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Annals of Translational Medicine

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https://www.readbyqxmd.com/read/30105239/a-pursuit-of-better-treatment-in-oncology-the-4th-hong-kong-international-oncology-symposium-2017
#1
Vicky Wong
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30105238/prof-r-stephanie-huang-an-expert-in-pharmacogenomics
#2
Mike Cheung, Tung-Lun Shih
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30105237/dr-cameron-turtle-the-future-of-immunotherapy-is-bright
#3
Brad Li
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30105236/dr-joseph-siu-kie-au-beyond-immunotherapy-discovering-new-possibilities
#4
Mike Cheung
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30105235/precision-oncology-in-liver-cancer
#5
REVIEW
Kevin M Sullivan, Heidi L Kenerson, Venu G Pillarisetty, Kimberly J Riehle, Raymond S Yeung
With the widespread adoption of molecular profiling in clinical oncology practice, many physicians are faced with making therapeutic decisions based upon isolated genomic alterations. For example, epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are effective in EGFR-mutant non-small cell lung cancers (NSCLC) while anti-EGFR monoclonal antibodies are ineffective in Ras-mutant colorectal cancers. The matching of mutations with drugs aimed at their respective gene products represents the current state of "precision" oncology...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30105234/management-of-hormone-receptor-positive-human-epidermal-receptor-2-negative-advanced-or-metastatic-breast-cancers
#6
REVIEW
Roger K C Ngan
Hormone therapy, rather than chemotherapy, is recommended for hormone-receptor positive (HR+), human epidermal receptor 2 negative (HER2-) advanced or metastatic breast cancer (A/MBC) according to the European Society of Medical Oncology (ESMO), American Society of Clinical Oncology (ASCO) and National Comprehensive Cancer Network (NCCN) guidelines, unless in visceral crisis in which chemotherapy is indicated. Hormonal monotherapy of selective estrogen receptor modulator (SERM) or selective estrogen receptor down-regulator (SERD), aromatase inhibitor (AI), or their combination as doublets, used to be the mainstay options as first-line (1L) therapy for most patients...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30105233/stereotactic-body-radiation-therapy-for-lung-spine-and-oligometastatic-disease-current-evidence-and-future-directions
#7
REVIEW
Emma Maria Dunne, Ian Mark Fraser, Mitchell Liu
Stereotactic body radiation therapy (SBRT) also referred to as stereotactic ablative radiotherapy (SABR), is a technique which has emerged over the past two decades due to improvements in radiation technology. Unlike conventional external beam radiotherapy (cEBRT) which traditionally delivers radiation in small doses [approximately 2 Gray (Gy) per fraction] over several weeks, SBRT, typically delivered in one to eight fractions, is a technique whereby potentially ablative doses of radiotherapy (usually 7.5-20 Gy per fraction) can be delivered with steeper dose gradients and sub millimetre precision, minimising risk to surrounding normal tissues...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30105232/skin-cancer-management-updates-on-merkel-cell-carcinoma
#8
REVIEW
Patricia Tai, Joseph Au
There are many different types of skin tumors in the World Health Organization (WHO) classification. The natural course and treatment varies according to the histological type. This review summarizes clinical experience for treatment decision. Contemporary radiotherapy and systemic therapy are improving. Landmark studies for basal cell and Merkel cell carcinomas (MCC) trigger further research and impetus for improving treatment outcome. Avelumab, nivolumab, pembrolizumab, ipilimumab appear to be promising for treatment of advanced MCCs and adjuvant trials are underway...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30105231/turning-point-for-cancer-management
#9
William C S Cho, Joseph S K Au
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094266/telomere-length-is-the-future-in-our-ends
#10
EDITORIAL
Elisa Danese, Giuseppe Lippi
