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Biosensors

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https://www.readbyqxmd.com/read/29783669/limits-to-the-evaluation-of-the-accuracy-of-continuous-glucose-monitoring-systems-by-clinical-trials
#1
Patrick Schrangl, Florian Reiterer, Lutz Heinemann, Guido Freckmann, Luigi Del Re
Systems for continuous glucose monitoring (CGM) are evolving quickly, and the data obtained are expected to become the basis for clinical decisions for many patients with diabetes in the near future. However, this requires that their analytical accuracy is sufficient. This accuracy is usually determined with clinical studies by comparing the data obtained by the given CGM system with blood glucose (BG) point measurements made with a so-called reference method. The latter is assumed to indicate the correct value of the target quantity...
May 18, 2018: Biosensors
https://www.readbyqxmd.com/read/29772654/consistency-of-continuous-ambulatory-interstitial-glucose-monitoring-sensors
#2
Pei T Wu, David E Segovia, Cathy C Lee, Kim-Lien Nguyen
AIMS: The abdominal region is the most common location for continuous glucose monitor (CGM) sensor insertion. However, a paucity of post-marketing data is available to demonstrate intra-individual consistency of CGM readings at different abdominal insertion sites. METHODS: Healthy adults (fasting glucose (FG) < 5.5 mmol/L; BMI < 30 kg/m²) were recruited and a CGM sensor was placed on each side of the abdomen. Postprandial and continuous 48-h interstitial glucose levels were analyzed...
May 16, 2018: Biosensors
https://www.readbyqxmd.com/read/29762509/breathing-pattern-interpretation-as-an-alternative-and-effective-voice-communication-solution
#3
Yasmin Elsahar, Kaddour Bouazza-Marouf, David Kerr, Atul Gaur, Vipul Kaushik, Sijung Hu
Augmentative and alternative communication (AAC) systems tend to rely on the interpretation of purposeful gestures for interaction. Existing AAC methods could be cumbersome and limit the solutions in terms of versatility. The study aims to interpret breathing patterns (BPs) to converse with the outside world by means of a unidirectional microphone and researches breathing-pattern interpretation (BPI) to encode messages in an interactive manner with minimal training. We present BP processing work with (1) output synthesized machine-spoken words (SMSW) along with single-channel Weiner filtering (WF) for signal de-noising, and (2) k -nearest neighbor ( k-NN ) classification of BPs associated with embedded dynamic time warping (DTW)...
May 15, 2018: Biosensors
https://www.readbyqxmd.com/read/29762479/development-of-a-polyphenol-oxidase-biosensor-from-jenipapo-fruit-extract-genipa-americana-l-and-determination-of-phenolic-compounds-in-textile-industrial-effluents
#4
Rafael Souza Antunes, Denes Ferraz, Luane Ferreira Garcia, Douglas Vieira Thomaz, Rafael Luque, Germán Sanz Lobón, Eric de Souza Gil, Flávio Marques Lopes
In this work, an innovative polyphenol oxidase biosensor was developed from Jenipapo ( Genipa americana L.) fruit and used to assess phenolic compounds in industrial effluent samples obtained from a textile industry located in Jaraguá-GO, Brasil. The biosensor was prepared and optimized according to: the proportion of crude vegetal extract, pH and overall voltammetric parameters for differential pulse voltammetry. The calibration curve presented a linear interval from 10 to 310 µM (r² = 0.9982) and a limit of detection of 7 µM...
May 15, 2018: Biosensors
https://www.readbyqxmd.com/read/29751641/in-vitro-and-in-vivo-sers-biosensing-for-disease-diagnosis
#5
REVIEW
T Joshua Moore, Amber S Moody, Taylor D Payne, Grace M Sarabia, Alyssa R Daniel, Bhavya Sharma
For many disease states, positive outcomes are directly linked to early diagnosis, where therapeutic intervention would be most effective. Recently, trends in disease diagnosis have focused on the development of label-free sensing techniques that are sensitive to low analyte concentrations found in the physiological environment. Surface-enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy that allows for label-free, highly sensitive, and selective detection of analytes through the amplification of localized electric fields on the surface of a plasmonic material when excited with monochromatic light...
