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Annals of Translational Medicine

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https://www.readbyqxmd.com/read/28090534/erratum-to-be-care-the-risk-of-under-fit-in-dose-response-meta-analysis-when-using-cubic-spline
#1
(no author information available yet)
[This corrects the article DOI: 10.21037/atm.2016.09.27.].
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090533/professor-julie-mcmullen-love-what-you-do-do-what-you-love
#2
Crystal M Yan
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090532/afatinib-for-patients-with-epidermal-growth-factor-receptor-mutation-positive-non-small-cell-lung-cancer-clinical-implications-of-the-lux-lung-7-study
#3
COMMENT
Keunchil Park
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090531/at-the-crossroads-from-bench-to-bedside-luteolin-is-a-promising-pharmacological-agent-against-myocardial-ischemia-reperfusion-injury
#4
COMMENT
Defeng Pan, Dongye Li
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090530/ck1%C3%AE-an-exploitable-vulnerability-in-breast-cancer
#5
COMMENT
Laura H Rosenberg, John L Cleveland, William R Roush, Derek R Duckett
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090529/is-there-a-role-for-micrornas-as-novel-predictors-of-prognosis-in-myocardial-infarction
#6
COMMENT
Robert Adam, Dominic Kelly
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090528/uncovering-first-molecular-mechanisms-of-secondary-resistance-against-pd-1-blockade
#7
COMMENT
Selma Ugurel
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090527/the-ross-procedure-an-excellent-option-in-the-right-hands
#8
COMMENT
Michael E Bowdish, S Ram Kumar, Vaughn A Starnes
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090526/the-necessity-to-restore-the-anatomic-hip-centre-in-congenital-hip-disease
#9
COMMENT
George A Macheras, Panagiotis Lepetsos, Panagiotis P Anastasopoulos, Spyridon P Galanakos
Total hip replacement (THR) is the treatment of choice for the patient suffering from end-stage hip osteoarthritis. In the presence of deformities due to congenital hip disease (CHD), THR is, in most of the cases, a difficult task, since the technique of performing such an operation is demanding and the results could vary. We present our experience and preferred strategies focusing on challenges and surgical techniques associated with reconstructing the dysplastic hip.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090525/rnas-that-make-a-heart-beat
#10
COMMENT
Mithun Mitra, Hilary A Coller
An increase in stress-associated microRNAs has been observed in the heart after an induced myocardial infarction. Liu and colleagues now demonstrate that one of these stress-associated microRNAs, miR-223-3p, can regulate a component of the voltage-gated channel that mediates rapid outward efflux of potassium during an action potential. Aberrations in the potassium current have been associated with ventricular arrhythmia and heart disease. Strikingly, introducing a small RNA antagonist directed against miR-223-3p into rat hearts, while also inducing a myocardial infarction, resulted in a reduction in arrhythmias...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090524/the-samukeppra-study-in-prehospital-status-epilepticus-lessons-for-future-study
#11
COMMENT
Andrew C Schomer, Jaideep Kapur
In the Lancet Neurology article "Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial" the authors conducted a prehospital, randomized controlled study to determine which treatment is more effective for status epilepticus (SE): benzodiazepine alone, or in combination with levetiracetam (LEV). Although the study had negative results, several aspects of the trial design likely masked any added effect that LEV may have had in controlling SE, including: higher doses of benzodiazepines, lower thresholds for determining cessation of SE, and a smaller sample size...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090523/understanding-the-roles-of-randomized-trials-for-robotic-prostatectomy
#12
EDITORIAL
Alexander P Cole, David F Friedlander, Quoc-Dien Trinh
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090522/lessons-learned-from-battle-2-in-the-war-on-cancer-the-use-of-bayesian-method-in-clinical-trial-design
#13
EDITORIAL
Chul Kim, Giuseppe Giaccone
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090521/big-data-to-the-rescue-of-systemic-inflammatory-response-syndrome-is-electronic-data-mining-the-way-of-the-future
#14
EDITORIAL
Utsav Nandi, Michael A Puskarich, Alan E Jones
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090520/what-should-the-blood-pressure-treatment-goal-be-in-adults-with-hypertension-in-2016
#15
EDITORIAL
Wilbert S Aronow
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090519/a-rare-case-of-a-blood-clot-masquerading-as-a-retained-surgical-drain
#16
Sean Wl Ho, Ivan Th Chua
Surgical drains are commonly used in surgery to reduce post-operative fluid collections. Whilst rare, a retained surgical drain may result in clinical complications and distress to the patient. A retained surgical drain is a potentially avoidable event and surgeons should be aware on how to confirm the presence of a retained surgical drain. We report a rare case of a blood clot masquerading as a retained surgical drain in a patient. The patient is a 55-year-old Malay male who presented with left gluteal necrotizing fasciitis...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090518/clinical-characteristics-and-molecular-pathology-of-skull-ectopic-thyroid-cancer
#17
Longxing Cao, Zhongyong Wang, Jiawei Ma, Jinsheng Chen, Haojiang Zhu, Xiaohua Zhou, Qing Zhu, Jun Dong, Qing Lan, Qiang Huang
Thyroid cancer is very common, but skull ectopic thyroid cancer has not been reported in 50 years of literatures in foreign countries. There are only four cases of the skull ectopic thyroid cancer reported in more than 30 years of domestic literature including the cases in this report. This paper aims to investigate the clinical characteristics and possible molecular mechanisms of this rare disease. Five keywords of "thyroid gland", "ectopic thyroid", "thyroid cancer", "ectopic thyroid cancer" and "metastatic thyroid cancer" were included and 50 years of literatures in the PubMed-MEDLINE and Wanfang database were reviewed...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090517/semi-parametric-regression-model-for-survival-data-graphical-visualization-with-r
#18
EDITORIAL
Zhongheng Zhang
Cox proportional hazards model is a semi-parametric model that leaves its baseline hazard function unspecified. The rationale to use Cox proportional hazards model is that (I) the underlying form of hazard function is stringent and unrealistic, and (II) researchers are only interested in estimation of how the hazard changes with covariate (relative hazard). Cox regression model can be easily fit with coxph() function in survival package. Stratified Cox model may be used for covariate that violates the proportional hazards assumption...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090516/the-interplay-between-genetics-epigenetics-and-environment-in-modulating-the-risk-of-coronary-heart-disease
#19
EDITORIAL
Giuseppe Lippi, Gianfranco Cervellin
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090515/a-systematic-review-of-combinatorial-treatment-with-warming-and-invigorating-drugs-and-levothyroxine-for-hypothyroidism-caused-by-hashimoto-disease
#20
Xiangwen Cheng, Zixiao Wei, Guangde Zhang, Xin Shao, Bo Li, Rui Gao
BACKGROUND: We used the systematic review method to evaluate the clinical efficacy and safety of combinatorial treatment with warming and invigorating drugs and levothyroxine on hypothyroidism caused by Hashimoto thyroiditis (HT). METHODS: We set inclusion and exclusion criteria, searched for studies using electronic databases and manual retrieval, selected studies according to the inclusion and exclusion criteria, and assessed the qualities of the included studies according to the Jadad scale...
December 2016: Annals of Translational Medicine
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