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Current Health Sciences Journal

O Rogoveanu, D Kamal, C T Streba, R Trăistaru
Purpose - The evaluation of the ventilation function improval in patients with ankylosing spondylitis following the medical recovery procedures. Methods - The study included 24 patients that were diagnosed with AS stages I and IV that were monitored for 24 months. We recorded ventilation functional tests, respiratory gas levels, thorax involvement in inspiration and expiration, the medical, physical and balneotherapy that they had followed. The activity of the disease was evaluated using the BASDAI score. The evaluation of the functional disability was based on the BASFI score and the life quality needed the QLQ questionnaire...
October 2015: Current Health Sciences Journal
A Osman, M S Ciolofan, E Ioniță, I Ioniță, F Anghelina, C A Mogoantă, A S Enescu, A Enescu, M Toader
The basaloid carcinoma is a rare and distinct type of squamous carcinoma. Of all the squamous carcinomas, the basaloid tumor is noted for its high aggressivity and fast replication rate. It is usually discovered within the upper levels of the larynx (supraglottis), the tongue base or the piriform sinuses in male patients ranging from sixty to eighty years old. The aggressivity of the tumor also means its discovery is usually a late event thus associating a relatively low survival rate within the first 5 years...
October 2015: Current Health Sciences Journal
D A Cherata, D Cârstea, M Zaharie, C Bătăiosu, D Lungulescu
Cardiotoxicity is the most important side effect of cancer therapy resulting in increased patient morbidity and mortality, therefore understanding its occurrence mechanism and a correct and early diagnosis are essential for patients at risk of irreversible heart failure. We present the case of a patient who developed cancer therapeutics-related cardiac dysfunction, emphasizing the importance of regular echocardiographic evaluation for early detection of subclinical cardiac dysfunction and further cardiac monitoring...
October 2015: Current Health Sciences Journal
I Cherciu, T Cartana, I Streata, M Ioana, A Săftoiu
Rectal cancer is one of the most common diagnosed malignancies in the world. We present the case of a 54 years old patient, diagnosed with adenocarcinoma of the rectum and unsuccessful treatment. The possible involvement of cancer stem cells in tumor relapse and treatment failure represents the motivation behind an extensive imaging evaluation. The aim of our case report was to assess the outcome of rectal cancer assessment using standard and state-of-the-art techniques, including evaluation of colorectal cancer stem cells...
October 2015: Current Health Sciences Journal
M A Dobrescu, G Chelu, D E Tache, S O Purcaru, I O Petrescu
Limb Girdle Muscular Dystrophy 2A (LGMD 2A) is the most common form of limb girdle muscular dystrophies caused by mutations in the calpain-3 gene (CAPN-3). The pattern of LGMD 2A can be clinically indistinguishable from that of Duchenne Muscular Dystrophy (DMD). We report a case of a 14-year-old boy which has the initial diagnosed as DMD at 6 years old, based on clinical features and very elevated serum creatine kinase levels. A muscle biopsy at the age of 10 showed atypical features which suggested a histiocytosis or neural damage...
October 2015: Current Health Sciences Journal
A M Kamal, P Mitruț, C K Kamal, D O Alexandru, A Tica
Sarcoidosis is a chronic inflammatory systemic disorder of unknown etiology. It is known to be triggered by an autoimmune process, and is currently recognized as a rare adverse event to interferon therapy for Hepatitis C Virus Infection. Clinical presentation of interferon-triggered sarcoidosis is varied, but ocular manifestation as a first symptom was only once, previously reported. We report the case of a 32 year old woman, infected with hepatitis C, for whom antiviral therapy was initiated. Prior to treatment, the patient had outstanding medical history...
October 2015: Current Health Sciences Journal
A F Rosu, C Freitas, R T Marinho, J Velosa
The statistics proved that approximately 25% of the patients with acute HCV present with jaundice, and only 10-20% develop gastrointestinal symptoms. We present the case of a 58 year-old woman, with prior antecedents of arterial hypertension and diabetes mellitus since 25 years old, hypercholesterolemia and hypertriglyceridemia, psoriasis, epilepsy and depressive syndrome. She clinically presents asthenia, anorexia, itching, jaundice and choluria. The objective examination showed an orientated patient, without flapping, hemorrhagic dyscrasia or signs of chronic hepatic disease, with icteric mucosa and skin, abdominal pain, with hepatomegaly and splenomegaly...