May 11, 2018: Biosensors
https://www.readbyqxmd.com/read/29738428/droplet-velocity-measurement-based-on-dielectric-layer-thickness-variation-using-digital-microfluidic-devices
#6
Siti Noor Idora Syafinaz Zulkepli, Nor Hisham Hamid, Vineeta Shukla
In recent years, the number of interdisciplinary research works related to the development of miniaturized systems with integrated chemical and biological analyses is increasing. Digital microfluidic biochips (DMFBs) are one kind of miniaturized systems designed for conducting inexpensive, fast, convenient and reliable biochemical assay procedures focusing on basic scientific research and medical diagnostics. The role of a dielectric layer in the digital microfluidic biochips is prominent as it helps in actuating microliter droplets based on the electrowetting-on-dielectric (EWOD) technique...
May 8, 2018: Biosensors
https://www.readbyqxmd.com/read/29701726/sensor-access-to-the-cellular-microenvironment-using-the-sensing-cell-culture-flask
#7
Jochen Kieninger, Yaara Tamari, Barbara Enderle, Gerhard Jobst, Joe A Sandvik, Erik O Pettersen, Gerald A Urban
The Sensing Cell Culture Flask (SCCF) is a cell culture monitoring system accessing the cellular microenvironment in 2D cell culture using electrochemical microsensors. The system is based on microfabricated sensor chips embedded in standard cell culture flasks. Ideally, the sensor chips could be equipped with any electrochemical sensor. Its transparency allows optical inspection of the cells during measurement. The surface of the sensor chip is in-plane with the flask surface allowing undisturbed cell growth on the sensor chip...
April 26, 2018: Biosensors
https://www.readbyqxmd.com/read/29693557/continuous-glucose-monitoring-in-resource-constrained-settings-for-hypoglycaemia-detection-looking-at-the-problem-from-the-other-side-of-the-coin
#8
Rubao Bila, Rosauro Varo, Lola Madrid, Antonio Sitoe, Quique Bassat
The appearance, over a decade ago, of continuous glucose monitoring (CGM) devices has triggered a patient-centred revolution in the control and management of diabetes mellitus and other metabolic conditions, improving the patient&rsquo;s glycaemic control and quality of life. Such devices, the use of which remains typically restricted to high-income countries on account of their elevated costs, at present show very limited implantation in resource-constrained settings, where many other urgent health priorities beyond diabetes prevention and management still need to be resolved...
April 25, 2018: Biosensors
https://www.readbyqxmd.com/read/29695046/laser-scribed-graphene-biosensor-for-detection-of-biogenic-amines-in-food-samples-using-locally-sourced-materials
#9
Diana C Vanegas, Laksmi Patiño, Connie Mendez, Daniela Alves de Oliveira, Alba M Torres, Carmen L Gomes, Eric S McLamore
In foods, high levels of biogenic amines (BA) are the result of microbial metabolism that could be affected by temperatures and storage conditions. Thus, the level of BA is commonly used as an indicator of food safety and quality. This manuscript outlines the development of laser scribed graphene electrodes, with locally sourced materials, for reagent-free food safety biosensing. To fabricate the biosensors, the graphene surface was functionalized with copper microparticles and diamine oxidase, purchased from a local supermarket; and then compared to biosensors fabricated with analytical grade materials...
April 24, 2018: Biosensors
https://www.readbyqxmd.com/read/29652815/olfactory-dysfunction-as-a-global-biomarker-for-sniffing-out-alzheimer-s-disease-a-meta-analysis
#10
Alisha M Kotecha, Angelo D C Corrêa, Kim M Fisher, Jo V Rushworth
Cases of Alzheimer's disease (AD) are rising exponentially due to increasing global life expectancy. There are approximately 50 million sufferers worldwide, with prevalence rising most rapidly in low-income countries such as Africa and Asia. There is currently no definite diagnosis of AD until after death, thus an early biomarker for AD is urgently required in order to administer timelier and more effective interventions. Olfactory dysfunction (problems with the sense of smell) is one of the earliest, preclinical symptoms observed in AD...
