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Journal of Bone Metabolism

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https://www.readbyqxmd.com/read/27965946/prevalence-of-sarcopenia-adjusted-body-mass-index-in-the-korean-woman-based-on-the-korean-national-health-and-nutritional-examination-surveys
#1
Hyoung-Moo Park, Yong-Chan Ha, Jun-Il Yoo, Hyun-Jun Ryu
BACKGROUND: The purpose of this study was to determine cut-off point of appendicular skeletal muscle mass (ASM) adjusted body mass index (BMI) for sarcopenia in the Korean women and evaluate the prevalence of sarcopenia in postmenopausal women. METHODS: This study was based on the data obtained from 2008 to 2011 Korean National Health and Nutrition Examination Survey (KNHANES) IV and V. A whole body dual energy X-ray absorptiometry (DXA) scan and measurement of BMI were performed on individuals of ≥10 years old...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27965945/replication-of-caucasian-loci-associated-with-osteoporosis-related-traits-in-east-asians
#2
Beom-Jun Kim, Seong Hee Ahn, Hyeon-Mok Kim, Shiro Ikegawa, Tie-Lin Yang, Yan Guo, Hong-Wen Deng, Jung-Min Koh, Seung Hun Lee
BACKGROUND: Most reported genome-wide association studies (GWAS) seeking to identify the loci of osteoporosis-related traits have involved Caucasian populations. We aimed to identify the single nucleotide polymorphisms (SNPs) of osteoporosis-related traits among East Asian populations from the bone mineral density (BMD)-related loci of an earlier GWAS meta-analysis. METHODS: A total of 95 SNPs, identified at the discovery stage of the largest GWAS meta-analysis of BMD, were tested to determine associations with osteoporosis-related traits (BMD, osteoporosis, or fracture) in Korean subjects (n=1,269)...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27965944/relationship-between-heavy-metal-exposure-and-bone-mineral-density-in-korean-adult
#3
Hee-Sook Lim, Hae-Hyeog Lee, Tae-Hee Kim, Bo-Ra Lee
BACKGROUND: Exposure to heavy metals from environmental and industrial sources remains a concern of serious public health risk. This study was conducted to analysis the relationship between heavy metal concentrations and bone density. METHODS: This study used data from a nation-based sample of Koreans (n=2,429) from 2008 to 2011 Korea National Health and Nutrition Examination Survey. We were obtained heavy metals (lead, mercury and cadmium), socioeconomic and demographic factors and bone mineral density (BMD) measured by T-score...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27965943/bone-mineral-density-and-fatty-degeneration-of-thigh-muscles-measured-by-computed-tomography-in-hip-fracture-patients
#4
Myung Hoon Hahn, Ye-Yeon Won
BACKGROUND: Recently, as an independent fracture factor from Bone mineral density (BMD), muscle weakness due to the fatty degeneration of thigh muscles have been attracting attentions as causes of hip fracture. The purpose of this study is to investigate the correlation between the body composition and BMD and fatty degeneration of thigh muscles of the female patients over 65 years old with osteoporotic hip fracture. METHODS: This study was conducted with 178 female osteoporotic hip fracture patients...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27965942/attenuation-of-rankl-induced-osteoclast-formation-via-p38-mediated-nfatc1-signaling-pathways-by-extract-of-euphorbia-lathyris-l
#5
Ju-Hee Kang, Hyojung Lim, Ji-Eun Jeong, Mijung Yim
BACKGROUND: Osteoclasts are the only cell type capable of breaking down bone matrix, and its excessive activation is responsible for the development of bone-destructive diseases. Euphorbia lathyris L. (ELL) is an herbal plant that belongs to the Euphorbiaceae family. This study investigated the effects of the methanol extract of the aerial part of ELL on receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclast formation and signaling pathways. METHODS: Osteoclasts were formed by co-culturing mouse bone marrow with osteoblasts or by culturing mouse bone marrow-derived macrophages (BMMs) with macrophage colony-stimulating factor (M-CSF) and RANKL...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27965941/health-related-quality-of-life-in-accordance-with-fracture-history-and-comorbidities-in-korean-patients-with-osteoporosis
#6
Hye-Young Kwon, Yong-Chan Ha, Jun-Il Yoo
BACKGROUND: The purpose of this study was to explore health-related quality of life (HRQOL) among Korean patients with osteoporosis and to measure the impact of fractures and comorbidity on their quality of life (QOL) using the Korean National Health and Nutrition Examination Survey (KNHANES) data with a nationwide representativeness. METHODS: This study was based on 4-year-data obtained from the KNHANES 2008 to 2011. Osteoporosis was diagnosed in 2,078 survey participants according to their bone mineral density measurements using dual energy X-ray absorptiometry...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27965940/coronary-calcification-is-reversely-related-with-bone-and-hair-calcium-the-relationship-among-different-calcium-pools-in-body
#7
Sang-Hoon Lee, Soo-Jung Park, Kyu-Nam Kim, Doo-Yeoun Cho, Young-Sang Kim, Bom-Taeck Kim
