journal
MENU ▼
Read by QxMD icon Read
search

Advances in Wound Care

journal
https://www.readbyqxmd.com/read/29755852/high-frequency-generator-in-wound-healing-of-marjolin-s-ulcer-after-carcinoma-resection
#1
Pascale Mutti Tacani, Rogério Eduardo Tacani, Aline Fernanda Perez Machado, Débora Montezello, João Carlos Guedes Sampaio Góes, Angela Gonçalves Marx, Richard Eloin Liebano
Marjolin's ulcers (MU) are skin malignancies that form over burn injuries. These very aggressive ulcers can result in functional and wound healing impairment, and require a well thought out treatment plan. Physiotherapy offers resources to help promote recovery of these patients, as described in this case report, in which the patient with a history of burn in the lower limbs evolved to malignancy 32 years later. This patient underwent tumor resection of the left foot, with recurrence and lymphadenectomy . Physical therapy included the application of high-frequency generator (HFG) for wound healing and exercises for functional recovery...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29755851/a-comparison-of-three-methods-for-the-analysis-of-skin-flap-viability-reliability-and-validity
#2
Carla Roberta Tim, Cintia Cristina Santi Martignago, Viviane Ribeiro da Silva, Estefany Camila Bonfim Dos Santos, Fabiana Nascimento Vieira, Nivaldo Antonio Parizotto, Richard Eloin Liebano
Objective: Technological advances have provided new alternatives to the analysis of skin flap viability in animal models; however, the interrater validity and reliability of these techniques have yet to be analyzed. The present study aimed to evaluate the interrater validity and reliability of three different methods: weight of paper template (WPT), paper template area (PTA), and photographic analysis. Approach: Sixteen male Wistar rats had their cranially based dorsal skin flap elevated. On the seventh postoperative day, the viable tissue area and the necrotic area of the skin flap were recorded using the paper template method and photo image...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29755850/three-dimensional-printing-and-cell-therapy-for-wound-repair
#3
REVIEW
Sylvia van Kogelenberg, Zhilian Yue, Jeremy N Dinoro, Christopher S Baker, Gordon G Wallace
Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Recent Advances: Various bioprinting techniques have been employed in wound repair-based skin tissue engineering, from laser-induced forward transfer to extrusion-based methods, and with the investigation of the benefits and shortcomings of each, with emphasis on biological compatibility and cell proliferation, migration, and vitality...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29696098/collagen-fibers-in-the-healing-process-of-rat-achilles-tendon-rupture-using-different-times-of-ultrasound-therapy
#4
Thiago Saikali Farcic, Cristiano Schiavinato Baldan, Aline Fernanda Perez Machado, Leonardo Affonso Massabki Caffaro, Igor Fagioli Bordello Masson, Raquel Aparecida Casarotto
Objective: The aim of this study was to evaluate the organization of collagen fibers in the healing process of rat Achilles tendon rupture using different times of ultrasound therapy (TUS). Approach: Forty Wistar rats were selected. Among these, 32 were submitted to total tenotomy of the calcaneous tendon and divided into 5 groups: control group (CG, n  = 8), without tenotomy or any treatment; tenotomy group ( n  = 8), with tenotomy and without treatment; TUS groups-TUS3 ( n  = 8), TUS4 ( n  = 8), and TUS5 ( n  = 8)-submitted to tenotomy and treated with TUS for 3, 4, and 5 min per effective radiating area (ERA), respectively...
April 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29675338/assessing-the-healing-of-venous-leg-ulcers-using-a-noncontact-near-infrared-optical-imaging-approach
#5
Jiali Lei, Suset Rodriguez, Maanasa Jayachandran, Elizabeth Solis, Katrina Epnere, Francisco Perez-Clavijo, Stephen Wigley, Anuradha Godavarty
Objective: Venous leg ulcers (VLUs) are one of the most common complications in lower extremity wounds. To date, clinicians employ visual inspection of the wound site during its healing process by monitoring surface granulation and reduction in wound size across weeks of treatment. In this study, a handheld near-infrared optical scanner (NIROS) has been developed at the Optical Imaging Laboratory to differentiate healing from nonhealing VLUs based on differences in blood flow to the wound and its surroundings...
April 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29675337/highly-diluted-acetylcholine-promotes-wound-repair-in-an-in-vivo-model
#6
Francesca Uberti, Vera Morsanuto, Sabrina Ghirlanda, Sara Ruga, Nausicaa Clemente, Cristina Boieri, Renzo Boldorini, Claudio Molinari
Objective: Wound healing is a dynamic, interactive, and complex process that involves a series of events, including inflammation, migration, proliferation, granulation tissue formation, and matrix remodeling. Despite the high frequency of serious slow-healing wounds, there is still no adequate therapy. The aim of this study is to evaluate a new highly diluted acetylcholine (Ach) formulation obtained through a sequential kinetic activation (SKA) method applied to a wound healing in vivo model to verify the hypothesis that a low dose of Ach could be a more physiological stimulus for healing, by stimulating muscarinic and nicotinic receptors and their related intracellular pathways...
