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Frontiers in Pediatrics

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https://www.readbyqxmd.com/read/29686980/commentary-association-of-breast-milk-fatty-acids-with-allergic-disease-outcomes-a-systematic-review
#1
COMMENT
Chad A Logan, Jon Genuneit
No abstract text is available yet for this article.
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29686979/comparison-of-prevalence-and-outcomes-of-pediatric-acute-respiratory-distress-syndrome-using-pediatric-acute-lung-injury-consensus-conference-criteria-and-berlin-definition
#2
Samriti Gupta, Jhuma Sankar, Rakesh Lodha, Sushil K Kabra
Objectives: Our objective was to compare the prevalence and outcomes of pediatric acute respiratory distress syndrome using the Pediatric Acute Lung Injury Consensus Conference (PALICC) criteria and Berlin definitions. Methods: We screened case records of all children aged 1 month to 17 years of age admitted to the Pediatric Intensive Care Unit (PICU) over a 3-year period (2015-2017) for presence of any respiratory difficulty at admission or during PICU stay...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29686978/novel-aspects-of-renal-magnesium-homeostasis
#3
REVIEW
Paula Giménez-Mascarell, Carlotta Else Schirrmacher, Luis Alfonso Martínez-Cruz, Dominik Müller
Magnesium (Mg2+ ) is indispensable for several vital functions, such as neurotransmission, cardiac conductance, blood glucose, blood pressure regulation, and proper function of more than 300 enzymes. Thus, Mg2+ homeostasis is subject to tight regulation. Besides the fast and immediate regulation of plasma Mg2+ , a major part of Mg2+ homeostasis is realized by a concerted action of epithelial molecular structures that tightly control intestinal uptake and renal absorption. This mechanism is provided by a combination of para- and transcellular pathways...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29686977/a-prototype-exercise-empowerment-mobile-video-game-for-children-with-cancer-and-its-usability-assessment-developing-digital-empowerment-interventions-for-pediatric-diseases
#4
Carol S Bruggers, Sabrina Baranowski, Mathew Beseris, Rachel Leonard, Derek Long, Elizabeth Schulte, Ashton Shorter, Rowan Stigner, Clinton C Mason, Alisa Bedrov, Ian Pascual, Grzegorz Bulaj
Background: Medical advances continue to improve morbidity and mortality of serious pediatric diseases, including cancer, driving research addressing diminished physical and psychological quality of life in children with these chronic conditions. Empowerment enhances resilience and positively influences health, disease, and therapy understanding. We describe the development and usability assessment of a prototype Empower Stars! mobile video game grounded in behavioral and exercise theories with the purpose of coupling physical exercise with empowerment over disease in children with cancer...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29682496/inotropes-for-preterm-infants-50-years-on-are-we-any-wiser
#5
REVIEW
Aisling A Garvey, Elisabeth M W Kooi, Eugene M Dempsey
For almost half a century, inotropes have been administered to preterm infants with the ultimate goal of increasing their blood pressure. A number of trials, the majority of which focused on dopamine administration, have demonstrated increased blood pressure following inotrope administration in preterm infants and have led to continued use of inotropes in our neonatal units. We have also seen an increase in the number of potential agents available to the clinician. However, we now know that hypotension is a much broader concept than blood pressure alone, and our aim should instead be focused on improving end organ perfusion, specifically cerebral perfusion...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29682495/obesity-and-overweight-among-brazilian-early-adolescents-variability-across-region-socioeconomic-status-and-gender
#6
Chris Fradkin, Nadia C Valentini, Glauber C Nobre, João O L Dos Santos
Introduction: As with most emerging nations, Brazil lacks up-to-date data on the prevalence of obesity and overweight among its children. Of particular concern is the lack of data on children in early adolescence, considered by many to be the crucial stage for weight-related healthcare. Objective: To assess regional, socioeconomic, and gender differences in the prevalence of obesity and overweight among Brazilian early adolescents. Methods: A cross-sectional study was conducted on a racially diverse sample of students aged 10-13 years, from schools in three geographic regions (north, northeast, south) ( N  = 1,738)...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29675404/neonatal-hemodynamics-from-developmental-physiology-to-comprehensive-monitoring
#7
REVIEW
Sabine L Vrancken, Arno F van Heijst, Willem P de Boode
Maintenance of neonatal circulatory homeostasis is a real challenge, due to the complex physiology during postnatal transition and the inherent immaturity of the cardiovascular system and other relevant organs. It is known that abnormal cardiovascular function during the neonatal period is associated with increased risk of severe morbidity and mortality. Understanding the functional and structural characteristics of the neonatal circulation is, therefore, essential, as therapeutic hemodynamic interventions should be based on the assumed underlying (patho)physiology...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29675403/commentary-echocardiographic-evaluation-of-hemodynamics-in-neonates-and-children
#8
COMMENT
Yogen Singh
No abstract text is available yet for this article.
