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Annals of Translational Medicine

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https://www.readbyqxmd.com/read/30499567/early-osteoarthritis-of-the-knee-from-conservative-to-surgical-management
#1
EDITORIAL
Pier Francesco Indelli, Michele Giuntoli
No abstract text is available yet for this article.
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498740/richard-d-sontheimer-inveterate-curiosity-is-the-fundamental-character-trait-of-a-doctors-doctor
#2
Brad Li
No abstract text is available yet for this article.
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498739/interview-with-prof-j%C3%A3-rg-kleeff-during-the-2018-13th-ihpba-congress
#3
Elva S Zheng
No abstract text is available yet for this article.
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498738/early-liver-transplant-for-severe-alcoholic-hepatitis-establishing-a-new-frontier-by-ignoring-the-rule
#4
EDITORIAL
Julie Zhu, Trana Hussaini, Eric M Yoshida
No abstract text is available yet for this article.
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498737/the-application-of-a-single-direction-strategy-in-vats-segmentectomy-left-s3-segmentectomy
#5
Yunke Zhu, Jiandong Mei, Lunxu Liu
A video-assisted thoracoscopic surgery (VATS) segmentectomy is a technical challenge. This is due to the sophisticated anatomical variations in the segmental bronchus and vessels as well as an obscure surgical demarcation(s). For some, a segmentectomy procedure can be regarded as a lobectomy in the situations of the absence of lung fissures. Thus, the strategy of single-direction VATS lobectomy was applied in our VATS segmentectomy practice. After the introduction of this strategy, we presented the single-direction VATS left S3 segmentectomy as an example to introduce the technical characteristics of the single-direction segmentectomy...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498736/solid-organ-transplantation-in-the-21-st-century
#6
REVIEW
Cara K Black, Kareem M Termanini, Oswaldo Aguirre, Jason S Hawksworth, Michael Sosin
Solid organ transplantation (SOT) has emerged from an experimental approach in the 20th century to now being an established and practical definitive treatment option for patients with end-organ dysfunction. The evolution of SOT has seen the field progress rapidly over the past few decades with incorporation of a variety of solid organs-liver, kidney, pancreas, heart, and lung-into the donor pool. New advancements in surgical technique have allowed for more efficient and refined multi-organ procurements with minimal complications and decreased ischemic injury events...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498735/correlations-of-soluble-osteoclast-associated-receptor-soscar-with-acute-coronary-syndrome
#7
Qing Zhang, Wei Qiao, Lei Zhou, Hui Jin, Kou-Long Zheng, Dong-Sheng Zhao, Hui-He Lu
Background: An osteoclast-associated receptor (OSCAR) is an immunoglobulin receptor expressed in an osteoclast, and takes part in the formation of an osteoclast. While the soluble OSCAR (sOSCAR) component is reported to be involved in the pathogenesis of arteriosclerosis, the aim of this present study is to investigate the relationship between sOSCAR and acute coronary syndrome (ACS). Methods: This study enrolled 41 patients with ACS and 33 patients without ACS as a control, from March 2017 to June 2017...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498734/surgery-for-advanced-non-small-cell-lung-cancer-patient-after-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-neoadjuvant-therapy
#8
Ye Ning, Minwei Bao, Xiaoxia Yan, Dong Xie, Gening Jiang
Background: This study aimed to evaluate the survival of the advanced non-small cell lung cancer (NSCLC) patients underwent salvage surgeries after EGFR-TKI neoadjuvant therapies. Methods: From 2014 to 2016, 10 patients diagnosed as advanced stage NSCLC (N2 metastasis or great vessels invasion) who responded to EGFR-TKI neoadjuvant therapy were recruited in this study. All patients underwent surgeries and consented the follow-up study. Results: All patients received successful radical surgeries (complete resection of the tumor with systematic lymphadenectomy)...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498733/an-update-of-circulating-rare-cell-types-in-healthy-adult-peripheral-blood-findings-of-immature-erythroid-precursors
