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International Journal of Molecular and Cellular Medicine

Elham Alehabib, Javad Jamshidi, Hamid Ghaedi, Babak Emamalizadeh, Monavvar Andarva, Narsis Daftarian, Mozhgan Rezaei Kanavi, Peyman Mohammadi Torbati, Goldis Espandar, Somayeh Alinaghi, Amir Hossein Johari, Mansoor Saghally, Fatemeh Mohajerani, Hossein Darvish
In the current study, we conducted a mutation screening of tumor-associated calcium signal transducer 2 ( TACSTD2 ) gene in six consanguineous Iranian families with gelatinous drop-like corneal dystrophy (GDLD), in order to find the causative mutations. Detailed eye examination was performed by ophthalmologist to confirm GDLD in patients. To detect the possible mutations, direct Sanger sequencing was performed for the only exon of TACSTD2 gene, and its boundary regions in all patients. In the patients with GDLD, the corneal surface showed lesions with different shapes from mild to severe forms depending on the progress of the disease...
2017: International Journal of Molecular and Cellular Medicine
Zahra Ousati Ashtiani, Gholamreza Pourmand, Seyed Alireza Salami, Mohsen Ayati, Javad Tavakkoly-Bazzaz
Long intergenic non-coding RNA (lincRNA) has been introduced as key regulators of diverse biological processes, including transcription, chromatin organization, cell growth and tumorigenesis. With regard to the potential role of lincRNAs in cancer development, one may postulate that differential expression of lincRNAs could be employed as a tool in cancer diagnosis, prognosis, and targeted therapy. In this study, we aimed to explore the putative correlation between the expression levels of two lincRNAs: LINC00152 and LINC01082 in the bladder cancer (BC), in comparison with its adjacent non-cancerous tissue...
2017: International Journal of Molecular and Cellular Medicine
Nasrin Malekpour, Seyed Mohammad Amin Kormi, Mahtab Azadbakht, Meysam Yousefi, Mohammad Hasanzadeh-Nazar Abadi
Robertsonian translocations (RBTs) are associated with an increased risk of aneuploidy. Single RBT carriers are the most common balanced rearrangements among the carrier couples with the history of spontaneous abortions. However, double Robertsonian translocations (DRBTs), in which two balanced RBTs occur simultaneously, are extremely rare conditions. A 9-year-old mentally normal girl with multiple skeletal disorders was found to carry a balanced 13/14 RBT (45, XX, t(13q; l4q)). Three generations of her family, including her parents and her maternal grandparents were investigated for cytogenetic analysis...
2017: International Journal of Molecular and Cellular Medicine
Sameen Afzal, Samina Zaman
Mature cystic teratoma (MCT) is the most common type of ovarian germ cell tumor occurring in females of reproductive age. It is typically benign, but rare malignant transformations have been reported in 1-2% of the cases. Among a wide variety of malignancies arising in MCTs, high grade lymphomas are the least common. We present a case of a 45- years -old female with a unilateral adnexal mass. Gross examination revealed a unilocular cyst with a smooth and intact capsule. The cyst lumen was filled with sebaceous material and hair...
2017: International Journal of Molecular and Cellular Medicine
Shahram Torkamandi, Milad Bastami, Hamid Ghaedi, Shahriar Tarighi, Fazlollah Shokri, Abdolreza Javadi, Reza Mirfakhraie, Mir Davood Omrani
Type 2 diabetes mellitus (T2DM) is one of the most common multifactorial disorders in Iran. Recent genome wide association studies (GWASs) and functional studies have suggested that WFS1 may predispose individuals to T2DM. However, to date, the possible association of such variants with T2DM in Iranians remained unknown. Here, we investigated the association of the two polymorphisms of WFS1 (rs1801214 a CpG-SNP, and rs1046320 a 3'UTR-SNP) with T2DM in an Iranian population. The study population comprised 432 unrelated Iranian individuals including 220 patients with T2DM, and 211 unrelated healthy control subjects...
2017: International Journal of Molecular and Cellular Medicine
Severyn Myronovskij, Olga Shalay, Veronika Spivak, Rostyslav Stoika, Yuriy Kit
No abstract text is available yet for this article.
