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International Journal of Molecular and Cellular Medicine

Narges Kalantari, Zeinab Ahangar Darabi, Sepideh Siadati, Novin Nikbakhsh, Masoumeh Ghasemi, Taraneh Ghaffari, Salman Ghaffari, Masomeh Bayani
Breast cancer is the most prevalent malignancy in women throughout the world. Similar to other cancers, a strong relationship between breast cancer and environmental factors such as infectious agents has been reported. Toxoplasma gondii is a protozoan parasite which may play a role in cancer induction. The present study aimed to investigate a possible association between a history of T. gondii infection and breast cancer by detecting T. gondii DNA in malignant and non-malignant breast and lymph nodes tissues from breast cancer patients with latent toxoplasmosis...
2017: International Journal of Molecular and Cellular Medicine
Zohreh Khodaii, Sayyed Mohammad Hossein Ghaderian, Mahboobeh Mehrabani Natanzi
Probiotic microorganisms have attracted a growing interest for prevention and therapy of gastrointestinal disorders. Many probiotic strains have been shown to inhibit growth and metabolic activity of enteropathogenic bacteria as well as their adhesion and invasion to intestinal cells. In the present study, we evaluated the interference of bacteria-free supernatants (BFS) of cultures belonging to sixteen strains of lactobacilli and bifidobacteria , with invasion of enteroinvasive Escherichia coli (EIEC) strain, using human colonic adenocarcinoma cell lines, T84 and Caco2 cells...
2017: International Journal of Molecular and Cellular Medicine
Laura Colavita, Natalia Catalano, Giovanna Sposito, Saverio Loddo, Bruno Galletti, Carmelo Salpietro, Francesco Galletti, Caterina Cuppari
Local Allergic Rhinitis (LAR) is an emerging disease. However, its incidence in the pediatric popolution has not yet been studied. The gold standard for the diagnosis is the nasal provocation test that is not everywhere avalaible and difficult to apply in children. The aim of our study was to evaluate the nasal lavage fluid IgE as a biomarker of LAR in children. 54 pediatric patients [IQR 4.0-12.0 years] were divided into 3 groups: study group (26 children with rhinitis symptoms and without evidence of systemic atopy); allergic rhinitis (AR) group (15 children) and 13 healty controls (HC)...
2017: International Journal of Molecular and Cellular Medicine
Shewata Pandita, Deepshikha Maurya, Vijaya Ramachandran, Jyotsna Verma, Sudha Kohli, Renu Saxena, Ishwar Chander Verma
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by a significant phenotypic variability in progression of the disease. Vascular endothelial growth factor ( VEGF ) has been reported to play a major role in renal pathophysiology. The aim of the present case-control study was to evaluate the association of two promoter polymorphisms (-2578C>A and-1154G>A) of VEGF gene and ADPKD. Genotyping was carried out in 123 ADPKD patients and 100 healthy controls, using a polymerase chain reaction-restriction fragment length polymorphism technique (PCR-RFLP)...
2017: International Journal of Molecular and Cellular Medicine
Behnam Alipoor, Hamid Ghaedi, Reza Meshkani, Shahram Torkamandi, Sana Saffari, Mostafa Iranpour, Mir Davood Omrani
Although deregulation of miR-146a has been reported in type 2 diabetes repeatedly, the direction of deregulation events (up or down) remained to be inconsistent in literatures. Therefore, in this study we performed a meta-analysis on the possible association between miR-146a expression levels and type 2 diabetes. A systematic literature searching of PubMed, ISI Web of Science and Google Scholar was performed up to the end of September 2016. Finally, a total of 12 studies including 344 diabetic patients and 316 controls were selected for meta-analysis...
2017: International Journal of Molecular and Cellular Medicine
Valeria Dipasquale, Maria Concetta Cutrupi, Laura Colavita, Sara Manti, Caterina Cuppari, Carmelo Salpietro
The pathogenesis of autism spectrum disorder (ASD) likely involves genetic and environmental factors, impacting the complex neurodevelopmental and behavioral abnormalities of the disorder. Scientific research studies emerging within the past two decades suggest that immune dysfunction and inflammation have pathogenic influences through different mechanisms, all leading to both a chronic state of low grade inflammation, and alterations in the central nervous system and immune response, respectively. The high mobility group box-1 protein (HMGB1) is an inflammatory marker which has been shown to play a role in inducing and influencing neuroinflammation...
