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Canadian Journal of Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/29333428/the-effect-of-prucalopride-on-small-bowel-transit-time-in-hospitalized-patients-undergoing-capsule-endoscopy
#1
Majid Alsahafi, Paula Cramer, Nazira Chatur, Fergal Donnellan
Background: The inpatient status is a well-known risk factor for incomplete video capsule endoscopy (VCE) examinations due to prolonged transit time. We aimed to evaluate the effect of prucalopride on small bowel transit time for hospitalized patients undergoing VCE. Methods: We included all hospitalized patients who underwent VCE at a tertiary academic center from October 2011 through September 2016. A single 2 mg dose of prucalopride was given exclusively for all patients who underwent VCE between March 2014 and December 2015...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29259967/prognostic-impact-of-cirrhosis-in-patients-with-intrahepatic-cholangiocarcinoma-following-hepatic-resection
#2
Seogsong Jeong, Lei Gao, Ying Tong, Lei Xia, Ning Xu, Meng Sha, Jianjun Zhang, Xiaoni Kong, Jinyang Gu, Qiang Xia
Background: Prognostic impact of cirrhosis in patients with intrahepatic cholangiocarcinoma (ICC) upon hepatic resection remains unclear due to lack of studies in the literature. Methods: A total of 106 resected patients with ICC were reviewed, including 25 patients (23.6%) with cirrhosis and 81 noncirrhotic patients (76.4%). Subgroups of cirrhotic patients with and without hepatitis B virus (HBV) infection were studied. Results: The impact of cirrhosis on the overall survival (OS) (hazard ratio [HR], 0...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29238704/laparoscopy-assisted-versus-open-hepatectomy-for-live-liver-donor-systematic-review-and-meta-analysis
#3
REVIEW
Bin Zhang, Yu Pan, Ke Chen, Hendi Maher, Ming-Yu Chen, He-Pan Zhu, Yi-Bin Zhu, Yi Dai, Jiang Chen, Xiu-Jun Cai
Objective: To assess the feasibility, safety, and potential benefits of laparoscopy-assisted living donor hepatectomy (LADH) in comparison with open living donor hepatectomy (ODH) for liver transplantation. Background: LADH is becoming increasingly common for living donor liver transplant around the world. We aim to determine the efficacy of LADH and compare it with ODH. Methods: A systematic search on PubMed, Embase, Cochrane Library, and Web of Science was conducted in May 2017...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29226116/alcohol-consumption-in-diabetic-patients-with-nonalcoholic-fatty-liver-disease
#4
Preya J Patel, David Smith, Jason P Connor, Leigh U Horsfall, Kelly L Hayward, Fabrina Hossain, Suzanne Williams, Tracey Johnson, Katherine A Stuart, Nigel N Brown, Nivene Saad, Andrew D Clouston, Katharine M Irvine, Anthony W Russell, Patricia C Valery, Elizabeth E Powell
Aim: To examine the association between lifetime alcohol consumption and significant liver disease in type 2 diabetic patients with NAFLD. Methods: A cross-sectional study assessing 151 patients with NAFLD at risk of clinically significant liver disease. NAFLD fibrosis severity was classified by transient elastography; liver stiffness measurements ≥8.2 kPa defined significant fibrosis. Lifetime drinking history classified patients into nondrinkers, light drinkers (always ≤20 g/day), and moderate drinkers (any period with intake >20 g/day)...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29226115/body-composition-in-crohn-s-disease-and-ulcerative-colitis-correlation-with-disease-severity-and-duration
#5
Dawesh P Yadav, Saurabh Kedia, Kumble Seetharama Madhusudhan, Sawan Bopanna, Sandeep Goyal, Saransh Jain, Naval K Vikram, Raju Sharma, Govind K Makharia, Vineet Ahuja
Background: Results on body composition in Crohn's disease (CD) and ulcerative colitis (UC) have been heterogeneous and are lacking from Asia. Present study assessed body composition in CD/UC and correlated it with disease severity/duration. Methods: Patients of CD/UC following between Dec 2014 and Dec 2015 who consented for bioimpedance analysis for body fat measurement were included. Lean mass and fat-free mass index (FFMI) were calculated with standard formulae...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29181373/prevalence-of-anxiety-and-depression-in-patients-with-inflammatory-bowel-disease
#6
Glynis Byrne, Greg Rosenfeld, Yvette Leung, Hong Qian, Julia Raudzus, Carlos Nunez, Brian Bressler
Background: Inflammatory bowel disease (IBD) patients are not routinely screened for depression and anxiety despite knowledge of an increased prevalence in people with chronic disease and negative effects on quality of life. Methods: Prevalence of anxiety and depression was assessed in IBD outpatients through retrospective chart review. The presence of anxiety and/or depression was determined using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 self-report questionnaires or by diagnosis through psychiatric interview...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29147647/serum-albumin-is-independently-associated-with-persistent-organ-failure-in-acute-pancreatitis
