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Journal of Therapeutic Ultrasound

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https://www.readbyqxmd.com/read/27882240/t2-based-temperature-monitoring-in-bone-marrow-for-mr-guided-focused-ultrasound
#1
Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug, Viola Rieke
BACKGROUND: Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the temperature of the bone. The goal of this study was to determine if T2-based thermometry could be used to monitor the temperature change in bone marrow during focused ultrasound ablation of bone lesions. METHODS: We investigated the dependence of T2 on temperature in ex vivo bovine yellow bone marrow at 3T and studied the influence of acquisition parameters on the T2 measurements...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27822376/the-safety-and-effectiveness-of-volumetric-magnetic-resonance-guided-high-intensity-focused-ultrasound-treatment-of-symptomatic-uterine-fibroids-early-clinical-experience-in-china
#2
Rui Chen, Bilgin Keserci, Hui Bi, Xiaobing Han, Xiaoying Wang, Wenpei Bai, Yueling Wang, Xuedong Yang, Jian Yang, Juan Wei, Minna Seppälä, Antti Viitala, Qinping Liao
BACKGROUND: Uterine fibroids are the most common benign tumor in women, and surgical intervention is still the main fibroid treatment. Patient demands have encouraged development of less-invasive methods such as high-intensity focused ultrasound (HIFU). This study aimed to evaluate the safety and effectiveness of magnetic resonance-guided high-intensity focused ultrasound therapy using a volumetric ablation technique in the treatment of symptomatic uterine fibroids in China. METHODS: One hundred and seven patients were enrolled and treated with magnetic resonance-guided high-intensity focused ultrasound in this study...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27785362/low-intensity-pulsed-ultrasound-stimulation-in-different-regions-in-the-viability-of-myocutaneous-flaps
#3
Fernanda Luiza de Almeida Albuquerque, Lais Mara Siqueira das Neves, Elaine Caldeira de Oliveira Guirro
BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) has presented good results in the healing of chronic wounds. The objective of this study was to compare the effect of LIPUS on the viability of transverse rectus abdominal muscle (TRAM) flap in different regions (central and epigastric) in rats. METHODS: Twenty-one Wistar male rats were homogeneously distributed into three groups as follows: group 1 (control), animals submitted to surgery only; group 2, animals submitted to surgery and application of LIPUS at the center of the flap; and group 3, animals submitted to surgery and application of LIPUS at the flap area corresponding to the right inferior epigastric artery pedicle...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27777767/erratum-to-open-source-small-animal-magnetic-resonance-guided-focused-ultrasound-system
#4
Megan E Poorman, Vandiver L Chaplin, Ken Wilkens, Mary D Dockery, Todd D Giorgio, William A Grissom, Charles F Caskey
[This corrects the article DOI: 10.1186/s40349-016-0066-7.].
