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United European Gastroenterology Journal

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https://www.readbyqxmd.com/read/28588893/e-learning-in-gastroenterology-what-have-we-learned-so-far
#1
Tomer Adar
No abstract text is available yet for this article.
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588892/young-gi-angle-effective-data-presentation
#2
Maciej Salaga, Simon Leedham
No abstract text is available yet for this article.
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588891/prevalence-and-clinical-features-of-opioid-induced-constipation-in-the-general-population-a-french-study-of-15-000-individuals
#3
P Ducrotté, J Milce, C Soufflet, C Fabry
BACKGROUND: Constipation is common during opioid therapy and can compromise analgesia. AIM: The aim of this article is to determine the prevalence and clinical characteristics of opioid-induced constipation (OIC) in France. METHODS: A questionnaire study was conducted in a representative sample of the French general population. Participants completed a 31-item questionnaire covering opioid use during the previous six months, and the occurrence of constipation (defined as <3 bowel movements per week, straining during defaecation, or both) during opioid treatment...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588890/cognitive-impairment-in-crohn-s-disease-is-associated-with-systemic-inflammation-symptom-burden-and-sleep-disturbance
#4
Daniel R van Langenberg, Greg W Yelland, Stephen R Robinson, Peter R Gibson
BACKGROUND: Patients with Crohn's disease (CD) frequently complain of cognitive difficulties such as problems with concentration and clouding of thought, yet this has scarcely been objectively defined and underlying mechanisms remain unknown. OBJECTIVE: The objective of this article is to objectively measure cognitive impairments in patients with CD compared with healthy controls, and if present, to identify potentially modifiable, contributing factors associated with cognitive impairment...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588889/validation-of-the-crohn-s-and-ulcerative-colitis-questionnaire-in-patients-with-acute-severe-ulcerative-colitis
#5
Hayley A Hutchings, Laith Alrubiay, Alan Watkins, W-Y Cheung, Anne C Seagrove, John G Williams
BACKGROUND: The Crohn's and Ulcerative Colitis questionnaire (CUCQ) has previously been validated in patients with mild to moderate Crohn's and ulcerative colitis (UC). The aim of this study was to validate the tool in patients with acute severe UC. METHODS: We undertook a validation of the CUCQ in patients recruited to the COmparison of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis Trial (CONSTRUCT). We carried out psychometric analysis to examine the underlying dimensions of the scale, internal consistency and construct validity...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588888/thioguanine-in-inflammatory-bowel-disease-long-term-efficacy-and-safety
#6
Mark G Ward, Kamal V Patel, Viraj C Kariyawasam, Rishi Goel, Ben Warner, Tim R Elliott, Paul A Blaker, Peter M Irving, Anthony M Marinaki, Jeremy D Sanderson
BACKGROUND: Thioguanine (TG) is efficacious in inflammatory bowel disease (IBD), but its toxicity, particularly nodular regenerative hyperplasia (NRH) of the liver, has limited its use. We assessed the long-term clinical outcomes and safety of TG in patients whom were intolerant or refractory to conventional immunomodulators. METHODS: This is a retrospective, single-centre study of IBD patients treated with TG from 2001-2013. Response was defined as clinical remission (Harvey-Bradshaw Index < 5 for Crohn's disease (CD), Simple Clinical Colitis Activity Index < 4 for ulcerative colitis (UC)) without corticosteroids or, if receiving anti-tumour-necrosis-factor (anti-TNF) therapy, absence of dose escalation...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588887/risk-factors-for-proximal-disease-extension-and-colectomy-in-left-sided-ulcerative-colitis
#7
S Sahami, K Konté, C J Buskens, P J Tanis, M Löwenberg, C J Ponsioen, G R van den Brink, W A Bemelman, G R D'Haens
OBJECTIVE: The primary objective of this study was to assess proximal disease extension of ulcerative colitis (UC) over time, with disease behaviour pattern and risk factors for proximal disease extension and colectomy as secondary aims. METHODS: All cumulative incident cases diagnosed with UC at the Academic Medical Center between January 1990 and December 2009 were studied. The cumulative risk of colectomy was calculated by Kaplan-Meier analysis. The Cox proportional hazards regression was used to identify risk factors associated with proximal disease extension and colectomy...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588886/laparoscopic-versus-open-appendectomy-in-adults-and-children-a-meta-analysis-of-randomized-controlled-trials
#8
Liping Dai, Jian Shuai
