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Biosensors

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https://www.readbyqxmd.com/read/28420169/ultrasensitive-label-free-sensing-of-il-6-based-on-pase-functionalized-carbon-nanotube-micro-arrays-with-rna-aptamers-as-molecular-recognition-elements
#1
Farhad Khosravi, Seyed Masoud Loeian, Balaji Panchapakesan
This study demonstrates the rapid and label-free detection of Interleukin-6 (IL-6) using carbon nanotube micro-arrays with aptamer as the molecular recognition element. Single wall carbon nanotubes micro-arrays biosensors were manufactured using photo-lithography, metal deposition, and etching techniques. Nanotube biosensors were functionalized with 1-Pyrenebutanoic Acid Succinimidyl Ester (PASE) conjugated IL-6 aptamers. Real time response of the sensor conductance was monitored with increasing concentration of IL-6 (1 pg/mL to 10 ng/mL), exposure to the sensing surface in buffer solution, and clinically relevant spiked blood samples...
April 17, 2017: Biosensors
https://www.readbyqxmd.com/read/28358305/electrochemical-field-effect-transistor-utilization-to-study-the-coupling-success-rate-of-photosynthetic-protein-complexes-to-cytochrome-c
#2
Arash Takshi, Houman Yaghoubi, Jing Wang, Daniel Jun, J Thomas Beatty
Due to the high internal quantum efficiency, reaction center (RC) proteins from photosynthetic organisms have been studied in various bio-photoelectrochemical devices for solar energy harvesting. In vivo, RC and cytochrome c (cyt c; a component of the biological electron transport chain) can form a cocomplex via interprotein docking. This mechanism can be used in vitro for efficient electron transfer from an electrode to the RC in a bio-photoelectrochemical device. Hence, the success rate in coupling RCs to cyt c is of great importance for practical applications in the future...
March 30, 2017: Biosensors
https://www.readbyqxmd.com/read/28353630/detection-of-17-%C3%AE-estradiol-in-environmental-samples-and-for-health-care-using-a-single-use-cost-effective-biosensor-based-on-differential-pulse-voltammetry-dpv
#3
Yifan Dai, Chung Chiun Liu
Environmental estrogen pollution and estrogen effects on the female reproductive system are well recognized scientifically. Among the estrogens, 17 β-estradiol is a priority in environmental estrogen pollution, and it is also a major contributor to estrogen which regulates the female reproductive system. 17 β-estradiol is carcinogenic and has a tumor promotion effect relating to breast cancer, lung cancer and others. It also affects psychological well-being such as depression, fatigue and others. Thus, a simple method of detecting 17 β-estradiol will be important for both environmental estrogen pollution and health care...
March 29, 2017: Biosensors
https://www.readbyqxmd.com/read/28335390/a-simple-metallothionein-based-biosensor-for-enhanced-detection-of-arsenic-and-mercury
#4
Gordon W Irvine, Swee Ngin Tan, Martin J Stillman
Metallothioneins (MTs) are a family of cysteine-rich proteins whose biological roles include the regulation of essential metal ions and protection against the harmful effects of toxic metals. Due to its high affinity for many toxic, soft metals, recombinant human MT isoform 1a was incorporated into an electrochemical-based biosensor for the detection of As(3+) and Hg(2+). A simple design was chosen to maximize its potential in environmental monitoring and MT was physically adsorbed onto paper discs placed on screen-printed carbon electrodes (SPCEs)...
