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Gastroenterology Report

Klaus Gottlieb, Chenxiong Le, Vince Wacher, Joe Sliman, Christine Cruz, Tyler Porter, Stephen Carter
[This corrects the article DOI: 10.1093/gastro/gow048.][This corrects the article DOI: 10.1093/gastro/gow048.].
August 2018: Gastroenterology Report
Yongchang Zheng, Li He, Huayu Yang, Yi Bai, Fucun Xie, Kai Kang, Xuehu Wang
No abstract text is available yet for this article.
August 2018: Gastroenterology Report
Shi Chen, Xi-Jie Chen, Dong-Wen Chen, Jun Xiang, Jun-Sheng Peng
No abstract text is available yet for this article.
August 2018: Gastroenterology Report
Heiying Jin, Yan Chen, Bei Zhang
Objective: The aim of this study was to evaluate the safety and efficacy of three-cavity clearance (TCC) used for the treatment of perianal abscess. Methods: A case-control study of patients with perianal abscess was conducted at the Second and Third Affiliated Hospitals of Nanjing University of Chinese Medicine from June 2013 to March 2016. Clinical data from 46 patients who had TCC were analysed. At the same time, 46 patients had simple incision and drainage and 46 patients had abscess drainage and cutting seton (radical abscess incision); the data from these patients were also analysed...
August 2018: Gastroenterology Report
Savio John, Juan Diego Baltodano, Nilesh Mehta, Katherine Mark, Uma Murthy
Background and aim: Testing for Helicobacter pylori (Hp) infection is recommended for work-up of unexplained iron deficiency anemia (IDA), although the evidence supporting this recommendation is scant. The aim of this study was to investigate the association between Hp infection and unexplained iron deficiency (ID) or IDA in the older adult population without significant upper gastrointestinal source of blood loss. Methods: Retrospective single-center cohort study; 523 out of 1253 consecutive patients who underwent esophagogastroduodenoscopy with no significant upper and/or lower gastrointestinal source for blood loss or risk factors for IDA...
August 2018: Gastroenterology Report
Darshan Kothari, Maarten R Struyvenberg, Michael C Perillo, Ghideon Ezaz, Steven D Freedman, Sunil G Sheth
Background and aims: Patients in the intensive care unit (ICU) with acute pancreatitis (AP) are at risk for extra-pancreatic complications given their severe illness and prolonged length of stay. We sought to determine the rate of extra-pancreatic complications and its effect on length of stay (LOS) and mortality in ICU patients with AP. Methods: We performed a retrospective cohort study of ICU patients admitted to a tertiary-care center with a diagnosis of AP. A total of 287 ICU patients had a discharge diagnosis of AP, of which 163 met inclusion criteria...
August 2018: Gastroenterology Report
Jian-Hong Peng, Jun-Zhong Lin, Yu-Ming Rong, Ying Zhu, Yu-Xiang Deng, Yu-Jie Zhao, Zhen-Hai Lu, Xiao-Jun Wu, Zhi-Zhong Pan
Background: The necessity for adjuvant chemotherapy (ACT) in locally advanced rectal cancer (LARC) patients who achieve pathological complete response (pCR) after pre-operative chemoradiotherapy (CRT) is still not identified. We aimed to investigate the therapeutic value of ACT in these patients. Methods: Clinical data were retrospectively collected from 105 consecutive LARC patients who achieved pCR after pre-operative CRT and underwent radical tumor resection between December 2008 and April 2014 in a comprehensive cancer center...
August 2018: Gastroenterology Report
Tuo Hu, Xianrui Wu, Jiancong Hu, Yufeng Chen, Huashan Liu, Chi Zhou, Xiaowen He, Min Zhi, Xiaojian Wu, Ping Lan
Background: Patients with Crohn's disease (CD) are often reported to be at a high risk for incisional surgical site infection (SSI). The aim of this study was to identify the risk factors associated with post-operative incisional SSI in CD patients after bowel resection. Method: CD patients undergoing bowel resection between 2007 and 2015 were enrolled. Demographic and clinical features related to post-operative incisional SSI were analysed using both univariate and multivariate logistical analyses...
