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Annals of Translational Medicine

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https://www.readbyqxmd.com/read/28758106/neopterin-as-a-biomarker-of-immune-response-in-cancer-patients
#1
REVIEW
Bohuslav Melichar, Martina Spisarová, Marie Bartoušková, Lenka Kujovská Krčmová, Lenka Javorská, Hana Študentová
With the advent of immunotherapy the topic of biomarkers of immune response is of high interest. Along with the expression of programmed death ligand 1 (PD-L1) or tumor infiltrating lymphocytes (TIL), biomarkers of macrophage activation could be of interest. Neopterin is a biomarker of immune activation increased in different disorders associated with immune activation, including cancer. Neopterin synthesis is induced by interferon-γ that also induces indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing catabolism of tryptophan to kynurenine...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758105/epigenetics-of-colorectal-cancer-emerging-circulating-diagnostic-and-prognostic-biomarkers
#2
REVIEW
Elisa Danese, Martina Montagnana
Colorectal cancer (CRC) is one of the most common cancers worldwide and the second leading cause of cancer-related mortality in western countries. Despite the high incidence, treatment options for advanced CRC remain limited and unsuccessful, resulting in a poor prognosis. Therefore, novel accurate diagnostic, prognostic and predictive biomarkers are clearly and urgently needed to detect advanced colon polyps and early stage CRC and to identify the most effective treatments for specific CRC patients. CRC is known to develop from early premalignant lesions to full blown cancer via a multi-step process involving a series of genetic mutations that accumulate over time...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758104/liquid-biopsies-in-lung-cancer-time-to-implement-research-technologies-in-routine-care
#3
REVIEW
Linda Köhn, Mikael Johansson, Kjell Grankvist, Jonas Nilsson
Lung cancer is the leading cause of cancer mortality. A substantial progress in the understanding of lung cancer biology has resulted in several promising targeted therapies for advanced disease. Druggable targets today include point mutations such as EGFR, BRAF and re-arrangements in genes such as ALK and ROS1. Liquid biopsies collecting e.g., circulating tumor DNA (ctDNA) reflects overall tumor information and is not biased by analyzing of only a small fraction of the tumor and is always accessible in contrast to the lung cancer tissue...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758103/circulating-micrornas-as-emerging-non-invasive-biomarkers-for-gliomas
#4
REVIEW
Alessandra Santangelo, Anna Tamanini, Giulio Cabrini, Maria Cristina Dechecchi
No single circulating biomarker has been put to practice for malignant gliomas so far, the most lethal primary brain tumors. Many promising protein biomarkers such as the mutant EGFRvIII or glial fibrillary acidic protein (GFAP) have already been detected in the blood and cerebrospinal fluid (CSF) of patients with gliomas, but their clinical value is still pending validation. Furthermore, these and other proteins seem to lack sufficient sensitivity and specificity required for a successful biomarker in this clinical setting...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758102/circulating-biomarkers-in-epithelial-ovarian-cancer-diagnosis-from-present-to-future-perspective
#5
REVIEW
Martina Montagnana, Marco Benati, Elisa Danese
Ovarian cancer (OC) represents the most lethal gynecological cancer and the poor prognosis is often attributable to late diagnosis. The diagnostic approach to woman presenting with pelvic mass is difficult and differential diagnosis often requires invasive histological examination. Serum CA125 and HE4, as well as the most of the other serum biomarkers discovered and validated, are not sufficiently sensitive and specific to make early diagnosis. Moreover, conflicting results exist about the improvement of diagnostic performance by using multivariate index assays, developed by combining circulating biomarkers with other variables (i...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758101/brca-population-screening-for-predicting-breast-cancer-for-or-against
#6
Giuseppe Lippi, Camilla Mattiuzzi, Martina Montagnana
The pathogenesis of breast cancer, the most frequent female malignancy, entails both genetic and acquired risk factors. Among the various oncogenetic mutations, those involving the BReast Cancer 1 (BRCA1) and BReast Cancer 2 (BRCA2) genes are associated with an extremely high risk of developing breast cancer, with a penetration approximating 70% in women with a positive family history for this malignancy. This important evidence elicits some pragmatic considerations, such as the clinical effectiveness of screening for the most penetrant BRCA mutations in women with or without a positive familial history, but also raises important issues related to the most appropriate clinical management of these patients...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758100/appropriateness-of-tumor-marker-request-a-case-of-study
#7
Massimo Gion, Chiara Trevisiol, Aline S C Fabricio
Appropriateness is crucial to provide efficient and high-quality health services at affordable costs. Laboratory medicine is a sector of special interest for the investigation of inappropriateness, due to the high rate of technological innovation and its pivotal role in many diseases and clinical settings. Some subjective aspects related to either the patient or physician seem to have a major role on inappropriateness rates. Given the psychological impact of cancer on both patients and physicians, tumor markers represent a case of study for appropriateness...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758099/platelet-expression-of-pkcepsilon-oncoprotein-in-myelofibrosis-is-associated-with-disease-severity-and-thrombotic-risk
#8