Telomeres, repetitive nucleotide sequences located at the end of each chromosome, play the important function of preserving chromosome stability and preventing molecular contact with neighboring chromosomes. Albeit the concept that telomere length may be a marker of health and disease seems hence counterintuitive, the translation of this clear-cut concept from the bench to the beside has appeared so far less straightforward. In particular, controversial evidence has emerged so far about the fact that telomere length may actually predict morbidity and mortality across many clinical settings...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094265/diamond-study-an-additional-evidence-of-the-interest-of-being-proactive-in-ibd
#11
EDITORIAL
Xavier Roblin, Mathurin Flamant
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094264/is-there-a-beneficial-effect-of-adding-azathioprine-to-adalimumab-in-crohn-s-disease-patients
#12
EDITORIAL
Mark Löwenberg
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094263/suppression-of-monocyte-inflammatory-and-coagulopathy-responses-in-hiv-infection
#13
EDITORIAL
Reena Rajasuriar, Anna C Hearps, Suzanne M Crowe, Joshua J Anzinger, Clovis S Palmer
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094262/the-role-of-dobutamine-stress-echocardiography-based-projected-aortic-valve-area-in-assessing-patients-with-classical-low-flow-low-gradient-aortic-stenosis
#14
EDITORIAL
Mohinder R Vindhyal, Paul M Ndunda, Zaher Fanari
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094261/-remote-myokine-protects-from-pulmonary-ischemia-reperfusion-injury-by-a-surprising-proximal-control-mechanism
#15
EDITORIAL
Jürgen Bernhagen
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094260/professor-bing-peng-there-is-no-shortcut-to-anywhere-you-want-to-go
#16
Chen Gao
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094259/professor-sebastian-brandner-the-next-frontiers-of-molecular-diagnostics-of-brain-tumours-interrogating-epigenetic-profiles-of-brain-tumours
#17
Anne Lu
No abstract text is available yet for this article.
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094258/management-of-ruptured-liver-segment-iv-hepatocellular-carcinoma-is-transarterial-embolization-tae-superior-to-chemoembolization-tace-the-jury-is-still-out
#18
Anargyros Bakopoulos, Nikolaos Koliakos, Diamantis I Tsilimigras, Dimitrios Schizas, Demetrios Moris, Argiris Angelopoulos, Spyridon Spanakos, Eleftherios Spartalis, Pavlos Patapis, Panagiotis Skandalakis, Theodoros Troupis
HCC rupture is a potentially life-threatening complication owing to underlying vascular dysfunction and coagulopathy. There is still a debate in the literature concerning the best approach in patients presenting in the emergency setting with shock due to spontaneous HCC rupture. In the current report, we describe the case of a 66-year-old female patient with ruptured HCC who was treated successfully by emergency transarterial embolization (TAE) with complete response proved by gradual shrinkage of the tumor...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094257/-dusp2-methylation-is-a-candidate-biomarker-of-outcome-in-head-and-neck-cancer
#19
Cristiana Lo Nigro, Daniela Vivenza, Nerina Denaro, Laura Lattanzio, Mirella Fortunato, Tim Crook, Marco Carlo Merlano
Background: Biomarkers predictive of response to chemoradiotherapy (CRT) regimens for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) are urgently required to identify patients in whom this approach is likely to be effective. TP53 mutations and epidermal growth factor (EGFR) overexpression are common markers of disease. Dual-specificity-phosphatase-2 (DUSP2) has an essential role in cell proliferation, cancer and immune responses. Methods: Aberrant DUSP2 methylation was investigated by pyrosequencing in 5 HNSCC cell lines, 112 LA-HNSCC tumours...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094256/health-related-quality-of-life-measure-distinguishes-between-low-and-high-clinical-t-stages-in-esophageal-cancer
#20
Biniam Kidane, Amir Ali, Joanne Sulman, Rebecca Wong, Jennifer J Knox, Gail E Darling
Background: Functional Assessment of Cancer Therapy-Esophagus (FACT-E) is a health-related quality of life (HRQOL) instrument validated in patients with esophageal cancer. It is made up of both a general component and an esophageal cancer subscale (ECS). Our objective was to explore the relationship between baseline FACT-E, ECS and clinically determined T-stage in patients with stage II-IV cancer of the gastroesophageal junction or thoracic esophagus. Methods: Data from four prospective studies in Canadian academic hospitals were combined...
July 2018: Annals of Translational Medicine
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