March 13, 2017: Biosensors
https://www.readbyqxmd.com/read/28273816/a-urea-potentiometric-biosensor-based-on-a-thiophene-copolymer
#5
Cheng-Yuan Kevin Lai, Peter J S Foot, John W Brown, Peter Spearman
A potentiometric enzyme biosensor is a convenient detector for quantification of urea concentrations in industrial processes, or for monitoring patients with diabetes, kidney damage or liver malfunction. In this work, poly(3-hexylthiophene-co-3-thiopheneacetic acid) (P(3HT-co-3TAA)) was chemically synthesized, characterized and spin-coated onto conductive indium tin oxide (ITO) glass electrodes. Urease (Urs) was covalently attached to the smooth surface of this copolymer via carbodiimide coupling. The electrochemical behavior and stability of the modified Urs/P(3HT-co-3TAA)/ITO glass electrode were investigated by cyclic voltammetry, and the bound enzyme activity was confirmed by spectrophotometry...
March 3, 2017: Biosensors
https://www.readbyqxmd.com/read/28257054/high-bacterial-agglutination-activity-in-a-single-crd-c-type-lectin-from-spodoptera-exigua-lepidoptera-noctuidae
#6
Leila Gasmi, Juan Ferré, Salvador Herrero
Lectins are carbohydrate-interacting proteins that play a pivotal role in multiple physiological and developmental aspects of all organisms. They can specifically interact with different bacterial and viral pathogens through carbohydrate-recognition domains (CRD). In addition, lectins are also of biotechnological interest because of their potential use as biosensors for capturing and identifying bacterial species. In this work, three C-type lectins from the Lepidoptera Spodoptera exigua were produced as recombinant proteins and their bacterial agglutination properties were characterized...
March 1, 2017: Biosensors
https://www.readbyqxmd.com/read/28241495/state-of-the-art-methods-for-skeletal-muscle-glycogen-analysis-in-athletes-the-need-for-novel-non-invasive-techniques
#7
REVIEW
Jacob Greene, Julien Louis, Olga Korostynska, Alex Mason
Muscle glycogen levels have a profound impact on an athlete's sporting performance, thus measurement is vital. Carbohydrate manipulation is a fundamental component in an athlete's lifestyle and is a critical part of elite performance, since it can provide necessary training adaptations. This paper provides a critical review of the current invasive and non-invasive methods for measuring skeletal muscle glycogen levels. These include the gold standard muscle biopsy, histochemical analysis, magnetic resonance spectroscopy, and musculoskeletal high frequency ultrasound, as well as pursuing future application of electromagnetic sensors in the pursuit of portable non-invasive quantification of muscle glycogen...
February 23, 2017: Biosensors
https://www.readbyqxmd.com/read/28218731/a-single-use-in-vitro-biosensor-for-the-detection-of-t-tau-protein-a-biomarker-of-neuro-degenerative-disorders-in-pbs-and-human-serum-using-differential-pulse-voltammetry-dpv
#8
Yifan Dai, Alireza Molazemhosseini, Chung Chiun Liu
A single-use, in vitro biosensor for the detection of T-Tau protein in phosphate-buffer saline (PBS) and undiluted human serum was designed, manufactured, and tested. Differential pulse voltammetry (DPV) served as the transduction mechanism. This biosensor consisted of three electrodes: working, counter, and reference electrodes fabricated on a PET sheet. Both working and counter electrodes were thin gold film, 10 nm in thickness. Laser ablation technique was used to define the size and structure of the biosensor...
February 19, 2017: Biosensors
https://www.readbyqxmd.com/read/28212271/carbon-nanotubes-as-an-effective-opportunity-for-cancer-diagnosis-and-treatment
#9
REVIEW
Alessandro Sanginario, Beatrice Miccoli, Danilo Demarchi
Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation...
February 15, 2017: Biosensors
https://www.readbyqxmd.com/read/28117762/composite-hydrogels-with-engineered-microdomains-for-optical-glucose-sensing-at-low-oxygen-conditions
#10
Lindsey R Bornhoeft, Aniket Biswas, Michael J McShane
There is a growing need for advanced tools that enable frequent monitoring of biomarkers for precision medicine. In this work, we present a composite hydrogel-based system providing real-time optical bioanalyte monitoring. The responsive material, alginate-in-alginate (AnA), is comprised of an alginate hydrogel with embedded bioactive, nanofilm-coated phosphorescent microdomains; palladium tetracarboxyphenylporphyrin serves as an optical indicator, glucose oxidase as a model enzyme, and layer-by-layer deposited polyelectrolyte multilayers (PEMs) as the diffusion barrier...