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27729978/the-influence-of-low-intensity-physiotherapeutic-ultrasound-on-the-initial-stage-of-bone-healing-in-rats-an-experimental-and-simulation-study
#5
Aldo José Fontes-Pereira, Marcio Amorim, Fernanda Catelani, Daniel Patterson Matusin, Paulo Rosa, Douglas Magno Guimarães, Marco Antônio von Krüger, Wagner Coelho de Albuquerque Pereira
BACKGROUND: Low-intensity physiotherapeutic ultrasound has been used in physical therapy clinics; however, there remain some scientific issues regarding the bone-healing process. The objective of this study was to investigate the influence of low-intensity physiotherapeutic ultrasound on the initial stage of bone healing in rats. METHODS: Twenty-two male adult rats were assessed quantitatively and qualitatively using radiographic, biochemical, and histological analyses...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27688881/mr-thermometry-for-focused-ultrasound-monitoring-utilizing-model-predictive-filtering-and-ultrasound-beam-modeling
#6
Henrik Odéen, Scott Almquist, Joshua de Bever, Douglas A Christensen, Dennis L Parker
BACKGROUND: A major challenge in using magnetic resonance temperature imaging (MRTI) to monitor focused ultrasound (FUS) applications is achieving high spatio-temporal resolution over a large field of view (FOV). This is important to accurately monitor all ultrasound (US) power depositions. Magnetic resonance (MR) subsampling in conjunction with thermal model-based reconstruction of the MRTI utilizing Pennes bioheat transfer equation (PBTE) is one promising approach. The thermal properties used in the thermal model are often estimated from a pre-treatment, low-power sonication...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27597889/open-source-small-animal-magnetic-resonance-guided-focused-ultrasound-system
#7
Megan E Poorman, Vandiver L Chaplin, Ken Wilkens, Mary D Dockery, Todd D Giorgio, William A Grissom, Charles F Caskey
BACKGROUND: MR-guided focused ultrasound or high-intensity focused ultrasound (MRgFUS/MRgHIFU) is a non-invasive therapeutic modality with many potential applications in areas such as cancer therapy, drug delivery, and blood-brain barrier opening. However, the large financial costs involved in developing preclinical MRgFUS systems represent a barrier to research groups interested in developing new techniques and applications. We aim to mitigate these challenges by detailing a validated, open-source preclinical MRgFUS system capable of delivering thermal and mechanical FUS in a quantifiable and repeatable manner under real-time MRI guidance...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27536356/influence-of-therapeutic-ultrasound-on-the-biomechanical-characteristics-of-the-skin
#8
Lígia Brancalion Catapani, Adriana da Costa Gonçalves, Nathalia Morano Candeloro, Lídia Aparecida Rossi, Elaine Caldeira de Oliveira Guirro
BACKGROUND: Skin function is dependent on its biomechanical characteristics, resistance, malleability, and elasticity. Therapeutic ultrasound may increase cutaneous malleability thus and optimize the rehabilitation process on specific diseases. The aim of this study is to evaluate possible alterations of biomechanical characteristics of the normal skin after therapeutic ultrasound application. METHODS: Thirty-one volunteers took part of the study, and the average age was 31...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27525101/volumetric-mr-guided-high-intensity-focused-ultrasound-ablation-to-treat-uterine-fibroids-through-the-abdominal-scars-using-scar-patch-a-case-report
#9
Ying Zhu, Bilgin Keserci, Antti Viitala, Juan Wei, Xuedong Yang, Xiaoying Wang
BACKGROUND: Abdominal scars pose a challenge in magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) therapies, limiting patient selection and increasing the risk of skin burns. Especially, scars arising from longitudinal incisions are problematic as they usually lie medially at the lower abdomen where the ultrasound beam has to go through. Volumetric sonication has been shown to efficiently enlarge the ablated volume per sonication, but they nevertheless require more thermal energy to be deposited per sonication which increases the temperature in the near-field area located between the transducer and the target region...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27478615/procedural-sedation-and-analgesia-for-respiratory-gated-mr-hifu-in-the-liver-a-feasibility-study
#10
Johanna M M van Breugel, Joost W Wijlemans, Hermanus H B Vaessen, Martijn de Greef, Chrit T W Moonen, Maurice A A J van den Bosch, Mario G Ries