2017: International Journal of Molecular and Cellular Medicine
Ozra Tabatabaei-Malazy, Mehrnoosh Khodaeian, Fatemeh Bitarafan, Bagher Larijani, Mahsa M Amoli
Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress, a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as the main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including the polyol pathway, advanced glycation end- products formation, activation of protein kinase C isoforms, and the hexosamine pathways...
2017: International Journal of Molecular and Cellular Medicine
Mohammadreza Dehghani, Masoud Dehghan Tezerjani, Zahra Metanat, Mohammad Yahya Vahidi Mehrjardi
Anophthalmia or microphthalmia (A/M) is a rare group of congenital/developmental ocular malformations, characterized by absent or small eye within the orbit affecting one or both eyes. It has complex etiology with chromosomal, monogenic with high heterogeneity, and environmental causes. We performed genome SNP-array analysis followed by autozygosity mapping and sequencing in the members of two families in which three individuals are suffering from severe bilateral anophthalmia. The genetic analysis revealed a novel missense c...
2017: International Journal of Molecular and Cellular Medicine
Syed Tasleem Raza, Shania Abbas, Zeba Siddiqi, Farzana Mahdi
Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) and FTO (rs9939609) genes polymorphism in T2DM with dyslipidemia. Totally, 559 subjects including 221 T2DM cases with dyslipidemia, 158 T2DM without dyslipidemia and 180 controls were enrolled...
2017: International Journal of Molecular and Cellular Medicine
Harir Mohamed, Bellahcene Miloud, Fortas Zohra, José María García-Arenzana, Antonio Veloso, Susana Rodríguez-Couto
Extreme ecosystems can be a source of untapped microorganisms to produce novel bioactive compounds of industrial interest. Consequently, in this work, 32 actinomycetes were isolated from 6 soil samples collected from Algerian Sahara in searching for untapped producers of novel antimicrobial compounds. All the isolates were further subjected to antimicrobial screening against pathogenic bacteria, yeast and fungi. The obtained results indicated that three of the isolates (named C, MS1 and 10) showed antimicrobial activities against most of the tested pathogenic microorganisms...
2017: International Journal of Molecular and Cellular Medicine
Sobhan Faezi, Ahmad Reza Bahrmand, Mehdi Mahdavi, Seyed Davar Siadat, Iraj Nikokar, Soroush Sardari
Type IV pili (T4P) are major virulence factors of Pseudomonas aeruginosa (P. aeruginosa) that are associated with primary adhesion, biofilm formation and twitching motility. This study focuses on the introduction of a novel biologically active subunit vaccine derived from the disulfide loop (DSL) of P. aeruginosa pilin. We investigated the expression of the novel PilA in-frame with pET26b vector, which contains three domains, that each domain contains three tandem repeats. The flexible (GGGGS) and (GGGGS)3 linkers were linked between the three tandem repeats and each pilA domain, respectively...
2017: International Journal of Molecular and Cellular Medicine
Sajjad Mohammad Ganji, Massoud Saidijam, Razieh Amini, Seyed Habibollah Mousavi-Bahar, Nooshin Shabab, Saman Seyedabadi, Ali Mahdavinezhad
Bladder cancer is the second most common cancer in the genitourinary tract, showing often recurrence and progress into invasive states. Epigenetic changes, such as microRNA alteration are involved in bladder cancer tumorigenesis through a variety of signaling pathways. The epigenetic state depends on geographic and lifestyle conditions. The aim of this study was to investigate the expression level of microRNA-99a and microRNA-205 in bladder cancer in Iranian populations and to determine the relationship between their expressions with clinicophatological features...
2017: International Journal of Molecular and Cellular Medicine
Amr Rafat Elhamamsy, Muhammad Suleiman El Sharkawy, Ahmed Farouk Zanaty, Mohammed Ahmed Mahrous, Ahmed Ezzat Mohamed, Eslam Ahmed Abushaaban
MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional gene expression regulators. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. Recent studies have opened the way for the use of circulating miRNAs as non-invasive diagnosis and prognosis of Acute myeloid leukemia (AML). The aim of this study was to identify plasma miR-92a, miR-143 and miR-342 expression signatures in AML patients to introduce new markers for establishing AML diagnosis and prognosis...
2017: International Journal of Molecular and Cellular Medicine
Elahe Motevaseli, Ali Dianatpour, Soudeh Ghafouri-Fard
Probiotics are defined as live bacteria and yeasts that exert beneficial effects for health. Among their various effects, anti-cancer properties have been highlighted in recent years. Such effects include suppression of the growth of microbiota implicated in the production of mutagens and carcinogens, alteration in carcinogen metabolism and protection of DNA from oxidative damage as well as regulation of immune system. We performed a computerized search of the MEDLINE/PUBMED databases with key words: cancer, probiotics, lactobacilli, metastasis and invasion...
