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Medical Hypothesis, Discovery and Innovation in Ophthalmology

Ali Riza Cenk Celebi
The objective of this study was to assess knowledge and awareness of glaucoma in subjects with glaucoma and their normal first-degree relatives. Awareness and knowledge of glaucoma were compared between each patient and his/her relative. We designed a questionnaire containing a set of brief and structured questions to gather information regarding the participants' demographics and knowledge and awareness of glaucoma. There were two groups in this study. The first group ("glaucoma" group) comprised patients diagnosed with glaucoma, while the second group ("relatives" group) consisted of the first-degree relatives of the patients...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Shahrokh Ramin, Azad Sangin Abadi, Farideh Doroodgar, Mehrdad Esmaeili, Faizollah Niazi, Sana Niazi, Cyrus Alinia, Yaser Golestani, Reza Taj Abadi
This study was performed to evaluate the visual, refractive, and aberration measurement results of 2 implants, including Intacs Intracorneal Ring Segments (ICRS) and phakic Toric Implantable Collamer Lens (TICL), in patients with moderate Keratoconus (KCN). In this retrospective cross-sectional study, 30 patients with KCN with a mean age of 29.83 years were included in 2 groups, including the Intacs Intracorneal Ring Segments (ICRS) group and the phakic Toric Implantable Collamer Lens (TICL) group. Preoperative data as well as 6-month, 1-, 2-, 3- and 4-year follow-up data after the operation were collected and analyzed with the SPSS software (ver...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Efthymios Karmiris, Nikos Kourtis, Malena P Pantou, Dimitris Degiannis, Ilias Georgalas, Dimitrios Papaconstantinou
The purpose of the current study was to identify the potential association between Single Nucleotide Polymorphism (SNP) TGFβ1 +915 (C or G) in codon 25 and Primary Open Angle Glaucoma (POAG). Overall, 88 cases with POAG and a control group of 52 healthy individuals were recruited from the First Ophthalmology Department of Athens University. DNA was isolated from whole blood samples and genotype frequencies for the polymorphism rs1800471 (G915C, Arg25Pro) of the TGF-β1 gene were assessed. Genotype distribution frequencies for the polymorphism rs1800471 (G915C, Arg25Pro) of the TGF-β1 gene were not statistically different between patients with POAG and control subjects...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Mohammad Reza Pishnamaz, Hadi Ostadimoghaddam
Measurement of Visual Acuity (VA) has been used for eye examinations under various clinical conditions. In addition, because of changes in VA with a range of eye diseases, its measurement is used to screen, diagnose, and evaluate response to treatment in numerous eye diseases and predict the patient's visual function. VA and the likelihood of astigmatism could be evaluated simultaneously using a newly designed Stripped Circle (SC) VA chart. This chart has been developed based on the standard VA measurement scale chart, and the Landolt-C (LC) VA chart and all the standards for a VA chart design were implemented during its development...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Hossein Jamali, Vahid Beigi, Ali Sadeghi-Sarvestani
Heredity plays an important role in keratoconus (KC). Consanguineous marriage (CM) can affect the transmission of recessively inherited conditions. We aimed to investigate the role of consanguineous marriage in the development of KC. This study included two groups: the first group comprised 415 patients who underwent surgery for KC for the first time at Khalili University Hospital (Shiraz, Iran), between 2010 and 2014; the second group comprised 415 healthy individuals who served as age- and sex-matched controls for the patient group...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Ayse Gul Kocak Altintas, Bayram Gulpamuk, Veysel Cankurtaran, Cagri Ilhan, Mehmet Citirik
This study aimed at evaluating the correlation between changes in Hemoglobin A1c (HbA1c) and fasting serum lipids, and Central Macular Thickness (CMT) in patients with Non-Proliferative Diabetic Retinopathy (NPDR). In the current research, both eyes of 68 patients with mild or moderate NPDR, without clinically significant macular edema, were studied. Levels of fasting serum lipids, HbAlc, and CMT were measured during the first visit and at the end of the follow-up period (3 months). For statistical analysis, CMTs of each eye were studied and the correlation of changes was investigated...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Majid Moshirfar, Jordan D Desautels, Brian D Walker, Michael S Murri, Orry C Birdsong, Phillip C Hoopes