BACKGROUND: With aging, calcium efflux from bone is increased with age-related bone loss, and it can reduce bone mineral density (BMD). On the contrary, age-related calcium adoption into arterial wall progressively stiffens blood vessels. Theses process insinuates shift of calcium among different pools in body. However, their relationships have not been elucidated yet. So we investigated the correlation among calcium contents in different body pools, such as hair, bone, and blood vessels in women...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27965939/association-of-serum-osteocalcin-with-insulin-resistance-and-coronary-atherosclerosis
#8
Jee-Hyun Kang
BACKGROUND: To determine the associations between serum osteocalcin level and insulin resistance, coronary atherosclerosis by using dual-source coronary computed tomography angiography. METHODS: A total of 98 subjects (24 men and 74 women) were selected for this retrospective cross-sectional study who voluntarily visited a health examination center for routine health check-up including the blood test for serum osteocalcin level and coronary computed tomography angiography...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622182/proximal-femoral-geometry-as-fracture-risk-factor-in-female-patients-with-osteoporotic-hip-fracture
#9
Jun Han, Myung Hoon Hahn
BACKGROUND: Proximal femoral geometry may be a risk factor of osteoporotic hip fractures. However, there existed great differences among studies depending on race, sex and age of subjects. The purpose of the present study is to analyze proximal femoral geometry and bone mineral density (BMD) in the osteoporotic hip fracture patients. Furthermore, we investigated proximal femoral geometric parameters affecting fractures, and whether the geometric parameters could be an independent risk factor of fractures regardless of BMD...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622181/pamidronate-down-regulates-tumor-necrosis-factor-alpha-induced-matrix-metalloproteinases-expression-in-human-intervertebral-disc-cells
#10
Young-Mi Kang, Seong-Hwan Hong, Jae-Ho Yang, Jin-Cheol Oh, Jin-Oh Park, Byung Ho Lee, Sang-Yoon Lee, Hak-Sun Kim, Hwan-Mo Lee, Seong-Hwan Moon
BACKGROUND: N-containing bisphosphonates (BPs), such as pamidronate and risedronate, can inhibit osteoclastic function and reduce osteoclast number by inducing apoptotic cell death in osteoclasts. The aim of this study is to demonstrate the effect of pamidronate, second generation nitrogen-containing BPs and to elucidate matrix metallo-proteinases (MMPs) mRNA expression under serum starvation and/or tumor necrosis factor alpha (TNF-α) stimulation on metabolism of intervertebral disc (IVD) cells in vitro...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622180/the-influence-of-the-type-of-continuous-exercise-stress-applied-during-growth-periods-on-bone-metabolism-and-osteogenesis
#11
Sangun Lee, Takao Suzuki, Hiromi Izawa, Atsuko Satoh
BACKGROUND: In this study, we examined the influence of exercise loading characteristics on bone metabolic responses and bone morphology in the growth phase and adulthood. METHODS: Running exercise (RUN) and jumping exercise (JUM) were used for the exercise loading in 28-day-old male Wistar rats. Bone metabolism was measured by blood osteocalcin (OC) and tartrate-resistant acid phosphatase (TRACP) levels. For bone morphology, the maximum bone length, bone weight, and bone strength of the femur and tibia were measured...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622179/prolonged-practice-of-swimming-is-negatively-related-to-bone-mineral-density-gains-in-adolescents
#12
Marcelo R Ribeiro-Dos-Santos, Kyle R Lynch, Ricardo R Agostinete, Santiago Maillane-Vanegas, Bruna Turi-Lynch, Igor H Ito, Rafael Luiz-de-Marco, Mario A Rodrigues-Junior, Rômulo A Fernandes
BACKGROUND: The practice of swimming in "hypogravity" conditions has potential to decrease bone formation because it decreases the time engaged in weight-bearing activities usually observed in the daily activities of adolescents. Therefore, adolescents competing in national levels would be more exposed to these deleterious effects, because they are engaged in long routines of training during most part of the year. To analyze the effect of swimming on bone mineral density (BMD) gain among adolescents engaged in national level competitions during a 9-month period...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622178/comparison-in-adherence-to-osteoporosis-guidelines-according-to-bone-health-status-in-korean-adult
#13
Hee-Sook Lim, Soon-Kyung Kim, Hae-Hyeog Lee, Dong Won Byun, Yoon-Hyung Park, Tae-Hee Kim
BACKGROUND: Osteoporosis one of the most serious disease to decrease the quality of life and cause economic loss. Thus, prevention of osteoporosis has become an important health concern. The study examined in adherence to osteoporosis guidelines and compared the levels of adherence to osteoporosis guidelines between bone health status in Korean adult. METHODS: This study used data from a nationally represented sample of Koreans (n=3,419) from 2008 to 2011 Korea National Health and Nutrition Examination Survey...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622177/an-experimental-study-for-minimum-level-of-decalcification-to-detect-the-osteolytic-bone-metastasis-of-long-bone-on-plain-radiography
