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International Journal of Molecular and Cellular Medicine

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https://www.readbyqxmd.com/read/28890889/a-novel-missense-mutation-in-the-aldh13-gene-causes-anophthalmia-in-two-unrelated-iranian-consanguineous-families
#1
Mohammadreza Dehghani, Masoud Dehghan Tezerjani, Zahra Metanat, Mohammad Yahya Vahidi Mehrjardi
Anophthalmia or microphthalmia (A/M) is a rare group of congenital/developmental ocular malformations, characterized by absent or small eye within the orbit affecting one or both eyes. It has complex etiology with chromosomal, monogenic with high heterogeneity, and environmental causes. We performed genome SNP-array analysis followed by autozygosity mapping and sequencing in the members of two families in which three individuals are suffering from severe bilateral anophthalmia. The genetic analysis revealed a novel missense c...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28890888/association-between-ace-rs4646994-fabp2-rs1799883-mthfr-rs1801133-fto-rs9939609-genes-polymorphism-and-type-2-diabetes-with-dyslipidemia
#2
Syed Tasleem Raza, Shania Abbas, Zeba Siddiqi, Farzana Mahdi
Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) and FTO (rs9939609) genes polymorphism in T2DM with dyslipidemia. Totally, 559 subjects including 221 T2DM cases with dyslipidemia, 158 T2DM without dyslipidemia and 180 controls were enrolled...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28890887/isolation-and-characterization-of-actinobacteria-from-algerian-sahara-soils-with-antimicrobial-activities
#3
Harir Mohamed, Bellahcene Miloud, Fortas Zohra, José María García-Arenzana, Antonio Veloso, Susana Rodríguez-Couto
Extreme ecosystems can be a source of untapped microorganisms to produce novel bioactive compounds of industrial interest. Consequently, in this work, 32 actinomycetes were isolated from 6 soil samples collected from Algerian Sahara in searching for untapped producers of novel antimicrobial compounds. All the isolates were further subjected to antimicrobial screening against pathogenic bacteria, yeast and fungi. The obtained results indicated that three of the isolates (named C, MS1 and 10) showed antimicrobial activities against most of the tested pathogenic microorganisms...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28890886/development-of-a-novel-anti-adhesive-vaccine-against-pseudomonasaeruginosa-targeting-the-c-terminal-disulfide-loop-of-the-pilin-protein
#4
Sobhan Faezi, Ahmad Reza Bahrmand, Mehdi Mahdavi, Seyed Davar Siadat, Iraj Nikokar, Soroush Sardari
Type IV pili (T4P) are major virulence factors of Pseudomonas aeruginosa (P. aeruginosa) that are associated with primary adhesion, biofilm formation and twitching motility. This study focuses on the introduction of a novel biologically active subunit vaccine derived from the disulfide loop (DSL) of P. aeruginosa pilin. We investigated the expression of the novel PilA in-frame with pET26b vector, which contains three domains, that each domain contains three tandem repeats. The flexible (GGGGS) and (GGGGS)3 linkers were linked between the three tandem repeats and each pilA domain, respectively...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28890885/evaluation-of-microrna-99a-and-microrna-205-expression-levels-in-bladder-cancer
#5
Sajjad Mohammad Ganji, Massoud Saidijam, Razieh Amini, Seyed Habibollah Mousavi-Bahar, Nooshin Shabab, Saman Seyedabadi, Ali Mahdavinezhad
Bladder cancer is the second most common cancer in the genitourinary tract, showing often recurrence and progress into invasive states. Epigenetic changes, such as microRNA alteration are involved in bladder cancer tumorigenesis through a variety of signaling pathways. The epigenetic state depends on geographic and lifestyle conditions. The aim of this study was to investigate the expression level of microRNA-99a and microRNA-205 in bladder cancer in Iranian populations and to determine the relationship between their expressions with clinicophatological features...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28890884/circulating-mir-92a-mir-143-and-mir-342-in-plasma-are-novel-potential-biomarkers-for-acute-myeloid-leukemia
