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Canadian Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28321390/metabonomics-research-progress-on-liver-diseases
#1
REVIEW
Mengqian Yu, Ying Zhu, Qingwei Cong, Chunyan Wu
Metabolomics as the new omics technique develops after genomics, transcriptomics, and proteomics and has rapid development at present. Liver diseases are worldwide public health problems. In China, chronic hepatitis B and its secondary diseases are the common liver diseases. They can be diagnosed by the combination of history, virology, liver function, and medical imaging. However, some patients seldom have relevant physical examination, so the diagnosis may be delayed. Many other liver diseases, such as drug-induced liver injury (DILI), alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD), and autoimmune liver diseases, still do not have definite diagnostic markers; the diagnosis consists of history, medical imaging, and the relevant score...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28280718/response-to-comment-on-assessment-of-liver-stiffness-in-pediatric-fontan-patients-using-transient-elastography
#2
COMMENT
Becky Chen, Richard A Schreiber, Derek G Human, James E Potts, Orlee R Guttman
No abstract text is available yet for this article.
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28271055/treatment-algorithm-for-chronic-idiopathic-constipation-and-constipation-predominant-irritable-bowel-syndrome-derived-from-a-canadian-national-survey-and-needs-assessment-on-choices-of-therapeutic-agents
#3
Yvonne Tse, David Armstrong, Christopher N Andrews, Alain Bitton, Brian Bressler, John Marshall, Louis W C Liu
Background. Chronic idiopathic constipation (CIC) and constipation-predominant irritable bowel syndrome (IBS-C) are common functional lower gastrointestinal disorders that impair patients' quality of life. In a national survey, we aimed to evaluate (1) Canadian physician practice patterns in the utilization of therapeutic agents listed in the new ACG and AGA guidelines; (2) physicians satisfaction with these agents for their CIC and IBS-C patients; and (3) the usefulness of these new guidelines in their clinical practice...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28265555/aseptic-abscesses-and-inflammatory-bowel-disease-two-cases-and-review-of-literature
#4
REVIEW
Natasha Bollegala, Rishad Khan, Michael A Scaffidi, Ahmed Al-Mazroui, Jenna Tessolini, Adrienne Showler, Errol Colak, Samir C Grover
Background. Aseptic abscesses (AA) are sterile lesions that represent an extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Though Canada has the highest prevalence of IBD in the world, reports of IBD-associated AA are absent in Canada. This may represent a different IBD phenotype or underrecognition and underreporting. Purpose. To explore AA as a possible EIM of IBD and evaluate clinical and investigative findings among patients with IBD-associated AA. Methods. Retrospective chart and literature reviews were performed to find cases of IBD-associated AA at our institution and in the literature...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28239601/public-versus-private-drug-insurance-and-outcomes-of-patients-requiring-biologic-therapies-for-inflammatory-bowel-disease
#5
COMPARATIVE STUDY
Amir Rumman, Roberto Candia, Justina J Sam, Kenneth Croitoru, Mark S Silverberg, A Hillary Steinhart, Geoffrey C Nguyen
Background. Antitumor necrosis factor (anti-TNF) therapy is a highly effective but costly treatment for inflammatory bowel disease (IBD). Methods. We conducted a retrospective cohort study of IBD patients who were prescribed anti-TNF therapy (2007-2014) in Ontario. We assessed if the insurance type was a predictor of timely access to anti-TNF therapy and nonroutine health utilization (emergency department visits and hospitalizations). Results. There were 268 patients with IBD who were prescribed anti-TNF therapy...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28194394/assessment-of-school-readiness-in-chronic-cholestatic-liver-disease-a-pilot-study-examining-children-with-and-without-liver-transplantation
#6
Anna Gold, Alaine Rogers, Elizabeth Cruchley, Stephanie Rankin, Arpita Parmar, Binita M Kamath, Yaron Avitzur, Vicky Lee Ng
Background. Assessment of school readiness evaluates physical, social-emotional, and neuropsychological domains essential for educational success. Cognitive testing of preschool aged children with chronic liver disease may guide more timely interventions and focused efforts by health care providers. Patients and Methods. Children with chronic cholestatic liver disease diagnosed as an infant and still with their native liver (NL) and children who received a liver transplant (LT) before age of 2 years underwent testing with a battery of well-validated pediatric psychometric measures...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28191453/anti-tnf-mediated-modulation-of-prohepcidin-improves-iron-availability-in-inflammatory-bowel-disease-in-an-il-6-mediated-fashion
#7
Flaminia Cavallaro, Lorena Duca, Laura Francesca Pisani, Roberta Rigolini, Luisa Spina, Gian Eugenio Tontini, Nadia Munizio, Elena Costa, Maria Domenica Cappellini, Maurizio Vecchi, Luca Pastorelli
Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and of anaemia of chronic disease (ACD). ACD is characterized by macrophage iron retention induced by proinflammatory cytokines. Hepcidin is the master inducer of iron accumulation during ACD, and its production is mainly regulated by IL-6 and the novel erythroid hormone erythroferrone (ERFE). This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin production and the levels of its main regulators, leading to a restoration of iron homeostasis...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28182112/prevalence-and-anatomic-distribution-of-serrated-and-adenomatous-lesions-in-patients-with-inflammatory-bowel-disease
#8
Lik Hang Lee, Marietta Iacucci, Miriam Fort Gasia, Subrata Ghosh, Remo Panaccione, Stefan Urbanski
Background. Sessile serrated adenomas/polyps (SSA/Ps) and traditional serrated adenomas (TSAs) have not been well characterized in patients with inflammatory bowel disease (IBD). This study assesses the prevalence and anatomic distribution of SSA/Ps, TSAs, and conventional adenomas/dysplasia (Ad/Ds) in IBD patients. Methods. IBD patients with serrated, adenomatous, or hyperplastic lesions between 2005 and 2009 were identified in the regional tertiary-care hospital database. Clinicopathological information was reviewed and the histology of biopsies was reevaluated...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28164081/grazoprevir-and-elbasvir-in-patients-with-genotype-1-hepatitis-c-virus-infection-a-comprehensive-efficacy-and-safety-analysis
#9
Yinan Yao, Ming Yue, Jie Wang, Hongbo Chen, Mei Liu, Feng Zang, Jun Li, Yun Zhang, Peng Huang, Rongbin Yu
Background. It is urgent for patients with hepatitis C virus (HCV) infection to find a safe, effective, and interferon-free regimen to optimize therapy. A comprehensive analysis was performed to evaluate the efficacy and safety of the grazoprevir combined with elbasvir, with or without ribavirin (RBV), in 777 treatment-naive and treatment-experienced patients with HCV genotype 1 infection from 3 randomized controlled trials (RCTs). Method. We collected data from the following trials: C-WORTHY (NCT01717326), C-SALVAGE (NCT02105454), and C-EDGE (NCT02105467)...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28127545/advanced-hepatic-fibrosis-in-fatty-liver-disease-linked-to-hyperplastic-colonic-polyp
#10
Mahmud Mahamid, Omar Abu-Elhija, Tarik Yassin, William Nseir
Aim. Our study aims to determine possible association between biopsy-proven nonalcoholic steatohepatitis (NASH) and hyperplastic polyps (HP) of the colon. Methods. A retrospective cohort observational study. All subjects underwent screening colonoscopy within two years. Data were extracted from the patient charts including demographic, anthropometric measurement, vital signs, underlying diseases, medical therapy, laboratory data, results of the liver biopsy with degree of fibrosis and necroinflammatory activity, the colonoscopy report, and the pathological report of the extracted polyp...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28116286/correlating-quantitative-fecal-immunochemical-test-results-with-neoplastic-findings-on-colonoscopy-in-a-population-based-colorectal-cancer-screening-program-a-prospective-study
#11
Neal Shahidi, Laura Gentile, Lovedeep Gondara, Jeremy Hamm, Colleen E McGahan, Robert Enns, Jennifer Telford
Background and Aims. The Canadian Partnership Against Cancer (CPAC) recommends a fecal immunochemical test- (FIT-) positive predictive value (PPV) for all adenomas of ≥50%. We sought to assess FIT performance among average-risk participants of the British Columbia Colon Screening Program (BCCSP). Methods. From Nov-2013 to Dec-2014 consecutive participants of the BCCSP were assessed. Data was obtained from a prospectively collected database. A single quantitative FIT (NS-Plus, Alfresa Pharma Corporation, Japan) with a cut-off of ≥10 μg/g (≥50 ng/mL) was used...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28116285/changes-in-cardiac-varices-and-their-clinical-significance-after-eradication-of-esophageal-varices-by-band-ligation
#12
Seung Woon Park, Yeon Seok Seo, Han Ah Lee, Sang Jung Park, Tae Hyung Kim, Jae Min Lee, Sang Jun Suh, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Young Kul Jung, Ji Hoon Kim, Hyonggin An, Hyung Joon Yim, Yoon Tae Jeen, Jong Eun Yeon, Hong Sik Lee, Hoon Jai Chun, Kwan Soo Byun, Soon Ho Um, Chang Duck Kim
Background and Aims. Cardiac varices (CVs) in patients with type 1 gastroesophageal varices (GOV1s) usually disappear with treatment for esophageal varices (EVs) by endoscopic injection sclerotherapy (EIS). However, whether this applies to patients treated with endoscopic band ligation (EBL) for EVs remains unclear. We evaluated the effect of EVs eradication by EBL on CVs. Methods. We included cirrhotic patients whose EVs had been eradicated using EBL and excluded those who had been treated using EIS, those who had received endoscopic therapy for CVs, and those who were combined with hepatocellular carcinoma...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28101498/hepatitis-b-stigma-and-knowledge-among-vietnamese-in-ho-chi-minh-city-and-chicago
#13
Lan Dam, Anita Cheng, Phuong Tran, Shirley S Wong, Ronald Hershow, Sheldon Cotler, Scott J Cotler
Stigma regarding viral hepatitis and liver disease has psychological and social consequences including causing negative self-image, disrupting relationships, and providing a barrier to prevention, testing, and treatment. The aim of this study was to characterize and compare HBV knowledge and stigma in Vietnamese in Ho Chi Minh City and Chicago and to begin to evaluate the cultural context of HBV stigma. Methods. A written survey including knowledge questions and a validated HBV stigma questionnaire was distributed to Vietnamese in Ho Chi Minh City and Chicago...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28074174/colectomy-rates-for-ulcerative-colitis-differ-between-ethnic-groups-results-from-a-15-year-nationwide-cohort-study