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29675402/poor-compliance-with-sepsis-guidelines-in-a-tertiary-care-children-s-hospital-emergency-room
#9
Benjamin Louis Moresco, Clinton Woosley, Morris Sauter, Utpal Bhalala
Objectives: This study aimed to assess factors related to adherence to the Pediatric Advanced Life Support guidelines for severe sepsis and septic shock in an emergency room (ER) of a tertiary care children's hospital. Methods: This was a retrospective, observational study of children (0-18 years old) in The Children's Hospital of San Antonio ER over 1 year with the International Consensus Definition Codes, version-9 (ICD-9) diagnostic codes for "severe sepsis" and "shocks...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29670872/a-challenging-treatment-decision-for-a-rare-association-case-report-of-familial-turcot-syndrome-with-fistulizing-crohn-s-disease
#10
Montserrat Corbera-Hincapie, Genie L Beasley
Turcot syndrome and fistulizing Crohn's disease (CD) are two disease entities that are not usually associated with one another, particularly given the rarity of the former. This is a case of a pediatric patient with fistulizing CD treated with biologic therapy, who was later found to have Turcot syndrome. Management of this rare combination of diseases can present several challenges, as surgical options may be limited and chronic immunosuppression to treat CD may lead to accelerated progression of malignancy in Turcot syndrome...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29670871/echocardiographic-evaluation-of-ventricular-function-for-the-neonatologist-and-pediatric-intensivist
#11
REVIEW
Cécile Tissot, Yogen Singh, Nicole Sekarski
In the neonatal and pediatric intensive care setting, bedside cardiac ultrasound is often used to assess ventricular dimensions and function. Depending upon the underlying disease process, it is necessary to be able to evaluate the systolic and diastolic function of left and or right ventricles. The systolic function of left ventricle is mostly assessed qualitatively on visual inspection "eye-balling" and quantitatively by measuring circumferential fraction shortening or calculating the ejection fraction by Simpson's planimetry...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29670870/adjunctive-therapies-during-extracorporeal-membrane-oxygenation-to-enhance-multiple-organ-support-in-critically-ill-children
#12
REVIEW
Marguerite Orsi Canter, Jessica Daniels, Brian C Bridges
Since the advent of extracorporeal membrane oxygenation (ECMO) over 40 years ago, there has been increasing interest in the use of the extracorporeal circuit as a platform for providing multiple organ support. In this review, we will examine the evidence for the use of continuous renal replacement therapy, therapeutic plasma exchange, leukopheresis, adsorptive therapies, and extracorporeal liver support in conjunction with ECMO.