BACKGROUND: Previous studies demonstrated both pre-clinically and clinically the feasibility of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablations in the liver. To overcome the associated problem of respiratory motion of the ablation area, general anesthesia (GA) and mechanical ventilation was used in conjunction with either respiratory-gated energy delivery or energy delivery during induced apnea. However, clinical procedures requiring GA are generally associated with increased mortality, morbidity, and complication rate compared to procedural sedation and analgesia (PSA)...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27429753/utilization-of-diagnostic-ultrasound-and-intravenous-lipid-encapsulated-perfluorocarbons-in-non-invasive-targeted-cardiovascular-therapeutics
#11
REVIEW
Thomas R Porter, Songita A Choudhury, Feng Xie
Diagnostic ultrasound (DUS) pressures have the ability to induce inertial cavitation (IC) of systemically administered microbubbles; this bioeffect has many diagnostic and therapeutic implications in cardiovascular care. Diagnostically, commercially available lipid-encapsulated perfluorocarbons (LEP) can be utilized to improve endocardial and vascular border delineation as well as assess myocardial perfusion. Therapeutically, the liquid jets induced by IC can alter endothelial function and dissolve thrombi within the immediate vicinity of the cavitating microbubbles...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27213044/acoustic-neuromodulation-from-a-basic-science-prospective
#12
REVIEW
Elisabetta Sassaroli, Natalia Vykhodtseva
We present here biophysical models to gain deeper insights into how an acoustic stimulus might influence or modulate neuronal activity. There is clear evidence that neural activity is not only associated with electrical and chemical changes but that an electro-mechanical coupling is also involved. Currently, there is no theory that unifies the electrical, chemical, and mechanical aspects of neuronal activity. Here, we discuss biophysical models and hypotheses that can explain some of the mechanical aspects associated with neuronal activity: the soliton model, the neuronal intramembrane cavitation excitation model, and the flexoelectricity hypothesis...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27213043/establishing-a-clinical-service-for-the-treatment-of-osteoid-osteoma-using-magnetic-resonance-guided-focused-ultrasound-overview-and-guidelines
#13
REVIEW
Michael J Temple, Adam C Waspe, Joao G Amaral, Alessandro Napoli, Suzanne LeBlang, Pejman Ghanouni, Matthew D Bucknor, Fiona Campbell, James M Drake
Recent studies have demonstrated the effectiveness of magnetic resonance-guided focused ultrasound (MRgFUS) in the treatment of osteoid osteoma (OO), a painful, benign bone tumor. As MRgFUS is a noninvasive and radiation-free treatment, it stands to replace the current standard of care, percutaneous radiofrequency, or laser thermal ablation. Within an institution, creation of a clinical OO MRgFUS treatment program would not only provide cutting edge medical treatment at the current time but would also establish the foundation for an MRgFUS clinical service to introduce treatments currently under development into clinical practice in the future...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27081486/detection-of-tissue-coagulation-by-decorrelation-of-ultrasonic-echo-signals-in-cavitation-enhanced-high-intensity-focused-ultrasound-treatment
#14
Shin Yoshizawa, Keiko Matsuura, Ryo Takagi, Mariko Yamamoto, Shin-Ichiro Umemura
BACKGROUND: A noninvasive technique to monitor thermal lesion formation is necessary to ensure the accuracy and safety of high-intensity focused ultrasound (HIFU) treatment. The purpose of this study is to ultrasonically detect the tissue change due to thermal coagulation in the HIFU treatment enhanced by cavitation microbubbles. METHODS: An ultrasound imaging probe transmitted plane waves at a center frequency of 4.5 MHz. Ultrasonic radio-frequency (RF) echo signals during HIFU exposure at a frequency of 1...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27054038/evaluation-of-mri-protocols-for-the-assessment-of-lumbar-facet-joints-after-mr-guided-focused-ultrasound-treatment
#15
Roland Krug, Loi Do, Viola Rieke, Mark W Wilson, Maythem Saeed
