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Amy Day, Zoe Jameson, Carolyn Hyde, Bigboy Simbi, Robert Fowkes, Charlotte Lawson
Cardiovascular diseases, including atherosclerosis, now account for more deaths in the Western world than from any other cause. Atherosclerosis has a chronic inflammatory component involving Th1 pro-inflammatory cytokines such as IFN-γ, which is known to induce endothelial cell inflammatory responses. On the other hand CNP, which acts via its receptors to elevate intracellular cGMP, is produced by endothelium and endocardium and is upregulated in atherosclerosis. It is believed to be protective, however its role in vascular inflammation is not well understood...
September 14, 2018: Biosensors
Zhiyou Wang, Xiaoqing Huang, Zhiqiang Cheng
An automatic spot identification method is developed for high throughput surface plasmon resonance imaging (SPRi) analysis. As a combination of video accessing, image enhancement, image processing and parallel processing techniques, the method can identify the spots in SPRi images of the microarray from SPRi video data. In demonstrations of the method, SPRi video data of different protein microarrays were processed by the method. Results show that our method can locate spots in the microarray accurately regardless of the microarray pattern, spot-background contrast, light nonuniformity and spotting defects, but also can provide address information of the spots...
September 13, 2018: Biosensors
Ricardo A M S Corrêa, Filipe S da Cruz, Cátia C Santos, Thiago C Pimenta, Diego L Franco, Lucas F Ferreira
In this study, the electropolymerization of 4-hydroxyphenylacetic acid (4-HPA) over graphite electrodes (GE) was optimized, aiming its application as a functionalized electrochemical platform for oligonucleotides immobilization. It was investigated for the number of potential cycles and the scan rate influence on the monomer electropolymerization by using cyclic voltammetry technique. It was observed that the polymeric film showed a redox response in the region of +0.53/+0.38 V and the increase in the number of cycles produces more electroactive platforms because of the better electrode coverage...
September 11, 2018: Biosensors
Shre Kumar Chatterjee, Obaid Malik, Siddharth Gupta
In order to exploit plants as environmental biosensors, previous researches have been focused on the electrical signal response of the plants to different environmental stimuli. One of the important outcomes of those researches has been the extraction of meaningful features from the electrical signals and the use of such features for the classification of the stimuli which affected the plants. The classification results are dependent on the classifier algorithm used, features extracted and the quality of data...
September 10, 2018: Biosensors
Tongchang Zhou, Arnab Halder, Yi Sun
In this work, we developed a novel fluorescent sensor by combining molecularly imprinted polymers (MIPs) with graphene quantum dots (GQDs) for the determination of tetracycline (TC) in aqueous samples. Firstly, we developed a one-pot green method to synthesize GQDs as the fluorescent probes. GQDs with carboxyl groups or amino groups were fabricated. It was found that carboxyl groups played an important role in the fluorescence quenching. Based on these findings, the GQDs-MIPs microspheres were prepared using a sol-gel process...
September 5, 2018: Biosensors
Vladimír Pitschmann, Lukáš Matějovský, Martin Lobotka, Jan Dědič, Martin Urban, Michal Dymák
Colorimetric biosensors of cholinesterase inhibitors are ideal for fast, reliable, and very simple detection of agents in air, in water, and on surfaces. This paper describes an innovation of the Czech Detehit biosensor, which is based on a biochemical enzymatic reaction visualized by using Ellman's reagent as a chromogenic indicator. The modification basically consists of a much more distinct color response of the biosensor, attained through optimization of the reaction system by using Guinea Green B as the indicator...
September 4, 2018: Biosensors
Briliant Adhi Prabowo, Agnes Purwidyantri, Kou-Chen Liu
The notion of surface plasmon resonance (SPR) sensor research emerged more than eight decades ago from the first observed phenomena in 1902 until the first introduced principles for gas sensing and biosensing in 1983. The sensing platform has been hand-in-hand with the plethora of sensing technology advancement including nanostructuring, optical technology, fluidic technology, and light source technology, which contribute to substantial progress in SPR sensor evolution. Nevertheless, the commercial products of SPR sensors in the market still require high-cost investment, component, and operation, leading to unaffordability for their implementation in a low-cost point of care (PoC) or laboratories...
