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Journal of Bone Metabolism

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https://www.readbyqxmd.com/read/29564307/prevalence-and-associated-risk-factors-of-sarcopenia-in-female-patients-with-osteoporotic-fracture
#1
Byung-Ho Yoon, Jun-Ku Lee, Dae-Sung Choi, Soo-Hong Han
Background: We determined the prevalence of sarcopenia according to fracture site and evaluated the associated risk factors in female patients with osteoporotic fractures. Methods: A total of 108 patients aged 50 years or older with an osteoporotic fracture (hip, spine, or wrist) were enrolled in this retrospective observational study. A diagnosis of sarcopenia was confirmed using whole-body densitometry for skeletal muscle mass measurement. Logistic regression analysis was used to analyze the risk factors for sarcopenia...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564306/sarcopenic-obesity-in-elderly-korean-women-a-nationwide-cross-sectional-study
#2
Young Nam Kwon, Sung Sang Yoon, Kyung-Hag Lee
Background: Sarcopenia causes loss of muscle mass in the elderly and is associated with development of metabolic syndrome in those with obesity. This study evaluated the prevalence of sarcopenic obesity (SO) in healthy Korean elderly women. Methods: This study was based on data from the Korea National Health and Nutrition Examination Survey IV and V, 2008-2011. Whole body dual energy X-ray absorptiometry and body mass index measurement were performed for all patients...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564305/the-effect-of-antidepressants-on-mesenchymal-stem-cell-differentiation
#3
Jeffrey S Kruk, Sandra Bermeo, Kristen K Skarratt, Stephen J Fuller, Gustavo Duque
Background: Use of antidepressant medications has been linked to detrimental impacts on bone mineral density and osteoporosis; however, the cellular basis behind these observations remains poorly understood. The effect does not appear to be homogeneous across the whole class of drugs and may be linked to affinity for the serotonin transporter system. In this study, we hypothesized that antidepressants have a class- and dose-dependent effect on mesenchymal stem cell (MSC) differentiation, which may affect bone metabolism...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564304/track-and-field-practice-and-bone-outcomes-among-adolescents-a-pilot-study-abcd-growth-study
#4
Yuri da Silva Ventura Faustino-da-Silva, Ricardo Ribeiro Agostinete, André Oliveira Werneck, Santiago Maillane-Vanegas, Kyle Robinson Lynch, Isabella Neto Exupério, Igor Hideki Ito, Romulo Araújo Fernandes
Background: Osteoporosis is considered a public health problem with high worldwide prevalence. One approach to prevention is through the promotion of physical activity, especially exercise, during adolescence. Methods: This study compared bone variables in different body segments in adolescents according to participation in track and field. The study included 34 adolescents (22 boys), of whom 17 were track and field athletes and 17 were control subjects. Bone mineral density (BMD, g/cm2 ) and bone mineral content (BMC, g) were analyzed using dual energy X-ray absorptiometry (total body stratified by body segments)...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564303/%C3%AE-tocopheryl-succinate-inhibits-osteolytic-bone-metastasis-of-breast-cancer-by-suppressing-migration-of-cancer-cells-and-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-expression-of-osteoblasts
#5
Bongjun Kim, Hong-Hee Kim, Zang Hee Lee
Background: Breast cancer is one of the most common cancers affecting women and has a high incidence of bone metastasis, causing osteolytic lesions. The elevated expression of receptor activator of nuclear factor-κB ligand (RANKL) in cancer activates osteoclasts, leading to bone destruction. We previously reported that α-tocopheryl succinate (αTP-suc) inhibited interleukin-1-induced RANKL expression in osteoblasts. Here, we examined the effect of αTP-suc on osteolytic bone metastasis in breast cancer...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564302/new-skeletal-muscle-mass-index-in-diagnosis-of-sarcopenia
#6
Jeong Jae Moon, Sam-Guk Park, Seung Min Ryu, Chan-Ho Park
Background: We sought to develop a novel index based on the skeletal muscle mass that reflects the change of quality of life (QOL), and is the most appropriate index for the body composition of the elderly in Korea. Whether lower extremity skeletal muscle mass index (LESMI) is an appropriate novel new index to diagnose patients with sarcopenia was also evaluated. A cut-off value for each index was reported to facilitate the diagnosis of patients with sarcopenia in a Korean population...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564301/trans-differentiation-via-epigenetics-a-new-paradigm-in-the-bone-regeneration
#7
REVIEW
Young-Dan Cho, Hyun-Mo Ryoo
In regenerative medicine, growing cells or tissues in the laboratory is necessary when damaged cells can not heal by themselves. Acquisition of the required cells from the patient's own cells or tissues is an ideal option without additive side effects. In this context, cell reprogramming methods, including the use of induced pluripotent stem cells (iPSCs) and trans-differentiation, have been widely studied in regenerative research. Both approaches have advantages and disadvantages, and the possibility of de-differentiation because of the epigenetic memory of iPSCs has strengthened the need for controlling the epigenetic background for successful cell reprogramming...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29564300/review-of-epidemiology-diagnosis-and-treatment-of-osteosarcopenia-in-korea
