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Canadian Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/27867932/2016-canadian-association-of-gastroenterology-educational-needs-assessment-report
#1
EDITORIAL
Kevin Waschke, Karen Sparkes
No abstract text is available yet for this article.
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27847802/digital-rectal-examination-and-balloon-expulsion-test-in-the-study-of-defecatory-disorders-are-they-suitable-as-screening-or-excluding-tests
#2
REVIEW
Ana C Caetano, André Santa-Cruz, Carla Rolanda
Background. Rome III criteria add physiological criteria to symptom-based criteria of chronic constipation (CC) for the diagnosis of defecatory disorders (DD). However, a gold-standard test is still lacking and physiological examination is expensive and time-consuming. Aim. Evaluate the usefulness of two low-cost tests-digital rectal examination (DRE) and balloon expulsion test (BET)-as screening or excluding tests of DD. Methods. We performed a systematic search in PUBMED and MEDLINE. We selected studies where constipated patients were evaluated by DRE or BET...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27843889/the-5th-canadian-symposium-on-hepatitis-c-virus-we-are-not-done-yet-remaining-challenges-in-hepatitis-c
#3
Nicholas van Buuren, Lorraine Fradette, Jason Grebely, Alexandra King, Mel Krajden, Sonya A MacParland, Alison Marshall, Sahar Saeed, Joyce Wilson, Marina B Klein, Selena M Sagan
Hepatitis C virus (HCV) affects approximately 268,000 Canadians and results in more years of life lost than any other infectious disease in the country. Both the Canadian Institutes of Health Research (CIHR) and the Public Health Agency of Canada (PHAC) have identified HCV-related liver disease as a priority and supported the establishment of a National Hepatitis C Research Network. In 2015, the introduction of new interferon- (IFN-) free therapies with high cure rates (>90%) and few side effects revolutionized HCV therapy...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27840810/pilot-validation-study-canadian-global-rating-scale-for-colonoscopy-services
#4
Stéphanie Carpentier, Nour Sharara, Alan N Barkun, Sara El Ouali, Myriam Martel, Maida J Sewitch
Background. The United Kingdom Global Rating Scale (GRS-UK) measures unit-level quality metrics processes in digestive endoscopy. We evaluated the psychometric properties of its Canadian version (GRS-C), endorsed by the Canadian Association of Gastroenterology (CAG). Methods. Prospective data collection at three Canadian endoscopy units assessed GRS-C validity, reliability, and responsiveness to change according to responses provided by physicians, endoscopy nurses, and administrative personnel. These responses were compared to national CAG endoscopic quality guidelines and GRS-UK statements...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27818988/academic-outcomes-and-utility-of-gastroenterology-residents-in-training-course-abstract-presentations-the-university-of-british-columbia-experience
#5
Faisal Al Shatti, Vladimir Marquez Azalagara, Eric M Yoshida
No abstract text is available yet for this article.
