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Journal of Basic and Clinical Pharmacy

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https://www.readbyqxmd.com/read/27330262/antibacterial-synergy-of-curcumin-with-antibiotics-against-biofilm-producing-clinical-bacterial-isolates
#1
Arunava Kali, Devaraj Bhuvaneshwar, Pravin M V Charles, Kunigal Srinivasaiah Seetha
INTRODUCTION: The role of natural bioactive substances in treating infections has been rediscovered as bacterial resistance become common to most of the antibiotics. Curcumin is a bioactive substance from turmeric. Owing to antimicrobial properties, its prospect as an antibacterial agent is currently under focus. MATERIALS AND METHODS: We have evaluated the in vitro synergy of curcumin with antibiotics against sixty biofilm producing bacterial isolates. Congo red agar method was used to identify the biofilm producing isolates...
June 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27330261/knowledge-of-healthcare-professionals-about-medication-errors-in-hospitals
#2
Mohamed M M Abdel-Latif
CONTEXT: Medication errors are the most common types of medical errors in hospitals and leading cause of morbidity and mortality among patients. AIMS: The aim of the present study was to assess the knowledge of healthcare professionals about medication errors in hospitals. SETTINGS AND DESIGN: A self-administered questionnaire was distributed to randomly selected healthcare professionals in eight hospitals in Madinah, Saudi Arabia. SUBJECTS AND METHODS: An 18-item survey was designed and comprised questions on demographic data, knowledge of medication errors, availability of reporting systems in hospitals, attitudes toward error reporting, causes of medication errors...
June 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27330260/monitoring-of-adverse-drug-reactions-in-psychiatry-outpatient-department-of-a-secondary-care-hospital-of-ras-al-khaimah-uae
#3
Sathvik Belagodu Sridhar, Sura Saad Faris Al-Thamer, Riadh Jabbar
BACKGROUND: Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality, resulting in increased healthcare cost. Association of psychotropic medications with ADRs is common. Pharmacovigilance can play a vital role in alerting the healthcare providers from the possible ADRs and thus protecting the patients receiving psychotropic medications. AIM: To monitor and report the incidence and nature of ADRs in psychiatry outpatient department (OPD)...
June 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27330259/antioxidant-and-hepatoprotective-properties-of-indian-sunderban-mangrove-bruguiera-gymnorrhiza-l-leave
#4
Tapas Kumar Sur, Avijit Hazra, Alok Kumar Hazra, Dipankar Bhattacharyya
BACKGROUND: Bruguiera gymnorrhiza L. (family Rhizophoraceae) is a true mangrove habitat in Indian Sunderban and traditionally uses for liver disorders. OBJECTIVES: The aim was to evaluate antioxidant and hepatoprotective actions of leave extract of B. gymnorrhiza L. MATERIALS AND METHODS: Hydro-methanolic extract of mangrove leaves (BR) was standardized using spectrophotometric and high-performance thin layer chromatography methods. Radical scavenging activities were assessed in different in vitro methods, like 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid (+), superoxides, nitric oxides and hydroxyl radicals...
June 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27330258/prevalence-and-assessment-of-biochemical-parameters-of-attention-deficit-hyperactivity-disorder-children-in-bangladesh
#5
Chowdhury Mohammad Monirul Hasan, Mohammad Monirul Islam, Muhammad Mamunur Rashid Mahib, Mahmud Ahmed Chowdhury Arju
BACKGROUND AND OBJECTIVES: This study aimed to evaluate some new biochemical parameters that help ensuring the early and precise diagnosis of attention-deficit hyperactivity disorder (ADHD) in blood plasma. DESIGN AND SETTINGS: A prospective study conducted with patients scheduled for some new biochemical parameters that help ensuring the early and precise diagnosis of ADHD in blood plasma in a Child Development Center of the Chittagong, Bangladesh. MATERIALS AND METHODS: The study was carried out at two levels...
June 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27330257/therapeutic-monitoring-of-amikacin-and-gentamicin-in-critically-and-noncritically-ill-patients
#6
Tijana Kovačević, Sanja Avram, Dragana Milaković, Nikolina Špirić, Pedja Kovačević
OBJECTIVE: Therapeutic drug monitoring (TDM) enables individualization in the treatment to optimize clinical benefit and minimize drugs' side effects. Critically ill septic patients represent a challenge for antimicrobial treatment because of pathophysiological impact of sepsis on pharmacokinetics of drugs. The aim of this study was to assess the appropriateness of gentamicin and amikacin dosing in critically and noncritically ill patients, as well as to estimate the need for its regular therapeutic monitoring...
