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Biosensors

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https://www.readbyqxmd.com/read/28212271/carbon-nanotubes-as-an-effective-opportunity-for-cancer-diagnosis-and-treatment
#1
REVIEW
Alessandro Sanginario, Beatrice Miccoli, Danilo Demarchi
Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation...
February 15, 2017: Biosensors
https://www.readbyqxmd.com/read/28117762/composite-hydrogels-with-engineered-microdomains-for-optical-glucose-sensing-at-low-oxygen-conditions
#2
Lindsey R Bornhoeft, Aniket Biswas, Michael J McShane
There is a growing need for advanced tools that enable frequent monitoring of biomarkers for precision medicine. In this work, we present a composite hydrogel-based system providing real-time optical bioanalyte monitoring. The responsive material, alginate-in-alginate (AnA), is comprised of an alginate hydrogel with embedded bioactive, nanofilm-coated phosphorescent microdomains; palladium tetracarboxyphenylporphyrin serves as an optical indicator, glucose oxidase as a model enzyme, and layer-by-layer deposited polyelectrolyte multilayers (PEMs) as the diffusion barrier...
January 22, 2017: Biosensors
https://www.readbyqxmd.com/read/28085088/surface-enhanced-raman-scattering-based-immunoassay-technologies-for-detection-of-disease-biomarkers
#3
REVIEW
Joseph Smolsky, Sukhwinder Kaur, Chihiro Hayashi, Surinder K Batra, Alexey V Krasnoslobodtsev
Detection of biomarkers is of vital importance in disease detection, management, and monitoring of therapeutic efficacy. Extensive efforts have been devoted to the development of novel diagnostic methods that detect and quantify biomarkers with higher sensitivity and reliability, contributing to better disease diagnosis and prognosis. When it comes to such devastating diseases as cancer, these novel powerful methods allow for disease staging as well as detection of cancer at very early stages. Over the past decade, there have been some advances in the development of platforms for biomarker detection of diseases...
January 12, 2017: Biosensors
https://www.readbyqxmd.com/read/28075378/acknowledgement-to-reviewers-of-biosensors-in-2016
#4
EDITORIAL
Biosensors Editorial Office
The editors of Biosensors would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...].
January 10, 2017: Biosensors
https://www.readbyqxmd.com/read/28067772/alternating-current-dielectrophoresis-collection-and-chaining-of-phytoplankton-on-chip-comparison-of-individual-species-and-artificial-communities
#5
COMPARATIVE STUDY
Coralie Siebman, Orlin D Velev, Vera I Slaveykova
The capability of alternating current (AC) dielectrophoresis (DEP) for on-chip capture and chaining of the three species representative of freshwater phytoplankton was evaluated. The effects of the AC field intensity, frequency and duration on the chaining efficiency and chain lengths of green alga Chlamydomonas reinhardtii, cyanobacterium Synechocystis sp. and diatom Cyclotella meneghiniana were characterized systematically. C. reinhardtii showed an increase of the chaining efficiency from 100 Hz to 500 kHz at all field intensities; C...
January 5, 2017: Biosensors
https://www.readbyqxmd.com/read/28054983/aptamer-sensors
#6
EDITORIAL
Giovanna Marrazza
In the last years, great progress has been accomplished in the development of aptamer sensors with different transducers. In order to improve the sensitivity of these biosensors, several methodologies have been employed. In this Special Issue, the state of art and the future trends in the field of aptamer sensors have been explored.
January 4, 2017: Biosensors
https://www.readbyqxmd.com/read/28054956/a-strategy-to-establish-a-quality-assurance-quality-control-plan-for-the-application-of-biosensors-for-the-detection-of-e-coli-in-water
#7
Nikou Hesari, Nursel Kıratlı Yılmazçoban, Mohamad Elzein, Absar Alum, Morteza Abbaszadegan
Rapid bacterial detection using biosensors is a novel approach for microbiological testing applications. Validation of such methods is an obstacle in the adoption of new bio-sensing technologies for water testing. Therefore, establishing a quality assurance and quality control (QA/QC) plan is essential to demonstrate accuracy and reliability of the biosensor method for the detection of E. coli in drinking water samples. In this study, different reagents and assay conditions including temperatures, holding time, E...
January 3, 2017: Biosensors
https://www.readbyqxmd.com/read/28045439/design-and-development-of-non-contact-bio-potential-electrodes-for-pervasive-health-monitoring-applications
#8
Anthony J Portelli, Slawomir J Nasuto
For the advent of pervasive bio-potential monitoring, it will be necessary to utilize a combination of cheap, quick to apply, low-noise electrodes and compact electronics with wireless technologies. Once available, all electrical activity resulting from the processes of the human body could be actively and constantly monitored without the need for cumbersome application and maintenance. This could significantly improve the early diagnosis of a range of different conditions in high-risk individuals, opening the possibility for new treatments and interventions as conditions develop...