April 13, 2018: Biosensors
https://www.readbyqxmd.com/read/29641511/s-layer-protein-based-biosensors
#11
Bernhard Schuster
The present paper highlights the application of bacterial surface (S-) layer proteins as versatile components for the fabrication of biosensors. One technologically relevant feature of S-layer proteins is their ability to self-assemble on many surfaces and interfaces to form a crystalline two-dimensional (2D) protein lattice. The S-layer lattice on the surface of a biosensor becomes part of the interface architecture linking the bioreceptor to the transducer interface, which may cause signal amplification. The S-layer lattice as ultrathin, highly porous structure with functional groups in a well-defined special distribution and orientation and an overall anti-fouling characteristics can significantly raise the limit in terms of variety and the ease of bioreceptor immobilization, compactness of bioreceptor molecule arrangement, sensitivity, specificity, and detection limit for many types of biosensors...
April 11, 2018: Biosensors
https://www.readbyqxmd.com/read/29642606/metabolism-driven-high-throughput-cancer-identification-with-glut5-specific-molecular-probes
#12
Srinivas Kannan, Vagarshak V Begoyan, Joseph R Fedie, Shuai Xia, Łukasz J Weseliński, Marina Tanasova, Smitha Rao
Point-of-care applications rely on biomedical sensors to enable rapid detection with high sensitivity and selectivity. Despite advances in sensor development, there are challenges in cancer diagnostics. Detection of biomarkers, cell receptors, circulating tumor cells, gene identification, and fluorescent tagging are time-consuming due to the sample preparation and response time involved. Here, we present a novel approach to target the enhanced metabolism in breast cancers for rapid detection using fluorescent imaging...
April 10, 2018: Biosensors
https://www.readbyqxmd.com/read/29642494/raman-spectroscopic-and-microscopic-analysis-for-monitoring-renal-osteodystrophy-signatures
#13
John D Ciubuc, Marian Manciu, Avudaiappan Maran, Michael J Yaszemski, Emma M Sundin, Kevin E Bennet, Felicia S Manciu
Defining the pathogenesis of renal osteodystrophy (ROD) and its treatment efficacy are difficult, since many factors potentially affect bone quality. In this study, confocal Raman microscopy and parallel statistical analysis were used to identify differences in bone composition between healthy and ROD bone tissues through direct visualization of three main compositional parametric ratios, namely, calcium content, mineral-to-matrix, and carbonate-to-matrix. Besides the substantially lower values found in ROD specimens for these representative ratios, an obvious accumulation of phenylalanine is Raman spectroscopically observed for the first time in ROD samples and reported here...
April 8, 2018: Biosensors
https://www.readbyqxmd.com/read/29621176/functionalized-thick-film-impedance-sensors-for-use-in-in-vitro-cell-culture
#14
Heike Bartsch, Martin Baca, Uta Fernekorn, Jens Müller, Andreas Schober, Hartmut Witte
Multi-electrode arrays find application in electrophysiological recordings. The quality of the captured signals depends on the interfacial contact between electrogenic cells and the electronic system. Therefore, it requires reliable low-impedance electrodes. Low-temperature cofired ceramic technology offers a suitable platform for rapid prototyping of biological reactors and can provide both stable fluid supply and integrated bio-hardware interfaces for recordings in electrogenic cell cultures. The 3D assembly of thick film gold electrodes in in vitro bio-reactors has been demonstrated for neuronal recordings...
April 5, 2018: Biosensors
https://www.readbyqxmd.com/read/29614829/the-use-of-a-polyphenoloxidase-biosensor-obtained-from-the-fruit-of-jurubeba-solanum-paniculatum-l-in-the-determination-of-paracetamol-and-other-phenolic-drugs
#15
Rafael Souza Antunes, Luane Ferreira Garcia, Vernon Sydwill Somerset, Eric de Souza Gil, Flavio Marques Lopes
The vegetable kingdom is a wide source of a diverse variety of enzymes with broad biotechnological applications. Among the main classes of plant enzymes, the polyphenol oxidases, which convert phenolic compounds to the related quinones, have been successfully used for biosensor development. The oxidation products from such enzymes can be electrochemically reduced, and the sensing is easily achieved by amperometric transducers. In this work, the polyphenoloxidases were extracted from jurubeba ( Solanum paniculatum L...
