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Journal of Nephropathology

Hamid Nasri, Zahra Hasanpour, Mehdi Nematbakhsh, Ali Ahmadi, Mahmoud Rafieian-Kopaei
BACKGROUND: Recent retrospective observational studies suggest that high-potency statin therapy might increase the risk of acute kidney injury, however data on this subject is scares. OBJECTIVES: This study, was designed to investigate the renal tubular cell effect of different doses of atorvastatin to detect the possible aggravation of renal function or morphology of the kidney. MATERIALS AND METHODS: In this experimental study 24 male Wistar rats were designated into 4 equal groups and treated as follows...
July 2016: Journal of Nephropathology
Marwa M Shakweer, Maha Behairy, Nadia G Elhefnawy, Tamer W Elsaid
BACKGROUND: Forkhead box P3 (Foxp3) functions as a master regulator in the development and function of T-regulatory (Treg) cells. Recent studies have shown that autoimmune diseases including systemic lupus erythematosus (SLE) are associated with an imbalance with the Treg cells and T helper (Th) subtypes. OBJECTIVES: To evaluate immunohistochemical expression of Foxp3 positive Treg cells in lupus nephritis (LN) and analyze its association with clinicopathologic parameters...
July 2016: Journal of Nephropathology
Ali Monfared, Seyyede Zeinab Azimi, Ehsan Kazemnezhad
BACKGROUND: Statins improve prognosis in patients with coronary heart diseases by decreasing the incidence of vascular events. Excess prevalence of hyperhomocysteinemia, an independent risk factor of cardiovascular diseases, has been observed in stable renal transplant recipients (RTRs). OBJECTIVES: The objective of our study was to evaluate the association between atorvastatin administration and plasma total homocysteine (tHcy) levels in RTRs. PATIENTS AND METHODS: We performed a retrospective cross-sectional study in 148 cyclosporine A (CsA) treated stable RTRs...
July 2016: Journal of Nephropathology
Lionel Rostaing, Asma Allal, Arnaud Del Bello, Federico Sallusto, Laure Esposito, Nicolas Doumerc, Bénédicte Debiol, Audrey Delas, Xavier Game, Nassim Kamar
BACKGROUND: ABO-incompatible (ABOi) kidney-transplantation has very good long-term results, i.e. similar to those observed for living-kidney ABO-compatible transplantation. This is because patients are desensitized at pretransplant using apheresis and rituximab therapy, with tacrolimus-based immunosuppression. OBJECTIVES: To assess the efficacy of a single, pretransplant (Day -1), specific immunoadsorption session using Glycosorb® columns (anti-A or anti-B; Glycorex Sweden) to treat large volumes of plasma (up to 18 L)...
July 2016: Journal of Nephropathology
Bahar Bastani
No abstract text is available yet for this article.
July 2016: Journal of Nephropathology
Hernán Trimarchi, Tatiana Rengel, José Andrews, Matías Paulero, Alejandro Iotti, Agustina Forastiero, Fernando Lombi, Vanesa Pomeranz, Mariano Forrester, Romina Iriarte, Iris Agorio
BACKGROUND: In transplantation immunosuppression enhances the appearance of opportunist infections. An ideal balance between the prevention of rejection, the lowest risk of infections and the highest rates of graft survival is a continuous challenge. Lower doses of immunosuppression may diminish the risk of infections, metabolic and hemodynamic complications or even of malignancy, but may expose patients to episodes of acute rejection. New drugs are being developed to improve graft survival at the lowest risk of side effects...
April 2016: Journal of Nephropathology
Youshay Humayun, Kenneth C Ball, Jack R Lewin, Anna A Lerant, Tibor Fülöp
BACKGROUND: Obesity is a major world-wide epidemic which has led to a surge of various weight loss-inducing medical or surgical treatments. Orlistat is a gastrointestinal lipase inhibitor used as an adjunct treatment of obesity and type 2 diabetes mellitus to induce clinically significant weight loss via fat malabsorption. CASE PRESENTATION: We describe a case of a 76-year-old female with past medical history of chronic kidney disease (baseline serum creatinine was 1...
