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Global Cardiology Science & Practice

Sami Nimer Ghazal, Shady G Ouf
Marfan syndrome is a genetic disease with variable clinical presentation. This case describes a 36-year-old lady who was diagnosed with Marfan syndrome based on revised Ghent criteria. She was found to have bicuspid aortic valve and sensorineural hearing loss. Inferior vena cava stenosis was suspected on echocardiography due to high velocity flow and visualization of a focal narrowing in the inferior vena cava proximal to hepatic vein entry. Inferior vena cava stenosis was confirmed by computed tomography. Echocardiographic features suggestive of inferior vena cava stenosis include detection of a focal narrowing and high turbulent flow, peak velocity > 1...
2015: Global Cardiology Science & Practice
Yasir H Bouchi, Bill D Gogas
The impetus for developing drug-eluting bioresorbable scaffolds (BRS) has been driven by the need for elastic and transient platforms instead of stiff and permanent metallic implants in diseased coronary anatomies. This endeavor would prevent acute recoil or occlusion, allow sealing of post-procedural dissections following acute barotrauma, provide inhibition of in-segment restenosis through efficient drug-elution and would further prepare the vessel to enter a reparative phase following scaffold resorption...
2015: Global Cardiology Science & Practice
Bill D Gogas, Spencer B King, Habib Samady
Bioresorbable polymers and biocorrodible metals are the latest developments in biodegradable materials used in interventional cardiology for the mechanical treatment of coronary atherosclerosis. Poly-L-lactic acid is the most frequently used bioresorbable polymer and initial evidence of feasibility, efficacy and clinical safety following deployment of polymer-based platforms was gained after completion of the first-in-man longitudinal ABSORB registries, Cohorts A and B and ABSORB Extend. In these studies, the biologic interaction of the first-generation Absorb Bioresorbable Vascular Scaffold (BVS) (Abbott Vascular, SC, Calif...
2015: Global Cardiology Science & Practice
Ahmed Afifi, Walid Simry
No abstract text is available yet for this article.
2015: Global Cardiology Science & Practice
Ahmed Hassan, Ahmed ElGuindy, David Antoniucci
No abstract text is available yet for this article.
2015: Global Cardiology Science & Practice
Stefano Ghio, Sandra Schirinzi, Silvia Pica
The pulmonary circulation is a high-flow/low-pressure system, coupled with a flow generator chamber-the right ventricle-, which is relatively unable to tolerate increases in afterload. A right heart catheterization, using a fluid-filled, balloon-tipped Swan-Ganz catheter allows the measurement of all hemodynamic parameters characterizing the pulmonary circulation: the inflow pressure, an acceptable estimate the outflow pressure, and the pulmonary blood flow. However, the study of the pulmonary circulation as a continuous flow system is an oversimplification and a thorough evaluation of the pulmonary circulation requires a correct understanding of the load that the pulmonary vascular bed imposes on the right ventricle, which includes static and dynamic components...
2015: Global Cardiology Science & Practice
Auras R Atreya, Gregory R Giugliano
As the global burden of atrial fibrillation (AF) and its attendant economic impact on the healthcare system surges, there is increasing interest in the secondary prevention of AF with various therapies. Of the several identified risk factors for AF, obesity is an important contributor that may be managed with intensive lifestyle modification. Prior studies have demonstrated the short-term and long-term benefits of weight loss in reduction of AF symptoms. In the LEGACY study [Long-Term Effect of Goal-Directed Weight Management in an Atrial Fibrillation Cohort: A Long-Term Follow-Up Study], the investigators evaluated the long-term effects of a weight management program on AF symptoms...
2015: Global Cardiology Science & Practice
Jassim Al Suwaidi
Shikany et al used data from 17,418 participants in the REGARDS study, a national, population-based, longitudinal study of white and black adults aged ≥ 45 years, enrolled between 2003-2007. They examined 536 acute coronary heart disease events at follow-up (median 5.8 years) in relation to five dietary patterns (Convenience, Plant-based, Sweets, Southern, and Alcohol and Salad). After adjustment for baseline variables, the highest consumers of the Southern pattern experienced a 56% higher hazard for acute CHD...
2015: Global Cardiology Science & Practice
Kerolos Wagdy, Mohamed ElMaghawry
Takotsubo cardiomyopathy (TTC) is an acute cardiac condition characterized by transient left ventricular dysfunction with wall motion abnormalities, most commonly in the form of apical ballooning. Despite being considered as a generally benign condition, many studies have emphasized potentially sinister outcomes associated with TTC. In this article, we review the most recent results of the International Takotsubo Registry, which investigated the clinical features, prognostic predictors, and outcomes of 1750 patients...
2015: Global Cardiology Science & Practice
(no author information available yet)
No abstract text is available yet for this article.
2015: Global Cardiology Science & Practice
Ulrich Sigwart
Surgical treatment of coronary heart disease has shown its life saving benefits in millions of patients for more than half a century. Attempts to create less invasive ways to achieve similar results have attracted great attention since the introduction of balloon angioplasty in 1977. The fascination with such techniques was hampered by a 30% recurrence rate and a 5% rate of abrupt closure, requiring emergency bypass surgery in most instances. Angioplasty lost much of its unpredictability with the introduction of stents in 1986...