2017: International Journal of Molecular and Cellular Medicine
Fatemeh Nedaei, Zahra Noormohammadi, Saied Reza Naddaf, Somayeh Mohammadi, Ahmad Reza Esmaeili Rastaghi
Plasmodium vivax apical membrane antigen-1(PvAMA-1) is a surface protein with polymorphic sites. This study was aimed to analyze the polymorphic amino acid residues at PvAMA-1 in different infected age groups. 92 blood samples were collected from the south and southeast of Iran. The DNA coding for the domain I (DI), DII, and partial DIII of this antigen was amplified by Nested-PCR, and sequenced. Nucleotide mutations were found in 49 sites and based on the amino acid sequence, 30 variable sites were detected...
2017: International Journal of Molecular and Cellular Medicine
Narges Kalantari, Zeinab Ahangar Darabi, Sepideh Siadati, Novin Nikbakhsh, Masoumeh Ghasemi, Taraneh Ghaffari, Salman Ghaffari, Masomeh Bayani
Breast cancer is the most prevalent malignancy in women throughout the world. Similar to other cancers, a strong relationship between breast cancer and environmental factors such as infectious agents has been reported. Toxoplasma gondii is a protozoan parasite which may play a role in cancer induction. The present study aimed to investigate a possible association between a history of T. gondii infection and breast cancer by detecting T. gondii DNA in malignant and non-malignant breast and lymph nodes tissues from breast cancer patients with latent toxoplasmosis...
2017: International Journal of Molecular and Cellular Medicine
Zohreh Khodaii, Sayyed Mohammad Hossein Ghaderian, Mahboobeh Mehrabani Natanzi
Probiotic microorganisms have attracted a growing interest for prevention and therapy of gastrointestinal disorders. Many probiotic strains have been shown to inhibit growth and metabolic activity of enteropathogenic bacteria as well as their adhesion and invasion to intestinal cells. In the present study, we evaluated the interference of bacteria-free supernatants (BFS) of cultures belonging to sixteen strains of lactobacilli and bifidobacteria , with invasion of enteroinvasive Escherichia coli (EIEC) strain, using human colonic adenocarcinoma cell lines, T84 and Caco2 cells...
2017: International Journal of Molecular and Cellular Medicine
Laura Colavita, Natalia Catalano, Giovanna Sposito, Saverio Loddo, Bruno Galletti, Carmelo Salpietro, Francesco Galletti, Caterina Cuppari
Local Allergic Rhinitis (LAR) is an emerging disease. However, its incidence in the pediatric popolution has not yet been studied. The gold standard for the diagnosis is the nasal provocation test that is not everywhere avalaible and difficult to apply in children. The aim of our study was to evaluate the nasal lavage fluid IgE as a biomarker of LAR in children. 54 pediatric patients [IQR 4.0-12.0 years] were divided into 3 groups: study group (26 children with rhinitis symptoms and without evidence of systemic atopy); allergic rhinitis (AR) group (15 children) and 13 healty controls (HC)...
2017: International Journal of Molecular and Cellular Medicine
Shewata Pandita, Deepshikha Maurya, Vijaya Ramachandran, Jyotsna Verma, Sudha Kohli, Renu Saxena, Ishwar Chander Verma
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by a significant phenotypic variability in progression of the disease. Vascular endothelial growth factor ( VEGF ) has been reported to play a major role in renal pathophysiology. The aim of the present case-control study was to evaluate the association of two promoter polymorphisms (-2578C>A and-1154G>A) of VEGF gene and ADPKD. Genotyping was carried out in 123 ADPKD patients and 100 healthy controls, using a polymerase chain reaction-restriction fragment length polymorphism technique (PCR-RFLP)...
2017: International Journal of Molecular and Cellular Medicine
Behnam Alipoor, Hamid Ghaedi, Reza Meshkani, Shahram Torkamandi, Sana Saffari, Mostafa Iranpour, Mir Davood Omrani
Although deregulation of miR-146a has been reported in type 2 diabetes repeatedly, the direction of deregulation events (up or down) remained to be inconsistent in literatures. Therefore, in this study we performed a meta-analysis on the possible association between miR-146a expression levels and type 2 diabetes. A systematic literature searching of PubMed, ISI Web of Science and Google Scholar was performed up to the end of September 2016. Finally, a total of 12 studies including 344 diabetic patients and 316 controls were selected for meta-analysis...
2017: International Journal of Molecular and Cellular Medicine
Valeria Dipasquale, Maria Concetta Cutrupi, Laura Colavita, Sara Manti, Caterina Cuppari, Carmelo Salpietro
The pathogenesis of autism spectrum disorder (ASD) likely involves genetic and environmental factors, impacting the complex neurodevelopmental and behavioral abnormalities of the disorder. Scientific research studies emerging within the past two decades suggest that immune dysfunction and inflammation have pathogenic influences through different mechanisms, all leading to both a chronic state of low grade inflammation, and alterations in the central nervous system and immune response, respectively. The high mobility group box-1 protein (HMGB1) is an inflammatory marker which has been shown to play a role in inducing and influencing neuroinflammation...