#9
Stefan Schreier, Suparerk Borwornpinyo, Rachanee Udomsangpetch, Wannapong Triampo
Background: Circulating rare cells (CRCs) are benign or malignant minuscule events in the peripheral blood or other bodily fluids. The detection and quantification of certain CRC types is an invaluable or proposed candidate biomarker for diagnosis, prognosis and prediction of various pathological conditions. The list of CRC types and biomarker applicability thereof continues to expand along with improvements in cell selection technology. Past findings may suggest commonness of healthy donor peripheral blood circulating mature erythroblasts...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498732/clinical-efficacy-of-icotinib-in-patients-with-advanced-nonsquamous-non-small-cell-lung-cancer-with-unknown-egfr-mutation-status-that-failed-to-respond-to-second-line-chemotherapy
#10
Lu Xu, Xin-Hua Xu, Cheng Yuan, Jia-Yu Zhang, Xi Tang, Dian Chen, Xiao-Long Wang, Guang Zeng
Background: Evaluation of the clinical efficacy and safety of icotinib in advanced nonsquamous non-small cell lung cancer (NSCLC) patients with an unknown EGFR mutation who failed to respond to second-line chemotherapy. Methods: Seventy-six cases of advanced nonsquamous NSCLC were involved in this study from seven hospitals from the Hubei province of China. Patients with an unknown EGFR mutation status were treated with Icotinib, at an oral dosage of 125 mg three times daily...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498731/the-effectiveness-of-allogeneic-mesenchymal-stem-cells-therapy-for-knee-osteoarthritis-in-pigs
#11
Tianwei Xia, Fei Yu, Kaijia Zhang, Zongfang Wu, Dongquan Shi, Huajian Teng, Jirong Shen, Xianfeng Yang, Qing Jiang
Background: Intraarticular injection of the mesenchymal stem cells (MSCs) has shown to be successful for treating osteoarthritis (OA). Nevertheless, many studies have been focusing on autologous MSCs. The following study investigates the safety and effectiveness of intraarticular injection of allogenic MSCs in a pig OA model. Methods: Superparamagnetic iron oxide (SPIO) nanoparticles were labelled with bone marrow-derived mesenchymal stem cells (BM-MSCs) to allow cells tracking using magnetic resonance imaging (MRI)...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498730/the-addition-of-3d-printed-models-to-enhance-the-teaching-and-learning-of-bone-spatial-anatomy-and-fractures-for-undergraduate-students-a-randomized-controlled-study
#12
Ai-Min Wu, Kai Wang, Jian-Shun Wang, Chun-Hui Chen, Xin-Dong Yang, Wen-Fei Ni, Yue-Zheng Hu
Background: Whether or not the addition of 3D (three-dimension) printed models can enhance the teaching and learning environment for undergraduate students in regard to bone spatial anatomy is still unknown. In this study, we investigated the use of 3D printed models versus radiographic images as a technique for the education of medical students about bone spatial anatomy and fractures. Methods: The computed tomography (CT) data from four patients, each with a different fracture type (one spinal fracture, one pelvic fracture, one upper limb fracture, and one lower limb fracture), were obtained, and 3D models of the fractures were printed...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498729/surgical-antimicrobial-prophylaxis-in-intensive-care-unit-icu-patients-a-preliminary-observational-retrospective-study
#13
Gary Duclos, Bruno Pastene, Fanny Depeyre, Zoé Meresse, Nadim Cassir, Ignacio Martin-Loeches, Sharon Einav, Laurent Zieleskiewicz, Marc Leone
Background: Surgical antimicrobial prophylaxis (SAP) is supported by evidence-based guidelines. Nevertheless, SAP guidelines do not cover all clinical scenarios. To our knowledge, no information is available regarding SAP in the critically ill patients. We designed a retrospective, observational and preliminary study which the objective was to describe our professional practices in intensive care unit (ICU) patients requiring SAP. Methods: All patients admitted for more than 48 h in the ICU and requiring surgery were retrospectively included from January 1st to December 31, 2016...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498728/effect-of-erlotinib-plus-bevacizumab-on-brain-metastases-in-patients-with-non-small-cell-lung-cancer
#14
Yasuhiro Chikaishi, Masatoshi Kanayama, Akihiro Taira, Yusuke Nabe, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Ayako Hirai, Koji Kuroda, Naoko Imanishi, Yoshinobu Ichiki, Fumihiro Tanaka