April 2016: Journal of Nephropathology
Chihiro Iwasaki, Takahito Moriyama, Kayu Tanaka, Takashi Takei, Kosaku Nitta
BACKGROUND: The relationship between hematuria and histological lesions, the effect of hematuria on response to steroid therapy, and the outcome in patients with immunoglobulin A nephropathy (IgAN) remain undetermined. OBJECTIVES: The aim of this study was to clarify the effect of hematuria on histological findings, response to steroid treatment, and the outcome in IgA nephropathy. PATIENTS AND METHODS: Seventy-five patients with IgAN and proteinuria > 1 g/day and treated with prednisolone were divided into two groups: those with low (≤20/high-power field [HPF]) urinary red blood cell (U-RBC) counts (L-RBC group, n=55) and those with high (>20/HPF) U-RBC counts (H-RBC group, n=20)...
April 2016: Journal of Nephropathology
Dashurie Neziri, Sahra Pajenda, Rebecca Amuge, Aysegul Ilhan, Marlene Wewalka, Gregor Hörmann, Christian Zauner, Ludwig Wagner
BACKGROUND: Acute kidney injury (AKI) is a life threatening condition. Despite intensive care treatment the occurrence cannot be predicted as very little indicators exist for direct measurement when tubular epithelial cell injury takes place. We therefore searched for novel peptide indicators expressed at intracellular level at the proximal kidney tubule for its appearance in urine samples. OBJECTIVES: Establishing a test for urinary C20orf116 protein measurement...
April 2016: Journal of Nephropathology
Sabiha Anis
No abstract text is available yet for this article.
April 2016: Journal of Nephropathology
Mohammad Kazem Fallahzadeh, Neeraj Singh
No abstract text is available yet for this article.
January 2016: Journal of Nephropathology
Shervin Assari
BACKGROUND: Kidney failure and associated mortality is one of the major components of racial disparities in the United States. OBJECTIVES: The current study aimed to investigate the role of distal (socioeconomic status, SES), intermediate (chronic medical diseases), and proximal (health behaviors) factors that may explain Black-White disparities in mortality due to renal diseases. PATIENTS AND METHODS: This is a nationally representative prospective cohort with 25 years of follow up...
January 2016: Journal of Nephropathology
Babak Baharvand-Ahmadi, Mahmoud Bahmani, Pegah Tajeddini, Nasrollah Naghdi, Mahmoud Rafieian-Kopaei
BACKGROUND: Diabetes is the greatest public health problem and is considered as the silent epidemic of the 21st century. In Iran, there are approximately 1.5 million diabetic patients. Before the discovery of insulin, medicinal plants were widely used for the treatment of diabetes in Iran. OBJECTIVES: This study aimed to determine the indigenous plants used for the treatment of diabetes in Shiraz, southwest of Iran. MATERIALS AND METHODS: Semi-structured direct interviews were conducted with 25 herbalists to identify medicinal plants used to treat diabetes...
January 2016: Journal of Nephropathology
Narges-Sadat Zahed, Maryam Ghassami, Hajar Nikbakht
BACKGROUND: The most leading cause of death in end-stage renal disease (ESRD) patients are cardiovascular disease and inflammatory markers are related to coronary events. CO-Q10 (coenzyme Q10) is a protective supplement from free radical oxidative damage. In addition, hyperhomocysteinemia is an independent coronary artery disease (CAD) risk factor. OBJECTIVES: Due to increasing oxidative stress in dialysis patients, and the effect of CO-Q10 in decrease oxidative stress, in this work, we assessed the effect of CO-Q10 on C-reactive protein (CRP) level as an inflammatory marker and homocysteine in dialysis patients...
