Phillip G Pierce, Brian E Hartnett, Tosha M Laughlin, Joy M Blain, Stephen J Mayclin, Madison J Bolejack, Janette B Myers, Tate W Higgins, David M Dranow, Amy Sullivan, Donald D Lorimer, Thomas E Edwards, Timothy J Hagen, James R Horn, Peter J Myler
The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate and dimethylallyl pyrophosphate. Notably, the MEP pathway is present in bacteria and not in mammals, which makes the enzymes of the MEP pathway attractive targets for discovering new anti-infective agents due to the reduced chances of off-target interactions leading to side effects. There are seven enzymes in the MEP pathway, the third of which is IspD. Two crystal structures of Burkholderia thailandensis IspD (BtIspD) were determined: an apo structure and that of a complex with cytidine triphosphate (CTP)...
February 1, 2024: Acta Crystallographica. Section F, Structural Biology Communications