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International Journal of Molecular and Cellular Medicine

Javad Jamshidi, Hamed Naderi, Shaghayegh Taghavi, Babak Emamalizadeh, Hossein Darvish
No abstract text is available yet for this article.
2016: International Journal of Molecular and Cellular Medicine
Atieh Zorrieh Zahra, Sepideh Kadkhoda, Farkhondeh Behjati, Fatemeh Aghakhani Moghaddam, Azadeh Badiei, Fereidoon Sirati, Hossein Afshin Alavi, Morteza Atri, Ramesh Omranipour, Elahe Keyhani
Male breast cancer is a rare disease with an increasing trend. Due to limited information especially about the genetic basis of the disease in Iran and the lower age of its onset, the disease requires more attention. The aim of this study was to screen the male patients with breast cancer for BRCA mutations as well as tissue markers of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER-2) and cytokeratin 5/6 (CK5/6). Ten Iranian males with breast cancer were selected regardless of their histologic subtypes, age and family history from patients referred to Mehrad, Day and Parsian hospitals in Tehran, Iran, during a two-year period...
2016: International Journal of Molecular and Cellular Medicine
Tahoora Shomali, Mohammad Kamalpour, Mehdi Fazeli, Alireza Rafati
The present study describes the changes in expression of hydroxy- carboxylic acid receptor 2 (HCA2 receptor) in femoral epiphysis and metaphysis of rats with glucocorticoid-induced osteoporosis (GIO). 16 growing male Sprauge dawley rats were randomly divided into two equal groups consisting of normal control and rats that were rendered osteoporotic by receiving 0.1 mg/kg/day dexamethasone subcutaneously. After 4 weeks, all rats were sacrificed and immediately right and left femoral bones were removed for RT-qPCR and histological examination, respectively...
2016: International Journal of Molecular and Cellular Medicine
Mohsen Hosinian, Durdi Qujeq, Alijan Ahmadi Ahangar
Changes in extra and intracellular neurotransmitter amino acids concentration in the early stage of acute cerebral ischemia have been reported. In this the study, serum level of gamma aminobutyric acid (GABA) and L-Arginine in acute ischemic stroke patients was assessed. 60 patients with acute ischemic stroke and sixthy healthy volunteers as a control group were assessed. Serum GABA was measured with modified enzymatic method and serum L- Arginine was measured by modified Sakaguchi method. Serum GABA level in stroke cases was lower than that of the control group...
2016: International Journal of Molecular and Cellular Medicine
Farhad Zaker, Naser Amirizadeh, Nahid Nasiri, Seyed Mohsen Razavi, Ladan Teimoori-Toolabi, Marjan Yaghmaie, Roya Mehrasa
Myelodysplastic syndromes (MDSs) are a clonal bone marrow (BM) disease characterized by ineffective hematopoiesis, dysplastic maturation and progression to acute myeloid leukemia (AML). Methylation silencing of HRK has been found in several human malignancies. In this study, we explored the association of HRK methylation status with its expression, clinical parameters and MDS subtypes in MDS patients. To study the methylation status of HRK gene, we applied Methylation Sensitive-High Resolution Melting Curve Analysis (MS-HRM) in MDS patients, as well as healthy controls and EpiTect®PCR Control DNA...
2016: International Journal of Molecular and Cellular Medicine
Ebrahim Eftekhar, Hajar Jaberie, Fakhraddin Naghibalhossaini
Understanding the mechanism of tumor resistance is critical for cancer therapy. In this study, we investigated the effect of carcinoembryonic antigen (CEA) overexpression on UV-and 5-fluorouracil (5-FU)-induced apoptosis and autophagy in colorectal cancer cells. We used histone deacetylase (HDAC) inhibitor, NaB and DNA demethylating agent, 5-azacytidine (5-AZA) to induce CEA expression in HT29/219 and SW742 colorectal cancer cell lines. MTT assay was used to measure IC50 value of the cells exposed to graded concentrations of 5- FU with either 0...
2016: International Journal of Molecular and Cellular Medicine
Behnam Alipoor, Hamid Ghaedi, Mir Davood Omrani, Milad Bastami, Reza Meshkani, Taghi Golmohammadi
It has been suggested that single nucleotide polymorphisms (SNPs) in genes involved in Toll-like receptors (TLRs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. However, the extent to which these variations affect TLR signaling is not well understood. In this study, we adopted a bioinformatics approach to predict the consequences of SNPs in TLRs network. The consequences of non-synonymous coding SNPs (nsSNPs) were predicted by SIFT, PolyPhen, PANTHER, SNPs&GO, I-Mutant, ConSurf and NetSurf tools...