OBJECTIVE: The aim of this study was to evaluate the differences of laparoscopic appendectomy (LA) versus open appendectomy (OA) in adults and children. METHODS: Randomized controlled trials (RCTs) comparing LA and OA in adults and children between January 1992-March 2016 were included in this study. A meta-analysis was performed to evaluate wound infection, intra-abdominal abscess, postoperative complications, reoperation rate, operation time, postoperative stay, and return to normal activity...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588885/elevated-trimethylamine-n-oxide-tmao-is-associated-with-poor-prognosis-in-primary-sclerosing-cholangitis-patients-with-normal-liver-function
#9
Martin Kummen, Mette Vesterhus, Marius Trøseid, Bjørn Moum, Asbjørn Svardal, Kirsten Muri Boberg, Pål Aukrust, Tom Hemming Karlsen, Rolf Kristian Berge, Johannes Roksund Hov
BACKGROUND: Trimethylamine-N-oxide (TMAO) is produced in the liver from trimethylamine, which is exclusively generated by gut bacteria. OBJECTIVE: The objective of this article is to investigate the relationship between TMAO and primary sclerosing cholangitis (PSC) and its clinical characteristics. METHODS: Serum TMAO was measured in 305 PSC patients, 90 ulcerative colitis patients and 99 healthy controls. RESULTS: In PSC patients with normal liver function (n = 197), TMAO was higher in patients reaching liver transplantation or death during follow-up than those who did not, with an optimal TMAO cut-off of 4...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588884/distinctive-hla-ii-association-with-primary-biliary-cholangitis-on-the-island-of-sardinia
#10
Maria Grazia Clemente, Fulvia Frau, Matilde Bernasconi, Maria Doloretta Macis, Lucia Cicotto, Giampaolo Pilleri, Stefano De Virgiliis, Paolo Castiglia, Patrizia Farci
BACKGROUND: The HLA DRB1*08 allele associated with primary biliary cholangitis (PBC) among Caucasians is of low frequency in the Sardinian population. OBJECTIVE: The aim of our study was to type a cohort of PBC patients from the island of Sardinia for HLA class II antigens. METHODS: Twenty Sardinian patients affected by PBC, 14 with autoimmune hepatitis (AIH) and 89 healthy controls (HCs) were typed for HLA class II alleles by dot-blot analysis...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588883/compliance-with-evidence-based-multidisciplinary-guidelines-on-perihilar-cholangiocarcinoma
#11
Robert Js Coelen, Joost Huiskens, Pim B Olthof, Eva Roos, Jimme K Wiggers, Annuska Schoorlemmer, Otto M van Delden, Heinz-Josef Klümpen, Erik Aj Rauws, Thomas M van Gulik
BACKGROUND: Discrepancies are often noted between management of perihilar cholangiocarcinoma (PHC) in regional hospitals and the eventual treatment plan in specialized centers. OBJECTIVE: The objective of this article is to evaluate whether regional centers adhere to guideline recommendations following implementation in 2013. METHODS: Data were analyzed from all consecutive patients with suspected PHC referred to our academic center between June 2013 and December 2015...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588882/transarterial-chemoembolization-vs-bland-embolization-in-hepatocellular-carcinoma-a-meta-analysis-of-randomized-trials
#12
Antonio Facciorusso, Francesco Bellanti, Rosanna Villani, Veronica Salvatore, Nicola Muscatiello, Fabio Piscaglia, Gianluigi Vendemiale, Gaetano Serviddio
BACKGROUND: Although transarterial chemoembolization is considered the standard of care for intermediate hepatocellular carcinoma patients, robust data in favor of a clear superiority of chemoembolization (with chemotherapy injection) over bland embolization are lacking. OBJECTIVE: The objective of this article is to systematically analyze the results provided by randomized controlled trials comparing these two treatments in hepatocarcinoma patients. METHODS: A computerized bibliographic search on the main databases was performed...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588881/endoscopic-classification-of-the-papilla-of-vater-results-of-an-inter-and-intraobserver-agreement-study
#13
E Haraldsson, L Lundell, F Swahn, L Enochsson, J M Löhr, U Arnelo
BACKGROUND: Many endoscopists acknowledge that the appearance of the papilla of Vater seems to affect biliary cannulation. To assess the association between the macroscopic appearance of the papilla and biliary cannulation and other related clinical issues, a system is needed to define the appearance of the papilla. OBJECTIVE: The purpose of this study was to validate an endoscopic classification of the papilla of Vater by assessing the interobserver and intraobserver agreements among endoscopist with varying experience...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588880/estimation-of-the-prevalence-of-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-in-the-french-population-through-patients-waiting-for-liver-transplantation
#14
Lucie Laurent, Marie-Pierre Vullierme, Vinciane Rebours, Frédérique Maire, Olivia Hentic, Claire Francoz, François Durand, Philippe Ruszniewski, Philippe Lévy