January 1, 2017: Biosensors
https://www.readbyqxmd.com/read/28025564/versatile-flexible-graphene-multielectrode-arrays
#9
Dmitry Kireev, Silke Seyock, Mathis Ernst, Vanessa Maybeck, Bernhard Wolfrum, Andreas Offenhäusser
Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells...
December 23, 2016: Biosensors
https://www.readbyqxmd.com/read/27999382/rapid-detection-of-bacillus-anthracis-spores-using-immunomagnetic-separation-and-amperometry
#10
David F Waller, Brian E Hew, Charlie Holdaway, Michael Jen, Gabriel D Peckham
Portable detection and quantitation methods for Bacillus anthracis (anthrax) spores in pure culture or in environmental samples are lacking. Here, an amperometric immunoassay has been developed utilizing immunomagnetic separation to capture the spores and remove potential interferents from test samples followed by amperometric measurement on a field-portable instrument. Antibody-conjugated magnetic beads and antibody-conjugated glucose oxidase were used in a sandwich format for the capture and detection of target spores...
December 20, 2016: Biosensors
https://www.readbyqxmd.com/read/27999300/a-novel-mos-nanowire-gas-sensor-device-s3-and-gc-ms-based-approach-for-the-characterization-of-grated-parmigiano-reggiano-cheese
#11
Veronica Sberveglieri, Manohar Prasad Bhandari, Estefanía Núñez Carmona, Giulia Betto, Giorgio Sberveglieri
To determine the originality of a typical Italian Parmigiano Reggiano cheese, it is crucial to define and characterize its quality, ripening period, and geographical origin. Different analytical techniques have been applied aimed at studying the organoleptic and characteristic volatile organic compounds (VOCs) profile of this cheese. However, most of the classical methods are time consuming and costly. The aim of this work was to illustrate a new simple, portable, fast, reliable, non-destructive, and economic sensor device S3 based on an array of six metal oxide semiconductor nanowire gas sensors to assess and discriminate the quality ranking of grated Parmigiano Reggiano cheese samples and to identify the VOC biomarkers using a headspace SPME-GC-MS...
December 16, 2016: Biosensors
https://www.readbyqxmd.com/read/27918419/a-theoretical-study-of-love-wave-sensors-based-on-zno-glass-layered-structures-for-application-to-liquid-environments
#12
Cinzia Caliendo, Muhammad Hamidullah
The propagation of surface acoustic Love modes along ZnO/glass-based structures was modeled and analysed with the goal of designing a sensor able to detect changes in the environmental parameters, such as liquid viscosity changes and minute amounts of mass supported in the viscous liquid medium. Love mode propagation was modeled by numerically solving the system of coupled electro-mechanical field equations and Navier-Stokes equations. The phase and group velocities and the attenuation of the acoustic wave propagating along the 30° tilted c-axis ZnO/glass structure contacting a viscous non-conductive liquid were calculated for different ZnO guiding layer thicknesses, added mass thicknesses, and liquid viscosity and density...
December 2, 2016: Biosensors
https://www.readbyqxmd.com/read/27916817/real-time-classification-of-patients-with-balance-disorders-vs-normal-subjects-using-a-low-cost-small-wireless-wearable-gait-sensor
#13
Bhargava Teja Nukala, Taro Nakano, Amanda Rodriguez, Jerry Tsay, Jerry Lopez, Tam Q Nguyen, Steven Zupancic, Donald Y C Lie
Gait analysis using wearable wireless sensors can be an economical, convenient and effective way to provide diagnostic and clinical information for various health-related issues. In this work, our custom designed low-cost wireless gait analysis sensor that contains a basic inertial measurement unit (IMU) was used to collect the gait data for four patients diagnosed with balance disorders and additionally three normal subjects, each performing the Dynamic Gait Index (DGI) tests while wearing the custom wireless gait analysis sensor (WGAS)...
November 29, 2016: Biosensors
https://www.readbyqxmd.com/read/27916791/different-phases-of-breast-cancer-cells-raman-study-of-immortalized-transformed-and-invasive-cells
#14
Deepika Chaturvedi, Sai A Balaji, Vinay Kumar Bn, Freek Ariese, Siva Umapathy, Annapoorni Rangarajan
Breast cancer is the most prevalent cause of cancer-associated death in women the world over, but if detected early it can be treated successfully. Therefore, it is important to diagnose this disease at an early stage and to understand the biochemical changes associated with cellular transformation and cancer progression. Deregulated lipid metabolism has been shown to contribute to cell transformation as well as cancer progression. In this study, we monitored the biomolecular changes associated with the transformation of a normal cell into an invasive cell associated with breast cancer using Raman microspectroscopy...