June 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27057127/rapid-transformation-of-chronic-lymphocytic-leukemia-to-acute-lymphoblastic-leukemia-a-rare-case-report
#7
Manmeet Kaur, Sarita Nibhoria, Kanwardeep Tiwana, Akanksha Bajaj, Sahil Chhabra
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature-appearing lymphocytes in blood, bone marrow, lymph nodes, and spleen with a median lymphocyte count of 20-30 × 10(9)/L at the time of diagnosis. In half of the patients, the lymphocyte count doubles over a period of 1-year and cyclic rise up to 50 × 10(9)/L can occur in untreated patients while in others the count may remain stable for years. Based on the cytogenetic and molecular studies, it has been demonstrated that multiple clones may occur in CLL and clonal evolution is a frequent occurrence...
March 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27057126/quality-of-life-clinical-effectiveness-and-satisfaction-in-patients-with-beta-thalassemia-major-and-sickle-cell-anemia-receiving-deferasirox-chelation-therapy
#8
Sefika Pinar Senol, Eyup Naci Tiftik, Selma Unal, Aydan Akdeniz, Bahar Tasdelen, Bahar Tunctan
OBJECTIVES: There is a need to remove excess iron with iron chelation therapy (ICT) to avoid the serious clinical sequelae associated with iron overload in patients with beta thalassemia major (BTM) and sickle cell anemia (SCA). Due to the effects of the diseases and their treatments, ICT is still a major reason for unsatisfactory compliance. The aim of this single-center observational study was to evaluate the quality of life, clinical effectiveness, and satisfaction in pediatric and adult patients with BTM and SCA receiving deferasirox (DFX) chelation therapy...
March 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27057125/fabrication-characterization-and-evaluation-of-microsponge-delivery-system-for-facilitated-fungal-therapy
#9
Afrasim Moin, Tamal K Deb, Riyaz Ali M Osmani, Rohit R Bhosale, Umme Hani
OBJECTIVE: The rationale behind present research vocation was to develop and investigate a novel microsponge based gel as a topical carrier for the prolonged release and cutaneous drug deposition of fluconazole (FLZ); destined for facilitated fungal therapy. MATERIALS AND METHODS: Microsponges were prepared using quasi-emulsion solvent diffusion method using Eudragit S-100. In the direction of optimization, the effect of formulation variables (drug-polymer ratio and amount of emulsifier) and diverse factors affecting physical characteristics of microsponge were investigated as well...
March 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27057124/antiurolithiatic-activity-of-abelmoschus-moschatus-seed-extracts-against-zinc-disc-implantation-induced-urolithiasis-in-rats
#10
Anil T Pawar, Niraj S Vyawahare
BACKGROUND: The commonly used techniques for removing renal calculi are associated with the risk of acute renal injury and increase in stone recurrence which indicates an urgent need for alternate therapy. OBJECTIVES: The aim was to evaluate the antiurolithiatic activity of Abelmoschus moschatus seed extracts in rats. MATERIALS AND METHODS: Urolithiasis was induced by surgical implantations of zinc disc in the urinary bladders of rats. Upon postsurgical recovery, different doses of chloroform (CAM) and methanolic (MAM) extracts of A...
March 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27057123/a-simple-practice-guide-for-dose-conversion-between-animals-and-human
#11
REVIEW
Anroop B Nair, Shery Jacob
Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated with animal weight while extrapolating the doses of therapeutic agents among the species. This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling...
March 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26792959/type-i-hypersensitivity-reaction-as-a-complication-of-lepa
#12
Deepa Manjunath Janthli, Ashutosh Chaturvedi, Shruthi Somashekar, B A Lohith
Adverse drug reaction is defined as response to a drug which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological functions. Type I hypersensitivity reaction is known as anaphylactic reaction which is due to immediate immunoglobulin E-mediated reaction. It is characterized by symptoms such as fever nausea, back pain, angiodema, rash, flushing, etc. Lepa generally refers to the application of pastes formed by mixing powder of herbs with water, milk, etc...
December 2015: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26792958/development-and-validation-of-reversed-phase-high-performance-liquid-chromatography-method-for-estimation-of-lercanidipine-hcl-in-pure-form-and-from-nanosuspension-formulation
#13
Ankita D Chonkar, Renuka S Managuli, Josyula Venkata Rao, Nayanabhirama Udupa
AIM: Quantitative estimation of lercanidipine HCl in bulk material as well as from nanosuspension formulations via a developed reverse phase HPLC method. MATERIALS AND METHODS: Optimized chromatographic condition was used to achieve separation on a Kromasil (100-5c18 250 × 4.6 mm) column using Shimadzu HPLC system. The mobile phase consisted of a mixture of acetate buffer (20 mM pH 4.5) and acetonitrile in the ratio of 10:90, v/v. It is pumped through the chromatographic system at a flow rate of 1 ml/min...