August 2018: Gastroenterology Report
Freeha Khan, Xian-Hua Gao, Amandeep Singh, Jessica R Philpott, Bo Shen
Background: Our recent study showed the efficacy and safety of vedolizumab in the treatment of chronic antibiotic-refractory pouchitis. However, there are no published studies on its efficacy and safety in Crohn's disease (CD) of the pouch. The aim of this study was to assess the efficacy and safety of vedolizumab in those patients. Methods: This case series included all eligible patients with CD of the pouch from our prospectively maintained, IRB-approved Pouchitis Registry from 2015 to 2017...
August 2018: Gastroenterology Report
Afrin Kamal, Sampurna Shakya, Rocio Lopez, Prashanthi N Thota
Background: High-resolution esophageal manometry (HREM) is the diagnostic test of choice for evaluation of non-obstructive dysphagia. Studies regarding the predictors of esophageal dysmotility are limited. Therefore, our aim was to study the prevalence of and factors associated with esophageal motility disorders in patients with non-obstructive dysphagia. Methods: We performed a retrospective review of all patients with non-obstructive dysphagia who underwent HREM in a tertiary center between 1 January 2014 and 31 December 2015...
August 2018: Gastroenterology Report
Yuan-Yuan Yuan, Ke-Xin Xie, Sha-Long Wang, Lian-Wen Yuan
As an essential part of programmed cell death, pyroptosis is an inflammatory response that is elicited upon infection by intracellular pathogens. Metabolic diseases, atherosclerosis and vital organ damage occur if pyroptosis is over-activated. Macrophages are the main cells that induce pyroptosis with the help of intracellular pattern-recognition receptors stimulated by danger signals and pathogenic microorganisms in the cytosol of host cells. Activated inflammatory caspases induce pyroptosis and produce pro-inflammatory cytokines, such as interleukin-1β and interleukin-18...
August 2018: Gastroenterology Report
Alexander W W Brown, Robert B Wilson
Clostridium difficile is a major cause of hospital-associated diarrhoea, and in severe cases leads to pseudomembranous colitis and toxic megacolon. The frequency of C. difficile infection (CDI) has increased in recent decades, with 453 000 cases identified in 2011 in the USA. This is related to antibiotic-selection pressure, disruption of normal host intestinal microbiota and emergence of antibiotic-resistant C. difficile strains. The burden of community-acquired CDI has been increasingly appreciated, with disease identified in patients previously considered low-risk, such as young women or patients with no prior antibiotic exposure...
August 2018: Gastroenterology Report
Chi Zhou, Xian-Rui Wu, Xuan-Hui Liu, Yu-Feng Chen, Jia Ke, Xiao-Wen He, Xiao-Sheng He, Tuo Hu, Yi-Feng Zou, Xiao-Bin Zheng, Hua-Shan Liu, Jian-Cong Hu, Xiao-Jian Wu, Jian-Ping Wang, Ping Lan
Background: The impact of a patient's gender on the development of anastomotic leak (AL) in rectal cancer patients following total mesorectal excision (TME) remains controversial. The aim of this study was to evaluate the association between patients' gender and the risk of AL. Methods: All rectal cancer patients following TME with a primary anastomosis during the study period from 2010 to 2014 were examined. Comparisons of the post-operative AL incidence rate between male and female patients were performed...
May 2018: Gastroenterology Report
Yi Liao, Senmao Li, Chunyu Chen, Xuan He, Feng Lin, Jianping Wang, Zuli Yang, Ping Lan
Objective: To explore the performance of a protocol combining fecal immunochemical test (FIT) and a high-risk factor questionnaire (HRFQ) for selecting patients requiring colonoscopy as part of a population-based colorectal cancer (CRC) screening program in China. Methods: From 2015 to 2016, we conducted a CRC screening program for all residents aged 45 years or older in Tianhe District, Guangzhou City, China. Participants underwent an FIT and received an HRFQ as part of primary screening...
