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Journal of Bone Metabolism

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https://www.readbyqxmd.com/read/29900162/association-of-insulin-resistance-with-lower-bone-volume-and-strength-index-of-the-proximal-femur-in-nondiabetic-postmenopausal-women
#1
Jaewon Yang, Namki Hong, Jee-Seon Shim, Yumie Rhee, Hyeon Chang Kim
Background: Type 2 diabetes mellitus is associated with an increased risk of osteoporotic fracture despite relatively preserved bone mineral density (BMD). Although this paradox might be attributed to the influence of insulin resistance (IR) on bone structure and material properties, the association of IR with femur bone geometry and strength indices remains unclear. Methods: Using data from the Cardiovascular and Metabolic Disease Etiology Research Center cohort study, we conducted a cross-sectional analysis among nondiabetic postmenopausal women...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900161/the-impact-of-educational-interventions-on-osteoporosis-knowledge-among-korean-osteoporosis-patients
#2
Won Seok Jo, Eun Hee Cho, Beon Jung Kang, Gi Du Kwon, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
Background: The purpose of this study was to determine the impact of an educational intervention that includes information sharing about absolute fracture risk on the knowledge of osteoporosis and modifiable risk factors among Korean patients with osteoporosis. Methods: Adults aged >50 years who visited the outpatient clinic for osteoporosis were recruited. Subjects with trauma-related fractures or pathological fractures were excluded. The anthropometric data and clinical risk factors for fracture were collected at baseline...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900160/improvement-of-osteoporosis-medication-after-multimodal-intervention-in-patients-with-hip-fracture-prospective-multicenter-study
#3
Yong-Geun Park, Kwang Woo Nam, Sang-Rim Kim, Min-Suk Park, Sang-Jae Kim, Yong-Chan Ha
Background: The authors had earlier conducted a retrospective cohort study from 2008 to 2011 in Jeju Island, among 945 hip fracture patients above 50 years of age. Of these 945 patients, 344 patients (36.4%) underwent a bone mineral density test and 218 patients (23.1%) received treatment for osteoporosis. The purpose of this study was to determine whether a patient education program could improve osteoporosis management after hip fracture. The data of the previous study was used for comparison...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900159/is-sarcopenia-a-potential-risk-factor-for-distal-radius-fracture-analysis-using-propensity-score-matching
#4
Jun-Ku Lee, Byung-Ho Yoon, Chi Hoon Oh, Jung Gon Kim, Soo-Hong Han
Background: Cases of low-energy-induced distal radius fracture (DRF) are increasing. Sarcopenia is considered to be an independent risk factor for fragility fractures. We compared body appendicular lean muscle mass (ALM) and bone mineral density (BMD) in patients with DRF and a comparable control population. This study aimed to investigate the correlation between skeletal muscle mass and DRF. Methods: We performed a retrospective review of patients diagnosed with fragility DRF...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900158/high-plasma-sphingosine-1-phosphate-levels-predict-osteoporotic-fractures-in-postmenopausal-women-the-center-of-excellence-for-osteoporosis-research-study
#5
Mohammed-Salleh M Ardawi, Abdulrahim A Rouzi, Nawal S Al-Senani, Mohammed H Qari, Ayman Z Elsamanoudy, Shaker A Mousa
Background: Higher sphingosine 1-phosphate (S1P) plasma levels are associated with decreased bone mineral density (BMD), and increased risk of prevalent vertebral fracture. So, we hypothesized that postmenopausal women with increased baseline plasma S1P levels have a greater risk for future incident fracture (osteoporosis-related fractures [ORFs]). Methods: This study was conducted in a prospective longitudinal cohort of 707 women recruited in 2004 and followed up annually for a mean period of 5...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900157/agreement-between-the-turkey-guidelines-and-the-fracture-risk-assessment-tool%C3%A2-based-intervention-threshold
#6
Ahmet Imerci, Nevres Hurriyet Aydogan, Kursad Tosun
Background: The aim of this study was to evaluate the agreement between the fracture-risk assessment tool (FRAX®)-based intervention strategy in Turkey and the recommendations published in the Healthcare Practices Statement (HPS). Methods: This descriptive cross-sectional study included individuals aged 40 to 90 years who were previously diagnosed as having osteoporosis but had not received any treatment. The intervention thresholds recommended by the National Osteoporosis Foundation for treatment were used...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900156/clinical-utility-of-biochemical-marker-of-bone-turnover-fracture-risk-prediction-and-bone-healing
#7
REVIEW
Byung-Ho Yoon, Woojin Yu
Bone turnover markers (BTMs) are released during bone remodeling and are thought to reflect the metabolic activity of bone at the cellular level. This review examines BTM as a biological response marker for monitoring future fracture prediction and fracture healing processes. Substantial evidence has been of high value to investigate the use of BTM in fracture risk prediction; nevertheless, the conclusions of some studies are inconsistent due to their large variability. BTM is promising for fracture risk prediction for adopting international reference standards or providing absolute risks, such as 10-year fracture probabilities...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900155/differential-role-of-transforming-growth-factor-beta-in-an-osteoarthritic-or-a-healthy-joint