2017: International Journal of Molecular and Cellular Medicine
Javad Karimzad Hagh, Thomas Liehr, Hamid Ghaedi, Mir Majid Mossalaeie, Shohreh Alimohammadi, Faegheh Inanloo Hajiloo, Zahra Moeini, Sadaf Sarabi, Davood Zare-Abdollahi
Small supernumerary marker chromosomes (sSMC) are still a major problem in clinical cytogenetics as they cannot be identified or characterized unambiguously by conventional cytogenetics alone. On the other hand, and perhaps more importantly in prenatal settings, there is a challenging situation for counseling how to predict the risk for an abnormal phenotype, especially in cases with a de novo sSMC. Here we report on the prenatal diagnosis of a mosaic tetrasomy 18p due to presence of an sSMC in a fetus without abnormal sonographic signs...
2017: International Journal of Molecular and Cellular Medicine
Hossein Jalali, Mohammad Reza Mahdavi, Najmeh Zaeromali
Torque Teno virus (TTV) is a transfusion transmitted virus that seems to be involved in several complications such as acute respiratory diseases, liver diseases, AIDS, cancer, and autoimmune reactions. In the present study the frequency of TTV was investigated among β- thalassemia (BT) and haemodialysis (HD) patients (high risk patients for TTV) in Mazandaran province, Iran. DNA was extracted from the serum of 82 BT and 100 HD patients, and nested PCR method was applied to detect TTV DNA. The aspartate transaminase(AST) and alanine transaminase (ALT) enzyme levels in BT patients were measured using photometric assay...
2017: International Journal of Molecular and Cellular Medicine
Meysam Hasannejad Bibalan, Morteza Eshaghi, Mahdi Rohani, Mohammad Reza Pourshafie, Malihe Talebi
Lactobacillus species play a major role in gastrointestinal (GI) tract function, intestinal microbiota balance, and the immune system activity by exerting a strong activity against many intestinal pathogens. The aim of this study was to isolate Lactobacillus species from fecal samples, investigate their antimicrobial properties, and characterize their bacteriocin encoding genes. 48 fecal samples were grown in MRS broth and then MRS agar. The colonies grown in MRS agar were selected and identified by PCR. 72 Lactobacillus species were obtained from 434 lactic acid bacteria (LAB) strains...
2017: International Journal of Molecular and Cellular Medicine
Maurício Mercaldi Pastrelo, Carla Caroline Dias Ribeiro, Joselmo Willamys Duarte, Andréa Pitelli Bioago Gollücke, Ricardo Artigiani-Neto, Daniel Araki Ribeiro, Sender Jankiel Miszputen, Celina Tizuko Fujiyama Oshima, Ana Paula Ribeiro Paiotti
Reactive oxygen and nitrogen species (ROS/RNS) play a crucial role in inflammatory bowel disease (IBD) exacerbating the chronic inflammatory process. Endogenous and diet antioxidants can neutralize these compounds. The apple is widely consumed, with several antioxidant activity compounds. The present study evaluated the effects of concentrated apple extract (CAE) in acetic acid induced colitis. 29 Wistar male rats were randomized into 5 groups. G1-Sham/saline solution, G2-CAE/control, G3-acetic acid/control, G4-curative- CAE treatment and G5-preventive-CAE treatment...
2017: International Journal of Molecular and Cellular Medicine
Maryam Mafi Golchin, Sayyed Mohammad Hossein Ghaderian, Haleh Akhavan-Niaki, Rozita Jalalian, Laleh Heidari, Seyed Alireza Salami
Coronary artery disease (CAD) including myocardial infarction (MI) as its complication, is one of the most common heart diseases worldwide and also in Iran, with extremely elevated mortality. CAD is a multifactorial disorder. Twin and family studies at different loci have demonstrated that genetic factors have an important role in the progression of CAD. Many studies have reported a significant association of CDKN2B-AS, also known as ANRIL which is located within the p15, p16, p14 gene cluster at 9p21 locus, with cardiovascular diseases as well as many other diseases like diabetes and cancers...
2017: International Journal of Molecular and Cellular Medicine
Faezeh Azizi, Soraya Saleh Gargari, Sedigheh Asadi Shahmirzadi, Fatemeh Dodange, Vahid Amiri, Reza Mirfakhraie, Mir Davood Omrani
It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental non-coding RNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR...
2017: International Journal of Molecular and Cellular Medicine
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