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Journal of Basic and Clinical Pharmacy

Ansha Subramanian, Mangaiarkkarasi Adhimoolam, Senthil Gopalakrishnan, Meher Ali Rajamohammed
Angioedema is a rare adverse reaction of carbamazepine, which causes localized tissue edema in submucosal and subcutaneous tissue mediated by histamine, serotonin, and kinins (bradykinin). We report a case of 34-year-old female who developed angioedema, 24 h after administration of carbamazepine for treating bipolar disorder. Patient's symptoms responded rapidly with antihistamine therapy and with the withdrawal of carbamazepine, the offending drug. Carbamazepine-induced angioedema is a life-threatening reaction which requires immediate treatment and monitoring in order to avoid morbidity and mortality...
September 2016: Journal of Basic and Clinical Pharmacy
Sunday O Nduka, Maureen U Anetoh, Kosisochi C Amorha, Okechukwu O Henry, Mathew J Okonta
RATIONALE: The pharmacist charged with the responsibility of drug administration and counseling should have the basic knowledge and skills necessary to demonstrate the use of metered dose inhalers (MDIs) to asthma patients for the maximization of treatment outcomes. OBJECTIVE: This study was designed to evaluate the community pharmacists' knowledge of the appropriate use of MDIs in Anambra State, Nigeria. METHODS: The study was carried out in two major cities in Anambra State, Nigeria, using 41 registered community pharmacists...
September 2016: Journal of Basic and Clinical Pharmacy
Kartik Nitinbhai Shah, Harsh Manishbhai Joshi, Rohan Piyushkumar Christian, Kamlesh Prahaladbhai Patel, Supriya Dipak Malhotra
AIMS: The aim of this study is to evaluate potentially inappropriate medications (PIMs) in the elderly at cardiology outpatient department (OPD) of a tertiary care teaching hospital using Beers criteria and to find the direct cost burden of PIMs. MATERIALS AND METHODS: The present study was an observational cross-sectional study. Prescriptions of the patients' aged ≥65 years were collected from the cardiology OPD and were analyzed. PIMs were identified with the help of Beers 2012 criteria...
September 2016: Journal of Basic and Clinical Pharmacy
Nagashekhara Molugulu, Kumar Shiva Gubbiyappa, C R Vasudeva Murthy, Lim Lumae, Anil Tumkur Mruthyunjaya
INTRODUCTION: Reports on medication adherence and its associated factors in patients with epilepsy in South East Asian countries are lacking. The primary purpose of this study was to assess the degree of medication adherence and its relationship with patient's satisfaction, psychosocial factors, quality of life and mental health in a sample of Malaysian epilepsy patients. METHODOLOGY: It is a cross-sectional study and was carried out in the outpatient Neurology Department of Hospital Kuala Lumpur, Malaysia (n=272)...
September 2016: Journal of Basic and Clinical Pharmacy
Nikita Shekhar Sawantdesai, Pravin Popatrao Kale, Jay Savai
CONTEXT: Anxiety disorders are chronic, common, and often comorbid. There is an unmet need in its treatment. Aripiprazole and hydroxyzine are well-known therapeutic options used as monotherapy in clinics. They have different mechanisms and site of actions. AIM: The objective of the present study was to evaluate the anxiolytic effect of aripiprazole and hydroxyzine in combination. MATERIALS AND METHODS: Swiss albino mice (male) received treatment of 5% of Tween 80 in 0...
September 2016: Journal of Basic and Clinical Pharmacy
Arunava Kali, Devaraj Bhuvaneshwar, Pravin M V Charles, Kunigal Srinivasaiah Seetha
INTRODUCTION: The role of natural bioactive substances in treating infections has been rediscovered as bacterial resistance become common to most of the antibiotics. Curcumin is a bioactive substance from turmeric. Owing to antimicrobial properties, its prospect as an antibacterial agent is currently under focus. MATERIALS AND METHODS: We have evaluated the in vitro synergy of curcumin with antibiotics against sixty biofilm producing bacterial isolates. Congo red agar method was used to identify the biofilm producing isolates...