#8
REVIEW
Peter M van der Kraan
Transforming growth factor-β (TGF-β) is a cytokine that plays an important role in both normal joints and joints affected by osteoarthritis (OA), the most common joint disease. However, the role of this pleiotropic cytokine in a normal healthy joint is very different from its role in an OA joint. In a normal synovial joint, active TGF-β is only present after joint loading and only for a short period. In contrast, permanent and high levels of active TGF-β are detected in OA joints. Due to this difference in levels and exposure period of joint cells to active TGF-β, the function of TGF-β is strikingly different in normal and OA joints...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564307/prevalence-and-associated-risk-factors-of-sarcopenia-in-female-patients-with-osteoporotic-fracture
#9
Byung-Ho Yoon, Jun-Ku Lee, Dae-Sung Choi, Soo-Hong Han
Background: We determined the prevalence of sarcopenia according to fracture site and evaluated the associated risk factors in female patients with osteoporotic fractures. Methods: A total of 108 patients aged 50 years or older with an osteoporotic fracture (hip, spine, or wrist) were enrolled in this retrospective observational study. A diagnosis of sarcopenia was confirmed using whole-body densitometry for skeletal muscle mass measurement. Logistic regression analysis was used to analyze the risk factors for sarcopenia...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564306/sarcopenic-obesity-in-elderly-korean-women-a-nationwide-cross-sectional-study
#10
Young Nam Kwon, Sung Sang Yoon, Kyung-Hag Lee
Background: Sarcopenia causes loss of muscle mass in the elderly and is associated with development of metabolic syndrome in those with obesity. This study evaluated the prevalence of sarcopenic obesity (SO) in healthy Korean elderly women. Methods: This study was based on data from the Korea National Health and Nutrition Examination Survey IV and V, 2008-2011. Whole body dual energy X-ray absorptiometry and body mass index measurement were performed for all patients...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564305/the-effect-of-antidepressants-on-mesenchymal-stem-cell-differentiation
#11
Jeffrey S Kruk, Sandra Bermeo, Kristen K Skarratt, Stephen J Fuller, Gustavo Duque
Background: Use of antidepressant medications has been linked to detrimental impacts on bone mineral density and osteoporosis; however, the cellular basis behind these observations remains poorly understood. The effect does not appear to be homogeneous across the whole class of drugs and may be linked to affinity for the serotonin transporter system. In this study, we hypothesized that antidepressants have a class- and dose-dependent effect on mesenchymal stem cell (MSC) differentiation, which may affect bone metabolism...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564304/track-and-field-practice-and-bone-outcomes-among-adolescents-a-pilot-study-abcd-growth-study
#12
Yuri da Silva Ventura Faustino-da-Silva, Ricardo Ribeiro Agostinete, André Oliveira Werneck, Santiago Maillane-Vanegas, Kyle Robinson Lynch, Isabella Neto Exupério, Igor Hideki Ito, Romulo Araújo Fernandes
Background: Osteoporosis is considered a public health problem with high worldwide prevalence. One approach to prevention is through the promotion of physical activity, especially exercise, during adolescence. Methods: This study compared bone variables in different body segments in adolescents according to participation in track and field. The study included 34 adolescents (22 boys), of whom 17 were track and field athletes and 17 were control subjects. Bone mineral density (BMD, g/cm2 ) and bone mineral content (BMC, g) were analyzed using dual energy X-ray absorptiometry (total body stratified by body segments)...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564303/%C3%AE-tocopheryl-succinate-inhibits-osteolytic-bone-metastasis-of-breast-cancer-by-suppressing-migration-of-cancer-cells-and-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-expression-of-osteoblasts
#13
Bongjun Kim, Hong-Hee Kim, Zang Hee Lee
Background: Breast cancer is one of the most common cancers affecting women and has a high incidence of bone metastasis, causing osteolytic lesions. The elevated expression of receptor activator of nuclear factor-κB ligand (RANKL) in cancer activates osteoclasts, leading to bone destruction. We previously reported that α-tocopheryl succinate (αTP-suc) inhibited interleukin-1-induced RANKL expression in osteoblasts. Here, we examined the effect of αTP-suc on osteolytic bone metastasis in breast cancer...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564302/new-skeletal-muscle-mass-index-in-diagnosis-of-sarcopenia
#14
Jeong Jae Moon, Sam-Guk Park, Seung Min Ryu, Chan-Ho Park