#8
REVIEW
Jun-Il Yoo, Yong-Chan Ha
Sarcopenia was listed in the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) as M62.84, on October 1, 2016. Sarcopenia is primarily associated with metabolic diseases, such as diabetes, obesity, and cachexia, as well as chronic renal failure, congestive heart failure, and chronic obstructive pulmonary disease. Sarcopenia is also significantly associated with osteoporosis in elderly populations and the combined disease is defined as osteosarcopenia. Several studies have confirmed that sarcopenia and osteoporosis (osteosarcopenia) share common risk factors and biological pathways...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259966/x-linked-hypophosphatemic-rickets-del-2-q37-1-q37-3-deletion-syndrome-and-mosaic-turner-syndrome-mos-45-x-46-x-del-2-q37-1-q37-3-in-a-3-year-old-female
#9
Alaina P Vidmar, Brian Miyazaki, Pedro A Sanchez-Lara, Pisit Pitukcheewanont
There are currently no published cases that report concomitant Turner syndrome (TS), 2q37 deletion syndrome and X-linked hypophosphatemic rickets (XLH). Interestingly, since the clinical phenotypes of TS and 2q37 deletion syndrome overlap, the correct diagnosis may be missed without a standardized approach to genetic testing consisting of both karyotype and microarray. Both chromosome anomalies have been associated with short stature and a variety of skeletal abnormalities however to date no reports have associated these syndromes in association with a phosphate regulating endopeptidase homolog, X-linked ( PHEX ) gene deletion resulting in XLH...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259965/clinical-characteristics-causes-and-survival-in-115-cancer-patients-with-parathyroid-hormone-related-protein-mediated-hypercalcemia
#10
Joon Jin, Jin Ook Chung, Min Young Chung, Dong Hyeok Cho, Dong Jin Chung
Background: The aim of this study is to determine the proportion of cancers presenting with parathyroid hormone (PTH) related protein (PTHrP)-mediated hypercalcemia, examine the clinical and biochemical characteristics, identify predictive factors for survival. And we also compared those characteristics between solid organ and hematologic malignancy groups. Methods: Cancer patients with PTHrP-mediated hypercalcemia who were treated at Chonnam National University Hospital in Korea from January 2005 to January 2015 were retrospectively reviewed...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259964/prevalence-of-osteoporosis-in-korean-patients-with-chronic-obstructive-pulmonary-disease-and-their-health-related-quality-of-life-according-to-the-korea-national-health-and-nutrition-examination-survey-2008-2011
#11
Sang Hee Lee, Hye-Young Kwon
Background: In this study, we evaluated the prevalence of osteoporosis, risk factors associated with osteoporosis, and health-related quality of life (HRQOL) in clinically stable chronic obstructive pulmonary disease (COPD) patients. Methods: A total of 1,081 COPD patients were recruited from the Korea National Health and Nutrition Examination Survey (KNHANES) from July 2008 to May 2011. Bone mineral densities at the lumbar spine, femoral neck, and total proximal femur were measured using dual energy X-ray absorptiometry...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259963/comparison-of-bone-mineral-density-and-appendicular-lean-body-mass-between-osteoporotic-distal-radius-fracture-and-degenerative-rotator-cuff-tear-in-women-patients
#12
Jun-Ku Lee, Byung-Ho Yoon, Kyunghun Jung, Gotak Kim, Soo-Hong Han
Background: Authors assessed lean body mass (fat free tissue), upper and lower, and bone mineral density (BMD) in patients of osteoporotic bone distal radius fracture (DRF) and degenerative rotator cuff tear (RCT) patients of shoulder. We predict inferior muscle mass and osteoporosis are more frequent in DRF group than RCT group. Methods: Between January 2016 and June 2017, overall 38 of DRF and 30 of RCT were eligible for this retrospective comparison study after excluding of patients with compounding factors...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259962/serum-vitamin-d-level-related-to-coffee-consumption-in-korean-young-adults-using-the-5th-korea-national-health-and-nutrition-examination-survey
#13
Hee-Sook Lim, Hae-Hyeog Lee, Dong-Won Byun, Bora Lee, Temuulee Enkhbold, Tae-Hee Kim
Background: Even young adults are highly interested in their osteological health, yet their calcium intake does not match the level of such interest. Increase in bone loss is known to be associated with higher intake of caffeine and coffee consumption among the young Korean is rising steadily. This study was conducted to reveal the relationship between coffee consumption and serum vitamin D level in Korean young adults. Methods: This study analyzed potential difference in lifestyle and concentration of vitamin D in blood in relation to coffee intake frequency of 2,523 subjects on the basis of data from the 5th Korea National Health and Nutrition Examination Survey...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259961/relationship-between-serum-25-hydroxy-vitamin-d-concentration-and-risk-of-metabolic-syndrome-in-patients-with-fatty-liver
