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Canadian Journal of Gastroenterology & Hepatology

Lan Dam, Anita Cheng, Phuong Tran, Shirley S Wong, Ronald Hershow, Sheldon Cotler, Scott J Cotler
Stigma regarding viral hepatitis and liver disease has psychological and social consequences including causing negative self-image, disrupting relationships, and providing a barrier to prevention, testing, and treatment. The aim of this study was to characterize and compare HBV knowledge and stigma in Vietnamese in Ho Chi Minh City and Chicago and to begin to evaluate the cultural context of HBV stigma. Methods. A written survey including knowledge questions and a validated HBV stigma questionnaire was distributed to Vietnamese in Ho Chi Minh City and Chicago...
2016: Canadian Journal of Gastroenterology & Hepatology
Ravi Misra, Alan Askari, Omar Faiz, Naila Arebi
Introduction. Previous epidemiological studies suggest a higher rate of pancolonic disease in South Asians (SA) compared with White Europeans (WE). The aim of the study was to compare colectomy rates for ulcerative colitis (UC) in SA to those of WE. Methods. Patients with UC were identified from a national administrative dataset (Hospital Episode Statistics, HES) between 1997 and 2012 according to ICD-10 diagnosis code K51 for UC. The colectomy rate for each ethnic group was calculated as the proportion of patients who underwent colectomy from the total UC cases for that group...
2016: Canadian Journal of Gastroenterology & Hepatology
Carol Lam, Robert Bandsma, Simon Ling, Marialena Mouzaki
Objective. Adult data suggest that frequent monitoring of patients with nonalcoholic fatty liver disease (NAFLD) may be associated with improved outcomes. The optimal frequency of outpatient visits for the management of pediatric NAFLD remains unknown. Study Design. In this retrospective study, two cohorts of patients with NAFLD, one followed on a yearly basis and one followed on 3-month intervals, were included. Both received similar advice regarding lifestyle changes. Primary outcome was change in BMI z-scores over a year...
2016: Canadian Journal of Gastroenterology & Hepatology
Alghalya Khalid Sulaiman Al-Maawali, Phuong Nguyen, P Terry Phang
Crohn's disease (CD) is a complex disorder with important incidence in North America. Perianal fistulas occur in about 20% of patients with CD and are almost always classified as complex fistulas. Conventional treatment options have shown different success rates, yet there are data indicating that these approaches cannot achieve total cure and may not improve quality of life of these patients. Fibrin glue, fistula plug, topical tacrolimus, local injection of infliximab, and use of hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) are newly suggested therapies with variable success rates...
2016: Canadian Journal of Gastroenterology & Hepatology
Sarvenaz Moosavi, Robert Enns, Laura Gentile, Lovedeep Gondara, Colleen McGahan, Jennifer Telford
Objective. To determine the positive predictive value (PPV) of two versus one abnormal FIT in the detection of colorectal neoplasia in a Canadian population. Methods. Three communities enrolled in a colorectal cancer (CRC) screening pilot program from 01/2009 to 04/2013 using 2 FITs. Data collected included demographics, colonoscopy, pathology, and FIT results. Participants completed both FITs and had one positive FIT and colonoscopy. PPV of one versus two abnormal FITs was calculated using a weighted-generalized score statistic...
2016: Canadian Journal of Gastroenterology & Hepatology
Dietmar Enko, Andreas Meinitzer, Harald Mangge, Gernot Kriegshäuser, Gabriele Halwachs-Baumann, Eva Z Reininghaus, Susanne A Bengesser, Wolfgang J Schnedl
The aim of this retrospective study was to analyze the concomitant prevalence rates for lactose malabsorption (LM), fructose malabsorption (FM), and histamine intolerance (HI) in patients with so far unexplained gastrointestinal (GI) symptoms. A total of 439 outpatients, who presented unclear abdominal discomfort, underwent lactose (50 g) and fructose (25 g) hydrogen (H2) breath tests. Additionally, serum diamine oxidase (DAO) measurements were performed. Individuals with low serum DAO activity (<10 U/mL), GI symptoms, and response to histamine-free diet were diagnosed with HI...