#7
Wandong Hong, Suhan Lin, Maddalena Zippi, Wujun Geng, Simon Stock, Zarrin Basharat, Bicheng Cheng, Jingye Pan, Mengtao Zhou
Background and Aims: To investigate the association between serum albumin levels within 24 hrs of patient admission and the development of persistent organ failure in acute pancreatitis. Methods: A total of 700 patients with acute pancreatitis were enrolled. Multivariate logistic regression and subgroup analysis determined whether decreased albumin was independently associated with persistent organ failure and mortality. The diagnostic performance of serum albumin was evaluated by the area under Receiver Operating Characteristic (ROC) curves...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29098144/exploration-of-superior-modality-safety-and-efficacy-of-hypofractioned-image-guided-intensity-modulated-radiation-therapy-in-patients-with-unresectable-but-confined-intrahepatic-hepatocellular-carcinoma
#8
Tao Jiang, Zhao-Chong Zeng, Ping Yang, Yong Hu
Purpose: To evaluate the efficacy and safety of hypofractioned image-guided intensity modulated radiation therapy (IG-IMRT) for unresectable but confined intrahepatic hepatocellular carcinoma in comparison with conventional 3-dimensional conformal radiotherapy (3D-CRT). Methods: Ninety patients with unresectable but confined intrahepatic hepatocellular carcinoma without distant metastasis and tumor thrombosis received external beam radiation therapy. Of these patients, 45 received IG-IMRT and 45 received 3D-CRT...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29090208/normal-uptake-of-11-c-acetate-in-pancreas-liver-spleen-and-suprarenal-gland-in-pet
#9
Bogdan Malkowski, Pawel Wareluk, Tomasz Gorycki, Katarzyna Skrobisz, Michal Studniarek
PURPOSE: (11)C-Acetate is radiotracer being considered an alternative to (18)F-fluorodeoxyglucose. Evaluation of (11)C-acetate biodistribution in human parenchymal organs is described. METHODS AND MATERIALS: 60 consecutive patients referred to (11)C-acetate PET CT suspected of renal or prostate cancer relapse with negative results (no recurrent tumor) were included in the study. Acquisition from the base of skull to upper thigh was made 20 min after i.v. injection of 720 MBq of (11)C-acetate...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29082224/repeat-colonoscopy-within-6-months-after-initial-outpatient-colonoscopy-in-ontario-a-population-based-cross-sectional-study
#10
Lawrence Paszat, Rinku Sutradhar, Nancy N Baxter, Jill Tinmouth, Linda Rabeneck
BACKGROUND: The goal of this study is to examine utilization of early repeat colonoscopy ≤ 6 months after an index procedure. METHODS: We identified persons having repeat colonoscopy ≤ 6 months following outpatient colonoscopy without prior colonoscopy ≤ 5 years or prior diagnosis of colorectal cancer (CRC). We modeled repeat colonoscopy using a generalized estimating equation with an exchangeable correlation structure to account for clustering of patients by endoscopist...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28951864/establishing-a-porcine-model-of-small-for-size-syndrome-following-liver-resection
#11
Mohammad Golriz, Maryam Ashrafi, Elias Khajeh, Ali Majlesara, Christa Flechtenmacher, Arianeb Mehrabi
BACKGROUND: Small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection. AIM: The aim of this study was to establish a porcine model of SFSS. METHODS: Twenty-four Landrace pigs underwent liver resection with a remnant liver volume of 50% (group A, n = 8), 25% (group B, n = 8), and 15% (group C, n = 8). After resection, the animals were followed up for 8 days and clinical, laboratory, and histopathological outcomes were evaluated...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28913325/bone-loss-prevention-of-bisphosphonates-in-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#12
REVIEW
Yan Hu, Xiaoting Chen, Xiaojing Chen, Shuang Zhang, Tianyan Jiang, Jing Chang, Yanhong Gao
OBJECTIVE: The purpose of this study was to evaluate the effect of bisphosphonates in improving bone mineral density (BMD) and decreasing the occurrence rate of fractures and adverse events in patients with inflammatory bowel disease (IBD). METHODS: Randomized controlled trials (RCTs) which use bisphosphonates in IBD patients were identified in PubMed, MEDLINE database, EMBASE database, Web of Knowledge, and the Cochrane Databases between 1990 and June 2016. People received bisphosphonate or placebos with a follow-up of at least one year were also considered...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28815170/the-geography-of-primary-hepatic-neoplasms-treatments-in-canada-changes-in-latitudes-and-changes-in-attitudes
#13
Matthew Cwinn, Gordon Walsh, Sheikh Hasibur Rahman, Michele Molinari
