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Gastroenterology Report

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https://www.readbyqxmd.com/read/29780603/male-gender-is-associated-with-an-increased-risk-of-anastomotic-leak-in-rectal-cancer-patients-after-total-mesorectal-excision
#1
Chi Zhou, Xian-Rui Wu, Xuan-Hui Liu, Yu-Feng Chen, Jia Ke, Xiao-Wen He, Xiao-Sheng He, Tuo Hu, Yi-Feng Zou, Xiao-Bin Zheng, Hua-Shan Liu, Jian-Cong Hu, Xiao-Jian Wu, Jian-Ping Wang, Ping Lan
Background: The impact of a patient's gender on the development of anastomotic leak (AL) in rectal cancer patients following total mesorectal excision (TME) remains controversial. The aim of this study was to evaluate the association between patients' gender and the risk of AL. Methods: All rectal cancer patients following TME with a primary anastomosis during the study period from 2010 to 2014 were examined. Comparisons of the post-operative AL incidence rate between male and female patients were performed...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780602/screening-for-colorectal-cancer-in-tianhe-guangzhou-results-of-combining-fecal-immunochemical-tests-and-risk-factors-for-selecting-patients-requiring-colonoscopy
#2
Yi Liao, Senmao Li, Chunyu Chen, Xuan He, Feng Lin, Jianping Wang, Zuli Yang, Ping Lan
Objective: To explore the performance of a protocol combining fecal immunochemical test (FIT) and a high-risk factor questionnaire (HRFQ) for selecting patients requiring colonoscopy as part of a population-based colorectal cancer (CRC) screening program in China. Methods: From 2015 to 2016, we conducted a CRC screening program for all residents aged 45 years or older in Tianhe District, Guangzhou City, China. Participants underwent an FIT and received an HRFQ as part of primary screening...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780601/a-comparison-of-apache-ii-bisap-ranson-s-score-and-modified-ctsi-in-predicting-the-severity-of-acute-pancreatitis-based-on-the-2012-revised-atlanta-classification
#3
Anubhav Harshit Kumar, Mahavir Singh Griwan
Objective: Our aim was to prospectively compare the Accuracy of Acute Physiology and Chronic Health Evaluation (APACHE) II, Bedside Index of Severity in Acute Pancreatitis (BISAP), Ranson's score and modified Computed Tomography Severity Index (CTSI) in predicting the severity of acute pancreatitis based on Atlanta 2012 definitions in a tertiary care hospital in northern India. Methods: Fifty patients with acute pancreatitis admitted to our hospital during the period of March 2015 to September 2016 were included in the study...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780600/fluoroscopic-gastric-peroral-endoscopic-pyloromyotomy-g-poem-in-patients-with-a-failed-gastric-electrical-stimulator
#4
Abhinav Koul, Sunil Dacha, Parit Mekaroonkamol, Xiaoyu Li, Lianyong Li, Nikrad Shahnavaz, Steven Keilin, Field F Willingham, Jennifer Christie, Qiang Cai
Background: Gastric electrical stimulators (GESs) have been used to treat refractory gastroparesis in patients who fail initial therapies such as dietary modifications, control of psychological stressors and pharmacologic treatment. More recently, gastric peroral endoscopic pyloromyotomy (G-POEM) has emerged as a novel endoscopic technique to treat refractory gastroparesis. We present a case series of patients with refractory gastroparesis who failed treatment with an implanted GES that were safely treated with G-POEM performed under fluoroscopy as a salvage therapy...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780599/perioperative-blood-transfusion-is-associated-with-post-operative-infectious-complications-in-patients-with-crohn-s-disease
#5
Nan Lan, Luca Stocchi, Yi Li, Bo Shen
Background: We have previously demonstrated that blood transfusion (BT) was associated with post-operative complications in patients undergoing surgery for Crohn's disease (CD), based on our institutional data registry. The aim of this study was to verify the association between perioperative BT and infectious complications in CD patients enrolled in the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database. Methods: All CD patients undergoing surgery between 2005 and 2013 were identified from NSQIP...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780598/the-impact-of-surgeon-choices-on-costs-associated-with-uncomplicated-minimally-invasive-colectomy-you-are-not-as-important-as-you-think