January 2016: Journal of Nephropathology
Nicole Nesselhauf, Jaclyn Strutt, Bahar Bastani
BACKGROUND: BK virus reactivation is a significant complication following renal transplantation that can result in graft failure. Reduction of immunosuppression and substitution of leflunomide for mycophenolate mofetil (MMF) has been used to treat this entity. OBJECTIVES: To evaluate the use of leflunomide in BK viremia (BKV) and biopsy proven BK nephropathy (BKN) in kidney and kidney-pancreas transplant recipients. PATIENTS AND METHODS: We retrospectively reviewed 28 kidney and kidney-pancreas transplant recipients who had received leflunomide for BKV from January 2006 to November 2012...
January 2016: Journal of Nephropathology
Mohammad Reza Jafari-Nakhjavani, Sima Abedi-Azar, Babak Nejati
BACKGROUND: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by activation of T and polyclonal B lymphocytes. IL-18 was originally identified as a factor which enhances IFN-γ production and is a potent inducer of the inflammatory mediators by T cells, causing severe inflammatory disorders in SLE. OBJECTIVES: This study aimed to evaluate the association of plasma interlukine-18 (IL-18) concentration and severity of lupus nephritis (LN) and disease activity in SLE patients...
January 2016: Journal of Nephropathology
Hamza Naciri Bennani, Zhyiar Abdulrahman, Asma Allal, Federico Sallusto, Antoine Delarche, Xavier Game, Laure Esposito, Nicolas Doumerc, Bénédicte Debiol, Nassim Kamar, Lionel Rostaing
BACKGROUND: Living-kidney transplantation is increasing because of the scarcity of kidneys from deceased donors and the increasing numbers of patients on waiting lists for a kidney transplant. Living-kidney transplantation is now associated with increased long-term patient- and allograft-survival rates. OBJECTIVES: The purpose of this retrospective study was to identify, in a cohort of 44 ABO-incompatible (ABOi) live-kidney transplant patients, the main complications that occurred within 6 months post-transplantation, and to compare these findings with those from 44 matched ABO-compatible (ABOc) live-kidney transplant patients who were also from our center...
January 2016: Journal of Nephropathology
Hamid Nasri, Mahmoud Rafieian-Kopaei
CONTEXT: World kidney day is a yearly global alertness and education ceremony, held on the second Thursday in March. EVIDENCE ACQUISITION: Directory of open access journals (DOAJ), EMBASE, Google Scholar, PubMed, EBSCO, and Web of Science have been searched. RESULTS: Once again we reached to March 14, the world kidney day of 2016. This is the 10th anniversary of world kidney day, a program of the International Society of Nephrology (ISN) and the International Federation of Kidney Foundations (IFKF)...
January 2016: Journal of Nephropathology
Haydarali Esmaili, Elmira Mostafidi, Bahareh Mehramuz, Mohammadreza Ardalan, Mohammadali Mohajel-Shoja
CONTEXT: Hemophagocytic syndrome (HPS) is mainly characterized by massive infiltration of bone marrow by activated macrophages and often presents with pancytopenia. Thrombotic microangiopathy (TMA) is also present with thrombocytopenia and renal involvement. Both conditions could coexist with each other and complicate the condition. EVIDENCE ACQUISITION: Directory of Open Access Journals (DOAJ), EMBASE, Google Scholar, PubMed, EBSCO, and Web of Science with keywords relevant to; Hemophagocytic syndrome, macrophage activation syndrome, interferon-gamma and thrombotic microangiopathy, have been searched...
January 2016: Journal of Nephropathology
Thomas Jouve, Lionel Rostaing, Paolo Malvezzi
CONTEXT: BK virus (BKV) viremia and BKV-associated nephropathy (BKVAN) have become a serious nuisance to kidney transplant (KT) patients since the mid-nineties, when the incidence of this disease has increased significantly. EVIDENCE ACQUISITION: Directory of open access journals (DOAJ), EMBASE, Google Scholar, PubMed, EBSCO, and Web of Science have been searched. RESULTS: Many hypothesis have been made as to why this phenomenon has developed; it is of general opinion that a more potent immunosuppression is at the core of the problem...
January 2016: Journal of Nephropathology
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