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United European Gastroenterology Journal

Paula Mosinska, Raquel Abalo
No abstract text is available yet for this article.
March 2018: United European Gastroenterology Journal
Jordi Gordillo, Yamile Zabana, Esther Garcia-Planella, Míriam Mañosa, Jordina Llaó, Ignasi Gich, Laura Marín, Justyna Szafranska, Sergio Sáinz, Xavier Bessa, Eduard Cabré, Eugeni Domènech
Background: Patients with ulcerative colitis (UC) have an increased risk of colorectal cancer. Scarce data regarding the development of adenomas in these patients are available both for normal and colitic mucosa. Objective: The objective of this article is to evaluate the prevalence of adenomatous polyps and associated risk factors in patients with UC. Methods: Patients with UC were identified from the databases of two tertiary referral centers...
March 2018: United European Gastroenterology Journal
Petra Baji, László Gulácsi, Valentin Brodszky, Zsuzsanna Végh, Silvio Danese, Peter M Irving, Laurent Peyrin-Biroulet, Stefan Schreiber, Fanni Rencz, Péter L Lakatos, Márta Péntek
Background: In clinical practice, treatment sequences of biologicals are applied for active fistulising Crohn's disease, however underlying health economic analyses are lacking. Objective: The purpose of this study was to analyse the cost-effectiveness of different biological sequences including infliximab, biosimilar-infliximab, adalimumab and vedolizumab in nine European countries. Methods: A Markov model was developed to compare treatment sequences of one, two and three biologicals from the payer's perspective on a five-year time horizon...
March 2018: United European Gastroenterology Journal
Cecilia Grinsvall, Hans Törnblom, Jan Tack, Lukas Van Oudenhove, Magnus Simrén
Background and objective: Psychological states may interfere with visceral sensitivity. Here we investigate associations between psychosocial factors and visceral sensitivity in irritable bowel syndrome (IBS). Methods: Two IBS patient cohorts (Cohort 1: n  = 231, Rome II; Cohort 2: n  = 141, Rome III) underwent rectal barostat testing, and completed questionnaires for anxiety, depression, somatization, and abuse. The associations between questionnaire measures and visceral sensitivity parameters were analyzed in three-step general linear models (step1: demographic and abuse variables; step 2: anxiety and depression; step 3: somatization)...
March 2018: United European Gastroenterology Journal
Andreas W Berger, Katja Raedler, Cord Langner, Leopold Ludwig, Nektarios Dikopoulos, Karl F Becker, Julia Slotta-Huspenina, Michael Quante, Daniel Schwerdel, Lukas Perkhofer, Alexander Kleger, Eugen Zizer, Franz Oswald, Thomas Seufferlein, Alexander Meining
Background and objective: Current surveillance strategies for colorectal cancer following polypectomy are determined by endoscopic and histopathological factors. Such a distinction has been challenged. The present study was designed to identify molecular parameters in colonic polyps potentially defining new sub-groups at risk. Methods: One hundred patients were enrolled in this multicentre study. Polyps biopsies underwent formalin-free processing (PAXgene, PreAnalytiX) and targeted next generation sequencing (38 genes (QIAGEN), NextSeq 500 platform (Illumina))...
March 2018: United European Gastroenterology Journal
Alida Andrealli, Silvia Paggi, Arnaldo Amato, Emanuele Rondonotti, Gianni Imperiali, Nicoletta Lenoci, Giovanna Mandelli, Natalia Terreni, Giancarlo Spinzi, Franco Radaelli
Background: A split-dose (SD) regimen is crucial for colonoscopy quality. Compliance with SD for early morning colonoscopy is generally poor. The present study evaluated whether pre-colonoscopy counselling, in addition to a dedicated leaflet, might increase SD uptake. Methods: Consecutive 50-69-year-old patients undergoing screening colonoscopy before 10 a.m. were randomized to either receive written information only on bowel preparation (Written Group, WG) or written and oral instructions (Written and Oral Group, WaOG)...