April 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29675336/bacterial-aggregates-establish-at-the-edges-of-acute-epidermal-wounds
#7
Lene Bay, Kasper N Kragh, Steffen R Eickhardt, Steen S Poulsen, Lise Mette R Gjerdrum, Khaled Ghathian, Henrik Calum, Magnus S Ågren, Thomas Bjarnsholt
Objective: The bacterial composition and distribution were evaluated in acute standardized epidermal wounds and uninjured skin by a molecular in situ technology benchmarked to conventional culturing. This was done to reveal whether bacterial biofilm is present in acute wounds. Approach: On the buttock of 26 healthy volunteers, 28 suction blisters were made and de-roofed. Four wounds were biopsied immediately after wounding, whereas the remaining 24 wounds were treated daily with sterile deionized water and covered with a moisture-retaining dressing...
April 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29644146/xanthine-oxidoreductase-a-novel-therapeutic-target-for-the-treatment-of-chronic-wounds
#8
REVIEW
Melissa L Fernandez, Dario Stupar, Tristan Croll, David Leavesley, Zee Upton
Significance: Chronic wounds are a major burden to patients and to healthcare systems worldwide. These wounds are difficult to heal and treatment is often lengthy and expensive. This has led to research efforts focussed on the wound environment attempting to understand the underlying pathological mechanisms of impaired wound healing. While some of this research has translated to advancements in wound therapies and implementation of new treatment options, chronic wounds remain a significant challenge to treat...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29644145/publicly-reported-wound-healing-rates-the-fantasy-and-the-reality
#9
REVIEW
Caroline E Fife, Kristen A Eckert, Marissa J Carter
Significance: We compare real-world data from the U.S. Wound Registry (USWR) with randomized controlled trials and publicly reported wound outcomes and develop criteria for honest reporting of wound outcomes, a requirement of the new Quality Payment Program (QPP). Recent Advances: Because no method has existed by which wounds could be stratified according to their likelihood of healing among real-world patients, practitioners have reported fantastically high healing rates. The USWR has developed several risk-stratified wound healing quality measures for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) as part of its Qualified Clinical Data Registry (QCDR)...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29644144/comparative-effectiveness-of-a-bioengineered-living-cellular-construct-and-cryopreserved-cadaveric-skin-allograft-for-the-treatment-of-venous-leg-ulcers-in-a-real-world-setting
#10
Terry Treadwell, Michael L Sabolinski, Michelle Skornicki, Nathan B Parsons
Objective: A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking. Approach: This analysis was designed to compare the effectiveness of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799 VLUs) receiving treatment at 177 wound care centers...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29392094/review-of-the-current-management-of-pressure-ulcers
#11
REVIEW
Tatiana V Boyko, Michael T Longaker, George P Yang
Significance: The incidence of pressure ulcers is increasing due to our aging population and the increase in the elderly living with disability. Learning how to manage pressure ulcers appropriately is increasingly important for all professionals in wound care. Recent Advances: Many new dressings and treatment modalities have been developed over the recent years and the goal of this review is to highlight their benefits and drawbacks to help providers choose their tools appropriately. Critical Issues: Despite an increased number of therapies available on the market, none has demonstrated any clear benefit over the others and pressure ulcer treatment remains frustrating and time-consuming...
February 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29392093/mechanical-forces-in-cutaneous-wound-healing-emerging-therapies-to-minimize-scar-formation
#12
REVIEW
Leandra A Barnes, Clement D Marshall, Tripp Leavitt, Michael S Hu, Alessandra L Moore, Jennifer G Gonzalez, Michael T Longaker, Geoffrey C Gurtner
Significance: Excessive scarring is major clinical and financial burden in the United States. Improved therapies are necessary to reduce scarring, especially in patients affected by hypertrophic and keloid scars. Recent Advances: Advances in our understanding of mechanical forces in the wound environment enable us to target mechanical forces to minimize scar formation. Fetal wounds experience much lower resting stress when compared with adult wounds, and they heal without scars. Therapies that modulate mechanical forces in the wound environment are able to reduce scar size...
February 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29392092/cutaneous-scarring-basic-science-current-treatments-and-future-directions
#13
REVIEW
Clement D Marshall, Michael S Hu, Tripp Leavitt, Leandra A Barnes, H Peter Lorenz, Michael T Longaker
Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Recent Advances: Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Wound healing and scar formation are well described on the cellular and molecular levels, but truly effective molecular or cell-based antiscarring treatments still do not exist...
February 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29344431/noncoding-rnas-in-wound-healing-a-new-and-vast-frontier
#14
REVIEW
Anna Luan, Michael S Hu, Tripp Leavitt, Elizabeth A Brett, Kevin C Wang, Michael T Longaker, Derrick C Wan
Significance: Wound healing requires a highly orchestrated coordination of processes that are not yet fully understood. Therefore, available clinical therapies are thus far limited in their efficacy in preventing and treating both chronic wounds and scars. Current gene-based therapeutics is largely based on our understanding of the protein-coding genome and proteins involved in known wound healing pathways. Recent Advances: Noncoding RNAs such as microRNAs and long noncoding RNAs have recently been found to be significant modulators of gene expression in diverse cellular pathways...