Laser vision correction is a safe and effective method of reducing spectacle dependence. Photorefractive Keratectomy (PRK), Laser In Situ Keratomileusis (LASIK), and Small-Incision Lenticule Extraction (SMILE) can accurately correct myopia, hyperopia, and astigmatism. Although these procedures are nearing optimization in terms of their ability to produce a desired refractive target, the long term cellular responses of the cornea to these procedures can cause patients to regress from the their ideal postoperative refraction...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Nicolás Crim, Raúl Velez-Montoya, Virgilio Morales-Canton
We aimed to compare the results of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling, an alternative therapeutic strategy, with those of medical treatment for chronic macular edema. We conducted a review of the literature on the microscopic, anatomical, and functional reasons for performing PPV with ILM peeling in patients with diabetic macular edema (DME). We searched the PubMed database for articles published between 2000 and 2017. We used the medical subject heading "vitrectomy diabetic macular edema" and the keywords "diabetic macular edema", "internal limiting membrane peeling", "pars plana vitrectomy", "diabetic retinopathy", and "optical coherence tomography"...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Bahram Khosravi, Masoud Khorrami-Nejad, Sattar Rajabi, Mohamad Amiri, Hesam Hashemian, Mehdi Khodaparast
Considering the rising number of MyoRing implantation procedures in keratoconic corneas and the refractive outcomes associated with this treatment modality, this study aimed to evaluate and compare the magnitude and axis orientation of total and corneal astigmatism between before and after MyoRing implantation in 34 eyes of 28 patients with keratoconus (KCN) (mean age: 29.41 ± 7.0 years). The inclusion criterion was a reliable diagnosis of clinical KCN based on corneal biomicroscopic and tomographic findings...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Shahram Bamdad, Vahid Beigi, Mohammad Reza Sedaghat
Perimetry is one of the mainstays in glaucoma diagnosis and treatment. Various strategies offer different accuracies in glaucoma testing. Our aim was to determine and compare the diagnostic sensitivity and specificity of Swedish Interactive Threshold Algorithm (SITA) Fast and Standard Full Threshold (SFT) strategies of the Humphrey Field Analyzer (HFA) in identifying patients with visual field defect in glaucoma disease. This prospective observational case series study was conducted in a university-based eye hospital...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Masood Bagheri, Zahra Rashe, Mohammad Hosein Ahoor, Mohammad Hosein Somi
Helicobacter pylori is a prevalent cause of gastrointestinal infections. Recently, several studies have shown a relationship between H. pylori infection and a variety of extradigestive manifestations. The aim of this study was to review the literature regarding the prevalence of this infection in cases of central serous chorioretinopathy (CSR). We reviewed the EMBASE, Cochrane Library, and Google Scholar search engines; hand-searched many journals; and searched the cited references in published articles for relevant studies...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Farshad Ostadian, Mahmoud-Reza Panahi-Bazaz, Seyed Mohsen Moosazadeh, Saeed Hesam
We aimed to compare the effect of accelerated and conventional corneal collagen cross-linking (CXL) on visual, refractive, and topographic parameters in patients with progressive keratoconus. Between December 2014 and February 2016, at Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Iran, we compared 37 eyes of 21 patients treated by conventional CXL (CCXL; 3 mW/cm2 in 30 minutes) with 34 eyes of 18 patients treated by accelerated CXL (ACXL; 18 mW/cm2 in 5 minutes) based on generalizing estimation equation analysis in terms of corrected distance visual acuity (CDVA), uncorrected distance visual acuity (UDVA), corneal endothelial cell indices, and topographic parameters before and at 3, 6 and 12 months after the operation...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Ming Chen, Maile Miki, Szuyuan Lin, So Yung Choi
The purpose of this study was to identify which of the eye solutions is best for sodium fluorescein staining of the cornea to diagnose dry eye disease. The study included 173 eyes with suspected or known dry eye disease. The eyes were stained sequentially with sodium fluorescein and each of the following four conditions: balanced salt solution (BSS); BSS and cyclosporine 0.05% emulsion; BSS and lipids containing omega-3; and BSS, cyclosporine 0.05% emulsion, and lipids containing omega-3. Our results showed that compared to BSS alone, artificial tears with cyclosporine 0...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Azadeh Doozandeh, Farnoosh Irandoost, Ali Mirzajani, Shahin Yazdani, Mohammad Pakravan, Hamed Esfandiari