2016: Canadian Journal of Gastroenterology & Hepatology
Xiulan Xue, Shaohang Cai
No abstract text is available yet for this article.
2016: Canadian Journal of Gastroenterology & Hepatology
Hari Padmanabhan, Alexander Rothnie, Andy Higgins, Amandeep Grewal, Katherine Arndtz, Alan M Nevill, Matthew J Brookes, Ray Mathew
Aim. To determine whether preassessment improves bowel preparation quality and prevents renal deterioration for chronic kidney disease (CKD) patients. Methods. Data was collected prospectively starting in January 2011 for 12 months. Patients were divided according to the presence or absence of preassessment and stratified to one of three risk groups based on patient's comorbidities and identified risk factors for poor bowel preparation; group 1 had no risk factors, group 2 had 1 risk factor, and group 3 patients had 2 or more risk factors...
2016: Canadian Journal of Gastroenterology & Hepatology
Nadav Willner, Maya Peled-Raz, Dan Shteinberg, Michal Shteinberg, Dean Keren, Tova Rainis
Aims and Methods. Conducting a survey study of a large number of patients and gastroenterologists aimed at identifying relevant predictors of interest in digital recording and documentation (DRD) of endoscopic procedures. Outpatients presenting to the endoscopy unit at our institution for an endoscopy examination were anonymously surveyed, regarding their views and opinions of a possible recording of the procedure. A parallel survey for gastroenterologists was conducted. Results. 417 patients and 62 gastroenterologists participated in two parallel surveys regarding DRD of endoscopic procedures...
2016: Canadian Journal of Gastroenterology & Hepatology
Nwe Ni Than, Hannah C Jeffery, Ye H Oo
[This corrects the article DOI: 10.1155/2016/7181685.].
2016: Canadian Journal of Gastroenterology & Hepatology
Robert A Mitchell, Constantin Shuster, Neal Shahidi, Cherry Galorport, Mari L DeMarco, Gregory Rosenfeld, Robert A Enns, Brian Bressler
Background. Infliximab (IFX) therapeutic drug monitoring (TDM) allows for objective decision making in patients with inflammatory bowel disease (IBD) and loss of response. Questions remain about whether IFX TDM improves outcomes. Methods. Patients with IBD who had IFX TDM due to concerns for loss of response were considered for inclusion. Serum IFX trough concentration and anti-drug antibody (ADA) concentrations were measured. Patients were grouped by TDM results: group 1, low IFX/high ADA; group 2, low IFX/low ADA; group 3, therapeutic IFX...
2016: Canadian Journal of Gastroenterology & Hepatology
Kevin Waschke, Karen Sparkes
No abstract text is available yet for this article.
2016: Canadian Journal of Gastroenterology & Hepatology
Ana C Caetano, André Santa-Cruz, Carla Rolanda
Background. Rome III criteria add physiological criteria to symptom-based criteria of chronic constipation (CC) for the diagnosis of defecatory disorders (DD). However, a gold-standard test is still lacking and physiological examination is expensive and time-consuming. Aim. Evaluate the usefulness of two low-cost tests-digital rectal examination (DRE) and balloon expulsion test (BET)-as screening or excluding tests of DD. Methods. We performed a systematic search in PUBMED and MEDLINE. We selected studies where constipated patients were evaluated by DRE or BET...
2016: Canadian Journal of Gastroenterology & Hepatology
Nicholas van Buuren, Lorraine Fradette, Jason Grebely, Alexandra King, Mel Krajden, Sonya A MacParland, Alison Marshall, Sahar Saeed, Joyce Wilson, Marina B Klein, Selena M Sagan
Hepatitis C virus (HCV) affects approximately 268,000 Canadians and results in more years of life lost than any other infectious disease in the country. Both the Canadian Institutes of Health Research (CIHR) and the Public Health Agency of Canada (PHAC) have identified HCV-related liver disease as a priority and supported the establishment of a National Hepatitis C Research Network. In 2015, the introduction of new interferon- (IFN-) free therapies with high cure rates (>90%) and few side effects revolutionized HCV therapy...