#6
Amr Rafat Elhamamsy, Muhammad Suleiman El Sharkawy, Ahmed Farouk Zanaty, Mohammed Ahmed Mahrous, Ahmed Ezzat Mohamed, Eslam Ahmed Abushaaban
MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional gene expression regulators. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. Recent studies have opened the way for the use of circulating miRNAs as non-invasive diagnosis and prognosis of Acute myeloid leukemia (AML). The aim of this study was to identify plasma miR-92a, miR-143 and miR-342 expression signatures in AML patients to introduce new markers for establishing AML diagnosis and prognosis...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28890883/the-role-of-probiotics-in-cancer-treatment-emphasis-on-their-in-vivo-and-in-vitro-anti-metastatic-effects
#7
REVIEW
Elahe Motevaseli, Ali Dianatpour, Soudeh Ghafouri-Fard
Probiotics are defined as live bacteria and yeasts that exert beneficial effects for health. Among their various effects, anti-cancer properties have been highlighted in recent years. Such effects include suppression of the growth of microbiota implicated in the production of mutagens and carcinogens, alteration in carcinogen metabolism and protection of DNA from oxidative damage as well as regulation of immune system. We performed a computerized search of the MEDLINE/PUBMED databases with key words: cancer, probiotics, lactobacilli, metastasis and invasion...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28868271/prenatal-diagnosis-of-mosaic-tetrasomy-18p-in-a-case-without-sonographic-abnormalities
#8
Javad Karimzad Hagh, Thomas Liehr, Hamid Ghaedi, Mir Majid Mossalaeie, Shohreh Alimohammadi, Faegheh Inanloo Hajiloo, Zahra Moeini, Sadaf Sarabi, Davood Zare-Abdollahi
Small supernumerary marker chromosomes (sSMC) are still a major problem in clinical cytogenetics as they cannot be identified or characterized unambiguously by conventional cytogenetics alone. On the other hand, and perhaps more importantly in prenatal settings, there is a challenging situation for counseling how to predict the risk for an abnormal phenotype, especially in cases with a de novo sSMC. Here we report on the prenatal diagnosis of a mosaic tetrasomy 18p due to presence of an sSMC in a fetus without abnormal sonographic signs...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28868270/torque-teno-virus-ttv-among-%C3%AE-thalassemia-and-haemodialysis-patients-in-mazandaran-province-north-of-iran
#9
Hossein Jalali, Mohammad Reza Mahdavi, Najmeh Zaeromali
Torque Teno virus (TTV) is a transfusion transmitted virus that seems to be involved in several complications such as acute respiratory diseases, liver diseases, AIDS, cancer, and autoimmune reactions. In the present study the frequency of TTV was investigated among β- thalassemia (BT) and haemodialysis (HD) patients (high risk patients for TTV) in Mazandaran province, Iran. DNA was extracted from the serum of 82 BT and 100 HD patients, and nested PCR method was applied to detect TTV DNA. The aspartate transaminase(AST) and alanine transaminase (ALT) enzyme levels in BT patients were measured using photometric assay...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28868269/determination-of-bacteriocin-genes-and-antibacterial-activity-of-lactobacillus-strains-isolated-from-fecal-of-healthy-individuals
#10
Meysam Hasannejad Bibalan, Morteza Eshaghi, Mahdi Rohani, Mohammad Reza Pourshafie, Malihe Talebi
Lactobacillus species play a major role in gastrointestinal (GI) tract function, intestinal microbiota balance, and the immune system activity by exerting a strong activity against many intestinal pathogens. The aim of this study was to isolate Lactobacillus species from fecal samples, investigate their antimicrobial properties, and characterize their bacteriocin encoding genes. 48 fecal samples were grown in MRS broth and then MRS agar. The colonies grown in MRS agar were selected and identified by PCR. 72 Lactobacillus species were obtained from 434 lactic acid bacteria (LAB) strains...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28868268/effect-of-concentrated-apple-extract-on-experimental-colitis-induced-by-acetic-acid