November 28, 2016: Biosensors
https://www.readbyqxmd.com/read/27879639/disposable-amperometric-immunosensor-for-the-determination-of-human-p53-protein-in-cell-lysates-using-magnetic-micro-carriers
#15
María Pedrero, F Javier Manuel de Villena, Cristina Muñoz-San Martín, Susana Campuzano, María Garranzo-Asensio, Rodrigo Barderas, José M Pingarrón
An amperometric magnetoimmunosensor for the determination of human p53 protein is described in this work using a sandwich configuration involving the covalent immobilization of a specific capture antibody onto activated carboxylic-modified magnetic beads (HOOC-MBs) and incubation of the modified MBs with a mixture of the target protein and horseradish peroxidase-labeled antibody (HRP-anti-p53). The resulting modified MBs are captured by a magnet placed under the surface of a disposable carbon screen-printed electrode (SPCE) and the amperometric responses are measured at -0...
November 21, 2016: Biosensors
https://www.readbyqxmd.com/read/27827852/terma-framework-for-biomedical-signal-analysis-an-economic-inspired-approach
#16
Mohamed Elgendi
Biomedical signals contain features that represent physiological events, and each of these events has peaks. The analysis of biomedical signals for monitoring or diagnosing diseases requires the detection of these peaks, making event detection a crucial step in biomedical signal processing. Many researchers have difficulty detecting these peaks to investigate, interpret and analyze their corresponding events. To date, there is no generic framework that captures these events in a robust, efficient and consistent manner...
November 2, 2016: Biosensors
https://www.readbyqxmd.com/read/27792176/wrist-pulse-rate-monitor-using-self-injection-locked-radar-technology
#17
REVIEW
Fu-Kang Wang, Mu-Cyun Tang, Sheng-Chao Su, Tzyy-Sheng Horng
To achieve sensitivity, comfort, and durability in vital sign monitoring, this study explores the use of radar technologies in wearable devices. The study first detected the respiratory rates and heart rates of a subject at a one-meter distance using a self-injection-locked (SIL) radar and a conventional continuous-wave (CW) radar to compare the sensitivity versus power consumption between the two radars. Then, a pulse rate monitor was constructed based on a bistatic SIL radar architecture. This monitor uses an active antenna that is composed of a SIL oscillator (SILO) and a patch antenna...
October 26, 2016: Biosensors
https://www.readbyqxmd.com/read/27754393/biofouling-resistant-impedimetric-sensor-for-array-high-resolution-extracellular-potassium-monitoring-in-the-brain
#18
Ruben Machado, Nima Soltani, Suzie Dufour, Muhammad Tariqus Salam, Peter L Carlen, Roman Genov, Michael Thompson
Extracellular potassium concentration, [K⁺]o, plays a fundamental role in the physiological functions of the brain. Studies investigating changes in [K⁺]o have predominantly relied upon glass capillary electrodes with K⁺-sensitive solution gradients for their measurements. However, such electrodes are unsuitable for taking spatio-temporal measurements and are limited by the surface area of their tips. We illustrate seizures invoked chemically and in optogenetically modified mice using blue light exposure while impedimetrically measuring the response...
October 13, 2016: Biosensors
https://www.readbyqxmd.com/read/27727183/kinetics-of-antibody-binding-to-membranes-of-living-bacteria-measured-by-a-photonic-crystal-based-biosensor
#19
Ekaterina Rostova, Carine Ben Adiba, Giovanni Dietler, Sergey K Sekatskii
Optical biosensors based on photonic crystal surface waves (PC SWs) offer a possibility to study binding interactions with living cells, overcoming the limitation of rather small evanescent field penetration depth into a sample medium that is characteristic for typical optical biosensors. Besides this, simultaneous excitation of s- and p-polarized surface waves with different penetration depths is realized here, permitting unambiguous separation of surface and volume contributions to the measured signal. PC-based biosensors do not require a bulk signal correction, compared to widely used surface plasmon resonance-based devices...
October 11, 2016: Biosensors
https://www.readbyqxmd.com/read/27690119/biosensing-with-paper-based-miniaturized-printed-electrodes-a-modern-trend
#20
REVIEW
Célia M Silveira, Tiago Monteiro, Maria Gabriela Almeida
From the bench-mark work on microfluidics from the Whitesides's group in 2007, paper technology has experienced significant growth, particularly regarding applications in biomedical research and clinical diagnostics. Besides the structural properties supporting microfluidics, other advantageous features of paper materials, including their versatility, disposability and low cost, show off the great potential for the development of advanced and eco-friendly analytical tools. Consequently, paper was quickly employed in the field of electrochemical sensors, being an ideal material for producing custom, tailored and miniaturized devices...
September 28, 2016: Biosensors
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