2016: International Journal of Molecular and Cellular Medicine
Debarshi Sanyal, Vidya Bhairi, Jayarama S Kadandale
We present 2 cases of likely rare event. In case 1, 3(rd) degree consanguineous marriage revealed inv(6) with same break points in parents who were found to be phenotypically normal. The same inv(6) being inherited in progeny but presented with low AMH (anti Mullerian hormone) and high level of FSH (follicular stimulating hormone) leading to polycystic ovarian syndrome/premature ovarian failure. In case 2, a couple was presented with 2(nd) degree consanguineous marriage and referred for 2 recurrent/ missed abortions...
2016: International Journal of Molecular and Cellular Medicine
Alejandro García-Muñoz, Ronell Bologna-Molina, Mario A Rodríguez, Rodrigo Liceága-Reyes, Jose Eduardo Farfán-Morales, Saray Aranda-Romo, Nelly Molina-Frechero, Rogelio González-González
Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques...
2016: International Journal of Molecular and Cellular Medicine
Sobhan Faezi, Ahmad Reza Bahrmand, Mehdi Mahdavi, Seyed Davar Siadat, Iraj Nikokar, Soroush Sardari, Ian Alan Holder
Pseudomonas aeruginosa as an opportunistic pathogen is a significant cause of acute and chronic infections in patients with compromised defenses. This bacterium is motile via a single polar flagellum made of polymerized flagellin subunits differentiated into two major serotypes: A and B. flagellin plays an important role as a virulence factor in the adhesion, colonization and invasion of P. aeruginosa into host epithelial cells. To develop a functional vaccine that can be used in practical application to prevent and treat infection, type B-flagellin was produced as recombinant protein...
2016: International Journal of Molecular and Cellular Medicine
Pouria Mohammadi, Massoud Saidijam, Arastoo Kaki, Katayoon Etemadi, Nooshin Shabab, Reza Yadegarazari
Colorectal cancer remains one of the major cancer- related deaths despite progress in the treatment during past decades. Detection of disease at earlier stages reduces its mortality. The aim of current study was to investigate expression of Cytokeratin 19 (CK19), Cytokeratin 20 (CK20) and Guanylyl Cyclase C (GCC) mRNA in peripheral blood of non- metastatic colorectal cancer patients which may result into introducing of an early detection test. 25 patients with colorectal cancer and 25 healthy controls were recruited...
2016: International Journal of Molecular and Cellular Medicine
Seyed Mohsen Aghajanpour-Mir, Ebrahim Zabihi, Haleh Akhavan-Niaki, Elahe Keyhani, Iman Bagherizadeh, Sajjad Biglari, Farkhondeh Behjati
Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification. In this study, we investigated the BPA-induced chromosomal damages in MCF-7 cell line, ER-positive and negative amniocyte cells...
2016: International Journal of Molecular and Cellular Medicine
Seyed Reza Mirhafez, Amir Avan, Alireza Pasdar, Sara Khatamianfar, Leila Hosseinzadeh, Shiva Ganjali, Ali Movahedi, Maryam Pirhoushiaran, Valentina Gómez Mellado, Domenico Rosace, Anne van Krieken, Mahdi Nohtani, Gordon A Ferns, Majid Ghayour-Mobarhan
Metabolic syndrome (MetS) is characterized by a cluster of cardiovascular risk factors that include: abdominal obesity, dyslipidaemia, hypertension, insulin resistance and impaired glucose tolerance. Recent genome wide association studies have identified several susceptibility regions involved in lipid metabolism that are also associated with MetS. We have explored the association of 9 genetic polymorphisms involved in lipid metabolism and hypertension, including: MTHFR C677T, SELE L554F, FGB - 455G>A, GNB3 C825T, ZNF259 C>G, PSRC-1 A>G, CETP I405V, LPL S447X and LPA C>T in 97 subjects with MetS and 96 individuals without MetS who were recruited randomly from Mashhad stroke and heart atherosclerotic disorder (MASHAD) study using a stratified cluster random sampling technique...
2016: International Journal of Molecular and Cellular Medicine
Fazlollah Shokri, Hamid Ghaedi, Soudeh Ghafouri Fard, Abolfazl Movafagh, Saeid Abediankenari, Abdolkarim Mahrooz, Zahra Kashi, Mir Davood Omrani
Metabolic syndrome and its pathological sequel, type 2 diabetes are considered as important global health problems. Metformin is the most common drug prescribed for patients with this disorder. Consequently, understanding the genetic pathways involved in pharmacokinetics and pharmacodynamics of this drug can have a considerable effect on the personalized treatment of type 2 diabetes. In this study, we evaluated the association between rs11212617 polymorphism of ATM gene and rs628031 of SLC22A1 gene with response to treatment in newly diagnosed type 2 diabetes patients...