January 22, 2017: Biosensors
https://www.readbyqxmd.com/read/28085088/surface-enhanced-raman-scattering-based-immunoassay-technologies-for-detection-of-disease-biomarkers
#11
REVIEW
Joseph Smolsky, Sukhwinder Kaur, Chihiro Hayashi, Surinder K Batra, Alexey V Krasnoslobodtsev
Detection of biomarkers is of vital importance in disease detection, management, and monitoring of therapeutic efficacy. Extensive efforts have been devoted to the development of novel diagnostic methods that detect and quantify biomarkers with higher sensitivity and reliability, contributing to better disease diagnosis and prognosis. When it comes to such devastating diseases as cancer, these novel powerful methods allow for disease staging as well as detection of cancer at very early stages. Over the past decade, there have been some advances in the development of platforms for biomarker detection of diseases...
January 12, 2017: Biosensors
https://www.readbyqxmd.com/read/28067772/alternating-current-dielectrophoresis-collection-and-chaining-of-phytoplankton-on-chip-comparison-of-individual-species-and-artificial-communities
#12
COMPARATIVE STUDY
Coralie Siebman, Orlin D Velev, Vera I Slaveykova
The capability of alternating current (AC) dielectrophoresis (DEP) for on-chip capture and chaining of the three species representative of freshwater phytoplankton was evaluated. The effects of the AC field intensity, frequency and duration on the chaining efficiency and chain lengths of green alga Chlamydomonas reinhardtii, cyanobacterium Synechocystis sp. and diatom Cyclotella meneghiniana were characterized systematically. C. reinhardtii showed an increase of the chaining efficiency from 100 Hz to 500 kHz at all field intensities; C...
January 5, 2017: Biosensors
https://www.readbyqxmd.com/read/28054983/aptamer-sensors
#13
EDITORIAL
Giovanna Marrazza
In the last years, great progress has been accomplished in the development of aptamer sensors with different transducers. In order to improve the sensitivity of these biosensors, several methodologies have been employed. In this Special Issue, the state of art and the future trends in the field of aptamer sensors have been explored.
January 4, 2017: Biosensors
https://www.readbyqxmd.com/read/28054956/a-strategy-to-establish-a-quality-assurance-quality-control-plan-for-the-application-of-biosensors-for-the-detection-of-e-coli-in-water
#14
Nikou Hesari, Nursel Kıratlı Yılmazçoban, Mohamad Elzein, Absar Alum, Morteza Abbaszadegan
Rapid bacterial detection using biosensors is a novel approach for microbiological testing applications. Validation of such methods is an obstacle in the adoption of new bio-sensing technologies for water testing. Therefore, establishing a quality assurance and quality control (QA/QC) plan is essential to demonstrate accuracy and reliability of the biosensor method for the detection of E. coli in drinking water samples. In this study, different reagents and assay conditions including temperatures, holding time, E...
January 3, 2017: Biosensors
https://www.readbyqxmd.com/read/28045439/design-and-development-of-non-contact-bio-potential-electrodes-for-pervasive-health-monitoring-applications
#15
Anthony J Portelli, Slawomir J Nasuto
For the advent of pervasive bio-potential monitoring, it will be necessary to utilize a combination of cheap, quick to apply, low-noise electrodes and compact electronics with wireless technologies. Once available, all electrical activity resulting from the processes of the human body could be actively and constantly monitored without the need for cumbersome application and maintenance. This could significantly improve the early diagnosis of a range of different conditions in high-risk individuals, opening the possibility for new treatments and interventions as conditions develop...