#6
John Tillou, Deborah Nagle, Vitaliy Poylin, Thomas Cataldo
Background: There is increasing public discussion about the escalating cost of healthcare in America. There are no published data regarding the contribution of individual surgeons' choices on the cost of uncomplicated minimally invasive colectomy. Methods: A review of a hospital cost-accounting database of the direct costs related to the index operation and post-operative care of all patients who underwent elective minimally invasive segmental colectomy over a 1-year period was performed...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780597/outcomes-and-prognostic-factors-of-fecal-microbiota-transplantation-in-patients-with-slow-transit-constipation-results-from-a-prospective-study-with-long-term-follow-up
#7
Chao Ding, Wenting Fan, Lili Gu, Hongliang Tian, Xiaolong Ge, Jianfeng Gong, Yongzhan Nie, Ning Li
Background and aim: Gut microbiota may contribute to regulate colonic motility, which is involved in the etiology of constipation. Fecal microbiota transplantation (FMT) has been demonstrated to restore intestinal homeostasis. The aim of this study was to evaluate the clinical outcomes and prognostic factors of FMT for the treatment of slow transit constipation (STC). Methods: Fifty-two patients with STC received standardized FMT and were followed up for 6 months...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780596/value-of-routine-stool-testing-for-pathogenic-bacteria-in-the-evaluation-of-symptomatic-patients-with-ileal-pouches
#8
Amandeep Singh, Jean Ashburn, Gursimran Kochhar, Rocio Lopez, Tracy L Hull, Bo Shen
Background: In symptomatic patients with an ileal pouch, stool studies are often sent to diagnose enteric pathogens. Aim of this study is to find the value of routine stool studies in the evaluation of symptomatic patients and the clinical implications of such pathogens in patients with ileal pouches. Methods: Consecutive ileal pouch-anal anastomosis (IPAA) patients who had stool tests out of a 2283-case registry from 2002 to 2015 were included in the study. Patients with positive stool cultures were compared with controls (symptomatic without positive stool culture) in a 1:4 ratio...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780595/early-detection-of-ulcerative-colitis-associated-colorectal-cancer
#9
REVIEW
Yu Zhen, Chengxin Luo, Hu Zhang
Colitis-associated colorectal cancer (CACC) is one of the most serious complications of inflammatory bowel disease (IBD), particularly in ulcerative colitis (UC); it accounts for approximately 15% of all-causes mortality among IBD patients. Because CACC shows a worse prognosis and higher mortality than sporadic colorectal cancer, early detection is critical. Colonoscopy is primarily recommended for surveillance and several advanced endoscopic imaging techniques are emerging. In addition, recent studies have reported on attempts to develop clinically relevant biomarkers for surveillance using various biosamples, which may become high-performance screening tools in the future, so the best approach and technique for cancer surveillance in long-standing UC patients remain under debate...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780594/role-of-endoscopy-in-inflammatory-bowel-disease
#10
REVIEW
Shishira Bharadwaj, Neeraj Narula, Parul Tandon, Mohammad Yaghoobi
Crohn's disease (CD) and ulcerative colitis (UC) constitute the two most common phenotypes of inflammatory bowel disease (IBD). Ileocolonoscopy with biopsy has been considered the gold standard for the diagnosis of IBD. Differential diagnosis of CD and UC is important, as their medical and surgical treatment modalities and prognoses can be different. However, approximately 15% of patients with IBD are misdiagnosed as IBD unclassified due to the lack of diagnostic certainty of CD or UC. Recently, there has been increased recognition of the role of the therapeutic endoscopist in the field of IBD...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479445/variations-in-the-medical-treatment-of-inflammatory-bowel-disease-among-gastroenterologists