BACKGROUND AND AIMS: Some studies have explored the prevalence of pancreatic cystic lesions (PCLs). Only one study based on magnetic resonance imaging (MRI) report examination focused specifically on intraductal papillary mucinous neoplasm (IPMN) in a European general population. The aim of this study was to evaluate the prevalence of IPMN in a population of patients who had MRI for a non-pancreatic disease. METHODS: We conducted a retrospective, single-center study...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588879/an-international-multicenter-study-of-early-intravenous-fluid-administration-and-outcome-in-acute-pancreatitis
#15
Vikesh K Singh, Timothy B Gardner, Georgios I Papachristou, Mónica Rey-Riveiro, Mahya Faghih, Efstratios Koutroumpakis, Elham Afghani, Nelly G Acevedo-Piedra, Nikhil Seth, Amitasha Sinha, Noé Quesada-Vázquez, Neftalí Moya-Hoyo, Claudia Sánchez-Marin, Juan Martínez, Félix Lluís, David C Whitcomb, Pedro Zapater, Enrique de-Madaria
AIMS: Early aggressive fluid resuscitation in acute pancreatitis is frequently recommended but its benefits remain unproven. The aim of this study was to determine the outcomes associated with early fluid volume administration in the emergency room (FVER) in patients with acute pancreatitis. METHODS: A four-center retrospective cohort study of 1010 patients with acute pancreatitis was conducted. FVER was defined as any fluid administered from the time of arrival to the emergency room to 4 h after diagnosis of acute pancreatitis, and was divided into tertiles: nonaggressive (<500 ml), moderate (500 to 1000 ml), and aggressive (>1000 ml)...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588878/a-novel-purgative-protocol-for-capsule-endoscopy-of-the-small-bowel-produces-better-quality-of-visibility-than-2%C3%A2-l-of-peg-timing-is-of-the-essence
#16
Samuel N Adler, Shai Farkash, Yishai Sompolinsky, Inna Gafanovich, Eran Goldin, Ariella Bar-Gil Shitrit
INTRODUCTION: The ideal way of preparing patients for small-bowel capsule endoscopy has been controversial. Previous studies have shown that ingestion of 2 l of polyethylenglycol (PEG) 12 hours prior to capsule ingestion leads to improved visibility in comparison to no preparation at all. We speculated that using a post-ingestion (PI), booster-based cleansing protocol might provide an alternative to the PEG cleansing protocol. METHODS: This randomized, blinded, prospective study enrolled 45 individuals...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588877/endoscopic-removal-of-over-the-scope-clips-clinical-experience-with-a-bipolar-cutting-device
#17
Markus Bauder, Benjamin Meier, Karel Caca, Arthur Schmidt
BACKGROUND: Over-the-scope clips (OTSCs) are increasingly used for the closure of perforations/fistulae, hemostasis and endoscopic full-thickness resection (FTRD system). When OTSC-associated complications occur or re-therapy at the OTSC site is needed, OTSC removal may be indicated. An experimental study in an animal model and a case series have shown good results for OTSC removal with a bipolar cutting device. We present a larger clinical study using this device. METHODS: Data of all consecutive patients with indication for OTSC removal were collected and analyzed retrospectively...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588876/increased-risk-for-metachronous-gastric-adenocarcinoma-following-gastric-malt-lymphoma-a-us-population-based-study
#18
Carolina Palmela, Cristina Fonseca, Rita Faria, Rute Baeta Baptista, Sofia Ribeiro, Alexandre Oliveira Ferreira
BACKGROUND: Gastric mucosa-associated lymphoid tissue lymphoma (gMALT) and gastric adenocarcinoma (GC) are long-term complications of chronic Helicobacter pylori (HP) gastritis. Treatment of HP infection induces remission in most patients with gMALT. Endoscopic follow-up is not currently endorsed after complete remission. However, the risk of GC in these patients is unclear. OBJECTIVE: The objective of this study is to estimate GC risk in gMALT patients. METHODS: The National Cancer Institute Surveillance, Epidemiology and End Results 13 (SEER) database-Nov 2014 Sub (1992-2012) was used to identify adult patients diagnosed with gMALT between 1992 and 2012...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28588875/management-of-chronic-constipation-in-adults
#19
REVIEW
K Krogh, G Chiarioni, W Whitehead
Chronic constipation (CC) is an extremely common condition with an estimated prevalence of up to 24%. Most patients with CC should be treated in primary care. Changes in lifestyle, including increased intake of dietary fibre, fluid, and exercise, should be attempted in most patients. Osmotic or stimulant laxatives are indicated if there are insufficient effects of lifestyle changes. Prokinetics and secretagogues should be restricted to those not responding to basic treatment. Anorectal physiology tests and assessment of colorectal transit time are indicated if medical treatment fails or if symptoms indicate severely obstructed defecation...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28507761/the-european-section-and-board-of-gastroenterology-and-hepatology
#20
Isabelle Cremers, Ian Barrison, Jan Lillienau, Jean-Paul Jacques
No abstract text is available yet for this article.
April 2017: United European Gastroenterology Journal
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