Background: We sought to develop a novel index based on the skeletal muscle mass that reflects the change of quality of life (QOL), and is the most appropriate index for the body composition of the elderly in Korea. Whether lower extremity skeletal muscle mass index (LESMI) is an appropriate novel new index to diagnose patients with sarcopenia was also evaluated. A cut-off value for each index was reported to facilitate the diagnosis of patients with sarcopenia in a Korean population...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564301/trans-differentiation-via-epigenetics-a-new-paradigm-in-the-bone-regeneration
#15
REVIEW
Young-Dan Cho, Hyun-Mo Ryoo
In regenerative medicine, growing cells or tissues in the laboratory is necessary when damaged cells can not heal by themselves. Acquisition of the required cells from the patient's own cells or tissues is an ideal option without additive side effects. In this context, cell reprogramming methods, including the use of induced pluripotent stem cells (iPSCs) and trans-differentiation, have been widely studied in regenerative research. Both approaches have advantages and disadvantages, and the possibility of de-differentiation because of the epigenetic memory of iPSCs has strengthened the need for controlling the epigenetic background for successful cell reprogramming...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564300/review-of-epidemiology-diagnosis-and-treatment-of-osteosarcopenia-in-korea
#16
REVIEW
Jun-Il Yoo, Yong-Chan Ha
Sarcopenia was listed in the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) as M62.84, on October 1, 2016. Sarcopenia is primarily associated with metabolic diseases, such as diabetes, obesity, and cachexia, as well as chronic renal failure, congestive heart failure, and chronic obstructive pulmonary disease. Sarcopenia is also significantly associated with osteoporosis in elderly populations and the combined disease is defined as osteosarcopenia. Several studies have confirmed that sarcopenia and osteoporosis (osteosarcopenia) share common risk factors and biological pathways...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259966/x-linked-hypophosphatemic-rickets-del-2-q37-1-q37-3-deletion-syndrome-and-mosaic-turner-syndrome-mos-45-x-46-x-del-2-q37-1-q37-3-in-a-3-year-old-female
#17
Alaina P Vidmar, Brian Miyazaki, Pedro A Sanchez-Lara, Pisit Pitukcheewanont
There are currently no published cases that report concomitant Turner syndrome (TS), 2q37 deletion syndrome and X-linked hypophosphatemic rickets (XLH). Interestingly, since the clinical phenotypes of TS and 2q37 deletion syndrome overlap, the correct diagnosis may be missed without a standardized approach to genetic testing consisting of both karyotype and microarray. Both chromosome anomalies have been associated with short stature and a variety of skeletal abnormalities however to date no reports have associated these syndromes in association with a phosphate regulating endopeptidase homolog, X-linked ( PHEX ) gene deletion resulting in XLH...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259965/clinical-characteristics-causes-and-survival-in-115-cancer-patients-with-parathyroid-hormone-related-protein-mediated-hypercalcemia
#18
Joon Jin, Jin Ook Chung, Min Young Chung, Dong Hyeok Cho, Dong Jin Chung
Background: The aim of this study is to determine the proportion of cancers presenting with parathyroid hormone (PTH) related protein (PTHrP)-mediated hypercalcemia, examine the clinical and biochemical characteristics, identify predictive factors for survival. And we also compared those characteristics between solid organ and hematologic malignancy groups. Methods: Cancer patients with PTHrP-mediated hypercalcemia who were treated at Chonnam National University Hospital in Korea from January 2005 to January 2015 were retrospectively reviewed...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259964/prevalence-of-osteoporosis-in-korean-patients-with-chronic-obstructive-pulmonary-disease-and-their-health-related-quality-of-life-according-to-the-korea-national-health-and-nutrition-examination-survey-2008-2011
#19
Sang Hee Lee, Hye-Young Kwon
Background: In this study, we evaluated the prevalence of osteoporosis, risk factors associated with osteoporosis, and health-related quality of life (HRQOL) in clinically stable chronic obstructive pulmonary disease (COPD) patients. Methods: A total of 1,081 COPD patients were recruited from the Korea National Health and Nutrition Examination Survey (KNHANES) from July 2008 to May 2011. Bone mineral densities at the lumbar spine, femoral neck, and total proximal femur were measured using dual energy X-ray absorptiometry...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259963/comparison-of-bone-mineral-density-and-appendicular-lean-body-mass-between-osteoporotic-distal-radius-fracture-and-degenerative-rotator-cuff-tear-in-women-patients
#20
Jun-Ku Lee, Byung-Ho Yoon, Kyunghun Jung, Gotak Kim, Soo-Hong Han
Background: Authors assessed lean body mass (fat free tissue), upper and lower, and bone mineral density (BMD) in patients of osteoporotic bone distal radius fracture (DRF) and degenerative rotator cuff tear (RCT) patients of shoulder. We predict inferior muscle mass and osteoporosis are more frequent in DRF group than RCT group. Methods: Between January 2016 and June 2017, overall 38 of DRF and 30 of RCT were eligible for this retrospective comparison study after excluding of patients with compounding factors...
November 2017: Journal of Bone Metabolism
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