2016: International Journal of Molecular and Cellular Medicine
Majid Fardaei, Shaghayegh Sarrafzadeh, Soudeh Ghafouri-Fard, Mohammad Miryounesi
Hearing loss (HL) is the most common sensory defect. Various genetic as well as environmental factors have been shown to contribute in it. More than 100 loci have been recognized to cause autosomal recessive nonsyndromic hearing loss (ARNSHL). Here, we report a 6-year old female patient with bilateral pre-lingual HL in whom a mutation has been identified in TRIOBP gene (c.6362C>T, S2121L). In silico analysis has shown that this variant is possibly pathogenic. Although several mutations have been detected in this gene in various populations, this is the first report identifying TRIOBP mutation in Iranian population...
2015: International Journal of Molecular and Cellular Medicine
Meysam Hasannejad Bibalan, Morteza Eshaghi, Javad Sadeghi, Mahla Asadian, Tahmineh Narimani, Malihe Talebi
Enterococci are Gram positive and catalase- negative cocci that are found in the gastrointestinal tract of mammals and birds, and are readily isolated from soil, surface and waters. The aim of this study was to discriminate between Enterococcus isolates based on repetitive element sequence based -PCR (Rep-PCR) with the BOXA2R primer and their antibiotics profile. Enterococci isolates were obtained from 180 fecal samples. The isolates were identified by biochemical reaction and specific identification was confirmed by PCR with species specific primers...
2015: International Journal of Molecular and Cellular Medicine
Behroz Mahdavi Poor, Jalil Rashedi, Mohammad Asgharzadeh, Esmaeel Fallah, Kareem Hatam-Nahavandi, Abdolhossein Dalimi
Cryptosporidium is one of the most common causes of childhood diarrhea in developing countries. The aim of this randomized pilot study was to detect and characterize infective species and determine the genotypes of Cryptosporidium parasites in pediatric patients suffering from diarrhea in North West of Iran. A total of 113 fecal samples were collected from diarrheic children hospitalized in Tabriz Pediatric Hospital. The amplification of small subunit ribosomal RNA gene was performed using a nested polymerase chain reaction protocol and its products were digested using two restriction enzymes for Cryptosporidium species and genotype differentiation...
2015: International Journal of Molecular and Cellular Medicine
Heshmat Shahi, Somayeh Reiisi, Rasol Bahreini, Nader Bagheri, Loghman Salimzadeh, Hedayatollah Shirzad
Helicobacter pylori (H. pylori) infection has been reported in more than half of the world human population. It is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion. IL-1β, IL-18 have been shown to contribute to H. pylori induced gastritis, but the details of inflammation and association of virulence factors remain unclear. IL-1 cytokine family has a new additional cytokine, Interleukin-33 (IL-33), which is contemplated to have an important role for host defense against microorganisms...
2015: International Journal of Molecular and Cellular Medicine
Mehdi Mahdavi, Massoumeh Ebtekar, Zuhair Mohammad Hassan, Sobhan Faezi, Hamidreza Khorram Khorshid, Morteza Taghizadeh, Keyhan Azadmanesh
Memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. The main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. Mice were immunized with human immunodeficiency virus-1 P24-Nef fusion peptide and then cellular and humoral immune responses were evaluated. In order to determine long-lived memory, immune responses were monitored for 20 weeks after final immunization. The results showed that the candidate vaccine induced proliferation and cytotoxic T lymphocyte responses and shifted cytokine patterns to T helper-1 profile...
2015: International Journal of Molecular and Cellular Medicine
Zahra Fazeli, Sayyed Mohammad Hossein Ghaderian, Masoumeh Rajabibazl, Siamak Salami, Nader Vazifeh Shiran, Mir Davood Omrani
Mesenchymal stem cells (MSCs) have the ability to differentiate into neuronal like cells under appropriate culture condition. In this study, we investigated whether MSCs derived from human peripheral blood (PB-MSCs) can differentiate into neuronal like cells by synergic effect of the growth factors EGF, bFGF and Noggin. For this purpose, the expression of five neuronal markers (Nestin, β III tubulin, NFM, MAP2 and NSE) were evaluated in treated PB-MSCs by SYBR Green Real time PCR. The expression analysis showed a higher expression of β-tubulin and NFM in treated BP-MSCs compared with untreated PB-MSCs as a control group...
2015: International Journal of Molecular and Cellular Medicine
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