BACKGROUND: MR-guided focused ultrasound (MRgFUS) might be a very safe and effective minimally invasive technique to treat facet joint pain caused by arthritis and other degenerative changes. However, there are still safety concerns for this treatment and challenges regarding MR imaging and temperature mapping due to susceptibility effects between the bone and soft tissue near the joint, which has resulted in poor MR image quality. The goal of this research was to evaluate multiple magnetic resonance imaging (MRI) pulse sequences for characterizing ablated lumbar facet joint lesions created by high-intensity focused ultrasound (FUS) and compare the findings to histological tissue assessment...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27051520/assessing-heating-distribution-by-therapeutic-ultrasound-on-bone-phantoms-and-in-vitro-human-samples-using-infrared-thermography
#16
Gabriella Sellani, Dalila Fernandes, Abigail Nahari, Melissa Fabrício de Oliveira, Christiana Valois, Wagner C A Pereira, Christiano B Machado
BACKGROUND: Bioheat models have been proposed to predict heat distribution in multilayered biological tissues after therapeutic ultrasound (TUS) stimulation. However, evidence on its therapeutic benefit is still controversial for many clinical conditions. The aim of this study was to evaluate and to compare the TUS heating distribution on commercially available bone phantoms and in vitro femur and tibia human samples, at 1 MHz and several ultrasonic pulse regimens, by means of a thermographic image processing technique...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27042308/magnetic-resonance-guided-high-intensity-focused-ultrasound-combined-with-radiotherapy-for-palliation-of-head-and-neck-cancer-a-pilot-study
#17
Justin Lee, Georges Farha, Ian Poon, Irene Karam, Kevin Higgins, Samuel Pichardo, Kullervo Hynynen, Danny Enepekides
BACKGROUND: Radiotherapy is a critical component of the multidisciplinary management of cancers of the head and neck. It may comprise the primary curative treatment modality or is used in an adjuvant setting to improve local control and survival by preventing seeding and reseeding of distant metastases from persistent reservoirs of locoregional disease. Although considerable advances have been made recently in the fields of radiotherapy, systemic treatment and surgery for head and neck tumours, locoregional recurrence rates remain high and treatment side effects may have severe impact on patients' quality of life...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27034778/simulation-of-high-intensity-focused-ultrasound-lesions-in-presence-of-boiling
#18
Anthony Grisey, Sylvain Yon, Véronique Letort, Pauline Lafitte
BACKGROUND: The lesions induced by high-intensity focused ultrasound (HIFU) thermal ablations are particularly difficult to simulate due to the complexity of the involved phenomena. In particular, boiling has a strong influence on the lesion shape. Thus, it must be accounted for if it happens during the pulses to be modeled. However, no acoustic model enables the simulation of the resulting wave scattering. Therefore, we propose an equivalent model for the heat deposition pattern in the presence of boiling...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27030807/in-vitro-cell-treatment-with-focused-shockwaves-influence-of-the-experimental-setup-on-the-sound-field-and-biological-reaction
#19
Kristin Dietz-Laursonn, Rainer Beckmann, Siegfried Ginter, Klaus Radermacher, Matías de la Fuente
BACKGROUND: To improve understanding of shockwave therapy mechanisms, in vitro experiments are conducted and the correlation between cell reaction and shockwave parameters like the maximum pressure or energy density is studied. If the shockwave is not measured in the experimental setup used, it is usually assumed that the device's shockwave parameters (=manufacturer's free field measurements) are valid. But this applies only for in vitro setups which do not modify the shockwave, e.g., by reflection or refraction...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/26981241/dce-mri-and-ivim-mri-of-rabbit-vx2-tumors-treated-with-mr-hifu-induced-mild-hyperthermia
#20
Mie K Lam, Chris Oerlemans, Martijn Froeling, Roel Deckers, Angelique D Barten-Van Rijbroek, Max A Viergever, Chrit T W Moonen, Clemens Bos, Lambertus W Bartels
BACKGROUND: The purpose of this study is to investigate whether changes could be detected in dynamic contrast-enhanced (DCE) and intra-voxel incoherent motion (IVIM) MR parameters upon MR-guided high-intensity focused ultrasound (MR-HIFU)-induced hyperthermia in a rabbit Vx2 tumor model. METHODS: Five Vx2 tumor-bearing New Zealand white rabbits were treated with hyperthermia using a clinical MR-HIFU system. Data were acquired before and after hyperthermia. For the DCE analysis, the extended Tofts model was used...
2016: Journal of Therapeutic Ultrasound
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