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Therapeutic Advances in Vaccines

journal
https://www.readbyqxmd.com/read/28794879/human-papillomavirus-driven-immune-deviation-challenge-and-novel-opportunity-for-immunotherapy
#1
REVIEW
Sigrun Smola, Connie Trimble, Peter L Stern
It is now recognized that the immune system can be a key component of restraint and control during the neoplastic process. Human papillomavirus (HPV)-associated cancers of the anogenital tract and oropharynx represent a significant clinical problem but there is a clear opportunity for immune targeting of the viral oncogene expression that drives cancer development. However, high-risk HPV infection of the target epithelium and the expression of the E6/E7 oncogenes can lead to early compromise of the innate immune system (loss of antigen-presenting cells) facilitating viral persistence and increased risk of cancer...
June 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28794878/is-immunity-in-cancer-the-key-to-improving-clinical-outcome-report-on-the-international-symposium-on-immunotherapy-the-royal-society-london-uk-12-13-may-2017
#2
EDITORIAL
https://www.readbyqxmd.com/read/28515939/vaccine-against-arteriosclerosis-an-update
#3
REVIEW
Kuang-Yuh Chyu, Paul C Dimayuga, Prediman K Shah
Substantial data from experimental and clinical investigation support the role of immune-mediated mechanisms in atherogenesis, with immune systems responding to many endogenous and exogenous antigens that play either proatherogenic or atheroprotective roles. An active immunization strategy against many of these antigens could potentially alter the natural history of atherosclerosis. This review mainly focuses on the important studies on the search for antigens that have been tested in vaccine formulations to reduce atherosclerosis in preclinical models...
April 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28515938/accounting-for-adjuvant-induced-artifacts-in-the-characterization-of-vaccine-formulations-by-polyacrylamide-gel-electrophoresis
#4
Virginie Jakob, Livia Brunner, Christophe Barnier-Quer, Molly Blust, Nicolas Collin, Lauren Carter, Darrick Carter, Kelly M Rausch, Christopher B Fox
OBJECTIVES: Several vaccine adjuvants comprise complex nano- or micro-particle formulations, such as oil-in-water emulsions. In order to characterize interactions and compatibility of oil-in-water emulsion adjuvants with protein antigens in vaccines, effective protein characterization methods that can accommodate potential interference from high concentrations of lipid-based particles are needed. METHODS: Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is a standard protein characterization technique which is affected by the presence of adjuvants such as oil-in-water emulsions...
April 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28344806/auditory-and-visual-hallucinations-after-influenza-vaccine-a-case-report
#5
Stefania Antoniazzi, Carla Carnovale, Aurelio Sessa, Marta Gentili, Marco Matacena, Maurizia Punginelli, Emilio Clementi, Sonia Radice
No abstract text is available yet for this article.
February 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28344805/utilization-of-cholera-toxin-b-as-a-mucosal-adjuvant-elicits-antibody-mediated-protection-against-s-pneumoniae-infection-in-mice
#6
Kari Wiedinger, Daniel Pinho, Constantine Bitsaktsis
BACKGOUND: The introduction of the pneumococcal conjugate and polysaccharide vaccines have been valuable tools for combating invasive pneumococcal infection in children and healthy adults. Despite the available vaccination strategies, pneumococcal pneumonia and associated diseases continue to cause substantial morbidity and mortality, particularly in individuals with chronic disease and ageing populations. Next-generation pneumococcal vaccines will need to be highly immunogenic across patient populations providing both mucosal and systemic protective immunity...
February 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28344804/multicomponent-meningococcal-b-vaccination-4cmenb-of-adolescents-and-college-students-in-the-united-states
#7
REVIEW
Angelika Banzhoff
Meningococcal disease is rare, easily misdiagnosed, and potentially deadly. Diagnosis in the early stages is difficult and the disease often progresses extremely rapidly. In North America, the incidence of invasive meningococcal disease (IMD) is highest in infants and young children, with a secondary peak in adolescents, a population predominantly responsible for the carriage of disease. Neisseria meningitidis serogroup B (MenB) accounts for a large proportion of meningococcal disease in North America, with documented outbreaks in three universities in the United States (US) during 2008-2013...
February 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/27551430/erratum
#8
(no author information available yet)
[This corrects the article DOI: 10.1177/2051013615599151.].
January 2016: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/27551429/efficacy-of-varicella-vzv-vaccination-an-update-for-the-clinician
#9
Lili Wang, Lucy Zhu, Hua Zhu
Varicella-zoster virus (VZV) infection causes two distinct clinical conditions. Primary varicella infection results in chickenpox, a contagious rash illness typically seen among children. VZV can reactivate years after the initial infection to cause herpes zoster (HZ) and lead to post-herpetic neuralgia, a common complication resulting in persistent pain that may last for years after the zoster rash resolves. A person's risk of having longer lasting and more severe pain associated with HZ increases with age...
