to determine the most effective treatment in HBeAg-positive patients. PubMed databases were searched for randomized controlled trials. Bayesian network meta-analysis was used to calculate the pairwise hazard ratios, 95% credible intervals, and ranking of surrogate outcomes. 9 studies were identified. The results show that NA add-on PEG IFN might be a better antiviral approach for HBeAg-positive patients in end point of treatment, with a comparable results of nucleoside/nucleotide analogs (NA), PEG IFN, PEG IFN add-on NA, PEG IFN combined NA, and PEG IFN combined placebo in alanine aminotransferase (ALT) normalization and HBV DNA undetectable...
2018: Canadian Journal of Gastroenterology & Hepatology
Timna Naftali, Adi Eindor-Abarbanel, Nahum Ruhimovich, Ariella Bar-Gil Shitrit, Fabiana Sklerovsky-Benjaminov, Fred Konikoff, Shay Matalon, Haim Shirin, Yael Milgrom, Tomer Ziv-Baran, Efrat Broide
Introduction: Since individuals with IBD typically experience symptoms during their prime years of employment, it raises the question about IBD impact on employment status. Most studies concentrated on absenteeism from work with varying results in different populations. However, absenteeism reflects only one dimension of the ability to work and does not expose the problem of inability to hold a full-time job. Aims: To evaluate the influence of IBD on unemployment and working hours in Israel...
2018: Canadian Journal of Gastroenterology & Hepatology
Barry J Hall, P John Hamlin, David J Gracie, Alexander C Ford
Background and Aims: Mood may have an important role in the natural history of inflammatory bowel disease (IBD). However, the impact of antidepressant use on prognosis is unknown. We aimed to address this in a longitudinal study in a referral population. Methods: We collected demographic data, clinical disease activity and mood using validated questionnaires, and antidepressant use at baseline. Longitudinal disease activity was defined by disease flare or need for glucocorticosteroids, escalation of medical therapy, hospitalisation, or intestinal resection...
2018: Canadian Journal of Gastroenterology & Hepatology
Oluwaseun Shogbesan, Dilli Ram Poudel, Samjeris Victor, Asad Jehangir, Opeyemi Fadahunsi, Gbenga Shogbesan, Anthony Donato
Background: Fecal microbiota transplantation (FMT) has been shown to be effective in recurrent Clostridium difficile (CD) infection, with resolution in 80% to 90% of patients. However, immunosuppressed patients were often excluded from FMT trials, so safety and efficacy in this population are unknown. Methods: We searched MEDLINE and EMBASE for English language articles published on FMT for treatment of CD infection in immunocompromised patients (including patients on immunosuppressant medications, patients with human immunodeficiency virus (HIV), inherited or primary immunodeficiency syndromes, cancer undergoing chemotherapy, or organ transplant, including-bone marrow transplant) of all ages...
2018: Canadian Journal of Gastroenterology & Hepatology
Ozlem Kutlu, Humeyra Nur Kaleli, Ebru Ozer
The proportion of obese or diabetic population has been anticipated to increase in the upcoming decades, which rises the prevalence of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH). Recent evidence indicates that NASH is the main cause of chronic liver diseases and it is an important risk factor for development of hepatocellular carcinoma (HCC). Although the literature addressing NASH-HCC is growing rapidly, limited data is available about the etiology of NASH-related HCC...
2018: Canadian Journal of Gastroenterology & Hepatology
Sanda Mustapic, Sead Ziga, Vladimir Matic, Tomislav Bokun, Bozo Radic, Marko Lucijanic, Srecko Marusic, Zarko Babic, Ivica Grgurevic
The aim of the study was to explore (a) prevalence and grade of nonalcoholic fatty liver (NAFL) among outpatients referred for abdominal ultrasound (US) examination and (b) relationship between the presence and severity of liver steatosis and metabolic syndrome (MS). This was a retrospective analysis of patients without history of liver disease examined by abdominal US in the University hospital setting. US was used to detect and semiquantitatively grade (0-3) liver steatosis. Data on patients' age, gender, body mass index (BMI), impaired glucose metabolism (IGM), atherogenic dyslipidaemia (AD), raised blood pressure (RBP), transaminases, and platelet counts were obtained from medical records...
2018: Canadian Journal of Gastroenterology & Hepatology
Mohammad Golriz, Elias Khajeh, Omid Ghamarnejad, Arianeb Mehrabi
No abstract text is available yet for this article.
2018: Canadian Journal of Gastroenterology & Hepatology
Feiyue Zhang, Tong Liu, Pan Gao, Sujuan Fei
Objective: In recent years, the noninvasive serological scoring system has become a research hotspot in predicting hepatic fibrosis and has achieved good results. However, it has rarely been applied to the prediction of oesophageal varices. The aim of the study was to evaluate the predictive value of the four following scoring systems in cirrhosis combined with oesophageal varices: aspartate and platelet ratio index (APRI), aspartate aminotransferase-alanine aminotransferase ratio (AAR), FIB-4, and S index...
2018: Canadian Journal of Gastroenterology & Hepatology
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