Background: The standard therapy for brain metastasis (BM) in non-small cell lung cancer (NSCLC) is radiation therapy (RT), although it is associated with complications such as leukoencephalopathy. In the current report, we retrospectively review data from eight patients who had NSCLC and harbored epidermal growth factor receptor (EGFR) mutations, and who were received erlotinib plus bevacizumab (E+B) as first-line therapy for BM. Methods: Patients were given E+B as first therapy for BM until August 2017 at our institution...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498727/sole-causal-therapy-worsens-outcome-as-compared-to-no-therapy-and-combined-causal-and-goal-directed-supportive-therapy-in-ovine-septic-shock
#15
Tim-Gerald Kampmeier, Michael Hessler, Philip Helge Arnemann, Martin Westphal, Laura Mareen Seidel, Andrea Morelli, Hugo Van Aken, Sebastian Rehberg, Christian Ertmer
Background: There is clear evidence that early causal therapy improves outcome in sepsis and septic shock, whereas recent studies on supportive hemodynamic therapy have produced very conflictive results. The objective of the present study was to determine whether a supportive hemodynamic therapy guided by clinically relevant invasive monitoring improves survival and organ function in a high-lethality model of septic shock in sheep as compared to sole causal therapy including surgical and antimicrobial treatment...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498726/low-prevalence-of-rheumatoid-arthritis-among-patients-with-pre-existing-type-2-diabetes-mellitus
#16
Anastasios Tentolouris, Anastasia Thanopoulou, Nikolaos Tentolouris, Ioanna Eleftheriadou, Christina Voulgari, Alexandros Andrianakos, Petros P Sfikakis
Background: Type 2 diabetes mellitus (T2DM) is a non-autoimmune disease characterized by chronic hyperglycemia and increased non-enzymatic glycation of amino groups. Glycation occurs through a series of events eventually leading to the formation of irreversible "advanced glycation end-products" (AGEs). AGEs may affect the function of long-lived proteins, including cytokines, immunoglobulins and their receptors, resulting in a "less active" immune system. We aimed to test the hypothesis that a common inflammatory chronic disease, such as rheumatoid arthritis (RA), in which the earliest event is an inflammatory response to unknown stimulus, has a lower prevalence in these patients than in normoglycemic, non-diabetic subjects...
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498725/adjuvant-antiviral-therapy-for-the-prevention-of-hepatocellular-carcinoma-recurrence-after-liver-resection-indicated-for-all-patients-with-chronic-hepatitis-b
#17
EDITORIAL
Clifford Akateh, Timothy M Pawlik, Jordan M Cloyd
No abstract text is available yet for this article.
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30498724/-a-rose-by-any-other-name-does-defining-extreme-phenotypes-add-to-the-management-of-multiple-sclerosis
#18
EDITORIAL
Evan A Jolliffe, Brian G Weinshenker
No abstract text is available yet for this article.
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30460269/is-the-mechanical-power-the-final-word-on-ventilator-induced-lung-injury-we-are-not-sure
#19
EDITORIAL
Francesco Vasques, Eleonora Duscio, Iacopo Pasticci, Federica Romitti, Francesco Vassalli, Michael Quintel, Luciano Gattinoni
No abstract text is available yet for this article.
October 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30460268/is-mechanical-power-the-final-word-on-ventilator-induced-lung-injury-no
#20
EDITORIAL
Robert Huhle, Ary Serpa Neto, Marcus J Schultz, Marcelo Gama de Abreu
Despite being a promising idea that combines several variables related to ventilator-induced lung injury (VILI), the concept of mechanical power (MP) carries a number of limitations, leaves several open questions, lacks proper modelling of positive end-expiratory pressure (PEEP) effects and, more importantly, does not respect the amount of lung tissue subjected to MP. First, the assessment of MP as a measure for development of VILI would have the highest relevance when volume displacement and related pressure changes are measured directly within the lung...
October 2018: Annals of Translational Medicine
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