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27812520/efficacy-and-safety-of-endoscopic-papillary-large-balloon-dilation-for-removal-of-large-bile-duct-stones-in-advanced-age
#6
Kook Hyun Kim, Tae Nyeun Kim
Objective. Bile duct stone-related adverse events can be detrimental in the elderly. However, little is known about clinical outcomes and adverse events following endoscopic papillary large balloon dilation (EPLBD) in the elderly. The aim of this study was to evaluate the safety and feasibility of EPLBD for the removal of CBD stones in patients aged ≥ 80 years. Methods. A total of 204 patients who underwent EPLBD from 2006 to 2012 were retrospectively reviewed. Patients were classified into two groups (148 patients < 80 years old, Group A; 56 patients ≥ 80 years old, Group B)...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27800471/common-symptoms-from-an-uncommon-infection-gastrointestinal-anisakiasis
#7
REVIEW
Yuto Shimamura, Niroshan Muwanwella, Sujievvan Chandran, Gabor Kandel, Norman Marcon
Clinicians can be forgiven for thinking of anisakiasis as a rare condition low in the differential diagnosis of abdominal pain. Gastrointestinal anisakiasis is a zoonotic parasitic disease caused by consumption of raw or undercooked seafood infected with nematodes of the genus Anisakis. Even though the reported cases indicate that this is a rare disease, the true incidence of the disease could be potentially higher than what is reported in the literature as cases can go undiagnosed. Diagnosis and treatment of gastric anisakiasis are made by a compatible dietary history, direct visualization, and removal of the larvae via gastroscopy...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27795954/assessing-the-relationship-between-sources-of-stress-and-symptom-changes-among-persons-with-ibd-over-time-a-prospective-study
#8
Matthew T Bernstein, Laura E Targownik, Kathryn A Sexton, Lesley A Graff, Norine Miller, John R Walker
Objective. To describe the sources of stress for persons with IBD and changes with changes in symptoms. Methods. 487 participants were recruited from a population-based IBD registry. Stress was measured at study entry and three months later, using a general stress measure and the Sources of Stress Scale. Four symptom pattern groups were identified: persistently inactive, persistently active, inactive to active, and active to inactive. Results. General stress levels were stable within each symptom pattern group over the three-month period, even for those with changing symptom activity...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27781203/real-life-treatment-paradigms-show-adalimumab-is-cost-effective-for-the-management-of-ulcerative-colitis
#9
Candace L Beilman, Nguyen Xuan Thanh, Victoria Ung, Christopher Ma, Karen Wong, Karen I Kroeker, Thomas Lee, Haili Wang, Arto Ohinmaa, Phil Jacobs, Brendan P Halloran, Richard N Fedorak
Background. Adalimumab is effective for the maintenance of remission in patients with moderate-to-severe ulcerative colitis (UC). Currently, biologic therapies are used in cases where patients fail conventional medical therapies. If biologic therapies are not available, patients often choose to remain in an unwell state rather than undergo colectomy. Objective. The aim of the study was to evaluate the cost-effectiveness of adalimumab in patients with UC where adalimumab was readily available compared to not available...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27777925/the-effect-of-bariatric-surgery-on-the-spectrum-of-fatty-liver-disease
#10
Jordan J Nostedt, Noah J Switzer, Richdeep S Gill, Jerry Dang, Daniel W Birch, Christopher de Gara, Robert J Bailey, Shahzeer Karmali
Nonalcoholic fatty liver disease is becoming one of the most common causes of liver disease in the western world. The most significant risk factors are obesity and the metabolic syndrome for which bariatric surgery has been shown to be an effective treatment. However, the effects of bariatric surgery on nonalcoholic fatty liver disease, specifically liver fibrosis and cirrhosis, are not well established. We review published bariatric surgery outcomes with respect to nonalcoholic liver disease. On the basis of this review we suggest that bariatric surgery may provide a viable treatment option for the treatment of nonalcoholic fatty liver disease, including patients with fibrosis and compensated cirrhosis, and that this topic should be a target of future investigation...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27774443/the-utility-of-fecal-calprotectin-in-the-real-world-clinical-care-of-patients-with-inflammatory-bowel-disease