March 2018: United European Gastroenterology Journal
M Sasikala, V V Ravikanth, K Murali Manohar, Neha Deshpande, Sandhya Singh, P Pavan Kumar, R Talukdar, Sudip Ghosh, Mohsin Aslam, G V Rao, R Pradeep, D Nageshwar Reddy
Objectives: Altered immune homeostasis and involvement of T cells has been reported in chronic pancreatitis (CP). We evaluated the role of Bach2 (BTB and CNC homology basic leucine zipper transcription factor 2), a key regulator of immune homeostasis in the chronicity of CP. Methods: Expression of Bach2 and T-cell transcription factors, enumeration of BACH2+/CD4+ T-lymphocytes were performed by qRT-PCR and flow cytometry respectively. Bach2 silenced human CD4+ T-lymphocytes were exposed to CP tissue extract to assess T-cell lineage commitment...
March 2018: United European Gastroenterology Journal
Sara Kammerer, Tobias Meister, Heiner Wolters, Matthias Lessing, Anna Hüsing, Dirk Domagk, Martin Floer, Christian Wilms, Hartmut Schmidt, Norbert Senninger, Gabriele Köhler, Hauke Sebastian Heinzow
Background: Perihilar cholangiocarcinomas are often considered incurable. Late diagnosis is common. Advanced disease therefore frequently causes questioning of curative surgical outcome. Aim: This study aimed to develop a prediction model of curative surgery in patients suffering from perihilar cholangiocarcinomas based on preoperative endosonography and computer tomography. Methods: A cohort of 81 patients (median age 67 (54-75) years, 62% male) with perihilar cholangiocarcinoma was retrospectively analyzed...
March 2018: United European Gastroenterology Journal
Christian Rupp, Alexander Rössler, Taotao Zhou, Conrad Rauber, Kilian Friedrich, Andreas Wannhoff, Karl-Heinz Weiss, Peter Sauer, Peter Schirmacher, Caner Süsal, Wolfgang Stremmel, Daniel N Gotthardt
Background: The median age of diagnosis of primary sclerosing cholangitis (PSC) is ∼30-40 years. Objective: We aimed to analyse disease progression and liver-dependent survival in patients diagnosed with PSC after 50 years of age. Methods: Patients with PSC were analysed with regard to their age at diagnosis. Patients with a first diagnosis of PSC after the age of 50 years were considered as the late-onset group. Results: A total of 32/215 (14...
March 2018: United European Gastroenterology Journal
Hella Wobser, Tanja Paur, Elisabeth Schnoy, Janine Hartl, Gabriele I Kirchner
Background: Several years ago the International Autoimmune Hepatitis Group simplified the previous revised original scoring system for diagnosis of autoimmune hepatitis (AIH) into a scoring system based on only four instead of 13 parameters. Objective: We aimed to evaluate the suitability of the simplified AIH score for diagnosis of AIH in a German cohort with chronic liver diseases. Methods: In this retrospective single-center study, we compared the accuracy of both AIH scores in 70 patients with AIH and 211 patients with chronic liver diseases (PBC ( n  = 52), PSC ( n  = 27), NASH ( n  = 67), DILI ( n  = 15), CHB/C ( n  = 50))...
March 2018: United European Gastroenterology Journal
Martha M Kirstein, Torsten Voigtländer, Nora Schweitzer, Jan B Hinrichs, Jens Marquardt, Marcus-Alexander Wörns, Roman Kloeckner, Thorben W Fründt, Harald Ittrich, Frank Wacker, Thomas Rodt, Michael P Manns, Henning Wege, Arndt Weinmann, Arndt Vogel
Background: Sorafenib is the recommended treatment for advanced hepatocellular carcinoma (HCC), but transarterial chemoembolization (TACE) is performed in individual cases with limited extrahepatic spread. The aim of this study was to compare the outcome of patients with HCC and extrahepatic disease (EHD) treated with sorafenib and TACE. Methods: A total of 172 patients with HCC and EHD treated with sorafenib ( n  = 98) or TACE ( n  = 74) at three German referral centers (Hannover, Mainz and Hamburg) were included in this study...
March 2018: United European Gastroenterology Journal
Filomena Morisco, Rocco Granata, Silvia Camera, Antonio Ippolito, Michele Milella, Fabio Conti, Chiara Masetti, Antonella Smedile, Paolo Tundo, Teresa Santantonio, Maria Rosa Valvano, Antonio Termite, Pietro Gatti, Vincenzo Messina, Angelo Iacobellis, Marta Librandi, Nicola Caporaso, Angelo Andriulli
Background and aim: Direct antiviral agents (DAAs) have led to high sustained virological responses (SVR) in hepatitis C virus (HCV) patients. However, genotype 3 patients respond to treatment in a suboptimal way. This study aims to identify which of the several treatment schedules recommended for genotype 3 would constitute the best option. Methods: Twenty-four Italian centers were involved in this real-life study of HCV genotype 3 patients treated with DAAs. To expand the number of cases, we conducted a systematic review of the literature on the outcome of genotype 3 patients treated with DAAs...
