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Journal of Therapeutic Ultrasound

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https://www.readbyqxmd.com/read/29214024/calcium-dependent-ultrasound-stimulation-of-secretory-events-from-pancreatic-beta-cells
#1
Ivan Suarez Castellanos, Tania Singh, Bogdan Balteanu, Diti Chatterjee Bhowmick, Aleksandar Jeremic, Vesna Zderic
Background: Our previous studies have indicated that ultrasound can stimulate the release of insulin from pancreatic beta cells, providing a potential novel treatment for type 2 diabetes. The purpose of this study was to explore the temporal dynamics and Ca2+-dependency of ultrasound-stimulated secretory events from dopamine-loaded pancreatic beta cells in an in vitro setup. Methods: Carbon fiber amperometry was used to detect secretion from INS-1832/13 beta cells in real time...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29152303/multiple-ultrasound-cavitation-enabled-treatments-for-myocardial-reduction
#2
Douglas L Miller, Xiaofang Lu, Chunyan Dou, Yiying I Zhu, Mario L Fabiilli, Gabe E Owens, Oliver D Kripfgans
Background: Ultrasound myocardial cavitation enabled treatment (MCET) is an image-guided method for tissue reduction. In this study, a strategy of fractionated (multiple) treatments was tested for efficacy. Methods: Dahl SS rats were anesthetized and prepared for treatment with a focused ultrasound transducer in a warm water bath. Aiming at the anterior left ventricular wall was facilitated by imaging with a 10 MHz phased array (10S, GE Vivid 7, GE Vingmed Ultrasound, Horten, Norway)...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29118984/clinical-trial-protocol-for-tardox-a-phase-i-study-to-investigate-the-feasibility-of-targeted-release-of-lyso-thermosensitive-liposomal-doxorubicin-thermodox%C3%A2-using-focused-ultrasound-in-patients-with-liver-tumours
#3
Paul C Lyon, Lucy F Griffiths, Jenni Lee, Daniel Chung, Robert Carlisle, Feng Wu, Mark R Middleton, Fergus V Gleeson, Constantin C Coussios
Background: TARDOX is a Phase I single center study of ultrasound triggered targeted drug delivery in adult oncology patients with incurable liver tumours. This proof of concept study is designed to demonstrate the safety and feasibility of targeted drug release and enhanced delivery of doxorubicin from thermally sensitive liposomes (ThermoDox®) triggered by mild hyperthermia induced by focused ultrasound in liver tumours. A key feature of the study is the direct quantification of the doxorubicin concentration before and after ultrasound exposure from tumour biopsies, using high performance liquid chromatography (HPLC)...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29043083/a-framework-for-continuous-target-tracking-during-mr-guided-high-intensity-focused-ultrasound-thermal-ablations-in-the-abdomen
#4
Cornel Zachiu, Baudouin Denis de Senneville, Ivan D Dmitriev, Chrit T W Moonen, Mario Ries
BACKGROUND: During lengthy magnetic resonance-guided high intensity focused ultrasound (MRg-HIFU) thermal ablations in abdominal organs, the therapeutic work-flow is frequently hampered by various types of physiological motion occurring at different time-scales. If left un-addressed this can lead to an incomplete therapy and/or to tissue damage of organs-at-risk. While previous studies focus on correction schemes for displacements occurring at a particular time-scale within the work-flow of an MRg-HIFU therapy, in the current work we propose a motion correction strategy encompassing the entire work-flow...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29034095/current-and-emerging-brain-applications-of-mr-guided-focused-ultrasound
#5
REVIEW
Ying Meng, Suganth Suppiah, Karim Mithani, Benjamin Solomon, Michael L Schwartz, Nir Lipsman
MRI guided focused ultrasound is an emerging technique that uses acoustic energy to noninvasively treat intracranial disorders. At high frequencies, it can be used to raise tissue temperatures and ablate discrete brain targets with sub-millimeter accuracy. This application is currently under investigation for a broad range of clinical applications, including brain tumors, movement disorders, and psychiatric conditions. At low frequencies MRI guided focused ultrasound can be used to modulate neuronal activity and in conjunction with injected microbubbles, can open the blood-brain barrier to enhance the delivery of therapeutic compounds...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28944056/magnetic-resonance-guided-high-intensity-focused-ultrasound-in-the-presence-of-biopsy-markers
#6
Charles Mougenot, Chrit Moonen