January 2016: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/27551428/neisseria-meningitidis-and-streptococcus-pneumoniae-as-leading-causes-of-pediatric-bacterial-meningitis-in-nine-mexican-hospitals-following-3-years-of-active-surveillance
#10
Enrique Chacon-Cruz, Cesar Adrian Martinez-Longoria, Eduardo Llausas-Magana, Antonio Luevanos-Velazquez, Jorge Alejandro Vazquez-Narvaez, Sandra Beltran, Ana Elena Limon-Rojas, Fernando Urtiz-Jeronimo, Jose Luis Castaneda-Narvaez, Francisco Otero-Mendoza, Fernando Aguilar-Del Real, Jesus Rodriguez-Chagoyan, Rosa Maria Rivas-Landeros, Maria Luisa Volker-Soberanes, Rosa Maria Hinojosa-Robles, Patricia Arzate-Barbosa, Laura Karina Aviles-Benitez, Fernando Ivan Elenes-Zamora, Chandra M Becka, Ricardo Ruttimann
OBJECTIVES: Meningococcal meningitis is reported as a rare condition in Mexico. There are no internationally published studies on bacterial causes of meningitis in the country based on active surveillance. This study focuses on finding the etiology of bacterial meningitis in children from nine Mexican Hospitals. METHODS: From January 2010 to February 2013, we conducted a three years of active surveillance for meningitis in nine hospitals throughout Mexico. Active surveillance started at the emergency department for every suspected case, and microbiological studies confirmed/ruled out all potentially bacterial pathogens...
January 2016: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/27551427/intentions-to-receive-a-potentially-available-lyme-disease-vaccine-in-an-urban-sample
#11
Joshua Fogel, Martin Kusz
OBJECTIVES: The only human Lyme disease vaccine of LYMErix was voluntarily removed from the market in the United States in 2002 for a number of reasons. A new human Lyme disease vaccine is currently being developed. We would like any future approved human Lyme disease vaccine to be of interest and marketable to consumers. METHODS: We surveyed 714 participants to determine variables associated with intentions to receive a Lyme disease vaccine. Predictor variables included demographics, protection motivational theory, Lyme disease knowledge, Lyme disease preventive behaviors, beliefs and perceived health...
January 2016: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/26668753/cholera-toxin-b-induced-activation-of-murine-macrophages-exposed-to-a-fixed-bacterial-immunogen
#12
Kari Wiedinger, Heather Romlein, Constantine Bitsaktsis
OBJECTIVES: Previous studies have demonstrated that intranasal administration of inactivated (fixed) Francisella tularensis (iFt) live vaccine strain (LVS) in conjunction with the mucosal adjuvant, cholera toxin B (CTB), provides full protection against subsequent lethal challenge with Ft LVS and partial protection against the more virulent Ft SchuS4 strain. Understanding the mechanisms of CTB-induced immune stimulation that confer protection against Ft will be valuable to the development of an effective vaccine against this highly virulent fatal pathogen...
September 2015: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/26668752/plant-based-vaccines-for-animals-and-humans-recent-advances-in-technology-and-clinical-trials
#13
REVIEW
Natsumi Takeyama, Hiroshi Kiyono, Yoshikazu Yuki
It has been about 30 years since the first plant engineering technology was established. Although the concept of plant-based pharmaceuticals or vaccines motivates us to develop practicable commercial products using plant engineering, there are some difficulties in reaching the final goal: to manufacture an approved product. At present, the only plant-made vaccine approved by the United States Department of Agriculture is a Newcastle disease vaccine for poultry that is produced in suspension-cultured tobacco cells...
September 2015: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/26668751/clinical-development-of-ebola-vaccines
#14
REVIEW
Saranya Sridhar
The ongoing outbreak of Ebola virus disease in West Africa highlighted the lack of a licensed drug or vaccine to combat the disease and has renewed the urgency to develop a pipeline of Ebola vaccines. A number of different vaccine platforms are being developed by assessing preclinical efficacy in animal models and expediting clinical development. Over 15 different vaccines are in preclinical development and 8 vaccines are now in different stages of clinical evaluation. These vaccines include DNA vaccines, virus-like particles and viral vectors such as live replicating vesicular stomatitis virus (rVSV), human and chimpanzee adenovirus, and vaccinia virus...