January 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29344430/an-improved-humanized-mouse-model-for-excisional-wound-healing-using-double-transgenic-mice
#15
Michael S Hu, Justin Cheng, Mimi R Borrelli, Tripp Leavitt, Graham G Walmsley, Elizabeth R Zielins, Wan Xing Hong, Alexander T M Cheung, Dominik Duscher, Zeshaan N Maan, Dre M Irizarry, Brad Stephan, Fereydoun Don Parsa, Derrick C Wan, Geoffrey C Gurtner, Hermann Peter Lorenz, Michael T Longaker
Objective: Splinting full-thickness cutaneous wounds in mice has allowed for a humanized model of wound healing. Delineating the epithelial edge and assessing time to closure of these healing wounds via macroscopic visualization have remained a challenge. Approach: Double transgenic mice were created by crossbreeding K14-Cre and ROSAmT/mG reporter mice. Full-thickness excisional wounds were created in K14-Cre/ROSAmT/mG mice (n = 5) and imaged using both normal and fluorescent light on the day of surgery, and every other postoperative day (POD) until wound healing was complete...
January 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29344429/pathway-analysis-of-gene-expression-of-e14-versus-e18-fetal-fibroblasts
#16
Michael S Hu, Mimi R Borrelli, Michael Januszyk, Anna Luan, Samir Malhotra, Graham G Walmsley, Wan Xing Hong, Ruth Tevlin, Geoffrey C Gurtner, Michael T Longaker, Hermann P Lorenz
Objective: Fetuses early in gestation heal skin wounds without forming scars. The biological mechanisms behind this process are largely unknown. Fibroblasts, however, are cells known to be intimately involved in wound healing and scar formation. We examined fibroblasts in different stages of development to characterize differences in gene expression that may result in the switch from regenerative wound repair to repair with scarring. Approach: Fibroblasts were isolated and cultured from the back skin of BALB/c wild-type mouse fetuses at embryonic day (E)14 and E18 (n = 10)...
January 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29279806/incisional-negative-pressure-wound-therapy-for-perineal-wounds-after-abdominoperineal-resection-for-rectal-cancer-a-pilot-study
#17
Maxime J M van der Valk, Eelco J R de Graaf, Pascal G Doornebosch, Maarten Vermaas
Objective: Abdominoperineal resection (APR) is associated with high incidence of surgical wound infections. The use of incisional negative-pressure wound therapy (iNPWT) is known to reduce wound infections for several surgical indications. The aim of this pilot study was to investigate the potential of a new portable negative-pressure therapy device on perineal wound healing in patients undergoing APR. Approach: A new single-use incisional negative-pressure therapy device was applied in 10 patients. A negative pressure of -80 mmHg was continued for 7 days postsurgery...
December 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29279805/a-low-cost-technique-for-intraoperative-imaging-of-cell-delivery-and-retention-in-a-model-of-delayed-wound-healing
#18
Anthony J Burand, Lauren Boland, Alex J Brown, James A Ankrum
Objective: Techniques to validate successful delivery of cell products are expensive, time-consuming, and require transport of the animal to imaging facilities, preventing their widespread use as documentation tools. The goal of this study was to determine if a low-cost portable microscope could provide sufficient performance to be used to document delivery of cell products and track retention over time. Approach: A Dino-Lite fluorescence microscope and an Odyssey CLx whole-animal scanner were compared on the basis of resolution, sensitivity, and linearity...
December 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29279804/a-comparison-of-the-effects-of-topical-prolavacid-solution-a-polyhexamethylene-biguanide-based-wound-cleanser-and-medihoney-ointment-in-a-rat-model-of-cutaneous-wound
#19
Shahram Paydar, Bijan Ziaeian, Amirreza Dehghanian, Mohsen Heidarpour, Roshanak Alavi Moghadam, Behnam Dalfardi, Abbas Hallaj Karladani
Objective: This experimental work examined the healing effect and probable adverse impact of topical Prolavacid® solution (a polyhexamethylene biguanide-based wound cleanser) and topical Medihoney ointment in an animal model of cutaneous wound. Approach: We randomly divided 22 adult Sprague-Dawley rats (all were male) in two groups ( n  = 11): (1) those for which Prolavacid solution was poured on the skin wound surface; and (2) those animals for which Medihoney® ointment was applied to the wounds. These two agents were applied daily throughout the study period (21 days)...
December 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29279803/wound-healing-potential-of-oil-of-hypercium-perforatum-in-excision-wounds-of-male-sprague-dawley-rats
#20
Shivananada B Nayak, Kubra Isik, Julien R Marshall
Objective: To evaluate the wound-healing activity of oil of Hypercium perforatum (St. John's wort), in excision wounds of male white rats. Approach: The current methods of wound management involve the use of antibiotic creams. The search for more natural materials for the purpose of healing of wounds has led to the discoveries of potential agents prepared from plant extracts. Hyperforin and Hypericin are important phytochemical constituents found in H. perforatum, which have been highlighted for their antimicrobial, antiviral, and anti-inflammatory properties in recent times...
December 1, 2017: Advances in Wound Care
journal
journal
48165
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"