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https://www.readbyqxmd.com/read/28331841/resistance-testing-for-the-treatment-of-chronic-hepatitis-c-with-direct-acting-antivirals-when-and-for-how-long
#1
Ana Belén Pérez, Natalia Chueca, Federico García
The need to test for resistance associated substitutions (RAS) has been intensively debated in the past two years. In the absence of pangenotypic combinations, it seems reasonable that, if available, RAS testing in the NS5A gene at baseline for genotypes 1a and 3 may help to avoid overtreatment in terms of ribavirin usage and/or prolonged treatment duration. When patients fail treatment, RAS testing may also be useful to guide the selection of the new regimen, especially for those that need urgent retreatment and that have failed a combination including an NS5A inhibitor...
March 2017: Germs
https://www.readbyqxmd.com/read/28331840/consensus-statement-on-the-management-of-patients-with-hcv-infection-in-romania
#2
REVIEW
(no author information available yet)
BACKGROUND: HCV direct-acting antivirals (DAAs) have made treatment easier for both patients and healthcare practitioners, but have also brought new challenges in terms of patient management and monitoring prior to, during, and after treatment. METHODS: To sum up and unify the clinical experience of Romanian DAA prescribing physicians, we have organized a Consensus Meeting in November 2016 in Bucharest, Romania. CONSENSUS STATEMENT: The Consensus Meeting has provided expert answers to ten significant questions regarding HCV infection, namely: How do we diagnose patients with HCV infection? How do we stage liver disease in patients with HCV infection? How do we monitor patients with HCV infection prior to treatment? Which patients with HCV infection do we treat? When do we start treatment for HCV infection? What regimens do we use for treating HCV infection? How do we monitor patients with HCV infection during treatment? What adverse events should we expect during treatment of HCV infection and how do we prevent/manage them? How do we monitor patients with HCV infection after treatment? How do we expect the landscape of HCV to change in the following years? ...
March 2017: Germs
https://www.readbyqxmd.com/read/28331839/enterococcal-meningitis-in-association-with-strongyloides-hyperinfection-syndrome
#3
Kalpesh S Sukhwani, Nitin Bansal, Mamta Soni, Anand Ramamurthy, Ram Gopalakrishnan
INTRODUCTION: Strongyloidiasis can cause hyperinfection or disseminated infection in an immunocompromised host, and is an important factor linked to enterococcal bacteremia and meningitis. CASE REPORTS: We report two cases highlighting the importance of suspecting Strongyloides hyperinfection syndrome in patients with enterococcal meningitis. CONCLUSION: Our cases highlight the importance of suspecting Strongyloides hyperinfection syndrome in cases of community acquired enterococcal bacteremia and meningitis...
March 2017: Germs
https://www.readbyqxmd.com/read/28331838/bibliometric-analysis-of-literature-on-antifungal-triazole-resistance-1980-2015
#4
Waleed M Sweileh, Ansam F Sawalha, Samah Al-Jabi, Sa'ed H Zyoud
BACKGROUND: Triazole antifungal agents play an important role in the treatment of a wide range of fungal infections. Little is known about antifungal triazole drug resistance when compared to antibiotic resistance. Therefore, this study was carried out to give a bibliometric overview of literature on triazole antifungal drug resistance. METHODS: Keywords related to triazole drug class and resistance were used in a search query in the Scopus search engine. The time span was set from 1980 to 2015...
March 2017: Germs
https://www.readbyqxmd.com/read/28331837/public-health-relevance-of-non-tuberculous-mycobacteria-among-afb-positive-sputa
#5
Prabha Desikan, Karuna Tiwari, Nikita Panwalkar, Saima Khaliq, Manju Chourey, Reeta Varathe, Shaina Beg Mirza, Arun Sharma, Sridhar Anand, Manoj Pandey
BACKGROUND: Sputum smear microscopy for acid fast bacilli (AFB) is used by most public health programmes to detect tuberculosis. While most AFB in countries endemic for tuberculosis are Mycobacterium tuberculosis (MTB), some may also be non-tuberculous mycobacteria (NTM). The inability to differentiate NTM from MTB by sputum smear microscopy may lead to erroneous diagnoses of tuberculosis, leading in turn to inappropriate therapy. METHODS: This was a retrospective study of consecutive sputum samples received from November 2013 to March 2015 in the Department of Microbiology, Bhopal Memorial Hospital & Research Centre, Bhopal, India...
March 2017: Germs
https://www.readbyqxmd.com/read/28331836/cepi-a-global-partnership
#6
EDITORIAL
Richard B Roberts
No abstract text is available yet for this article.