#11
Shailendra Singh, Monica Chowdhry, Shifa Umar, Mohammad Bilal, Kofi Clarke
Background and aims: With expanding available treatment options and evolving understanding of the risks and benefits of medical therapies for inflammatory bowel disease (IBD), there is the possibility of significant variations in treatment and outcomes. Little is known about the variation in treatment between IBD specialists and other gastroenterology (GI) physicians. Evaluating possible variations is an important first step to help address standardized care and optimize treatment. We studied the differences in use of biologics and immunomodulators in the management of IBD patients at a tertiary care hospital between IBD-trained physicians and other gastroenterologists...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479444/comparative-analysis-of-different-hepatico-jejunostomy-techniques-for-treating-adult-type-i-choledochal-cyst
#12
Wenjie Ma, Yongqiong Tan, Anuj Shrestha, Fuyu Li, Rongxing Zhou, Junke Wang, Haijie Hu, Qin Yang
Objective: To compare Roux-en-Y hepatico-jejunostomy with complete resection of the cyst or incomplete resection with 1-cm remnant proximal cyst wall in treating adult type I choledochal cyst (CC). Methods: The medical records of 267 adult patients with type I CC from January 1998 to December 2015 were reviewed retrospectively. Among them, 171 underwent Roux-en-Y hepatico-jejunostomy with complete resection (PBD 0-cm group) and 96 underwent Roux-en-Y hepatico-jejunostomy with 1-cm proximal cyst wall left (PBD 1-cm group)...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479443/effects-of-lifestyle-modification-on-liver-enzyme-and-fibroscan-in-indian-patients-with-non-alcoholic-fatty-liver-disease
#13
Jayanta Paul, Raj Vigna Venugopal, Lorance Peter, Shihaz Hussain, Kula Naresh Kumar Shetty, Mohit P Shetti
Background and aims: Non-alcoholic fatty liver disease (NAFLD) is remarkably increasing in developing countries like India, in parallel with the increasing incidence of obesity. Lifestyle modification is a recommended treatment for NAFLD. In most of the previous studies, improvement after lifestyle modification was assessed by liver fibrosis through liver biopsy, but we cannot do a serial liver biopsy in every NAFLD patient. Liver fibrosis can also be assessed by fibroscan non-invasively in NAFLD...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479442/the-efficacy-of-rapid-on-site-evaluation-during-endoscopic-ultrasound-guided-fine-needle-aspiration-of-pancreatic-masses
#14
Abhinav Koul, Anand C Baxi, Ruilian Shang, Xianmei Meng, Lianyong Li, Steven A Keilin, Field F Willingham, Qiang Cai
Background: Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) has become the preferred method to diagnose pancreatic masses due to its minimally invasive approach and diagnostic accuracy. Many studies have shown that rapid on-site evaluation (ROSE) improves diagnostic yield by 10-30%; however, more recent studies have demonstrated effective diagnostic accuracy rates without ROSE. Our study aims to examine whether the current standard of performing ROSE after each FNA pass adds diagnostic value during EUS-guided FNA of pancreatic masses...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479441/ulcerative-colitis-endoscopic-index-of-severity-uceis-versus-mayo-endoscopic-score-mes-in-guiding-the-need-for-colectomy-in-patients-with-acute-severe-colitis
#15
Tingbin Xie, Tenghui Zhang, Chao Ding, Xujie Dai, Yi Li, Zhen Guo, Yao Wei, Jianfeng Gong, Weiming Zhu, Jieshou Li
Background: The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and the Mayo Endoscopic Score (MES) were developed as an objective method of the endoscopic severity in ulcerative colitis (UC); however, it was still unclear whether UCEIS vs MES could guide the need for colectomy in acute severe colitis (ASC). Methods: Consecutive ASC patients between January 2012 and May 2016 were retrospectively evaluated. Demographic data, previous therapy, clinical observations, laboratory parameters, medical therapy and endoscopic assessments were documented...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479440/liver-inclusive-intestinal-transplantation-results-in-decreased-alloimmune-mediated-rejection-but-increased-infection
