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Advances in Wound Care

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https://www.readbyqxmd.com/read/27867755/nutritional-aspects-of-gastrointestinal-wound-healing
#1
REVIEW
Kaushik Mukherjee, Sandra L Kavalukas, Adrian Barbul
Significance: Although the wound healing cascade is similar in many tissues, in the gastrointestinal tract mucosal healing is critical for processes such as inflammatory bowel disease and ulcers and healing of the mucosa, submucosa, and serosal layers is needed for surgical anastomoses and for enterocutaneous fistula. Failure of wound healing can result in complications including infection, prolonged hospitalization, critical illness, organ failure, readmission, new or worsening enterocutaneous fistula, and even death...
November 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27867754/a-small-chimeric-fibronectin-fragment-accelerates-dermal-wound-repair-in-diabetic-mice
#2
Denise C Hocking, James R Brennan, Carol H Raeman
Objective: During wound repair, soluble fibronectin is converted into biologically active, insoluble fibrils via a cell-mediated process. This fibrillar, extracellular matrix (ECM) form of fibronectin stimulates cell processes critical to tissue repair. Nonhealing wounds show reduced levels of ECM fibronectin fibrils. The objective of this study was to produce a small, recombinant wound supplement with the biological activity of insoluble fibronectin fibrils. Approach: A chimeric fibronectin fragment was produced by inserting the integrin-binding Arg-Gly-Asp (RGD) loop from the tenth type III repeat of fibronectin (FNIII10) into the analogous site within the heparin-binding, bioactive fragment of the first type III repeat (FNIII1H)...
November 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27867753/diabetic-wounds-exhibit-decreased-ym1-and-arginase-expression-with-increased-expression-of-il-17-and-il-20
#3
Phillip J Finley, Cory E DeClue, Scott A Sell, Joseph M DeBartolo, Laurie P Shornick
Objective: Impaired wound healing in diabetic (DB) patients is a significant health problem; however, the roles that cytokines and innate immune cells contribute to this impaired healing are not completely understood. Approach: A mouse model was used to compare the innate immune response during DB and normal wound healing. Two 5-mm full-thickness wounds were created on the dorsal skin of BKS.Cg-m+/+Leprdb/J (DB) and C57BL/6 (wild-type) mice. Innate immune cell markers and cytokine mRNA levels were measured in wound biopsies during the first week of healing...
November 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27867752/comparing-the-effectiveness-of-polymer-debriding-devices-using-a-porcine-wound-biofilm-model
#4
Holly N Wilkinson, Andrew J McBain, Christian Stephenson, Matthew J Hardman
Objective: Debridement to remove necrotic and/or infected tissue and promote active healing remains a cornerstone of contemporary chronic wound management. While there has been a recent shift toward less invasive polymer-based debriding devices, their efficacy requires rigorous evaluation. Approach: This study was designed to directly compare monofilament debriding devices to traditional gauze using a wounded porcine skin biofilm model with standardized application parameters. Biofilm removal was determined using a surface viability assay, bacterial counts, histological assessment, and scanning electron microscopy (SEM)...
November 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27785380/the-management-of-combat-wounds-the-british-military-experience
#5
REVIEW
Steven L A Jeffery
The concept of the military wound is not an easy entity to define as the wounds seen in conflict can be of many types: those caused by recognized or improvised weapon systems may have similarities to civilian wounds as well as the wounds soldiers sustain outside of battle. This article will focus on the current treatment approaches to combat wounds sustained by the deployed UK Armed Forces personnel.
October 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27785379/extracellular-bacterial-proteases-in-chronic-wounds-a-potential-therapeutic-target
#6
REVIEW
Louise Suleman
Significance: Bacterial biofilms are considered to be responsible for over 80% of persistent infections, including chronic lung infections, osteomyelitis, periodontitis, endocarditis, and chronic wounds. Over 60% of chronic wounds are colonized with bacteria that reside within a biofilm. The exaggerated proteolytic environment of chronic wounds, more specifically elevated matrix metalloproteinases, is thought to be one of the possible reasons as to why chronic wounds fail to heal. However, the role of bacterial proteases within chronic wounds is not fully understood...
October 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27785378/targeting-microtubules-for-wound-repair
#7
REVIEW
Rabab A Charafeddine, Joshua D Nosanchuk, David J Sharp
Significance: Fast and seamless healing is essential for both deep and chronic wounds to restore the skin and protect the body from harmful pathogens. Thus, finding new targets that can both expedite and enhance the repair process without altering the upstream signaling milieu and causing serious side effects can improve the way we treat wounds. Since cell migration is key during the different stages of wound healing, it presents an ideal process and intracellular structural machineries to target. Recent Advances and Critical Issues: The microtubule (MT) cytoskeleton is rising as an important structural and functional regulator of wound healing...