March 2017: Germs
https://www.readbyqxmd.com/read/28053918/pulmonary-localization-of-mansonella-perstans-in-a-16-months-old-male-patient-in-a-tertiary-care-hospital-in-bukavu-democratic-republic-of-congo
#7
Landry Kabego, Joe Bwija Kasengi, Patrick Mirindi, Vurayai Ruhanya, David Lupande, André Bulabula, Patrick Ngoma
INTRODUCTION: Mansonella perstans is a human filarial parasite transmitted by biting midges (Diptera: Ceratopogonidae) belonging to the genus Culicoides and it is widely spread in sub-Saharan Africa. While most cases are asymptomatic, mansonelliasis can be associated with angioedema, arthralgia, swellings, pain in the scrotum or in serous cavities such as the pleura, the peritoneum, the pericardium, etc. Mansonelliasis can be really hard to treat, but it has been shown that an intensive treatment using albendazole can clear the parasite...
December 2016: Germs
https://www.readbyqxmd.com/read/28053916/urinary-tract-infections-a-retrospective-descriptive-study-of-causative-organisms-and-antimicrobial-pattern-of-samples-received-for-culture-from-a-tertiary-care-setting
#8
Bhuvanesh Sukhlal Kalal, Savitha Nagaraj
INTRODUCTION: Urinary tract infections (UTI) are common infections encountered by physicians either on an outpatient or inpatient basis. These infections have taken center stage due to increasing resistance being reported for commonly used antibiotics. Understanding the distribution and antibiotic susceptibility patterns of uropathogens would facilitate appropriate therapy. METHODS: A retrospective analysis of the culture isolates obtained from urine samples received at the Department of Microbiology, St...
December 2016: Germs
https://www.readbyqxmd.com/read/28053915/frequency-of-mutations-in-rifampicin-and-isoniazid-resistant-isolates-of-m-tuberculosis-an-analysis-from-central-india
#9
Prabha Desikan, Atul Kharate, Nikita Panwalkar, Jyoti Khurana, Shaina Beg Mirza, Aparna Chaturvedi, Reeta Varathe, Manju Chourey, Pradeep Kumar, Nitin Doshi, Manoj Pandey
BACKGROUND: The spread of drug-resistant tuberculosis has challenged tuberculosis control strategies globally. The present study aims to analyze the frequency of mutations in rpoB, katG and inhA genes in strains of M. tuberculosis complex (MTBC) circulating in Central India. It is anticipated that the findings may provide a starting point to understand the evolutionary success of drug-resistant strains of MTBC in this region. METHODS: Line probe assay was carried out on 720 consecutive sputum samples of MDR suspects from June 2012 to May 2013...
December 2016: Germs
https://www.readbyqxmd.com/read/28053914/resistance-to-direct-antiviral-agents-for-hepatitis-c-virus-infection-impact-on-clinical-practice
#10
EDITORIAL
Ana Belén Pérez, Federico García
No abstract text is available yet for this article.
December 2016: Germs
https://www.readbyqxmd.com/read/27622163/spondylodiscitis-and-bacteremia-due-to-staphylococcus-hyicus-in-an-immunocompetent-man
#11
Maud Foissac, Maria Lekaditi, Bouchra Loutfi, Agnès Ehrhart, Frédéric-Antoine Dauchy
INTRODUCTION: Staphylococcus hyicus is a coagulase-variable Staphylococcus spp. well-known by veterinarians since it is the major agent of a severe cutaneous infection in piglets called exudative epidermitis. In other species the symptoms of infection are quite different. Human cases are uncommon but seem to occur more frequently after repeated contacts with farm animals. CASE REPORT: We report the case of a 58-year-old man suffering from debilitating subacute lumbar pain, in whom diagnosis of infectious spondylodiscitis was based on spine MRI and positive microbiological results...
September 2016: Germs
https://www.readbyqxmd.com/read/27622162/rotavirus-gastroenteritis-in-children-less-than-five-years-of-age-in-primary-care-settings-in-bulgaria-an-observational-study
#12
Mayda Tiholova, Kusuma Gopala, Magda Berberova, Margarita Strokova-Stoilova, Monica Tafalla
BACKGROUND: Rotavirus (RV) causes a high proportion of acute gastroenteritis (AGE) cases, especially among children under the age of five years old. This surveillance study was undertaken to study the incidence and severity of rotavirus gastroenteritis (RVGE) in primary care settings in Bulgaria over a one-year period. METHODS: In this prospective, observational study of AGE cases in children under five years of age presenting in the primary care setting over a one year period, stool samples were collected and tested for RV using a rapid visual immunochromatographic test kit...
