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United European Gastroenterology Journal

Grainne Holleran, Axel Dignass
No abstract text is available yet for this article.
November 2018: United European Gastroenterology Journal
Charles Murray
No abstract text is available yet for this article.
November 2018: United European Gastroenterology Journal
A G Gravina, N Prevete, C Tuccillo, C De Musis, L Romano, A Federico, A de Paulis, G D'Argenio, M Romano
Background and aims: Hp(2-20), a Helicobacter pylori- derived peptide interacting with N-formyl peptide receptors (FPRs), accelerates the healing of gastric injury in rats. Whether Hp(2-20) affects the recovery of inflamed colonic mucosa is unknown. We evaluated whether Hp(2-20) accelerated the healing of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis and explored the mechanism(s) underlying any such effect. Methods: Fifteen rats underwent rectal administration of Hp(2-20) 250-500 µg/kg/day, or of its control peptide Hp1 for 10 days, following induction of colitis with TNBS...
November 2018: United European Gastroenterology Journal
Hans Törnblom, Richard Goosey, Gwen Wiseman, Stephen Baker, Anton Emmanuel
Background: Irritable bowel syndrome with diarrhoea (IBS-D) comprises multiple troublesome symptoms and negatively impacts patients' quality of life. Objective: The objective of this article is to assess IBS-D patient burden and patient and healthcare professional (HCP) attitudes towards IBS. Methods: Patients and HCPs from Australia, Canada, France, Germany, Italy, Spain and the United Kingdom completed internet-based surveys via market research panels...
November 2018: United European Gastroenterology Journal
Nicolas Chapelle, Nicolas Musquer, Elodie Métivier-Cesbron, Dominique Luet, Christelle Volteau, Marc Le Rhun, Emmanuel Coron
Background: Endoscopic submucosal dissection is currently regarded as the method of choice for the resection of superficial tumours. The objective of our study was to evaluate prospectively the efficiency of an endoscopic submucosal dissection training course using live anaesthetised pigs. Methods: Fourteen novice endoscopists participated in three gastric endoscopic submucosal dissection training courses on anaesthetised pigs. Each trainee resected five 'fake' antral lesions...
November 2018: United European Gastroenterology Journal
Hiroaki Takaya, Hideto Kawaratani, Yuki Tsuji, Keisuke Nakanishi, Soichiro Saikawa, Shinya Sato, Yasuhiko Sawada, Kosuke Kaji, Yasushi Okura, Naotaka Shimozato, Mitsuteru Kitade, Takemi Akahane, Kei Moriya, Tadashi Namisaki, Akira Mitoro, Masanori Matsumoto, Hiroshi Fukui, Hitoshi Yoshiji
Background: Several noninvasive biomarkers are available for diagnosing liver fibrosis stage and predicting hepatocellular carcinoma (HCC) development in patients with chronic hepatitis and liver cirrhosis. However, these biomarkers are not sufficiently accurate. Recently, von Willebrand factor (VWF) has been related to angiogenesis and apoptosis. Furthermore, VWF is associated with hepatic spare ability and HCC. Objective: We aimed to determine whether VWF is a potential biomarker for liver fibrosis and HCC development...
November 2018: United European Gastroenterology Journal
Masaru Enomoto, Yoshihiro Ikura, Akihiro Tamori, Ritsuzo Kozuka, Hiroyuki Motoyama, Etsushi Kawamura, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Hiroyasu Morikawa, Yoshiki Murakami, Norifumi Kawada
Background: Interferon-free, direct-acting antiviral treatments can result in a sustained virologic response in nearly 100% of patients with chronic hepatitis C virus infection. Aims: The purpose of this study was to evaluate histological improvement after achieving a sustained virologic response to direct-acting antiviral treatments in patients with chronic hepatitis C. Methods: Among 691 patients with chronic hepatitis C who achieved a sustained virologic response to direct-acting antivirals, 51 underwent liver biopsy 41 ± 20 weeks after the end of treatment despite normal transaminase levels...
November 2018: United European Gastroenterology Journal
Lukas Sturm, Dominik Bettinger, Max Giesler, Tobias Boettler, Arthur Schmidt, Nico Buettner, Robert Thimme, Michael Schultheiss
Background and objective: Treatment with proton pump inhibitors (PPIs) has been associated with development of hepatic encephalopathy (HE). As development of HE is a major complication after implantation of a transjugular intrahepatic portosystemic shunt (TIPS), we hypothesized that PPI treatment may be associated with a higher risk of post-TIPS HE. Methods: We analyzed data of 397 patients with liver cirrhosis who received de novo TIPS implantation at the University Medical Center Freiburg, Germany...
November 2018: United European Gastroenterology Journal
Rebecca Harris, Timothy R Card, Toby Delahooke, Guruprasad P Aithal, I Neil Guha
Background: Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. Objective: The purpose of this study was to analyse the performance of two probes (M/XL) on a portable transient elastography device within an obese community population. Method: The method involved a prospective study with recruitment from a primary care practice...
November 2018: United European Gastroenterology Journal
Maria Chiara Petrone, Livia Archibugi, Edoardo Forti, Rita Conigliaro, Roberto Di Mitri, Ilaria Tarantino, Carlo Fabbri, Alberto Larghi, Sabrina Gloria Giulia Testoni, Massimiliano Mutignani, Paolo Giorgio Arcidiacono
Background: Endoscopic ultrasound (EUS)-guided drainage is the procedure of choice for pancreatic fluid collection (PFC) management. Recently developed lumen-apposing fully covered self-expandable metal stents (LAMSs) may facilitate drainage, especially of necrotic and complex PFCs. Objective: To evaluate the feasibility and efficacy of a newly developed LAMS (Nagi, Taiwong Medical Co. Ltd, South Korea) in the drainage of PFCs. Methods: Retrospective analysis of LAMS drainage of PFCs from seven centres...
