Maria Wiese, Bente Pohlmeier, Klaudia Kubiak, Fatma E El-Khouly, Maren Sitte, Angel M Carcaboso, Joshua N Baugh, Thomas Perwein, Gunther Nussbaumer, Michael Karremann, Gerrit H Gielen, Gabriela Salinas, Christof M Kramm
BACKGROUND AND AIM: Pediatric high-grade gliomas (pedHGG) comprise a very poor prognosis. Thus, parents of affected children are increasingly resorting to complementary and alternative medicine (CAM), among those Boswellia extracts. However, nothing is known about the therapeutic effectiveness of their active substances, Boswellic acids (BA) in pedHGG. Thus, we aimed to investigate if the three main Boswellic acids (BA) present in Boswellia plants, alpha-boswellic acid (α-BA), beta-boswellic acid (β-BA) and 3-acetyl-11-keto-beta-boswellic acid (AKBA) hold any promising potential for treatment of affected pedHGG patients...
January 2024: Journal of Traditional and Complementary Medicine