April 2, 2018: Biosensors
https://www.readbyqxmd.com/read/29614784/sensors-based-on-bio-and-biomimetic-receptors-in-medical-diagnostic-environment-and-food-analysis
#16
REVIEW
Alisa N Kozitsina, Tatiana S Svalova, Natalia N Malysheva, Andrei V Okhokhonin, Marina B Vidrevich, Khiena Z Brainina
Analytical chemistry is now developing mainly in two areas: automation and the creation of complexes that allow, on the one hand, for simultaneously analyzing a large number of samples without the participation of an operator, and on the other, the development of portable miniature devices for personalized medicine and the monitoring of a human habitat. The sensor devices, the great majority of which are biosensors and chemical sensors, perform the role of the latter. That last line is considered in the proposed review...
April 1, 2018: Biosensors
https://www.readbyqxmd.com/read/29601504/label-free-electrochemical-immunoassay-for-c-reactive-protein
#17
Madasamy Thangamuthu, Christian Santschi, Olivier J F Martin
C-reactive protein (CRP) is one of the most expressed proteins in blood during acute phase inflammation, and its minute level increase has also been recognized for the clinical diagnosis of cardio vascular diseases. Unfortunately, the available commercial immunoassays are labour intensive, require large sample volumes, and have practical limitations, such as low stability and high production costs. Hence, we have developed a simple, cost effective, and label-free electrochemical immunoassay for the measurement of CRP in a drop of serum sample using an immunosensor strip made up of a screen printed carbon electrode (SPE) modified with anti-CRP functionalized gold nanoparticles (AuNPs)...
March 30, 2018: Biosensors
https://www.readbyqxmd.com/read/29596396/smart-garment-fabrics-to-enable-non-contact-opto-physiological-monitoring
#18
Dmitry Iakovlev, Sijung Hu, Harnani Hassan, Vincent Dwyer, Roya Ashayer-Soltani, Chris Hunt, Jinsong Shen
Imaging photoplethysmography (iPPG) is an emerging technology used to assess microcirculation and cardiovascular signs by collecting backscattered light from illuminated tissue using optical imaging sensors. The aim of this study was to study how effective smart garment fabrics could be capturing physiological signs in a non-contact mode. The present work demonstrates a feasible approach of, instead of using conventional high-power illumination sources, integrating a grid of surface-mounted light emitting diodes (LEDs) into cotton fabric to spotlight the region of interest (ROI)...
March 29, 2018: Biosensors
https://www.readbyqxmd.com/read/29584662/development-of-a-%C3%AE-lactoglobulin-sensor-based-on-spr-for-milk-allergens-detection
#19
Jon Ashley, Roberta D'Aurelio, Monika Piekarska, Jeff Temblay, Mike Pleasants, Linda Trinh, Thomas L Rodgers, Ibtisam E Tothill
A sensitive and label-free surface plasmon resonance (SPR) based sensor was developed in this work for the detection of milk allergens. β-lactoglobulin (BLG) protein was used as the biomarker for cow milk detection. This is to be used directly in final rinse samples of cleaning in-place (CIP) systems of food manufacturers. The affinity assay was optimised and characterised before a standard curve was performed in pure buffer conditions, giving a detection limit of 0.164 µg mL-1 as a direct binding assay. The detection limit can be further enhanced through the use of a sandwich assay and amplification with nanomaterials...
March 27, 2018: Biosensors
https://www.readbyqxmd.com/read/29587456/review-of-stratum-corneum-impedance-measurement-in-non-invasive-penetration-application
#20
REVIEW
Fei Lu, Chenshuo Wang, Rongjian Zhao, Lidong Du, Zhen Fang, Xiuhua Guo, Zhan Zhao
Due to advances in telemedicine, mobile medical care, wearable health monitoring, and electronic skin, great efforts have been directed to non-invasive monitoring and treatment of disease. These processes generally involve disease detection from interstitial fluid (ISF) instead of blood, and transdermal drug delivery. However, the quantitative extraction of ISF and the level of drug absorption are greatly affected by the individual's skin permeability, which is closely related to the properties of the stratum corneum (SC)...
March 26, 2018: Biosensors
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