September 2016: Germs
https://www.readbyqxmd.com/read/27622161/prevalence-virulence-and-antimicrobial-resistance-patterns-of-aeromonas-spp-isolated-from-children-with-diarrhea
#13
Mohammad Mehdi Soltan Dallal, Ramin Mazaheri Nezhad Fard, Morteza Kavan Talkhabi, Leyla Aghaiyan, Zohre Salehipour
BACKGROUND: Aeromonas spp. cause various intestinal and extraintestinal diseases. These bacteria are usually isolated from fecal samples, especially in children under five years old. The aim of this study was to assess the prevalence of Aeromonas spp. and their antimicrobial resistance profile in children with diarrhea referred to the Children Medical Center in Tehran, between 2013 and 2014. METHODS: A total number of 391 stool samples were collected from children with ages between 1 day and 14 years old, with diarrhea (acute or chronic), referred to the Children Hospital, Tehran, Iran, between 2013 and 2014...
September 2016: Germs
https://www.readbyqxmd.com/read/27622160/syphilis-on-the-rise-a-prolonged-syphilis-outbreak-among-hiv-infected-patients-in-northern-greece
#14
Olga Tsachouridou, Lemonia Skoura, Eirini Christaki, Panagiotis Kollaras, Eleni Sidiropoulou, Pantelis Zebekakis, Efstratios Vakirlis, Apostolia Margariti, Symeon Metallidis
INTRODUCTION: Sexually transmitted diseases (STDs) are a major public health issue in Europe. Numerous outbreaks of syphilis have been described recently and an increased prevalence of high-risk sexual practices has raised concern about the transmission of HIV and other STDs. Similarly, an increase in sexually transmitted infections has been recorded in Northern Greece. METHODS: This report describes a recent outbreak of syphilis in people living with HIV. The demographic, clinical, and serologic data of HIV patients diagnosed with syphilis were recorded and analyzed...
September 2016: Germs
https://www.readbyqxmd.com/read/27622159/the-transition-from-co-morbidities-to-geriatric-syndromes-in-hiv
#15
EDITORIAL
Giovanni Guaraldi
No abstract text is available yet for this article.
September 2016: Germs
https://www.readbyqxmd.com/read/27482516/nearing-elimination-of-meningitis-a-from-the-african-meningitis-belt-using-meningococcal-a-conjugate-vaccine
#16
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava, Jegadeesh Ramasamy
No abstract text is available yet for this article.
June 2016: Germs
https://www.readbyqxmd.com/read/27482515/diagnostic-value-of-sputum-adenosine-deaminase-ada-level-in-pulmonary-tuberculosis
#17
Fariba Binesh, Hadi Jalali, Mohammad Reza Zare, Farhad Behravan, Arefeh Dehghani Tafti, Fatemah Behnaz, Mohammad Tabatabaee, Seyed Hossein Shahcheraghi
INTRODUCTION: Tuberculosis is still a considerable health problem in many countries. Rapid diagnosis of this disease is important, and adenosine deaminase (ADA) has been used as a diagnostic test. The aim of this study was to assess the diagnostic value of ADA in the sputum of patients with pulmonary tuberculosis. METHODS: The current study included 40 patients with pulmonary tuberculosis (culture positive, smear ±) and 42 patients with non tuberculosis pulmonary diseases (culture negative)...
June 2016: Germs
https://www.readbyqxmd.com/read/27482514/low-bone-mineral-density-and-associated-risk-factors-in-hiv-infected-patients
#18
Cristina-Emilia Chiţu-Tișu, Ecaterina-Constanţa Barbu, Mihai Lazăr, Daniela Adriana Ion, Ioana Anca Bădărău
BACKGROUND: Aging of persons with human immunodeficiency virus (HIV) resulted in high rates of osteopenia and osteoporosis. Multiple cohort studies have reported an increased prevalence of bone demineralization among HIV-infected individuals. The aim of this study was to evaluate bone mineral density (BMD) and risk factors for osteopenia/osteoporosis among HIV-positive patients attending the National Institute for Infectious Diseases "Prof.Dr. Matei Balș", Bucharest, Romania. METHODS: We performed a cross-sectional study that enrolled 60 patients with HIV...
June 2016: Germs
https://www.readbyqxmd.com/read/27482513/managing-sticky-situations-anti-biofilm-agents
#19
Oana Săndulescu
No abstract text is available yet for this article.
June 2016: Germs
https://www.readbyqxmd.com/read/27019830/antibiotic-susceptibility-patterns-of-aerobic-bacterial-strains-isolated-from-patients-with-burn-wound-infections
#20
Hamid Vaez, Fahimeh Beigi
No abstract text is available yet for this article.
March 2016: Germs
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