BACKGROUND: Magnetic Resonance guided High Intensity Focused ultrasound (MR-HIFU) offers precise non-invasive thermotherapy for clinical applications such as the treatment of breast lesions. However, patients with a biopsy marker are usually not eligible for MR-HIFU treatment. This study investigates the interaction of some MR-compatible markers with MR-HIFU thermotherapy. METHODS: The MR-HIFU compatibility of 14 markers (6 Gold Anchor and 4 Visicoil markers in gold, 1 Visicoil marker in brass, 3 BiomarC markers in carbon coated) were tested using the Sonalleve breast MR-HIFU platform at 1...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28924476/clinical-validation-of-real-time-tissue-change-monitoring-during-prostate-tissue-ablation-with-high-intensity-focused-ultrasound
#7
Narendra T Sanghvi, Wo-Hsing Chen, Roy Carlson, Clint Weis, Ralf Seip, Toyoaki Uchida, Michael Marberger
BACKGROUND: The purpose of these clinical studies was to validate a Tissue Change Monitoring (TCM) algorithm in vivo. TCM is a quantitative tool for the real-time assessment of HIFU dose. TCM provides quantitative analysis of the backscatter pulse echo signals (pre and immediately post HIFU) for each individual ablative site, using ultrasonic tissue characterization as a surrogate for monitoring tissue temperature. Real-time analysis generates an energy difference parameter (ΔE in dB) that is proportional to tissue temperature...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28824811/volumetric-magnetic-resonance-guided-high-intensity-focused-ultrasound-ablation-of-uterine-fibroids-through-abdominal-scars-the-impact-of-a-scar-patch-on-therapeutic-efficacy-and-adverse-effects
#8
Bilgin Keserci, Nguyen Minh Duc
BACKGROUND: To retrospectively compare the treatment success, therapeutic efficacy, and adverse effects of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) treatment for uterine fibroid patients with and without abdominal scars. METHODS: Seventy-six women who underwent treatment were divided into group 1 (patients with abdominal scars, which were covered with scar patches that prevents ultrasound energy from reaching the scar tissue immediately behind the patch) and group 2 (patients without abdominal scars)...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28794877/effects-of-hifu-induced-cavitation-on-flooded-lung-parenchyma
#9
Frank Wolfram, Georg Dietrich, Carsten Boltze, Klaus Vitold Jenderka, Thomas Günther Lesser
BACKGROUND: High intensity focused ultrasound (HIFU) has gained clinical interest as a non-invasive local tumour therapy in many organs. In addition, it has been shown that lung cancer can be targeted by HIFU using One-Lung Flooding (OLF). OLF generates a gas free saline-lung compound in one lung wing and therefore acoustic access to central lung tumours. It can be assumed that lung parenchyma is exposed to ultrasound intensities in the pre-focal path and in cases of misguiding. If so, cavitation might be induced in the saline fraction of flooded lung and cause tissue damage...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28781881/early-health-technology-assessment-of-magnetic-resonance-guided-high-intensity-focused-ultrasound-ablation-for-the-treatment-of-early-stage-breast-cancer
#10
Floortje M Knuttel, Sèvrin E M Huijsse, Talitha L Feenstra, Chrit T W Moonen, Maurice A A J van den Bosch, Erik Buskens, Marcel J W Greuter, Geertruida H de Bock
BACKGROUND: Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) ablation is in development for minimally invasive treatment of breast cancer. Cost-effectiveness has not been assessed yet. An early health technology assessment was performed to estimate costs of MR-HIFU ablation, compared to breast conserving treatment (BCT). METHODS: An MR-HIFU treatment model using the dedicated MR-HIFU breast system (Sonalleve, Philips Healthcare) was developed...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28748092/a-focused-ultrasound-treatment-system-for-moving-targets-part-i-generic-system-design-and-in-silico-first-stage-evaluation
#11
Michael Schwenke, Jan Strehlow, Daniel Demedts, Sabrina Haase, Diego Barrios Romero, Sven Rothlübbers, Caroline von Dresky, Stephan Zidowitz, Joachim Georgii, Senay Mihcin, Mario Bezzi, Christine Tanner, Giora Sat, Yoav Levy, Jürgen Jenne, Matthias Günther, Andreas Melzer, Tobias Preusser
BACKGROUND: Focused ultrasound (FUS) is entering clinical routine as a treatment option. Currently, no clinically available FUS treatment system features automated respiratory motion compensation. The required quality standards make developing such a system challenging. METHODS: A novel FUS treatment system with motion compensation is described, developed with the goal of clinical use. The system comprises a clinically available MR device and FUS transducer system...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28717511/thalamotomy-for-essential-tremor-fda-approval-brings-brain-treatment-with-fus-to-the-clinic
#12
EDITORIAL
Paul S Fishman
No abstract text is available yet for this article.