January 1, 2017: Biosensors
https://www.readbyqxmd.com/read/28025564/versatile-flexible-graphene-multielectrode-arrays
#16
Dmitry Kireev, Silke Seyock, Mathis Ernst, Vanessa Maybeck, Bernhard Wolfrum, Andreas Offenhäusser
Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells...
December 23, 2016: Biosensors
https://www.readbyqxmd.com/read/27999382/rapid-detection-of-bacillus-anthracis-spores-using-immunomagnetic-separation-and-amperometry
#17
David F Waller, Brian E Hew, Charlie Holdaway, Michael Jen, Gabriel D Peckham
Portable detection and quantitation methods for Bacillus anthracis (anthrax) spores in pure culture or in environmental samples are lacking. Here, an amperometric immunoassay has been developed utilizing immunomagnetic separation to capture the spores and remove potential interferents from test samples followed by amperometric measurement on a field-portable instrument. Antibody-conjugated magnetic beads and antibody-conjugated glucose oxidase were used in a sandwich format for the capture and detection of target spores...
December 20, 2016: Biosensors
https://www.readbyqxmd.com/read/27999300/a-novel-mos-nanowire-gas-sensor-device-s3-and-gc-ms-based-approach-for-the-characterization-of-grated-parmigiano-reggiano-cheese
#18
Veronica Sberveglieri, Manohar Prasad Bhandari, Estefanía Núñez Carmona, Giulia Betto, Giorgio Sberveglieri
To determine the originality of a typical Italian Parmigiano Reggiano cheese, it is crucial to define and characterize its quality, ripening period, and geographical origin. Different analytical techniques have been applied aimed at studying the organoleptic and characteristic volatile organic compounds (VOCs) profile of this cheese. However, most of the classical methods are time consuming and costly. The aim of this work was to illustrate a new simple, portable, fast, reliable, non-destructive, and economic sensor device S3 based on an array of six metal oxide semiconductor nanowire gas sensors to assess and discriminate the quality ranking of grated Parmigiano Reggiano cheese samples and to identify the VOC biomarkers using a headspace SPME-GC-MS...
December 16, 2016: Biosensors
https://www.readbyqxmd.com/read/27918419/a-theoretical-study-of-love-wave-sensors-based-on-zno-glass-layered-structures-for-application-to-liquid-environments
#19
Cinzia Caliendo, Muhammad Hamidullah
The propagation of surface acoustic Love modes along ZnO/glass-based structures was modeled and analysed with the goal of designing a sensor able to detect changes in the environmental parameters, such as liquid viscosity changes and minute amounts of mass supported in the viscous liquid medium. Love mode propagation was modeled by numerically solving the system of coupled electro-mechanical field equations and Navier-Stokes equations. The phase and group velocities and the attenuation of the acoustic wave propagating along the 30° tilted c-axis ZnO/glass structure contacting a viscous non-conductive liquid were calculated for different ZnO guiding layer thicknesses, added mass thicknesses, and liquid viscosity and density...
December 2, 2016: Biosensors
https://www.readbyqxmd.com/read/27916817/real-time-classification-of-patients-with-balance-disorders-vs-normal-subjects-using-a-low-cost-small-wireless-wearable-gait-sensor
#20
Bhargava Teja Nukala, Taro Nakano, Amanda Rodriguez, Jerry Tsay, Jerry Lopez, Tam Q Nguyen, Steven Zupancic, Donald Y C Lie
Gait analysis using wearable wireless sensors can be an economical, convenient and effective way to provide diagnostic and clinical information for various health-related issues. In this work, our custom designed low-cost wireless gait analysis sensor that contains a basic inertial measurement unit (IMU) was used to collect the gait data for four patients diagnosed with balance disorders and additionally three normal subjects, each performing the Dynamic Gait Index (DGI) tests while wearing the custom wireless gait analysis sensor (WGAS)...
November 29, 2016: Biosensors
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