October 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27785377/peroxy-pyruvic-acid-containing-topical-anti-infective-a-potential-candidate-for-a-wound-instillation-solution
#8
Edwin D Neas, Julie A Dunn, Evelyn Dimaano Silva, A Morgan Chambers, Gary J Luckasen, Adam Jaskowiak
Objective: Evaluate the therapeutic properties of a peroxy pyruvic acid (PPA)-containing topical anti-infective in a human ex-vivo model that replicates the natural conditions of a human chronic wound. Approach: Wound material was extracted from patients with nonhealing diabetic ulcers, venous stasis ulcers, and arterial wounds. Microbial species were identified, and wound colonization was quantified. Extracted samples were then exposed to a PPA-containing topical anti-infective as an instillation solution with negative pressure wound therapy NPWT at concentrations of 1,000, 1,500, or 2,500 ppm for a period of 1, 5, or 10 min to determine the effect of exposure on isolated pathogens, including effect on proteins...
October 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27785376/platelet-hyperactivity-in-tnfsf14-light-knockout-mouse-model-of-impaired-healing
#9
Sandeep Dhall, Zubair A Karim, Fadi T Khasawneh, Manuela Martins-Green
Objective: Impaired and chronic wounds occur due to defects in one or more of the overlapping stages of healing. However, problems related to the vascular system are critical for nonhealing, and chronic wounds in humans often show the presence of fibrin cuffs/clots. We hypothesized that these clots are due to alterations in platelet function; hence, we have investigated whether alterations in platelet function are present during impaired healing. Approach: Platelets were subjected to different agonists to determine the rate of aggregation and evaluate the molecules involved in adhesion and aggregation that could lead to faster thrombosis and potentially contribute to impaired wound healing...
October 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27679752/plastic-surgery-challenges-in-war-wounded-ii-regenerative-medicine
#10
Ian L Valerio, Jennifer M Sabino, Christopher L Dearth
Background: A large volume of service members have sustained complex injuries during Operations Iraqi Freedom (OIF) and Enduring Freedom (OEF). These injuries are complicated by contamination with particulate and foreign materials, have high rates of bacterial and/or fungal infections, are often composite-type defects with massive soft tissue wounds, and usually have multisystem involvement. While traditional treatment modalities remain a mainstay for optimal wound care, traditional reconstruction approaches alone may be inadequate to fully address the scope and magnitude of such massive complex wounds...
September 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27679751/plastic-surgery-challenges-in-war-wounded-i-flap-based-extremity-reconstruction
#11
Jennifer M Sabino, Julia Slater, Ian L Valerio
Scope and Significance: Reconstruction of traumatic injuries requiring tissue transfer begins with aggressive resuscitation and stabilization. Systematic advances in acute casualty care at the point of injury have improved survival and allowed for increasingly complex treatment before definitive reconstruction at tertiary medical facilities outside the combat zone. As a result, the complexity of the limb salvage algorithm has increased over 14 years of combat activities in Iraq and Afghanistan. Problem: Severe poly-extremity trauma in combat casualties has led to a large number of extremity salvage cases...
September 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27679750/personalized-medicine-in-ocular-fibrosis-myth-or-future-biomarkers
#12
Cynthia Yu-Wai-Man, Peng Tee Khaw
Significance: Fibrosis-related events play a part in the pathogenesis or failure of treatment of virtually all the blinding diseases around the world, and also account for over 40% of all deaths. It is well established that the eye and other tissues of some group of patients, for example Afro-Caribbean people, scar worse than others. However, there is a current lack of reliable biomarkers to stratify the risk of scarring and postsurgical fibrosis in the eye. Recent Advances: Recent studies using genomics, proteomics, metabolomics, clinical phenotyping, and high-resolution in vivo imaging techniques have revealed potential novel biomarkers to identify and stratify patients at risk of scarring in different fibrotic eye diseases...
September 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27679749/negative-pressure-wound-therapy-in-the-management-of-combat-wounds-a-critical-review
#13
Sanjay Maurya, Prem Singh Bhandari
Significance: Wounds sustained in a combat trauma often result in a composite tissue loss. Combat injuries, due to high energy transfer to tissues, lead to trauma at multiple anatomical sites. An early wound cover is associated with lower rate of infections and a faster wound healing. The concept of negative pressure wound therapy (NPWT) in the management of combat-related wounds has evolved from the civilian trauma and the wounds from nontraumatic etiologies. Recent Advances: Encouraged by the results of NPWT in noncombat-related wounds, the military surgeons during Operation Iraqi Freedom and Operation Enduring Freedom used this novel method in a large percentage of combat wounds, with gratifying results...