#11
Maurício Mercaldi Pastrelo, Carla Caroline Dias Ribeiro, Joselmo Willamys Duarte, Andréa Pitelli Bioago Gollücke, Ricardo Artigiani-Neto, Daniel Araki Ribeiro, Sender Jankiel Miszputen, Celina Tizuko Fujiyama Oshima, Ana Paula Ribeiro Paiotti
Reactive oxygen and nitrogen species (ROS/RNS) play a crucial role in inflammatory bowel disease (IBD) exacerbating the chronic inflammatory process. Endogenous and diet antioxidants can neutralize these compounds. The apple is widely consumed, with several antioxidant activity compounds. The present study evaluated the effects of concentrated apple extract (CAE) in acetic acid induced colitis. 29 Wistar male rats were randomized into 5 groups. G1-Sham/saline solution, G2-CAE/control, G3-acetic acid/control, G4-curative- CAE treatment and G5-preventive-CAE treatment...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28868267/analysis-of-two-cdkn2b-as-polymorphisms-in-relation-to-coronary-artery-disease-patients-in-north-of-iran
#12
Maryam Mafi Golchin, Sayyed Mohammad Hossein Ghaderian, Haleh Akhavan-Niaki, Rozita Jalalian, Laleh Heidari, Seyed Alireza Salami
Coronary artery disease (CAD) including myocardial infarction (MI) as its complication, is one of the most common heart diseases worldwide and also in Iran, with extremely elevated mortality. CAD is a multifactorial disorder. Twin and family studies at different loci have demonstrated that genetic factors have an important role in the progression of CAD. Many studies have reported a significant association of CDKN2B-AS, also known as ANRIL which is located within the p15, p16, p14 gene cluster at 9p21 locus, with cardiovascular diseases as well as many other diseases like diabetes and cancers...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28868266/evaluation-of-placental-mir-155-5p-and-long-non-coding-rna-sone-expression-in-patients-with-severe-pre-eclampsia
#13
Faezeh Azizi, Soraya Saleh Gargari, Sedigheh Asadi Shahmirzadi, Fatemeh Dodange, Vahid Amiri, Reza Mirfakhraie, Mir Davood Omrani
It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental non-coding RNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28868265/medip-real-time-qpcr-has-the-potential-for-noninvasive-prenatal-screening-of-fetal-trisomy-21
#14
Mohammad Kazemi, Mansoor Salehi, Majid Kheirollahi
This study aimed to verify the reliability of the 7 tissue differentially methylated regions used in the methylated DNA immunoprecipitation (MeDIP) real- time quantitative polymerase chain reaction (real-time qPCR) based approach of fetal DNA in maternal blood to diagnosis of fetal trisomy 21. Forty pregnant women with high risk pregnancy who were referred after first or second trimester screening tests, were selected randomly. For each sample whole DNA extraction (mother and fetus), fragmentation of DNA, immunoprecipitation of methylated DNA and real- time qPCR using 7 primer pairs was performed...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28868264/the-role-of-long-non-coding-rnas-in-the-repair-of-dna-double-strand-breaks
#15
REVIEW
Ali Dianatpour, Soudeh Ghafouri-Fard
DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effects of these lesions in cell. The role of protein coding genes in regulation of these pathways has been assessed previously...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28357203/a-novel-splicesite-mutation-in-the-edar-gene-causes-severe-autosomal-recessive-hypohydrotic-anhidrotic-ectodermal-dysplasia-in-an-iranian-family
#16
Shahram Torkamandi, Milad Gholami, Javad Mohammadi-Asl, Somaye Rezaie, Mohammad Ali Zaimy, Mir Davood Omrani
Hypohidrotic ectodermal dysplasia (HED) is a rare congenital disorder arising from deficient development of ectoderm-derived structures including skin, nails, glands and teeth. The phenotype of HED is associated with mutation in EDA, EDAR, EDARADD and NEMO genes, all of them disruptingNF-κB signaling cascade necessary for initiation, formation and differentiation in the embryo and adult. Here we describe a novel acceptor splice site mutation c.730-2 A>G(IVS 8-2 A>G) in EDAR gene in homozygous form in all affected members of a family,and in heterozygous form in carriers...