#11
Esmail Abej, Wael El-Matary, Harminder Singh, Charles N Bernstein
Objectives. To determine the relationship between fecal calprotectin (FCAL) and imaging studies and other biochemical inflammatory markers and the impact of FCAL measurements on decision-making in IBD patient management in usual clinical practice. Methods. 240 persons with IBD were enrolled. The correlation between FCAL values and other markers for disease activity such as serum albumin (alb), hemoglobin (Hg), and C-reactive protein (CRP) and diagnostic imaging or colonoscopy was examined. FCAL ≥ 250 mcg/g of stool was considered a positive result indicating active IBD...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27725926/management-of-inflammatory-bowel-disease-during-pregnancy-and-breastfeeding-varies-widely-a-need-for-further-education
#12
Vivian Wai-Mei Huang, Hsiu-Ju Chang, Karen Ivy Kroeker, Karen Jean Goodman, Kathleen M Hegadoren, Levinus Albert Dieleman, Richard Neil Fedorak
Background. Inflammatory bowel disease (IBD) affects patients in their young reproductive years. Women with IBD require maintenance therapies during pregnancy and breastfeeding. However, physician management of IBD during pregnancy and breastfeeding has not been well characterized. Objective. To characterize physician perceptions and management of IBD during pregnancy and breastfeeding. Methods. A cross-sectional survey of Canadian physicians who are involved in the care of women with IBD was conducted. The survey included multiple-choice and Likert scale questions about perceptions and practice patterns regarding the management of IBD during pregnancy and breastfeeding...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27725925/examination-of-physicians-perception-of-the-indications-of-colorectal-stents-in-the-management-of-malignant-large-bowel-obstruction-a-provincial-survey
#13
Jean-Frédéric LeBlanc, Myriam Martel, Alan N Barkun
Introduction. Data are conflicting when assessing indications for colorectal self-expandable metallic stents (SEMS) in managing acute malignant large bowel obstruction (MLO). In November 2014, European and American Societies published guidelines to aid in understanding which patients might benefit from colorectal stenting. Yet, there remain marked disparities in clinical practice. Methods. A web-based survey was sent to Gastroenterologists and Surgical Specialists across Quebec to assess physicians' knowledge and adherence to the indications for colonic SEMS placement in the management of MLO using eight clinical scenarios...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27722149/how-to-make-feedback-more-effective-qualitative-findings-from-pilot-testing-of-an-audit-and-feedback-report-for-endoscopists
#14
Fiona Webster, Jigisha Patel, Kathleen Rice, Nancy Baxter, Lawrence Paszat, Linda Rabeneck, Jill Tinmouth
Background. Audit and feedback (A/F) reports are one of the few knowledge translation activities that can effect change in physician behavior. In this study, we pilot-tested an endoscopist A/F report to elicit opinions about the proposed report's usability, acceptability and usefulness, and implications for knowledge translation. Methods. Semi-structured qualitative interviews were conducted with eleven endoscopists in Ontario, Canada. We tested an A/F report template comprising 9 validated, accepted colonoscopy quality indicators populated with simulated data...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27660750/vegf-polymorphisms-related-to-higher-serum-levels-of-protein-identify-patients-with-hepatocellular-carcinoma
#15
Maria Eduarda Lopes Baitello, Graciele Domitila Tenani, Rafael Fernandes Ferreira, Victor Nogueira, Marcela Augusta de Souza Pinhel, Rita de Cássia Martins Alves da Silva, Renato Ferreira da Silva, Patrícia da Silva Fucuta, Moacir Fernandes de Godoy, Dorotéia Rossi Silva Souza
Hepatocellular carcinoma (HCC) is the most common primary neoplasia of the liver. Major risk factors for hepatocellular carcinoma include chronic liver diseases, carcinogenic agents, and genetic alterations as well as vascular endothelial growth factor (VEGF) involved in angiogenesis process. The aim of this study was to evaluate the association of VEGF-A (C936T and A1154G) with HCC and cirrhosis, in addition to serum levels of VEGF, clinical profile, lifestyle habits, and comorbidities. A total of 346 individuals were studied: 102 with HCC (G1), 117 with cirrhosis (G2), and 127 controls (G3)...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27656638/assessment-of-liver-stiffness-in-pediatric-fontan-patients-using-transient-elastography