#14
Jun Ho Baek, Il Hyung Park, Sung Hwa Seo
BACKGROUND: In 1951, Ardran reported that metastatic bone lesions could be detectable on plain radiography with 30% to 50% of decalcification. Authors performed experimental study for minimum level of decalcification to detect the osteolytic bone metastasis of long bone with recent technique of radiographs. METHODS: One pair of fibula and humerus from two cadavers was cut into specimen 1 inch in length. Distal half of specimen was dipped into hydrochloride (HCl) with 15 min interval...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622176/association-between-homocysteine-and-bone-mineral-density-according-to-age-and-sex-in-healthy-adults
#15
Joo Il Kim, Ji Hyun Moon, Hye Won Chung, Mi Hee Kong, Hyeon Ju Kim
BACKGROUND: There are several studies about the relationship between serum homocysteine levels and bone mineral density (BMD), but the results are varied, and the studies are limited in Korea. In our study, the relationship between serum homocysteine levels and BMD by part according to age and sex is investigated. METHODS: From March 2012 to July 2015, the 3,337 healthy adults who took a medical examination were recruited. Subjects filled in the self-recording type questionnaire and physical examination, blood test, BMD of lumbar spine and femur were measured...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622175/current-status-and-strategy-of-microrna-research-for-cartilage-development-and-osteoarthritis-pathogenesis
#16
REVIEW
Hiroshi Asahara
MicroRNAs (miRNAs), which are small (~21 nucleotides) non-coding RNAs, are important players in endochondral ossification, articular cartilage homeostasis, and arthritis pathogenesis. Comprehensive and genetic analyses of cartilage-specific or cartilage-related miRNAs have provided new information on cartilage development, homeostasis, and related diseases. State-of-the-art combinatorial approaches, including transcription-activator like effector nuclease (TALEN)/clustered regularly interspaced short palindromic repeats (CRISPR) technique for targeting miRNAs and high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation for identifying target messenger RNAs, should be used to determine complex miRNA networks and miRNA-dependent cartilage regulation...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27622174/osteoporosis-associated-with-chronic-obstructive-pulmonary-disease
#17
REVIEW
Ryo Okazaki, Reiko Watanabe, Daisuke Inoue
Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27294082/high-levels-of-heavy-metals-increase-the-prevalence-of-sarcopenia-in-the-elderly-population
#18
Jun-Il Yoo, Yong-Chan Ha, Young-Kyun Lee, Kyung-Hoi Koo
BACKGROUND: Despite increasing concern regarding health problems as a result of environmental pollutants, no association of toxic heavy metals with sarcopenia has been demonstrated in the general population. We investigated the association of heavy metals, including lead, mercury and cadmium, with sarcopenia in the Korean population. METHODS: Participants included 344 males and 360 females older than 65 years based on data from the fourth and fifth Korea National Health and Nutritional Examination Surveys...
May 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27294081/the-association-between-muscle-mass-deficits-estimated-from-bioelectrical-impedance-analysis-and-lumbar-spine-bone-mineral-density-in-korean-adults
#19
Hye-Yeon Jang, Hee-Jeong Choi, Kye-Bong Lee, Sul-Bit Cho, In Jae Im, Hee Jin Kim
BACKGROUND: Bone mineral density (BMD) is influenced by many factors. Despite the reported association between body components and BMD, most of these studies investigated the relationship between absolute muscle mass or fat mass and BMD in postmenopausal women or elderly subjects. The aim of this study is to investigate the association between muscle mass deficits (MMD) estimated from bioelectrical impedance analysis (BIA) and lumbar spinal BMD in Korean adults 20 to 49 years of age. METHODS: This cross-sectional study included 1,765 men and women who visited a health promotion center for a routine checkup...
May 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27294080/difference-in-bone-mineral-density-change-at-the-lateral-femoral-cortices-according-to-administration-of-different-bisphosphonate-agents
#20
Sungjun Kim, Hyun Hee Bang, Hanna Yoo, Il Hyung Park, Kyu Hyun Yang, Hyunsun Lim, Woo Seok Jung
BACKGROUND: To retrospectively assess whether the response of subtrochanteric lateral cortex (STLC) is different according to the bisphosphonate agents in terms of bone mineral density (BMD) change. METHODS: A total of 149 subjects, who had 2- to 4-year interval follow-up of BMD using dual energy X-ray absorptiometry (DXA), were included in this retrospective study divided into following 3 groups: control group (no consumption of any anti-osteoporotic drugs, n=38), alendronate group (naïve alendronate users, n=48), risedronate group (naïve risedronate users, n=63)...
May 2016: Journal of Bone Metabolism
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