October 2015: Current Health Sciences Journal
A A Stănescu
PURPOSE: The aim of the study was to evaluate the concentration - in-vitro release relationship for topical semisolid formulations of sodium cromoglycate. Materials / Methods. According to usual pharmaceutical compounding practice, commercially available cosmetic emulsions were used as vehicles for topical semisolid dosage forms containing 0.5, 2, 4 and 10% disodium cromoglycate (CS). The in-vitro release profiles and structural parameters of the resulting formulations was evaluated in a correlated manner, in order to reveal potential differences in the in-vivo performance...
October 2015: Current Health Sciences Journal
V V Gheorman, A L Chirita, M Dumitrescu, R Stanescu, I Rogoveanu
The study of chronic viral hepatitis represents a real challenge for modern medicine. If we also analyze this illness from the point of the mental changes involved, the complexity of the study increases. To the etiological, symptomatological polymorphism, alongside the paraclinical and conduct diagnosis, there may be easily added the multitude of mental disorders. The authors have tried, through this paper, to draw the attention upon the importance of studying certain mental disorders connected to a somatic disease, each and every representing a distinct entity, but which together may reach a remarkable complexity...
October 2015: Current Health Sciences Journal
D G Iliescu, S Tudorache, M L Cara, R Dragusin, O Carbunaru, M Florea, C Patru, L Zorila, A Dragoescu, L Novac, N Cernea
OBJECTIVES: To assess the acceptability of intrapartum ultrasound (IPUS) labor monitoring in unselected Romanian women attending a tertiary maternity unit and the patients' experience of the examination (i.e. the perceived difficulty regarding the evaluation protocol). METHODS: The research was a prospective longitudinal observational study on unselected low-risk women that delivered in our unit. IPUS monitoring of active labor was proposed for observational purposes in low-risk population...
October 2015: Current Health Sciences Journal
R M Pleșea, M S Șerbănescu, D O Alexandru, V Ciovică, A Stoiculescu, O T Pop, C Simionescu, I E Pleșea
PURPOSE: The study aims to assess the correlation between stromal fibrillary component (SFC) and vascular density (VD) in Gleason architectural patterns of prostate carcinoma. MATERIALS AND METHODS: 680 digital images of prostate adenocarcinoma labeled following both Gleason and Srigley systems were acquired with X20 objective from serial sections, one stained using Gömöri technique for SFC and one immunomarked with anti-CD34 antibody for vessels. The SFC amount and VD were determined and compared...
October 2015: Current Health Sciences Journal
R M Folcuti, I Silosi, S O Purcaru, D E Tache, A M Georgescu, G H Emami, A Dricu
A novel target for cancer treatment is based on the effects of non-tumor cells, including hMSCs on tumor growth. However, the results are controversial: some studies showed that hMSCs inhibit tumor progression, while others found they promote tumor cell proliferation. In this study, we analyse the effect of human mesenchymal cells derived from umbilical cord tissue (hUC-MSCs) and bone-marrow- mesenchymal stem cells (hBM-MSCs) on glioblastoma cells viability in vitro. GB cell cultures were established from fresh sample tissues provided by "Bagdasar-Arseni" Hospital, Bucharest, from consented GB patients...
October 2015: Current Health Sciences Journal
B S Ungureanu, C Margaritescu, D Pirici, I A Gheonea, N F Trincu, A Fifere, D R Tudorascu, A Saftoiu
Iron oxide nanoparticles (IONs) are of great interest in medicine, with great potential for imaging diagnostics, as well as therapeutic. Biomedical applications of IONs have been suggested for magnetic resonance imaging (MRI), with two available contrast agents on the market. However, new developments in biocompatibility and biodistribution are necessary as many new physiochemical features of coatings have been proposed for a good safety profile. MATERIALS AND METHODS: Our study objective was to assess a different setting in terms of biodistribution of IONs coated with citric acid on an experimental pig model, based on EUS-guided portal vein (PV) injection...
October 2015: Current Health Sciences Journal
S O Purcaru, D E Tache, F Serban, R M Folcuti, A M Georgescu, P O Stovicek, M M Danciulescu, L G Tataranu, A Dricu
Resistance to targeted therapy is a well known obstacle in cancer therapy. The cross-talk between several growth factor receptors generates redundancy in their intracellular pathways that usually mediates resistance to receptor targeted therapy. Simultaneous inactivation of two or more growth factor receptors has been suggested to prevent the cross-talk between their signaling pathways and to better eliminate malignant cells. Here we found that targeted therapy against these receptors induced moderate cell death in glioblastoma cells...