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28680636/ablative-techniques-for-the-treatment-of-benign-and-malignant-breast-tumours
#13
REVIEW
Mirjam C L Peek, Michael Douek
Minimally invasive techniques like high intensity focused ultrasound, radiofrequency ablation, cryo-ablation, laser ablation and microwave ablation have been used to treat both breast fibroadenomata and breast cancer as an alternative to surgical excision, potentially reducing the complications, improving cosmesis and reducing hospital stay. This review describes the most common minimally invasive techniques available, their history and some of the studies performed with these techniques in both benign and malignant lesions...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28652915/ablation-of-the-sacroiliac-joint-using-mr-guided-high-intensity-focused-ultrasound-a-preliminary-experiment-in-a-swine-model
#14
Elena A Kaye, Majid Maybody, Sebastien Monette, Stephen B Solomon, Amitabh Gulati
BACKGROUND: Dysfunction of the Sacroiliac Joint (SIJ) is one of the key sources of low back pain. For prolonged pain relief, some patients undergo fluoroscopic guided radio-frequency (RF) ablation of SIJ, during which a number of RF probes are inserted to create thermal lesions that disrupt the posterior sacral nerve supply. This procedure is minimally invasive, laborious, time-consuming and costly. To study if High Intensity Focused Ultrasound (HIFU) ablation is a feasible alternative approach to SIJ pain treatment, we performed experiments using HIFU to ablate SIJ in the swine model...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28616236/effect-of-applied-energy-in-renal-sympathetic-denervation-with-magnetic-resonance-guided-focused-ultrasound-in-a-porcine-model
#15
Jill Shea, Joshua de Bever, Eugene Kholmovski, Hannah Beal, J Rock Hadley, Emilee Minalga, Mohamed E Salama, Nassir F Marrouche, Allison Payne
BACKGROUND: Past catheter-based and focused ultrasound renal denervation studies have indicated that procedure efficacy is related to the number of ablations performed or the amount of energy used for the ablation. This study extends those prior results and investigates energy level effects on the efficacy of MR guided focused ultrasound renal denervation performed in a porcine model. METHODS: Twenty-four normotensive pigs underwent unilateral denervation at three intensity levels...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28572977/acoustic-and-thermal-characterization-of-agar-based-phantoms-used-for-evaluating-focused-ultrasound-exposures
#16
Georgios Menikou, Christakis Damianou
BACKGROUND: This study describes a series of experimental work completed towards characterizing candidate materials for fabricating brain and muscle tissue mimicking phantoms. METHODS: The acoustic speed, attenuation, impedance, thermal diffusivity, specific heat and thermal conductivity were measured. RESULTS: The resulting brain (2% w/v agar-1.2% w/v Silica Dioxide-25%v/v evaporated milk) and muscle tissue recipe (2% w/v agar-2% w/v Silica Dioxide-40%v/v evaporated milk) introduced a total attenuation coefficient of 0...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28560040/spatially-segmented-undersampled-mri-temperature-reconstruction-for-transcranial-mr-guided-focused-ultrasound
#17
Pooja Gaur, Beat Werner, Xue Feng, Samuel W Fielden, Craig H Meyer, William A Grissom
BACKGROUND: Volumetric thermometry with fine spatiotemporal resolution is desirable to monitor MR-guided focused ultrasound (MRgFUS) procedures in the brain, but requires some form of accelerated imaging. Accelerated MR temperature imaging methods have been developed that undersample k-space and leverage signal correlations over time to suppress the resulting undersampling artifacts. However, in transcranial MRgFUS treatments, the water bath surrounding the skull creates signal variations that do not follow those correlations, leading to temperature errors in the brain due to signal aliasing...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28523127/high-intensity-focused-ultrasound-hifu-ablation-of-benign-thyroid-nodules-a-systematic-review
#18
REVIEW
Brian Hung-Hin Lang, Arnold L H Wu
BACKGROUND: With an increasing number of imaging studies being done nowadays, the number of incidentally discovered thyroid nodules is expected to rise. Although many of these nodules are small and benign in nature, some do grow and may cause pressure and/or thyrotoxic symptoms. Surgical resection has traditionally been recommended for symptomatic nodules but is associated with risk of hypothyroidism, bleeding, infection, and nerve damage. High intensity focused ultrasound (HIFU) is one of the non-surgical thermal ablation techniques that may serve as an alternative in the treatment of benign thyroid nodules...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28469915/theoretical-investigation-of-transgastric-and-intraductal-approaches-for-ultrasound-based-thermal-therapy-of-the-pancreas
#19
Serena J Scott, Matthew S Adams, Vasant Salgaonkar, F Graham Sommer, Chris J Diederich
BACKGROUND: The goal of this study was to theoretically investigate the feasibility of intraductal and transgastric approaches to ultrasound-based thermal therapy of pancreatic tumors, and to evaluate possible treatment strategies. METHODS: This study considered ultrasound applicators with 1.2 mm outer diameter tubular transducers, which are inserted into the tissue to be treated by an endoscopic approach, either via insertion through the gastric wall (transgastric) or within the pancreatic duct lumen (intraductal)...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28413682/multi-focal-hifu-reduces-cavitation-in-mild-hyperthermia
#20
Vandiver Chaplin, Charles F Caskey
BACKGROUND: Mild-hyperthermia therapy (40-45 °C) with high-intensity focused ultrasound (HIFU) is a technique being considered in a number of different treatments such as thermally activated drug delivery, immune-stimulation, and as a chemotherapy adjuvant. Mechanical damage and loss of cell viability associated with HIFU-induced acoustic cavitation may pose a risk during these treatments or may hinder their success. Here we present a method that achieves mild heating and reduces cavitation by using a multi-focused HIFU beam...
2017: Journal of Therapeutic Ultrasound
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