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United European Gastroenterology Journal

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October 2016: United European Gastroenterology Journal
Aleksander Krag, Maja Thiele
No abstract text is available yet for this article.
October 2016: United European Gastroenterology Journal
Herbert Tilg
No abstract text is available yet for this article.
October 2016: United European Gastroenterology Journal
Salvatore Chirumbolo
The recent paper by Nucera et al., showed that the basophil activation test (BAT) in flow cytometry is able to monitor an acquired tolerance induced by a desensitization treatment in food allergy. The paper by Nucera et al. reported two standpoints in the CD63 response to food allergy and OAT and their large difference in CD63 response before and after suggests for the optimal performance of a CD123/HLADR/CD63 BAT in oral food allergy immunotherapy.
October 2016: United European Gastroenterology Journal
Jason M Haas, Maharaj Singh, Nimish Vakil
BACKGROUND: The surgical treatment of diverticulitis is in a state of evolution. Clinicians across many disciplines need to counsel patients regarding surgical choices. OBJECTIVES: A systematic review and meta-analysis was conducted to determine the mortality and complication rates following surgery for diverticulitis in both the emergent and elective setting. METHODS: We searched PubMed, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL) for relevant articles published from 1980 to 2012...
October 2016: United European Gastroenterology Journal
Gabriele Capurso, Marianna Signoretti, Livia Archibugi, Serena Stigliano, Gianfranco Delle Fave
BACKGROUND: Evidence on small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP) is conflicting. AIM: The purpose of this study was to perform a systematic review and meta-analysis on the prevalence of SIBO in CP and to examine the relationship of SIBO with symptoms and nutritional status. METHODS: Case-control and cross-sectional studies investigating SIBO in CP patients were analysed. The prevalence of positive tests was pooled across studies, and the rate of positivity between CP cases and controls was calculated...
October 2016: United European Gastroenterology Journal
Lars Agréus, Per M Hellström, Nicholas J Talley, Bengt Wallner, Anna Forsberg, Michael Vieth, Lothar Veits, Karin Björkegren, Lars Engstrand, Anna Andreasson
BACKGROUND: In Western countries the prevalence of Helicobacter pylori (H. pylori) infection may be declining but there is a lack of recent longitudinal population studies. We evaluated the changing epidemiology over a 23-year period in Sweden. MATERIALS AND METHODS: In 1989, the validated Abdominal Symptom Questionnaire (ASQ) was mailed to a random sample of inhabitants (ages 22-80 years) in a Swedish community, and 1097 (87%) responded. H. pylori serology was analysed in a representative subsample (n = 145)...
October 2016: United European Gastroenterology Journal
Tao Tian, Weiliang Tian, Fan Yang, Risheng Zhao, Qian Huang, Yunzhao Zhao
BACKGROUND: Sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptors (S1PRs) signaling plays a key role in inflammatory responses. Lei et al. showed that SphK1 inhibition presented a hepatoprotective effect on acute liver damage via decreasing hepatic high-mobility group box 1 (HMGB1) cytoplasmic translocation. OBJECTIVE: We aim to determine whether SphK1 or S1PRs inhibition improves lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced acute liver failure by inhibiting the mitogen-activated protein kinases (MAPKs) pathway...
October 2016: United European Gastroenterology Journal
Solvey Schüle, Jean-Benoît Rossel, Diana Frey, Luc Biedermann, Michael Scharl, Jonas Zeitz, Natália Freitas-Queiroz, Valérie Pittet, Stephan R Vavricka, Gerhard Rogler, Benjamin Misselwitz
BACKGROUND: Low bone mineral density (BMD) remains a frequent problem in patients with inflammatory bowel diseases (IBD). There is no general agreement regarding osteoporosis screening in IBD patients. METHODS: Cases of low BMD and disease characteristics were retrieved from 3172 patients of the Swiss IBD cohort study. Multivariate logistic regression analysis was conducted for predictive modeling. In a subgroup of 877 patients, 253 dual-energy X-ray absorptiometry (DXA) scans were available for validation...
October 2016: United European Gastroenterology Journal
E Werbrouck, G De Hertogh, X Sagaert, G Coremans, H Willekens, I Demedts, R Bisschops
BACKGROUND: Endoscopic resection (ER) with or without ablation is the first choice treatment for early Barrett's neoplasia. Adequate staging is important to assure a good oncological outcome. OBJECTIVE: The purpose of this study was to investigate the diagnostic accuracy of pre-operative biopsies in patients who undergo ER for high-grade dysplasia (HGD) or early adenocarcinoma (EAC) in Barrett's oesophagus (BE) and the cardia. METHODS: Between November 2005-May 2012, 142 ERs performed in 137 patients were obtained...
October 2016: United European Gastroenterology Journal
Angela Bureo Gonzalez, Jacques Jghm Bergman, Roos E Pouw
Barrett's oesophagus is a precursor lesion for oesophageal adenocarcinoma, which generally has a poor prognosis. Patients diagnosed with Barrett's oesophagus therefore undergo regular endoscopic surveillance to detect neoplastic lesions at a curable stage. The efficacy of endoscopic surveillance of Barrett's oesophagus patients is, however, hampered by difficulties to detect early neoplasia endoscopically, biopsy sampling error, inter-observer variability in histological assessment and the relatively low overall progression rate...
October 2016: United European Gastroenterology Journal
Raf Bisschops, Miguel Areia, Emmanuel Coron, Daniela Dobru, Bernd Kaskas, Roman Kuvaev, Oliver Pech, Krish Ragunath, Bas Weusten, Pietro Familiari, Dirk Domagk, Roland Valori, Michal F Kaminski, Cristiano Spada, Michael Bretthauer, Cathy Bennett, Carlo Senore, Mário Dinis-Ribeiro, Matthew D Rutter
No abstract text is available yet for this article.