September 2015: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/26478818/herpes-zoster-epidemiology-management-and-disease-and-economic-burden-in-europe-a-multidisciplinary-perspective
#15
REVIEW
Robert W Johnson, Marie-José Alvarez-Pasquin, Marc Bijl, Elisabetta Franco, Jacques Gaillat, João G Clara, Marc Labetoulle, Jean-Pierre Michel, Luigi Naldi, Luis S Sanmarti, Thomas Weinke
Herpes zoster (HZ) is primarily a disease of nerve tissue but the acute and longer-term manifestations require multidisciplinary knowledge and involvement in their management. Complications may be dermatological (e.g. secondary bacterial infection), neurological (e.g. long-term pain, segmental paresis, stroke), ophthalmological (e.g. keratitis, iridocyclitis, secondary glaucoma) or visceral (e.g. pneumonia, hepatitis). The age-related increased incidence of HZ and its complications is thought to be a result of the decline in cell-mediated immunity (immunosenescence), higher incidence of comorbidities with age and social-environmental changes...
July 2015: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/26478817/safety-efficacy-and-immunogenicity-of-flublok-in-the-prevention-of-seasonal-influenza-in-adults
#16
REVIEW
Manon M J Cox, Ruvim Izikson, Penny Post, Lisa Dunkle
Flublok is the first recombinant hemagglutinin (HA) vaccine licensed by the US Food and Drugs Administration for the prevention of influenza in adults aged 18 and older. The HA proteins produced in insect cell culture using the baculovirus expression system technology are exact analogues of wild type circulating influenza virus HAs. The universal HA manufacturing process that has been successfully scaled to the 21,000L contributes to rapid delivery of a substantial number of doses. This review discusses the immunogenicity, efficacy and safety data from five pivotal clinical studies used to support licensure of trivalent Flublok for adults 18 years of age and older in the United States...
July 2015: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/26288735/group-b-streptococcus-vaccine-state-of-the-art
#17
REVIEW
Annalisa Nuccitelli, C Daniela Rinaudo, Domenico Maione
Group B Streptococcus (GBS) is cause of neonatal invasive diseases as well as of severe infections in the elderly and immune-compromised patients. Despite significant advances in the prevention and treatment of neonatal disease, sepsis and meningitis caused by GBS still represent a significant public health care concern globally and additional prevention and therapeutic strategies against infection are highly desirable. The introduction of national recommended guidelines in several countries to screen pregnant women for GBS carriage and the use of antibiotics during delivery significantly reduced disease occurring within the first hours of life (early-onset disease), but it has had no effect on the late-onset diseases occurring after the first week and is not feasible in most countries...
May 2015: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/26288734/recent-advances-in-the-development-of-vaccines-for-tuberculosis
#18
REVIEW
Mohamed Jawed Ahsan
Tuberculosis (Tb) continues to be a dreadful infection worldwide with nearly 1.5 million deaths in 2013. Furthermore multi/extensively drug-resistant Tb (MDR/XDR-Tb) worsens the condition. Recently approved anti-Tb drugs (bedaquiline and delamanid) have the potential to induce arrhythmia and are recommended in patients with MDR-Tb when other alternatives fail. The goal of elimination of Tb by 2050 will not be achieved without an effective new vaccine. The recent advancement in the development of Tb vaccines is the keen focus of this review...
May 2015: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/26288733/recent-advances-in-immunotherapy-and-vaccine-development-for-peanut-allergy
#19
REVIEW
Katherine Anagnostou
Peanut allergy is a common problem and can be the cause of severe, life-threatening allergic reactions. It rarely resolves, with the majority of patients carrying the disease onto adulthood. Peanut allergy poses a significant burden on the quality of life of sufferers and their families, which results mainly from the fear of accidental peanut ingestion, but is also due to dietary and social restrictions. Current standard management involves avoidance, patient education and provision of emergency medication, for use in allergic reactions, when they occur...
May 2015: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/25984342/two-or-three-primary-dose-regime-for-haemophilus-influenzae-type-b-conjugate-vaccine-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Kiran K Thumburu, Meenu Singh, Rashmi Ranjan Das, Nishant Jaiswal, Amit Agarwal, Ajay Kumar, Harpreet Kaur
Haemophilus influenzae type b (Hib) is an important cause of meningitis and pneumonia in children. Despite the availability of Hib conjugate vaccine, many countries are still to implement it in their immunization schedule. Before introducing the vaccine in routine immunization programs, it is important to know not only the cumulative efficacy but also the efficacy of each vaccine dose. The primary objective of this review is to find whether two primary dose schedule of Hib vaccine is equally efficacious as the standard three primary dose schedule...
March 2015: Therapeutic Advances in Vaccines
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