August 26, 2018: Biosensors
Peter A Haddad, Amir Servati, Saeid Soltanian, Frank Ko, Peyman Servati
The focus of this study is to design and integrate silver/silver chloride (Ag/AgCl) electronic textile (e-textile) electrodes into different textile substrates to evaluate their ability to monitor electrodermal activity (EDA). Ag/AgCl e-textiles were stitched into woven textiles of cotton, nylon, and polyester to function as EDA monitoring electrodes. EDA stimulus responses detected by dry e-textile electrodes at various locations on the hand were compared to the EDA signals collected by dry solid Ag/AgCl electrodes...
August 24, 2018: Biosensors
Pouya Soltani Zarrin, Farabi Ibne Jamal, Subhajit Guha, Jan Wessel, Dietmar Kissinger, Christian Wenger
The viscosity variation of sputum is a common symptom of the progression of Chronic Obstructive Pulmonary Disease (COPD). Since the hydration of the sputum defines its viscosity level, dielectric sensors could be used for the characterization of sputum samples collected from patients for early diagnosis of COPD. In this work, a CMOS-based dielectric sensor for the real-time monitoring of sputum viscosity was designed and fabricated. A proper packaging for the ESD-protection and short-circuit prevention of the sensor was developed...
August 21, 2018: Biosensors
Jagriti Narang, Annu Mishra, Roberto Pilloton, Alekhya Vv, Shikha Wadhwa, Chandra Shekhar Pundir, Manika Khanuja
The present study was aimed to develop "fluorine doped" tin oxide glass electrode with a MoSe2 nano-urchin based electrochemical biosensor for detection of Escherichia. coli Shiga toxin DNA. The study comprises two conductive electrodes, and the working electrodes were drop deposited using MoSe2 nano-urchin, and DNA sequences specific to Shiga toxin Escherichia. coli. Morphological characterizations were performed using Fourier transforms infrared spectrophotometer; X-ray diffraction technique and scanning electron microscopy...
August 14, 2018: Biosensors
He Li, Dimitrios P Papageorgiou, Hung-Yu Chang, Lu Lu, Jun Yang, Yixiang Deng
In red blood cell (RBC) disorders, such as sickle cell disease, hereditary spherocytosis, and diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins or changes to the extracellular environment, lead to compromised cell deformability, impaired cell stability, and increased propensity to aggregate. Numerous laboratory approaches have been implemented to elucidate the pathogenesis of RBC disorders. Concurrently, computational RBC models have been developed to simulate the dynamics of RBCs under physiological and pathological conditions...
August 10, 2018: Biosensors
Kamsul Abraha, Agung Bambang Setio Utomo
A theoretical analysis and computational study of biomaterial sample detection with surface plasmon resonance (SPR) phenomenon spectroscopy are presented in this work with the objective of achieving more sensitive detection. In this paper, a Fe₃O₄@Au core-shell, a nanocomposite spherical nanoparticle consisting of a spherical Fe₃O₄ core covered by an Au shell, was used as an active material for biomaterial sample detection, such as for blood plasma, haemoglobin (Hb) cytoplasm and lecithin, with a wavelength of 632...
August 7, 2018: Biosensors
Médéric Loyez, Jacques Albert, Christophe Caucheteur, Ruddy Wattiez
Optical fiber gratings have widely proven their applicability in biosensing, especially when they are coupled with antibodies for specific antigen recognition. While this is customarily done with fibers coated by a thin metal film to benefit from plasmonic enhancement, in this paper, we propose to study their intrinsic properties, developing a label-free sensor for the detection of biomarkers in real-time without metal coatings for surface plasmon resonances. We focus on the inner properties of our modal sensor by immobilizing receptors directly on the silica surface, and reporting the sensitivity of bare tilted fiber Bragg gratings (TFBGs) used at near infrared wavelengths...
August 3, 2018: Biosensors
Shaelyn K Houlder, Jane E Yardley
Prior to the widespread use of continuous glucose monitoring (CGM), knowledge of the effects of exercise in type 1 diabetes (T1D) was limited to the exercise period, with few studies having the budget or capacity to monitor participants overnight. Recently, CGM has become a staple of many exercise studies, allowing researchers to observe the otherwise elusive late post-exercise period. We performed a strategic search using PubMed and Academic Search Complete. Studies were included if they involved adults with T1D performing exercise or physical activity, had a sample size greater than 5, and involved the use of CGM...