October 2016: United European Gastroenterology Journal
Tomer Adar, Charles Murray
No abstract text is available yet for this article.
August 2016: United European Gastroenterology Journal
Axel Dignass
No abstract text is available yet for this article.
August 2016: United European Gastroenterology Journal
Sílvia Roure, Lluís Valerio, Xavier Vallès, Betty Morales, M Immaculada Garcia-Diaz, M Luisa Pedro-Botet, Jordi Serra
BACKGROUND: Immigration-related new diseases pose a growing challenge for healthcare services in receptor countries. Following Latin American migration, Chagas disease has inevitably appeared in Europe. AIM: To determine the prevalence and characteristics of oesophageal motility disorders in immigrants infected with Trypanosoma cruzi, using high resolution oesophageal manometry (HREM). METHODS: In all newly-diagnosed cases with chronic Chagas infection referring upper digestive symptoms, a protocolized clinical evaluation and complementary tests including barium oesophagogram and HREM were carried out...
August 2016: United European Gastroenterology Journal
Antonio Tursi, Giovanni Brandimarte, Francesco Di Mario, Maria L Annunziata, Mauro Bafutto, Maria A Bianco, Raffaele Colucci, Rita Conigliaro, Silvio Danese, Rudi De Bastiani, Walter Elisei, Ricardo Escalante, Roberto Faggiani, Luciano Ferrini, Giacomo Forti, Giovanni Latella, Maria G Graziani, Enio C Oliveira, Alfredo Papa, Antonio Penna, Piero Portincasa, Kjetil Søreide, Antonio Spadaccini, Paolo Usai, Stefanos Bonovas, Carmelo Scarpignato, Marcello Picchio, Piera G Lecca, Costantino Zampaletta, Claudio Cassieri, Alberto Damiani, Kari F Desserud, Serafina Fiorella, Rosario Landi, Elisabetta Goni, Maria A Lai, Flavia Pigò, Gianluca Rotondano, Giuseppe Schiaccianoce
BACKGROUND: Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification has been recently developed for patients suffering from diverticulosis and diverticular disease. AIMS: We assessed retrospectively the predictive value of DICA in patients for whom endoscopic data and clinical follow-up were available. METHODS: For each patient, we recorded: age, severity of DICA, presence of abdominal pain, C-reactive protein and faecal calprotectin test (if available) at the time of diagnosis; months of follow-up; therapy taken during the follow-up to maintain remission (if any); occurrence/recurrence of diverticulitis; need of surgery...
August 2016: United European Gastroenterology Journal
Neil D Parikh, Joanna Gibson, Anil Nagar, Ali A Ahmed, Harry R Aslanian
BACKGROUND AND AIMS: Sessile serrated adenomas/polyps (SSA/Ps) are difficult to differentiate from non-neoplastic tissue on white-light endoscopy. Confocal laser endomicroscopy (CLE) provides subcellular imaging and real-time "optical biopsy". The aim of this study was to prospectively describe CLE features of SSA/Ps. PATIENTS AND METHODS: Consecutive patients with SSA/Ps were prospectively evaluated with probe-based CLE imaging. CLE images and polyp histology were independently reviewed by three endoscopists and an expert gastrointestinal (GI) pathologist...
August 2016: United European Gastroenterology Journal
Arnaldo Amato, Franco Radaelli, Giancarlo Spinzi
BACKGROUND: Underwater endoscopic mucosal resection without submucosal injection has been described for removing large flat colorectal lesions. OBJECTIVE: We aim to evaluate the reproducibility of this technique in terms of ease of implementation, safety and efficacy. METHODS: A prospective observational study of consecutive underwater endoscopic mucosal resection in a community hospital was performed. RESULTS: From September 2014 to April 2015, 25 flat or sessile colorectal lesions (median size 22...
August 2016: United European Gastroenterology Journal
Robert Jc Steele, Greig Stanners, Jaroslaw Lang, David H Brewster, Francis A Carey, Callum G Fraser
BACKGROUND: Little is known about interval cancers (ICs) in colorectal cancer (CRC) screening. OBJECTIVE: The purpose of this study was to identify IC characteristics and compare these with screen-detected cancers (SCs) and cancers in non-participants (NPCs) over the same time period. DESIGN: This was an observational study done in the first round of the Scottish Bowel Screening Programme. All individuals (772,790), aged 50-74 years, invited to participate between 1 January 2007 and 31 May 2009 were studied by linking their screening records with confirmed CRC records in the Scottish Cancer Registry (SCR)...
August 2016: United European Gastroenterology Journal
Enrique Pérez-Cuadrado Robles, Frédérique Maire, Jérôme Cros, Marie-Pierre Vullierme, Vinciane Rebours, Alain Sauvanet, Alain Aubert, Safi Dokmak, Philippe Lévy, Philippe Ruszniewski
OBJECTIVE: To determine accuracy of 2012 International Consensus Guidelines (ICG) predicting malignancy in a surgical cohort of branch-duct intraductal papillary mucinous neoplasms (BD-IPMN). METHODS: This study included all consecutive patients with final pathological diagnosis of pure BD-IPMN resected between 2006 and 2014 at Beaujon Hospital. Neoplasms were classified as malignant in presence of high-grade dysplasia (HGD) or invasive carcinoma. Medical, pathological, and radiological data were retrospectively recorded...
August 2016: United European Gastroenterology Journal
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