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29670869/pathogenetic-and-prognostic-factors-for-neonatal-gastric-perforation-personal-experience-and-systematic-review-of-the-literature
#13
Chiara Iacusso, Alessandro Boscarelli, Fabio Fusaro, Pietro Bagolan, Francesco Morini
Introduction: Neonatal gastric perforation (NGP) is a rare entity. Our aim was to report our experience and review the recent literature to characterize NGP, describe associated factors, and define prognostic factors. Materials and methods: Retrospective review of all consecutive patients with NGP treated between June 2009 and December 2017 in a third level pediatric hospital. In addition, a systematic review of Medline and Scopus database was performed using a defined strategy...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29666787/cardiac-output-monitoring-in-preterm-infants
#14
REVIEW
Matthew McGovern, Jan Miletin
Maintaining optimal circulatory status is a key component of preterm neonatal care. Low-cardiac output (CO) in the preterm neonate leads to inadequate perfusion of vital organs and has been linked to a variety of adverse outcomes with heightened acute morbidity and mortality and adverse neurodevelopmental outcomes. Having technology available to monitor CO allows us to detect low-output states and potentially intervene to mitigate the unwanted effects of reduced organ perfusion. There are many technologies available for the monitoring of CO in the preterm neonatal population and while many act as useful adjuncts to aid clinical decision-making no technique is perfect...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29666786/modeling-neuropsychiatric-and-neurodegenerative-diseases-with-induced-pluripotent-stem-cells
#15
REVIEW
Elizabeth A LaMarca, Samuel K Powell, Schahram Akbarian, Kristen J Brennand
Human-induced pluripotent stem cells (hiPSCs) have revolutionized our ability to model neuropsychiatric and neurodegenerative diseases, and recent progress in the field is paving the way for improved therapeutics. In this review, we discuss major advances in generating hiPSC-derived neural cells and cutting-edge techniques that are transforming hiPSC technology, such as three-dimensional "mini-brains" and clustered, regularly interspersed short palindromic repeats (CRISPR)-Cas systems. We examine specific examples of how hiPSC-derived neural cells are being used to uncover the pathophysiology of schizophrenia and Parkinson's disease, and consider the future of this groundbreaking research...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29662873/permissive-hypercapnia-results-in-decreased-functional-vessel-density-in-the-skin-of-extremely-low-birth-weight-infants
#16
Alexandra Francoise Puchwein-Schwepcke, Kristina Schottmayer, Zuzana Mormanová, Jens Dreyhaupt, Orsolya Genzel-Boroviczeny, Ulrich H Thome
Background: Ventilator-induced lung injury with subsequent bronchopulmonary dysplasia remains an important issue in the care of extremely low-birth-weight infants. Permissive hypercapnia has been proposed to reduce lung injury. Hypercapnia changes cerebral perfusion, but its influence on the peripheral microcirculation is unknown. Methods: Data were collected from 12 infants, who were randomized to a permissive high PCO2 target group (HTG) or a control group (CG)...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29651412/editorial-advances-in-health-care-transition-for-patients-with-childhood-onset-chronic-diseases-international-perspectives
#17
EDITORIAL
Yuko Ishizaki, Mitsue Maru, Hirohiko Higashino
No abstract text is available yet for this article.
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29637934/commentary-open-and-laparoscopic-colposuspension-in-girls-with-refractory-urinary-incontinence
#18
COMMENT
Miguel Podesta, Ricardo González
No abstract text is available yet for this article.
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29637062/idiopathic-mast-cell-activation-syndrome-with-associated-salicylate-intolerance
#19
Tobias Rechenauer, Martin Raithel, Thomas Götze, Gregor Siebenlist, Aline Rückel, Hanns-Wolf Baenkler, Arndt Hartmann, Florian Haller, André Hoerning
Idiopathic mast cell activation syndrome can be a rare cause for chronic abdominal pain in children. It remains a diagnosis by exclusion that can be particularly challenging due to the vast variety of possible clinical manifestations. We present a 13-year-old boy who suffered from a multitude of unspecific complaints over a long period of time. In this case, an assessment of mast cell-derived metabolites and immunohistochemical analysis of bioptic specimen was worthwhile. After ruling out, primary (oncologic) and secondary causes for mast cell activation, pharmacologic treatment adapted to the patient's salicylate intolerance resulted in a major relief of symptoms...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29637061/considerations-for-assessing-the-appropriateness-of-high-cost-pediatric-care-in-low-income-regions
#20
REVIEW
Andrew C Argent
It may be difficult to predict the consequences of provision of high-cost pediatric care (HCC) in low- and middle-income countries (LMICs), and these consequences may be different to those experienced in high-income countries. An evaluation of the implications of HCC in LMICs must incorporate considerations of the specific context in that country (population age profile, profile of disease, resources available), likely costs of the HCC, likely benefits that can be gained versus the costs that will be incurred...
2018: Frontiers in Pediatrics
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