March 2018: United European Gastroenterology Journal
Christoph Höner Zu Siederdissen, Peter Buggisch, Klaus Böker, Eckart Schott, Hartwig Klinker, Anita Pathil, Heike Pfeiffer-Vornkahl, Thomas Berg, Christoph Sarrazin, Dietrich Hüppe, Michael P Manns, Stefan Mauss
Background: In pivotal studies with direct-acting antivirals (DAAs), rates of sustained virological response in hepatitis C genotype 1 infection are >90%. Objective: The objective of this article is to assess real-world safety and effectiveness of DAA treatment in a prospective multicenter registry study. Methods: The German Hepatitis C-Registry includes 6606 patients with genotype 1 from 246 centers, treated between February 2014 and June 2016 at the discretion of the physician...
March 2018: United European Gastroenterology Journal
Lucio Petruzziello, Mariachiara Campanale, Cristiano Spada, Riccardo Ricci, Cesare Hassan, Gaia Gullo, Guido Costamagna
Background: Endoscopic submucosal dissection (ESD) allows "en bloc" resection of superficial gastric lesions. Objective: The aim of this study is to report "en bloc" resection rate, procedure results, post resection features, analysis of complications, and relapses at mid-long term follow-up on an Italian center case series of patients with superficial gastric neoplastic lesions treated with ESD. Methods: This is a retrospective evaluation of a prospectively collected series of patients diagnosed with gastric superficial lesions who underwent ESD between November 2007 and May 2015...
March 2018: United European Gastroenterology Journal
Miguel Areia, Manon Cw Spaander, Ernst J Kuipers, Mário Dinis-Ribeiro
Background: Endoscopic screening for gastric cancer is debatable in countries with an intermediate risk. Objective: The objective of this article is to determine the cost-utility of screening strategies for gastric cancer in a European country. Methods: We conducted a cost-utility analysis using a Markov model comparing three screening strategies versus no screening: stand-alone upper endoscopy, endoscopy combined with a colorectal cancer screening colonoscopy after a positive faecal occult blood test or pepsinogens serologic screening...
March 2018: United European Gastroenterology Journal
Konstantinos C Fragkos, Alastair Forbes
Background: Citrulline has been described as a marker of intestinal function or absorption but evidence varies according to clinical settings. Objective: The objective of this article is to examine the evidence of plasma citrulline as a marker of intestinal function and absorption in various clinical settings. Methods: Studies were examined for p values, means and standard deviations, correlation coefficients or other metrics depicting the association of citrulline with intestinal function...
March 2018: United European Gastroenterology Journal
Jiayi Cai, Chunyang Zhao, Yajie Du, Yaqiong Zhang, Mingyi Zhao, Qingchun Zhao
Background: Probiotics are commonly used for the prevention of antibiotic-associated diarrhea (AAD). However, the optimum regimen remains controversial. Objective: The objective of this article is to compare and rank the relative efficacy and tolerability among all available probiotic agents for AAD through a network meta-analysis. Methods: Eligible studies were identified by searching PubMed, Embase, Medline, Cochrane library and Web of Science for randomized controlled trials (RCTs) that examined the efficacy of probiotic therapy for AAD...
March 2018: United European Gastroenterology Journal
Radislav Nakov, Markus Peck-Radosavljevic
No abstract text is available yet for this article.
February 2018: United European Gastroenterology Journal
(no author information available yet)
No abstract text is available yet for this article.
February 2018: United European Gastroenterology Journal
Börje Jonefjäll, Magnus Simrén, Anders Lasson, Lena Öhman, Hans Strid
Background: Patients with ulcerative colitis often report fatigue. Objectives: To investigate prevalence of and risk factors for fatigue in patients with ulcerative colitis with active disease and during deep remission. Methods: In this cross-sectional study, disease activity was evaluated with endoscopy and calprotectin, and patients were classified as having active disease ( n = 133) or being in deep remission ( n = 155). Blood samples were analysed to assess anaemia, iron deficiency and systemic immune activity...
February 2018: United European Gastroenterology Journal
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