#16
Becky Chen, Richard A Schreiber, Derek G Human, James E Potts, Orlee R Guttman
Background. Hepatic fibrosis is a potential complication following Fontan surgery and heralds long-term risk for cirrhosis. Transient elastography (TE) is a rapid, noninvasive method to assess liver fibrosis by measuring liver stiffness. Objectives. To compare liver stiffness and liver biochemistries in pediatric Fontan patients with age- and sex-matched controls and to determine patients' acceptance of TE. Methods. Patients were recruited from British Columbia Children's Hospital. Twenty-two Fontan patients (15 males) were identified...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27648440/repeat-endoscopic-ultrasound-guided-fine-needle-aspiration-in-patients-with-suspected-pancreatic-cancer-diagnostic-yield-and-associated-change-in-access-to-appropriate-care
#17
Robert A Mitchell, Dylan Stanger, Constantin Shuster, Jennifer Telford, Eric Lam, Robert Enns
Background. There is a high incidence of inconclusive cytopathology at initial EUS-FNA (endoscopic ultrasound-guided fine-needle aspiration) for suspected malignant pancreatic lesions. To obtain appropriate preoperative or palliative chemotherapy for pancreatic cancer, definitive cytopathology is often required. The utility of repeat EUS-FNA is not well established. Methods. A retrospective cohort study was conducted evaluating the yield of repeat EUS-FNA in determining a cytological diagnosis in patients who had undergone a prior EUS-FNA for diagnosis of suspected malignant pancreatic lesions with inconclusive cytopathology...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27648439/endoscopic-versus-percutaneous-biliary-drainage-in-palliation-of-advanced-malignant-hilar-obstruction-a-meta-analysis-and-systematic-review
#18
REVIEW
Harsha Moole, Sirish Dharmapuri, Abhiram Duvvuri, Sowmya Dharmapuri, Raghuveer Boddireddy, Vishnu Moole, Prathyusha Yedama, Naveen Bondalapati, Achuta Uppu, Charan Yerasi
Background. Palliation in advanced unresectable hilar malignancies can be achieved by endoscopic (EBD) or percutaneous transhepatic biliary drainage (PTBD). It is unclear if one approach is superior to the other in this group of patients. Aims. Compare clinical outcomes of EBD versus PTBD. Methods. (i) Study Selection Criterion. Studies using PTBD and EBD for palliation of advanced unresectable hilar malignancies. (ii) Data Collection and Extraction. Articles were searched in Medline, PubMed, and Ovid journals...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27648438/esophageal-intramural-pseudodiverticulosis-and-concomitant-eosinophilic-esophagitis-a-case-series
#19
Michael A Scaffidi, Ankit Garg, Brandon Ro, Christopher Wang, Tony T C Yang, Ian S Plener, Andrea Grin, Errol Colak, Samir C Grover
Background. Esophageal intramural pseudodiverticulosis (EIPD) is an idiopathic benign chronic disease characterized by flask-like outpouchings of the esophageal wall. It is unknown whether there is a genuine association between EIPD and eosinophilic esophagitis (EoE). Aims. To investigate a possible relationship between EIPD and EoE. Methods. Patients with radiographic or endoscopic evidence of pseudodiverticulosis were identified from the database at a single academic center. Cases were analyzed in three areas: clinical information, endoscopic findings, and course...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27630977/two-person-technique-of-peroral-endoscopic-myotomy-for-achalasia-with-an-advanced-endoscopist-and-a-thoracic-surgeon-initial-experience
#20
Madhusudhan R Sanaka, Ramprasad Jegadeesan, Prashanthi N Thota, Udayakumar Navaneethan, Rocio Lopez, Sudish C Murthy, Siva Raja
Background and Aims. We initiated peroral endoscopic myotomy (POEM) utilizing a two-person technique with combination of an advanced endoscopist and a thoracic surgeon with complementary skills. Our aim was to determine the feasibility and outcomes in initial 20 patients. Methods. In this observational study, main outcomes measured were therapeutic success in relieving symptoms (Eckardt score < 3), decrease in lower esophageal sphincter (LES) pressures, improvement in emptying on timed barium esophagogram (TBE), and complications...
2016: Canadian Journal of Gastroenterology & Hepatology
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