October 2015: Current Health Sciences Journal
C F Jieanu, B S Ungureanu, D L Sandulescu, D O Alexandru, G S Firu, D I Gheonea, I Rogoveanu, S Cazacu, C Ciurea, A Saftoiu
Fibrosis assessment is a necessary component of liver disease evaluation not only for prognosis but also for future therapeutic management. Our study objective was to evaluate the accuracy of quantitative assessment of liver fibrosis in patients with chronic viral hepatitis B or C, relying on RTSE results, a method approved and acknowledged in Europe. MATERIAL AND METHODS: Sixty-three consecutive patients diagnosed with chronic viral hepatitis B or C between January 2014 and December 2014 at the Emergency County Hospital of Craiova were enrolled in the study...
October 2015: Current Health Sciences Journal
F Ciulu-Costinescu, J Neamţu, M Popescu, L Chirigiu, A Simionescu, M V Bubulică, I Belu
The aim of this study was to investigate Capsicum Annuum L. ultrasonicated extracts and dry powder. The percentage of water, dry matter and ash were determined. FT-IR analysis confirmed the presence of important classes of secondary metabolites in the extracts and by GC-MS a large number of important pharmaceutical compounds were identified, including capsaicin.
October 2015: Current Health Sciences Journal
D N Florescu, D R Tudoraşcu, F Burada, M G Cucu, M E Ciurea
PURPOSE: Our study aimed to assess a possible correlation between NOD2 Arg702Trp (rs2066844) polymorphism and gastric cancer risk in a Romanian population. MATERIAL/METHODS: A total of 322 subjects (72 patients with gastric adenocarcinoma and 250 healthy controls) were included. Genomic DNA was extracted from blood leukocytes and NOD2 Arg702Trp polymorphism was genotyped by Real-Time PCR using specific TaqMan probes. RESULTS: No statistically significant difference was observed between gastric cancer patients and controls when we compared one genotype with other genotype (the CC genotype serves as reference) (OR 0...
October 2015: Current Health Sciences Journal
N F Trincu, T A Balșeanu, B S Ungureanu, A Fifere, I Pirici, A Săftoiu, J Neamțu
Superparamagnetic iron oxide nanoparticles are primarily utilized for different biomedical applications such as magnetic resonance imaging (MRI), hyperthermia, cancer treatment, targeted delivery of drugs or genes and biosensors. Nanoparticles are interesting due to their unique proprieties together with minor side effects. It is essential to determine the blood clearance of superparamagnetic nanoparticles (SPIONs) for in vivo biomedical applications, to ensure their optimum clinical use. The purpose of this study was to evaluate the elimination kinetic of citric-acid iron oxide nanoparticles in blood via intravenous injection in rats...
October 2015: Current Health Sciences Journal
A M Amzolini, M Fortofoiu, S E Tudorica-Micu, M C Fortofoiu, D Neagoe, M Popescu, F Burada, C C Vere, T Ciurea
PURPOSE: The aim of our study was to identify the possible involvement of adiponutrine polymorphysm and of human leukocyte antigens (HLA) in the development of non-alcoholic fatty liver disease (NAFLD). MATERIAL AND METHODS: We included in this study a total of 138 subjects with non-invasive diagnosis of non-alcoholic hepatic steatosis. The patatin-like phospholipase domain containing protein 3 (PNPLA3) rs738409 (adiponutrine) polymorphism was genotyped by allelic discrimination TaqMan PCR assay (5' nuclease assay), using predesigned TaqMan SNP Genotyping Assays...
October 2015: Current Health Sciences Journal
A Ciocâlteu, D Pirici, A Stefanescu, C V Georgescu, V Şurlin, A Săftoiu
The aim of this case report was to evaluate the feasibility of in vivo acquisition of microscopic images using fluorescent CD105 antibodies for molecular imaging in human colorectal cancer. After excluding the presence of tissue autofluorescence, the antibody solution was topically administered through a spray-catheter. The targeted area was analyzed by eCLE and images were recorded. The fractal dimension of tumor vessels and the vessel density were determined using ImageJ software. Immunohistochemistry was used as a gold standard...
July 2015: Current Health Sciences Journal
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