2016: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28357202/a-novel-nonsense-mutation-in-pank2-gene-in-two-patients-with-pantothenate-kinase-associated-neurodegeneration
#17
Soudeh Ghafouri-Fard, Vahid Reza Yassaee, Alireza Rezayi, Feyzollah Hashemi-Gorji, Nasrin Alipour, Mohammad Miryounesi
Pantothenate kinase- associated neurodegeneration (PKAN) syndrome is a rare autosomal recessive disorder characterized by progressive extrapyramidal dysfunction and iron accumulation in the brain and axonal spheroids in the central nervous system. It has been shown that the disorder is caused by mutations in PANK2 gene which codes for a mitochondrial enzyme participating in coenzyme A biosynthesis. Here we report two cases of classic PKAN syndrome with early onset of neurodegenerative disorder. Mutational analysis has revealed that both are homozygous for a novel nonsense mutation in PANK2 gene (c...
2016: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28357201/should-we-perform-semen-analysis-dna-fragmentation-and-hypo-osmotic-swelling-tests-together
#18
Samaneh Hasanzadeh Keshteli, Mir Mehrdad Farsi, Soraya Khafri
Semen analysis, sperm DNA fragmentation (SDF) and hypo-osmotic swelling test (HOST) are usually performed for the evaluation of sperm fertilizing ability. There are some debates over the necessity of SDF and HOST incorporation in male infertility work-up.Semen of 77 men was evaluated by SDF and HOST through three semen analyses. Sperm parameters were arranged into different categories: <5%, 5-15%, >15% for normal morphology; <50%, 50-70%, >70 % for motility; and <10, 10-20, 21-34, 35-50, >50 million/ml for concentration...
2016: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28357200/analysis-of-copy-number-variations-in-patients-with-autism-using-cytogenetic-and-mlpa-techniques-report-of-16p13-1p13-3-and-10q26-3-duplications
#19
Saghar Ghasemi Firouzabadi, Roshanak Vameghi, Roxana Kariminejad, Hossein Darvish, Susan Banihashemi, Mahboubeh Firouzkouhi Moghaddam, Peyman Jamali, Hassan Farbod Mofidi Tehrani, Hossein Dehghani, Mohammad Reza Raeisoon, Mehrnaz Narooie-Nejad, Javad Jamshidi, Abbas Tafakhori, Saeid Sadabadi, Farkhondeh Behjati
Autism is a common neuropsychiatric disorder affecting 1 in 68 children. Copy number variations (CNVs) are known to be major contributors of autism spectrum disorder (ASD). There are different whole genome or targeted techniques to identify CNVs in the patients including karyotyping, multiplex ligation-dependent probe amplification (MLPA) and array CGH. In this study, we used karyotyping and MLPA to detect CNVs in 50 Iranian patients with autism. GTG banding and 4 different MLPA kits (2 subtelomeric and 2 autism kits) were utilized...
2016: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28357199/a-comparison-between-the-effect-of-cuminum-cyminum-and-vitamin-e-on-the-level-of-leptin-paraoxonase-1-hba1c-and-oxidized-ldl-in-diabetic-patients
#20
Ghatreh Samani Keihan, Mohammad Hossein Gharib, Ali Momeni, Zohreh Hemati, Roya Sedighin
Diabetes is one of the most common metabolic diseases in the world. Vitamin E reduces protein glycation and improves insulin sensitivity, while cumin is effective in remission of diabetes. Therefore this study was designed to evaluate the effects of vitamin E and cumin essential oil, on the blood level of leptin,glycosylated hemoglobin (HbA1C) and also on lipid profile in diabetic patients.In this double blind clinical trial, 95 diabetic patients were selected and randomly dividedinto three groups.The first group received cumin essential oil in capsule form...
2016: International Journal of Molecular and Cellular Medicine
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