Elena Masselli, Cecilia Carubbi, Giulia Pozzi, Silvia Martini, Franco Aversa, Daniela Galli, Giuliana Gobbi, Prisco Mirandola, Marco Vitale
BACKGROUND: Myelofibrosis (MF) is the most aggressive Philadelphia-negative chronic myeloproliferative neoplasm (MPN) with high morbidity and mortality due to thrombo-hemorrhagic complications and leukemic transformation. MF is characterized by profound alterations of megakaryocytopoiesis, with consequent abnormalities in platelet number and function. We recently showed that the overexpression of the oncoprotein PKCepsilon plays a key role in the aberrant differentiation of MF megakaryocyte clone and that its levels correlate with disease burden...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758098/mobile-phone-radiofrequency-exposure-has-no-effect-on-dna-double-strand-breaks-dsb-in-human-lymphocytes
#9
Elisa Danese, Giuseppe Lippi, Ruggero Buonocore, Marco Benati, Chiara Bovo, Chiara Bonaguri, Gian Luca Salvagno, Giorgio Brocco, Dirk Roggenbuck, Martina Montagnana
BACKGROUND: The use of mobile phones has been associated with an increased risk of developing certain type of cancer, especially in long term users. Therefore, this study was aimed to investigate the potential genotoxic effect of mobile phone radiofrequency exposure on human peripheral blood mononuclear cells in vitro. METHODS: The study population consisted in 14 healthy volunteers. After collection of two whole blood samples, the former was placed in a plastic rack, 1 cm from the chassis of a commercial mobile phone (900 MHz carrier frequency), which was activated by a 30-min call...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758097/prognostic-value-of-red-blood-cell-distribution-width-in-hepatocellular-carcinoma
#10
REVIEW
Hemant Goyal, Zhi-De Hu
Red blood cell distribution width (RDW) is a simple, inexpensive, routinely measured and automatically reported blood test parameter, which reflects the degree of anisocytosis of red blood cells in peripheral blood. RDW was found to be associated with and retain clinical significance for assessing disease severity and outcomes in a number of hematological and solid malignancies. Motley of interacting clinical and biochemical factors have an impact on the red cell population biology. Malignancies per se can act as a causative factor, or anisocytosis may develop as a result of chronic inflammation...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758096/type-2-diabetes-mellitus-and-risk-of-hepatocellular-carcinoma-spotlight-on-nonalcoholic-fatty-liver-disease
#11
REVIEW
Alessandro Mantovani, Giovanni Targher
The incidence of both type 2 diabetes mellitus (T2DM) and multiple cancer types are rapidly increasing worldwide. Several studies documented that T2DM is closely associated with an increased incidence of cancer. However, while some methodological considerations preclude a definitive association between T2DM and the risk of certain cancers, the relationship between T2DM and increased risk of incident hepatocellular carcinoma (HCC) remains significant even after adjustment for detection bias and reverse causation, indicating that such association is clinically reliable and robust...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758095/clinical-presentation-and-epidemiology-of-brain-tumors-firstly-diagnosed-in-adults-in-the-emergency-department-a-10-year-single-center-retrospective-study
#12
Ivan Comelli, Giuseppe Lippi, Valentina Campana, Franco Servadei, Gianfranco Cervellin
BACKGROUND: Several patients with new onset brain tumors present to the Emergency Department (ED) complaining for new symptoms. Although information exists on symptom prevalence in the entire population of patients with brain tumors, little is known about the clinical presentation in ED. This retrospective study was planned to investigate clinical presentation and epidemiology of brain tumors firstly diagnosed in a large urban ED throughout a 10-year period. METHODS: All medical records of patients aged ≥18 years, discharged from our ED with a diagnosis of brain tumor were retrieved from the electronic hospital database during a 10-year period (2006 to 2015)...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28758094/cancer-diagnostics-current-concepts-and-future-perspectives
#13
Martina Montagnana, Giuseppe Lippi
No abstract text is available yet for this article.
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706935/interview-with-prof-bo-shen-the-current-status-of-pouch
#14
Jessie Zhong, Maxine Feng
No abstract text is available yet for this article.
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706934/hypertensive-disorders-in-pregnancy
#15
EDITORIAL
Wilbert S Aronow
No abstract text is available yet for this article.
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706933/atezolizumab-in-non-small-cell-lung-cancer-the-era-of-precision-immuno-oncology
#16
EDITORIAL
James Chung Hang Chow, Ka Man Cheung, William Chi Shing Cho
No abstract text is available yet for this article.
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706932/atherosclerotic-renal-artery-stenosis
#17
EDITORIAL
Wilbert S Aronow
No abstract text is available yet for this article.
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706931/extracellular-vesicle-isolation-present-and-future
#18
EDITORIAL
Istvan Furi, Fatemeh Momen-Heravi, Gyongyi Szabo
No abstract text is available yet for this article.
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706930/sternal-wound-management-after-bilateral-internal-thoracic-artery-grafting-a-significant-detail
#19
EDITORIAL
Giuseppe Gatti
No abstract text is available yet for this article.
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706929/diabetes-mellitus-and-multivessel-coronary-artery-disease-an-ongoing-battle-for-an-ideal-treatment-strategy
#20
EDITORIAL
Laura S Kerkmeijer, Serdar Farhan, Roxana Mehran, George D Dangas
No abstract text is available yet for this article.
June 2017: Annals of Translational Medicine
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