2017: International Journal of Molecular and Cellular Medicine
Ozra Tabatabaei-Malazy, Mehrnoosh Khodaeian, Fatemeh Bitarafan, Bagher Larijani, Mahsa M Amoli
Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress, a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as the main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including the polyol pathway, advanced glycation end- products formation, activation of protein kinase C isoforms, and the hexosamine pathways...
2017: International Journal of Molecular and Cellular Medicine
Mohammadreza Dehghani, Masoud Dehghan Tezerjani, Zahra Metanat, Mohammad Yahya Vahidi Mehrjardi
Anophthalmia or microphthalmia (A/M) is a rare group of congenital/developmental ocular malformations, characterized by absent or small eye within the orbit affecting one or both eyes. It has complex etiology with chromosomal, monogenic with high heterogeneity, and environmental causes. We performed genome SNP-array analysis followed by autozygosity mapping and sequencing in the members of two families in which three individuals are suffering from severe bilateral anophthalmia. The genetic analysis revealed a novel missense c...
2017: International Journal of Molecular and Cellular Medicine
Syed Tasleem Raza, Shania Abbas, Zeba Siddiqi, Farzana Mahdi
Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) and FTO (rs9939609) genes polymorphism in T2DM with dyslipidemia. Totally, 559 subjects including 221 T2DM cases with dyslipidemia, 158 T2DM without dyslipidemia and 180 controls were enrolled...
2017: International Journal of Molecular and Cellular Medicine
Harir Mohamed, Bellahcene Miloud, Fortas Zohra, José María García-Arenzana, Antonio Veloso, Susana Rodríguez-Couto
Extreme ecosystems can be a source of untapped microorganisms to produce novel bioactive compounds of industrial interest. Consequently, in this work, 32 actinomycetes were isolated from 6 soil samples collected from Algerian Sahara in searching for untapped producers of novel antimicrobial compounds. All the isolates were further subjected to antimicrobial screening against pathogenic bacteria, yeast and fungi. The obtained results indicated that three of the isolates (named C, MS1 and 10) showed antimicrobial activities against most of the tested pathogenic microorganisms...
2017: International Journal of Molecular and Cellular Medicine
Sobhan Faezi, Ahmad Reza Bahrmand, Mehdi Mahdavi, Seyed Davar Siadat, Iraj Nikokar, Soroush Sardari
Type IV pili (T4P) are major virulence factors of Pseudomonas aeruginosa (P. aeruginosa) that are associated with primary adhesion, biofilm formation and twitching motility. This study focuses on the introduction of a novel biologically active subunit vaccine derived from the disulfide loop (DSL) of P. aeruginosa pilin. We investigated the expression of the novel PilA in-frame with pET26b vector, which contains three domains, that each domain contains three tandem repeats. The flexible (GGGGS) and (GGGGS)3 linkers were linked between the three tandem repeats and each pilA domain, respectively...
2017: International Journal of Molecular and Cellular Medicine
Sajjad Mohammad Ganji, Massoud Saidijam, Razieh Amini, Seyed Habibollah Mousavi-Bahar, Nooshin Shabab, Saman Seyedabadi, Ali Mahdavinezhad
Bladder cancer is the second most common cancer in the genitourinary tract, showing often recurrence and progress into invasive states. Epigenetic changes, such as microRNA alteration are involved in bladder cancer tumorigenesis through a variety of signaling pathways. The epigenetic state depends on geographic and lifestyle conditions. The aim of this study was to investigate the expression level of microRNA-99a and microRNA-205 in bladder cancer in Iranian populations and to determine the relationship between their expressions with clinicophatological features...
2017: International Journal of Molecular and Cellular Medicine
Amr Rafat Elhamamsy, Muhammad Suleiman El Sharkawy, Ahmed Farouk Zanaty, Mohammed Ahmed Mahrous, Ahmed Ezzat Mohamed, Eslam Ahmed Abushaaban
MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional gene expression regulators. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. Recent studies have opened the way for the use of circulating miRNAs as non-invasive diagnosis and prognosis of Acute myeloid leukemia (AML). The aim of this study was to identify plasma miR-92a, miR-143 and miR-342 expression signatures in AML patients to introduce new markers for establishing AML diagnosis and prognosis...
2017: International Journal of Molecular and Cellular Medicine
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