May 2018: Gastroenterology Report
Anubhav Harshit Kumar, Mahavir Singh Griwan
Objective: Our aim was to prospectively compare the Accuracy of Acute Physiology and Chronic Health Evaluation (APACHE) II, Bedside Index of Severity in Acute Pancreatitis (BISAP), Ranson's score and modified Computed Tomography Severity Index (CTSI) in predicting the severity of acute pancreatitis based on Atlanta 2012 definitions in a tertiary care hospital in northern India. Methods: Fifty patients with acute pancreatitis admitted to our hospital during the period of March 2015 to September 2016 were included in the study...
May 2018: Gastroenterology Report
Abhinav Koul, Sunil Dacha, Parit Mekaroonkamol, Xiaoyu Li, Lianyong Li, Nikrad Shahnavaz, Steven Keilin, Field F Willingham, Jennifer Christie, Qiang Cai
Background: Gastric electrical stimulators (GESs) have been used to treat refractory gastroparesis in patients who fail initial therapies such as dietary modifications, control of psychological stressors and pharmacologic treatment. More recently, gastric peroral endoscopic pyloromyotomy (G-POEM) has emerged as a novel endoscopic technique to treat refractory gastroparesis. We present a case series of patients with refractory gastroparesis who failed treatment with an implanted GES that were safely treated with G-POEM performed under fluoroscopy as a salvage therapy...
May 2018: Gastroenterology Report
Nan Lan, Luca Stocchi, Yi Li, Bo Shen
Background: We have previously demonstrated that blood transfusion (BT) was associated with post-operative complications in patients undergoing surgery for Crohn's disease (CD), based on our institutional data registry. The aim of this study was to verify the association between perioperative BT and infectious complications in CD patients enrolled in the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database. Methods: All CD patients undergoing surgery between 2005 and 2013 were identified from NSQIP...
May 2018: Gastroenterology Report
John Tillou, Deborah Nagle, Vitaliy Poylin, Thomas Cataldo
Background: There is increasing public discussion about the escalating cost of healthcare in America. There are no published data regarding the contribution of individual surgeons' choices on the cost of uncomplicated minimally invasive colectomy. Methods: A review of a hospital cost-accounting database of the direct costs related to the index operation and post-operative care of all patients who underwent elective minimally invasive segmental colectomy over a 1-year period was performed...
May 2018: Gastroenterology Report
Chao Ding, Wenting Fan, Lili Gu, Hongliang Tian, Xiaolong Ge, Jianfeng Gong, Yongzhan Nie, Ning Li
Background and aim: Gut microbiota may contribute to regulate colonic motility, which is involved in the etiology of constipation. Fecal microbiota transplantation (FMT) has been demonstrated to restore intestinal homeostasis. The aim of this study was to evaluate the clinical outcomes and prognostic factors of FMT for the treatment of slow transit constipation (STC). Methods: Fifty-two patients with STC received standardized FMT and were followed up for 6 months...
May 2018: Gastroenterology Report
Amandeep Singh, Jean Ashburn, Gursimran Kochhar, Rocio Lopez, Tracy L Hull, Bo Shen
Background: In symptomatic patients with an ileal pouch, stool studies are often sent to diagnose enteric pathogens. Aim of this study is to find the value of routine stool studies in the evaluation of symptomatic patients and the clinical implications of such pathogens in patients with ileal pouches. Methods: Consecutive ileal pouch-anal anastomosis (IPAA) patients who had stool tests out of a 2283-case registry from 2002 to 2015 were included in the study. Patients with positive stool cultures were compared with controls (symptomatic without positive stool culture) in a 1:4 ratio...
May 2018: Gastroenterology Report
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