June 2016: Journal of Basic and Clinical Pharmacy
Mohamed M M Abdel-Latif
CONTEXT: Medication errors are the most common types of medical errors in hospitals and leading cause of morbidity and mortality among patients. AIMS: The aim of the present study was to assess the knowledge of healthcare professionals about medication errors in hospitals. SETTINGS AND DESIGN: A self-administered questionnaire was distributed to randomly selected healthcare professionals in eight hospitals in Madinah, Saudi Arabia. SUBJECTS AND METHODS: An 18-item survey was designed and comprised questions on demographic data, knowledge of medication errors, availability of reporting systems in hospitals, attitudes toward error reporting, causes of medication errors...
June 2016: Journal of Basic and Clinical Pharmacy
Sathvik Belagodu Sridhar, Sura Saad Faris Al-Thamer, Riadh Jabbar
BACKGROUND: Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality, resulting in increased healthcare cost. Association of psychotropic medications with ADRs is common. Pharmacovigilance can play a vital role in alerting the healthcare providers from the possible ADRs and thus protecting the patients receiving psychotropic medications. AIM: To monitor and report the incidence and nature of ADRs in psychiatry outpatient department (OPD)...
June 2016: Journal of Basic and Clinical Pharmacy
Tapas Kumar Sur, Avijit Hazra, Alok Kumar Hazra, Dipankar Bhattacharyya
BACKGROUND: Bruguiera gymnorrhiza L. (family Rhizophoraceae) is a true mangrove habitat in Indian Sunderban and traditionally uses for liver disorders. OBJECTIVES: The aim was to evaluate antioxidant and hepatoprotective actions of leave extract of B. gymnorrhiza L. MATERIALS AND METHODS: Hydro-methanolic extract of mangrove leaves (BR) was standardized using spectrophotometric and high-performance thin layer chromatography methods. Radical scavenging activities were assessed in different in vitro methods, like 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid (+), superoxides, nitric oxides and hydroxyl radicals...
June 2016: Journal of Basic and Clinical Pharmacy
Chowdhury Mohammad Monirul Hasan, Mohammad Monirul Islam, Muhammad Mamunur Rashid Mahib, Mahmud Ahmed Chowdhury Arju
BACKGROUND AND OBJECTIVES: This study aimed to evaluate some new biochemical parameters that help ensuring the early and precise diagnosis of attention-deficit hyperactivity disorder (ADHD) in blood plasma. DESIGN AND SETTINGS: A prospective study conducted with patients scheduled for some new biochemical parameters that help ensuring the early and precise diagnosis of ADHD in blood plasma in a Child Development Center of the Chittagong, Bangladesh. MATERIALS AND METHODS: The study was carried out at two levels...
June 2016: Journal of Basic and Clinical Pharmacy
Tijana Kovačević, Sanja Avram, Dragana Milaković, Nikolina Špirić, Pedja Kovačević
OBJECTIVE: Therapeutic drug monitoring (TDM) enables individualization in the treatment to optimize clinical benefit and minimize drugs' side effects. Critically ill septic patients represent a challenge for antimicrobial treatment because of pathophysiological impact of sepsis on pharmacokinetics of drugs. The aim of this study was to assess the appropriateness of gentamicin and amikacin dosing in critically and noncritically ill patients, as well as to estimate the need for its regular therapeutic monitoring...
June 2016: Journal of Basic and Clinical Pharmacy
Manmeet Kaur, Sarita Nibhoria, Kanwardeep Tiwana, Akanksha Bajaj, Sahil Chhabra
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature-appearing lymphocytes in blood, bone marrow, lymph nodes, and spleen with a median lymphocyte count of 20-30 × 10(9)/L at the time of diagnosis. In half of the patients, the lymphocyte count doubles over a period of 1-year and cyclic rise up to 50 × 10(9)/L can occur in untreated patients while in others the count may remain stable for years. Based on the cytogenetic and molecular studies, it has been demonstrated that multiple clones may occur in CLL and clonal evolution is a frequent occurrence...
March 2016: Journal of Basic and Clinical Pharmacy
Sefika Pinar Senol, Eyup Naci Tiftik, Selma Unal, Aydan Akdeniz, Bahar Tasdelen, Bahar Tunctan
OBJECTIVES: There is a need to remove excess iron with iron chelation therapy (ICT) to avoid the serious clinical sequelae associated with iron overload in patients with beta thalassemia major (BTM) and sickle cell anemia (SCA). Due to the effects of the diseases and their treatments, ICT is still a major reason for unsatisfactory compliance. The aim of this single-center observational study was to evaluate the quality of life, clinical effectiveness, and satisfaction in pediatric and adult patients with BTM and SCA receiving deferasirox (DFX) chelation therapy...