#16
Guosheng Wu, Ruy J Cruz
Background and aims: A co-transplanted liver allograft has been thought to protect other organs from rejection-mediated injury; however, detailed analyses of co-transplanted liver on intestinal allograft outcomes have not been conducted to date. The aim of the study was to compare immune-mediated injury, causes of graft failure and clinical outcomes between recipients who underwent either a liver-inclusive intestinal transplant (LITx) or liver-exclusive intestinal transplant (LETx). Methods: Between May 2000 and May 2010, 212 adult patients undergoing LITx ( n  =76) and LETx ( n  =136) were included...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479439/treatment-of-recurrent-clostridium-difficile-colitis-a-narrative-review
#17
REVIEW
Roy J Hopkins, Robert B Wilson
Clostridium difficile is a gram-positive, spore-forming, obligate anaerobic bacillus that was originally isolated from the stool of a healthy neonate in 1935. In high-income countries, C. difficile is the most common cause of infectious diarrhoea in hospitalized patients. The incidence of C. difficile infection in the USA has increased markedly since 2000, with hospitalizations for C. difficile infections in non-pregnant adults doubling between 2000 and 2010. Between 20% and 35% of patients with C. difficile infection will fail initial antibiotic treatment and, of these, 40-60% will have a second recurrence...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479438/interventions-to-improve-physical-function-and-prevent-adverse-events-in-cirrhosis
#18
REVIEW
Hirsh D Trivedi, Elliot B Tapper
Cirrhosis is associated with debilitating complications that significantly impact on a patient's physical function and reduce quality of life. Owing to highly prevalent sarcopenia, malnutrition and hepatic encephalopathy, functional impairment or frailty is a common complication of cirrhosis. Frailty in turn increases the patient's risk of hospitalization, accidental falls and fractures, and death. The management of frailty and its associated adverse effects is imperative in improving the overall prognosis of patients with advanced liver disease...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29479437/dysbiosis-of-gut-microbiota-in-promoting-the-development-of-colorectal-cancer
#19
REVIEW
Shaomin Zou, Lekun Fang, Mong-Hong Lee
Gastrointestinal microbiome, containing at least 100 trillion bacteria, resides in the mucosal surface of human intestine. Recent studies show that perturbations in the microbiota may influence physiology and link to a number of diseases, including colon tumorigenesis. Colorectal cancer (CRC), the third most common cancer, is the disease resulting from multi-genes and multi-factors, but the mechanistic details between gut microenvironment and CRC remain poorly characterized. Thanks to new technologies such as metagenome sequencing, progress in large-scale analysis of the genetic and metabolic profile of gut microbial has been possible, which has facilitated studies about microbiota composition, taxonomic alterations and host interactions...
February 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29230300/preoperative-hypoalbuminemia-is-associated-with-an-increased-risk-for-intra-abdominal-septic-complications-after-primary-anastomosis-for-crohn-s-disease
#20
Xuanhui Liu, Xianrui Wu, Chi Zhou, Tuo Hu, Jia Ke, Yufeng Chen, Xiaosheng He, Xiaobin Zheng, Xiaowen He, Jiancong Hu, Min Zhi, Xiang Gao, Pinjin Hu, Xiaojian Wu, Ping Lan
Objective: The aim of this study was to evaluate the impact of preoperative hypoalbuminemia on the development of intra-abdominal septic complications (IASCs) after primary anastomosis for patients with Crohn's disease (CD). Methods: All CD patients undergoing bowel resection with a primary anastomosis during the study period from 2007 to 2015 were enrolled. The association of preoperative hypoalbuminemia (<30 g/L) with the risk for IASCs were assessed using both univariate and multivariate analyses...
November 2017: Gastroenterology Report
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