November 2018: United European Gastroenterology Journal
Fabiana Zingone, Serana Massa, Basilio Malamisura, Pasquale Pisano, Carolina Ciacci
Background: As of now, no established model for the transition from childhood to adulthood in coeliac disease exists. We aim to describe the dietary compliance and the quality of life of a population of young coeliac disease patients around transition age and to develop a practical tool (TRANSIT-CeD disk) which can be used during the transition process effectively to transmit young adults to the adult healthcare giver. Methods: We consecutively recruited all coeliac disease patients with a paediatric diagnosis (≤16 years) and aged between 9 and 20 years at the time of the study...
November 2018: United European Gastroenterology Journal
Dorien Beeckmans, Danny Riethorst, Patrick Augustijns, Tim Vanuytsel, Ricard Farré, Jan Tack, Hanne Vanheel
Background: Functional dyspepsia is a common functional gastrointestinal disorder in which a variety of pathophysiological mechanisms such as increased intestinal permeability and low-grade inflammation are involved. The factor causing these alterations, however, has not been identified. Objective: We aimed to evaluate the luminal bile salt content and receptor expression in patients with functional dyspepsia and healthy volunteers. Methods: Gastroduodenoscopy was performed to obtain duodenal biopsies from 25 healthy volunteers and 25 patients with functional dyspepsia (Rome III) to measure duodenal bile salt receptor expression with Western blot...
November 2018: United European Gastroenterology Journal
Serhat Bor, Mesut Demir, Oktay Ozdemir, Kivanc Yuksel
Background: This meta-analysis aimed to assess the cardiac safety profile of domperidone treatment for the risk of cardiovascular (CV) event and QT prolongation. Methods: Data from nine studies involving 101,155 patients were used for the analysis of CV event risk, while data from eight studies involving 390 patients were used for the analysis of QT prolongation risk. Results: Meta-analysis findings suggested a significant increase in CV risk under domperidone as compared to no treatment for domperidone doses of >30 mg/day (OR: 3...
November 2018: United European Gastroenterology Journal
Dario Biasutto, Sabine Roman, Aurelien Garros, Francois Mion
Background: Esophageal shortening (ES) might be observed during high-resolution manometry (HRM), in particular after the rapid drink test (RDT). We aimed to assess its diagnostic value in patients referred for HRM. Methods: HRM of patients without previous esophagogastric surgery or endoscopic treatment was retrospectively reviewed using the Chicago Classification v3.0. ES and pan-esophageal pressurization were analyzed during the RDT (200-ml free drinking in a sitting position)...
November 2018: United European Gastroenterology Journal
Mirjam Cm van der Ende-van Loon, Wilda D Rosmolen, Saskia Houterman, Erik J Schoon, Wouter L Curvers
Background: Barrett's oesophagus affects patients' quality of life and may be a psychological burden due to the threat of developing an oesophageal adenocarcinoma. Objective: Assessing the oesophageal adenocarcinoma risk perceived by non-dysplastic Barrett's oesophagus patients and its association with quality of life, illness perception and reflux symptoms. Methods: This cross-sectional questionnaire study included 158 Barrett's oesophagus non-dysplastic patients aged 18-75 years...
November 2018: United European Gastroenterology Journal
Chih-Wei Tseng, Malcolm Koo, Kuo-Chih Tseng, Yu-Hsi Hsieh
Background: Anxious patients and those with poor tolerance to previous esophagogastroduodenoscopy (EGD) usually have poor tolerance for EGD. Aims: To investigate the effect of meperidine on these patients during EGD. Methods: A total of 110 patients undergoing diagnostic EGD were randomized to receive either meperidine ( n  = 55) or placebo ( n  = 55) before EGD. The primary outcome was patient discomfort scores during esophageal intubation...
November 2018: United European Gastroenterology Journal
Daphne Ang, Qishi Zheng, Luming Shi, Jan Tack
Background: Patients with persistent gastroesophageal reflux disease symptoms despite proton pump inhibitors are increasingly encountered. It remains controversial if proton pump inhibitors should be stopped before functional oesophageal tests. Aim: This meta-analysis compares the positive yield of oesophageal studies performed off versus on proton pump inhibitors. Methods: Pubmed, Embase and the Cochrane Library were searched for eligible studies...
November 2018: United European Gastroenterology Journal
Karn Wijarnpreecha, Susan Lou, Panadeekarn Panjawatanan, Wisit Cheungpasitporn, Surakit Pungpapong, Frank J Lukens, Patompong Ungprasert
Background/Objectives: A negative association between cigarette smoking and celiac disease has been observed but results were inconsistent across the published studies. A meta-analysis was conducted with the aim to identify all studies that investigated this association and to summarize the results of those studies. Methods: A comprehensive literature review was conducted utilizing MEDLINE and Embase databases through March 2018 to identify all cohort studies and case-control studies that compared the risk of celiac disease among current and/or former smokers versus never-smokers...
November 2018: United European Gastroenterology Journal
Jakub Fichna, Nathalie Vergnolle, Ilse Rooman
No abstract text is available yet for this article.
October 2018: United European Gastroenterology Journal
(no author information available yet)
No abstract text is available yet for this article.
October 2018: United European Gastroenterology Journal
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