BACKGROUND: Studies on treatment modalities for primary hepatic neoplasms (PHN) in Canada are lacking. Our primary aim was to analyze the age-standardized incidence of hepatic resection, ablation, transplantation, and embolization for PHN between 2002 and 2013. Secondary aim was to evaluate temporal trends for these treatment modalities. STUDY DESIGN: National Canadian Cancer Registries were accessed for relevant epidemiological data. Age-standardized incidence of treatment ratios (SIRs) was calculated and comparisons were performed for Atlantic Canada, Ontario, the Prairies, and British Columbia...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28812008/evaluation-of-adrenal-function-in-nonhospitalized-patients-with-cirrhosis
#14
Maryam Moini, Mitra Yazdani Sarvestani, Mesbah Shams, Masood Nomovi
BACKGROUND: Patients with cirrhosis and advancing hepatic insufficiency may show various degrees of other organ malfunction, including brain, kidney, and lung. Several studies have also shown a high prevalence of adrenal insufficiency in cirrhotic patients that may cause hemodynamic instability. MATERIALS AND METHODS: In this study we prospectively evaluated adrenal function in a population of nonhospitalized cirrhotic patients. Categorization of liver disease severity was done according to model for end-stage liver disease (MELD) score...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28808653/acyl-coa-synthetase-5-promotes-the-growth-and-invasion-of-colorectal-cancer-cells
#15
Shihua Ding, Shaohui Tang, Min Wang, Donghai Wu, Haijian Guo
BACKGROUND AND AIMS: Acyl-CoA synthetase 5 (ACS5) has been reported to be associated with the development of various cancers, but the role of it in colorectal cancer (CRC) is not well understood. The present study aimed to explore the potential role of ACS5 in the development and progression of CRC. METHODS: ACS5 expression in CRC tissues and CRC cell lines was examined, and its clinical significance was analyzed. The role of ACS5 in cell proliferation, apoptosis, and invasion was examined in vitro...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28804705/possible-involvement-of-liver-resident-macrophages-kupffer-cells-in-the-pathogenesis-of-both-intrahepatic-and-extrahepatic-inflammation
#16
Yuki Kakinuma, Takuya Kimura, Yoshifumi Watanabe
Liver resident macrophages designated Kupffer cells (KCs) form the largest subpopulation of tissue macrophages. KCs are involved in the pathogenesis of liver inflammation. However, the role of KCs in the systemic inflammation is still elusive. In this study, we examined whether KCs are involved in not only intrahepatic inflammation but also extrahepatic systemic inflammation. Administration of clodronate liposomes resulted in the KC deletion and in the suppression of liver injury in T cell-mediated hepatitis by ConA as a local acute inflammation model, while the treatment did not influence dextran sulfate sodium- (DSS-) induced colitis featured by weight loss, intestinal shrink, and pathological observation as an ectopic local acute inflammation model...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28785552/corrigendum-to-assessment-of-school-readiness-in-chronic-cholestatic-liver-disease-a-pilot-study-examining-children-with-and-without-liver-transplantation
#17
Anna Gold, Alaine Rogers, Elizabeth Cruchley, Stephanie Rankin, Arpita Parmar, Binita M Kamath, Yaron Avitzur, Vicky Lee Ng
[This corrects the article DOI: 10.1155/2017/9873945.].
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28785551/the-prevalence-of-hjortsjo-crook-sign-of-right-posterior-sectional-bile-duct-and-bile-duct-anatomy-in-ercp
#18
Hanan M Alghamdi, Afnan F Almuhanna, Bander F Aldhafery, Raed M AlSulaiman, Ahmed Almarhabi, Abdulaziz AlQurain
AIM: The frequency of the Right Posterior Sectional Bile Duct (RPSBD) hump sign in cholangiogram when it crosses over the right portal vein known as Hjortsjo Crook Sign and the bile duct anatomy are studied. Knowledge of the implication of positive sign can facilitate safe resection for both bile duct and portal vein. METHODS: Prospectively, we included 237 patients with indicated ERCP during a period from March 2010 to January 2015. RESULTS: The mean age (±SD) and male to female ratio were 38...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28781966/obesity-increases-prevalence-of-colonic-adenomas-at-screening-colonoscopy-a-canadian-community-based-study
#19
Theodore F Shapero, Grant I Chen, Tim Devlin, Alison Gibbs, Iain C Murray, Stanley Tran, Corey Weigensberg
BACKGROUND AND AIMS: Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. METHODS: We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calculated at enrolment. Hyperlipidemia (HL), hypertension (HT), and diabetes mellitus (DM) were identified. Details of colonoscopy, polypectomy, and histology were recorded...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28770186/corrigendum-to-prebiotics-a-novel-approach-to-treat-hepatocellular-carcinoma
#20
Naz Fatima, Tasleem Akhtar, Nadeem Sheikh
[This corrects the article DOI: 10.1155/2017/6238106.].
2017: Canadian Journal of Gastroenterology & Hepatology
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