This study aimed to compare second-generation frequency-doubling technology (FDT) perimetry with standard automated perimetry (SAP) in mild glaucoma. Forty-seven eyes of 47 participants who had mild visual field defect by SAP were included in this study. All participants were examined using SITA 24-2 (SITA-SAP) and matrix 24-2 (Matrix-FDT). The correlations of global indices and the number of defects on pattern deviation (PD) plots were determined. Agreement between two sets regarding the stage of visual field damage was assessed...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Mohamad-Reza Sedaghat, Farshad Askarizadeh, Mohsen Nematy, Foroozan Narooie-Noori, Javad Heravian, Tahereh Rakhshandadi, Sattar Rajabi
This study aimed to assess the possible relationship of body mass index (BMI) and blood pressure (BP) with corneal biomechanical parameters in healthy subjects. The study included 88 eyes of 88 healthy subjects aged 20-40 years. After a thorough medical history, a digital sphygmomanometer was used to measure the systolic blood pressure (SBP) and diastolic blood pressure (DBP). In addition, several hematological and biochemical parameters were determined to assess general health. Prior the ophthalmic examination, the body height and weight were measured; then, the BMI was calculated...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Rita Gama, Catarina Relha, Joana Gomes Costa, Nuno Eiro
The main purpose of this study was to assess the differences in the peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses between subjects with megalopapilla (MP) and those with large (physiological) cup discs (LCD) measured by spectral-domain optical coherence tomography. The secondary purpose was to determine whether pRNFL and GCIPL thicknesses increase with the optic nerve head (ONH) area. This cross-sectional study included 184 eyes (92 eyes with MP and 92 eyes with LCD)...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Alireza Dehghani, Heshmatollah Ghanbari, Abdolsamad Mahdizadeh, Mohsen Pourazizi
Patients with proliferative diabetic retinopathy (PDR) who are refractory to complete panretinal photocoagulation (PRP) have a high risk of severe vision loss. The aim of this study was to evaluate the effectiveness of single-dose intravitreal bevacizumab (IVB) after complete PRP in patients with refractory PDR. Patients with retinal neovascularization (NV) secondary to diabetes mellitus and refractory to complete PRP were enrolled in this study. All patients received a single dose of 1.25 mg IVB at 3 months after completing the PRP...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Hooshang Faghihi, Hanif Yahyapour, Raziyeh Mahmoudzadeh, Shahin Faghihi
The aim of this study was to compare the effect of intravitreal diclofenac, a non-steroidal anti-inflammatory drug (NSAID), with that of bevacizumab, a well-known anti-vascular endothelial growth factor (VEGF) drug, in the treatment of diabetic macular edema (DME). Diclofenac was chosen in this study because it has both features of NSAIDs and corticosteroids by inhibiting the cyclooxygenase (COX) and lipoxygenase pathways, respectively. In this non-randomized comparative interventional case series, 64 eyes from 32 patients with bilateral naïve DME were selected and every eye was randomly assigned to intravitreal injection of bevacizumab (IVB) or diclofenac (IVD)...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Mohammad Malekahmadi, Fereydoun Farrahi, Afshin Tajdini
Chalazion is a chronic, localized lipogranulomatous inflammation of the sebaceous glands of the lids. Chalazion occurs often secondary to blockage of the sebaceous gland ducts. Some studies have reported vitamin A deficiency as a risk factor for chalazion. In this study, we determined the serum levels of vitamin A in patients with chalazion. The study involved a total of 107 subjects (52 patients with chalazion and 55 control healthy subjects). The study was conducted at the Ophthalmology Clinics of Imam Khomeini Hospital, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran between September 2014 and February 2015...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Behzad Fallahi Motlagh, Ali Sadeghi
The aim of this study was to correlate macular thickness and visual field parameters in early glaucoma. A total of 104 eyes affected with early glaucoma were examined in a cross-sectional, prospective study. Visual field testing using both standard automated perimetry (SAP) and shortwave automated perimetry (SWAP) was performed. Global visual field parameters, including mean deviation (MD) and pattern standard deviation (PSD), were recorded and correlated with spectral domain optical coherence tomography (SD-OCT)-measured macular thickness and asymmetry...
2017: Medical Hypothesis, Discovery and Innovation in Ophthalmology
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