2015: Global Cardiology Science & Practice
Alkistis Kapelouzou, Loukas Tsourelis, Loukas Kaklamanis, Dimitrios Degiannis, Nektarios Kogerakis, Dennis V Cokkinos
BACKGROUND: Calcific aortic valve stenosis (CAVS) is seen in a large proportion of individuals over 60 years. It is an active process, influenced by lipid accumulation, mechanical stress, inflammation, and abnormal extracellular matrix turnover. Various biomarkers (BMs) are studied, as regards mechanisms, diagnosis and prognosis. METHODS: In the calcified valves calcium deposition, elastin fragmentation and disorganization of cellular matrix were assessed, together with expression of OPN, OPG, osteocalcin (OCN) and RL2...
2015: Global Cardiology Science & Practice
Karim Said
It is believed that simultaneous targeting of two or more of the three pathogenic pathways of pulmonary arterial hypertension (the endothelin, nitric oxide, and prostacyclin pathways) is associated with additive or synergistic effects with subsequent increasing efficacy and improving outcomes. However, there is lack of evidence to guide the use of combination strategy among pulmonary arterial hypertension patients and many questions remain to be answered. One of these vital questions is whether the strategy of upfront initiation of combination therapy could improve patients outcomes compared to the strategy of initial monotherapy...
2015: Global Cardiology Science & Practice
Mark L Ormiston, Paul D Upton, Wei Li, Nicholas W Morrell
Human genetic discoveries offer a powerful method to implicate pathways of major importance to disease pathobiology and hence provide targets for pharmacological intervention. The genetics of pulmonary arterial hypertension (PAH) strongly implicates loss-of-function of the bone morphogenetic protein type II receptor (BMPR-II) signalling pathway and moreover implicates the endothelial cell as a central cell type involved in disease initiation. We and others have described several approaches to restore BMPR-II function in genetic and non-genetic forms of PAH...
2015: Global Cardiology Science & Practice
Walid Simry, Ahmed Afifi, Hatem Hosny, Ahmed Elguindy, Magdi Yacoub
We report on a young adult with ALCAPA, who was successfully resuscitated after collapsing in ventricular fibrillation while playing football. This was followed by anatomical correction of the anomaly with a smooth recovery and return to his daily activities. The advantages of this approach are discussed in this brief report.
2015: Global Cardiology Science & Practice
Heba Aguib, Ryo Torii, Soha Romeih, Magdi Yacoub
No abstract text is available yet for this article.
2015: Global Cardiology Science & Practice
Hussam Suradi, Ziyad M Hijazi
Coarctation of the aorta (C) is the sixth most common lesion in congenital heart disease and represents a spectrum of aortic narrowing that varies from a discrete entity to tubular hypoplasia. This condition was once thought to be a relatively simple lesion that would be "cured" upon repair of the narrowing, however, despite relief of the anatomical obstruction the subsequent risk of early morbidity and death persists. This review outlines the optimal management strategy of this disease from neonatal to adult life and provides insights to approach this straightforward but challenging condition...
2015: Global Cardiology Science & Practice
Shiekh Mohammed Shariful Islam, Akm Mainuddin, Md Serajul Islam, Mohammad Azizul Karim, Sabrina Zaman Mou, Shamsul Arefin, Kamrun Nahar Chowdhury
BACKGROUND: Hypertension is a major risk factor for several cardiovascular diseases (CVD). The prevalence of hypertension is increasing in Bangladesh, especially in urban areas. The objective of this study was to estimate the prevalence of hypertension and its risk factors in an urban area of Bangladesh. METHODS: We conducted a cross-sectional survey involving participants aged ≥ 25 years in an urban area in Dhaka between June-December 2012, using multi-stage random sampling...
2015: Global Cardiology Science & Practice
Hisham Dokainish, Esam Elbarasi, Simona Masiero, Caroline Van de Heyning, Michela Brambatti, Sami Ghazal, Said Al-Maashani, Alessandro Capucci, Lisanne Buikema, Darryl Leong, Bharati Shivalkar, Johan Saenen, Hielko Miljoen, Carlos Morillo, Syam Divarakarmenon, Guy Amit, Sebastian Ribas, Aaron Brautigam, Erika Baiocco, Alessandro Maolo, Andrea Romandini, Simone Maffei, Stuart Connolly, Jeff Healey
Given the increasing numbers of cardiac device implantations worldwide, it is important to determine whether permanent endocardial leads across the tricuspid valve can promote tricuspid regurgitation (TR). Virtually all current data is retrospective, and indicates a signal of TR being increased after permanent lead implantation. However, the precise incidence of moderate or greater TR post-procedure, the exact mechanisms (mechanical, traumatic, functional), and the hemodynamic burden and clinical effects of this putative increase in TR, remain uncertain...
2015: Global Cardiology Science & Practice
A Balbaa, A ElGuindy, D Pericak, M H Yacoub, J D Schwalm
BACKGROUND: Although essentially disappeared from the industrialized world, rheumatic heart disease (RHD) is still prevalent in developing countries, with 300,000 new cases identified each year. In Aswan, Egypt, RHD affects about 2.3% of children with over 90% of the cases being subclinical. Secondary prophylaxis has proved to be an effective method of preventing the progression of RHD. However, its efficacy is limited by low patient adherence. A systematic, generalizable tool is necessary to outline, and ultimately address these barriers...
2015: Global Cardiology Science & Practice
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