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United European Gastroenterology Journal

Iago Rodríguez-Lago, Antonio López-Sanromán
No abstract text is available yet for this article.
May 2018: United European Gastroenterology Journal
Franco Bazzoli
No abstract text is available yet for this article.
May 2018: United European Gastroenterology Journal
Rita Barosa, Noor Mohammed, Bjorn Rembacken
Background and Aims: Endoscopic mucosal resection is an effective and safe procedure to manage large non-pedunculated colonic polyps for which residual/recurrent adenoma is the main drawback. Size/Morphology/Site/Access score determines polypectomy difficulty. We aimed to describe residual/recurrent adenoma rate according to Size/Morphology/Site/Access and to select the ize/Morphology/Site/Access cut-off to predict low residual/recurrent adenoma. Methods: This was a retrospective cohort study of endoscopic mucosal resection for large non-pedunculated colonic polyps performed in a tertiary centre...
May 2018: United European Gastroenterology Journal
Carolina Mangas-Sanjuan, Pedro Zapater, Joaquín Cubiella, Óscar Murcia, Luis Bujanda, Vicent Hernández, David Martínez-Ares, María Pellisé, Agustín Seoane, Ángel Lanas, David Nicolás-Pérez, Alberto Herreros-de-Tejada, María Chaparro, Guillermo Cacho, Servando Fernández-Díez, José-Carlos Marín-Gabriel, Enrique Quintero, Antoni Castells, Rodrigo Jover
Background: Guidelines recommend surveillance colonoscopies based exclusively on findings at baseline colonoscopy. This recommendation leads to the paradox that the higher the baseline colonoscopy quality, the more surveillance colonoscopies will be indicated according to current guidelines. Objective: The aim of this study was to evaluate the effect on follow-up findings of different quality metrics of the endoscopist performing the baseline colonoscopy. Methods: This retrospective cohort study included individuals with advanced adenomas at baseline colonoscopy...
May 2018: United European Gastroenterology Journal
Rosalie C Oey, Robert A de Man, Nicole S Erler, Annelies Verbon, Henk R van Buuren
Background: Recent investigations suggest an increasing prevalence of Gram-positive and antibiotic-resistant bacteria causing spontaneous bacterial peritonitis (SBP), probably related to changes in antibiotic prescription patterns, in particular more widespread and long-term use of antibiotic prophylaxis with quinolones. Objective: The primary objective of this study was to assess potential changes in the microbiology of SBP in two patient cohorts studied at a 10-year interval...
May 2018: United European Gastroenterology Journal
Cesare Cremon, Simone Guglielmetti, Giorgio Gargari, Valentina Taverniti, Anna Maria Castellazzi, Chiara Valsecchi, Carlotta Tagliacarne, Walter Fiore, Massimo Bellini, Lorenzo Bertani, Dario Gambaccini, Michele Cicala, Bastianello Germanà, Maurizio Vecchi, Isabella Pagano, Maria Raffaella Barbaro, Lara Bellacosa, Vincenzo Stanghellini, Giovanni Barbara
Background: Evidence suggests a role of intestinal microbiota-host interactions in the pathophysiology and symptoms of irritable bowel syndrome (IBS). Objective: The objective of this article is to assess the effects of Lactobacillus paracasei CNCM I-1572 on clinical and gut microbiota-related factors in IBS. Methods: We conducted a multicenter, randomized, double-blind, cross-over, 18-week, placebo-controlled, pilot trial assessing the effect of Lactobacillus paracasei CNCM I-1572 on symptoms, gut microbiota composition, fecal short chain fatty acid (SCFA), immunoglobulin A, and cytokines in IBS...
May 2018: United European Gastroenterology Journal
Clive H Wilder-Smith, Søren S Olesen, Andrea Materna, Asbjørn M Drewes
Background: Obesity is associated with changes in the intestinal microbiome and methane-producing archaea may be involved in energy homeostasis. Objective: The objective of this article is to investigate the associations between intestinal methane production, waist circumference and body mass index (BMI) as biomarkers for obesity. Methods: Breath methane and hydrogen concentrations were measured over five hours following fructose or lactose ingestion in 1647 patients with functional gastrointestinal disorders...