March 2016: Journal of Basic and Clinical Pharmacy
Afrasim Moin, Tamal K Deb, Riyaz Ali M Osmani, Rohit R Bhosale, Umme Hani
OBJECTIVE: The rationale behind present research vocation was to develop and investigate a novel microsponge based gel as a topical carrier for the prolonged release and cutaneous drug deposition of fluconazole (FLZ); destined for facilitated fungal therapy. MATERIALS AND METHODS: Microsponges were prepared using quasi-emulsion solvent diffusion method using Eudragit S-100. In the direction of optimization, the effect of formulation variables (drug-polymer ratio and amount of emulsifier) and diverse factors affecting physical characteristics of microsponge were investigated as well...
March 2016: Journal of Basic and Clinical Pharmacy
Anil T Pawar, Niraj S Vyawahare
BACKGROUND: The commonly used techniques for removing renal calculi are associated with the risk of acute renal injury and increase in stone recurrence which indicates an urgent need for alternate therapy. OBJECTIVES: The aim was to evaluate the antiurolithiatic activity of Abelmoschus moschatus seed extracts in rats. MATERIALS AND METHODS: Urolithiasis was induced by surgical implantations of zinc disc in the urinary bladders of rats. Upon postsurgical recovery, different doses of chloroform (CAM) and methanolic (MAM) extracts of A...
March 2016: Journal of Basic and Clinical Pharmacy
Anroop B Nair, Shery Jacob
Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated with animal weight while extrapolating the doses of therapeutic agents among the species. This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling...
March 2016: Journal of Basic and Clinical Pharmacy
Deepa Manjunath Janthli, Ashutosh Chaturvedi, Shruthi Somashekar, B A Lohith
Adverse drug reaction is defined as response to a drug which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological functions. Type I hypersensitivity reaction is known as anaphylactic reaction which is due to immediate immunoglobulin E-mediated reaction. It is characterized by symptoms such as fever nausea, back pain, angiodema, rash, flushing, etc. Lepa generally refers to the application of pastes formed by mixing powder of herbs with water, milk, etc...
December 2015: Journal of Basic and Clinical Pharmacy
Ankita D Chonkar, Renuka S Managuli, Josyula Venkata Rao, Nayanabhirama Udupa
AIM: Quantitative estimation of lercanidipine HCl in bulk material as well as from nanosuspension formulations via a developed reverse phase HPLC method. MATERIALS AND METHODS: Optimized chromatographic condition was used to achieve separation on a Kromasil (100-5c18 250 × 4.6 mm) column using Shimadzu HPLC system. The mobile phase consisted of a mixture of acetate buffer (20 mM pH 4.5) and acetonitrile in the ratio of 10:90, v/v. It is pumped through the chromatographic system at a flow rate of 1 ml/min...
December 2015: Journal of Basic and Clinical Pharmacy
Ankita Jain, Devanand Gupta, Deepika Singh, Yogesh Garg, Antima Saxena, Himani Chaudhary, Alpana Singh, Rajendra Kumar Gupta
INTRODUCTION: The act of indicating one or more drugs to be taken by the patient, its dosage, and the interval of the treatment is known as prescribing. It is a dynamic and individualized clinical process. Cultural, social, economic and promotional factors can influence the pattern of prescription. Thus the present study was conducted to evaluate the drug prescription knowledge in third year and final year dental students at Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India...
December 2015: Journal of Basic and Clinical Pharmacy
Khetbadei Lysinia Hynniewta Hadem, Rajeshwar Nath Sharan, Lakhan Kma
RATIONALE: The active compounds or metabolites of herbal plants exert a definite physiological action on the human body and thus are widely used in human therapy for various diseases including cancer. Previous studies by our group have reported the anticarcinogenic properties of the two herbal plants extracts (HPE) of Aristolochia tagala (AT) Cham. and Curcuma caesia (CC) Roxb. in diethylnitrosamine-induced mouse liver cancer in vivo. The anticarcinogenic properties of these extracts may be due to the active compounds present in them...
December 2015: Journal of Basic and Clinical Pharmacy
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