#14
Ravi Misra, Alan Askari, Omar Faiz, Naila Arebi
Introduction. Previous epidemiological studies suggest a higher rate of pancolonic disease in South Asians (SA) compared with White Europeans (WE). The aim of the study was to compare colectomy rates for ulcerative colitis (UC) in SA to those of WE. Methods. Patients with UC were identified from a national administrative dataset (Hospital Episode Statistics, HES) between 1997 and 2012 according to ICD-10 diagnosis code K51 for UC. The colectomy rate for each ethnic group was calculated as the proportion of patients who underwent colectomy from the total UC cases for that group...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28058253/more-frequent-clinic-visits-are-associated-with-improved-outcomes-for-children-with-nafld
#15
Carol Lam, Robert Bandsma, Simon Ling, Marialena Mouzaki
Objective. Adult data suggest that frequent monitoring of patients with nonalcoholic fatty liver disease (NAFLD) may be associated with improved outcomes. The optimal frequency of outpatient visits for the management of pediatric NAFLD remains unknown. Study Design. In this retrospective study, two cohorts of patients with NAFLD, one followed on a yearly basis and one followed on 3-month intervals, were included. Both received similar advice regarding lifestyle changes. Primary outcome was change in BMI z-scores over a year...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28053967/modern-treatments-and-stem-cell-therapies-for-perianal-crohn-s-fistulas
#16
REVIEW
Alghalya Khalid Sulaiman Al-Maawali, Phuong Nguyen, P Terry Phang
Crohn's disease (CD) is a complex disorder with important incidence in North America. Perianal fistulas occur in about 20% of patients with CD and are almost always classified as complex fistulas. Conventional treatment options have shown different success rates, yet there are data indicating that these approaches cannot achieve total cure and may not improve quality of life of these patients. Fibrin glue, fistula plug, topical tacrolimus, local injection of infliximab, and use of hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) are newly suggested therapies with variable success rates...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28044123/comparison-of-one-versus-two-fecal-immunochemical-tests-in-the-detection-of-colorectal-neoplasia-in-a-population-based-colorectal-cancer-screening-program
#17
COMPARATIVE STUDY
Sarvenaz Moosavi, Robert Enns, Laura Gentile, Lovedeep Gondara, Colleen McGahan, Jennifer Telford
Objective. To determine the positive predictive value (PPV) of two versus one abnormal FIT in the detection of colorectal neoplasia in a Canadian population. Methods. Three communities enrolled in a colorectal cancer (CRC) screening pilot program from 01/2009 to 04/2013 using 2 FITs. Data collected included demographics, colonoscopy, pathology, and FIT results. Participants completed both FITs and had one positive FIT and colonoscopy. PPV of one versus two abnormal FITs was calculated using a weighted-generalized score statistic...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28042564/concomitant-prevalence-of-low-serum-diamine-oxidase-activity-and-carbohydrate-malabsorption
#18
Dietmar Enko, Andreas Meinitzer, Harald Mangge, Gernot Kriegshäuser, Gabriele Halwachs-Baumann, Eva Z Reininghaus, Susanne A Bengesser, Wolfgang J Schnedl
The aim of this retrospective study was to analyze the concomitant prevalence rates for lactose malabsorption (LM), fructose malabsorption (FM), and histamine intolerance (HI) in patients with so far unexplained gastrointestinal (GI) symptoms. A total of 439 outpatients, who presented unclear abdominal discomfort, underwent lactose (50 g) and fructose (25 g) hydrogen (H2) breath tests. Additionally, serum diamine oxidase (DAO) measurements were performed. Individuals with low serum DAO activity (<10 U/mL), GI symptoms, and response to histamine-free diet were diagnosed with HI...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28025635/comment-on-assessment-of-liver-stiffness-in-pediatric-fontan-patients-using-transient-elastography
#19
COMMENT
Xiulan Xue, Shaohang Cai
No abstract text is available yet for this article.
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28018894/preassessment-interview-improves-the-efficacy-and-safety-of-bowel-preparation-for-colonoscopy
#20
Hari Padmanabhan, Alexander Rothnie, Andy Higgins, Amandeep Grewal, Katherine Arndtz, Alan M Nevill, Matthew J Brookes, Ray Mathew
Aim. To determine whether preassessment improves bowel preparation quality and prevents renal deterioration for chronic kidney disease (CKD) patients. Methods. Data was collected prospectively starting in January 2011 for 12 months. Patients were divided according to the presence or absence of preassessment and stratified to one of three risk groups based on patient's comorbidities and identified risk factors for poor bowel preparation; group 1 had no risk factors, group 2 had 1 risk factor, and group 3 patients had 2 or more risk factors...
2016: Canadian Journal of Gastroenterology & Hepatology
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