September 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27602255/imaging-techniques-for-clinical-burn-assessment-with-a-focus-on-multispectral-imaging
#14
Jeffrey E Thatcher, John J Squiers, Stephen C Kanick, Darlene R King, Yang Lu, Yulin Wang, Rachit Mohan, Eric W Sellke, J Michael DiMaio
Significance: Burn assessments, including extent and severity, are some of the most critical diagnoses in burn care, and many recently developed imaging techniques may have the potential to improve the accuracy of these evaluations. Recent Advances: Optical devices, telemedicine, and high-frequency ultrasound are among the highlights in recent burn imaging advancements. We present another promising technology, multispectral imaging (MSI), which also has the potential to impact current medical practice in burn care, among a variety of other specialties...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27602254/critical-review-of-noninvasive-optical-technologies-for-wound-imaging
#15
Maanasa Jayachandran, Suset Rodriguez, Elizabeth Solis, Jiali Lei, Anuradha Godavarty
Significance: Noninvasive imaging approaches can provide greater information about a wound than visual inspection during the wound healing and treatment process. This review article focuses on various optical imaging techniques developed to image different wound types (more specifically ulcers). Recent Advances: The noninvasive optical imaging approaches in this review include hyperspectral imaging, multispectral imaging, near-infrared spectroscopy (NIRS), diffuse reflectance spectroscopy, optical coherence tomography, laser Doppler imaging, laser speckle imaging, spatial frequency domain imaging, and fluorescence imaging...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27602253/thz-imaging-of-skin-burn-seeing-the-unseen-an-overview
#16
Moumita Dutta, Amar S Bhalla, Ruyan Guo
Significance: This review article puts together all the studies performed so far in realizing terahertz (THz) spectra as a probing mechanism for burn evaluation, summarizing their experimental conditions, observations, outcomes, merits, and demerits, along with a comparative discussion of other currently used technologies to present the state of art in a condensed manner. The key features of this noncontact investigation technique like its precise burn depth analysis and the approaches it follows to convert the probed data into a quantitative measure have also been discussed in this article...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27602252/in-vivo-monitoring-of-microcirculation-in-burn-healing-process-with-optical-microangiography
#17
Wan Qin, Yuandong Li, Jingang Wang, Xiaoli Qi, Ruikang K Wang
Objective: Optical microangiography (OMAG)-based optical coherence tomography is a noninvasive technique capable of imaging functional microvasculature innervating scanned tissue volume. In this study, we utilize OMAG to investigate dynamic changes of microcirculation during the healing process of a burn. Approach: A soft-contact superficial burn injury was induced on a mouse ear with 1 μL 70°C hot water. Microangiograms were generated by using OMAG before and after the burn. Results: Vessel recruitment and remodeling were observed in the healing process...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27602251/can-imaging-put-the-advanced-back-in-advanced-wound-care
#18
Ralph S DaCosta, Kathryn Ottolino-Perry, Jaideep Banerjee
An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless "innovative" treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been innovation in wound diagnostics...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27366592/regenerative-medicine-charting-a-new-course-in-wound-healing
#19
Geoffrey C Gurtner, Mary Ann Chapman
Significance: Chronic wounds are a prevalent and costly problem in the United States. Improved treatments are needed to heal these wounds and prevent serious complications such as infection and amputation. Recent Advances: In wound healing, as in other areas of medicine, technologies that have the potential to regenerate as opposed to repair tissue are gaining ground. These include customizable nanofiber matrices incorporating novel materials; a variety of autologous and allogeneic cell types at various stages of differentiation (e...
July 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27366591/a-novel-nude-mouse-model-of-hypertrophic-scarring-using-scratched-full-thickness-human-skin-grafts
#20
Saad M Alrobaiea, Jie Ding, Zengshuan Ma, Edward E Tredget
Objective: Hypertrophic scar (HTS) is a dermal form of fibroproliferative disorder that develops following deep skin injury. HTS can cause deformities, functional disabilities, and aesthetic disfigurements. The pathophysiology of HTS is not understood due to, in part, the lack of an ideal animal model. We hypothesize that human skin with deep dermal wounds grafted onto athymic nude mice will develop a scar similar to HTS. Our aim is to develop a representative animal model of human HTS. Approach: Thirty-six nude mice were grafted with full thickness human skin with deep dermal scratch wound before or 2 weeks after grafting or without scratch...
July 1, 2016: Advances in Wound Care
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