August 3, 2018: Biosensors
Kristina A Malsagova, Tatyana O Pleshakova, Andrey F Kozlov, Ivan D Shumov, Mikhail A Ilnitskii, Andrew V Miakonkikh, Vladimir P Popov, Konstantin V Rudenko, Alexander V Glukhov, Igor N Kupriyanov, Nina D Ivanova, Alexander E Rogozhin, Alexander I Archakov, Yuri D Ivanov
Application of micro-Raman spectroscopy for the monitoring of quality of high-k (h-k) dielectric protective layer deposition onto the surface of a nanowire (NW) chip has been demonstrated. A NW chip based on silicon-on-insulator (SOI) structures, protected with a layer of high-k dielectric ((h-k)-SOI-NW chip), has been employed for highly sensitive detection of microRNA (miRNA) associated with oncological diseases. The protective dielectric included a 2-nm-thick Al₂O₃ surface layer and a 8-nm-thick HfO₂ layer, deposited onto a silicon SOI-NW chip...
July 27, 2018: Biosensors
Alberto Sinibaldi, Agostino Occhicone, Peter Munzert, Norbert Danz, Frank Sonntag, Francesco Michelotti
Optical biosensors based on one-dimensional photonic crystals sustaining Bloch surface waves are proposed to study antibody interactions and perform affinity studies. The presented approach utilizes two types of different antibodies anchored at the sensitive area of a photonic crystal-based biosensor. Such a strategy allows for creating two or more on-chip regions with different biochemical features as well as studying the binding kinetics of biomolecules in real time. In particular, the proposed detection system shows an estimated limit of detection for the target antibody (anti-human IgG) smaller than 0...
July 25, 2018: Biosensors
Suhith Hemanth, Arnab Halder, Claudia Caviglia, Qijin Chi, Stephan Sylvest Keller
An enzyme-based electrochemical biosensor has been developed with 3D pyrolytic carbon microelectrodes that have been coated with bio-functionalized reduced graphene oxide (RGO). The 3D carbon working electrode was microfabricated using the pyrolysis of photoresist precursor structures, which were subsequently functionalized with graphene oxide and enzymes. Glucose detection was used to compare the sensor performance achieved with the 3D carbon microelectrodes (3DCMEs) to the 2D electrode configuration. The 3DCMEs provided an approximately two-fold higher sensitivity of 23...
July 19, 2018: Biosensors
Amit Choudhary, Thomas F George, Guoqiang Li
The established role of nematic liquid crystals (NLCs) in the recent rapid development of displays has motivated researchers to modulate the electro-optical properties of LCs. Furthermore, adding nanomaterials into NLCs has led to enhancements of the properties of NLCs, like reduced threshold of the operating voltage, variation in pretilt angle, reduced switching time, etc. These enhanced properties, due to interfacial dynamics, are enabling wider applications of NLCs and nanomaterials. The recent literature of nanomaterial-doped NLCs is rich with various kinds of nanomaterials in a variety of NLCs...
July 14, 2018: Biosensors
Elisabetta M Zanetti, Giulia Pascoletti, Michele Calì, Cristina Bignardi, Giordano Franceschini
The optimization of loading protocols following dental implant insertion requires setting up patient-specific protocols, customized according to the actual implant osseointegration, measured through quantitative, objective methods. Various devices for the assessment of implant stability as an indirect measure of implant osseointegration have been developed. They are analyzed here, introducing the respective physical models, outlining major advantages and critical aspects, and reporting their clinical performance...
July 13, 2018: Biosensors
Jingyi Qiu, Bailey Keyser, Zuan-Tao Lin, Tianfu Wu
Breast cancer is a major cause of mortality in women; however, technologies for early stage screening and diagnosis (e.g., mammography and other imaging technologies) are not optimal for the accurate detection of cancer. This creates demand for a more effective diagnostic means to replace or be complementary to existing technologies for early discovery of breast cancer. Cancer neoantigens could reflect tumorigenesis, but they are hardly detectable at the early stage. Autoantibodies, however, are biologically amplified and hence may be measurable early on, making them promising biomarkers to discriminate breast cancer from healthy tissue accurately...
July 13, 2018: Biosensors
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