December 2015: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26792957/knowledge-regarding-prescription-of-drugs-among-dental-students-a-descriptive-study
#14
Ankita Jain, Devanand Gupta, Deepika Singh, Yogesh Garg, Antima Saxena, Himani Chaudhary, Alpana Singh, Rajendra Kumar Gupta
INTRODUCTION: The act of indicating one or more drugs to be taken by the patient, its dosage, and the interval of the treatment is known as prescribing. It is a dynamic and individualized clinical process. Cultural, social, economic and promotional factors can influence the pattern of prescription. Thus the present study was conducted to evaluate the drug prescription knowledge in third year and final year dental students at Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India...
December 2015: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26792956/phytochemicals-of-aristolochia-tagala-and-curcuma-caesia-exert-anticancer-effect-by-tumor-necrosis-factor-%C3%AE-mediated-decrease-in-nuclear-factor-kappab-binding-activity
#15
Khetbadei Lysinia Hynniewta Hadem, Rajeshwar Nath Sharan, Lakhan Kma
RATIONALE: The active compounds or metabolites of herbal plants exert a definite physiological action on the human body and thus are widely used in human therapy for various diseases including cancer. Previous studies by our group have reported the anticarcinogenic properties of the two herbal plants extracts (HPE) of Aristolochia tagala (AT) Cham. and Curcuma caesia (CC) Roxb. in diethylnitrosamine-induced mouse liver cancer in vivo. The anticarcinogenic properties of these extracts may be due to the active compounds present in them...
December 2015: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26692740/adverse-drug-reactions-in-the-era-of-multi-morbidity-and-polypharmacy
#16
T Javier Birriel, Reina Uchino, Noran Barry, Tracy Butryn, Donna M Sabol, Pamela L Valenza, Stanislaw P Stawicki
No abstract text is available yet for this article.
September 2015: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26692739/hypersensitivity-reaction-associated-with-phenytoin
#17
T H Indu, Roopa Satyanarayan Basutkar
Hypersensitivity reactions with antiepileptic drugs (AEDs) are generally associated with aromatic AEDs. We present a case of hypersensitivity reactions followed by administration of phenytoin with diazepam and ranitidine in a patient with generalized tonic-clonic seizures. Antigen-antibody reactions or decreased levels of epoxide hydrolase are well known with phenytoin. Increased level of serum phenytoin causing toxicities due to competitive inhibition with diazepam on co-administration was also reported in the literature...
September 2015: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26692738/a-rare-case-of-bilateral-lower-extremity-edema-due-to-low-dose-gabapentin-therapy-in-a-young-male-patient
#18
Arunpreet Kahlon, Naveen Gnanabakthan, Amrita Dhillon, Dinesh Subedi
46 year old male with past medical history of schizoaffective disorder and chronic lower back pain, was admitted for management of worsening depression and anxiety. He was started on gabapentin, 300mg twice daily for his back pain and anxiety symptoms. His only other medication was hydrocodone. Over next few days, he started developing worsening bilateral lower extremity edema. He did not have any cardiovascular related symptoms. Physical exam was only significant for 3+ pitting edema with all laboratory values and imaging being unremarkable...
September 2015: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26692737/respiratory-arrest-due-to-nitrofurantoin-treatment-in-the-absence-of-pulmonary-pathology
#19
Hikmet Çoban
In the case we present, an elderly female patient developed respiratory arrest in the absence of pulmonary pathology after using nitrofurantoin (NF). To our current knowledge, this case is the first in the literature. The patient was monitored on mechanical ventilation, and her condition improved only after discontinuing NF treatment.
September 2015: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/26692736/an-evaluation-of-the-prescribing-patterns-for-under-five-patients-at-a-tertiary-paediatric-hospital-in-sierra-leone
#20
Christine Princess Cole, Peter Bai James, Alusine Tommy Kargbo
PURPOSE: There is limited information on pediatric prescribing in Sierra Leone. This study evaluated prescribing patterns for under-five patients at Ola During Children's Hospital (ODCH) and assessed the extent of rational prescribing. METHODS: A descriptive, cross-sectional, retrospective study of 294 prescriptions, selected by systematic random sampling was conducted at the outpatient department of ODCH. The World Health Organisation prescribing indicators were analyzed using the SPSS package 16...
September 2015: Journal of Basic and Clinical Pharmacy
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