May 2018: United European Gastroenterology Journal
Bonna Leerhøy, Daniel M Shabanzadeh, Andreas Nordholm-Carstensen, Srdan Novovic, Mark B Hansen, Lars N Jørgensen
Background: Acute pancreatitis is one of the most common causes of gastrointestinal-related hospitalization and the incidence is increasing. Endo- and exocrine pancreatic function can be compromised after acute pancreatitis. Objective: The purpose of this study was to explore the long-term consequences of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) on pancreatic function. Methods: A follow-up study was carried out with prospective assessment of endo- and exocrine pancreatic function among cases with previous PEP and matched controls from a Danish cohort consisting of 772 patients undergoing first-time ERCP...
May 2018: United European Gastroenterology Journal
Kwang Hyun Chung, Sang Hyub Lee, Jin Ho Choi, Jinwoo Kang, Woo Hyun Paik, Dong-Won Ahn, Ji Kon Ryu, Yong-Tae Kim
Background: The role of submucosal injection (SI) in endoscopic papillectomy (EP) is controversial. Objective: This study investigated the effects of SI before EP of ampullary tumors. Methods: All patients who underwent initial curative EP at our institution between March 2006 and March 2014 were retrospectively recruited. The presence of residual tumor after three months, recurrence-free survival and post-procedural adverse events were compared between the SI group and non-injection (NI) group...
May 2018: United European Gastroenterology Journal
Valma Fuchs, Kalle Kurppa, Heini Huhtala, Markku Mäki, Leila Kekkonen, Katri Kaukinen
Background: Celiac disease is challenging to recognize, predisposing to long diagnostic delay. Currently, associated factors and significance of the delay remain obscure. Objective: The objective of this article is to investigate associated sociodemographic risk factors and health consequences of diagnostic delay in celiac disease. Methods: Altogether 611 patients were surveyed at diagnosis and after one year on a gluten-free diet regarding sociodemographic variables, well-being and use of medicines and health care services...
May 2018: United European Gastroenterology Journal
Shaohang Cai, Zejin Ou, Duan Liu, Lili Liu, Ying Liu, Xiaolu Wu, Tao Yu, Jie Peng
Background: We investigated whether metabolic syndrome exacerbated the risk of liver fibrosis among chronic hepatitis B patients and risk factors associated with liver steatosis and fibrosis in chronic hepatitis B patients with components of metabolic syndrome. Methods: This study included 1236 chronic hepatitis B patients with at least one component of metabolic syndrome. The controlled attenuation parameter and liver stiffness, patient information and relevant laboratory data were recorded...
May 2018: United European Gastroenterology Journal
Ricardo Küttner-Magalhães, Mário Dinis-Ribeiro, Marco J Bruno, Ricardo Marcos-Pinto, Carla Rolanda, Arjun D Koch
Introduction: Endoscopic mucosal resection and endoscopic submucosal dissection are demanding procedures. This study aims to establish face, content and expert validity of the live porcine model in performing endoscopic mucosal resection, endoscopic submucosal dissection, complication management and to assess it as a training tool. Material and methods: Tutors and trainees participating in live porcine model endoscopic mucosal resection and endoscopic submucosal dissection workshops filled out a questionnaire regarding the realism of the model compared to human setting and its role as a learning tool...
May 2018: United European Gastroenterology Journal
Thorsten Brechmann, Christoph Maier, Miriam Kaisler, Jan Vollert, Wolff Schmiegel, Svetlana Pak, Norbert Scherbaum, Fred Rist, Andrea Riphaus
Background: Propofol is recommended for sedation in gastrointestinal endoscopy (GE), but preliminary data suggest addictive potentials. Objective: The objective of this article is to evaluate the frequency of predominantly euphoric reaction after GE and patients' subsequent reminiscences. Methods: Eighty-two patients undergoing elective GE under propofol sedation were enrolled in a prospective observational study. The grade of anxiety, expectation or relief about the examination's result and affective state in terms of cheerfulness, relaxation, activation, sedation and anxiety were surveyed using a numeric rating scale (1 to 10) immediately before (t1), after GE (t2) and seven days (t3) later...