#14
Hee-Sook Lim, Tae-Hee Kim, Hae-Hyeog Lee, Soon-Kyung Kim, Bora Lee, Yoon-Hyung Park
Background: The vitamin D deficiency rate in Koreans is still high and dietary intake is insufficient. The purpose of this study was to provide basic data for the management of metabolic syndrome (MetS) by analyzing the effect of vitamin D levels on the MetS in patients with fatty liver. Methods: We analyzed the MetS ratio and serum 25-hydroxy-vitamin D (25[OH]D) concentration in 151 adults diagnosed with fatty liver by using obesity index and blood profiles. We collected data on demographic factors, nutrient intake, and lifestyle habits...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259960/factors-affecting-bone-mineral-density-measurement-after-fracture-in-south-korea
#15
Jin-Woo Kim, Yong-Chan Ha, Young-Kyun Lee
Background: Prior osteoporotic fractures are strongly associated with the subsequent fractures. To prevent this, the diagnosis of osteoporosis following an osteoporotic fracture is important. The measurement of bone mineral density (BMD) is the first step for the diagnosis and management of osteoporosis. Therefore, the purposes of this study are 1) to evaluate the rate of BMD measurement after osteoporotic fracture in Korean population; and 2) determine the associated factors with BMD measurement after fractures among Korean patients...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259959/fexaramine-inhibits-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-induced-osteoclast-formation-via-nuclear-factor-of-activated-t-cells-signaling-pathways
#16
Ting Zheng, Na-Young Kim, Mijung Yim
Background: Osteoclasts are bone resorbing cells and are responsible for bone erosion in diseases as diverse as osteoporosis, periodontitis, and rheumatoid arthritis. Fexaramine has been developed as an agonist for the farnesoid X receptor (FXR). This study investigated the effects of fexaramine on receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced osteoclast formation and signaling pathways. Methods: Osteoclasts were formed by culturing mouse bone marrow-derived macrophages (BMMs) with macrophage colony-stimulating factor (M-CSF) and RANKL...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29259958/bone-density-status-in-bleeding-disorders-where-are-we-and-what-needs-to-be-done
#17
REVIEW
Hassan Mansouritorghabeh, Zahra Rezaieyazdi
Bleeding disorders, including hemophilia, can be seen in every ethnic population in the world. Among various bleeding disorders, reduced bone density has been addressed in hemophilia A. In recent years, there has been an increasing interest in addressing osteopenia and osteoporosis in hemophilia A. There is little or no study about the possible susceptibility of other individuals with bleeding disorders to reduced bone density. Questions have been raised about the role of blood coagulation factors in bone mineralization...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28955696/atraumatic-bilateral-fracture-of-the-femoral-neck-in-young-male-patient-with-suspected-osteomalacia
#18
Byung-Ho Yoon, Min-Soo Kwon
In this report, we describe the case of a healthy 37-year-old male patient without a history of disease, who developed atraumatic bilateral fracture of the femoral neck. Radiological and blood investigations revealed osteopenia and severe vitamin D deficiency (7.42 ng/mL), respectively, but patient had no apparent risk factors for insufficiency fracture. Bilateral osteosynthesis was obtained using cannulated screws and laboratory findings improved after vitamin D supplementation. This case highlights the effect of vitamin D deficiency on demineralization in a young male patient...
August 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28955695/quality-of-life-in-patients-with-osteoporotic-vertebral-compression-fractures
#19
Ho Jin Jung, Ye-Soo Park, Hyoung-Yeon Seo, Jae-Chul Lee, Ki-Chan An, Jin-Hyok Kim, Byung-Joon Shin, Tae Wook Kang, Si Young Park
BACKGROUND: This study aimed to evaluate quality of life (QOL) using the EuroQOL-5 dimensions (EQ-5D) index and to examine factors affecting QOL in patients with an osteoporotic vertebral compression fracture (OVCF). METHODS: This ambispective study used a questionnaire interview. Patients over 50 years old with an OVCF at least 6 months previously were enrolled. Individual results were used to calculate the EQ-5D index. Statistical analysis was performed, and factors related to QOL were examined...
August 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28955694/change-of-bone-mineral-density-measurement-among-patients-with-osteoporotic-fractures-in-korean-population-using-national-claim-database
#20
Chan Ho Park, Young-Kyun Lee, Yong-Chan Ha
BACKGROUND: Prior osteoporotic fractures are strongly associated with subsequent fractures. To prevent this, the diagnosis of osteoporosis following an osteoporotic fracture is important. The measurement of bone mineral density (BMD) is the first step in the diagnosis and management of osteoporosis. Therefore, this study aimed 1) to evaluate the rate of BMD measurement after osteoporotic fracture in the Korean population, and 2) to determine whether the rate of BMD measurement after osteoporotic fracture changed between 2005 and 2010...
August 2017: Journal of Bone Metabolism
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