2016: Canadian Journal of Gastroenterology & Hepatology
Stéphanie Carpentier, Nour Sharara, Alan N Barkun, Sara El Ouali, Myriam Martel, Maida J Sewitch
Background. The United Kingdom Global Rating Scale (GRS-UK) measures unit-level quality metrics processes in digestive endoscopy. We evaluated the psychometric properties of its Canadian version (GRS-C), endorsed by the Canadian Association of Gastroenterology (CAG). Methods. Prospective data collection at three Canadian endoscopy units assessed GRS-C validity, reliability, and responsiveness to change according to responses provided by physicians, endoscopy nurses, and administrative personnel. These responses were compared to national CAG endoscopic quality guidelines and GRS-UK statements...
2016: Canadian Journal of Gastroenterology & Hepatology
Faisal Al Shatti, Vladimir Marquez Azalagara, Eric M Yoshida
No abstract text is available yet for this article.
2016: Canadian Journal of Gastroenterology & Hepatology
Kook Hyun Kim, Tae Nyeun Kim
Objective. Bile duct stone-related adverse events can be detrimental in the elderly. However, little is known about clinical outcomes and adverse events following endoscopic papillary large balloon dilation (EPLBD) in the elderly. The aim of this study was to evaluate the safety and feasibility of EPLBD for the removal of CBD stones in patients aged ≥ 80 years. Methods. A total of 204 patients who underwent EPLBD from 2006 to 2012 were retrospectively reviewed. Patients were classified into two groups (148 patients < 80 years old, Group A; 56 patients ≥ 80 years old, Group B)...
2016: Canadian Journal of Gastroenterology & Hepatology
Yuto Shimamura, Niroshan Muwanwella, Sujievvan Chandran, Gabor Kandel, Norman Marcon
Clinicians can be forgiven for thinking of anisakiasis as a rare condition low in the differential diagnosis of abdominal pain. Gastrointestinal anisakiasis is a zoonotic parasitic disease caused by consumption of raw or undercooked seafood infected with nematodes of the genus Anisakis. Even though the reported cases indicate that this is a rare disease, the true incidence of the disease could be potentially higher than what is reported in the literature as cases can go undiagnosed. Diagnosis and treatment of gastric anisakiasis are made by a compatible dietary history, direct visualization, and removal of the larvae via gastroscopy...
2016: Canadian Journal of Gastroenterology & Hepatology
Matthew T Bernstein, Laura E Targownik, Kathryn A Sexton, Lesley A Graff, Norine Miller, John R Walker
Objective. To describe the sources of stress for persons with IBD and changes with changes in symptoms. Methods. 487 participants were recruited from a population-based IBD registry. Stress was measured at study entry and three months later, using a general stress measure and the Sources of Stress Scale. Four symptom pattern groups were identified: persistently inactive, persistently active, inactive to active, and active to inactive. Results. General stress levels were stable within each symptom pattern group over the three-month period, even for those with changing symptom activity...
2016: Canadian Journal of Gastroenterology & Hepatology
Candace L Beilman, Nguyen Xuan Thanh, Victoria Ung, Christopher Ma, Karen Wong, Karen I Kroeker, Thomas Lee, Haili Wang, Arto Ohinmaa, Phil Jacobs, Brendan P Halloran, Richard N Fedorak
Background. Adalimumab is effective for the maintenance of remission in patients with moderate-to-severe ulcerative colitis (UC). Currently, biologic therapies are used in cases where patients fail conventional medical therapies. If biologic therapies are not available, patients often choose to remain in an unwell state rather than undergo colectomy. Objective. The aim of the study was to evaluate the cost-effectiveness of adalimumab in patients with UC where adalimumab was readily available compared to not available...
2016: Canadian Journal of Gastroenterology & Hepatology
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