May 2018: United European Gastroenterology Journal
Seth A Gross, Michael S Smith, Vivek Kaul
Background: Barrett's esophagus (BE) and esophageal dysplasia (ED) are frequently missed during screening and surveillance esophagoscopy because of sampling error associated with four-quadrant random forceps biopsy (FB). Aim: The aim of this article is to determine if wide-area transepithelial sampling with three-dimensional computer-assisted analysis (WATS) used adjunctively with FB can increase the detection of BE and ED. Methods: In this multicenter prospective trial, patients screened for suspected BE and those with known BE undergoing surveillance were enrolled...
May 2018: United European Gastroenterology Journal
Margreet van Putten, Brian T Johnston, Liam J Murray, Anna T Gavin, Damian T McManus, Shivaram Bhat, Richard C Turkington, Helen G Coleman
Background: A systematic review suggests that 25% of oesophageal adenocarcinomas (OAC) are 'missed' at index endoscopy for Barrett's oesophagus (BO); however, this included few population-based studies and may be an overestimate. Objective: The objective of this article is to quantify the 'missed' rates of high-grade dysplasia (HGD) and OAC at index BO endoscopy. Methods: Patients from the Northern Ireland BO register diagnosed between 1993 and 2010 ( n  = 13,159) were linked to the Northern Ireland Cancer Registry to identify patients who developed OAC or HGD...
May 2018: United European Gastroenterology Journal
Ans Pauwels, Charlotte Broers, Tim Vanuytsel, Nicolas Pardon, Silvia Cocca, Sabine Roman, Frank Zerbib, Jan Tack, Ricard Farré
Introduction: Approximately 30% of healthy volunteers (HVs) show dilated intercellular spaces in the esophageal epithelium suggesting a functionally reduced epithelial integrity. We aimed to evaluate the presence of an altered epithelial integrity in HVs and whether physiological acid could explain such a difference. Methods: Biopsies for Ussing chamber experiments were taken between 3 cm and 5 cm proximal to the gastroesophageal junction. Twenty-four-hour impedance-pH (MII-pH) monitoring was performed in the same 15 HVs...
May 2018: United European Gastroenterology Journal
C Hassan, A Repici, D K Rex
No abstract text is available yet for this article.
May 2018: United European Gastroenterology Journal
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Omar Y Mousa, Wisit Cheungpasitporn, Surakit Pungpapong, Patompong Ungprasert
Background/Objectives: Studies have suggested that smokers may have a lower risk of primary sclerosing cholangitis (PSC) although the results have been inconsistent. This systematic review and meta-analysis was conducted to summarize all available data to better characterize this association. Methods: A comprehensive literature review was conducted using Medline and Embase databases through January 2018 to identify all studies that compared the risk of PSC among current/former smokers versus nonsmokers...
May 2018: United European Gastroenterology Journal
Marianna Signoretti, Marco J Bruno, Giulia Zerboni, Jan-Werner Poley, Gianfranco Delle Fave, Gabriele Capurso
Background: Data on surveillance for pancreatic ductal adenocarcinoma (PDAC) in high-risk individuals (HRIs) with "familial pancreatic cancer" (FPC) and specific syndromes are limited and heterogeneous. Objective: We conducted a systematic review and meta-analysis of PDAC surveillance studies in HRIs. Methods: Prevalence of solid/cystic pancreatic lesions and of lesions considered a successful target of surveillance (proven resectable PDAC and high-grade precursors) was pooled across studies...
May 2018: United European Gastroenterology Journal
Julia Krajewska, Louis Vermeulen
No abstract text is available yet for this article.
April 2018: United European Gastroenterology Journal
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